Other and unspecified atrophic disorders of skin

L12_ATROPHICSKINNAS

skin atrophy: The structural changes and the signs and symptoms of chronologically aged skinand those of corticosteroid induced chronicatrophyof theskinare partially very similar.Thinningof epidermis and laxity as well as dryness, purpura and echymoses occur in both conditions.

Suggest a new description

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 L90.8, L90.9
  • Hospital discharge: ICD-9 7018X
  • Cause of death: ICD-10 L90.8, L90.9
  • Cause of death: ICD-9 7018X

2 out of 7 registries used, show all original rules.

165

4. Check minimum number of events

None

165

5. Include endpoints

None

165

6. Filter based on genotype QC (FinnGen only)

163

Control definitions (FinnGen only)

Control exclude
L12_OTHERSKINSUBCUTIS

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

No upset plot: unknown.

No upset table: unknown.

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1119 918 192
Only index persons 1014 852 162
Unadjusted period prevalence (%)
Whole population 0.02 0.03 0.01
Only index persons 0.03 0.03 0.01
Median age at first event (years)
Whole population 58.59 60.87 47.68
Only index persons 57.84 60.26 45.08

-FinnGen-

Key figures

All Female Male
Number of individuals 163 142 21
Unadjusted period prevalence (%) 0.05 0.05 0.01
Median age at first event (years) 59.03 59.58 55.30

-FinRegistry-

Age distribution of first events

0102030405060708090020406080100120140160180200220AgeIndividuals

-FinnGen-

Age distribution of first events

020304050607080051015202530354045AgeIndividuals

-FinRegistry-

Year distribution of first events

197019751980198519901995200020052010201520202022020406080100120140160180200220YearIndividuals

-FinnGen-

Year distribution of first events

197019751980198519952000200520102015202020250510152025303540YearIndividuals

-FinRegistry-

Cumulative Incidence Function

01020304050607080901000.00.10.20.30.40.50.60.70.80.91.0AgeProbability of first incidence (%)

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
165
Matched controls
1650
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L90.9
ICD-10 Finland
Atrophic disorder of skin, unspecified
+∞
117.0
98
*
L90.0
ICD-10 Finland
Lichen sclerosus et atrophicus
44.4
79.6
50
16
L90.8
ICD-10 Finland
Other atrophic disorders of skin
+∞
61.3
55
*
D07AD01
ATC
clobetasol; topical
8.2
40.2
79
167
ULA02
NOMESCO Finland
Kolposcopy
9.2
36.2
54
83
LFB00
NOMESCO Finland
Biopsy of vulva or perineum
30.2
22.7
30
12
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
6.0
15.8
31
61
7018X
ICD-9 Finland
Other hypertrophic and atrophic conditions of skin, Other specified hypertrophic and atrophic conditions of skin[ATROPHIA CUTIS ALIA DEFINITA]
+∞
14.8
14
*
XLD00
NOMESCO Finland
Sytologyspecimen from mouth of uterus
3.7
10.3
38
123
D07AC01
ATC
betamethasone; topical
2.8
9.4
81
426
E0000UV, ,
ATC
2.7
8.8
90
511
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
29.3
8.6
11
*
L43.8
ICD-10 Finland
Other lichen planus
11.7
6.9
12
11
L43
ICD-10 Finland
Lichen planus
41.8
6.8
8
*
L43.9
ICD-10 Finland
Lichen planus, unspecified
10.7
6.7
12
12
J02AC02
ATC
itraconazole; systemic
2.7
6.5
40
173
LEB00
NOMESCO Finland
Biopsy of vagina
8.7
6.5
13
16
R03BA01
ATC
beclometasone; inhalant
2.8
6.2
36
151
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.6
6.0
41
186
G01AA10
ATC
clindamycin; vaginal
2.7
6.0
38
166

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
21
48
4.87
8.91
1.2
1.3
—
—
—
0
0
91
575
2.30
6.41
2.7
2.1
—
—
—
0
0
35
162
2.47
4.88
1.3
1.3
365.71
584.00
titre
—
7
40
88
627
1.86
3.77
9.0
5.6
—
—
—
0
0
30
147
2.27
3.65
2.1
1.5
—
—
—
0
0
60
383
1.89
3.59
4.4
4.0
0.07
0.00
estimate
0.47
14
129
12
33
3.84
3.37
1.2
1.3
—
2.79
—
0
7
32
173
2.05
3.04
1.8
1.3
—
—
—
0
0
82
600
1.73
3.00
5.7
3.9
36.21
35.74
g/l
0.37
77
564
48
301
1.84
2.97
3.4
2.5
5.55
5.77
e6/l
0.06
42
276
94
716
1.73
2.96
6.1
5.0
0.06
0.00
estimate
0.48
17
128
34
192
1.97
2.87
2.7
1.8
—
—
—
0
0
63
433
1.74
2.85
2.5
2.3
62.10
55.52
u/l
0.78
58
396
93
715
1.69
2.76
5.1
3.8
0.00
0.00
estimate
-0.00
17
136
90
686
1.69
2.75
8.0
5.2
1.82
2.04
e9/l
0.60
80
613
88
668
1.68
2.73
8.0
5.1
0.57
0.56
e9/l
0.12
75
578
7
15
4.82
2.62
1.0
1.6
—
—
—
0
0
78
580
1.65
2.57
4.7
3.5
6.06
5.87
ph
—
8
38
93
725
1.65
2.53
5.1
3.8
0.00
0.00
estimate
-0.00
16
121
87
671
1.63
2.45
8.1
5.1
0.04
0.04
e9/l
0.04
75
580
125
1059
1.74
2.42
5.6
4.2
13.26
12.64
mm/h
0.18
120
969
5
8
6.40
2.39
4.2
2.1
7.98
10.33
%
—
5
8
5
8
6.40
2.39
1.2
1.4
—
—
—
0
0
7
17
4.25
2.38
1.9
1.4
—
—
—
0
0
71
524
1.62
2.37
3.8
3.1
—
—
—
0
0
118
989
1.68
2.32
5.4
4.4
—
—
—
0
0
46
305
1.70
2.30
2.9
1.7
1.42
1.13
mg/l
0.43
40
248
5
9
5.69
2.23
1.4
1.1
—
—
—
0
0
88
698
1.56
2.09
8.5
5.4
0.18
0.17
e9/l
0.29
78
613
6
15
4.11
2.06
1.0
1.1
—
—
—
0
0
6
15
4.11
2.06
10.5
1.7
57.35
51.99
%
—
6
15
67
510
1.53
1.86
5.1
3.9
186.28
62.58
e6/l
0.51
53
358
28
171
1.77
1.86
1.5
1.3
—
—
—
0
0
128
1122
1.63
1.84
5.4
4.1
15.06
14.90
pmol/l
0.33
121
1013
9
35
2.66
1.83
1.1
1.3
—
—
—
0
0
96
795
1.50
1.75
10.9
9.3
4.60
4.04
e9/l
1.07
82
688
112
959
1.52
1.72
4.6
3.7
—
—
—
0
0
21
120
1.86
1.72
4.0
3.4
—
—
—
0
0
46
327
1.56
1.72
4.9
3.9
—
—
—
0
0
80
642
1.48
1.68
7.8
5.1
58.71
57.04
%
0.60
75
602
81
652
1.48
1.68
7.9
5.3
27.39
28.48
%
0.39
75
610
46
329
1.55
1.67
5.8
4.1
1.01
1.02
kg/l
—
5
46
77
614
1.48
1.67
12.8
8.9
0.00
0.00
e9/l
0.12
64
505
13
63
2.15
1.64
3.2
2.2
—
—
—
0
0
76
606
1.47
1.64
8.0
5.2
0.77
0.67
%
0.65
71
560
58
438
1.50
1.64
4.9
3.3
205.89
192.46
e6/l
0.02
46
333
54
403
1.51
1.61
4.8
3.2
0.22
0.46
e6/l
1.11
44
297
11
50
2.29
1.61
12.7
13.0
—
—
—
0
0
28
179
1.68
1.59
3.0
1.8
289.23
103.63
ug/g
0.40
20
135
78
631
1.45
1.54
8.1
5.2
3.05
2.71
%
0.60
72
588
5
15
3.40
1.53
1.0
1.3
—
—
—
0
0
145
1332
1.73
1.50
6.4
4.9
1.71
1.86
mu/l
0.84
136
1220
17
95
1.88
1.49
1.6
1.4
—
—
—
0
0
13
66
2.05
1.48
5.2
2.3
0.78
0.66
%
0.72
13
66
21
127
1.75
1.45
4.3
3.3
—
—
—
0
0
38
271
1.52
1.39
1.4
1.7
1137.13
1216.94
nmol/l
0.27
29
199
52
396
1.46
1.38
4.3
3.1
—
—
—
0
0
39
281
1.51
1.36
3.2
2.8
504.19
508.62
mosm/kgh2o
0.04
32
248
16
91
1.84
1.34
3.8
3.5
0.50
0.26
%
—
6
23
141
1296
1.60
1.32
3.8
3.9
1.20
1.23
mmol/l
0.26
130
1186
18
107
1.77
1.32
3.6
3.7
0.71
0.79
%
—
7
34
19
115
1.74
1.31
6.5
4.4
1.15
1.34
mmol/l
0.49
19
110
30
206
1.56
1.29
1.3
1.2
—
—
—
0
0
5
18
2.83
1.29
3.4
2.2
8.26
6.18
umol/l
—
5
13
85
718
1.38
1.23
9.5
5.6
1.22
1.22
mmol/l
0.25
69
618
14
79
1.84
1.21
1.1
1.3
—
52.51
—
0
7
47
360
1.43
1.20
6.0
3.9
—
—
—
0
0
6
26
2.36
1.19
2.5
3.3
60.67
59.58
%
—
6
26
6
26
2.36
1.19
2.5
3.0
4.26
4.72
e9/l
—
6
26
6
26
2.36
1.19
1.7
1.4
8215.17
3933.95
e6/l
—
6
19
66
538
1.38
1.18
5.0
3.8
18.87
38.46
ng/l
1.73
47
385
148
1386
1.66
1.16
5.0
4.9
2.77
2.78
mmol/l
0.01
141
1272
55
437
1.39
1.14
3.6
2.1
—
—
—
0
0
145
1355
1.58
1.10
4.8
4.5
5.79
5.91
mmol/l
0.61
137
1235
145
1355
1.58
1.10
4.5
4.4
4.72
4.75
mmol/l
0.11
137
1252
5
21
2.42
1.10
1.8
2.2
—
—
—
0
0
33
241
1.46
1.08
1.2
1.3
17.83
34.34
iu/ml
—
6
78
149
1404
1.63
1.05
21.8
13.6
23.17
22.34
mg/l
0.11
122
1104
18
115
1.63
1.05
1.1
1.3
—
—
—
0
0
16
99
1.68
1.04
4.2
3.6
0.00
0.04
%
—
5
26
5
22
2.31
1.04
1.4
2.5
10.44
7.42
kpa
—
5
22
16
100
1.66
1.01
3.9
3.8
0.20
0.11
%
—
5
27
38
290
1.40
0.99
1.1
1.5
3.00
2.30
g/l
0.87
30
165
159
1533
2.02
0.98
31.2
20.2
40.27
39.49
%
1.71
147
1431
16
101
1.65
0.98
10.8
5.1
—
—
—
0
0
14
86
1.69
0.94
24.9
4.5
10.76
8.97
mmol/l
0.33
14
78
30
222
1.43
0.92
4.3
3.1
1.98
3.93
e6/l
1.37
20
113
18
120
1.56
0.90
1.5
1.3
—
—
—
0
0
12
72
1.72
0.88
5.4
4.2
25.19
25.37
mmol/l
0.07
12
72
14
88
1.65
0.87
1.5
1.6
1.50
1.62
g/l
0.09
14
78
55
459
1.30
0.80
4.6
3.8
7.41
7.40
ph
0.31
14
80
0
24
0.00
0.80
0.0
1.8
—
—
—
0
0
16
107
1.55
0.79
1.3
2.9
10.10
10.02
g/l
0.03
16
96
44
357
1.32
0.78
4.8
7.6
—
—
—
0
0
14
91
1.59
0.78
1.6
1.1
—
—
—
0
0
142
1344
1.41
0.76
4.4
4.4
1.55
1.57
mmol/l
0.27
135
1236
12
76
1.62
0.74
3.2
2.4
—
—
—
0
0
5
25
2.03
0.73
12.2
2.6
—
—
—
0
0
11
69
1.64
0.70
3.5
6.3
—
—
—
0
0
5
27
1.88
0.69
3.8
1.3
—
—
—
0
0
19
137
1.44
0.68
5.1
5.5
95.93
96.16
%
0.12
19
132
39
319
1.29
0.65
1.1
1.2
0.83
0.71
u/ml
0.30
15
81
48
405
1.26
0.63
4.3
3.1
—
—
—
0
0
5
30
1.69
0.62
1.6
2.5
23.98
25.70
mmol/l
—
5
30
11
72
1.57
0.61
11.1
2.6
23.99
24.88
mmol/l
0.47
11
72
33
269
1.28
0.57
4.7
3.6
131.72
149.43
ng/l
0.07
25
200
48
410
1.24
0.57
5.0
3.9
—
—
—
0
0
10
65
1.57
0.57
1.5
3.2
—
7.41
—
0
9
71
634
1.21
0.55
18.2
13.5
1.19
1.27
inr
0.36
25
190
66
587
1.21
0.53
2.2
2.0
87.94
97.47
pmol/l
0.94
35
266
12
164
0.71
0.48
8.8
3.2
1.88
1.74
%
0.29
12
148
36
305
1.23
0.46
1.7
1.8
414.38
471.04
pmol/l
0.65
26
250
12
87
1.41
0.43
1.2
1.3
—
—
—
0
0
47
412
1.20
0.43
3.9
2.9
5.65
6.82
mmol/l
2.31
36
344
5
31
1.63
0.43
1.2
1.0
—
—
—
0
0
0
16
0.00
0.41
0.0
2.1
—
4.69
—
0
16
20
160
1.28
0.41
7.7
5.4
104.85
104.11
mmol/l
0.39
20
160
17
133
1.31
0.40
10.9
3.9
—
—
—
0
0
15
115
1.33
0.40
1.6
1.6
—
—
—
0
0
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
47
415
1.19
0.40
4.6
3.7
14.95
9.31
mg/mmol
0.24
21
251
44
387
1.19
0.39
4.2
3.0
1686.87
232.72
mg/l
0.42
23
237
11
82
1.37
0.35
5.4
3.4
—
—
—
0
0
6
44
1.38
0.35
3.5
5.3
1.57
1.10
mmol/l
—
6
38
6
44
1.38
0.35
4.7
4.1
—
—
—
0
0
6
47
1.29
0.32
4.0
3.0
—
—
—
0
0
70
648
1.14
0.32
3.9
2.6
125.03
92.36
ug/l
1.24
63
583
7
54
1.31
0.31
5.1
4.4
1.50
1.61
%
—
7
49
7
54
1.31
0.31
5.1
4.4
0.93
0.92
%
—
7
49
148
1447
1.22
0.27
18.8
12.7
—
—
—
0
0
27
235
1.18
0.27
1.1
1.3
1.17
8.77
u/ml
1.91
11
93
19
160
1.21
0.27
5.5
5.1
10.81
12.40
kpa
1.18
19
153
19
160
1.21
0.27
5.5
5.2
5.07
5.21
kpa
0.37
19
153
14
170
0.81
0.26
5.1
2.3
14.07
7.40
umol/l
0.40
14
146
16
134
1.21
0.24
1.8
1.4
—
—
—
0
0
11
88
1.27
0.23
4.9
5.8
26.21
25.18
mmol/l
0.29
11
83
0
11
0.00
0.21
0.0
1.7
—
—
—
0
0
19
164
1.18
0.21
1.6
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
49
456
1.11
0.20
3.2
3.0
—
—
—
0
0
6
52
1.16
0.19
1.7
1.7
—
—
—
0
0
41
382
1.10
0.16
1.7
1.6
1.22
1.30
mmol/l
0.26
33
320
8
97
0.82
0.14
4.2
3.9
—
—
—
0
0
24
219
1.11
0.13
2.7
1.8
—
—
—
0
0
38
356
1.09
0.13
1.8
1.5
25.02
22.82
nmol/l
0.30
32
295
38
357
1.08
0.12
3.6
2.0
2.96
3.33
mg/l
0.48
31
307
14
124
1.14
0.11
2.2
1.7
—
—
—
0
0
18
164
1.11
0.10
2.2
3.7
2.40
8.93
ug/l
1.60
13
135
5
43
1.17
0.10
2.0
2.8
—
—
—
0
0
5
44
1.14
0.10
1.4
3.3
—
—
—
0
0
5
45
1.11
0.10
2.0
1.2
—
—
—
0
0
5
45
1.11
0.10
5.0
3.3
—
—
—
0
0
6
54
1.12
0.09
3.8
4.0
—
—
—
0
0
6
57
1.05
0.08
1.5
1.9
—
—
—
0
0
7
66
1.06
0.08
4.0
2.9
0.89
1.45
g/l
—
7
59
6
70
0.85
0.08
1.5
3.3
12.50
2009.72
u/ml
—
6
60
8
77
1.04
0.07
8.8
6.1
0.68
0.72
%
—
8
77
8
78
1.03
0.07
8.8
6.0
1.20
1.36
%
—
8
78
11
100
1.11
0.05
1.2
1.2
—
—
—
0
0
11
100
1.11
0.05
1.2
3.0
—
—
—
0
0
40
387
1.04
0.05
1.7
1.4
—
—
—
0
0
16
153
1.05
0.01
1.4
1.6
—
—
—
0
0
11
106
1.04
0.00
4.8
3.1
—
—
—
0
0
19
195
0.97
0.00
2.1
1.5
—
—
—
0
0
12
115
1.05
0.00
1.3
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.3
—
9.82
—
0
9
0
5
0.00
-0.00
0.0
3.2
—
9.20
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
0.85
—
0
7
0
6
0.00
-0.00
0.0
7.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
59.83
—
0
6
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
53
0.94
-0.00
1.8
1.3
15.46
28.53
iu/l
—
5
46
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
1.67
—
0
6
5
57
0.87
-0.00
1.2
1.2
—
—
—
0
0
9
98
0.91
-0.00
1.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
6
68
0.88
-0.00
1.0
1.1
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint L12_ATROPHICSKINNAS and mortality.

Females

Parameter HR [95% CI] p-value
L12_ATROPHICSKINNAS 1.125 [0.9, 1.41] 0.311
Birth year 0.998 [0.99, 1.01] 0.614

During the follow-up period (1.1.1998 — 31.12.2019), 117 out of 703 females with L12_ATROPHICSKINNAS died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have L12_ATROPHICSKINNAS.

N-year risk Females Males
1 0.119% No data
5 0.588% No data
10 1.835% No data
15 3.623% No data
20 6.507% No data

Relationships between endpoints

Index endpoint: L12_ATROPHICSKINNAS – Other and unspecified atrophic disorders of skin

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
loading spinner Loading data