intracranial embolism: Blocking of a blood vessel in the skull by an embolus which can be a blood clot (thrombus) or other undissolved material in the blood stream. Most emboli are of cardiac origin and are associated with heart diseases. Other non-cardiac sources of emboli are usually associated with vascular diseases.
Occlusion and stenosis of arteries, not leading to stroke
DOID EFO Endpoint Browser PheWeb
I9_STENOSIS
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
662 |
4. Check minimum number of eventsNone |
662 |
5. Include endpointsNone |
662 |
6. Filter based on genotype QC (FinnGen only) |
561 |
Control definitions (FinnGen only)
- Control exclude
- I9_CEREBVASC
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- I60-I69
- Name in latin
- Occlusio sive stenosis arteriarum cerebralium sine infarctu
Similar endpoints
↥List of similar endpoints to
Occlusion and stenosis of arteries, not leading to stroke
based on the number of shared cases.
Similar with more cases:
- Cerebrovascular diseases (FINNGEN)
- Cerebrovascular diseases
- Neurological diseases, wide definition
- Cardiovascular diseases (excluding rheumatic etc)
- Cardiovascular diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 7018 | 2849 | 3990 |
| Only index persons | 3710 | 1691 | 2019 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.10 | 0.08 | 0.11 |
| Only index persons | 0.07 | 0.06 | 0.08 |
| Median age at first event (years) | |||
| Whole population | 67.81 | 70.75 | 65.76 |
| Only index persons | 65.92 | 68.76 | 63.54 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 561 | 186 | 375 |
| Unadjusted period prevalence (%) | 0.14 | 0.07 | 0.17 |
| Median age at first event (years) | 63.53 | 64.11 | 63.25 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 583
- Matched controls
- 5830
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
268.4
307.7
184
10
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
133.8
307.7
164
17
4331X
ICD-9 Finland
Occlusion and stenosis of precerebral arteries, Carotid artery[OCCL/STENOSIS ARTERIAE CAROTIS SINE INFARCTU CEREBR]
+∞
240.8
214
*
5541
FHL
Subclavia and / or carotid endarterectomy, reconstruction or bypass surgery
847.0
140.0
132
*
I66.9
ICD-10 Finland
Occlusion and stenosis of unspecified cerebral artery
+∞
123.4
114
*
B01AC07
ATC
dipyridamole; systemic
10.0
122.3
165
222
B01AC30
ATC
platelet aggregation inhibitors excl. heparin - combinations
11.8
105.0
118
123
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
7.0
73.9
129
226
I63.3
ICD-10 Finland
Cerebral infarction due to thrombosis of cerebral arteries
804.5
73.9
71
*
I65.2
ICD-10 Finland
Occlusion and stenosis of carotid artery
804.5
73.9
71
*
K90
ICPC
Stroke/cerebrovascular accident
30.9
64.7
43
15
I66.0
ICD-10 Finland
Occlusion and stenosis of middle cerebral artery
+∞
56.2
53
*
G46.0*I66.0
ICD-10 Finland
Middle cerebral artery syndrome
+∞
55.1
52
*
I63.4
ICD-10 Finland
Cerebral infarction due to embolism of cerebral arteries
+∞
44.3
42
*
B01AC04
ATC
clopidogrel; oral
3.7
42.8
177
613
I70.9
ICD-10 Finland
Generalized and unspecified atherosclerosis
9.1
42.2
54
65
PA7AD
NOMESCO Finland
CT angiography of head and neck vasculature
9.8
40.0
48
53
I63.0
ICD-10 Finland
Cerebral infarction due to thrombosis of precerebral arteries
+∞
39.0
37
*
PAF14
NOMESCO Finland
Thrombendarterectomy of internal carotid artery
+∞
39.0
37
*
G45.0
ICD-10 Finland
Vertebro-basilar artery syndrome
8.5
35.9
48
61
4340A
ICD-9 Finland
Occlusion of cerebral arteries, Cerebral thrombosis
+∞
35.8
34
*
4351A
ICD-9 Finland
Transient cerebral ischaemia, Vertebral artery syndrome
53.5
33.9
40
8
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
3.5
33.8
142
490
G46.2*I66.2
ICD-10 Finland
Posterior cerebral artery syndrome
+∞
32.6
31
*
4331A
ICD-9 Finland
Occlusion and stenosis of precerebral arteries, Carotid artery[OCCL/STENOSIS ARTERIAE CAROTIS CUM INFARCTU CEREBRI]
+∞
32.6
31
*
4402A
ICD-9 Finland
Atherosclerosis, Of native arteries of the extremities
7.7
31.8
46
64
XA800
NOMESCO Finland
Neuropsychological investigation
9.4
31.0
38
43
G45.1
ICD-10 Finland
Carotid artery syndrome (hemispheric)
7.3
30.1
46
68
I66.8
ICD-10 Finland
Occlusion and stenosis of other cerebral artery
+∞
28.4
27
*
I66.3
ICD-10 Finland
Occlusion and stenosis of cerebellar arteries
+∞
26.2
25
*
AA1AD
NOMESCO Finland
CT of head and brain
2.6
25.6
213
1054
I63.5
ICD-10 Finland
Cerebral infarction due to unspecified occlusion or stenosis of cerebral arteries
+∞
24.1
23
*
PA6AD
NOMESCO Finland
CT of neck arteries
7.4
23.6
35
50
4339X
ICD-9 Finland
Occlusion and stenosis of precerebral arteries, Unspecified precerebral artery[OCCL/STENOSIS ARTER.PRAECEREBRALES NUD SINE INFARCT]
+∞
22.0
21
*
205
Kela drug reimbursment
Chronic hypertension
2.3
21.1
252
1443
4380A
ICD-9 Finland
Late effects of cerebrovascular disease[SEQUELAE MORBI CEREBROVASCULARIS]
+∞
21.0
20
*
PEF23
NOMESCO Finland
Thrombendarterectomy of femoral artery
7.7
21.0
30
41
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.8
20.0
65
186
I63.1
ICD-10 Finland
Cerebral infarction due to embolism of precerebral arteries
+∞
19.9
19
*
I66.2
ICD-10 Finland
Occlusion and stenosis of posterior cerebral artery
+∞
18.8
18
*
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
6.7
18.5
30
47
B01AA03
ATC
warfarin; systemic
2.2
17.9
207
1152
4019X
ICD-9 Finland
Essential hypertension, Unspecified
4.0
17.2
52
141
AA5BD
NOMESCO Finland
CT of cerebral ischaemia
22.7
17.0
24
11
206
Kela drug reimbursment
Chronic coronary artery disease and dyslipidaemia associated with chronic coronary artery disease
2.2
16.9
212
1215
I63.2
ICD-10 Finland
Cerebral infarction due to unspecified occlusion or stenosis of precerebral arteries
+∞
16.7
16
*
C08DB01
ATC
diltiazem; oral
3.0
16.6
79
287
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
4.7
16.6
39
87
C10AX09
ATC
ezetimibe; oral
2.5
15.8
110
488
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
2.1
15.6
233
1416
C10AA01
ATC
simvastatin; oral
2.0
15.6
312
2109
C10AA05
ATC
atorvastatin; oral
2.0
15.4
258
1635
I25.0
ICD-10 Finland
Atherosclerotic cardiovascular disease, so described
2.8
14.7
78
300
I66.1
ICD-10 Finland
Occlusion and stenosis of anterior cerebral artery
+∞
14.6
14
*
PA2VT
NOMESCO Finland
Intravascular evacuation of brain artery embolus
+∞
14.6
14
*
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
4.0
14.3
41
107
R42
ICD-10 Finland
Dizziness and giddiness
2.1
14.2
163
892
B04AB02, ,
ATC
4.4
14.1
36
86
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
2.3
14.0
127
631
C02DE04, ,
ATC
3.5
13.7
48
144
I66.4
ICD-10 Finland
Occlusion and stenosis of multiple and bilateral cerebral arteries
+∞
13.6
13
*
I60.9
ICD-10 Finland
Subarachnoid haemorrhage, unspecified
+∞
13.6
13
*
4330X
ICD-9 Finland
Occlusion and stenosis of precerebral arteries, Basilar artery[OCCL/STENOS ART.VERTEBRAL.SEU BASILAR.SINE INFARCTU]
+∞
13.6
13
*
I63.8
ICD-10 Finland
Other cerebral infarction
+∞
13.6
13
*
B04AB01, ,
ATC
5.2
13.5
28
56
C09AA02
ATC
enalapril; systemic
2.1
13.4
167
940
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
3.4
13.3
50
157
5314
FHL
Bypass surgery for four or more vessels
6.1
13.1
23
39
I61.9
ICD-10 Finland
Intracerebral haemorrhage, unspecified
+∞
12.5
12
*
213
Kela drug reimbursment
Fat metabolism disorder associated with chronic coronary artery disease
2.4
12.4
92
418
C08CA01
ATC
amlodipine; oral
1.9
12.3
257
1720
I25.1
ICD-10 Finland
Atherosclerotic heart disease
1.9
12.3
221
1409
AA5PD
NOMESCO Finland
CT examination of brain pefusion
38.4
12.3
15
*
G45.3
ICD-10 Finland
Amaurosis fugax
6.0
11.9
21
36
41399
ICD-8 Finland
Angina pectoris, Without mention of hypertensive disease
4.9
11.8
26
55
11
HP
Coronary artery bypass surgery
3.6
11.7
39
113
I67.2
ICD-10 Finland
Cerebral atherosclerosis
66.3
11.6
13
*
315
Kela drug reimbursment
Clopidogrel
11.4
11.6
21
19
PAN14
NOMESCO Finland
Plastic repair of arteries internal carotid artery
+∞
11.5
11
*
Z95.1
ICD-10 Finland
Presence of aortocoronary bypass graft
2.9
11.5
55
200
5651
FHL
Reoperation due to wound complication
122.3
11.5
12
*
I67.1
ICD-10 Finland
Cerebral aneurysm, nonruptured
122.3
11.5
12
*
I20.81
ICD-10 Finland
Other angina pectoris stenosed coronary artery
2.4
11.2
87
402
4350A
ICD-9 Finland
Transient cerebral ischaemia, Basilar artery syndrome
25.6
11.2
15
6
4409X
ICD-9 Finland
Atherosclerosis, Generalised and unspecified atherosclerosis
25.6
11.2
15
6
Z2445
NOMESCO Finland
Psychologist
5.7
10.8
20
36
H53.4
ICD-10 Finland
Visual field defects
9.4
10.6
21
23
5253
FHL
Cardiac lung machine
5.6
10.5
20
37
I65.3
ICD-10 Finland
Occlusion and stenosis of multiple and bilateral precerebral arteries
+∞
10.4
10
*
AAL10
NOMESCO Finland
Intracranial endovascular thrombolysis
+∞
10.4
10
*
C01DA14
ATC
isosorbide mononitrate; oral
1.9
10.1
176
1098
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
3.1
10.0
43
147
SPAT1251
SPAT
Organisation of medication
3.3
9.9
37
116
4130X
ICD-9 Finland
Angina pectoris, Angina decubitus[ANGINA PECTORIS (""""EFFORT ANGINA""""),MÄÄRITTELEMÄT]
3.3
9.8
38
122
B01AC06
ATC
acetylsalicylic acid; oral
2.6
9.8
57
230
C02DE02, ,
ATC
3.8
9.5
29
79
I69.1
ICD-10 Finland
Sequelae of intracerebral haemorrhage
101.6
9.4
10
*
G46.1*I66.1
ICD-10 Finland
Anterior cerebral artery syndrome
+∞
9.4
9
*
R51.80
ICD-10 Finland
Headache
2.4
9.3
68
305
N18
ICPC
Paralysis/weakness
9.7
9.3
18
19
C10AA03
ATC
pravastatin; oral
2.6
9.3
58
242
81
HP
Angiography of the heart and coronary arteries
2.3
9.3
74
346
C08CA05
ATC
nifedipine; systemic
2.5
9.1
62
270
TPX22
NOMESCO Finland
Intravenous arterial thrombolysis
37.3
9.0
11
*
C03CA01
ATC
furosemide; systemic
1.7
9.0
285
2098
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.7
8.9
213
1452
K89
ICPC
Transient cerebral ischaemia
10.9
8.8
16
15
R47.0
ICD-10 Finland
Dysphasia and aphasia
10.9
8.8
16
15
SPAT1252
SPAT
Overall medication plan or its review
2.4
8.6
59
258
I67.9
ICD-10 Finland
Cerebrovascular disease, unspecified
20.4
8.5
12
6
4120X
ICD-9 Finland
Old myocardial infarction[STATUS POST INFARCTUM CORDIS,MÄÄRITTELEMÄT]
3.6
8.5
28
81
N03AF02
ATC
oxcarbazepine; oral
4.4
8.5
21
49
A10AB05
ATC
insulin aspart; parenteral
2.5
8.4
53
222
E78.5
ICD-10 Finland
Hyperlipidaemia, unspecified
2.3
8.4
70
333
4341A
ICD-9 Finland
Occlusion of cerebral arteries, Cerebral embolism
+∞
8.4
8
*
I61.0
ICD-10 Finland
Intracerebral haemorrhage in hemisphere, subcortical
+∞
8.4
8
*
I69.0
ICD-10 Finland
Sequelae of subarachnoid haemorrhage
+∞
8.4
8
*
E78.00
ICD-10 Finland
Familial hypercholesterolaemia
3.1
8.2
34
114
4120B
ICD-9 Finland
Old myocardial infarction[STATUS POST INFARCTUM CORDIS,AHTAUTUNUT]
4.2
8.1
21
51
C07AB03
ATC
atenolol; systemic
2.4
8.0
58
260
R4130
NOMESCO Finland
Speech therapy
4.5
7.5
18
41
I48
ICD-10 Finland
Atrial fibrillation and flutter
1.7
7.5
195
1347
I20.00
ICD-10 Finland
Unstable angina
2.9
7.5
35
126
PA2BC
NOMESCO Finland
Cerebral extensive angiography with X-ray
81.1
7.4
8
*
5315
FHL
Bypass surgery using a mammary artery
3.8
7.4
22
59
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
1.8
7.3
143
912
AAC00
NOMESCO Finland
Ligature of intracranial aneurysm
+∞
7.3
7
*
4349A
ICD-9 Finland
Occlusion of cerebral arteries, Cerebral artery occlusion, unspecified[OCCL/STENOS ARTER.CEREBRALES NUD CUM INFARCTU CEREB]
+∞
7.3
7
*
I63
ICD-10 Finland
Cerebral infarction
+∞
7.3
7
*
A06AD11
ATC
lactulose; oral
1.8
7.3
134
840
C02LM02, ,
ATC
4.6
7.2
17
38
I20.90
ICD-10 Finland
Angina pectoris, unspecified
2.6
7.2
40
158
K91
ICPC
Cerebrovascular disease
12.2
7.1
12
10
F01.9
ICD-10 Finland
Vascular dementia, unspecified
3.6
6.8
22
63
N06AB04
ATC
citalopram; systemic
1.8
6.8
112
679
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.9
6.7
32
116
C10AA02
ATC
lovastatin; oral
2.6
6.7
39
158
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.8
6.5
107
648
XF400
NOMESCO Finland
ECG with 12 standard connections
1.8
6.5
104
625
R1250
NOMESCO Finland
Evaluation of functional capability
3.8
6.4
19
51
N02AX02
ATC
tramadol; systemic, rectal
1.6
6.3
237
1773
G81.9
ICD-10 Finland
Hemiplegia, unspecified
11.2
6.3
11
10
G46.0
ICD-10 Finland
Middle cerebral artery syndrome
+∞
6.3
6
*
G46.4*I67.9
ICD-10 Finland
Cerebellar stroke syndrome
+∞
6.3
6
*
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
2.0
6.3
70
373
C07AA07
ATC
sotalol; systemic
2.4
6.2
42
182
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
2.2
6.2
50
234
I10
ICD-10 Finland
Essential (primary) hypertension
1.6
6.2
360
2963
Z01.8
ICD-10 Finland
Other specified special examinations
1.8
6.2
111
689
I70.8
ICD-10 Finland
Atherosclerosis of other arteries
12.7
6.1
10
8
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
136
585
2.73
21.18
2.1
1.9
30.11
29.79
s
0.11
136
560
191
1208
1.86
10.56
2.9
2.0
130.51
316.90
u/l
2.04
185
1116
64
315
2.16
7.06
3.0
2.9
122.78
126.34
g/l
0.59
64
304
11
16
6.98
4.97
1.7
1.1
2.38
2.09
mmol/l
0.40
11
16
279
2247
1.46
4.85
26.1
19.2
1.47
1.38
inr
1.39
246
1902
305
3520
0.72
3.73
27.4
18.9
71.06
70.93
ml/min/173m2
0.03
289
3293
312
3566
0.73
3.43
5.9
5.4
6.25
6.10
mmol/l
1.06
294
3186
144
1843
0.71
3.16
5.2
6.4
3.43
3.57
ug/l
0.04
131
1607
74
1069
0.65
3.07
2.5
3.6
0.89
0.85
ug/l
0.12
49
755
359
3986
0.74
3.01
39.0
28.6
130.13
131.53
g/l
0.93
351
3914
359
3985
0.74
3.00
40.2
28.7
38.77
39.26
%
0.69
350
3910
359
3985
0.74
3.00
38.7
28.3
4.35
4.36
e12/l
0.10
349
3866
359
3984
0.74
2.99
38.7
28.4
238.44
235.84
e9/l
0.31
349
3882
73
490
1.56
2.97
3.9
3.3
1.81
1.94
mmol/l
0.12
65
406
359
3982
0.74
2.96
38.7
28.3
91.56
91.84
fl
0.52
350
3911
347
3857
0.75
2.82
14.1
12.0
26.68
24.57
u/l
0.46
335
3704
25
124
2.06
2.80
3.2
3.0
7.09
7.50
mmol/l
0.30
25
118
319
3575
0.76
2.67
7.2
5.9
2.23
2.52
mmol/l
8.00
304
3199
27
141
1.96
2.65
3.1
3.1
1.60
1.63
mmol/l
0.04
27
134
82
583
1.47
2.57
10.2
5.8
1.01
1.28
mmol/l
0.22
68
467
115
1482
0.72
2.54
4.7
5.1
22.50
22.27
%
0.06
62
805
359
3949
0.76
2.53
35.4
25.6
88.39
87.95
umol/l
0.07
348
3882
117
894
1.39
2.47
6.2
4.1
144.35
301.75
ng/l
1.27
97
781
8
22
3.67
2.37
1.0
1.0
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
26
140
1.90
2.36
2.8
2.3
0.42
0.35
iu/ml
0.56
13
81
314
3486
0.78
2.21
6.3
5.1
4.08
4.39
mmol/l
6.59
299
3136
53
357
1.53
2.16
1.8
1.6
—
—
—
0
0
311
3447
0.79
2.10
6.2
5.1
1.34
1.43
mmol/l
3.98
296
3073
60
421
1.47
2.03
3.2
2.6
7.02
6.73
ug/l
0.04
53
364
59
415
1.47
1.98
3.8
3.5
262.56
281.67
ng/l
0.09
52
380
32
502
0.62
1.93
6.5
5.1
32.41
32.93
%
0.09
22
308
216
1859
1.26
1.90
3.0
2.9
—
—
estimate
—
0
0
359
3891
0.80
1.87
34.3
23.2
139.63
139.58
mmol/l
0.10
347
3799
8
28
2.88
1.87
1.3
1.1
—
—
—
0
0
360
3893
0.80
1.79
34.6
23.4
4.03
4.02
mmol/l
0.15
347
3798
319
3489
0.81
1.74
8.1
7.0
42.28
40.50
mmol/mol
2.46
300
3181
163
1379
1.25
1.63
3.4
2.4
63.88
60.93
u/l
0.11
158
1269
5
14
3.59
1.62
1.6
1.1
—
—
—
0
0
7
26
2.71
1.58
1.3
1.1
—
—
—
0
0
349
3764
0.82
1.57
28.1
18.9
27.44
28.40
mg/l
0.23
314
3211
5
15
3.35
1.52
1.0
1.1
—
1.03
—
0
9
49
356
1.41
1.43
4.9
3.5
114.90
97.44
ng/l
0.41
41
312
262
2886
0.83
1.40
5.0
4.1
14.19
15.29
mm/h
0.54
252
2625
145
1231
1.24
1.40
3.4
3.0
33.53
35.80
u/l
0.30
135
1164
37
259
1.46
1.33
1.7
1.4
—
—
—
0
0
136
1155
1.23
1.31
4.5
4.0
0.00
0.11
estimate
0.85
39
359
176
2001
0.83
1.31
2.5
2.3
98.07
95.57
pmol/l
0.30
108
1065
304
3292
0.84
1.30
5.4
4.3
1.40
1.24
mmol/l
2.96
289
2903
103
848
1.26
1.30
1.7
1.6
1.42
1.62
mg/l
0.26
83
679
314
3388
0.84
1.28
5.9
5.0
1.96
2.04
mu/l
0.51
297
3021
132
1540
0.82
1.27
3.0
3.3
2.33
2.35
mmol/l
0.63
118
1371
9
44
2.06
1.27
2.1
1.1
—
—
—
0
0
77
955
0.78
1.27
2.6
3.1
2.46
2.46
mmol/l
0.06
67
837
6
25
2.41
1.24
1.3
1.1
—
—
—
0
0
210
1869
1.19
1.24
7.6
4.4
68.67
103.22
ng/l
0.37
174
1490
26
172
1.54
1.22
3.3
3.2
4.22
4.31
pmol/l
0.16
26
150
6
26
2.32
1.19
1.0
1.1
—
—
—
0
0
121
1412
0.82
1.16
1.9
1.8
17.38
19.92
nmol/l
1.58
114
1173
0
33
0.00
1.16
0.0
1.2
—
—
—
0
0
39
287
1.38
1.10
4.2
4.1
2.86
2.27
mmol/l
0.32
32
220
18
112
1.63
1.10
1.2
1.6
—
—
—
0
0
9
46
1.97
1.04
2.0
1.7
—
—
—
0
0
13
75
1.75
1.03
1.3
1.2
—
—
—
0
0
11
60
1.85
1.03
1.1
1.6
—
—
—
0
0
12
68
1.78
1.01
2.8
6.0
—
160.38
iu/ml
—
0
8
63
776
0.79
1.00
4.1
3.3
7.14
1.02
e6/l
0.52
36
437
57
452
1.29
1.00
5.1
6.3
11.72
12.32
mmol/l
0.18
57
428
256
2773
0.86
1.00
4.8
3.9
15.26
15.05
pmol/l
0.59
237
2457
0
30
0.00
0.97
0.0
1.2
—
—
—
0
0
136
1542
0.85
0.95
4.5
3.7
74.60
94.14
e6/l
0.18
110
1234
5
102
0.49
0.90
1.6
1.3
—
—
—
0
0
113
980
1.19
0.89
1.8
1.8
1149.22
1171.18
nmol/l
0.10
87
730
6
30
2.01
0.87
1.0
1.2
106.17
88.33
pmol/l
—
6
30
18
120
1.52
0.86
1.3
1.3
—
—
—
0
0
8
44
1.83
0.86
1.1
1.7
—
—
—
0
0
115
1310
0.85
0.85
4.5
3.6
0.63
0.46
e6/l
0.26
92
1015
273
2921
0.88
0.84
33.6
24.7
330.10
330.86
g/l
0.64
268
2895
61
738
0.81
0.84
4.2
3.4
4.31
2.16
e6/l
0.46
35
399
6
32
1.88
0.82
1.0
1.3
—
—
—
0
0
6
32
1.88
0.82
1.0
1.3
—
—
—
0
0
118
1037
1.17
0.80
2.0
1.8
393.08
20616552.06
pmol/l
0.74
104
844
22
156
1.43
0.80
6.0
3.2
1.82
2.86
ratio
0.64
13
86
0
24
0.00
0.79
0.0
1.3
—
—
—
0
0
0
26
0.00
0.78
0.0
1.3
—
—
—
0
0
0
26
0.00
0.78
0.0
1.3
—
—
—
0
0
0
26
0.00
0.78
0.0
1.3
—
—
—
0
0
6
34
1.77
0.76
4.3
1.6
312.00
696.03
mg
—
6
34
248
2306
1.13
0.76
9.5
6.5
1.20
1.21
mmol/l
0.63
227
1935
10
59
1.71
0.76
1.3
1.3
—
—
—
0
0
150
1658
0.87
0.74
4.4
3.6
—
—
—
0
0
7
38
1.85
0.73
2.3
2.5
535.86
597.71
ml
—
7
24
293
3103
0.89
0.73
8.9
7.9
92.02
83.32
u/l
0.88
283
2907
7
39
1.80
0.72
1.1
1.3
—
—
—
0
0
23
168
1.38
0.72
1.1
1.2
294.63
139.12
u/ml
—
8
59
124
1386
0.87
0.72
2.2
1.9
1.45
1.29
mmol/l
0.95
108
1112
24
319
0.74
0.71
1.4
1.5
—
—
—
0
0
5
26
1.93
0.70
1.0
1.6
—
—
—
0
0
138
1241
1.15
0.70
5.0
4.4
0.00
0.00
estimate
0.50
49
407
17
118
1.45
0.70
1.2
1.7
—
—
—
0
0
229
2130
1.12
0.69
5.1
4.3
0.00
7.21
estimate
0.80
54
486
5
27
1.86
0.68
3.4
2.4
—
—
—
0
0
226
2102
1.12
0.68
5.1
4.3
0.00
0.00
estimate
-0.00
54
462
5
28
1.79
0.66
1.2
1.1
—
—
—
0
0
5
28
1.79
0.66
1.0
1.6
—
—
—
0
0
40
490
0.80
0.65
10.0
9.0
—
—
—
0
0
5
29
1.73
0.64
1.2
1.2
—
—
—
0
0
0
20
0.00
0.60
0.0
1.8
—
38.00
—
0
20
8
52
1.55
0.59
4.1
4.3
—
—
—
0
0
15
106
1.43
0.58
1.3
1.3
—
—
—
0
0
15
106
1.43
0.58
1.3
1.3
—
—
—
0
0
22
285
0.76
0.57
1.3
1.5
—
—
—
0
0
5
89
0.56
0.56
1.6
1.6
42.20
44.09
nmol/l
—
5
82
6
37
1.63
0.55
1.5
1.4
—
68.00
—
0
5
9
60
1.51
0.54
1.1
1.3
—
56.18
—
0
11
124
1128
1.13
0.54
3.1
2.9
392.09
367.09
umol/l
1.20
108
957
166
1789
0.90
0.54
3.4
3.0
144.26
156.22
ug/l
0.30
158
1624
105
950
1.13
0.50
6.2
4.6
1.02
1.02
kg/l
0.27
76
638
174
1623
1.10
0.49
5.4
4.4
0.00
0.03
estimate
1.43
34
386
46
394
1.18
0.46
1.7
1.4
—
—
—
0
0
17
129
1.33
0.46
2.5
1.5
—
—
—
0
0
34
283
1.21
0.46
15.7
7.3
24.13
24.64
mmol/l
0.32
34
271
227
2150
1.09
0.46
5.2
4.4
0.00
0.66
estimate
0.50
54
453
155
1442
1.10
0.46
4.2
4.1
11.11
9.21
mg/mmol
0.22
106
953
50
433
1.17
0.45
2.2
2.2
0.21
0.20
g/l
0.42
43
395
12
86
1.40
0.45
1.1
1.0
—
8.99
—
0
10
7
51
1.38
0.44
1.1
1.3
—
—
—
0
0
11
78
1.42
0.43
1.2
1.2
—
0.92
—
0
5
26
316
0.81
0.43
1.7
2.8
58.90
55.98
ml/min/173m2
—
10
144
73
655
1.13
0.41
2.0
1.8
—
—
—
0
0
5
33
1.52
0.41
1.0
1.5
—
—
—
0
0
69
617
1.13
0.41
2.0
1.9
—
—
—
0
0
0
17
0.00
0.40
0.0
1.1
—
—
—
0
0
0
17
0.00
0.40
0.0
1.7
—
12.45
—
0
17
0
17
0.00
0.40
0.0
1.6
—
65.88
—
0
17
8
60
1.34
0.40
1.1
1.7
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
210
1995
1.08
0.39
5.5
4.8
33.76
34.50
g/l
0.94
201
1838
0
19
0.00
0.39
0.0
1.2
—
170.96
—
0
19
27
320
0.84
0.36
2.1
1.7
—
—
—
0
0
12
157
0.76
0.36
1.8
1.6
—
—
—
0
0
11
145
0.75
0.35
2.2
1.5
—
—
—
0
0
95
876
1.10
0.35
2.1
1.9
—
—
—
0
0
14
109
1.29
0.33
1.4
1.5
0.06
57.68
iu/ml
—
6
21
107
995
1.09
0.33
2.8
2.4
—
—
—
0
0
6
46
1.31
0.33
1.2
1.1
—
—
—
0
0
20
165
1.22
0.31
1.2
1.3
—
—
—
0
0
13
102
1.28
0.30
1.0
1.2
—
—
—
0
0
10
76
1.32
0.28
1.1
1.2
19.17
32.54
u/l
—
10
66
11
85
1.30
0.28
1.2
1.5
—
—
—
0
0
8
65
1.23
0.27
1.8
1.3
—
—
—
0
0
14
113
1.24
0.27
1.6
1.4
201.67
296.57
ug/g
—
6
72
12
95
1.27
0.26
1.2
1.5
—
—
—
0
0
5
71
0.70
0.26
1.0
1.6
168.40
232.08
pmol/l
—
5
64
12
148
0.81
0.24
1.8
2.9
13.97
39.64
u/ml
2.02
12
140
173
1801
0.94
0.24
2.8
2.6
—
—
—
0
0
5
42
1.19
0.21
2.0
4.6
356.20
322.83
umol/l
—
5
36
0
11
0.00
0.21
0.0
2.9
—
2.72
—
0
5
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
0
10
0.00
0.21
0.0
4.4
—
114.80
—
0
10
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
59.47
—
0
12
0
13
0.00
0.21
0.0
2.5
—
2172.77
—
0
13
6
49
1.23
0.20
3.8
1.9
2.70
0.99
mmol/l
—
6
49
216
2223
0.95
0.19
4.1
3.2
66.44
57.06
u/l
0.58
201
2045
11
90
1.23
0.19
1.2
1.2
—
—
—
0
0
29
261
1.12
0.18
1.8
1.7
1.84
1.53
g/l
1.04
23
234
60
563
1.07
0.17
1.4
1.3
22.84
33.88
iu/ml
0.65
14
183
46
494
0.93
0.16
5.1
4.0
—
—
—
0
0
8
72
1.11
0.16
1.1
1.7
—
—
—
0
0
10
83
1.21
0.15
1.1
1.8
—
—
—
0
0
12
102
1.18
0.15
1.0
1.2
—
—
—
0
0
7
88
0.79
0.14
1.0
1.6
—
—
—
0
0
20
179
1.12
0.14
1.6
1.4
—
36.19
—
0
12
22
199
1.11
0.13
2.1
3.0
—
—
—
0
0
74
707
1.05
0.13
1.3
1.2
0.67
1.41
u/ml
1.53
21
161
11
94
1.17
0.13
1.7
1.4
—
—
—
0
0
145
1410
1.04
0.12
3.6
3.4
7.16
7.27
mmol/l
0.12
124
1176
14
123
1.14
0.12
1.4
1.4
—
—
—
0
0
10
85
1.18
0.12
1.2
1.6
—
—
—
0
0
12
137
0.87
0.12
1.2
1.5
—
—
—
0
0
10
116
0.86
0.12
1.1
1.4
—
—
—
0
0
220
2241
0.97
0.11
8.1
8.5
4.51
4.35
e9/l
0.37
190
1937
12
105
1.15
0.11
1.7
1.4
24.57
29.44
g/l
0.69
12
97
171
1748
0.97
0.11
3.1
2.3
75.71
79.64
nmol/l
0.90
153
1528
210
2064
1.03
0.10
9.2
5.7
1.20
1.21
mmol/l
1.17
201
1869
6
58
1.03
0.08
1.7
1.5
—
—
—
0
0
5
60
0.83
0.08
1.0
1.3
—
—
—
0
0
9
85
1.06
0.07
2.0
3.6
6.41
11.40
pmol/l
—
9
85
16
149
1.08
0.05
1.0
1.0
—
—
—
0
0
127
1288
0.98
0.04
2.6
2.3
3.37
3.16
mg/l
0.24
113
1086
280
2780
1.01
0.04
6.0
5.3
10209.20
1621.46
e6/l
—
5
57
15
141
1.07
0.03
1.4
1.2
—
—
—
0
0
111
1122
0.99
0.02
3.3
2.9
6.00
4.75
e6/l
0.54
96
1020
10
93
1.08
0.02
1.4
2.1
4.35
3.68
g/l
—
10
87
170
1709
0.99
0.01
4.8
3.5
2767.46
2124.84
ng/l
0.59
156
1498
52
527
0.99
0.01
1.4
1.3
1.49
11.86
u/ml
2.67
18
183
10
98
1.02
0.00
1.1
1.9
11.64
13.37
mg/l
—
10
89
17
169
1.01
0.00
1.9
1.7
—
—
—
0
0
19
191
0.99
0.00
2.1
1.8
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
8.55
—
0
8
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
5
59
0.85
-0.00
1.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
58
0.86
-0.00
1.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
1.67
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
7
71
0.99
-0.00
2.7
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.6
—
109.94
—
0
5
0
9
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
1.16
—
0
5
5
57
0.88
-0.00
1.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
6.4
—
146.40
—
0
5
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
7
0.00
-0.00
0.0
1.9
—
127.14
—
0
7
6
67
0.89
-0.00
1.0
1.2
—
—
—
0
0
5
58
0.86
-0.00
1.0
1.3
—
—
—
0
0
6
62
0.97
-0.00
2.8
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint I9_STENOSIS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_STENOSIS | 1.749 [1.52, 2.02] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.296 |
During the follow-up period (1.1.1998 — 31.12.2019), 656 out of 1237 females with I9_STENOSIS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_STENOSIS | 1.811 [1.56, 2.1] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.008 |
During the follow-up period (1.1.1998 — 31.12.2019), 719 out of 1395 males with I9_STENOSIS died.
Mortality risk
Mortality risk for people of age
years, who have I9_STENOSIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.192% | 0.308% |
| 5 | 1.036% | 2.107% |
| 10 | 2.553% | 5.306% |
| 15 | 4.843% | 9.863% |
| 20 | 8.837% | 16.834% |
Relationships between endpoints
↥Index endpoint: I9_STENOSIS – Occlusion and stenosis of arteries, not leading to stroke
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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