Interstitial cystitis (chronic), drug-induced

INTERSTITIAL_CYSTIT_CHRONIC

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ATC codes for adverse effects of Drugs ANY
  • Hospital discharge: ICD-10 N30.1#

1 out of 7 registries used, show all original rules.

123

4. Check minimum number of events

None

123

5. Include endpoints

None

123

6. Filter based on genotype QC (FinnGen only)

118

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF5

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (not available in FinRegistry).

-FinnGen-

Key figures

All Female Male
Number of individuals 118 105 13
Unadjusted period prevalence (%) 0.03 0.04 0.01
Median age at first event (years) 50.13 49.94 51.65

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
120
Matched controls
1200
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
N30.1
ICD-10 Finland
Interstitial cystitis (chronic)
+∞
161.1
120
8
KCV04
NOMESCO Finland
Distension of bladder with fluid
507.6
85.7
76
*
UKC02
NOMESCO Finland
Cystoscopy
31.6
84.5
88
96
G04BD07
ATC
tolterodine; oral
17.5
49.7
50
47
G04BD04
ATC
oxybutynin; oral, transdermal
15.5
49.7
57
66
5951A
ICD-9 Finland
Cystitis, Chronic interstitial cystitis
+∞
34.0
31
*
7325
FHL
Bladder stretching
+∞
31.7
29
*
XKD00
NOMESCO Finland
Uroflowmetry
10.4
30.6
42
59
R35
ICD-10 Finland
Polyuria
8.4
21.4
33
52
59504
ICD-8 Finland
Cystitis, Interstitialis (Hunner)
237.6
20.2
20
*
1530
FHL
Urethrocystoscopy
46.8
19.4
23
6
TKD00
NOMESCO Finland
Dilatation of urethra
111.9
18.1
19
*
N30.0
ICD-10 Finland
Acute cystitis
4.7
15.3
51
162
J01MA06
ATC
norfloxacin; oral
4.8
15.1
49
152
ZX136
NOMESCO Finland
Intravesicalis
91.6
15.0
16
*
J01EA01
ATC
trimethoprim; systemic
4.3
14.2
70
294
N06CA01
ATC
amitriptyline and psycholeptics; systemic
5.4
14.1
34
82
G04BD
ATC
Drugs for urinary frequency and incontinence
157.0
13.8
14
*
N31.1
ICD-10 Finland
Reflex neuropathic bladder, not elsewhere classified
45.6
13.5
16
*
N30.9
ICD-10 Finland
Cystitis, unspecified
5.4
11.9
27
61
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
5.7
11.8
25
53
KCV02
NOMESCO Finland
Cystoscopic balloon distension of bladder
+∞
11.6
11
*
L04AA01
ATC
[U] ciclosporin
28.3
11.5
15
6
7321
FHL
TU biopsy, coagulation or laser
+∞
10.6
10
*
J01MA02
ATC
ciprofloxacin; systemic
3.6
10.5
74
373
N02AX02
ATC
tramadol; systemic, rectal
3.5
10.4
75
384
UJF32
NOMESCO Finland
Coloscopy
3.5
10.3
53
219
TKC20
NOMESCO Finland
Catheterisation of bladder
5.5
10.2
22
47
P01BA02
ATC
hydroxychloroquine; oral
4.5
9.7
27
72
G04AC01, ,
ATC
9.0
9.6
20
26
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.2
9.2
59
276
G04BD01
ATC
emepronium; systemic
20.6
9.2
13
7
N32.82
ICD-10 Finland
Instability of the detrusor vesicae muscle
26.4
9.1
12
5
A03FA02
ATC
cisapride; oral, rectal
4.7
8.8
23
58
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
3.1
8.8
65
328
J01MA01
ATC
ofloxacin; systemic
4.5
8.7
24
63
R30.0
ICD-10 Finland
Dysuria
8.1
8.7
19
27
N06AA09
ATC
amitriptyline; systemic
4.0
8.2
27
81
R01AD12
ATC
fluticasone furoate; nasal
3.1
8.0
50
226
XKD06
NOMESCO Finland
Physiologic investigation of micturition
9.9
7.8
15
17
R30.1
ICD-10 Finland
Vesical tenesmus
13.1
7.8
13
11
G04BD12
ATC
mirabegron; oral
3.7
7.7
29
96
G44.2
ICD-10 Finland
Tension-type headache
3.6
7.2
28
94
A03CA02
ATC
clidinium and psycholeptics; oral
4.6
7.1
18
44
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
2.9
6.8
42
187
ZXD10
NOMESCO Finland
Scheduled procedure
2.7
6.8
64
355
J01CA08
ATC
pivmecillinam; oral
2.9
6.5
85
550
G03CA04
ATC
estriol; systemic, vaginal
3.5
6.5
25
83
90621, ,
NOMESCO Finland
73.6
6.5
7
*
D13.1
ICD-10 Finland
Benign neoplasm: Stomach
12.0
6.4
11
10
G04BD11
ATC
fesoterodine; oral
7.8
6.4
14
20
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
2.7
6.4
52
266
KCC00
NOMESCO Finland
Cystectomy
+∞
6.3
6
*
7362
FHL
Urethral dilatation in anesthesia or operating room
+∞
6.3
6
*
U07
ICPC
Urine symptom/complaint other
3.6
6.3
23
74
A02BA02
ATC
ranitidine; systemic
2.8
6.2
39
174

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
23
92
2.86
4.36
5.1
6.0
—
—
—
0
0
63
409
2.14
4.04
5.1
3.6
—
—
—
0
0
22
91
2.74
3.91
3.7
2.6
0.21
1.61
e6/l
0.72
22
85
45
265
2.12
3.64
9.4
4.6
1.01
1.02
kg/l
0.69
34
171
12
34
3.80
3.31
1.6
2.8
—
—
—
0
0
57
381
1.94
3.16
6.7
3.5
30.76
227.52
e6/l
0.60
49
290
25
123
2.30
3.10
2.9
3.7
7.37
7.39
ph
0.67
16
79
15
59
2.76
2.91
4.1
1.7
—
—
—
0
0
37
219
2.00
2.87
6.1
4.3
575.63
163.25
ng/l
0.67
27
183
32
185
2.00
2.63
6.8
3.1
3.55
3.67
e6/l
0.03
20
88
31
178
2.00
2.59
1.9
3.2
0.83
0.80
mmol/l
0.68
31
161
49
329
1.83
2.56
5.9
3.4
0.23
0.50
e6/l
1.15
44
240
43
282
1.82
2.40
9.1
4.2
—
0.00
—
0
6
15
67
2.42
2.28
6.6
5.5
25.58
24.92
mmol/l
0.34
15
67
61
450
1.72
2.24
7.9
4.6
0.00
0.00
estimate
—
10
103
15
70
2.31
2.08
1.1
1.2
37.64
159.11
u/ml
—
7
30
54
393
1.68
2.03
2.9
2.2
111.90
201.37
u/l
1.12
49
369
17
86
2.14
1.96
1.8
1.6
—
—
—
0
0
76
609
1.68
1.95
8.7
4.5
0.00
0.00
estimate
-0.00
17
121
63
482
1.65
1.93
7.7
4.1
6.46
6.26
ph
0.74
40
270
7
24
3.03
1.75
1.4
2.4
77.34
54.08
%
—
7
24
47
343
1.61
1.69
9.6
4.4
0.00
0.00
estimate
-0.00
15
119
10
41
2.57
1.69
1.4
1.3
1.35
1.20
g/l
—
10
41
39
272
1.64
1.68
1.4
1.2
0.56
2.25
u/ml
1.09
11
71
74
603
1.59
1.66
8.6
4.5
0.00
0.00
estimate
-0.00
16
126
5
14
3.68
1.63
1.2
1.0
—
—
—
0
0
5
14
3.68
1.63
1.6
2.6
13.00
9.96
%
—
5
14
74
610
1.56
1.52
8.8
4.5
0.00
0.00
estimate
-0.00
17
131
55
425
1.54
1.51
3.0
3.5
2.39
2.36
mmol/l
0.88
50
390
56
435
1.54
1.50
9.1
4.3
436.53
105.32
e6/l
0.51
51
299
50
380
1.54
1.48
3.4
3.7
7.40
7.40
ph
0.06
39
272
9
40
2.35
1.43
1.4
1.3
0.25
0.23
g/l
—
9
40
45
338
1.53
1.39
5.8
6.6
—
—
—
0
0
12
61
2.07
1.38
1.4
1.4
—
—
—
0
0
14
76
1.95
1.36
1.8
2.6
1.24
1.21
%
0.05
14
76
33
234
1.57
1.30
6.5
4.9
—
—
—
0
0
59
476
1.47
1.26
11.6
11.8
0.00
0.00
e9/l
0.80
53
385
13
72
1.90
1.20
7.3
5.9
95.42
94.42
%
0.72
13
72
18
111
1.73
1.20
3.2
2.6
6.20
6.17
ph
—
10
78
13
75
1.82
1.08
1.8
2.6
0.53
0.63
%
0.58
13
75
45
354
1.43
1.06
1.6
1.7
21.30
21.91
nmol/l
0.09
38
297
5
22
2.33
1.04
1.0
1.6
—
—
—
0
0
10
54
1.93
1.00
1.8
1.6
4.66
9.07
iu/ml
—
5
15
7
36
2.00
0.99
1.0
1.2
—
—
—
0
0
62
522
1.39
0.98
13.0
14.9
1.35
1.24
inr
0.63
55
436
0
31
0.00
0.98
0.0
1.3
—
333.73
—
0
18
22
152
1.55
0.97
4.9
1.8
29.65
28.98
s
0.14
22
146
58
487
1.37
0.91
6.9
5.6
2.23
2.65
%
0.88
58
454
58
487
1.37
0.91
6.9
5.7
0.57
0.67
%
0.87
58
452
10
56
1.86
0.91
4.2
3.5
37.00
36.91
°c
—
10
56
6
29
2.12
0.90
1.0
1.8
6.18
6.50
pmol/l
—
6
29
69
597
1.37
0.89
6.3
5.8
1.22
1.22
mmol/l
0.03
61
513
29
217
1.44
0.88
1.6
1.3
16.83
41.16
iu/ml
—
6
76
31
235
1.43
0.88
1.5
1.4
2.03
2.45
g/l
0.61
18
134
58
490
1.36
0.87
6.9
5.7
7.73
8.72
%
2.25
58
462
22
156
1.50
0.87
1.4
1.2
—
—
—
0
0
21
149
1.50
0.83
1.5
1.4
286.67
585.64
titre
1.26
12
39
73
642
1.35
0.83
5.3
4.8
6.53
6.61
mmol/l
0.19
67
599
27
202
1.43
0.82
1.6
1.3
31.96
10.35
u/ml
0.34
12
78
53
445
1.34
0.81
6.9
4.4
33.33
36.14
ng/l
0.08
32
323
19
134
1.50
0.77
6.1
5.3
13.18
11.64
kpa
0.65
19
128
19
134
1.50
0.77
6.1
5.3
5.34
5.17
kpa
0.44
19
128
5
23
2.22
0.77
4.8
2.3
—
—
—
0
0
57
487
1.32
0.77
6.6
5.6
57.94
57.68
%
0.05
57
462
68
597
1.32
0.75
7.8
9.5
4.07
4.11
e9/l
0.05
62
528
58
498
1.32
0.75
6.9
5.7
27.89
27.48
%
0.09
58
472
12
76
1.64
0.75
3.0
3.6
—
—
—
0
0
11
68
1.68
0.74
1.2
1.6
—
—
—
0
0
38
308
1.34
0.73
3.9
4.0
—
—
—
0
0
19
137
1.46
0.70
2.8
4.0
1.04
1.09
mmol/l
0.45
19
119
28
352
0.73
0.70
3.4
3.4
—
—
—
0
0
19
138
1.45
0.68
1.2
1.2
—
—
—
0
0
5
29
1.75
0.64
4.8
2.6
47.00
61.86
%
—
5
29
18
131
1.44
0.64
6.4
5.4
7.44
7.42
ph
—
10
86
5
30
1.69
0.62
1.2
1.1
—
—
—
0
0
13
90
1.50
0.58
2.9
5.9
9.25
9.43
mmol/l
0.03
13
83
17
125
1.42
0.57
1.9
1.5
—
—
—
0
0
18
134
1.40
0.57
3.5
3.1
4.16
5.96
e9/l
0.50
18
118
9
62
1.49
0.54
1.9
3.4
24.34
24.97
mmol/l
—
9
62
41
349
1.27
0.54
6.6
5.3
—
—
—
0
0
89
830
1.28
0.52
6.5
4.8
15.03
14.90
pmol/l
0.20
84
745
51
449
1.24
0.50
2.1
2.1
—
—
—
0
0
12
86
1.44
0.46
1.3
1.4
—
—
—
0
0
9
126
0.69
0.46
6.2
2.7
1.42
1.89
%
—
9
118
8
55
1.49
0.44
4.1
2.4
—
—
—
0
0
5
31
1.64
0.43
1.0
1.1
—
—
—
0
0
8
57
1.43
0.43
1.6
1.2
—
—
—
0
0
23
278
0.79
0.42
1.4
1.4
—
—
—
0
0
0
15
0.00
0.41
0.0
1.0
—
—
—
0
0
0
15
0.00
0.41
0.0
1.2
—
—
—
0
0
0
16
0.00
0.41
0.0
1.8
—
—
—
0
0
40
350
1.21
0.40
2.8
3.7
2.25
6.97
mg/mmol
1.80
28
200
5
35
1.45
0.40
5.4
3.3
7.42
7.42
ph
—
5
35
6
89
0.66
0.34
12.8
2.9
58.50
74.28
e9/l
—
6
67
37
327
1.19
0.33
5.4
4.0
0.00
0.01
estimate
—
10
99
36
318
1.19
0.32
5.2
3.7
—
0.00
—
0
9
16
129
1.28
0.32
1.4
1.3
—
—
—
0
0
23
269
0.82
0.32
2.8
2.6
332.74
328.49
umol/l
0.05
23
234
56
515
1.16
0.31
2.5
2.1
112.09
98.30
pmol/l
0.91
20
248
8
110
0.71
0.30
1.0
1.4
—
—
—
0
0
95
984
0.83
0.28
7.1
6.2
2.61
2.66
mmol/l
0.22
90
906
8
63
1.29
0.28
1.4
1.7
—
—
—
0
0
87
831
1.17
0.28
27.2
21.2
13.76
13.81
%
0.11
87
821
38
342
1.16
0.27
2.7
3.1
9.46
39.24
mg/l
2.24
27
212
16
133
1.23
0.26
1.9
1.5
—
—
—
0
0
11
87
1.29
0.25
1.5
1.8
—
—
—
0
0
17
143
1.22
0.25
1.8
1.8
—
—
—
0
0
7
93
0.74
0.23
3.4
6.3
2.09
2.71
ug/l
—
7
84
13
107
1.24
0.22
1.2
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
2.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
16.36
—
0
10
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
7.35
—
0
13
0
14
0.00
0.20
0.0
1.6
—
—
—
0
0
5
69
0.71
0.17
1.0
1.3
—
—
—
0
0
15
131
1.17
0.15
1.3
1.6
—
—
—
0
0
99
1011
0.88
0.15
19.8
15.3
—
—
—
0
0
10
85
1.19
0.13
7.4
3.9
—
—
—
0
0
97
953
1.09
0.09
7.9
6.1
1.77
1.90
mu/l
0.56
91
879
17
155
1.11
0.09
1.9
1.9
—
—
—
0
0
33
348
0.93
0.09
2.1
2.1
—
—
—
0
0
5
63
0.78
0.08
1.2
1.3
—
—
—
0
0
47
485
0.95
0.06
3.0
2.7
—
—
estimate
—
0
0
101
1001
1.06
0.03
24.8
17.5
19.78
22.04
mg/l
0.44
92
822
10
92
1.09
0.03
1.3
1.1
—
—
—
0
0
25
242
1.04
0.02
1.7
1.8
462.65
470.15
pmol/l
0.04
20
197
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
5
59
0.84
0.00
1.0
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
1656.50
—
0
6
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
5.0
—
38.60
—
0
5
0
8
0.00
-0.00
0.0
1.6
—
15.01
—
0
8
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
52.20
—
0
5
0
6
0.00
-0.00
0.0
2.0
—
0.60
—
0
6
0
5
0.00
-0.00
0.0
2.4
—
1.19
—
0
5
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
3.6
—
—
—
0
0
7
70
1.00
-0.00
1.0
1.3
—
37.70
—
0
5
0
5
0.00
-0.00
0.0
3.0
—
6.82
—
0
5
0
7
0.00
-0.00
0.0
1.1
—
215.71
—
0
7
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
3.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded (not available in FinRegistry).

Relationships between endpoints

Index endpoint: INTERSTITIAL_CYSTIT_CHRONIC – Interstitial cystitis (chronic), drug-induced

GWS hits: -

This endpoint is excluded (not available in FinRegistry).