thromboangiitis obliterans: Buerger disease, also known as thromboangiitis obliterans (TAO), is a rare inflammatory non-necrotizing vascular disease affecting the small- and medium-sized arteries and veins of the upper and lower extremities characterized by endarteritis and vaso-occlusion due to occlusive thrombus development. The development and progression of the disease is consistently associated with exposure to tobacco.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
145 |
4. Check minimum number of eventsNone |
145 |
5. Include endpointsNone |
145 |
6. Filter based on genotype QC (FinnGen only) |
135 |
Control definitions (FinnGen only)
- Control exclude
- I9_DOAAC
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- I73
- Name in latin
- Tromboangi(i)tis obliterans (Bürger)
Similar endpoints
↥List of similar endpoints to
Thromboangiitis obliterans
based on the number of shared cases.
Similar with more cases:
- Other peripheral vascular diseases
- Diseases of arteries, arterioles and capillaries
- Cardiovascular diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1319 | 389 | 900 |
| Only index persons | 869 | 322 | 547 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.01 | 0.03 |
| Only index persons | 0.02 | 0.01 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 52.80 | 53.06 | 52.44 |
| Only index persons | 51.00 | 51.70 | 50.59 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 135 | 49 | 86 |
| Unadjusted period prevalence (%) | 0.03 | 0.02 | 0.04 |
| Median age at first event (years) | 49.50 | 46.58 | 51.16 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 136
- Matched controls
- 1360
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
I73.1
ICD-10 Finland
Thromboangiitis obliterans [Buerger]
+∞
118.8
96
*
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
136.1
60.2
61
8
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
21.3
41.5
34
21
44310
ICD-8 Finland
Other peripheral vascular disease, Thrombo-angiitis obliterans (Buerger's disease)
+∞
36.1
33
*
C08CA05
ATC
nifedipine; systemic
10.0
27.8
37
49
4431A
ICD-9 Finland
Other peripheral vascular disease, Thromboangiitis obliterans [Buerger's disease]
+∞
24.7
23
*
4402A
ICD-9 Finland
Atherosclerosis, Of native arteries of the extremities
+∞
14.9
14
*
I71.4
ICD-10 Finland
Abdominal aortic aneurysm, without mention of rupture
130.6
11.6
12
*
I73.0
ICD-10 Finland
Raynaud syndrome
47.5
11.1
13
*
2424
FHL
Sympatectomy, lumbar
+∞
10.5
10
*
C08CA02
ATC
felodipine; oral
4.4
10.1
29
79
PD4BC
NOMESCO Finland
Extensive arterigography of lower extremity with X-ray
+∞
9.5
9
*
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
10.6
9.1
17
18
I73.9
ICD-10 Finland
Peripheral vascular disease, unspecified
53.5
8.8
10
*
PD4AC
NOMESCO Finland
Arterigography of lower extremity with X-ray
53.5
8.8
10
*
I71.3
ICD-10 Finland
Abdominal aortic aneurysm, ruptured
+∞
8.4
8
*
I73.8
ICD-10 Finland
Other specified peripheral vascular diseases
+∞
8.4
8
*
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
12.8
8.3
14
12
I70.9
ICD-10 Finland
Generalized and unspecified atherosclerosis
84.5
7.5
8
*
J01FF01
ATC
clindamycin; systemic
2.8
7.4
50
232
PE1AT
NOMESCO Finland
Femoral artery PTA
+∞
7.4
7
*
9571
FHL
Amputation of toe or toes
+∞
7.4
7
*
M34.9
ICD-10 Finland
Systemic sclerosis, unspecified
+∞
7.4
7
*
2423
FHL
Sympatectomy, thoracic
+∞
7.4
7
*
PD4AD
NOMESCO Finland
CT of lower extremity arteries
+∞
6.3
6
*
PEH57
NOMESCO Finland
Bypass from femoral artery to popliteal artery below knee
+∞
6.3
6
*
9573
FHL
Leg amputation
+∞
6.3
6
*
PD3YT
NOMESCO Finland
Pelvic artery PTA with stent
+∞
6.3
6
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
13
21
6.72
5.54
1.4
1.5
—
—
—
0
0
36
204
2.04
3.10
5.9
3.6
314.96
85.07
ng/l
0.47
27
167
11
31
3.77
3.07
1.4
1.4
72.80
15.58
u/ml
—
5
6
65
470
1.73
2.54
3.8
2.9
—
—
estimate
—
0
0
75
576
1.67
2.26
8.1
7.2
1.20
1.20
mmol/l
0.09
63
493
44
299
1.70
2.08
2.7
2.1
5.50
2.87
mg/l
1.65
39
252
15
70
2.28
2.07
5.1
3.1
2.67
2.33
mmol/l
—
10
54
47
328
1.66
2.00
4.1
3.7
0.00
0.00
estimate
-0.00
18
106
20
110
1.96
1.85
3.1
3.8
2.95
2.13
mmol/l
0.30
15
89
6
18
3.44
1.76
2.2
1.5
21.08
15.62
ug/l
—
6
18
18
98
1.96
1.71
1.6
3.0
64.48
66.87
g/l
0.63
18
88
15
77
2.07
1.67
1.3
1.5
—
—
—
0
0
20
115
1.87
1.63
3.3
3.8
5.93
5.70
kpa
0.27
20
108
71
568
1.52
1.62
4.5
3.8
0.00
0.00
estimate
-0.00
20
120
53
399
1.54
1.59
4.9
3.2
—
—
—
0
0
20
116
1.85
1.59
4.1
3.6
—
—
—
0
0
72
580
1.51
1.58
4.7
3.8
0.00
2.69
estimate
0.50
19
113
43
312
1.55
1.51
4.8
3.0
1.11
0.32
e6/l
0.37
34
225
24
150
1.73
1.51
2.4
1.8
—
—
—
0
0
71
576
1.49
1.47
4.7
3.8
0.00
0.00
estimate
-0.00
19
124
6
22
2.80
1.45
1.0
1.8
—
—
—
0
0
24
153
1.69
1.41
9.1
9.1
10.26
11.79
kpa
1.21
24
147
24
153
1.69
1.41
9.1
9.0
5.15
5.20
kpa
0.07
24
147
81
933
0.67
1.40
5.2
5.2
2.01
1.94
mu/l
0.14
73
843
37
264
1.55
1.39
3.5
2.3
—
—
—
0
0
44
327
1.51
1.38
4.4
3.4
0.00
0.33
estimate
0.65
15
93
5
17
3.01
1.37
1.4
1.0
—
—
—
0
0
30
419
0.64
1.37
2.2
1.9
1.22
1.31
mmol/l
0.44
24
337
22
141
1.67
1.27
7.8
6.1
1.03
1.03
mmol/l
0.00
22
130
70
578
1.43
1.26
8.5
6.8
10.60
12.37
umol/l
1.05
70
553
86
970
0.69
1.22
7.0
6.6
40.25
39.39
mmol/mol
0.42
79
899
13
72
1.89
1.20
10.0
6.5
24.42
24.89
mmol/l
0.12
13
72
25
169
1.59
1.18
4.7
2.9
1.27
1.47
e6/l
0.11
15
86
57
458
1.42
1.17
3.1
2.5
78.30
77.97
nmol/l
0.03
51
408
30
212
1.53
1.17
2.7
1.8
—
—
—
0
0
8
40
2.06
1.14
2.6
3.3
—
—
—
0
0
5
21
2.43
1.10
1.2
1.6
—
—
—
0
0
5
21
2.43
1.10
1.2
1.6
—
—
—
0
0
90
998
0.71
1.05
5.0
5.5
5.95
5.93
mmol/l
0.07
82
909
7
35
2.05
1.01
1.4
1.3
—
—
—
0
0
9
51
1.82
0.96
1.1
2.8
2.70
3.02
g/l
—
9
44
12
72
1.73
0.88
1.9
1.7
—
—
—
0
0
57
483
1.31
0.78
5.7
4.0
40.53
47.68
ng/l
0.23
47
378
11
67
1.70
0.78
2.4
2.6
1.46
1.29
%
0.30
11
67
9
53
1.75
0.77
1.1
2.7
6.77
7.44
g/l
—
9
46
9
53
1.75
0.77
1.1
2.7
3.26
3.58
g/l
—
9
46
9
53
1.75
0.77
1.1
2.7
4.21
4.33
g/l
—
9
46
20
143
1.47
0.75
2.6
1.8
—
—
—
0
0
72
633
1.29
0.74
13.6
9.7
5.28
4.19
e9/l
1.82
65
548
9
57
1.62
0.73
1.2
1.4
—
—
—
0
0
5
26
1.96
0.71
1.4
1.5
—
—
—
0
0
26
199
1.38
0.69
4.0
3.3
0.77
0.81
mmol/l
1.12
26
190
5
27
1.88
0.69
1.8
1.3
—
—
—
0
0
60
523
1.26
0.64
7.7
6.5
1.20
1.21
mmol/l
0.75
55
474
30
242
1.31
0.58
1.8
1.9
388.50
460.30
pmol/l
0.50
22
204
12
82
1.51
0.56
11.0
8.1
93.01
94.20
%
0.42
12
82
10
66
1.56
0.54
2.0
2.6
0.64
0.63
%
—
10
66
70
769
0.82
0.53
3.7
4.2
15.46
14.95
pmol/l
0.80
62
695
23
181
1.33
0.52
4.3
2.8
0.26
0.95
e6/l
1.71
13
98
19
145
1.36
0.52
2.1
4.9
2.98
40.06
ug/l
0.72
19
124
51
446
1.23
0.51
4.7
3.8
0.00
0.05
estimate
0.78
18
100
18
137
1.36
0.50
3.9
3.7
254.50
243.53
u/l
0.27
18
129
96
1018
0.81
0.49
5.7
6.0
2.42
2.58
mmol/l
0.85
89
930
7
47
1.52
0.48
1.0
2.9
10.16
10.36
g/l
—
7
39
7
51
1.39
0.45
3.3
1.6
—
—
—
0
0
94
993
0.83
0.42
5.4
5.3
4.23
4.47
mmol/l
1.32
87
910
0
19
0.00
0.39
0.0
1.2
—
0.52
—
0
13
54
487
1.18
0.38
3.8
2.9
109.72
123.77
ug/l
0.21
49
447
92
970
0.84
0.37
27.7
17.0
77.23
76.46
ml/min/173m2
0.11
86
903
9
124
0.71
0.37
1.7
1.5
—
—
—
0
0
39
344
1.19
0.35
2.3
1.8
16.54
21.37
nmol/l
1.04
30
282
94
987
0.85
0.35
5.2
5.3
1.35
1.45
mmol/l
1.35
86
898
6
47
1.29
0.32
1.2
3.0
0.57
0.16
g/l
—
6
38
25
213
1.21
0.32
2.0
1.8
1086.08
1202.11
nmol/l
0.29
19
162
7
52
1.36
0.32
3.4
1.7
—
—
—
0
0
20
233
0.83
0.26
1.3
1.2
0.30
2.07
u/ml
—
5
60
5
40
1.26
0.22
1.0
3.2
0.00
0.00
g/l
—
5
35
5
41
1.23
0.22
1.6
1.3
—
0.01
—
0
8
41
377
1.13
0.21
4.6
3.8
16.39
7.33
mg/mmol
0.63
28
231
92
953
0.89
0.20
4.6
4.5
1.26
1.22
mmol/l
0.23
85
863
12
138
0.86
0.13
1.6
1.6
—
—
—
0
0
46
482
0.93
0.11
4.4
5.6
2.52
3.15
ug/l
0.29
40
420
36
379
0.93
0.09
4.1
4.6
25.03
22.23
%
0.35
14
207
48
496
0.95
0.07
2.7
2.2
96.79
96.90
pmol/l
0.00
34
255
81
797
1.04
0.05
36.4
21.8
14.82
13.81
%
3.22
81
789
57
562
1.02
0.01
3.1
2.8
—
—
—
0
0
11
111
0.99
0.00
1.1
1.3
—
—
—
0
0
18
181
0.99
0.00
1.3
1.3
15.98
35.15
iu/ml
—
5
55
28
279
1.00
0.00
2.5
3.3
0.93
0.81
ug/l
0.21
18
198
80
798
1.01
0.00
7.4
4.4
15.35
13.87
mm/h
0.30
74
735
13
135
0.96
0.00
15.3
7.7
—
—
—
0
0
0
6
0.00
0.00
0.0
3.2
—
10.05
—
0
6
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
3.2
—
4.72
—
0
6
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
12.17
—
0
6
0
8
0.00
0.00
0.0
1.9
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
56.22
—
0
5
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
995.40
—
0
5
0
5
0.00
-0.00
0.0
1.4
—
13.40
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
1880.20
—
0
5
16
160
1.00
-0.00
1.3
1.4
25.78
6.10
u/ml
—
6
49
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.6
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint I9_THROMBANG and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_THROMBANG | 2.288 [1.72, 3.04] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.357 |
During the follow-up period (1.1.1998 — 31.12.2019), 81 out of 256 females with I9_THROMBANG died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_THROMBANG | 1.982 [1.58, 2.48] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 146 out of 390 males with I9_THROMBANG died.
Mortality risk
Mortality risk for people of age
years, who have I9_THROMBANG.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.265% | 0.289% |
| 5 | 1.479% | 2.21% |
| 10 | 3.389% | 5.427% |
| 15 | 6.828% | 9.841% |
| 20 | 11.912% | 16.326% |
Relationships between endpoints
↥Index endpoint: I9_THROMBANG – Thromboangiitis obliterans
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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