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Ulcer of oesophagus, drug-induced

Endpoint Browser PheWeb

K11_OESULC_ADVERSE

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ATC codes for adverse effects of Drugs — ANY
  • Hospital discharge: ICD-10 — K22.1#

1 out of 7 registries used, show all original rules.

187

4. Check minimum number of events

None

187

5. Include endpoints

None

187

6. Filter based on genotype QC (FinnGen only)

169

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF5
Parent code in ICD-10
K22
Name in latin
Ulcus oesophagi

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded (not available in FinRegistry).

-FinnGen-

Key figures

All Female Male
Number of individuals 169 50 119
Unadjusted period prevalence (%) 0.04 0.02 0.05
Median age at first event (years) 57.62 55.56 58.48

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
173
Matched controls
1730
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K22.1
ICD-10 Finland
Ulcer of oesophagus
+∞
220.5
173
23
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
13.7
65.7
83
109
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
8.9
43.3
125
391
A02BC01
ATC
omeprazole; systemic
8.2
42.0
117
351
A02BC03
ATC
lansoprazole; oral
7.6
38.9
116
365
UJD02
NOMESCO Finland
Gastroscopy
11.2
38.0
46
54
K22.7
ICD-10 Finland
Barrett oesophagus
38.8
25.7
32
10
A02BA04
ATC
nizatidine; systemic
6.8
22.4
41
76
JBC01
NOMESCO Finland
Laparoscopic gastro-oesophageal antireflux operation
22.6
18.9
27
14
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
5.7
18.1
39
84
A02BA02
ATC
ranitidine; systemic
3.7
15.2
73
288
A02BA03
ATC
famotidine; systemic
6.6
14.4
25
43
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
4.9
13.4
33
79
A03FA02
ATC
cisapride; oral, rectal
4.6
11.8
31
78
6241
FHL
Fund application (Nissen)
34.9
10.5
13
*
XJC10
NOMESCO Finland
Oesophageal pH monitoring
+∞
9.5
9
*
-, ,
ICD-10 Finland
12.5
8.8
15
13
5301B
ICD-9 Finland
Diseases of oesophagus, Oesophagitis[BARRETT'S OESOPHAGUS]
94.5
8.5
9
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.5
7.9
71
373
XJC02
NOMESCO Finland
Mesurement of oesophageal pressure and pressure profile of lower oesophageal sphincter
47.1
7.8
9
*
N06AA09
ATC
amitriptyline; systemic
3.6
7.5
26
80
5308A
ICD-9 Finland
Diseases of oesophagus, Other specified disorders of oesophagus[HERNIA HIATUS OESOPHAGI (""""SLIDING HERNIA"""")]
31.5
7.2
9
*
A02BC05
ATC
esomeprazole; systemic
2.3
6.8
83
493
JBC00
NOMESCO Finland
Gastro-oesophageal antireflux operation
23.6
6.7
9
*
J01DA01
ATC
[U] cefalexin
2.4
6.5
117
813
ZXE10
NOMESCO Finland
More than one and less than three hours
2.2
6.2
74
432
N05CF01
ATC
zopiclone; oral
2.2
6.0
74
435

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
42
183
2.71
6.69
1.9
1.3
—
—
—
0
0
61
321
2.39
6.54
6.4
4.7
1.02
1.02
kg/l
0.28
47
219
80
478
2.25
6.33
5.5
4.6
7.40
7.40
ph
0.71
64
350
56
317
2.13
4.84
4.8
4.3
27.29
371.48
ng/l
2.20
49
279
69
424
2.04
4.79
2.7
2.2
3.00
2.93
mg/l
0.08
62
365
40
211
2.17
4.07
6.9
6.4
7.42
7.41
ph
0.39
31
130
73
480
1.90
4.02
1.9
1.9
17.22
20.65
nmol/l
1.28
65
390
96
691
1.87
3.98
6.9
5.0
33.49
34.29
g/l
0.60
91
649
81
567
1.81
3.55
4.6
4.0
6.13
6.21
ph
0.35
47
319
82
578
1.80
3.50
3.9
3.0
151.02
166.62
ug/l
0.30
76
525
38
209
2.05
3.45
7.2
6.5
2.38
0.87
mmol/l
1.96
31
175
50
316
1.82
2.99
5.2
4.4
—
0.29
—
0
7
96
731
1.70
2.97
5.3
4.4
0.00
0.00
estimate
-0.00
16
176
97
741
1.70
2.96
5.4
4.4
0.00
8.83
estimate
0.50
16
184
97
750
1.67
2.76
5.5
4.4
0.00
0.00
estimate
-0.00
14
164
8
19
4.36
2.71
1.3
1.6
—
—
—
0
0
68
486
1.66
2.58
4.0
3.5
—
—
—
0
0
16
70
2.42
2.50
5.4
3.8
0.97
0.81
%
0.83
16
65
68
490
1.64
2.48
5.9
5.5
—
—
—
0
0
116
956
1.65
2.43
7.0
5.2
416.29
283.96
e6/l
—
7
23
22
113
2.08
2.38
8.3
3.7
—
—
—
0
0
46
303
1.71
2.34
1.6
1.7
2.14
1.68
mg/l
0.24
36
242
58
410
1.62
2.25
7.1
6.6
—
—
—
0
0
29
171
1.84
2.14
1.6
1.8
—
—
—
0
0
75
571
1.55
2.10
5.9
4.5
0.00
0.02
estimate
0.50
13
151
8
27
3.06
1.96
1.1
1.4
—
—
—
0
0
0
51
0.00
1.92
0.0
4.6
—
—
—
0
0
7
22
3.27
1.90
1.4
3.5
—
—
—
0
0
95
776
1.50
1.85
12.6
9.4
4.31
4.41
e9/l
0.15
85
667
18
95
2.00
1.83
1.2
3.5
23.22
23.90
mmol/l
0.27
18
95
7
23
3.13
1.82
2.0
2.2
—
—
—
0
0
59
438
1.53
1.81
6.4
4.6
0.00
0.01
estimate
0.50
13
157
6
18
3.41
1.76
1.3
3.3
—
—
—
0
0
83
666
1.47
1.73
2.5
2.3
87.55
94.40
pmol/l
0.57
42
349
15
77
2.04
1.65
5.3
3.8
1.69
1.46
%
0.56
15
72
49
357
1.52
1.62
2.6
3.3
—
0.14
—
0
14
27
170
1.70
1.61
3.0
3.6
1.59
1.64
mmol/l
0.02
20
140
7
26
2.76
1.60
2.3
1.4
—
—
—
0
0
7
26
2.76
1.60
2.3
1.4
—
—
—
0
0
7
26
2.76
1.60
2.3
1.4
—
—
—
0
0
7
26
2.76
1.60
2.3
1.4
—
—
—
0
0
44
315
1.53
1.57
1.7
1.7
1133.47
1217.12
nmol/l
0.28
36
241
97
817
1.43
1.49
22.1
17.3
1.40
1.34
inr
0.40
83
690
68
538
1.43
1.47
3.8
3.7
136.62
161.45
e6/l
0.07
57
418
27
179
1.60
1.34
1.9
2.7
70.99
67.77
e9/l
0.14
18
135
63
503
1.40
1.27
7.0
4.7
—
—
—
0
0
120
1066
1.41
1.26
12.0
8.5
85.94
82.04
u/l
0.30
115
1001
93
793
1.37
1.25
10.2
7.2
1.20
1.21
mmol/l
0.05
83
670
5
19
2.68
1.22
1.2
1.7
—
—
—
0
0
103
895
1.37
1.22
8.1
5.2
6.61
6.93
mmol/l
1.17
98
861
26
175
1.57
1.22
3.1
3.7
5.64
5.68
kpa
0.06
26
170
26
176
1.56
1.19
3.2
3.5
7.39
7.38
ph
0.09
17
109
112
992
1.37
1.14
39.6
26.4
14.61
14.05
%
1.96
112
982
76
640
1.33
1.06
3.9
2.8
—
—
estimate
—
0
0
9
46
2.01
1.05
1.2
1.2
—
—
—
0
0
5
22
2.31
1.04
3.4
2.3
4.34
4.86
e9/l
—
5
22
24
165
1.53
1.04
2.0
1.4
—
—
—
0
0
0
32
0.00
0.96
0.0
1.4
—
—
—
0
0
61
505
1.32
0.94
3.2
3.5
6.48
7.66
mmol/l
1.57
54
420
21
144
1.52
0.92
6.0
7.9
—
—
—
0
0
6
28
2.18
0.92
1.7
1.3
—
—
—
0
0
5
104
0.47
0.92
1.4
3.2
—
—
—
0
0
22
153
1.50
0.91
1.7
1.3
—
—
—
0
0
24
327
0.69
0.89
1.4
1.3
—
—
—
0
0
11
64
1.77
0.88
1.1
1.2
—
—
—
0
0
33
423
0.73
0.86
3.1
3.3
0.76
0.80
ug/l
0.12
23
291
61
511
1.30
0.86
3.2
3.5
91.67
68.70
mg/l
0.22
45
352
125
1149
1.32
0.85
5.4
5.1
1.88
2.12
mu/l
1.20
110
1008
103
925
1.28
0.83
4.8
4.0
15.56
15.06
pmol/l
1.02
90
797
82
720
1.26
0.78
6.6
6.0
1.55
1.72
e9/l
0.97
71
630
83
730
1.26
0.78
6.9
6.1
0.15
0.20
e9/l
2.14
73
624
68
585
1.27
0.77
4.6
4.4
129.65
101.80
e6/l
0.16
54
434
5
24
2.11
0.75
1.2
2.5
30.00
32.13
pg
—
5
24
5
25
2.03
0.73
4.0
1.8
87.36
90.12
%
—
5
25
42
344
1.29
0.69
2.9
3.3
540.73
541.71
mosm/kgh2o
0.01
37
302
31
243
1.34
0.69
2.5
1.9
—
—
—
0
0
61
525
1.25
0.67
3.9
4.2
11.52
11.32
mg/mmol
0.01
45
349
17
233
0.70
0.66
1.3
1.5
2.32
3.06
g/l
0.95
11
140
39
319
1.29
0.65
3.9
3.1
2.45
2.47
mmol/l
0.24
34
286
80
712
1.23
0.65
6.7
5.9
0.59
0.63
e9/l
0.61
68
600
80
714
1.22
0.63
6.8
5.9
0.04
0.04
e9/l
0.07
68
602
50
424
1.25
0.62
4.6
3.9
0.00
0.00
estimate
-0.00
12
142
5
30
1.69
0.62
7.8
3.3
14.92
11.32
pmol/l
—
5
30
12
80
1.54
0.61
2.0
3.4
—
—
—
0
0
20
149
1.39
0.61
2.5
2.1
354.47
395.33
nmol/l
0.41
15
134
6
37
1.64
0.56
10.0
3.2
—
—
—
0
0
52
450
1.22
0.54
3.5
3.6
0.86
0.46
e6/l
0.38
42
335
133
1263
1.23
0.50
33.2
20.3
27.86
27.38
mg/l
0.05
118
1100
7
106
0.65
0.50
8.1
2.5
17.12
10.50
g/l
—
7
94
12
85
1.44
0.48
5.1
3.5
25.62
24.38
mmol/l
0.53
12
80
31
257
1.25
0.47
3.2
3.5
2.24
1.30
e6/l
0.48
17
139
33
276
1.24
0.47
6.4
5.4
—
—
—
0
0
16
121
1.36
0.46
5.1
4.6
—
—
—
0
0
9
130
0.68
0.45
1.9
1.5
—
—
—
0
0
5
31
1.63
0.43
3.4
2.1
61.20
58.46
%
—
5
31
10
138
0.71
0.42
1.5
1.4
—
—
—
0
0
0
17
0.00
0.41
0.0
1.0
—
—
—
0
0
33
384
0.83
0.40
4.0
3.9
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
133
1275
1.19
0.38
33.7
18.7
—
—
—
0
0
16
126
1.30
0.36
3.3
3.8
0.21
0.56
%
—
7
42
5
79
0.62
0.36
2.0
2.5
—
13.98
—
0
6
14
109
1.31
0.34
5.6
4.0
—
—
—
0
0
17
138
1.26
0.32
3.9
3.8
0.86
1.06
%
—
7
49
116
1210
0.87
0.32
5.5
5.6
4.25
4.29
mmol/l
0.13
108
1094
69
742
0.88
0.30
7.2
6.0
5.25
2.56
ug/l
0.39
64
650
7
55
1.28
0.30
2.9
2.7
1.94
1.76
mg/l
—
7
46
7
57
1.24
0.29
1.0
1.3
—
—
—
0
0
52
477
1.13
0.26
1.8
2.0
1.41
1.29
mmol/l
0.34
41
374
52
478
1.13
0.26
3.4
2.3
—
—
—
0
0
10
78
1.30
0.24
2.4
2.5
—
—
—
0
0
5
38
1.32
0.23
1.4
1.6
322.60
249.44
ug/g
—
5
27
5
38
1.32
0.23
2.2
1.1
—
—
—
0
0
66
619
1.11
0.23
18.7
13.8
0.00
0.00
e9/l
0.60
53
513
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.8
—
41.72
—
0
10
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
6
48
1.26
0.20
1.2
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
3.4
—
—
—
0
0
137
1338
1.11
0.19
47.3
30.3
92.25
91.98
fl
0.23
137
1318
113
1165
0.91
0.19
4.5
4.7
1.40
1.26
mmol/l
1.16
106
1034
21
185
1.15
0.19
1.3
1.4
—
—
—
0
0
15
128
1.19
0.19
4.0
3.9
0.40
0.21
%
—
5
39
117
1204
0.91
0.18
5.1
5.5
1.42
1.40
mmol/l
0.14
109
1076
137
1339
1.11
0.18
47.6
30.4
6.74
7.01
e9/l
0.98
137
1301
137
1339
1.11
0.18
47.8
30.6
127.77
132.90
g/l
3.08
137
1318
137
1339
1.11
0.18
48.0
30.8
38.63
39.62
%
1.28
137
1318
137
1339
1.11
0.18
47.5
30.3
4.24
4.39
e12/l
2.45
137
1301
137
1339
1.11
0.18
47.4
30.2
30.44
30.54
pg
0.20
137
1319
137
1339
1.11
0.18
47.7
30.4
230.36
233.02
e9/l
0.20
137
1308
28
253
1.13
0.18
10.2
5.9
104.18
104.15
mmol/l
0.01
28
253
5
70
0.71
0.17
1.0
1.3
—
27.06
—
0
8
49
521
0.92
0.16
2.3
2.4
—
—
—
0
0
133
1301
1.10
0.16
17.1
13.1
25.03
24.01
u/l
0.28
127
1257
16
141
1.15
0.14
3.1
2.3
—
—
—
0
0
27
248
1.11
0.13
1.2
1.2
1.32
0.93
u/ml
—
6
70
10
86
1.17
0.11
15.7
3.9
36.85
36.90
°c
—
10
86
12
106
1.14
0.10
1.4
1.4
—
—
—
0
0
71
688
1.05
0.09
6.5
4.6
60.05
51.91
ng/l
0.12
51
561
21
194
1.09
0.09
1.3
1.3
15.66
37.94
iu/ml
1.84
14
65
12
107
1.13
0.08
1.8
1.6
—
—
—
0
0
122
1239
0.95
0.08
6.1
6.5
2.30
2.44
mmol/l
1.19
111
1115
8
74
1.08
0.07
1.3
1.2
—
—
—
0
0
118
1198
0.95
0.07
8.5
7.8
40.62
41.04
mmol/mol
0.23
112
1105
11
118
0.93
0.03
1.5
1.4
—
—
—
0
0
12
128
0.93
0.02
1.9
2.0
—
0.00
estimate
—
0
23
123
1221
1.03
0.02
6.3
5.9
6.06
6.18
mmol/l
0.58
112
1093
14
133
1.06
0.01
3.6
4.2
0.00
0.36
%
—
5
39
17
171
0.99
0.00
1.7
1.3
413.33
490.43
titre
—
6
46
15
147
1.02
0.00
4.2
2.9
4.35
4.30
kpa
0.05
15
142
18
177
1.02
0.00
3.7
4.7
4.21
69.61
ug/l
0.87
18
151
17
172
0.99
0.00
1.2
1.4
1.25
22.93
u/ml
—
6
57
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
6
64
0.94
-0.00
1.3
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
86.43
—
0
7
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
9
97
0.92
-0.00
1.3
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
110.90
—
0
5
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
9.55
—
0
6
0
6
0.00
-0.00
0.0
6.5
—
50.83
—
0
6
8
83
0.96
-0.00
1.8
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
160.00
—
0
5
0
7
0.00
-0.00
0.0
1.1
—
1.95
—
0
7
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

↥

This endpoint is excluded (not available in FinRegistry).

Relationships between endpoints

↥

Index endpoint: K11_OESULC_ADVERSE – Ulcer of oesophagus, drug-induced

GWS hits: -

This endpoint is excluded (not available in FinRegistry).