Solar urticaria

L12_SOLURTICARIA

photosensitivity disease: Photosensitivity refers to various symptoms, diseases and conditions caused or aggravated by exposure to sunlight.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 L56.3
  • Cause of death: ICD-10 L56.3

2 out of 7 registries used, show all original rules.

58

4. Check minimum number of events

None

58

5. Include endpoints

None

58

6. Filter based on genotype QC (FinnGen only)

50

Control definitions (FinnGen only)

Control exclude
L12_RADIATIONRELATEDSKIN

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L56
Name in latin
Urticaria solaris

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 367 234 132
Only index persons 304 203 101
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.00
Only index persons 0.01 0.01 0.00
Median age at first event (years)
Whole population 30.97 35.89 22.21
Only index persons 37.92 40.56 32.62

-FinnGen-

Key figures

All Female Male
Number of individuals 50 38 12
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 47.88 42.51 64.90

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
52
Matched controls
520
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L56.3
ICD-10 Finland
Solar urticaria
+∞
74.4
52
*
L56.4
ICD-10 Finland
Polymorphous light eruption
121.2
9.8
10
*
J45.9
ICD-10 Finland
Asthma, unspecified
5.5
7.0
17
42
L50.8
ICD-10 Finland
Other urticaria
46.2
7.0
8
*
D07AC01
ATC
betamethasone; topical
4.6
6.9
29
112
XQ802
NOMESCO Finland
Epicutan test
15.1
6.4
10
8
L30.9
ICD-10 Finland
Dermatitis, unspecified
4.4
6.1
21
69

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
34
200
3.02
3.53
8.1
11.2
0.00
0.00
e9/l
-0.00
27
162
25
146
2.37
2.35
6.3
6.4
—
—
—
0
0
5
10
5.40
2.12
1.2
1.2
—
—
—
0
0
8
28
3.19
1.96
1.0
1.1
—
—
—
0
0
35
254
2.16
1.78
6.6
7.1
0.20
0.18
e9/l
0.23
30
230
34
245
2.12
1.75
6.5
7.1
2.39
1.92
e9/l
0.62
28
227
32
228
2.05
1.67
6.3
6.4
29.09
28.69
%
0.07
32
222
33
239
2.04
1.63
6.5
7.2
0.60
0.56
e9/l
0.46
27
215
32
231
2.00
1.57
6.3
6.1
58.00
57.47
%
0.09
32
222
33
241
2.01
1.57
6.5
7.1
0.05
0.04
e9/l
0.45
27
216
6
21
3.09
1.55
1.2
1.0
—
—
—
0
0
21
138
1.88
1.30
2.5
4.1
7.39
7.40
ph
0.11
13
95
6
25
2.58
1.28
1.0
1.2
—
—
—
0
0
5
19
2.80
1.24
1.2
1.5
0.24
0.23
g/l
—
5
19
5
20
2.65
1.18
1.2
1.5
1.54
1.21
g/l
—
5
20
30
230
1.72
1.06
6.5
6.3
7.73
8.26
%
0.56
30
220
9
147
0.53
0.99
3.6
2.6
—
—
—
0
0
26
196
1.65
0.95
2.6
1.8
—
—
—
0
0
17
115
1.71
0.92
1.9
1.4
2.56
2.04
g/l
—
9
67
21
151
1.66
0.91
14.1
5.8
—
—
—
0
0
29
228
1.61
0.88
6.7
6.3
2.52
2.69
%
0.23
29
216
0
24
0.00
0.81
0.0
1.5
—
—
—
0
0
0
25
0.00
0.81
0.0
1.6
—
—
—
0
0
9
53
1.84
0.81
1.3
1.3
—
—
—
0
0
0
26
0.00
0.81
0.0
1.5
—
—
—
0
0
0
26
0.00
0.81
0.0
1.5
—
—
—
0
0
0
26
0.00
0.81
0.0
1.5
—
—
—
0
0
9
55
1.77
0.79
1.1
1.3
—
—
—
0
0
9
55
1.77
0.79
1.2
1.1
—
—
—
0
0
7
43
1.72
0.70
1.1
1.2
—
—
—
0
0
19
243
0.66
0.68
2.2
2.7
—
—
estimate
—
0
0
8
49
1.75
0.66
1.6
8.7
0.98
1.06
mmol/l
—
8
42
11
72
1.67
0.65
1.3
1.8
—
—
—
0
0
0
20
0.00
0.62
0.0
1.4
—
—
—
0
0
17
219
0.67
0.61
3.2
3.4
6.07
6.20
ph
—
7
115
45
412
1.68
0.56
25.2
17.7
330.53
332.24
g/l
0.53
45
412
6
40
1.56
0.53
1.0
1.8
—
—
—
0
0
24
198
1.39
0.49
2.5
2.0
105.15
100.18
pmol/l
0.16
13
104
17
134
1.40
0.44
4.6
3.8
1.76
10.91
mg/mmol
—
7
76
0
16
0.00
0.42
0.0
5.2
—
—
—
0
0
5
36
1.43
0.39
1.8
2.5
—
—
—
0
0
12
93
1.38
0.33
1.5
1.7
0.51
0.72
mg/l
—
7
76
7
54
1.34
0.32
1.3
1.4
—
—
—
0
0
16
133
1.29
0.29
3.3
3.1
10.73
58.86
mg/l
—
6
78
10
125
0.75
0.26
4.8
3.6
—
—
—
0
0
6
82
0.70
0.26
1.2
1.5
—
—
—
0
0
14
166
0.79
0.25
2.3
2.1
—
—
—
0
0
17
146
1.24
0.23
4.8
3.2
—
—
—
0
0
0
11
0.00
0.21
0.0
2.4
—
58.55
—
0
11
21
186
1.22
0.21
3.2
2.9
—
—
—
0
0
0
10
0.00
0.21
0.0
2.5
—
9.09
—
0
10
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.9
—
10.60
—
0
10
0
10
0.00
0.21
0.0
2.2
—
121.40
—
0
5
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
6
48
1.28
0.21
1.2
1.4
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
5
68
0.71
0.18
2.4
2.5
—
—
—
0
0
6
77
0.75
0.17
1.7
1.7
450.67
475.20
pmol/l
—
6
70
29
270
1.17
0.15
5.1
4.3
7.30
6.35
mmol/l
1.04
29
246
13
148
0.84
0.15
1.8
1.5
—
—
—
0
0
14
158
0.84
0.14
2.2
3.3
8.50
43.74
ng/l
—
7
97
15
136
1.14
0.10
2.3
2.7
—
—
estimate
—
0
0
10
113
0.86
0.09
1.4
2.2
6.74
5.17
e6/l
—
10
105
5
64
0.76
0.08
1.4
1.7
—
—
—
0
0
8
90
0.87
0.07
2.3
1.9
—
—
—
0
0
13
119
1.12
0.06
4.5
3.9
—
—
—
0
0
34
332
1.07
0.02
4.8
4.2
—
—
—
0
0
11
117
0.92
0.02
3.2
6.5
—
—
—
0
0
33
331
0.99
0.00
4.9
4.2
—
59.40
—
0
5
13
134
0.96
0.00
2.5
2.3
—
—
—
0
0
11
108
1.02
0.00
1.5
1.9
—
—
—
0
0
0
7
0.00
0.00
0.0
2.3
—
5.03
—
0
7
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
2.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
18.67
—
0
6
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
2.3
—
9.81
—
0
7
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
117.17
—
0
6
0
7
0.00
0.00
0.0
3.1
—
3.93
—
0
7
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
9
0.00
-0.00
0.0
3.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
6.76
—
0
5
5
55
0.90
-0.00
1.2
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
1.65
—
0
5
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.8
—
—
—
0
0
6
58
1.04
-0.00
3.3
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
109.90
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.0
—
1.20
—
0
5
0
5
0.00
-0.00
0.0
1.6
—
56.20
—
0
5
0
5
0.00
-0.00
0.0
2.2
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint L12_SOLURTICARIA and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have L12_SOLURTICARIA.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: L12_SOLURTICARIA – Solar urticaria

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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