Apocrine sweat disorders, other sweat gland disorders

L12_APOCRINESWEAT

sweat gland disease: disorders or sweat glands

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — L75 Hospital discharge: ICD-9 — 7058B\|7058X\|7059 Hospital discharge: ICD-8 — 705 Hospital discharge: excluded ICD-8 — 705[0-1] Cause of death: ICD-10 — L75 Cause of death: ICD-9 — 7058B\|7058X\|7059 Cause of death: ICD-8 — 705 Cause of death: excluded ICD-8 — 705[0-1] 2 out of 7 registries used, show all original rules.	163
4. Check minimum number of events None	163
5. Include endpoints None	163
6. Filter based on genotype QC (FinnGen only)	150

Control definitions (FinnGen only)

Control exclude: L12_DISORDSKINAPPENDIX

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: L60-L75
Name in latin: Morbositates glandularum sudoriferarum apocrinarum

NAME	L12_APOCRINESWEAT
CONTROL_EXCLUDE	L12_DISORDSKINAPPENDIX
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	L75
HD_ICD_9	7058B\|7058X\|7059
HD_ICD_8	705
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL	705[0-1]
COD_MAINONLY
COD_ICD_10	L75
COD_ICD_9	7058B\|7058X\|7059
COD_ICD_8	705
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL	705[0-1]
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Apocrine sweat disorders, other sweat gland disorders based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1190	653	525
Only index persons	958	562	396
Unadjusted period prevalence (%)
Whole population	0.02	0.02	0.01
Only index persons	0.02	0.02	0.02
Median age at first event (years)
Whole population	34.11	34.20	33.83
Only index persons	32.47	32.89	31.89

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	150	102	48
Unadjusted period prevalence (%)	0.03	0.04	0.02
Median age at first event (years)	33.73	33.18	34.90

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
152: Matched controls
1520

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

70591

ICD-8 Finland

Diseases of sweat glands, Hidrosadenitis

+∞

49.8

L73.2

ICD-10 Finland

Hidradenitis suppurativa

74.0

27.1

70590

ICD-8 Finland

Diseases of sweat glands, Hidrosis

+∞

22.4

L75.9

ICD-10 Finland

Apocrine sweat disorder, unspecified

+∞

19.2

L75.8

ICD-10 Finland

Other apocrine sweat disorders

+∞

14.8

7058X

ICD-9 Finland

Disorders of sweat glands, Other specified disorders of sweat glands[MUU HIKIRAUHASSAIRAUS]

+∞

12.7

QBE05

NOMESCO Finland

Excision of sweat glands or sweat gland bearing skin from trunk

+∞

10.5

70599

ICD-8 Finland

Diseases of sweat glands, Other

+∞

10.5

SPAT1144

SPAT

Treatment of reopened or infected surgical wound

5.9

10.4

7058C

ICD-9 Finland

Disorders of sweat glands, Other specified disorders of sweat glands[HIDRADENITIS SUPPURATIVA]

+∞

9.5

S10

ICPC

Boil/carbuncle

4.6

7.5

L02.2

ICD-10 Finland

Cutaneous abscess, furuncle and carbuncle of trunk

6.9

7.5

L72.1

ICD-10 Finland

Trichilemmal cyst

6.2

7.4

J44.8

ICD-10 Finland

Other specified chronic obstructive pulmonary disease

3.7

7.3

9752

FHL

Surgical treatment of hyperhidrosis

+∞

7.3

J01DA09

ATC

[U] cefadroxil

2.6

7.3

282

9734

FHL

Excision and local plastic or associated free skin grafting

72.8

6.5

J01FF01

ATC

clindamycin; systemic

2.5

6.4

296

J01AA07

ATC

tetracycline; systemic

3.0

6.1

115

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3007853) Bacteria identified in Skin by Aerobe culture

140

3.17

7.78

2.2

1.7

—

(3037522) Nuclear Ab [Titer] in Serum

184

2.42

4.85

1.7

1.4

706.67

548.33

titre

—

(3042936) Bacteria identified in Isolate by Culture

194

2.28

4.27

2.5

2.0

—

(3032080) INR in Blood by Coagulation assay

638

1.90

3.65

15.0

10.9

1.23

1.19

inr

0.26

523

(3019225) pH of Specimen

119

2.32

3.27

4.0

3.9

7.39

7.34

1.29

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

101

2.38

3.11

1.9

1.4

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

123

1029

2.02

2.96

12.0

7.7

81.10

79.09

u/l

0.19

113

973

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

426

1.77

2.87

4.4

2.5

57.00

68.51

u/l

0.52

395

(3021960) Folate [Moles/volume] in Serum or Plasma

400

1.78

2.86

1.7

20.11

22.51

nmol/l

0.55

326

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

621

1.74

2.84

2.7

2.4

78.21

78.56

nmol/l

0.03

559

(3022313) Gas panel - Capillary blood

2.70

4.6

3.2

—

(3009508) Creatinine [Moles/volume] in Urine

470

1.71

2.65

3.4

3.1

7.21

7.68

mmol/l

0.37

386

(3027945) Reticulocytes/Erythrocytes in Blood

160

2.00

2.63

1.9

3.3

1.87

1.83

0.08

141

(3023368) Bacteria identified in Blood by Culture

356

1.75

2.61

5.6

4.4

—

(3006315) Basophils [#/volume] in Blood

692

1.69

2.55

8.8

5.6

0.05

0.04

e9/l

0.66

578

(3012095) Magnesium [Moles/volume] in Serum or Plasma

233

1.84

2.53

4.9

2.8

0.75

0.80

mmol/l

1.73

221

(3017732) Neutrophils [#/volume] in Blood

170

1.95

2.52

3.3

4.06

5.64

e9/l

0.54

147

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

2.81

2.51

2.3

2.2

—

(42870588) Differential panel, method unspecified - Blood

431

1.69

2.49

8.3

5.3

—

(3044640) Blood type and Crossmatch panel - Blood

441

1.69

2.46

3.5

2.3

—

(3001604) Monocytes [#/volume] in Blood

687

1.67

2.44

8.9

5.6

0.60

0.56

e9/l

0.95

577

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

639

1.66

2.42

3.6

2.7

—

estimate

—

(3013115) Eosinophils [#/volume] in Blood

719

1.66

2.39

9.2

5.7

0.20

0.18

e9/l

0.38

618

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

4.26

2.39

1.0

1.2

—

(40768804) Tissue Pathology biopsy report

536

1.65

2.39

2.4

2.2

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

105

862

1.71

2.37

4.7

3.2

65.56

47.78

u/l

0.79

816

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

3.35

2.35

1.8

1.1

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

315

1.71

2.30

2.0

1.7

0.87

1.20

mg/l

0.70

260

(3012516) Albumin [Mass/volume] in Urine

457

1.65

2.29

3.3

3.2

21.43

64.73

mg/l

2.02

291

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

2.81

2.26

2.5

2.0

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

122

1052

1.81

2.22

4.4

14.96

14.82

pmol/l

0.28

108

957

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

612

1.61

2.17

2.5

2.0

88.05

99.75

pmol/l

1.40

287

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

329

1.67

2.15

3.1

2.3

—

(3019198) Lymphocytes [#/volume] in Blood

701

1.61

2.14

9.1

5.6

2.59

1.92

e9/l

0.60

612

(3022145) Colonoscopy Study observation

164

1.87

2.13

1.2

1.3

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

773

1.61

2.10

11.6

9.4

4.59

4.08

e9/l

1.31

656

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

5.13

2.08

1.0

1.1

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.20

2.05

3.1

1.6

—

(3000067) Parathyrin.intact [Mass/volume] in Serum or Plasma

106

2.02

2.9

3.1

89.00

72.24

ng/l

0.34

(3026782) Osmolality of Urine

251

1.69

1.94

4.2

3.3

533.09

515.48

mosm/kgh2o

0.14

217

(3020682) Albumin/Creatinine [Ratio] in Urine

473

1.57

1.92

4.4

3.7

4.12

10.35

mg/mmol

1.71

280

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

139

1.86

1.89

1.6

1.8

1.73

1.43

1.30

121

(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction

155

1.82

1.88

4.0

5.2

212.76

248.59

u/l

1.63

145

(3025941) Bacteria identified in Stool by Culture

2.17

1.88

1.1

1.3

—

(21494890) Protein electrophoresis panel - 24 hour Urine

4.27

1.84

1.2

1.6

—

(1616796) Gas panel - Central venous blood

3.14

1.82

3.3

2.4

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

232

1.66

1.76

2.7

1.9

—

(3002256) Pathology report gross observation

175

1.74

1.73

1.4

1.3

—

(3002179) Metamyelocytes/Leukocytes in Blood

120

1.87

1.73

7.5

4.7

0.17

0.50

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

482

1.52

1.73

3.9

3.1

2.33

2.36

mmol/l

0.62

437

(3035637) Corticotropin [Mass/volume] in Plasma

3.94

1.73

2.0

1.5

119.02

16.74

ng/l

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

2.60

1.70

1.6

1.4

—

(3044941) Cell count panel - Synovial fluid

3.24

1.68

2.2

1.1

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

323

1.56

1.63

1.5

1.2

0.53

2.07

u/ml

1.23

(40768797) Stomach Pathology biopsy report

189

1.66

1.55

1.4

1.2

—

(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum

1.95

1.46

2.3

2.4

—

8.10

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

2.39

1.46

1.6

1.3

—

(3001334) Neutrophil cytoplasmic Ab [Units/volume] in Serum

2.39

1.46

1.8

1.4

—

(4195642) Thrombophilia screening test

3.19

1.45

1.2

1.1

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

3.19

1.45

1.4

1.1

31.80

32.94

—

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

176

1.65

1.44

4.7

4.6

32.00

33.48

0.24

108

(3004588) Protein electrophoresis panel - Serum or Plasma

1.89

1.43

6.5

2.6

—

(3030366) Cystatin C [Mass/volume] in Serum or Plasma

2.33

1.43

1.2

2.0

1.48

1.51

mg/l

—

(3017181) Myelocytes/Leukocytes in Blood

128

1.74

1.42

8.3

4.6

0.44

0.97

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

2.48

1.41

1.0

1.6

—

(43055120) Cytomegalovirus DNA [Units/volume] (viral load) in Serum or Plasma by NAA with probe detection

2.48

1.41

3.0

5.5

—

176.80

—

(3007164) IgA [Mass/volume] in Serum or Plasma

289

1.52

1.40

3.0

1.3

2.19

2.32

g/l

0.21

160

(3037467) Urinalysis macro (dipstick) panel - Urine

104

905

1.47

1.39

6.3

4.8

—

1.61

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

3.00

1.37

1.6

1.7

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

3.00

1.37

1.6

1.7

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

3.00

1.37

1.0

1.1

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

3.00

1.37

1.6

1.7

—

(3013707) Erythrocyte sedimentation rate [Velocity] in Red Blood Cells by Westergren method

114

1012

1.51

1.36

6.2

4.4

14.42

11.83

mm/h

0.89

102

938

(3048689) Calprotectin [Mass/mass] in Stool

171

1.63

1.35

2.4

1.9

121.90

101.15

ug/g

0.13

133

(3044927) Protein electrophoresis panel - Urine

2.84

1.29

1.2

1.1

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

2.84

1.29

1.6

1.7

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

2.84

1.29

1.6

1.7

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

2.84

1.29

1.6

1.7

—

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

2.84

1.29

1.4

—

(3021440) Promyelocytes/Leukocytes in Blood

116

1.73

1.29

8.3

4.9

0.00

0.15

—

(40761536) Microorganisms panel - Urine sediment

1.85

1.28

5.4

4.1

—

(3025159) Blasts/Leukocytes in Blood

125

1.69

1.25

9.6

5.3

0.00

0.03

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

424

1.42

1.23

5.1

3.4

1460.86

1176.83

ng/l

0.33

359

(3010421) pH of Blood

2.23

1.23

3.3

2.9

7.41

7.42

—

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

625

1.39

1.21

7.0

5.9

1.22

mmol/l

0.19

580

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

704

1.39

1.21

9.5

6.7

1.22

mmol/l

0.14

620

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

271

1.48

1.21

1.9

1.8

372.13

452.56

pmol/l

1.52

227

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

343

1.44

1.20

3.0

2.1

2.83

2.79

mg/l

0.04

290

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

551

1.39

1.16

7.3

4.0

24.19

34.55

ng/l

0.65

402

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.85

1.15

1.6

1.2

—

(40760892) CBC W Ordered Manual Differential panel - Blood

320

1.43

1.12

8.5

4.7

—

(36660697) Celiac disease serology panel - Serum

105

1.70

1.11

1.2

—

(3016888) Borrelia burgdorferi IgG Ab [Units/volume] in Serum

1.80

1.06

1.2

1.3

—

54.50

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

2.31

1.04

1.2

1.1

—

(1761482) Bacteria [#/volume] in Urine by Culture

2.05

1.01

5.1

6.8

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

125

1.59

1.00

5.7

3.3

—

(3038515) Glucose [Moles/volume] in Venous blood

1.99

0.98

4.6

3.3

6.87

7.43

mmol/l

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

134

1.57

0.98

1.4

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

133

1245

1.55

0.97

6.5

5.4

1.52

1.91

mu/l

4.87

124

1144

(3019309) Folate [Moles/volume] in Red Blood Cells

221

1.45

0.95

2.3

1.7

1154.63

1202.32

nmol/l

0.11

166

(3037756) Immunofixation for Serum or Plasma

2.27

0.94

1.7

2.1

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

178

1.48

0.94

2.8

1.7

—

(3041096) Erythrocytes [Presence] in Urine by Automated

377

1.36

0.92

5.0

3.8

0.17

0.00

estimate

0.48

108

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.71

0.91

1.2

1.4

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

1.95

0.90

1.8

2.6

159.00

177.50

—

(3003327) Ova and parasites identified in Stool by Light microscopy

1.84

0.90

1.8

1.5

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

522

1.32

0.87

5.0

4.0

0.00

estimate

-0.00

109

(3008037) Lactate [Moles/volume] in Venous blood

1.86

0.87

4.3

3.2

1.86

1.61

mmol/l

—

(3012544) pH of Venous blood

138

1.52

0.87

4.3

3.4

7.37

7.39

0.77

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

131

1230

1.47

0.86

5.0

4.4

1.51

1.30

mmol/l

1.95

119

1125

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

485

1.32

0.86

3.7

3.1

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.72

0.81

2.8

2.5

—

(3034770) Mitochondria Ab [Titer] in Serum

1.85

0.80

1.5

1.1

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.65

0.77

1.2

1.0

—

(3027315) Oxygen [Partial pressure] in Blood

2.12

0.75

4.0

2.5

8.46

8.76

kpa

—

(3013290) Carbon dioxide [Partial pressure] in Blood

2.12

0.75

4.0

2.5

4.56

4.98

kpa

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

178

1.41

0.74

1.6

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

206

1.38

0.72

1.6

1.7

—

(3004383) Neutrophil cytoplasmic Ab.classic [Titer] in Serum by Immunofluorescence

1.95

0.71

1.2

1.6

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

154

1.42

0.69

4.9

7.1

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

1.70

0.69

1.3

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

273

1.32

0.66

1.4

1.3

24.91

30.72

iu/ml

0.25

(3005322) IgE [Units/volume] in Serum or Plasma

1.54

0.65

1.2

540.61

722.06

u/ml

0.13

(3002582) Erythrocytes [#/volume] in Urine

453

1.26

0.64

3.9

3.3

38.48

30.19

e6/l

0.26

332

(3049717) Cytology report of Urine Cyto stain

1.60

0.61

3.9

3.0

—

(40761511) CBC panel - Blood by Automated count

140

1348

1.49

0.60

21.4

13.6

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

0.00

0.59

0.0

1.7

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

143

1.38

0.56

2.4

1.6

—

(40758558) Short blood count panel - Blood

414

1.23

0.53

8.5

6.0

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

1.58

0.49

1.3

1.6

—

4.14

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

247

1.27

0.49

1.5

1.3

3.54

11.41

u/ml

1.36

(3001122) Ferritin [Mass/volume] in Serum or Plasma

632

1.20

0.48

3.5

2.8

100.09

114.13

ug/l

0.48

581

(3029937) Albumin [Presence] in Urine by Test strip

389

1.22

0.48

4.4

3.8

0.00

estimate

-0.00

129

(40764999) Glomerular filtration rate [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)/1.73 sq M

132

1268

1.31

0.48

27.1

15.5

79.49

79.60

ml/min/173m2

0.02

123

1160

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

134

1290

1.33

0.48

5.8

5.2

4.47

4.69

mmol/l

1.94

121

1194

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

135

1302

1.33

0.46

27.4

15.6

21.27

23.44

mg/l

0.32

122

1071

(3030467) Casts [#/volume] in Urine by Automated count

391

1.21

0.46

3.6

3.3

1.31

0.42

e6/l

0.83

268

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

129

0.68

0.45

1.3

1.4

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

129

1239

1.27

0.44

8.0

6.6

39.80

39.41

mmol/mol

0.19

118

1159

(40761535) Cells panel - Urine sediment

0.62

0.43

2.2

3.1

—

(3002385) Erythrocyte [DistWidth] in Red Blood Cells

105

1107

0.83

0.43

30.6

19.3

14.05

13.66

2.35

105

1098

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

168

1.29

0.43

2.8

1.8

—

(1761868) Lipid panel - Serum or Plasma

511

1.18

0.42

3.4

3.3

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.41

0.0

1.0

—

(3027801) Oxygen [Partial pressure] in Arterial blood

160

1.29

0.41

3.4

8.0

12.21

12.82

kpa

0.20

153

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

160

1.29

0.41

3.4

8.0

4.92

5.20

kpa

0.97

153

(4024509) Urine culture

1.35

0.41

2.1

2.0

—

(1002224) Polysomnography panel

1.35

0.41

1.0

1.1

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

1.49

0.40

1.4

1.7

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

0.00

0.40

0.0

1.1

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

132

1275

1.27

0.39

6.7

5.2

6.23

5.96

mmol/l

1.03

120

1177

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

135

1308

1.29

0.39

6.6

6.0

2.53

2.70

mmol/l

1.64

124

1203

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

265

0.80

0.38

4.0

4.3

19.46

22.43

0.40

130

(3026008) Bacteria identified in Urine by Culture

437

1.18

0.38

4.9

3.3

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

1.48

0.36

1.0

1.9

—

(3016502) Oxygen saturation in Arterial blood

145

1.27

0.35

4.3

8.3

95.66

96.20

0.19

140

(3018095) Leukocytes [#/volume] in Urine

509

1.16

0.34

4.1

112.64

48.01

e6/l

0.48

344

(3008898) HLA-B27 [Presence]

1.32

0.33

1.2

1.1

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.36

0.31

1.1

1.4

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.33

0.31

1.7

1.6

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

587

0.88

0.29

1.9

1.60

1.38

mmol/l

0.86

489

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

0.69

0.26

1.4

1.1

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

132

1287

1.19

0.26

5.6

5.1

1.43

1.52

mmol/l

1.83

120

1179

(3019977) pH of Arterial blood

161

1.21

0.25

4.2

8.0

7.41

7.42

0.06

(3019060) Gas panel - Arterial blood

1.30

0.25

1.8

4.8

—

(3018677) aPTT in Platelet poor plasma by Coagulation assay

209

1.18

0.24

1.8

1.9

30.46

28.63

0.71

203

(3035933) Granulocytes/Leukocytes in Blood

1.36

0.24

5.0

2.1

52.40

61.20

—

(40766189) Gliadin peptide IgG Ab [Units/volume] in Serum by Immunoassay

1.36

0.24

1.2

1.1

—

14.81

—

(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis

1.29

0.23

3.4

2.6

0.00

g/l

—

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

1.28

0.23

2.7

3.3

4.71

4.41

pmol/l

—

(3023939) Sjogrens syndrome-A extractable nuclear Ab [Units/volume] in Serum

1.23

0.22

1.0

1.2

—

34.72

—

(3029634) Reagin Ab [Titer] in Serum by VDRL

0.00

0.21

0.0

1.3

—

(37020957) Sapovirus genogroups I+II+IV+V RNA [Presence] in Stool by NAA with probe detection

0.00

0.21

0.0

1.5

—

(3011363) Streptococcus pneumoniae Ag [Presence] in Urine

0.00

0.21

0.0

1.1

—

(40760543) Extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.0

—

(42869457) Rotavirus RNA [Identifier] in Stool by NAA with probe detection

0.00

0.21

0.0

1.5

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

0.21

0.0

1.2

—

(3027953) Aldolase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.21

0.0

1.5

—

9.49

—

(3051611) Lipemic interference index of Serum or Plasma

0.00

0.21

0.0

3.2

—

10.20

—

(3047826) Mullerian inhibiting substance [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.1

—

5.08

—

(3045683) HLA typing for celiac disease panel - Blood or Tissue

0.00

0.21

0.0

1.0

—

(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot

0.00

0.21

0.0

1.1

—

(3045142) Bone marrow Pathology biopsy report

0.00

0.21

0.0

1.3

—

(4035726) Immunohistochemistry procedure

117

1.22

0.21

1.8

1.3

—

(3035350) Ketones [Presence] in Urine by Test strip

712

1.11

0.21

5.0

4.2

0.00

11.52

estimate

0.50

141

(3001405) CD3+CD8+ (T8 suppressor) cells [#/volume] in Blood

0.00

0.21

0.0

2.4

—

671.29

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.21

0.0

1.2

—

(3009595) Pneumocystis jirovecii DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.5

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

0.21

0.0

1.8

—

(3003694) ABO and Rh group [Type] in Blood

383

0.89

0.21

1.3

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

222

1.15

0.20

3.2

4.45

3.09

e6/l

0.22

(3009261) Glucose [Presence] in Urine by Test strip

723

1.10

0.20

4.9

4.2

0.35

0.00

estimate

0.48

133

(3047007) Chlamydophila sp Ab [Presence] in Serum

0.00

0.20

0.0

1.1

—

(40768793) Breast Pathology biopsy report

1.23

0.20

1.2

1.4

—

(3019150) Specific gravity of Urine by Refractometry

310

1.12

0.19

3.9

4.0

1.02

kg/l

0.19

198

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.25

0.19

3.9

7.7

22.81

25.03

mmol/l

—

(3021601) Nitrite [Presence] in Urine by Test strip

707

1.09

0.17

5.1

4.1

0.00

estimate

-0.00

140

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.14

0.17

1.1

1.5

—

(3020891) Body temperature

1.15

0.16

2.3

3.9

37.03

36.93

°c

—

(3027273) Bicarbonate [Moles/volume] in Venous blood

1.12

0.16

4.6

2.9

26.58

25.11

mmol/l

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

1.12

0.15

5.4

3.6

46.50

47.74

—

(3021589) Normoblasts [#/volume] in Blood

604

1.07

0.13

15.6

11.4

0.00

e9/l

0.27

479

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

259

1.10

0.12

4.5

3.4

23.14

195.54

ng/l

0.98

209

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

231

1.10

0.11

1.6

1.4

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

1.11

0.10

1.6

1.2

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.16

0.09

2.0

1.8

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

1.04

0.09

1.8

2.5

—

(3000492) Spirometry study

117

1.12

0.08

1.4

1.5

—

(3000330) Specific gravity of Urine by Test strip

1.07

0.07

5.0

4.8

1.02

ratio

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

228

1.06

0.05

1.4

1.6

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

191

0.93

0.05

3.1

3.0

0.67

0.77

ug/l

0.39

125

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

239

1.06

0.04

3.0

3.1

0.98

1.08

e6/l

0.07

113

(3000494) Fungus identified in Specimen by Culture

180

1.06

0.04

1.4

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

780

0.97

0.02

3.2

3.0

—

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

138

1372

1.06

0.02

17.8

11.8

25.22

24.86

u/l

0.13

133

1335

(3000991) Gas panel - Venous blood

114

1.06

0.01

7.8

8.6

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.04

0.00

2.3

1.9

—

(4010399) Spirometry for bronchospasm with prolonged evaluation after bronchodilator

111

0.99

0.00

1.4

—

(21494755) Public health laboratory ask at order entry panel

103

0.97

0.00

1.0

1.3

—

(3018418) pH of Serum or Plasma

437

1.01

0.00

8.0

3.7

7.39

7.40

0.52

305

(3015736) pH of Urine

577

1.01

0.00

4.3

3.8

6.22

6.24

0.03

307

(3037692) Legionella sp identified in Specimen by Organism specific culture

0.00

0.0

1.3

—

(3018301) Testosterone Free [Moles/volume] in Serum or Plasma

0.00

0.0

1.3

—

166.65

—

(40764127) Haemophilus influenzae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.0

—

(3007847) Interleukin 2 Receptor Soluble [Units/volume] in Serum or Plasma

0.00

0.0

3.5

—

1157.50

—

(3005082) Progesterone [Moles/volume] in Serum or Plasma

0.00

0.0

1.0

—

41.90

—

(3026470) Cobalt [Mass/volume] in Blood

0.00

0.0

2.5

—

3.00

—

(3005791) Eosinophil cationic protein (ECP) [Mass/volume] in Serum

0.00

0.0

3.2

—

18.47

—

(3015024) Glucose [Moles/volume] in Serum or Plasma --1 hour post dose glucose

0.00

0.0

2.3

—

7.60

—

(40765096) Chromosome analysis panel by Banding

0.00

0.0

1.2

—

(3026048) Bordetella pertussis IgG Ab [Units/volume] in Serum

0.00

0.0

1.2

—

39.23

—

(3015183) Erythrocyte sedimentation rate [Velocity] in Red Blood Cells

0.00

0.0

1.0

—

11.00

—

(3043410) Blood group antigens tested for on Red Blood Cells

0.00

0.0

1.3

—

(3003245) Complement C1 esterase inhibitor [Mass/volume] in Serum or Plasma

0.00

0.0

1.3

—

0.32

—

(3016244) Insulin [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

2.0

—

12.76

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.00

-0.00

0.0

1.0

—

(40768443) Skin Pathology biopsy report

0.97

-0.00

1.3

1.2

—

(3035880) pH of Pleural fluid

0.00

-0.00

0.0

1.4

—

7.46

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.89

-0.00

4.6

1.6

—

(4211845) Urine protein measurement

0.00

-0.00

0.0

1.6

—

(3016436) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma

0.00

-0.00

0.0

1.4

—

206.71

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

7.4

—

1138.20

—

(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.3

—

62.14

—

(3008152) Bicarbonate [Moles/volume] in Arterial blood

0.92

-0.00

4.8

7.2

23.29

24.98

mmol/l

—

(3013637) Mi-2 Ab [Presence] in Serum

0.00

-0.00

0.0

1.0

—

(42529582) MDA5 Ab [Presence] in Serum by Line blot

0.00

-0.00

0.0

1.0

—

(42529598) SUMO-activating enzyme subunit 1 Ab [Presence] in Serum by Line blot

0.00

-0.00

0.0

1.0

—

(42529528) Centromere protein B Ab [Units/volume] in Serum by Line blot

0.00

-0.00

0.0

1.0

—

(3051651) Icteric interference index of Serum or Plasma

0.00

-0.00

0.0

4.4

—

0.60

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

0.91

-0.00

2.2

1.8

—

(3039429) Cortisol [Moles/volume] in Saliva (oral fluid)

0.00

-0.00

0.0

2.4

—

23.82

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.94

-0.00

1.8

—

(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.6

—

(3022058) Hepatitis B virus DNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

-0.00

0.0

1.6

—

(21494815) CD4 cells/Lymphocytes in Specimen

0.00

-0.00

0.0

1.2

—

42.72

—

(42528593) TIF1-gamma Ab [Presence] in Serum by Line blot

0.00

-0.00

0.0

1.0

—

(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay

0.00

-0.00

0.0

3.2

—

85.60

—

(36306090) Helicobacter pylori [Presence] in Tissue by Organism specific culture

0.00

-0.00

0.0

1.1

—

(3045066) Thymidine kinase [Enzymatic activity/volume] in Serum

0.00

-0.00

0.0

1.4

—

32.94

—

(3008536) Aspergillus sp Ab [Presence] in Serum

0.00

-0.00

0.0

1.2

—

(3011436) Histone Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.2

—

(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.1

—

(3024666) Lithium [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

8.9

—

0.71

—

(3040363) Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.0

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

-0.00

0.0

1.0

—

(3029023) Hepatitis E virus IgG Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.0

—

(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.3

—

(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.6

—

(21493690) Lymphocyte T-cell and B-cell and Natural killer subsets panel - Blood

0.00

-0.00

0.0

3.0

—

(3002222) Hepatitis E virus IgM Ab [Presence] in Serum

0.00

-0.00

0.0

1.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint L12_APOCRINESWEAT and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have L12_APOCRINESWEAT.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: L12_APOCRINESWEAT – Apocrine sweat disorders, other sweat gland disorders

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

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Apocrine sweat disorders, other sweat gland disorders

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints