mucous membrane pemphigoid: Mucous membrane pemphigoid is a bullous dermatosis characterised clinically by blistering of the mucous membranes followed by scarring, and immunologically by IgG, IgA and/or C3 deposits on the epidermal basement membrane.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
86 |
4. Check minimum number of eventsNone |
86 |
5. Include endpointsNone |
86 |
6. Filter based on genotype QC (FinnGen only) |
78 |
Control definitions (FinnGen only)
- Control exclude
- L12_BULLOUS
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L12
- Name in latin
- Pemphigoides cicatricalis
Similar endpoints
↥List of similar endpoints to
Cicatricial pemphigoid
based on the number of shared cases.
Similar with more cases:
- Pemphigoid
- Bullous disorders
- Autoimmune diseases
- Used for control exclusion in common control thyroid runs
- Diseases of the skin and subcutaneous tissue
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 410 | 265 | 143 |
| Only index persons | 375 | 247 | 128 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.00 |
| Only index persons | 0.01 | 0.01 | 0.00 |
| Median age at first event (years) | |||
| Whole population | 68.93 | 68.40 | 69.73 |
| Only index persons | 67.68 | 66.93 | 69.13 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 78 | 57 | 21 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.01 |
| Median age at first event (years) | 64.99 | 62.70 | 71.18 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
No data
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 79
- Matched controls
- 790
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L12.1
ICD-10 Finland
Cicatricial pemphigoid
+∞
113.6
79
*
L12.0
ICD-10 Finland
Bullous pemphigoid
+∞
47.9
41
*
D07AD01
ATC
clobetasol; topical
12.0
28.5
44
75
ECA20
NOMESCO Finland
Biopsy of gingiva
134.0
26.6
27
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
10.8
22.7
32
47
J04BA02
ATC
dapsone; oral
281.2
21.7
21
*
L04AX01
ATC
azathioprine; systemic
37.4
19.2
24
9
L12.8
ICD-10 Finland
Other pemphigoid
+∞
17.3
16
*
L12.9
ICD-10 Finland
Pemphigoid, unspecified
+∞
17.3
16
*
D07AC01
ATC
betamethasone; topical
6.5
14.9
54
197
SBB00
NOMESCO Finland
Clinical photography of mouth and teeth
22.8
12.8
18
10
H02AB06
ATC
prednisolone; systemic
6.8
12.1
64
304
135
Kela drug reimbursment
Pemphigus
+∞
10.6
10
*
SBA00
NOMESCO Finland
Microbiological examinations
20.2
10.4
15
9
K13.79
ICD-10 Finland
Change in the oral mucosa UNS
16.3
10.2
16
12
EKA10
NOMESCO Finland
iopsy of buccal mucosa
15.1
9.3
15
12
A07AA02
ATC
nystatin; oral
6.9
6.6
16
28
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
35
7
87.44
32.77
2.7
1.3
28.39
—
u/ml
—
18
0
9
0
+∞
9.56
1.0
0.0
—
—
—
0
0
11
7
17.95
7.47
2.2
1.0
—
—
—
0
0
61
390
3.48
5.39
4.7
4.3
0.00
22.25
estimate
0.49
14
73
41
222
2.76
4.69
5.0
4.2
0.00
0.00
estimate
-0.00
14
60
60
398
3.11
4.62
4.8
4.3
0.00
0.00
estimate
-0.00
13
66
58
387
2.88
4.24
4.9
4.3
0.00
0.00
estimate
-0.00
14
70
41
235
2.55
4.03
1.9
1.8
18.25
22.67
nmol/l
1.03
34
189
10
25
4.42
3.21
1.2
3.0
0.00
0.00
g/l
—
10
25
69
540
3.19
3.15
9.4
8.7
73.55
80.93
u/l
1.60
64
512
9
21
4.69
3.10
2.1
1.3
1.09
1.18
g/l
—
9
21
49
334
2.23
2.94
6.1
4.8
34.74
35.26
g/l
0.25
44
320
48
341
2.04
2.40
2.6
2.2
91.78
99.03
pmol/l
0.51
27
175
32
198
2.04
2.34
2.7
2.1
3.06
2.91
mg/l
0.13
27
178
42
294
1.92
2.10
5.1
4.2
0.00
0.00
estimate
-0.00
11
53
40
276
1.91
2.08
3.8
3.5
2.38
2.36
mmol/l
0.21
35
254
48
354
1.91
2.02
4.5
6.5
1.22
1.22
mmol/l
0.05
41
327
64
522
2.19
2.00
4.9
4.7
15.08
15.05
pmol/l
0.03
58
475
7
23
3.24
1.84
1.7
1.7
—
—
—
0
0
72
631
2.59
1.81
7.7
7.1
39.88
39.98
mmol/mol
0.03
65
595
16
83
2.16
1.80
12.7
9.1
—
—
—
0
0
6
18
3.52
1.78
1.3
1.3
6.35
8.87
pmol/l
—
6
18
38
268
1.81
1.78
3.0
3.3
—
—
—
0
0
26
164
1.87
1.73
1.7
1.3
1.18
2.19
u/ml
—
9
37
10
46
2.34
1.47
1.5
1.8
—
—
—
0
0
49
387
1.70
1.44
5.3
6.8
1.22
1.22
mmol/l
0.00
36
339
72
647
2.27
1.38
5.2
5.6
4.72
4.62
mmol/l
0.32
67
595
19
118
1.80
1.30
2.1
1.4
—
—
—
0
0
30
215
1.64
1.24
2.5
3.4
0.27
0.55
e6/l
0.71
20
153
5
19
2.74
1.23
1.2
1.3
—
—
—
0
0
44
347
1.60
1.23
2.8
2.6
75.26
79.66
nmol/l
0.59
39
314
25
173
1.65
1.17
6.6
4.6
1.02
1.02
kg/l
0.15
17
119
5
21
2.47
1.10
1.0
3.1
178.60
192.71
%
—
5
21
69
619
1.91
1.08
4.2
4.6
1.26
1.23
mmol/l
0.13
63
561
42
336
1.53
1.05
2.9
2.9
223.68
115.58
ug/l
1.01
36
310
5
22
2.36
1.05
1.0
1.5
—
—
—
0
0
13
77
1.82
1.02
2.8
3.6
—
—
—
0
0
6
28
2.23
0.94
1.8
1.7
—
—
—
0
0
6
28
2.23
0.94
2.0
2.6
—
—
—
0
0
31
239
1.49
0.89
2.2
2.6
79.28
74.53
u/l
0.05
25
228
6
30
2.08
0.89
2.0
1.8
—
—
—
0
0
68
617
1.73
0.88
6.4
5.9
1.89
1.91
mu/l
0.05
63
561
16
106
1.64
0.87
3.5
4.5
1.03
1.08
mmol/l
0.28
16
96
5
23
2.25
0.77
1.0
1.2
—
—
—
0
0
9
56
1.68
0.75
1.6
1.4
—
—
—
0
0
27
212
1.42
0.68
3.0
3.6
0.00
0.00
estimate
-0.00
12
55
17
122
1.50
0.67
1.2
1.4
14.90
8.53
u/ml
0.19
11
39
18
131
1.48
0.67
1.3
1.3
57.26
38.91
iu/ml
—
8
50
30
256
1.28
0.42
6.2
3.9
11.14
8.89
mg/mmol
0.13
20
156
0
17
0.00
0.41
0.0
2.0
—
—
—
0
0
13
98
1.39
0.40
1.2
1.4
—
—
—
0
0
0
19
0.00
0.39
0.0
1.4
—
—
—
0
0
16
130
1.29
0.32
2.6
3.1
1.14
0.97
e6/l
—
7
67
9
116
0.75
0.30
2.7
6.7
103.56
104.20
mmol/l
—
9
116
14
115
1.26
0.25
1.5
2.0
32.57
29.78
s
0.67
14
110
12
97
1.28
0.24
1.7
1.7
—
—
—
0
0
5
37
1.37
0.24
1.2
1.6
—
—
—
0
0
41
379
1.17
0.23
2.0
2.8
—
—
—
0
0
36
330
1.17
0.23
2.3
2.6
—
—
estimate
—
0
0
5
41
1.23
0.22
1.2
1.6
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
128.45
—
0
11
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.6
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
5.4
—
125.05
—
0
14
6
50
1.22
0.20
2.3
1.1
—
—
—
0
0
15
130
1.19
0.17
2.1
1.9
—
—
—
0
0
11
94
1.20
0.14
2.7
4.0
21.74
21.72
%
—
5
45
15
134
1.15
0.12
2.1
1.6
982.78
1152.28
nmol/l
—
9
106
31
292
1.10
0.11
2.0
2.1
1.17
1.33
mmol/l
0.66
25
242
32
302
1.10
0.11
5.0
4.2
27.41
36.38
ng/l
0.45
27
223
5
46
1.09
0.10
1.6
3.0
1.34
1.40
%
—
5
46
7
65
1.08
0.08
1.3
1.3
—
—
—
0
0
13
121
1.09
0.04
2.8
3.1
0.02
2.98
e6/l
—
5
60
17
168
1.02
0.00
2.0
2.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.9
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
67.32
—
0
5
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
9.50
—
0
6
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
66.60
—
0
5
9
92
0.98
-0.00
1.9
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.6
—
42.12
—
0
5
0
8
0.00
-0.00
0.0
1.4
—
108.75
—
0
8
0
5
0.00
-0.00
0.0
1.6
—
38.41
—
0
5
0
5
0.00
-0.00
0.0
1.6
—
110.60
—
0
5
0
7
0.00
-0.00
0.0
1.4
—
43.57
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
1.20
—
0
6
0
5
0.00
-0.00
0.0
1.2
—
29.60
—
0
5
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
3.9
—
1.00
—
0
7
Mortality – FinRegistry
↥Association
Association between endpoint L12_PEMPHIGOID_CICA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_PEMPHIGOID_CICA | 1.164 [0.85, 1.6] | 0.353 |
| Birth year | 0.997 [0.99, 1.01] | 0.51 |
During the follow-up period (1.1.1998 — 31.12.2019), 67 out of 250 females with L12_PEMPHIGOID_CICA died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have L12_PEMPHIGOID_CICA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.123% | No data |
| 5 | 0.767% | No data |
| 10 | 1.93% | No data |
| 15 | 3.849% | No data |
| 20 | 6.67% | No data |
Relationships between endpoints
↥Index endpoint: L12_PEMPHIGOID_CICA – Cicatricial pemphigoid
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data