esophageal disease: A non-neoplastic or neoplastic disorder that affects the esophagus. Representative examples of non-neoplastic disorders include esophagitis and esophageal ulcer. Representative examples of neoplastic disorders include carcinomas, lymphomas, and melanomas.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
209 |
4. Check minimum number of eventsNone |
209 |
5. Include endpointsNone |
209 |
6. Filter based on genotype QC (FinnGen only) |
187 |
Control definitions (FinnGen only)
- Control exclude
- K11_OESSTODUO
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- K22
- Name in latin
- Perforatio oesophagi
Similar endpoints
↥List of similar endpoints to
Perforation of oesophagus
based on the number of shared cases.
Similar with more cases:
- Diseases of oesophagus, stomach and duodenum
- Gastrointestinal diseases
- Any operation in hilmo
- Any prescribed medicine buy
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1531 | 568 | 942 |
| Only index persons | 1177 | 448 | 729 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.03 |
| Only index persons | 0.02 | 0.02 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 65.20 | 69.78 | 62.30 |
| Only index persons | 64.77 | 68.22 | 62.65 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 187 | 73 | 114 |
| Unadjusted period prevalence (%) | 0.04 | 0.03 | 0.05 |
| Median age at first event (years) | 64.31 | 63.98 | 64.52 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 191
- Matched controls
- 1910
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K22.3
ICD-10 Finland
Perforation of oesophagus
+∞
259.6
185
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
30.4
122.7
151
211
JCF12
NOMESCO Finland
Endoscopic insertion of prosthetic tube into oesphagus
340.9
70.4
67
*
UJD02
NOMESCO Finland
Gastroscopy
34.5
61.8
41
15
JC2AB
NOMESCO Finland
Oesophagus X-ray examination with contrast
721.9
56.7
53
*
R13
ICD-10 Finland
Dysphagia
14.0
52.8
56
55
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
90.8
49.1
53
8
K22.2
ICD-10 Finland
Oesophageal obstruction
+∞
48.0
44
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
12.7
47.4
53
56
JDW98
NOMESCO Finland
Other transluminal endoscopic operation on stomach or duodenum
206.2
47.2
47
*
JCA55
NOMESCO Finland
Endoscopic dilatation of oesophagus
110.1
40.7
43
5
UJC12
NOMESCO Finland
Flexible oesophagoscopy
251.2
40.5
40
*
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
16.8
40.2
36
26
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
6.6
37.2
89
222
R4190
NOMESCO Finland
Nutritional therapy
14.6
34.2
33
27
JDB10
NOMESCO Finland
Percutaneous gastrostomy
65.0
32.7
37
7
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
13.0
29.2
30
27
JCE00
NOMESCO Finland
Suture of oesophagus
+∞
27.8
26
*
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
31.3
27.4
36
14
UGC12
NOMESCO Finland
Flexible bronchoscopy
7.3
26.1
44
75
A02BC05
ATC
esomeprazole; systemic
4.8
25.5
116
467
JCA08
NOMESCO Finland
Endoscopic removal of foreign body from oesophagus
95.4
23.3
25
*
WX872
NOMESCO Finland
Intensive care
7.7
23.1
36
56
K22.1
ICD-10 Finland
Ulcer of oesophagus
+∞
22.3
21
*
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
7.2
22.2
37
62
TJD20
NOMESCO Finland
Change of gastrostomy tube
123.6
21.0
22
*
GD1AD
NOMESCO Finland
Thorax CT examination
6.7
19.8
35
62
WX892
NOMESCO Finland
Monitored bed care
6.2
18.8
36
69
JCB00
NOMESCO Finland
Oesophagostomy
+∞
18.0
17
*
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
8.0
17.9
26
37
K20
ICD-10 Finland
Oesophagitis
185.5
16.8
17
*
WX408
NOMESCO Finland
General anesthesy, balanced
3.7
16.7
79
307
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.8
16.5
133
723
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.8
16.4
69
248
WX302
NOMESCO Finland
Thoracal epidural anesthesy
7.2
16.3
26
41
JDB00
NOMESCO Finland
Gastrostomy
+∞
15.8
15
*
K22.0
ICD-10 Finland
Achalasia of cardia
+∞
15.8
15
*
UJC02
NOMESCO Finland
Rigid oesophagoscopy
41.9
15.7
19
5
T18.1
ICD-10 Finland
Foreign body in oesophagus
49.4
15.4
18
*
ZXD05
NOMESCO Finland
Urgent procedure
3.4
15.2
85
364
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
5.5
14.9
32
68
WX404
NOMESCO Finland
Intravenous generell anesthesy
3.7
14.7
62
221
ZXE00
NOMESCO Finland
One hour or less
3.2
14.1
101
497
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
4.2
14.1
44
127
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
3.2
13.9
85
380
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
5.4
13.8
30
64
GD5AD
NOMESCO Finland
Thorax and upper abdomen combined CT examination of
20.1
13.7
20
11
WX402
NOMESCO Finland
General anaesthesia
3.4
13.3
65
253
ZXE30
NOMESCO Finland
More than five and less than seven hours
6.6
12.9
22
37
TPH07
NOMESCO Finland
Cathetrisation of artery
4.1
12.8
40
115
JCC10
NOMESCO Finland
Transthoracic partial oesophagectomy without interposition
75.0
12.8
14
*
J01MA12
ATC
levofloxacin; systemic
3.4
12.7
58
216
GAA10
NOMESCO Finland
Intercostal insertion of pleural drainage tube
17.4
12.4
19
12
JN4BD
NOMESCO Finland
Extensive body CT
3.9
12.4
43
133
JN4AD
NOMESCO Finland
Body CT examination
3.8
12.2
45
145
JAH00
NOMESCO Finland
Laparotomy
10.0
12.2
24
27
N03AX16
ATC
[U] pregabalin
3.2
12.1
61
241
GD5BD
NOMESCO Finland
Thorax and upper abdomen combined extensive CT examination of
13.8
11.9
20
16
TPH04
NOMESCO Finland
Cathetrisation of vein
3.1
11.8
66
276
A02BC02
ATC
pantoprazole; systemic
3.5
11.8
151
995
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
3.5
11.8
50
177
GA4AT
NOMESCO Finland
Cathetrisation of pleural cavity with ultrasound guidance
18.5
11.4
17
10
A03FA01
ATC
metoclopramide; systemic, rectal
3.1
11.4
62
255
RD210, ,
NOMESCO Finland
21.7
11.3
16
8
TPH30
NOMESCO Finland
Insertion of central venous catheter through periferal vein
16.8
11.1
17
11
J01MA14
ATC
moxifloxacin; systemic
4.2
10.8
32
88
Z98.8
ICD-10 Finland
Other specified postsurgical states
63.6
10.7
12
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.9
10.7
75
353
A02BC03
ATC
lansoprazole; oral
2.9
10.7
68
304
K22.4
ICD-10 Finland
Dyskinesia of oesophagus
+∞
10.5
10
*
D84
ICPC
Oesophagus disease
+∞
10.5
10
*
JDB01
NOMESCO Finland
Laparoscopic gastrostomy
+∞
10.5
10
*
TJF00
NOMESCO Finland
Insertion of jejunal tube
+∞
10.5
10
*
K22.8
ICD-10 Finland
Other specified diseases of oesophagus
+∞
10.5
10
*
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
4.7
10.5
26
62
Z3226
NOMESCO Finland
Physiotherapist
3.1
10.2
54
217
JN3AD
NOMESCO Finland
Abdominal CT examination
3.5
10.2
40
134
A02BA04
ATC
nizatidine; systemic
4.8
10.1
24
55
C15.5
ICD-10 Finland
Malignant neoplasm: Lower third of oesophagus
21.4
10.0
14
7
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
9.9
9.8
19
21
GAB10
NOMESCO Finland
Antero- or postero-lateral thoracotomy
58.0
9.8
11
*
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
3.8
9.7
32
95
N05CF01
ATC
zopiclone; oral
2.6
9.5
82
424
J45.9
ICD-10 Finland
Asthma, unspecified
3.1
9.5
49
193
JC2KB
NOMESCO Finland
Functional X-ray examination of swallowing
23.1
9.5
13
6
JCF00
NOMESCO Finland
Insertion of prosthetic tube into oesphagus
+∞
9.4
9
*
JCE96
NOMESCO Finland
Other reconstruction of oesophagus
+∞
9.4
9
*
ZXE20
NOMESCO Finland
More than three and less than five hours
3.3
9.4
42
152
K92.0
ICD-10 Finland
Haematemesis
14.7
9.4
15
11
C15.9
ICD-10 Finland
Malignant neoplasm: Oesophagus, unspecified
38.7
9.1
11
*
GD1CD
NOMESCO Finland
Thorax extensive CT-examination
19.8
9.1
13
7
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.2
9.0
40
144
R10.1
ICD-10 Finland
Pain localized to upper abdomen
3.1
8.9
43
163
WX002
NOMESCO Finland
Sedation and analgesia
2.9
8.8
52
220
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
5.0
8.6
19
41
JCC12
NOMESCO Finland
Thoracoscopic or laparoscopic partial oesophagectomy
94.0
8.5
9
*
K22.9
ICD-10 Finland
Disease of oesophagus, unspecified
94.0
8.5
9
*
JCD03
NOMESCO Finland
Subcutaneous anastomosis of oesophagus with interposition of intestine
+∞
8.4
8
*
JCA98
NOMESCO Finland
Other local endoscopic operation on oesophagus
+∞
8.4
8
*
JCC96
NOMESCO Finland
Other partial oesophagectomy
+∞
8.4
8
*
5304A
ICD-9 Finland
Diseases of oesophagus, Perforation of oesophagus
+∞
8.4
8
*
JBC01
NOMESCO Finland
Laparoscopic gastro-oesophageal antireflux operation
+∞
8.4
8
*
R4110
NOMESCO Finland
Physiotherapy
2.5
8.3
71
361
J38.0
ICD-10 Finland
Paralysis of vocal cords and larynx
10.7
8.2
15
15
GBB00
NOMESCO Finland
Tracheostomy
18.2
8.2
12
7
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
11.5
7.9
14
13
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
3.3
7.9
33
114
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
4.9
7.8
18
40
UJC01
NOMESCO Finland
Scopy of lower throat
12.6
7.7
13
11
T81.8
ICD-10 Finland
Other complications of procedures, not elsewhere classified
10.7
7.7
14
14
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.8
7.6
46
196
Z43.1
ICD-10 Finland
Attention to gastrostomy
83.2
7.5
8
*
J98.5
ICD-10 Finland
Diseases of mediastinum, not elsewhere classified
83.2
7.5
8
*
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
6.7
7.4
18
29
A07AA02
ATC
nystatin; oral
4.3
7.4
20
51
1310
FHL
Esophagogastroscopy
+∞
7.3
7
*
K22.6
ICD-10 Finland
Gastro-oesophageal laceration-haemorrhage syndrome
+∞
7.3
7
*
JBC00
NOMESCO Finland
Gastro-oesophageal antireflux operation
+∞
7.3
7
*
K22.5
ICD-10 Finland
Diverticulum of oesophagus, acquired
+∞
7.3
7
*
R03AK06
ATC
salmeterol and fluticasone; inhalant
3.0
7.3
37
143
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
3.9
7.3
22
61
T36
ICD-10 Finland
Poisoning by systemic antibiotics
8.5
7.3
15
19
WX704
NOMESCO Finland
Intubation
3.8
7.2
23
66
T05
ICPC
Feeding problem of adult
21.0
7.2
10
5
ZXE40
NOMESCO Finland
More than seven and less than nine hours
12.7
7.2
12
10
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
7.5
7.2
16
23
N02AA05
ATC
oxycodone; systemic
2.5
6.8
51
241
N05BE01
ATC
buspirone; oral
9.2
6.7
13
15
A28
ICPC
Limited function/disability NOS
2.5
6.6
49
230
ZXD10
NOMESCO Finland
Scheduled procedure
2.2
6.5
81
477
JAH01
NOMESCO Finland
Laparoscopy
6.4
6.5
16
27
N05AH03
ATC
olanzapine; systemic
4.1
6.4
18
47
N05AH04
ATC
quetiapine; oral
2.6
6.3
42
187
J86.09
ICD-10 Finland
Pyothorax with fistula
+∞
6.3
6
*
JCW96
NOMESCO Finland
Other operations on oesophagus
+∞
6.3
6
*
JDA55
NOMESCO Finland
Endoscopic dilatation of stomach, pylorus or anastomosis of stomach
+∞
6.3
6
*
J85.3
ICD-10 Finland
Abscess of mediastinum
+∞
6.3
6
*
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
8.1
6.2
13
17
UDQ12
NOMESCO Finland
Flexible laryngoscopy
4.4
6.2
16
39
X59
ICD-10 Finland
Exposure to unspecified factor
2.5
6.2
46
216
F10.25
ICD-10 Finland
Alcohol dependence continuous use
13.1
6.2
10
8
Z01.8
ICD-10 Finland
Other specified special examinations
2.4
6.1
48
231
F32.9
ICD-10 Finland
Depressive episode, unspecified
3.2
6.1
25
85
N06AX11
ATC
mirtazapine; oral
2.2
6.0
70
399
UJF32
NOMESCO Finland
Coloscopy
2.3
6.0
56
291
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
57
157
4.75
19.83
5.4
6.7
7.65
10.73
mmol/l
2.66
57
146
44
123
4.35
14.71
2.0
1.6
—
—
—
0
0
128
727
3.31
13.83
10.2
4.8
31.71
35.49
g/l
8.29
123
682
65
252
3.39
13.41
19.4
6.8
104.91
104.15
mmol/l
0.51
65
252
48
154
3.83
13.20
3.5
2.2
0.17
0.21
g/l
3.19
48
144
68
286
3.14
12.10
2.5
2.1
—
—
—
0
0
51
184
3.42
11.64
23.6
7.7
116.67
119.32
g/l
0.31
51
179
82
397
2.87
11.18
6.5
2.6
—
—
—
0
0
55
215
3.19
10.96
21.9
7.0
2.04
0.83
mmol/l
1.47
50
177
32
91
4.02
10.29
17.3
9.2
14.67
15.63
%
0.87
32
85
54
218
3.06
10.11
22.5
6.9
5.44
5.08
kpa
1.68
54
208
54
218
3.06
10.11
22.5
6.9
12.06
11.85
kpa
0.11
54
208
132
848
2.80
9.96
15.6
7.1
1.20
1.21
mmol/l
1.19
119
720
121
766
2.58
9.04
14.8
6.7
1.19
1.21
mmol/l
2.59
116
703
50
205
2.95
9.02
2.2
2.0
—
—
—
0
0
52
218
2.90
9.01
2.2
1.9
—
—
—
0
0
67
331
2.58
8.37
4.8
3.6
97.22
486.19
ng/l
1.62
54
271
117
768
2.35
7.52
6.9
2.8
—
—
estimate
—
0
0
77
423
2.37
7.50
2.9
2.0
2.91
2.99
mg/l
0.12
66
364
35
138
2.88
6.66
5.7
2.8
22.80
33.33
u/l
2.25
30
109
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
20
56
3.87
6.51
3.3
2.3
0.25
0.36
iu/ml
—
10
25
30
112
2.99
6.28
25.5
7.5
26.51
24.25
mmol/l
2.34
30
112
28
106
2.92
5.71
2.3
1.8
—
—
—
0
0
54
282
2.28
5.70
2.5
1.7
1120.05
1314.61
nmol/l
0.84
44
211
40
183
2.50
5.66
2.7
3.7
6.12
5.63
kpa
1.56
40
178
27
102
2.92
5.52
3.1
3.9
25.56
24.26
mmol/l
0.87
27
102
105
715
2.04
5.50
2.6
2.0
89.80
95.40
pmol/l
0.64
65
385
124
919
2.00
4.87
14.4
10.5
4.72
4.16
e9/l
1.56
109
814
14
31
4.79
4.66
1.4
1.5
—
—
—
0
0
84
555
1.92
4.56
3.4
3.4
2.30
2.35
mmol/l
2.77
77
506
11
19
6.07
4.51
1.4
1.5
—
—
—
0
0
11
19
6.07
4.51
1.4
1.5
—
—
—
0
0
75
493
1.86
4.03
4.0
3.3
0.25
0.43
e6/l
0.88
64
376
98
701
1.82
3.99
3.4
2.8
186.50
166.84
ug/l
0.15
91
642
14
44
3.35
3.86
2.1
1.6
—
—
—
0
0
14
44
3.35
3.86
1.4
1.5
—
—
—
0
0
75
505
1.80
3.66
1.8
1.7
21.27
20.22
nmol/l
0.25
66
417
8
13
6.37
3.54
3.8
2.5
—
—
—
0
0
13
42
3.25
3.44
1.7
1.2
—
—
—
0
0
87
624
1.72
3.34
4.0
3.4
—
—
—
0
0
25
117
2.31
3.34
11.4
6.8
25.42
24.43
mmol/l
0.72
25
109
25
120
2.25
3.15
2.7
2.9
125.16
128.63
g/l
0.28
25
115
5
5
10.22
2.99
1.4
1.0
—
—
—
0
0
22
103
2.28
2.94
4.2
3.7
3.89
2.38
mmol/l
1.10
17
76
54
353
1.74
2.81
2.0
1.7
2.20
1.49
mg/l
0.49
45
284
9
23
4.05
2.81
3.4
4.7
—
—
—
0
0
47
298
1.77
2.71
3.6
3.1
1.51
0.86
e6/l
0.54
27
165
30
165
1.97
2.68
1.8
3.5
62.37
66.34
g/l
1.55
30
152
14
55
2.67
2.68
4.6
2.3
1.40
1.68
mg/l
0.61
14
45
44
275
1.78
2.66
3.6
3.2
2.32
1.04
e6/l
0.58
23
146
14
57
2.57
2.51
2.7
1.7
—
—
—
0
0
14
59
2.48
2.35
3.4
2.1
—
—
—
0
0
90
696
1.55
2.33
4.3
3.9
22.06
49.63
ng/l
2.82
77
530
50
342
1.63
2.16
3.9
3.0
2.47
2.45
mmol/l
0.31
43
313
6
15
4.09
2.05
1.0
1.3
—
—
—
0
0
15
70
2.24
2.04
2.9
2.3
—
—
—
0
0
19
98
2.04
2.03
1.9
1.4
—
—
—
0
0
13
58
2.33
1.95
1.7
1.7
—
—
—
0
0
77
599
1.48
1.84
2.7
3.4
2166.67
1499.49
ng/l
0.32
72
506
148
1615
0.63
1.82
5.8
6.1
2.49
2.62
mmol/l
1.06
136
1477
9
36
2.57
1.76
2.0
1.9
—
—
—
0
0
140
1539
0.66
1.67
6.3
6.7
39.19
39.87
mmol/mol
0.50
135
1434
145
1580
0.66
1.60
5.2
5.3
4.36
4.51
mmol/l
0.97
134
1448
144
1571
0.66
1.60
5.0
5.2
1.47
1.42
mmol/l
0.64
129
1429
22
131
1.77
1.57
3.4
2.5
84.40
62.38
ml/min/173m2
—
5
48
6
21
2.92
1.52
2.0
1.8
—
—
—
0
0
11
52
2.18
1.47
1.5
1.2
—
—
—
0
0
29
191
1.61
1.45
5.7
3.3
—
—
—
0
0
6
22
2.78
1.44
2.0
1.8
—
—
—
0
0
6
22
2.78
1.44
2.0
1.8
—
—
—
0
0
12
61
2.03
1.36
1.2
1.4
11.78
4.43
iu/ml
—
6
13
6
134
0.43
1.34
1.2
2.2
3.45
3.60
ratio
—
6
110
131
1164
1.40
1.34
3.7
3.9
14.94
14.98
pmol/l
0.05
124
1044
101
869
1.34
1.22
2.9
2.7
—
—
—
0
0
8
39
2.10
1.17
1.1
1.2
21.14
30.43
u/l
—
8
33
31
221
1.48
1.12
4.0
5.9
216.00
239.00
u/l
1.23
31
209
7
31
2.30
1.11
1.0
1.6
—
—
—
0
0
5
21
2.42
1.09
2.2
1.8
—
—
—
0
0
14
82
1.76
1.08
1.1
2.3
2.72
3.05
g/l
0.89
14
75
5
22
2.31
1.04
2.2
1.8
—
—
—
0
0
5
22
2.31
1.04
2.2
1.8
—
—
—
0
0
7
34
2.10
1.04
1.0
1.3
—
39.71
—
0
8
63
752
0.76
1.00
5.4
5.6
2.01
2.39
ug/l
0.34
55
680
14
85
1.70
0.97
1.1
2.3
4.17
4.39
g/l
0.33
14
78
14
85
1.70
0.97
1.1
2.3
3.39
3.51
g/l
0.22
14
78
14
85
1.70
0.97
1.1
2.3
7.39
7.37
g/l
0.02
14
78
6
28
2.18
0.92
1.0
1.4
—
—
—
0
0
6
29
2.10
0.90
1.2
1.2
—
—
—
0
0
22
158
1.44
0.79
1.6
2.7
0.45
0.19
e6/l
0.63
22
150
166
1580
1.39
0.77
46.4
16.2
38.90
24.86
mg/l
5.09
159
1295
9
54
1.70
0.76
1.7
1.6
—
—
—
0
0
7
38
1.87
0.74
1.1
1.6
275.86
334.12
mu/l
—
7
38
5
25
2.03
0.73
2.8
2.1
—
—
—
0
0
19
135
1.45
0.72
1.7
1.4
—
—
—
0
0
5
28
1.81
0.66
2.8
2.0
—
—
—
0
0
51
598
0.80
0.66
3.5
4.2
10.19
9.75
mg/mmol
0.02
34
391
60
691
0.81
0.66
1.9
2.0
1.39
1.35
mmol/l
0.13
51
565
5
29
1.74
0.64
2.0
1.6
—
—
—
0
0
10
63
1.62
0.63
1.1
2.7
0.00
0.00
g/l
—
10
56
11
72
1.56
0.60
1.1
2.4
8.25
10.53
g/l
2.10
11
64
52
595
0.83
0.52
3.6
4.8
18.61
22.22
%
1.28
28
306
38
447
0.81
0.50
3.2
3.2
0.67
0.73
ug/l
0.20
32
301
7
47
1.51
0.48
1.7
1.5
—
—
—
0
0
12
85
1.44
0.48
1.2
1.2
1045.64
223.81
u/ml
0.45
12
79
7
50
1.41
0.45
1.4
1.9
—
—
—
0
0
7
50
1.41
0.45
2.3
1.4
—
—
—
0
0
144
1501
0.83
0.45
4.7
4.4
1.21
1.30
mmol/l
1.08
130
1362
18
227
0.77
0.43
1.3
1.4
15.11
17.47
u/ml
—
8
94
12
160
0.73
0.41
1.2
1.5
—
—
—
0
0
0
18
0.00
0.40
0.0
4.2
—
1531.33
—
0
18
5
36
1.40
0.38
2.0
1.6
—
—
—
0
0
6
41
1.48
0.36
1.8
1.5
—
—
—
0
0
43
382
1.16
0.33
3.6
3.9
1.02
1.02
kg/l
0.20
35
244
95
892
1.13
0.33
3.8
3.8
0.00
0.00
estimate
-0.00
22
177
94
883
1.13
0.32
3.9
3.8
0.00
8.20
estimate
0.50
23
198
7
52
1.36
0.31
1.3
1.2
0.25
0.25
g/l
—
7
52
93
875
1.12
0.31
3.9
3.8
0.00
0.00
estimate
-0.00
23
192
7
54
1.31
0.31
1.3
1.2
1.05
1.20
g/l
—
7
54
150
1542
0.87
0.28
5.3
5.3
5.85
6.05
mmol/l
1.53
144
1396
8
65
1.24
0.27
1.1
2.1
27.96
36.93
u/l
—
8
55
9
72
1.26
0.26
1.2
1.0
—
—
—
0
0
14
114
1.25
0.26
2.9
3.8
93.79
86.67
ng/l
0.11
14
96
18
209
0.85
0.22
1.4
1.5
—
—
—
0
0
5
42
1.20
0.21
1.2
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
3.9
—
1.08
—
0
12
0
13
0.00
0.21
0.0
1.2
—
9.89
—
0
13
0
13
0.00
0.21
0.0
2.4
—
13.82
—
0
13
0
13
0.00
0.21
0.0
1.8
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.6
—
3.00
—
0
7
8
98
0.81
0.14
1.3
2.0
—
—
—
0
0
51
484
1.07
0.13
3.1
3.4
0.09
0.00
estimate
0.48
22
152
5
44
1.14
0.10
1.6
2.0
—
—
—
0
0
120
1179
1.05
0.08
5.0
4.2
17.42
12.53
mm/h
1.91
115
1095
147
1451
1.06
0.08
5.0
4.8
1.87
2.04
mu/l
1.00
137
1311
6
73
0.82
0.07
1.2
1.3
—
—
—
0
0
9
103
0.87
0.06
1.4
2.3
—
—
—
0
0
19
199
0.95
0.03
9.3
7.5
—
—
—
0
0
45
460
0.97
0.03
3.2
3.2
325.38
355.45
umol/l
1.08
40
406
68
674
1.01
0.00
3.7
3.7
0.09
0.02
estimate
0.56
22
163
50
504
0.99
0.00
3.8
3.8
0.00
0.01
estimate
0.50
22
173
0
6
0.00
-0.00
0.0
1.0
—
0.26
—
0
6
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
1344.80
—
0
5
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
13.25
—
0
8
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
49
1.02
-0.00
1.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
5
49
1.02
-0.00
1.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint K11_PERFOES and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_PERFOES | 2.851 [2.1, 3.87] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.097 |
During the follow-up period (1.1.1998 — 31.12.2019), 161 out of 359 females with K11_PERFOES died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_PERFOES | 3.71 [2.7, 5.09] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.097 |
During the follow-up period (1.1.1998 — 31.12.2019), 293 out of 605 males with K11_PERFOES died.
Mortality risk
Mortality risk for people of age
years, who have K11_PERFOES.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.263% | 0.671% |
| 5 | 1.521% | 4.559% |
| 10 | 3.626% | 11.643% |
| 15 | 7.001% | 21.535% |
| 20 | 12.095% | 35.304% |
Relationships between endpoints
↥Index endpoint: K11_PERFOES – Perforation of oesophagus
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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