Generalized pustular psoriasis

L12_PSORI_PUSTGEN

impetigo herpetiformis: An impetigo that is characterized as a form of severe pustular psoriasis occurring in pregnancy.

Suggest a new description

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — L40.1 Hospital discharge: ICD-9 — 6961B Hospital discharge: ICD-8 — 69610 Cause of death: ICD-10 — L40.1 Cause of death: ICD-9 — 6961B Cause of death: ICD-8 — 69610 2 out of 7 registries used, show all original rules.	149
4. Check minimum number of events None	149
5. Include endpoints None	149
6. Filter based on genotype QC (FinnGen only)	130

Control definitions (FinnGen only)

Control exclude: L12_PAPULOSQUAMOUS

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: L40
Name in latin: Psoriasis pustulosa generalisata

NAME	L12_PSORI_PUSTGEN
CONTROL_EXCLUDE	L12_PAPULOSQUAMOUS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	L401
HD_ICD_9	6961B
HD_ICD_8	69610
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	L401
COD_ICD_9	6961B
COD_ICD_8	69610
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Generalized pustular psoriasis based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	983	481	487
Only index persons	740	384	356
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	54.30	56.74	51.88
Only index persons	52.55	54.23	50.72

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	130	72	58
Unadjusted period prevalence (%)	0.03	0.03	0.03
Median age at first event (years)	52.37	50.72	54.42

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
136: Matched controls
1360

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

L40.1

ICD-10 Finland

Generalized pustular psoriasis

+∞

148.5

114

D05AX52

ATC

calcipotriol, combinations; topical

82.1

115.1

L40.0

ICD-10 Finland

Psoriasis vulgaris

439.8

85.0

D07XC01

ATC

betamethasone; topical

23.3

78.6

D05AX02

ATC

calcipotriol; topical

374.5

66.7

L04AX03

ATC

methotrexate; systemic

19.3

64.4

D05BB02

ATC

acitretin; oral

272.8

64.2

D07AD01

ATC

clobetasol; topical

13.3

52.7

109

L40.5

ICD-10 Finland

Arthropathic psoriasis

+∞

45.4

D07AC01

ATC

betamethasone; topical

15.2

44.7

113

333

E000003, ,

ATC

21.9

44.3

E000001, ,

ATC

10.3

42.8

145

M07.3*L40.5

ICD-10 Finland

Other psoriatic arthropathies

+∞

41.9

E0000UV, ,

ATC

14.4

39.1

116

390

TQX10

NOMESCO Finland

Biopsy of skin and subcutaneous tissue

10.9

36.6

319

Kela drug reimbursment

Adalimumab, brodalumab, certolizumab pegol, etanercept, guselkumab, infliximab, ixekizumab, risankizumab, sekukinumab and ustekinumab (skin psoriasis)

+∞

36.1

D05AX03

ATC

calcitriol; topical

435.1

34.5

L40.9

ICD-10 Finland

Psoriasis, unspecified

224.3

34.5

202

Kela drug reimbursment

Connective tissue diseases, rheumatoid arthritis and comparable disease

9.3

32.6

NK4XE

NOMESCO Finland

Joint ultrasound examination not elsewhere classified

11.2

26.1

A07EC01

ATC

sulfasalazine; oral, rectal

9.1

25.1

D07AB02

ATC

hydrocortisone butyrate; topical

5.9

23.9

254

134

Kela drug reimbursment

General erythroderma

274.3

23.4

L40.8

ICD-10 Finland

Other psoriasis

260.1

22.3

D07AC13

ATC

mometasone; topical

5.5

22.2

254

L04AB04

ATC

adalimumab; parenteral

36.9

21.5

L01BA01

ATC

methotrexate; systemic

22.2

20.7

L40.3

ICD-10 Finland

Pustulosis palmaris et plantaris

86.5

20.4

281

Kela drug reimbursment

Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab

23.7

19.1

313

Kela drug reimbursment

Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)

22.1

18.7

TNX10

NOMESCO Finland

Arthrocentesis, unspecified region, unspecified region

8.2

18.2

D07AB08

ATC

desonide; topical

6.0

17.9

L04AD01

ATC

ciclosporin; systemic

30.7

16.2

E000002, ,

ATC

5.8

15.7

TQW80

NOMESCO Finland

Local dermatologic skincare

21.6

15.3

L04AA01

ATC

[U] ciclosporin

64.2

15.2

M07.3

ICD-10 Finland

Other psoriatic arthropathies

+∞

13.8

L27.0

ICD-10 Finland

Generalized skin eruption due to drugs and medicaments

154.8

13.7

L04AC10

ATC

secukinumab; parenteral

154.8

13.7

L30.9

ICD-10 Finland

Dermatitis, unspecified

4.2

13.3

152

H02AB06

ATC

prednisolone; systemic

4.0

13.2

479

6961A

ICD-9 Finland

Psoriasis and similar disorders, Other psoriasis[PSORIASIS VULGARIS]

+∞

12.7

L04AB01

ATC

etanercept; parenteral

24.0

12.4

M07.0*L40.5

ICD-10 Finland

Distal interphalangeal psoriatic arthropathy

+∞

11.6

L04AC05

ATC

ustekinumab; parenteral

+∞

11.6

6961B

ICD-9 Finland

Psoriasis and similar disorders, Other psoriasis[PSORIASIS PUSTULARIS]

+∞

11.6

L40

ICD-10 Finland

Psoriasis

38.7

11.5

69610

ICD-8 Finland

Psoriasis and similar disorders, Psoriasis pustulosa

+∞

10.5

D02AE01

ATC

carbamide; topical

5.5

9.9

ND2AA

NOMESCO Finland

Hand and fingers X-ray examination

4.5

9.8

L04AC13

ATC

ixekizumab; parenteral

107.2

9.5

D07BA04

ATC

hydrocortisone and antiseptics; topical

4.8

9.3

D07BB04

ATC

hydrocortisone butyrate and antiseptics; topical

4.0

9.3

WXQ27

NOMESCO Finland

UVB narrow spectrum light therapy

39.5

9.2

NH3AA

NOMESCO Finland

Foot and toes X-ray examination

4.6

9.0

E000006, ,

ATC

5.5

8.6

H02AB07

ATC

prednisone; oral

3.8

8.6

L04AA13

ATC

[U] leflunomide

11.9

8.5

L04AA11

ATC

[U] etanercept

+∞

8.4

6960A

ICD-9 Finland

Psoriasis and similar disorders, Psoriatic arthropathy

+∞

8.4

69619

ICD-8 Finland

Psoriasis and similar disorders, Psoriasis alia sive NUD (vulgaris)

+∞

8.4

GD1AA

NOMESCO Finland

Thorax X-ray examination

2.8

7.8

497

S91

ICPC

Psoriasis

47.8

7.8

D02AX

ATC

Other emollients and protectives

9.8

7.8

L04AC21

ATC

bimekizumab; systemic

+∞

7.4

D05AA

ATC

Tars

+∞

7.4

D01AC20

ATC

imidazoles/triazoles in combination with corticosteroids; topical

2.9

7.2

193

E000007, ,

ATC

6.3

7.1

D07AA02

ATC

hydrocortisone; topical

3.2

6.7

121

EB1HA

NOMESCO Finland

Panorama tomography of teeth and jaws or similar X-ray examination

2.5

6.3

375

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3037522) Nuclear Ab [Titer] in Serum

153

4.44

14.66

1.4

1.3

465.45

607.00

titre

0.21

(42870588) Differential panel, method unspecified - Blood

401

3.86

13.43

16.5

7.1

—

(3013115) Eosinophils [#/volume] in Blood

102

634

3.44

9.31

20.1

7.2

0.20

0.19

e9/l

0.52

554

(3018010) Neutrophils/Leukocytes in Blood

562

3.18

9.08

19.7

6.9

58.69

57.69

0.38

536

(40768443) Skin Pathology biopsy report

4.89

8.76

1.8

1.2

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

3.34

6.12

1.2

1.5

—

(3002179) Metamyelocytes/Leukocytes in Blood

3.08

5.56

7.1

4.8

0.25

0.50

—

(3007853) Bacteria identified in Skin by Aerobe culture

135

2.79

5.50

2.1

1.8

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

11.93

5.37

1.0

—

(3021440) Promyelocytes/Leukocytes in Blood

3.01

5.36

7.6

4.8

0.13

0.17

—

(3017181) Myelocytes/Leukocytes in Blood

106

2.80

4.73

7.6

4.7

0.50

0.81

—

(3000475) Leukocytes [#/volume] in Synovial fluid

5.21

4.63

1.8

1.7

16100.25

16485.00

e6/l

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

211

2.35

4.63

1.3

1.8

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

175

2.44

4.61

1.3

1.5

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

187

2.34

4.32

1.3

1.40

8.52

u/ml

—

(3018095) Leukocytes [#/volume] in Urine

486

2.08

4.25

7.3

4.4

82.40

63.22

e6/l

0.12

348

(3035350) Ketones [Presence] in Urine by Test strip

669

2.16

4.23

6.2

4.2

0.00

10.75

estimate

0.50

151

(3017143) Hepatitis C virus Ab [Presence] in Serum

146

2.45

4.22

1.2

1.6

—

(3025159) Blasts/Leukocytes in Blood

106

2.66

4.21

8.5

5.0

0.00

0.31

—

(3021601) Nitrite [Presence] in Urine by Test strip

662

2.13

4.14

6.2

4.1

0.00

estimate

-0.00

145

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

615

2.08

4.06

9.5

8.2

1.21

mmol/l

0.29

530

(3021788) Differential panel - Synovial fluid

5.90

4.06

1.5

1.6

—

(3000494) Fungus identified in Specimen by Culture

143

2.41

3.97

1.4

—

(3015736) pH of Urine

524

2.02

3.92

5.3

3.9

6.01

6.21

0.93

300

(3044941) Cell count panel - Synovial fluid

5.31

3.77

1.5

1.4

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

310

2.03

3.69

3.0

2.1

3.29

2.87

mg/l

0.42

266

(3009261) Glucose [Presence] in Urine by Test strip

678

2.03

3.68

6.2

4.2

0.00

estimate

-0.00

137

(3020682) Albumin/Creatinine [Ratio] in Urine

396

1.98

3.67

4.4

4.0

13.43

7.55

mg/mmol

0.45

255

(3011397) Hemoglobin [Presence] in Urine by Test strip

289

2.02

3.55

6.5

4.0

—

0.00

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.62

3.42

1.4

1.5

—

(3009508) Creatinine [Moles/volume] in Urine

412

1.87

3.15

3.6

3.3

7.72

7.70

mmol/l

0.01

351

(40760892) CBC W Ordered Manual Differential panel - Blood

268

1.95

3.09

9.4

5.4

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

212

2.02

3.09

1.5

1.3

28.09

28.13

iu/ml

—

(3019977) pH of Arterial blood

141

2.14

2.86

6.7

7.6

7.40

7.42

0.40

(40758558) Short blood count panel - Blood

387

1.81

2.83

15.1

7.3

—

(3007164) IgA [Mass/volume] in Serum or Plasma

254

1.88

2.70

1.5

1.4

3.18

2.39

g/l

0.79

142

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

2.67

2.62

1.1

—

(3023520) Reticulocytes [#/volume] in Blood

110

2.19

2.59

2.9

3.5

65.35

73.52

e9/l

0.55

(3012516) Albumin [Mass/volume] in Urine

387

1.76

2.57

3.7

3.3

81.71

47.66

mg/l

0.35

255

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

118

2.14

2.54

4.4

3.8

—

(3026008) Bacteria identified in Urine by Culture

364

1.75

2.47

3.9

3.4

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

111

941

1.98

2.46

15.4

8.7

76.84

81.06

u/l

0.61

106

886

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

2.47

2.41

1.9

2.6

—

(3032080) INR in Blood by Coagulation assay

580

1.70

2.39

15.3

12.9

1.17

1.24

inr

0.62

492

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

3.25

2.27

1.9

1.3

—

(3002582) Erythrocytes [#/volume] in Urine

436

1.67

2.23

5.8

3.7

16.97

52.13

e6/l

1.62

337

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

531

1.66

2.19

2.7

2.1

87.13

94.42

pmol/l

0.74

279

(3014051) Protein [Presence] in Urine by Test strip

357

1.69

2.17

5.4

3.4

—

0.00

—

(3030467) Casts [#/volume] in Urine by Automated count

375

1.68

2.16

5.5

3.5

0.72

0.31

e6/l

0.29

279

(3045414) Leukocytes [Presence] in Urine

127

1.98

2.10

3.1

2.0

0.00

estimate

—

(3019150) Specific gravity of Urine by Refractometry

290

1.71

2.09

5.8

4.4

1.02

kg/l

1.07

190

(3018418) pH of Serum or Plasma

379

1.65

2.06

5.4

4.1

7.40

0.17

273

(3003327) Ova and parasites identified in Stool by Light microscopy

2.94

2.04

1.6

1.5

—

(3017817) Protein [Mass] in Urine collected for unspecified duration

4.67

1.96

2.0

5.2

309.60

449.00

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

459

1.60

1.90

5.1

3.7

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

2.97

1.89

2.1

1.6

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

2.87

1.82

1.4

1.5

—

(3028369) Herpes simplex virus 1+2 DNA [Presence] in Specimen by NAA with probe detection

3.95

1.73

1.2

1.4

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

277

1.63

1.73

1.5

1.2

13.00

1.40

u/ml

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

2.68

1.69

1.5

1.1

—

(3023368) Bacteria identified in Blood by Culture

359

1.57

1.67

6.2

4.8

—

(46236952) Glomerular filtration rate [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)/1.73 sq M

1.94

1.67

4.9

3.1

49.00

62.89

ml/min/173m2

—

(3019060) Gas panel - Arterial blood

2.07

1.67

3.1

3.7

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

154

1.76

1.65

3.0

1.9

—

(3029937) Albumin [Presence] in Urine by Test strip

379

1.55

1.63

5.5

4.0

0.00

estimate

-0.00

135

(3035715) Granulocytes [#/volume] in Blood

3.09

1.60

3.7

2.1

4.32

4.24

e9/l

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

165

1.71

1.55

2.8

1.8

—

(21494890) Protein electrophoresis panel - 24 hour Urine

3.42

1.53

1.4

4.2

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

2.94

1.52

2.5

1.5

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

2.94

1.52

2.0

1.6

—

(3045424) Erythrocytes [Presence] in Urine

2.07

1.49

2.1

0.00

estimate

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

2.58

1.47

1.3

1.4

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

2.58

1.47

1.1

3.2

9.20

9.40

pmol/l

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

210

1.62

1.45

1.7

1.5

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

2.80

1.45

1.2

1.1

—

(40768804) Tissue Pathology biopsy report

493

1.47

1.40

2.4

2.0

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

310

1.51

1.36

2.2

2.3

1.79

1.59

mg/l

0.12

255

(3000991) Gas panel - Venous blood

116

1.74

1.30

8.7

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

2.36

1.29

1.4

1.1

—

(3042936) Bacteria identified in Isolate by Culture

183

1.59

1.26

2.1

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

494

1.43

1.21

2.3

2.1

1.39

1.34

mmol/l

0.31

403

(3016879) Cocaine [Presence] in Urine

2.17

1.20

1.1

1.4

—

(3000492) Spirometry study

128

1.66

1.16

1.4

1.5

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

2.55

1.16

1.4

2.8

—

(3028300) Cannabinoids [Presence] in Urine

2.06

1.14

1.1

1.4

—

(3027008) Opiates [Presence] in Urine

2.06

1.14

1.1

1.4

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

509

1.40

1.12

5.8

4.1

0.00

estimate

-0.00

116

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

206

1.52

1.11

5.0

3.5

1.43

1.61

e6/l

0.08

108

(3000764) Benzodiazepines [Presence] in Urine

2.01

1.11

1.1

1.4

—

(3027944) Amphetamines [Presence] in Urine

2.01

1.11

1.1

1.4

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

2.01

1.11

1.3

1.4

—

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

2.43

1.10

1.4

1.3

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

225

1.49

1.07

4.9

3.2

0.83

0.89

e6/l

0.05

126

(3009445) Proteinase 3 Ab [Units/volume] in Serum

2.07

1.07

1.6

1.2

—

(36660697) Celiac disease serology panel - Serum

1.70

1.05

1.3

1.1

—

(3012544) pH of Venous blood

140

1.59

1.05

3.0

4.7

7.37

7.39

0.50

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

2.05

1.01

1.1

1.3

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

219

1.47

1.01

2.8

1.9

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.98

0.0

1.6

—

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

248

1.44

0.96

5.5

3.6

902.76

103.91

ng/l

0.49

196

(3022145) Colonoscopy Study observation

135

1.56

0.96

1.7

1.3

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

1.94

0.95

1.3

1.4

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

122

1145

1.64

0.94

34.3

17.7

19.50

23.53

mg/l

1.23

112

964

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

703

1.34

0.87

2.7

3.1

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

1.98

0.85

1.7

1.1

—

(3035933) Granulocytes/Leukocytes in Blood

1.98

0.85

3.8

1.9

57.67

57.77

—

(3041096) Erythrocytes [Presence] in Urine by Automated

383

1.35

0.85

4.4

3.7

0.00

estimate

-0.00

110

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

1.78

0.84

5.0

8.9

94.00

92.67

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

1.75

0.82

2.3

1.6

—

(3048689) Calprotectin [Mass/mass] in Stool

158

1.47

0.81

3.5

2.3

262.78

137.42

ug/g

0.77

130

(40761536) Microorganisms panel - Urine sediment

1.58

0.79

4.9

3.5

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

2.22

0.77

1.2

—

(3011288) Drugs identified in Urine by Screen method Nominal

2.12

0.75

1.8

2.0

—

(3022313) Gas panel - Capillary blood

1.72

0.74

21.5

6.4

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

1.84

0.74

2.1

3.0

209.57

205.33

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.57

0.69

3.7

3.3

—

(1616796) Gas panel - Central venous blood

1.81

0.67

3.0

—

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

101

0.58

0.65

5.2

2.7

5.25

6.23

ug/l

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.64

0.62

1.3

2.0

—

(3049717) Cytology report of Urine Cyto stain

1.64

0.62

1.4

2.8

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

118

1120

1.40

0.62

5.8

5.3

6.06

5.92

mmol/l

0.50

112

1030

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.61

0.0

3.0

—

2.97

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.60

0.0

1.1

—

(3020961) Endomysium IgA Ab [Titer] in Serum

1.61

0.60

1.2

1.1

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

121

0.64

0.58

1.4

1.5

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

1.70

0.57

1.2

1.3

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

1.65

0.56

1.3

1.4

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

1.65

0.56

1.3

1.4

1.17

1.11

g/l

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

1.65

0.56

1.3

1.4

0.27

0.24

g/l

—

(3001019) Free T4 and TSH panel - Serum or Plasma

1.56

0.56

2.0

1.9

—

(3001334) Neutrophil cytoplasmic Ab [Units/volume] in Serum

1.61

0.55

1.7

1.2

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.48

0.54

1.2

2.1

—

(4010399) Spirometry for bronchospasm with prolonged evaluation after bronchodilator

110

1.41

0.51

1.2

1.5

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

114

1085

1.31

0.51

5.6

4.3

1.35

1.27

mmol/l

0.78

109

998

(40768797) Stomach Pathology biopsy report

174

1.32

0.49

1.4

1.3

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

1.52

0.48

2.4

1.7

—

(3016888) Borrelia burgdorferi IgG Ab [Units/volume] in Serum

0.60

0.47

1.0

1.4

—

15.88

—

(3030366) Cystatin C [Mass/volume] in Serum or Plasma

1.45

0.46

2.3

5.7

1.73

1.50

mg/l

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

241

1.26

0.45

1.8

1.9

416.74

454.55

pmol/l

0.29

202

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.46

0.43

3.1

1.9

—

(3020891) Body temperature

1.43

0.43

4.9

3.5

36.98

36.92

°c

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

112

1071

1.26

0.42

6.0

5.4

2.10

1.93

mu/l

0.60

107

978

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

1.53

0.42

1.2

1.9

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.41

0.0

1.1

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.41

0.0

1.1

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.41

0.0

1.1

—

(3018333) Ribosomal P Ab [Presence] in Serum

0.00

0.41

0.0

1.1

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.41

0.0

1.1

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

117

1125

1.29

0.41

6.1

5.2

1.41

1.46

mmol/l

0.71

112

1039

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.41

0.0

1.1

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.41

0.0

1.1

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

0.40

0.0

1.3

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

0.40

0.0

1.3

—

(40759850) Jo-1 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.40

0.0

1.1

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

0.40

0.0

1.3

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

0.40

0.0

1.3

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

0.39

0.0

1.6

—

16.73

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.39

0.0

1.3

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.39

0.0

1.3

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

275

1.21

0.37

6.0

2.8

—

(40761535) Cells panel - Urine sediment

1.33

0.33

5.3

3.7

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

903

1.17

0.33

5.2

4.4

14.82

14.88

pmol/l

0.07

812

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

117

1132

1.24

0.32

6.8

5.3

4.46

4.61

mmol/l

0.81

112

1053

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

129

0.76

0.29

3.8

2.8

33.80

31.81

u/l

—

103

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

113

1093

1.20

0.29

8.4

6.6

41.17

39.61

mmol/mol

1.07

107

1033

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

116

0.76

0.29

1.3

2.0

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

318

0.85

0.28

4.9

4.8

18.98

22.19

0.46

165

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

119

1158

1.22

0.27

7.1

6.0

2.65

2.70

mmol/l

0.19

114

1074

(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum

0.69

0.24

1.8

2.7

—

8.03

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

136

0.79

0.24

14.4

7.8

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

1.36

0.24

1.2

1.6

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

562

1.12

0.23

4.9

3.0

—

estimate

—

(3008898) HLA-B27 [Presence]

1.23

0.22

1.0

1.2

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

105

0.75

0.22

1.1

1.8

—

(3018301) Testosterone Free [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.4

—

211.55

—

(3012413) Glucose [Moles/volume] in Serum or Plasma --2 hours post meal

0.00

0.21

0.0

1.1

—

9.89

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.9

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.9

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.9

—

(40760543) Extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.0

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.9

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.00

0.21

0.0

1.0

—

(40768441) Liver Pathology biopsy report

0.00

0.21

0.0

1.2

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

0.21

0.0

1.2

—

13.78

—

(3005136) Cladosporium herbarum IgE Ab [Units/volume] in Serum

0.00

0.21

0.0

1.1

—

1.22

—

(3014133) Dog dander IgE Ab [Units/volume] in Serum

0.00

0.21

0.0

1.1

—

1.77

—

(3023430) Cat dander IgE Ab [Units/volume] in Serum

0.00

0.20

0.0

1.1

—

4.14

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.20

0.0

1.2

—

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

118

1.21

0.20

3.2

2.7

0.23

0.21

g/l

0.19

111

(21494755) Public health laboratory ask at order entry panel

110

1.20

0.18

1.2

1.4

—

(3025941) Bacteria identified in Stool by Culture

1.14

0.17

1.3

1.2

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

0.74

0.17

1.6

1.3

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.19

0.13

1.3

1.5

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

107

0.83

0.13

1.9

1.7

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

241

0.90

0.13

2.7

3.2

0.65

0.82

ug/l

0.57

156

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

403

0.92

0.12

6.1

5.7

1.88

2.26

ug/l

0.29

353

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

1.17

0.10

2.2

1.7

—

(3016407) Fibrinogen [Mass/volume] in Platelet poor plasma by Coagulation assay

1.14

0.10

3.6

5.4

3.72

3.60

g/l

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

1.12

0.10

1.4

2.6

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

500

0.94

0.09

5.9

4.3

27.46

38.49

ng/l

0.59

366

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

165

0.90

0.09

1.6

1.4

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.10

0.09

1.0

1.3

—

(3003785) Carcinoembryonic Ag [Mass/volume] in Serum or Plasma

146

1.11

0.08

8.2

4.6

3.46

39.08

ug/l

0.63

117

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

1.09

0.07

1.3

3.6

4.50

4.56

pmol/l

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

1.07

0.07

2.9

3.0

0.60

0.59

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.04

0.07

2.9

3.0

1.25

—

(3024731) MCV [Entitic mean volume] in Red Blood Cells

125

1238

1.12

0.07

50.1

26.2

91.92

91.21

1.01

125

1229

(3002256) Pathology report gross observation

158

1.09

0.06

1.4

1.3

—

(3022621) pH of Urine by Test strip

109

1.11

0.06

4.5

2.4

6.07

—

(3009542) Hematocrit [Volume Fraction] of Blood by calculation

125

1239

1.11

0.06

51.1

26.5

40.15

40.22

0.06

125

1230

(3035941) MCH [Entitic mass]

125

1239

1.11

0.06

50.1

26.1

30.26

30.34

0.20

125

1230

(3000963) Hemoglobin [Mass/volume] in Blood

125

1239

1.11

0.06

50.8

26.4

132.26

134.65

g/l

0.93

125

1230

(4035726) Immunohistochemistry procedure

110

1.10

0.05

1.8

1.3

—

(3044640) Blood type and Crossmatch panel - Blood

390

0.96

0.03

4.7

2.7

—

(3020564) Creatinine [Moles/volume] in Serum or Plasma

122

1214

1.05

0.00

42.8

22.2

79.45

78.12

umol/l

0.12

122

1204

(3003694) ABO and Rh group [Type] in Blood

326

0.98

0.00

1.3

1.4

—

(1761868) Lipid panel - Serum or Plasma

464

1.02

0.00

3.6

3.4

—

(3013512) EKG study

432

0.99

0.00

4.5

4.0

—

(40761511) CBC panel - Blood by Automated count

119

1188

1.01

0.00

26.7

15.2

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

814

0.99

0.00

3.5

3.3

58.95

46.21

u/l

0.68

770

(3021706) Oxygen [Partial pressure] in Arterial cord blood

0.00

0.0

1.0

—

3.43

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.0

3.6

—

0.88

—

(3019897) Erythrocyte [DistWidth] in Red Blood Cells by Automated count

0.00

0.0

3.3

—

13.28

—

(37208534) Antinuclear antibody arbitrary concentration in serum

0.00

0.0

1.0

—

(42529528) Centromere protein B Ab [Units/volume] in Serum by Line blot

0.00

0.0

1.0

—

(42870308) Desmosome IgG Ab [Titer] in Serum by Immunofluorescence

0.00

0.0

1.8

—

(3028286) Albumin [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

0.0

2.3

—

44.18

—

(3023709) Somatotropin [Mass/volume] in Serum or Plasma

0.00

0.0

3.5

—

1.63

—

(3016436) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

4.6

—

199.25

—

(40771527) Human papilloma virus E6+E7 mRNA [Presence] in Cervix by NAA with probe detection

0.00

0.0

1.5

—

(40757349) CD3+CD4+ (T4 helper) cells/CD3+CD8+ (T8 suppressor cells) cells [# Ratio] in Blood

0.00

0.0

1.5

—

1.53

—

(3026470) Cobalt [Mass/volume] in Blood

0.00

0.0

2.4

—

3.75

—

(3028433) Virus identified in Specimen by Culture

0.00

0.0

1.5

—

(3003932) Carbon dioxide [Partial pressure] in Arterial cord blood

0.00

0.0

1.0

—

6.88

—

(3029715) Chromosome analysis.interphase [Interpretation] in Bone marrow by FISH Narrative

0.00

0.0

1.8

—

(3006598) pH of Arterial cord blood

0.00

0.0

1.0

—

(3020911) Cortisol [Moles/time] in 24 hour Urine

0.00

-0.00

0.0

1.0

—

48.40

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

-0.00

0.0

2.0

—

(3013566) Clostridioides difficile [Presence] in Stool by Organism specific culture

0.00

-0.00

0.0

1.6

—

(3013637) Mi-2 Ab [Presence] in Serum

0.00

-0.00

0.0

1.0

—

(3005791) Eosinophil cationic protein (ECP) [Mass/volume] in Serum

0.00

-0.00

0.0

2.4

—

13.30

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

-0.00

0.0

1.0

—

(42529598) SUMO-activating enzyme subunit 1 Ab [Presence] in Serum by Line blot

0.00

-0.00

0.0

1.0

—

(3002222) Hepatitis E virus IgM Ab [Presence] in Serum

0.00

-0.00

0.0

1.0

—

(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(3034603) RHD gene allele [Genotype] in Blood or Tissue by Molecular genetics method Nominal

0.00

-0.00

0.0

1.2

—

(3029023) Hepatitis E virus IgG Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.0

—

(3022689) Creatine [Moles/volume] in Urine

0.00

-0.00

0.0

1.6

—

11.76

—

(42870560) Thyrotropin [Units/volume] in Cord blood

0.00

-0.00

0.0

1.0

—

8.91

—

(37021550) Renin [Units/volume] in Plasma --upright

0.00

-0.00

0.0

2.0

—

244.16

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

-0.00

0.0

2.1

—

(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.1

—

(3022914) Cancer Ag 19-9 [Units/volume] in Serum or Plasma

0.97

-0.00

5.5

3.4

24.15

711.29

u/ml

—

(3030429) Borrelia sp DNA [Identifier] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(3006653) Thiamine [Moles/volume] in Blood

0.00

-0.00

0.0

1.0

—

132.60

—

(3012741) Chlamydophila pneumoniae IgA Ab [Titer] in Serum

0.00

-0.00

0.0

1.0

—

57.60

—

(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

4.0

—

61.43

—

(3005011) Chlamydia sp Ab [Titer] in Serum

0.00

-0.00

0.0

1.8

—

(40760109) Toxoplasma gondii IgG Ab avidity [Ratio] in Serum by Immunoassay

0.00

-0.00

0.0

1.0

—

(3026515) Parvovirus B19 IgM Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.3

—

(3045683) HLA typing for celiac disease panel - Blood or Tissue

0.00

-0.00

0.0

1.0

—

(42529582) MDA5 Ab [Presence] in Serum by Line blot

0.00

-0.00

0.0

1.0

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

-0.00

0.0

3.0

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

-0.00

0.0

1.4

—

(4024509) Urine culture

0.94

-0.00

3.6

1.7

—

(42528593) TIF1-gamma Ab [Presence] in Serum by Line blot

0.00

-0.00

0.0

1.0

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

0.90

-0.00

1.4

1.3

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.1

—

(3032567) Hepatitis B virus DNA [Units/volume] (viral load) in Serum or Plasma by NAA with probe detection

0.00

-0.00

0.0

3.6

—

(3009306) Alpha-1-Fetoprotein [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

3.84

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

-0.00

0.0

1.0

—

(40765096) Chromosome analysis panel by Banding

0.00

-0.00

0.0

1.1

—

Mortality – FinRegistry

↥

Association

Association between endpoint L12_PSORI_PUSTGEN and mortality.

Females

Parameter	HR [95% CI]	p-value
L12_PSORI_PUSTGEN	2.109 [1.55, 2.87]	< 0.001
Birth year	0.988 [0.98, 1.0]	0.011

During the follow-up period (1.1.1998 — 31.12.2019), 84 out of 289 females with L12_PSORI_PUSTGEN died.

Males

Parameter	HR [95% CI]	p-value
L12_PSORI_PUSTGEN	2.046 [1.29, 3.24]	0.002
Birth year	0.988 [0.98, 1.0]	0.01

During the follow-up period (1.1.1998 — 31.12.2019), 89 out of 268 males with L12_PSORI_PUSTGEN died.

Mortality risk

Mortality risk for people of age

years, who have L12_PSORI_PUSTGEN.

N-year risk	Females	Males
1	0.185%	0.352%
5	0.897%	2.262%
10	2.342%	5.795%
15	4.631%	11.36%
20	8.298%	18.627%

Relationships between endpoints

↥

Index endpoint: L12_PSORI_PUSTGEN – Generalized pustular psoriasis

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Generalized pustular psoriasis

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints