No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
138 |
4. Check minimum number of eventsNone |
138 |
5. Include endpointsNone |
138 |
6. Filter based on genotype QC (FinnGen only) |
118 |
Control definitions (FinnGen only)
- Control exclude
- L12_DISORDSKINAPPENDIX
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other hypertrichosis
based on the number of shared cases.
Similar with more cases:
- Hypertrichosis
- Disorders of skin appendages
- Diseases of the skin and subcutaneous tissue
- Any prescribed medicine buy
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 887 | 839 | 42 |
| Only index persons | 815 | 776 | 39 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.00 |
| Only index persons | 0.03 | 0.03 | 0.00 |
| Median age at first event (years) | |||
| Whole population | 27.97 | 28.09 | 25.14 |
| Only index persons | 28.02 | 28.20 | 24.35 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 118 | 113 | 5 |
| Unadjusted period prevalence (%) | 0.04 | 0.04 | 0.00 |
| Median age at first event (years) | 30.58 | 30.33 | 36.14 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 129
- Matched controls
- 1290
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L68.9
ICD-10 Finland
Hypertrichosis, unspecified
+∞
86.4
73
*
L68.0
ICD-10 Finland
Hirsutism
+∞
47.9
43
*
70405
ICD-8 Finland
Diseases of hair and hair follicles, Hypertrichosis
+∞
36.2
33
*
L68.8
ICD-10 Finland
Other hypertrichosis
+∞
29.3
27
*
C03DA01
ATC
spironolactone; oral
8.9
22.3
32
46
E66.8
ICD-10 Finland
Other obesity
6.6
11.4
20
35
E28.2
ICD-10 Finland
Polycystic ovarian syndrome
12.9
11.0
19
17
G03HB01
ATC
cyproterone and estrogen; oral
3.9
10.7
41
139
A10BA02
ATC
metformin; oral
3.3
8.4
41
160
E66.01
ICD-10 Finland
Obesity due to excess calories
3.7
8.3
31
102
E66.9
ICD-10 Finland
Obesity, unspecified
7.4
7.4
17
26
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.4
6.3
26
90
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
7
0
+∞
7.36
1.6
0.0
2.11
—
nmol/l
—
7
0
61
357
2.34
5.29
4.3
3.1
—
—
—
0
0
52
293
2.30
4.84
4.8
2.9
0.29
0.37
e6/l
0.19
38
204
35
177
2.34
4.10
3.9
2.6
0.83
0.90
e6/l
0.09
21
82
85
614
2.13
3.96
4.6
3.4
0.00
0.00
estimate
-0.00
20
137
57
358
2.06
3.86
3.0
2.6
2.37
2.35
mmol/l
0.67
51
332
86
629
2.10
3.82
4.8
3.5
0.00
0.00
estimate
-0.00
20
133
85
625
2.06
3.64
4.7
3.4
0.00
11.77
estimate
0.50
20
138
70
483
1.98
3.57
2.3
2.0
101.47
96.59
pmol/l
0.43
38
248
32
172
2.14
3.19
3.9
2.8
2.89
4.51
e6/l
0.60
18
78
16
63
2.76
3.09
1.3
1.3
—
—
—
0
0
22
103
2.37
3.02
4.8
4.8
—
—
—
0
0
31
168
2.11
3.01
1.6
1.6
1.55
1.34
%
1.16
25
148
104
856
2.11
2.87
5.0
3.8
12.52
9.56
mm/h
1.18
97
802
64
454
1.81
2.78
3.8
3.1
0.29
0.01
estimate
0.73
17
109
68
498
1.77
2.61
6.5
6.3
1.22
1.22
mmol/l
0.03
61
429
18
85
2.30
2.42
1.0
1.0
—
—
—
0
0
43
283
1.78
2.32
2.3
2.4
—
—
—
0
0
40
259
1.79
2.28
2.1
2.0
0.74
0.98
mg/l
0.30
26
204
119
1061
2.57
2.25
15.4
11.3
91.26
90.76
ml/min/173m2
0.08
109
936
13
57
2.42
2.05
4.2
7.0
24.67
24.59
mmol/l
0.02
13
57
22
121
1.99
2.04
8.3
5.7
1.00
1.07
mmol/l
0.47
22
107
39
263
1.69
1.90
4.9
3.8
3.80
10.24
mg/mmol
1.37
30
154
44
313
1.62
1.73
2.4
2.5
—
—
—
0
0
46
331
1.61
1.72
4.8
3.3
0.00
0.00
estimate
-0.00
18
131
12
56
2.26
1.67
1.3
1.4
—
—
—
0
0
44
316
1.60
1.65
1.8
1.6
18.30
22.26
nmol/l
1.43
35
274
36
246
1.64
1.65
1.3
1.3
10.14
30.83
iu/ml
—
7
65
8
32
2.60
1.62
1.4
1.3
—
1.00
—
0
5
14
71
2.09
1.61
1.1
1.3
—
—
—
0
0
43
309
1.59
1.61
2.2
1.9
2.68
2.61
mg/l
0.09
35
267
28
180
1.71
1.60
1.9
1.5
425.43
492.55
pmol/l
0.86
28
157
10
45
2.32
1.50
1.9
2.8
0.47
0.58
%
—
10
45
10
45
2.32
1.50
1.9
2.8
1.21
1.45
%
—
10
45
48
360
1.53
1.47
3.3
2.8
0.00
0.01
estimate
0.50
19
111
29
193
1.65
1.46
1.3
2.0
—
—
—
0
0
5
16
3.21
1.45
1.2
1.1
—
—
—
0
0
5
16
3.21
1.45
1.2
1.1
—
—
—
0
0
60
474
1.50
1.43
1.8
1.8
1.45
1.32
mmol/l
0.36
51
422
38
272
1.56
1.43
4.0
3.2
1.02
1.02
kg/l
0.20
24
170
11
54
2.13
1.37
5.8
4.6
23.54
24.24
mmol/l
0.28
11
54
6
24
2.57
1.32
1.3
1.0
—
—
—
0
0
17
101
1.79
1.27
1.8
1.9
—
—
—
0
0
32
226
1.55
1.27
1.6
2.2
—
—
—
0
0
22
142
1.66
1.24
1.8
2.0
—
—
—
0
0
102
914
1.55
1.21
3.9
3.9
—
—
—
0
0
106
959
1.59
1.19
6.8
4.8
14.27
14.45
pmol/l
0.42
101
888
45
346
1.46
1.19
1.9
1.6
—
—
—
0
0
17
104
1.73
1.16
3.2
7.3
103.76
104.74
mmol/l
0.60
17
104
5
21
2.43
1.10
9.2
1.5
9.68
5.52
pmol/l
—
5
21
7
32
2.25
1.10
2.1
1.4
—
0.01
—
0
5
76
655
1.39
1.02
10.6
9.2
3.98
3.96
e9/l
0.02
67
574
119
1122
1.78
0.95
17.6
12.3
16.90
19.46
mg/l
0.53
102
884
6
30
2.05
0.88
1.5
1.5
—
—
—
0
0
123
1175
2.01
0.87
14.7
9.9
27.44
23.48
u/l
2.22
123
1145
15
97
1.62
0.86
1.9
2.0
—
—
—
0
0
15
97
1.62
0.86
2.7
2.8
—
—
—
0
0
0
25
0.00
0.80
0.0
1.1
—
2.81
—
0
12
117
1108
1.60
0.78
8.3
5.8
1.64
1.76
mu/l
0.77
112
1043
37
297
1.34
0.74
1.7
2.0
—
—
—
0
0
114
1077
1.50
0.72
6.3
4.7
2.69
2.77
mmol/l
0.47
109
1022
9
58
1.59
0.71
1.1
1.3
—
—
—
0
0
44
368
1.30
0.66
1.2
1.3
0.56
2.03
u/ml
1.53
14
80
11
71
1.60
0.64
6.8
3.4
1.25
1.23
mmol/l
0.53
11
65
41
341
1.30
0.64
4.5
3.0
14.73
20.56
ng/l
0.92
23
180
5
30
1.69
0.62
5.6
5.0
25.64
24.21
mmol/l
—
5
30
65
576
1.26
0.61
2.7
2.6
—
—
estimate
—
0
0
16
115
1.45
0.60
1.3
1.3
191.83
109.46
u/ml
—
6
51
6
37
1.65
0.56
1.0
1.2
—
—
—
0
0
23
180
1.34
0.54
3.4
3.4
217.88
91.29
ng/l
0.26
17
94
28
229
1.28
0.49
1.2
1.3
1.03
5.64
u/ml
—
7
85
7
46
1.55
0.49
2.4
1.5
—
—
—
0
0
7
51
1.39
0.45
3.0
2.0
—
—
—
0
0
11
79
1.43
0.42
2.4
4.2
1.85
8.75
ug/l
—
6
58
5
33
1.54
0.42
1.4
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
1.5
—
13.33
—
0
15
0
15
0.00
0.41
0.0
4.6
—
84.85
—
0
15
7
103
0.66
0.41
1.6
1.5
—
—
—
0
0
111
1068
1.28
0.38
5.5
4.2
1.47
1.55
mmol/l
1.09
106
1010
44
393
1.18
0.35
2.0
1.8
—
—
—
0
0
6
45
1.35
0.34
2.5
1.5
1.15
1.15
g/l
—
6
45
6
45
1.35
0.34
2.7
1.5
0.25
0.22
g/l
—
6
45
15
122
1.26
0.28
5.2
4.2
30.44
33.31
%
—
9
81
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
24.20
—
0
6
11
91
1.23
0.18
1.5
1.3
51.49
366.60
u/ml
0.67
11
85
124
1246
0.88
0.10
28.4
19.4
134.97
132.60
g/l
1.50
124
1236
124
1245
0.90
0.10
28.4
19.5
40.71
39.78
%
2.29
124
1236
124
1245
0.90
0.10
28.1
19.2
89.65
90.35
fl
0.93
124
1236
6
56
1.07
0.09
1.0
1.1
0.80
0.89
g/l
—
6
56
6
56
1.07
0.09
1.0
1.1
1.65
1.63
g/l
—
6
56
7
66
1.06
0.08
1.9
1.9
—
—
—
0
0
7
83
0.83
0.07
1.7
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
5
0.00
-0.00
0.0
1.0
—
138.00
—
0
5
5
55
0.91
-0.00
1.6
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
94.20
—
0
5
0
6
0.00
-0.00
0.0
5.8
—
208.67
—
0
6
0
5
0.00
-0.00
0.0
3.8
—
701.20
—
0
5
0
6
0.00
-0.00
0.0
3.3
—
19.02
—
0
6
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
43.62
—
0
5
0
7
0.00
-0.00
0.0
1.0
—
20.24
—
0
7
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
1803.28
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
54.52
—
0
5
0
8
0.00
-0.00
0.0
1.1
—
0.27
—
0
8
0
5
0.00
-0.00
0.0
1.2
—
64.40
—
0
5
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
87
0.91
-0.00
1.5
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
49
1.02
-0.00
3.0
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
0
6
0.00
-0.00
0.0
3.0
—
94.00
—
0
6
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
109.83
—
0
6
Mortality – FinRegistry
↥Association
Association between endpoint L12_HYPERTICHNAS and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have L12_HYPERTICHNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: L12_HYPERTICHNAS – Other hypertrichosis
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data