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Crohn's disease (strict) with PSC

DOID EFO Endpoint Browser PheWeb

K11_CD_STRICT_PSC

ileocolitis: Ileocolitis or ileal Crohn's is the most common type of Crohn's disease. It affects both the ileum (small intestine) and the colon.

Suggest a new description

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

  • K11_CHOLANGI_STRICT
  • and K11_CD_STRICT
70

3. Check pre-conditions, main-only, mode, registry filters

None

0 out of 7 registries used, show all original rules.

0

4. Check minimum number of events

None

0

5. Include endpoints

70

6. Filter based on genotype QC (FinnGen only)

66

Control definitions (FinnGen only)

Control exclude
K11_IBD, K11_CHOLANGI
Control conditions
not K11_CHOLANGI_STRICT
and not K11_CD_STRICT

Extra metadata

First used in FinnGen datafreeze
DF3

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 159 66 91
Only index persons 154 65 89
Unadjusted period prevalence (%)
Whole population 0.00 0.00 0.00
Only index persons 0.00 0.00 0.00
Median age at first event (years)
Whole population 30.30 29.94 30.31
Only index persons 30.01 29.61 30.31

-FinnGen-

Key figures

All Female Male
Number of individuals 66 35 31
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 31.36 31.18 31.55

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
67
Matched controls
670
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
208
Kela drug reimbursment
Ulcerative colitis and Crohn's disease
+∞
96.2
67
*
K83.0
ICD-10 Finland
Cholangitis
+∞
96.2
67
*
A05AA02
ATC
ursodeoxycholic acid; oral
3904.4
83.8
64
*
A07EC02
ATC
mesalazine; oral, rectal
2047.8
77.5
61
*
UJF30
NOMESCO Finland
Ileoscopy through colon
79.3
72.1
46
18
K50.8
ICD-10 Finland
Other Crohn disease
+∞
70.9
55
*
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
+∞
69.3
67
34
JKE98
NOMESCO Finland
Other transduodenal endoscopic operation on bile duct or ampulla of Vater
2399.0
65.8
53
*
K50.1
ICD-10 Finland
Crohn disease of large intestine
+∞
59.5
48
*
UJF32
NOMESCO Finland
Coloscopy
39.3
49.8
54
64
L04AX01
ATC
azathioprine; systemic
361.4
46.4
42
*
K50.9
ICD-10 Finland
Crohn disease, unspecified
959.5
46.1
40
*
A07EA06
ATC
budesonide; oral, local oral
136.7
40.0
40
7
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
25.0
37.7
33
25
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
19.8
35.1
47
71
K50.0
ICD-10 Finland
Crohn disease of small intestine
+∞
33.1
29
*
K51.9
ICD-10 Finland
Ulcerative colitis, unspecified
+∞
31.8
28
*
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
389.5
26.7
25
*
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
110.3
26.2
27
*
JL5SB
NOMESCO Finland
Endoscopic retrograd cholangiopancreaticography
365.5
25.5
24
*
K51.5
ICD-10 Finland
Left sided colitis
365.5
25.5
24
*
326
Kela drug reimbursment
Adalimumab, golimumab, infliximab and ustekinumab (intestinal diseases)
+∞
23.3
21
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
11.3
23.1
41
82
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
9.6
19.6
44
111
L04AB04
ATC
adalimumab; parenteral
69.8
18.2
20
*
UJK02
NOMESCO Finland
ERCP
120.6
17.5
18
*
TPH04
NOMESCO Finland
Cathetrisation of vein
8.3
16.9
33
70
WX402
NOMESCO Finland
General anaesthesia
8.0
16.8
39
99
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
8.9
16.7
28
50
JN1DG
NOMESCO Finland
Very extensive MRI examination of upper part of abdomen with high intensity magnet
51.9
16.4
19
5
J01MA12
ATC
levofloxacin; systemic
8.1
15.9
30
61
JL5BG
NOMESCO Finland
MRI examinaiton of bile and pancreas ducts with high intesity magnet
74.4
15.6
17
*
JL5AG
NOMESCO Finland
Simple MRI examinaiton of bile and pancreas ducts with high intesity magnet
+∞
15.2
14
*
L01BB02
ATC
mercaptopurine; oral
94.8
14.2
15
*
Z2221
NOMESCO Finland
Medical doctor
6.9
14.2
42
131
K51.1
ICD-10 Finland
Ulcerative (chronic) ileocolitis
+∞
14.0
13
*
P01AB01
ATC
metronidazole; oral, rectal
7.7
14.0
50
185
ZXD10
NOMESCO Finland
Scheduled procedure
6.8
13.7
44
147
K51.8
ICD-10 Finland
Other ulcerative colitis
86.9
13.1
14
*
UJF92
NOMESCO Finland
Capsular endoscopy
86.9
13.1
14
*
K80.3
ICD-10 Finland
Calculus of bile duct with cholangitis
+∞
12.9
12
*
UJK12
NOMESCO Finland
Peroral cholangioscopy
+∞
12.9
12
*
JF1CG
NOMESCO Finland
Extensive MRI of small bowel
+∞
12.9
12
*
H02AB06
ATC
prednisolone; systemic
6.7
11.9
50
205
JJ9AE
NOMESCO Finland
Ultrasound examination of liver transplant
+∞
11.8
11
*
Z94.4
ICD-10 Finland
Liver transplant status
+∞
11.8
11
*
JJC00
NOMESCO Finland
Allogenic transplantation of liver
+∞
11.8
11
*
ZXE00
NOMESCO Finland
One hour or less
5.7
11.0
45
177
ZX120
NOMESCO Finland
Intravenous
13.5
10.9
19
19
JJ1LE
NOMESCO Finland
Ultrasound elastography of liver
+∞
10.7
10
*
K83.8
ICD-10 Finland
Other specified diseases of biliary tract
+∞
10.7
10
*
K74.3
ICD-10 Finland
Primary biliary cirrhosis
+∞
10.7
10
*
K83.9
ICD-10 Finland
Disease of biliary tract, unspecified
+∞
10.7
10
*
JN3AD
NOMESCO Finland
Abdominal CT examination
6.5
10.7
22
47
GD1AA
NOMESCO Finland
Thorax X-ray examination
5.4
10.0
46
194
J01MA02
ATC
ciprofloxacin; systemic
5.1
10.0
41
158
A07EA02
ATC
hydrocortisone; rectal
115.7
9.7
10
*
256, ,
Kela drug reimbursment
+∞
9.6
9
*
K51.0
ICD-10 Finland
Ulcerative (chronic) pancolitis
+∞
9.6
9
*
WX002
NOMESCO Finland
Sedation and analgesia
5.8
9.5
22
52
K83.1
ICD-10 Finland
Obstruction of bile duct
43.1
9.3
11
*
L04AC05
ATC
ustekinumab; parenteral
57.8
8.9
10
*
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
23.9
8.8
12
6
WX302
NOMESCO Finland
Thoracal epidural anesthesy
23.9
8.8
12
6
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
102.4
8.6
9
*
601
Kela drug reimbursment
Severe malabsorption of nutrients, mainly fats
102.4
8.6
9
*
JN3DE
NOMESCO Finland
Abdominal extensive ultrasoudn examination with blood flow measurements after transplantation
102.4
8.6
9
*
UJF02
NOMESCO Finland
Peroral enteroscopy
+∞
8.5
8
*
127
Kela drug reimbursment
Transplant complication
25.8
8.3
11
5
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
13.2
8.3
14
13
N02AX02
ATC
tramadol; systemic, rectal
4.4
8.2
41
177
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
11.5
7.7
14
15
H02AB07
ATC
prednisone; oral
7.1
7.7
19
35
K76.9
ICD-10 Finland
Liver disease, unspecified
+∞
7.4
7
*
L04AD01
ATC
ciclosporin; systemic
23.1
7.4
10
5
JL5CG
NOMESCO Finland
Extensive MRI examinaiton of bile and pancreas ducts with high intesity magnet
34.1
7.3
9
*
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
9.5
7.0
14
18
A07EC01
ATC
sulfasalazine; oral, rectal
8.4
7.0
15
22
JN3BD
NOMESCO Finland
Extensive abdominal CT
7.0
6.9
17
31
H02AB04
ATC
methylprednisolone; systemic
6.4
6.8
18
36
Z3226
NOMESCO Finland
Physiotherapist
4.1
6.6
24
80
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
12.9
6.6
11
10
TK800
NOMESCO Finland
Hemodialysis
29.8
6.4
8
*
L04AA06
ATC
mycophenolic acid; systemic
29.8
6.4
8
*
UJF12
NOMESCO Finland
Enteroscopy through intestinal stoma
+∞
6.3
6
*
M07.4*K50.9
ICD-10 Finland
Arthropathy in Crohn's disease [regional enteritis]
+∞
6.3
6
*

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
57
36
100.38
76.00
8.4
4.0
2.10
3.72
ug/l
1.00
44
27
54
57
44.67
53.81
3.6
1.2
—
—
—
0
0
38
20
42.59
52.35
3.2
1.1
—
—
—
0
0
45
8
164.13
46.09
5.3
2.3
3.74
11.38
u/ml
—
45
8
40
12
79.38
36.59
3.4
1.1
—
—
—
0
0
44
83
13.53
26.66
3.8
1.4
450.53
606.67
titre
0.39
19
18
40
79
11.08
22.76
2.9
2.2
—
—
—
0
0
25
6
64.76
22.38
2.2
1.0
107.86
—
titre
—
14
0
25
6
64.76
22.38
2.2
1.0
—
—
—
0
0
56
213
10.92
15.85
11.5
7.5
1.21
1.22
mmol/l
0.54
56
202
47
155
7.81
15.20
4.1
1.5
2.53
2.30
g/l
0.47
42
95
42
133
6.78
13.89
8.0
3.4
7.39
7.40
ph
0.85
32
91
32
79
6.84
13.76
1.7
1.5
—
—
—
0
0
19
11
23.46
13.49
1.5
1.5
518.71
150.00
u/ml
—
14
5
48
182
6.77
12.71
6.0
2.3
—
—
—
0
0
19
14
18.38
12.40
1.3
1.4
—
—
—
0
0
50
204
6.72
11.97
2.9
2.0
98.19
96.16
pmol/l
0.12
35
115
20
35
7.72
11.81
1.5
1.3
—
—
—
0
0
55
256
7.41
10.99
28.4
9.5
0.00
0.00
e9/l
0.50
47
203
44
171
5.58
10.84
16.0
6.4
—
—
—
0
0
20
24
11.37
10.52
1.5
1.4
—
—
—
0
0
23
52
6.21
10.52
4.8
7.0
7.36
7.39
ph
1.19
17
23
25
63
5.74
10.15
1.6
1.3
—
—
—
0
0
49
217
5.68
10.06
3.6
1.6
—
—
—
0
0
13
6
26.34
9.79
1.2
1.2
—
—
—
0
0
13
7
22.56
9.36
1.2
1.0
—
—
—
0
0
21
51
5.54
8.76
5.0
7.3
5.86
5.95
kpa
0.21
21
51
8
0
+∞
8.50
1.6
0.0
—
—
—
0
0
12
7
20.46
8.43
1.4
1.0
1.64
1.23
g/l
—
12
7
35
135
4.33
8.16
1.9
1.7
—
—
—
0
0
34
132
4.20
7.79
13.4
4.4
—
—
—
0
0
18
36
6.44
6.82
3.2
7.9
22.96
24.26
mmol/l
1.02
18
36
23
73
4.27
6.80
1.7
1.4
—
—
—
0
0
21
64
4.32
6.52
12.4
11.1
106.71
105.16
mmol/l
0.94
21
64
49
272
3.98
6.22
6.3
2.6
—
—
estimate
—
0
0
16
41
4.81
6.13
4.8
6.5
0.33
0.88
%
—
9
16
15
29
6.35
5.83
1.5
1.2
—
—
—
0
0
9
8
12.74
5.47
1.0
1.1
—
—
—
0
0
16
45
4.36
5.44
11.6
10.5
—
—
—
0
0
8
6
14.88
5.22
5.6
2.8
54.38
64.07
%
—
8
6
12
20
7.05
5.19
1.3
1.3
—
—
—
0
0
15
43
4.21
4.95
6.1
6.4
0.44
0.95
%
—
8
19
15
36
5.06
4.90
9.7
13.6
23.43
25.13
mmol/l
0.67
15
36
17
54
3.88
4.89
1.4
1.5
—
—
—
0
0
31
150
2.99
4.54
4.7
2.8
—
—
estimate
—
0
0
17
58
3.59
4.39
3.1
1.8
265.65
410.02
nmol/l
2.46
17
53
7
6
12.81
4.38
1.6
1.3
—
—
—
0
0
35
188
2.80
4.14
2.0
2.0
—
—
—
0
0
14
38
4.38
4.10
6.6
6.9
0.00
0.00
%
—
7
14
13
37
4.11
3.65
2.0
3.9
99.93
77.50
e9/l
—
7
26
36
206
2.62
3.64
6.0
3.7
17.46
121.81
e6/l
0.73
28
141
30
160
2.58
3.47
4.9
2.9
0.28
0.27
e6/l
0.02
25
119
13
39
3.88
3.47
2.4
7.8
4.35
4.63
kpa
0.29
13
39
7
10
7.66
3.45
1.1
1.1
—
—
—
0
0
32
179
2.51
3.32
4.8
3.0
26.25
72.85
e6/l
0.61
27
137
5
5
10.65
3.02
1.4
1.4
—
—
—
0
0
5
5
10.65
3.02
1.4
1.4
—
—
—
0
0
5
5
10.65
3.02
1.4
1.4
—
—
—
0
0
5
5
10.65
3.02
1.4
1.4
—
—
—
0
0
13
47
3.19
3.02
14.1
11.5
7.35
7.42
ph
—
5
30
52
378
2.68
2.90
7.4
4.3
—
—
—
0
0
12
40
3.43
2.88
7.2
6.6
0.00
0.13
%
—
5
16
30
175
2.29
2.72
1.4
1.5
0.49
2.26
u/ml
—
7
43
16
73
2.57
2.45
1.1
1.1
—
—
—
0
0
31
195
2.10
2.25
1.7
1.5
—
—
—
0
0
36
240
2.08
2.23
4.4
3.0
6.12
6.25
ph
0.29
17
130
22
121
2.22
2.23
3.3
1.9
0.63
0.69
mg/l
0.14
15
88
20
106
2.26
2.21
5.9
2.6
18.00
87.53
ng/l
0.60
13
64
8
25
3.49
2.17
1.1
1.2
—
—
—
0
0
8
27
3.22
2.01
15.9
13.5
96.50
94.41
%
—
8
27
8
27
3.22
2.01
15.9
13.4
0.64
0.70
%
—
8
27
8
27
3.22
2.01
15.9
13.5
1.34
1.34
%
—
8
27
41
295
2.00
1.98
5.8
3.2
0.00
0.00
estimate
—
8
55
41
297
1.98
1.92
5.7
3.2
0.00
0.00
estimate
—
8
56
23
136
2.05
1.91
4.7
3.2
—
—
—
0
0
6
17
3.77
1.88
9.8
4.4
24.20
24.71
mmol/l
—
6
17
6
17
3.77
1.88
9.5
1.8
22.43
24.18
mmol/l
—
6
17
7
23
3.27
1.85
1.7
1.2
—
—
—
0
0
41
300
1.94
1.83
6.0
3.3
0.00
0.00
estimate
—
8
50
7
24
3.13
1.77
7.0
4.5
—
—
—
0
0
25
157
1.94
1.74
2.4
2.1
89.44
138.16
u/l
1.19
25
152
7
26
2.88
1.63
17.9
13.6
22.00
24.40
mmol/l
—
7
26
5
17
3.09
1.38
1.2
1.8
137.26
68.29
ug/l
—
5
17
8
34
2.53
1.34
3.3
1.1
0.81
0.86
g/l
—
8
34
22
143
1.80
1.34
13.8
4.5
—
—
—
0
0
8
39
2.19
1.20
6.6
7.1
7.39
7.36
ph
—
8
34
0
34
0.00
1.20
0.0
1.1
—
1.54
—
0
34
18
262
0.57
1.18
2.9
2.5
—
—
—
0
0
7
33
2.25
1.09
1.0
2.2
—
—
—
0
0
21
150
1.58
0.88
6.2
3.1
0.00
0.00
estimate
—
6
51
24
177
1.55
0.88
2.7
2.4
24.33
16.47
ng/l
0.36
16
96
19
137
1.54
0.76
2.7
3.0
—
—
—
0
0
11
69
1.71
0.74
2.0
1.6
—
—
—
0
0
6
103
0.54
0.69
1.3
1.3
—
—
—
0
0
12
79
1.63
0.68
1.5
1.6
—
—
—
0
0
18
133
1.48
0.64
3.4
2.7
—
—
—
0
0
21
161
1.44
0.62
5.0
2.6
0.00
0.00
estimate
—
8
42
6
35
1.78
0.59
4.5
2.7
—
—
—
0
0
19
146
1.42
0.55
4.3
4.2
15.70
12.94
mg/mmol
0.10
12
95
26
216
1.33
0.47
6.1
3.0
0.00
0.00
estimate
—
8
43
18
142
1.37
0.45
7.3
3.2
1.02
1.02
kg/l
0.13
13
84
0
16
0.00
0.41
0.0
1.8
—
—
—
0
0
9
123
0.69
0.39
1.7
1.5
—
—
—
0
0
9
120
0.71
0.39
1.8
1.7
—
—
—
0
0
18
145
1.33
0.39
3.9
3.7
92.31
84.80
mg/l
0.05
12
100
59
561
1.43
0.32
5.0
3.6
1.19
1.27
mmol/l
0.51
53
535
5
41
1.24
0.22
1.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
28.1
—
1634.18
—
0
11
0
11
0.00
0.21
0.0
20.9
—
905.09
—
0
11
0
10
0.00
0.21
0.0
1.1
—
214.70
—
0
10
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
5
66
0.74
0.18
2.2
2.4
—
—
—
0
0
6
73
0.80
0.08
1.0
1.3
—
—
—
0
0
9
87
1.04
0.07
1.3
2.8
2.44
2.43
mmol/l
—
9
81
12
125
0.95
0.00
1.4
1.3
—
26.36
—
0
44
0
5
0.00
-0.00
0.0
1.2
—
97.20
—
0
5
0
5
0.00
-0.00
0.0
1.4
—
2.16
—
0
5
0
6
0.00
-0.00
0.0
2.0
—
0.52
—
0
6
5
56
0.88
-0.00
1.2
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
11.7
—
0.62
—
0
9
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.6
—
69.86
—
0
7
0
6
0.00
-0.00
0.0
2.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
32.48
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
262.50
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
56
0.88
-0.00
1.2
1.4
—
—
—
0
0
5
51
0.98
-0.00
2.0
1.2
—
31.36
—
0
5
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
5
56
0.88
-0.00
1.2
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
5.0
—
98.38
—
0
5
5
56
0.88
-0.00
1.2
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
329.22
—
0
9

Mortality – FinRegistry

↥

Association

Association between endpoint K11_CD_STRICT_PSC and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have K11_CD_STRICT_PSC.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

↥

Index endpoint: K11_CD_STRICT_PSC – Crohn's disease (strict) with PSC

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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