skin atrophy: The structural changes and the signs and symptoms of chronologically aged skinand those of corticosteroid induced chronicatrophyof theskinare partially very similar.Thinningof epidermis and laxity as well as dryness, purpura and echymoses occur in both conditions.
Other and unspecified atrophic disorders of skin
DOID EFO Endpoint Browser PheWeb
L12_ATROPHICSKINNAS
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
190 |
4. Check minimum number of eventsNone |
190 |
5. Include endpointsNone |
190 |
6. Filter based on genotype QC (FinnGen only) |
176 |
Control definitions (FinnGen only)
- Control exclude
- L12_OTHERSKINSUBCUTIS
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other and unspecified atrophic disorders of skin
based on the number of shared cases.
Similar with more cases:
- Atrophic disorders of skin
- Other disorders of skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any prescribed medicine buy
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1119 | 918 | 192 |
| Only index persons | 1014 | 852 | 162 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.03 | 0.01 |
| Only index persons | 0.03 | 0.03 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 58.59 | 60.87 | 47.68 |
| Only index persons | 57.84 | 60.26 | 45.08 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 176 | 154 | 22 |
| Unadjusted period prevalence (%) | 0.05 | 0.05 | 0.01 |
| Median age at first event (years) | 60.20 | 60.86 | 55.56 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 178
- Matched controls
- 1780
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L90.9
ICD-10 Finland
Atrophic disorder of skin, unspecified
+∞
126.7
106
*
L90.0
ICD-10 Finland
Lichen sclerosus et atrophicus
51.9
94.4
57
16
L90.8
ICD-10 Finland
Other atrophic disorders of skin
+∞
67.0
60
*
D07AD01
ATC
clobetasol; topical
8.0
43.0
87
189
ULA02
NOMESCO Finland
Kolposcopy
9.3
39.3
58
88
LFB00
NOMESCO Finland
Biopsy of vulva or perineum
33.4
25.6
33
12
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
5.6
15.7
33
69
7018X
ICD-9 Finland
Other hypertrophic and atrophic conditions of skin, Other specified hypertrophic and atrophic conditions of skin[ATROPHIA CUTIS ALIA DEFINITA]
+∞
14.8
14
*
D07AC01
ATC
betamethasone; topical
3.0
12.1
93
470
XLD00
NOMESCO Finland
Sytologyspecimen from mouth of uterus
3.5
9.9
39
131
E0000UV, ,
ATC
2.6
9.1
98
567
N76.6
ICD-10 Finland
Ulceration of vulva
35.1
8.2
10
*
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.7
7.9
51
227
L43.9
ICD-10 Finland
Lichen planus, unspecified
11.6
7.4
13
12
L43.8
ICD-10 Finland
Other lichen planus
11.6
7.4
13
12
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
12.9
6.7
11
9
J02AC01
ATC
fluconazole; systemic
2.2
6.4
97
622
R03BA01
ATC
beclometasone; inhalant
2.7
6.4
39
167
L43
ICD-10 Finland
Lichen planus
27.8
6.3
8
*
LEB00
NOMESCO Finland
Biopsy of vagina
8.2
6.2
13
17
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
2.4
6.2
52
260
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
77
498
1.96
4.54
4.4
4.1
0.05
0.00
estimate
0.48
20
175
11
21
5.51
4.21
1.4
1.2
—
—
—
0
0
118
898
1.93
4.12
5.0
4.0
0.05
0.00
estimate
0.48
22
185
119
911
1.92
4.04
5.3
4.0
0.00
8.59
estimate
0.50
23
189
77
527
1.81
3.62
2.7
2.3
63.56
64.25
u/l
0.03
72
483
118
920
1.84
3.57
5.4
4.1
0.00
0.00
estimate
-0.00
21
174
94
686
1.78
3.54
4.7
3.8
0.33
0.01
estimate
0.74
15
146
99
734
1.79
3.53
6.3
4.3
35.86
35.97
g/l
0.07
93
695
145
1222
2.01
3.27
6.1
4.5
12.27
12.66
mm/h
0.14
139
1127
13
40
3.42
3.21
1.8
1.2
—
—
—
0
0
13
46
2.97
2.99
1.4
1.3
—
2.31
—
0
13
13
46
2.97
2.99
1.3
1.3
—
2.29
—
0
10
60
402
1.74
2.92
5.6
4.1
1.02
1.02
kg/l
0.11
39
267
56
372
1.74
2.80
2.7
1.7
1.29
1.20
mg/l
0.13
49
309
15
62
2.55
2.62
2.1
1.6
—
—
—
0
0
25
130
2.07
2.61
4.2
3.3
51.00
62.61
ml/min/173m2
—
10
61
8
22
3.76
2.39
1.4
1.1
—
—
—
0
0
43
277
1.73
2.36
3.8
2.2
13.98
12.59
umol/l
0.56
38
256
112
920
1.59
2.27
11.3
9.8
4.54
3.98
e9/l
1.30
97
798
43
280
1.71
2.27
3.9
3.1
0.71
1.06
e6/l
0.71
29
140
147
1298
1.76
2.17
6.2
4.6
14.99
14.90
pmol/l
0.17
141
1185
31
189
1.78
2.05
8.3
5.5
5.10
5.15
kpa
0.11
31
182
31
189
1.78
2.05
8.3
5.5
11.41
12.30
kpa
0.53
31
182
5
11
4.64
1.95
1.0
1.4
—
—
—
0
0
48
335
1.59
1.92
2.0
1.4
—
—
—
0
0
121
1033
1.54
1.90
3.1
3.1
42.73
43.01
u/l
0.01
114
960
13
59
2.30
1.89
1.3
1.6
4.04
7.74
iu/ml
—
5
16
7
24
2.99
1.74
2.9
1.6
—
—
—
0
0
5
13
3.92
1.72
1.2
1.2
—
—
—
0
0
27
167
1.73
1.71
3.9
3.4
—
—
—
0
0
10
40
2.59
1.69
1.3
1.4
—
—
—
0
0
18
98
1.93
1.69
10.3
5.5
25.01
25.02
mmol/l
0.00
18
93
6
19
3.23
1.67
1.0
1.2
—
—
—
0
0
17
93
1.92
1.58
5.2
6.4
1.05
1.26
%
0.54
17
93
5
15
3.40
1.53
1.0
1.2
—
—
—
0
0
5
15
3.40
1.53
1.0
1.2
—
—
—
0
0
5
15
3.40
1.53
1.0
1.2
—
—
—
0
0
77
620
1.43
1.51
3.0
3.3
2.35
2.36
mmol/l
0.35
71
566
61
471
1.45
1.50
5.5
3.3
0.18
0.57
e6/l
2.43
51
341
78
631
1.42
1.48
5.3
3.9
17.29
121.88
ng/l
0.64
58
461
6
22
2.79
1.44
1.3
1.0
—
—
—
0
0
166
1560
1.95
1.44
24.9
15.5
23.04
22.04
mg/l
0.14
143
1283
156
1442
1.66
1.42
4.3
4.3
1.24
1.22
mmol/l
0.13
145
1330
171
1633
2.20
1.39
16.9
12.1
23.77
23.65
u/l
0.05
171
1579
16
90
1.85
1.38
4.6
5.4
25.52
24.72
mmol/l
0.45
16
90
5
17
2.99
1.37
1.0
1.2
—
—
—
0
0
5
18
2.83
1.29
3.6
2.4
8.26
6.07
umol/l
—
5
13
160
1497
1.68
1.27
7.6
5.8
1.75
1.88
mu/l
0.76
151
1389
8
36
2.28
1.26
1.0
1.1
—
—
—
0
0
63
503
1.39
1.26
4.1
3.3
0.00
0.00
estimate
-0.00
14
151
18
109
1.72
1.24
2.4
2.5
—
31.04
—
0
5
108
943
1.37
1.23
3.8
3.1
—
—
—
0
0
39
287
1.46
1.21
1.5
1.7
1137.13
1192.65
nmol/l
0.18
29
212
8
39
2.10
1.17
1.4
1.1
—
—
—
0
0
8
39
2.10
1.17
2.8
1.5
—
—
—
0
0
5
20
2.54
1.16
1.0
1.5
3.20
188.34
u/ml
—
5
20
18
115
1.63
1.04
1.7
1.5
—
—
—
0
0
15
91
1.71
1.04
5.3
2.3
0.71
0.61
%
0.97
15
91
7
34
2.10
1.04
2.9
1.6
—
—
—
0
0
29
208
1.47
1.03
7.1
5.4
104.38
103.85
mmol/l
0.30
29
208
90
778
1.32
1.03
3.5
2.6
—
—
estimate
—
0
0
14
86
1.68
0.94
11.6
6.5
16.16
15.77
%
0.24
14
81
13
80
1.67
0.87
10.7
2.7
24.61
24.87
mmol/l
0.10
13
80
40
314
1.35
0.87
1.4
1.3
17.37
32.47
iu/ml
—
9
101
34
260
1.38
0.87
4.6
3.3
2.19
3.92
e6/l
1.17
22
120
8
46
1.77
0.83
1.1
1.2
—
—
—
0
0
46
376
1.30
0.76
2.3
3.0
2.45
2.46
mmol/l
0.27
40
338
9
54
1.70
0.76
1.9
1.6
—
—
—
0
0
5
24
2.11
0.75
1.8
1.4
—
—
—
0
0
7
38
1.88
0.74
9.0
2.2
4.97
3.87
g/l
—
7
38
9
56
1.64
0.73
1.4
1.4
—
—
—
0
0
95
853
1.24
0.72
11.6
6.2
1.22
1.22
mmol/l
0.22
80
738
7
40
1.78
0.72
2.9
1.5
—
—
—
0
0
158
1510
1.41
0.71
24.0
15.4
78.65
79.29
ml/min/173m2
0.15
152
1392
162
1555
1.47
0.71
6.1
5.9
2.71
2.73
mmol/l
0.13
157
1440
25
189
1.38
0.69
2.9
1.8
—
—
—
0
0
172
1678
1.74
0.64
36.4
23.8
91.66
91.09
fl
0.92
172
1659
172
1679
1.72
0.64
36.9
24.1
40.13
39.63
%
1.05
172
1660
172
1679
1.72
0.64
36.8
24.0
132.50
131.76
g/l
0.32
172
1659
159
1527
1.39
0.63
5.5
5.2
4.71
4.73
mmol/l
0.09
152
1418
158
1517
1.37
0.62
5.6
5.1
5.80
5.91
mmol/l
0.52
150
1388
12
80
1.54
0.61
2.3
1.8
—
—
—
0
0
26
203
1.33
0.60
2.5
1.8
—
—
—
0
0
16
116
1.42
0.56
1.6
1.3
—
—
—
0
0
6
38
1.60
0.55
1.0
1.4
—
—
—
0
0
22
170
1.34
0.55
11.6
7.5
—
—
—
0
0
32
265
1.25
0.49
3.1
1.8
—
—
—
0
0
157
1517
1.30
0.47
5.2
5.1
1.54
1.57
mmol/l
0.33
151
1403
7
49
1.45
0.46
2.1
2.7
24.40
25.59
mmol/l
—
7
49
47
411
1.20
0.44
1.2
1.2
0.76
1.01
u/ml
0.28
21
103
5
32
1.58
0.42
1.6
1.5
—
—
—
0
0
5
32
1.58
0.42
1.6
1.5
—
—
—
0
0
5
33
1.53
0.41
1.4
1.5
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
87
805
1.16
0.41
3.2
2.5
85.03
80.33
nmol/l
0.84
76
727
36
309
1.21
0.41
1.6
1.6
—
—
—
0
0
5
34
1.48
0.40
6.0
4.8
26.20
36.18
mg/l
—
5
24
0
18
0.00
0.40
0.0
1.6
—
40.11
—
0
18
0
19
0.00
0.39
0.0
1.2
—
15.03
—
0
19
5
36
1.40
0.38
3.4
1.6
—
—
—
0
0
46
409
1.17
0.36
4.0
2.1
—
—
—
0
0
37
323
1.18
0.35
4.8
3.6
126.50
177.59
ng/l
0.20
26
241
6
44
1.38
0.35
3.3
1.5
—
—
—
0
0
12
91
1.34
0.34
2.3
1.6
—
—
—
0
0
13
101
1.31
0.32
2.7
2.0
—
—
—
0
0
7
54
1.31
0.31
4.1
1.7
—
—
—
0
0
81
759
1.12
0.29
2.4
2.1
93.29
97.79
pmol/l
0.38
43
359
39
348
1.15
0.29
1.8
1.8
464.62
466.57
pmol/l
0.01
29
290
48
436
1.14
0.28
3.7
2.1
2.78
3.22
mg/l
0.75
40
379
73
685
1.11
0.25
2.0
1.9
1.40
1.30
mmol/l
0.38
63
575
135
1312
1.12
0.22
29.1
19.6
13.84
13.72
%
0.41
135
1295
5
40
1.26
0.22
1.4
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
2.9
—
—
—
0
0
11
89
1.25
0.21
7.1
6.5
0.50
0.68
%
0.96
11
89
11
89
1.25
0.21
2.3
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
10.90
—
0
7
6
50
1.21
0.20
1.7
1.8
—
—
—
0
0
14
118
1.20
0.20
1.1
1.2
180.20
128.10
u/ml
—
5
52
6
53
1.14
0.19
1.2
1.2
—
—
—
0
0
7
59
1.19
0.18
4.1
1.7
—
—
—
0
0
32
293
1.11
0.17
1.3
1.3
1.04
13.01
u/ml
2.67
14
114
83
803
1.06
0.12
4.3
3.0
124.65
93.47
ug/l
1.43
76
739
6
56
1.07
0.09
1.3
1.1
—
—
—
0
0
7
83
0.84
0.07
1.6
3.5
11.43
2446.73
u/ml
—
7
72
12
109
1.11
0.06
9.8
5.1
24.26
21.59
%
—
5
57
56
547
1.03
0.04
5.6
3.9
13.96
7.78
mg/mmol
0.36
28
324
21
200
1.06
0.04
2.3
4.2
2.28
9.46
ug/l
2.36
16
164
19
181
1.06
0.03
5.2
5.3
245.74
300.68
u/l
0.59
19
165
53
524
1.02
0.00
2.0
1.7
24.80
22.18
nmol/l
0.53
47
439
10
96
1.04
0.00
1.1
1.1
—
—
—
0
0
15
152
0.99
0.00
2.7
1.7
—
—
—
0
0
5
55
0.91
0.00
1.2
1.2
—
—
—
0
0
9
90
1.00
-0.00
1.8
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
16
160
1.00
-0.00
2.7
1.9
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
22.48
—
0
5
0
7
0.00
-0.00
0.0
1.0
—
0.24
—
0
7
0
6
0.00
-0.00
0.0
1.2
—
9.17
—
0
6
0
7
0.00
-0.00
0.0
1.9
—
68.67
—
0
7
0
9
0.00
-0.00
0.0
1.3
—
29.14
—
0
9
0
5
0.00
-0.00
0.0
3.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint L12_ATROPHICSKINNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_ATROPHICSKINNAS | 1.125 [0.9, 1.41] | 0.311 |
| Birth year | 0.998 [0.99, 1.01] | 0.614 |
During the follow-up period (1.1.1998 — 31.12.2019), 117 out of 703 females with L12_ATROPHICSKINNAS died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have L12_ATROPHICSKINNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.119% | No data |
| 5 | 0.588% | No data |
| 10 | 1.835% | No data |
| 15 | 3.623% | No data |
| 20 | 6.507% | No data |
Relationships between endpoints
↥Index endpoint: L12_ATROPHICSKINNAS – Other and unspecified atrophic disorders of skin
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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