Other and unspecified papulosquamous disorders

L12_PAPULOSQUONAS

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 L44.8, L44.9
  • Hospital discharge: ICD-9 697[8-9]|6970
  • Hospital discharge: ICD-8 69799|696[5-9]
  • Cause of death: ICD-10 L44.8, L44.9
  • Cause of death: ICD-9 697[8-9]|6970
  • Cause of death: ICD-8 69799|696[5-9]

2 out of 7 registries used, show all original rules.

266

4. Check minimum number of events

None

266

5. Include endpoints

None

266

6. Filter based on genotype QC (FinnGen only)

227

Control definitions (FinnGen only)

Control exclude
L12_PAPULOSQUAMOUS

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2302 1336 944
Only index persons 1746 1046 700
Unadjusted period prevalence (%)
Whole population 0.03 0.04 0.03
Only index persons 0.03 0.04 0.03
Median age at first event (years)
Whole population 44.89 48.49 39.61
Only index persons 39.20 43.78 32.35

-FinnGen-

Key figures

All Female Male
Number of individuals 227 129 98
Unadjusted period prevalence (%) 0.05 0.05 0.04
Median age at first event (years) 48.99 47.16 51.40

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
242
Matched controls
2420
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L44.8
ICD-10 Finland
Other specified papulosquamous disorders
+∞
103.8
92
*
L44.9
ICD-10 Finland
Papulosquamous disorder, unspecified
897.1
70.8
66
*
6970A
ICD-9 Finland
Lichen planus[LICHEN RUBER PLANUS]
+∞
57.6
53
*
D07AC01
ATC
betamethasone; topical
5.5
38.5
150
552
D07XC01
ATC
betamethasone; topical
6.8
34.5
64
121
L30.9
ICD-10 Finland
Dermatitis, unspecified
4.1
22.5
83
273
L40.0
ICD-10 Finland
Psoriasis vulgaris
46.2
20.9
25
6
D07AB02
ATC
hydrocortisone butyrate; topical
3.5
20.0
110
467
E0000UV, ,
ATC
3.2
18.1
138
702
D05AX02
ATC
calcipotriol; topical
45.8
17.6
21
5
D07AD01
ATC
clobetasol; topical
3.8
16.0
59
190
E000001, ,
ATC
3.4
15.5
71
263
D07AC13
ATC
mometasone; topical
3.1
15.2
92
402
D05BB02
ATC
acitretin; oral
34.2
15.0
19
6
D05AX52
ATC
calcipotriol, combinations; topical
12.0
14.4
26
24
L40.5
ICD-10 Finland
Arthropathic psoriasis
+∞
13.7
13
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
4.0
12.3
39
112
M07.3*L40.5
ICD-10 Finland
Other psoriatic arthropathies
+∞
10.5
10
*
R06AE07
ATC
cetirizine; oral
2.4
9.9
120
708
L43.8
ICD-10 Finland
Other lichen planus
57.4
9.7
11
*
69619
ICD-8 Finland
Psoriasis and similar disorders, Psoriasis alia sive NUD (vulgaris)
+∞
9.4
9
*
D07AA02
ATC
hydrocortisone; topical
2.7
8.6
53
226
E000002, ,
ATC
3.0
8.1
39
145
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
4.2
8.1
22
56
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
2.4
8.1
68
337
E000003, ,
ATC
4.4
7.7
20
49
D07BC01
ATC
betamethasone and antiseptics; topical
3.0
7.4
35
129
ZXD10
NOMESCO Finland
Scheduled procedure
2.1
7.4
101
609
N05BB01
ATC
hydroxyzine; systemic
3.7
7.3
24
70
69698
ICD-8 Finland
Psoriasis and similar disorders, Other disorders
+∞
7.3
7
*
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
2.2
7.0
80
447
D07AB08
ATC
desonide; topical
2.8
7.0
38
151
S21
ICPC
Skin texture symptom/complaint
2.5
7.0
51
236
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.1
6.8
83
476
R03AC13
ATC
formoterol; inhalant
3.8
6.5
20
56
L40.8
ICD-10 Finland
Other psoriasis
71.7
6.5
7
*
A10BJ06
ATC
semaglutide; parenteral
4.1
6.4
18
47
69699, ,
ICD-8 Finland
+∞
6.3
6
*
L40.9
ICD-10 Finland
Psoriasis, unspecified
27.5
6.3
8
*
D07BA04
ATC
hydrocortisone and antiseptics; topical
2.9
6.2
31
118

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
23
57
4.35
8.74
1.4
1.4
303.33
297.64
ug/g
0.04
12
36
90
513
2.20
7.63
4.2
4.0
—
0.17
—
0
6
132
900
2.03
6.73
4.1
3.7
6.34
6.22
ph
0.44
61
518
123
820
2.02
6.66
5.6
4.2
35.07
65.46
e6/l
1.03
84
582
25
83
3.24
6.28
1.4
1.2
—
—
—
0
0
105
685
1.94
5.85
9.9
6.0
—
—
—
0
0
109
726
1.91
5.66
4.2
3.5
13.17
122.01
e6/l
0.66
83
558
64
359
2.06
5.41
3.9
3.2
3.76
2.89
e6/l
0.22
25
173
89
563
1.92
5.34
3.4
2.1
2.83
2.96
mg/l
0.17
81
490
48
243
2.22
5.26
1.6
1.4
—
—
—
0
0
92
593
1.89
5.18
5.3
4.5
—
—
—
0
0
82
509
1.92
5.18
5.8
4.1
93.89
90.12
%
0.76
82
503
44
217
2.26
5.13
2.2
1.7
—
—
—
0
0
130
942
1.82
4.98
7.4
4.7
35.60
35.82
g/l
0.18
122
889
52
278
2.11
4.96
1.6
1.4
211.43
504.52
titre
2.47
14
62
155
1187
1.85
4.93
16.0
9.8
4.50
4.09
e9/l
0.86
129
1023
142
1061
1.82
4.87
11.1
6.1
0.58
0.57
e9/l
0.35
117
906
17
52
3.44
4.85
1.1
1.8
229.06
293.00
mu/l
0.84
17
47
142
1065
1.81
4.77
11.2
6.1
0.04
0.04
e9/l
0.29
117
906
79
496
1.88
4.76
2.8
2.8
4.61
5.19
e6/l
0.25
73
455
40
196
2.25
4.73
11.5
7.6
—
—
—
0
0
95
635
1.82
4.67
3.9
3.3
0.21
0.31
e6/l
0.63
67
461
145
1100
1.79
4.63
11.6
6.1
0.21
0.19
e9/l
0.82
124
952
143
1083
1.78
4.57
11.2
6.1
2.08
2.03
e9/l
0.09
122
955
15
44
3.57
4.54
3.1
3.0
0.50
2.04
index
—
8
25
131
976
1.75
4.36
11.6
6.2
3.20
2.79
%
0.98
126
916
131
976
1.75
4.36
11.6
6.2
0.65
0.67
%
0.16
126
908
131
981
1.73
4.24
11.7
6.3
8.73
8.64
%
0.15
126
924
56
327
1.93
4.15
3.4
2.4
20.39
22.27
%
0.49
56
306
50
281
1.98
4.14
3.9
2.2
132.66
121.58
ug/g
0.14
44
222
62
376
1.87
4.09
3.4
2.4
11.48
12.88
umol/l
0.84
62
347
10
18
5.74
4.02
1.2
1.1
—
—
—
0
0
36
181
2.16
3.99
2.9
3.1
70.37
70.69
e9/l
0.02
23
132
122
906
1.70
3.99
2.7
2.1
100.90
95.28
pmol/l
0.44
66
457
30
141
2.29
3.91
3.7
2.0
—
—
—
0
0
6
5
12.25
3.78
1.3
1.2
—
—
—
0
0
71
460
1.77
3.75
3.0
1.4
2.49
2.25
g/l
0.40
42
266
145
1140
1.68
3.73
4.8
4.2
0.12
1.30
estimate
0.44
17
233
42
230
2.00
3.72
3.6
3.8
2.06
1.87
mmol/l
0.10
36
189
43
238
1.98
3.70
3.6
3.9
7.38
7.39
ph
0.68
25
140
129
986
1.66
3.68
11.3
6.1
54.70
57.06
%
1.32
124
942
144
1135
1.66
3.62
4.8
4.2
0.00
6.63
estimate
0.50
17
245
61
384
1.79
3.53
1.8
2.0
—
—
—
0
0
142
1120
1.65
3.52
4.8
4.1
0.00
0.00
estimate
-0.00
17
240
16
58
2.88
3.49
1.4
1.8
13.66
7.48
u/l
—
8
43
7
10
7.17
3.38
3.4
2.9
920.57
871.40
u/ml
—
7
10
13
40
3.38
3.19
1.3
1.2
—
—
—
0
0
32
169
2.03
3.13
2.7
3.4
116.60
72.51
ng/l
1.30
27
154
29
148
2.09
3.11
1.3
1.5
—
—
—
0
0
13
45
3.00
3.07
1.4
1.3
—
—
—
0
0
135
1075
1.58
3.04
8.8
6.8
1.21
1.21
mmol/l
0.16
124
930
40
233
1.86
2.96
1.5
1.5
—
—
—
0
0
90
656
1.59
2.95
10.6
6.3
—
—
—
0
0
8
17
4.83
2.94
1.6
1.1
—
—
—
0
0
14
52
2.80
2.94
1.2
1.3
—
—
—
0
0
48
297
1.77
2.92
9.1
6.8
104.94
104.01
mmol/l
0.68
48
297
63
421
1.67
2.91
3.1
3.3
497.27
536.32
mosm/kgh2o
0.77
55
375
9
22
4.21
2.91
1.2
1.2
—
—
—
0
0
34
191
1.91
2.80
11.7
6.7
1.16
1.25
mmol/l
0.34
34
186
92
683
1.56
2.75
4.8
4.0
6.09
9.33
mg/mmol
0.68
66
429
123
976
1.53
2.70
9.2
6.0
1.21
1.22
mmol/l
0.15
117
903
8
19
4.32
2.70
1.3
1.7
—
—
—
0
0
33
186
1.90
2.70
1.4
1.2
—
—
—
0
0
18
80
2.35
2.68
2.7
3.1
20.56
21.19
s
0.16
18
74
9
25
3.70
2.60
1.2
1.2
—
—
—
0
0
95
719
1.53
2.57
4.4
3.4
7.06
7.56
mmol/l
0.60
88
615
50
326
1.67
2.52
1.6
1.6
—
—
—
0
0
27
146
1.96
2.49
10.4
8.2
24.03
25.08
mmol/l
0.96
27
146
104
810
1.50
2.43
2.1
2.1
—
—
—
0
0
72
519
1.55
2.40
3.9
2.9
377.71
346.83
umol/l
1.41
66
454
13
52
2.59
2.40
1.4
1.4
—
2.79
—
0
9
49
323
1.65
2.37
2.4
2.3
30.24
29.39
s
0.34
49
313
46
301
1.65
2.28
2.7
1.9
—
—
—
0
0
6
13
4.70
2.28
1.0
1.8
14.85
13.39
umol/l
—
6
13
96
745
1.48
2.24
4.6
3.2
2.35
2.36
mmol/l
0.20
90
679
136
1131
1.46
2.22
8.1
6.7
11.88
11.86
umol/l
0.01
128
1078
117
950
1.45
2.14
13.0
12.3
0.01
0.00
e9/l
0.29
86
771
69
505
1.51
2.13
5.1
4.2
1.02
1.02
kg/l
0.38
44
340
57
400
1.56
2.12
1.4
1.3
26.95
40.12
iu/ml
0.41
16
121
14
62
2.34
2.12
1.1
1.1
—
—
—
0
0
8
25
3.27
2.11
1.8
1.3
—
—
—
0
0
58
410
1.55
2.09
5.2
3.9
344.69
280.47
ng/l
0.11
48
314
16
76
2.18
2.07
1.7
1.4
—
—
—
0
0
86
662
1.46
2.06
4.3
3.1
—
—
—
0
0
50
343
1.58
2.05
4.0
3.8
0.79
0.82
mmol/l
0.89
45
325
10
38
2.70
2.03
1.4
1.4
—
—
—
0
0
9
32
2.88
2.02
1.0
1.0
—
—
—
0
0
69
513
1.48
1.96
1.8
1.4
0.74
1.83
u/ml
1.22
17
128
6
16
3.82
1.94
1.2
1.1
—
—
—
0
0
7
22
3.24
1.89
2.0
2.1
—
—
—
0
0
9
34
2.71
1.88
1.0
1.0
—
—
—
0
0
33
210
1.66
1.83
3.5
2.6
34.41
32.58
u/l
0.15
27
165
41
278
1.57
1.77
1.4
1.2
—
—
—
0
0
12
54
2.29
1.77
3.2
1.6
—
—
—
0
0
16
82
2.02
1.74
1.1
1.1
—
—
—
0
0
59
438
1.46
1.67
3.7
2.9
2.44
2.46
mmol/l
0.74
54
388
7
25
2.85
1.66
1.1
1.2
—
—
—
0
0
117
982
1.37
1.64
13.8
13.2
1.17
1.24
inr
0.86
89
805
10
43
2.38
1.61
1.6
1.4
—
—
—
0
0
84
671
1.39
1.58
4.4
3.4
42.89
59.26
mg/l
0.50
61
437
48
346
1.48
1.58
1.7
1.7
1145.58
1206.87
nmol/l
0.20
38
260
17
93
1.89
1.56
5.9
3.6
—
—
—
0
0
83
664
1.38
1.54
3.3
2.5
—
—
—
0
0
84
674
1.38
1.53
5.0
3.9
7.40
7.40
ph
0.14
53
485
5
15
3.38
1.53
1.0
1.7
—
—
—
0
0
30
196
1.61
1.52
1.7
1.5
—
—
—
0
0
214
2004
1.59
1.50
27.1
16.2
24.68
23.99
mg/l
0.11
186
1637
33
222
1.56
1.48
1.4
2.2
330.79
378.29
nmol/l
0.75
28
214
204
1896
1.48
1.43
6.0
5.1
6.32
5.92
mmol/l
2.12
193
1752
34
234
1.53
1.39
1.6
1.3
—
—
—
0
0
17
97
1.81
1.39
2.2
4.2
36.96
36.93
°c
0.15
17
97
81
657
1.35
1.36
2.0
1.7
20.19
20.74
nmol/l
0.13
74
549
62
483
1.38
1.34
2.3
1.9
1.41
1.43
mg/l
0.02
45
378
81
661
1.34
1.30
3.5
2.6
58.71
70.81
u/l
0.58
72
622
8
34
2.40
1.30
1.4
1.3
—
—
—
0
0
16
92
1.79
1.28
1.0
1.1
—
—
—
0
0
8
36
2.26
1.25
1.3
1.2
97.82
22.95
u/l
—
8
30
9
169
0.51
1.24
3.6
3.8
—
—
—
0
0
47
355
1.40
1.22
1.4
1.4
1.13
10.10
u/ml
2.72
14
144
214
2023
1.50
1.21
28.0
19.1
139.55
139.75
mmol/l
0.55
209
1991
34
242
1.47
1.20
11.4
6.9
-0.56
1.08
mmol/l
1.41
27
203
20
126
1.64
1.19
1.2
1.2
101.53
130.30
u/ml
—
7
45
214
2026
1.49
1.16
28.3
19.1
3.96
3.97
mmol/l
0.18
209
1991
8
39
2.09
1.16
1.8
1.7
—
—
—
0
0
34
244
1.46
1.16
11.4
6.8
7.40
7.42
ph
0.22
15
151
5
20
2.53
1.15
1.2
1.1
—
—
—
0
0
28
193
1.51
1.15
6.3
4.5
2.92
0.92
%
0.81
12
66
12
65
1.89
1.15
11.6
12.7
—
—
—
0
0
60
740
0.75
1.14
3.6
3.2
—
—
—
0
0
7
30
2.37
1.13
2.0
3.1
—
—
—
0
0
17
104
1.68
1.12
1.9
1.5
0.42
0.26
mg/l
—
6
40
8
41
1.98
1.10
1.4
1.4
—
—
—
0
0
8
41
1.98
1.10
1.8
1.8
—
—
—
0
0
220
2099
1.53
1.09
31.5
21.0
75.80
76.38
umol/l
0.09
215
2080
13
74
1.80
1.09
4.9
4.2
24.58
24.70
mmol/l
0.06
13
69
197
1846
1.36
1.07
9.0
6.4
41.32
39.22
mmol/mol
1.78
190
1738
26
181
1.49
1.03
6.7
4.6
0.65
0.17
%
—
10
52
26
181
1.49
1.03
5.7
4.4
0.60
0.51
%
—
10
56
10
174
0.56
1.01
1.2
1.3
—
—
—
0
0
172
1588
1.29
0.99
5.0
4.3
14.92
14.85
pmol/l
0.16
162
1446
13
77
1.73
0.97
1.5
1.4
—
—
—
0
0
198
1866
1.34
0.95
6.5
5.4
1.93
1.92
mu/l
0.06
187
1720
7
37
1.92
0.95
1.4
1.9
—
—
—
0
0
7
37
1.92
0.95
1.6
1.5
—
—
—
0
0
217
2077
1.43
0.92
17.8
11.9
27.13
24.91
u/l
1.31
212
2029
21
144
1.50
0.91
6.0
3.3
5.32
5.09
kpa
0.75
21
139
19
128
1.53
0.89
1.3
1.4
—
30.05
—
0
12
12
185
0.63
0.79
3.2
2.7
6.29
6.06
ph
—
7
129
7
40
1.77
0.72
2.9
1.9
—
—
—
0
0
5
28
1.80
0.66
1.4
1.9
—
—
—
0
0
5
28
1.80
0.66
1.4
1.9
—
—
—
0
0
5
28
1.80
0.66
1.4
1.9
—
—
—
0
0
5
28
1.80
0.66
1.4
1.9
—
—
—
0
0
43
355
1.26
0.63
3.0
3.1
0.72
0.77
ug/l
0.13
33
230
108
981
1.18
0.61
3.3
2.8
—
—
estimate
—
0
0
26
202
1.32
0.60
1.8
1.9
—
—
—
0
0
19
142
1.37
0.56
6.5
3.3
7.40
7.42
ph
2.64
19
116
6
37
1.64
0.56
2.5
2.9
4.80
4.51
e9/l
—
6
37
54
465
1.21
0.55
7.5
5.6
—
—
—
0
0
9
63
1.44
0.53
1.2
1.2
—
—
—
0
0
199
1916
1.22
0.52
5.9
5.2
4.45
4.61
mmol/l
1.24
188
1776
21
268
0.76
0.52
1.5
1.3
—
—
—
0
0
13
92
1.44
0.51
1.9
1.9
—
—
—
0
0
9
65
1.40
0.51
2.4
1.6
—
—
—
0
0
222
2164
1.31
0.51
38.2
24.4
249.46
249.46
e9/l
0.00
214
2130
222
2165
1.31
0.50
38.2
24.3
90.90
91.00
fl
0.12
216
2151
222
2166
1.30
0.48
39.8
24.6
40.00
40.18
%
0.19
216
2150
222
2166
1.30
0.48
38.1
24.2
30.17
30.28
pg
0.43
216
2152
222
2166
1.30
0.48
38.3
24.4
7.18
6.79
e9/l
1.29
214
2121
222
2166
1.30
0.48
38.2
24.3
4.53
4.46
e12/l
1.05
214
2124
13
174
0.73
0.45
3.8
4.0
1.23
1.23
mmol/l
0.00
13
153
222
2169
1.28
0.45
38.4
24.5
134.26
134.36
g/l
0.03
217
2151
15
113
1.35
0.44
1.6
1.2
—
—
—
0
0
94
864
1.14
0.43
4.6
4.0
0.20
0.00
estimate
0.46
15
200
6
94
0.63
0.43
1.0
1.8
—
—
—
0
0
28
232
1.23
0.42
1.8
1.5
—
—
—
0
0
0
15
0.00
0.41
0.0
1.5
—
—
—
0
0
0
16
0.00
0.41
0.0
5.9
—
16.50
—
0
16
8
60
1.34
0.40
3.5
5.1
—
—
—
0
0
5
35
1.44
0.39
4.8
8.5
4.76
7.02
mmol/l
—
5
30
0
19
0.00
0.39
0.0
5.3
—
8.06
—
0
19
143
1364
1.12
0.34
4.6
3.2
59.27
43.43
u/l
1.20
135
1282
15
118
1.29
0.34
1.7
1.1
—
—
—
0
0
210
2051
1.18
0.34
17.3
14.4
—
—
—
0
0
14
111
1.28
0.30
2.1
2.3
—
—
—
0
0
13
102
1.29
0.30
3.7
2.3
0.00
0.00
estimate
—
5
37
15
122
1.24
0.27
3.0
3.0
0.55
0.64
%
0.87
15
122
15
125
1.21
0.23
3.0
3.0
1.14
1.24
%
0.13
15
125
5
39
1.29
0.23
3.6
4.2
6.82
8.52
kpa
—
5
39
5
39
1.29
0.23
3.6
4.2
4.82
4.99
kpa
—
5
39
5
39
1.29
0.23
3.6
4.2
0.68
2.47
mmol/l
—
5
26
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
4958.00
—
0
5
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.8
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.3
—
211.63
—
0
14
6
51
1.18
0.19
2.7
2.5
63.00
59.93
%
—
6
51
21
185
1.15
0.18
7.5
4.9
0.00
0.22
%
—
5
49
7
60
1.17
0.18
3.0
4.0
7.41
7.41
ph
—
7
60
194
1908
1.08
0.16
5.5
5.0
1.36
1.48
mmol/l
3.35
185
1764
9
78
1.16
0.15
2.4
1.6
—
—
—
0
0
9
81
1.12
0.15
2.4
1.6
—
—
—
0
0
9
82
1.10
0.15
2.4
1.6
—
—
—
0
0
9
83
1.09
0.15
2.4
1.6
—
—
—
0
0
185
1819
1.07
0.14
4.9
4.3
1.37
1.25
mmol/l
1.47
174
1671
14
124
1.14
0.11
2.3
3.6
—
—
—
0
0
67
644
1.06
0.11
5.6
4.2
0.00
0.00
estimate
-0.00
15
222
197
1950
1.06
0.09
7.2
5.9
2.54
2.68
mmol/l
1.38
188
1809
17
185
0.91
0.08
3.6
4.0
7.34
7.35
ph
0.12
11
128
5
60
0.83
0.08
1.0
1.2
1.45
1.59
g/l
—
5
60
8
75
1.07
0.07
2.1
2.5
—
—
—
0
0
80
820
0.96
0.07
4.8
4.1
27.21
42.37
ng/l
1.28
54
591
9
84
1.07
0.07
2.6
1.6
—
—
—
0
0
19
178
1.07
0.06
1.3
1.5
—
—
—
0
0
58
596
0.96
0.05
1.4
1.5
—
—
—
0
0
19
202
0.94
0.05
2.0
1.7
—
—
—
0
0
18
170
1.06
0.04
2.8
2.4
8.45
5.91
ug/l
0.22
18
150
13
137
0.95
0.01
1.3
1.8
3.72
3.40
mmol/l
—
6
102
63
634
0.99
0.00
3.7
3.5
0.00
0.14
estimate
0.52
15
187
85
854
0.99
0.00
2.2
2.0
1.39
1.32
mmol/l
0.33
78
722
10
104
0.96
0.00
3.1
3.2
184.30
688.05
u/ml
—
10
93
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
3.0
—
3.00
—
0
5
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
3.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
17.10
—
0
5
0
5
0.00
0.00
0.0
14.0
—
163.40
—
0
5
5
58
0.86
-0.00
4.8
2.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
61
0.98
-0.00
1.0
1.2
0.93
0.87
g/l
—
6
61
5
50
1.00
-0.00
1.2
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
5.5
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
34.49
—
0
9
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint L12_PAPULOSQUONAS and mortality.

Females

Parameter HR [95% CI] p-value
L12_PAPULOSQUONAS 1.667 [1.17, 2.38] 0.005
Birth year 0.992 [0.98, 1.0] 0.063

During the follow-up period (1.1.1998 — 31.12.2019), 87 out of 566 females with L12_PAPULOSQUONAS died.

Males

Parameter HR [95% CI] p-value
L12_PAPULOSQUONAS 1.932 [1.32, 2.84] < 0.001
Birth year 0.987 [0.98, 1.0] 0.008

During the follow-up period (1.1.1998 — 31.12.2019), 88 out of 428 males with L12_PAPULOSQUONAS died.

Mortality risk

Mortality risk for people of age

years, who have L12_PAPULOSQUONAS.

N-year risk Females Males
1 0.115% 0.391%
5 0.836% 2.163%
10 2.197% 5.375%
15 4.318% 10.143%
20 7.431% 16.83%

Relationships between endpoints

Index endpoint: L12_PAPULOSQUONAS – Other and unspecified papulosquamous disorders

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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