brain aneurysm: A congenital or acquired aneurysm within the cranium.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
319 |
4. Check minimum number of eventsNone |
319 |
5. Include endpointsNone |
319 |
6. Filter based on genotype QC (FinnGen only) |
281 |
Control definitions (FinnGen only)
- Control exclude
- I9_CEREBVASC
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- I67
- Name in latin
- Dissectio arteriae cerebralis sine ruptura
Similar endpoints
↥List of similar endpoints to
Dissection of cerebral arteries, nonruptured
based on the number of shared cases.
Similar with more cases:
- Cerebrovascular diseases
- Neurological diseases, wide definition
- Cardiovascular diseases
- Any operation in hilmo
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1673 | 729 | 931 |
| Only index persons | 1553 | 683 | 870 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.03 |
| Only index persons | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 52.52 | 52.32 | 52.80 |
| Only index persons | 51.96 | 51.56 | 52.28 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 281 | 154 | 127 |
| Unadjusted period prevalence (%) | 0.06 | 0.05 | 0.06 |
| Median age at first event (years) | 50.85 | 47.98 | 54.34 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 296
- Matched controls
- 2960
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
I67.0
ICD-10 Finland
Dissection of cerebral arteries, nonruptured
+∞
307.7
295
*
B01AA03
ATC
warfarin; systemic
14.0
118.9
158
224
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
39.8
107.1
68
22
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
345.1
79.7
77
*
AA1AD
NOMESCO Finland
CT of head and brain
7.8
71.1
169
431
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
426.4
68.6
66
*
PA6AD
NOMESCO Finland
CT of neck arteries
19.4
59.5
49
30
I63.2
ICD-10 Finland
Cerebral infarction due to unspecified occlusion or stenosis of precerebral arteries
+∞
49.4
46
*
I67.1
ICD-10 Finland
Cerebral aneurysm, nonruptured
+∞
44.9
42
*
B01AC30
ATC
platelet aggregation inhibitors excl. heparin - combinations
15.3
42.5
39
29
I65.2
ICD-10 Finland
Occlusion and stenosis of carotid artery
+∞
41.7
39
*
XA800
NOMESCO Finland
Neuropsychological investigation
10.2
39.5
48
55
I63.3
ICD-10 Finland
Cerebral infarction due to thrombosis of cerebral arteries
404.0
36.8
36
*
G90.2
ICD-10 Finland
Horner syndrome
334.8
30.4
30
*
PA7AD
NOMESCO Finland
CT angiography of head and neck vasculature
10.6
30.3
35
37
B01AC04
ATC
clopidogrel; oral
5.0
29.2
75
187
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
7.5
29.0
45
69
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
5.1
24.2
58
135
AAC00
NOMESCO Finland
Ligature of intracranial aneurysm
+∞
22.2
21
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
4.9
21.3
53
127
R51.80
ICD-10 Finland
Headache
3.7
21.2
88
307
PA6BG
NOMESCO Finland
MRI examination of neck vasculature with high intensity magnet
83.0
21.0
23
*
I63.0
ICD-10 Finland
Cerebral infarction due to thrombosis of precerebral arteries
+∞
20.0
19
*
PA6CG
NOMESCO Finland
Extensive MRI examination of neck vasculature with high intensity magnet
213.7
19.8
20
*
K90
ICPC
Stroke/cerebrovascular accident
59.1
19.2
22
*
XF400
NOMESCO Finland
ECG with 12 standard connections
3.6
17.2
67
222
I67.9
ICD-10 Finland
Cerebrovascular disease, unspecified
37.5
16.9
21
6
PA2BG
NOMESCO Finland
MRI examination of vessels in the head with high intensity magnet
+∞
16.8
16
*
I65.0
ICD-10 Finland
Occlusion and stenosis of vertebral artery
+∞
16.8
16
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.6
16.8
64
209
PA2BC
NOMESCO Finland
Cerebral extensive angiography with X-ray
95.6
16.7
18
*
PA2CC
NOMESCO Finland
Cerebral very extensive angiography with X-ray
40.4
15.6
19
5
C10AA05
ATC
atorvastatin; oral
2.6
14.5
139
751
G45.0
ICD-10 Finland
Vertebro-basilar artery syndrome
15.7
13.8
22
15
B01AB05
ATC
enoxaparin; parenteral
2.5
13.0
115
592
R42
ICD-10 Finland
Dizziness and giddiness
2.8
12.9
82
358
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.8
12.5
42
125
PA2BD
NOMESCO Finland
Extensive CT angiography of brain
16.8
12.3
19
12
H53.1
ICD-10 Finland
Subjective visual disturbances
3.9
12.2
39
112
I72.0
ICD-10 Finland
Aneurysm and dissection of carotid artery
+∞
11.5
11
*
N03AF02
ATC
oxcarbazepine; oral
5.7
11.0
21
39
I69.0
ICD-10 Finland
Sequelae of subarachnoid haemorrhage
+∞
10.5
10
*
R4120
NOMESCO Finland
Occupational therapy
3.8
10.2
33
95
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
8.3
9.8
21
27
G45.1
ICD-10 Finland
Carotid artery syndrome (hemispheric)
8.9
9.7
20
24
PA7CC
NOMESCO Finland
Very extensive angiography of arteries of neck and brain
56.9
9.7
11
*
PA7BD
NOMESCO Finland
CT angiography of neck and brain
15.7
9.6
15
10
R4150
NOMESCO Finland
Neuropsychological rehabilitation
18.3
9.5
14
8
I60.9
ICD-10 Finland
Subarachnoid haemorrhage, unspecified
+∞
9.4
9
*
I69.1
ICD-10 Finland
Sequelae of intracerebral haemorrhage
+∞
9.4
9
*
I63.4
ICD-10 Finland
Cerebral infarction due to embolism of cerebral arteries
+∞
9.4
9
*
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
4.3
9.2
24
59
Z2445
NOMESCO Finland
Psychologist
4.4
9.1
23
55
TPH04
NOMESCO Finland
Cathetrisation of vein
2.4
9.1
78
387
AA1AG
NOMESCO Finland
Short MRI examination of brain with median intensity magnet
9.4
8.7
17
19
K99
ICPC
Cardiovascular disease other
9.9
8.4
16
17
G46.4*I67.9
ICD-10 Finland
Cerebellar stroke syndrome
+∞
8.4
8
*
PAF14
NOMESCO Finland
Thrombendarterectomy of internal carotid artery
+∞
8.4
8
*
I67.8
ICD-10 Finland
Other specified cerebrovascular diseases
+∞
8.4
8
*
R4110
NOMESCO Finland
Physiotherapy
2.1
7.9
95
539
C09AA05
ATC
ramipril; oral
2.2
7.8
77
403
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.0
7.8
143
944
ZXA05
NOMESCO Finland
Left side
2.2
7.7
77
405
H53.4
ICD-10 Finland
Visual field defects
11.3
7.4
13
12
I63.5
ICD-10 Finland
Cerebral infarction due to unspecified occlusion or stenosis of cerebral arteries
+∞
7.3
7
*
PA2AC
NOMESCO Finland
Cerebral angiography with X-ray
+∞
7.3
7
*
I63.1
ICD-10 Finland
Cerebral infarction due to embolism of precerebral arteries
+∞
7.3
7
*
PA6AG
NOMESCO Finland
Limited MRI examination of neck vasculature with high intensity magnet
30.8
7.2
9
*
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.4
7.2
53
244
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
5.7
7.0
19
35
ZXD10
NOMESCO Finland
Scheduled procedure
2.0
6.9
115
726
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
3.2
6.7
28
95
AA5BD
NOMESCO Finland
CT of cerebral ischaemia
23.1
6.7
9
*
I10
ICD-10 Finland
Essential (primary) hypertension
1.9
6.5
173
1267
Z2446
NOMESCO Finland
Social worker
3.1
6.5
27
92
XCK00
NOMESCO Finland
Perimetry
3.5
6.4
22
66
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.2
6.4
62
321
I63.8
ICD-10 Finland
Other cerebral infarction
+∞
6.3
6
*
R51
ICD-10 Finland
Headache
3.2
6.1
24
79
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
2.7
6.0
33
131
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
118
310
5.67
44.91
1.9
1.8
30.28
29.18
s
0.41
113
300
162
708
3.85
29.15
2.4
2.0
145.50
170.22
u/l
0.35
155
663
177
1061
2.66
15.02
18.8
11.0
1.48
1.18
inr
7.05
147
866
213
1431
2.74
13.82
7.0
4.6
6.14
6.59
mmol/l
5.33
202
1351
63
252
2.91
11.54
9.9
8.2
1.06
1.06
mmol/l
0.01
47
219
63
256
2.86
11.19
10.2
8.1
5.10
5.20
kpa
0.46
57
246
63
256
2.86
11.19
10.2
8.1
13.37
12.20
kpa
0.68
57
248
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
22
52
4.49
8.82
2.5
2.3
0.45
0.33
iu/ml
0.81
17
30
84
461
2.15
7.53
3.9
3.2
329.06
276.78
ng/l
0.11
58
333
12
9
13.83
7.45
1.6
2.2
—
—
—
0
0
38
149
2.78
7.11
11.1
10.1
0.72
0.67
%
0.28
38
149
154
1066
1.93
7.09
9.0
5.8
1.20
1.21
mmol/l
1.10
144
996
17
29
6.15
6.71
1.1
1.1
2.78
2.09
u/ml
—
9
11
75
413
2.09
6.58
3.2
2.7
1.44
0.90
e6/l
0.62
37
205
165
1195
1.86
6.36
9.8
6.6
1.20
1.21
mmol/l
1.25
145
1042
69
375
2.10
6.24
3.6
2.8
3.81
2.95
e6/l
0.15
31
170
16
29
5.77
6.08
1.1
1.2
1.20
1.20
u/ml
—
5
10
36
152
2.56
5.82
11.4
9.9
1.62
1.40
%
0.31
36
152
105
676
1.86
5.76
3.5
2.9
0.29
0.26
e6/l
0.08
73
476
61
331
2.06
5.50
10.0
6.6
105.49
104.16
mmol/l
1.48
61
331
18
55
3.42
5.11
1.6
1.1
38.67
23.31
e6/l
0.16
12
39
18
57
3.30
4.85
1.6
1.2
1589.77
186.71
e6/l
0.41
13
41
40
196
2.20
4.66
3.4
2.7
68.13
75.07
ml/min/173m2
0.33
15
82
32
143
2.39
4.60
11.3
7.4
24.84
25.21
mmol/l
0.21
32
143
30
132
2.42
4.46
10.0
6.6
24.28
24.74
mmol/l
0.33
25
127
87
573
1.73
4.23
2.2
2.0
2.81
2.94
mg/l
0.20
79
503
279
2550
2.64
3.93
20.7
13.5
22.49
23.08
mg/l
0.09
239
2049
28
127
2.33
3.91
13.9
9.7
15.74
16.19
%
0.32
23
122
13
35
3.84
3.64
1.1
1.1
—
—
—
0
0
121
906
1.57
3.43
3.7
3.5
37.02
40.61
ng/l
0.07
72
596
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
7
10
7.14
3.38
1.0
1.0
115.86
147.80
%
—
7
10
8
14
5.84
3.36
1.1
1.1
—
—
—
0
0
168
1358
1.55
3.36
4.0
3.4
0.08
5.51
estimate
0.49
24
295
85
588
1.63
3.35
3.0
2.2
—
—
—
0
0
78
530
1.64
3.30
1.4
1.3
34.83
29.69
iu/ml
0.18
25
163
18
72
2.60
3.28
1.7
1.8
8.09
10.28
g/l
1.47
18
67
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
7
11
6.49
3.20
1.1
1.4
—
—
—
0
0
83
579
1.60
3.14
4.3
3.6
1.02
1.02
kg/l
0.26
56
376
17
69
2.55
3.02
1.6
1.8
0.00
0.07
g/l
0.49
17
63
167
1371
1.50
2.95
4.0
3.5
0.00
1.09
estimate
0.50
22
277
164
1347
1.49
2.85
4.1
3.4
0.04
0.00
estimate
0.48
23
287
18
78
2.39
2.80
1.7
2.1
0.38
0.98
g/l
0.52
18
70
44
267
1.76
2.80
2.5
1.7
—
—
—
0
0
81
576
1.56
2.79
1.8
1.7
0.85
1.13
mg/l
0.64
59
454
45
277
1.74
2.73
2.3
1.7
—
—
—
0
0
144
1161
1.47
2.70
3.6
2.7
—
—
estimate
—
0
0
61
412
1.61
2.61
3.0
2.9
0.85
0.82
mmol/l
0.70
56
397
16
68
2.43
2.60
1.6
1.8
0.00
0.00
g/l
-0.00
16
59
15
62
2.50
2.58
5.7
3.3
3.81
4.02
mmol/l
0.95
15
62
33
188
1.85
2.58
4.5
2.3
4.63
4.46
kpa
0.22
33
182
6
11
5.54
2.55
1.2
1.3
—
—
—
0
0
37
220
1.78
2.53
6.3
3.0
2.59
1.84
mmol/l
0.65
30
188
134
1076
1.45
2.52
5.7
4.7
35.83
36.53
g/l
0.71
127
1020
7
16
4.45
2.49
1.6
2.8
—
—
—
0
0
25
132
1.98
2.44
7.1
2.6
24.55
24.39
mmol/l
0.09
25
132
89
664
1.49
2.43
2.8
2.6
343.84
341.68
umol/l
0.07
83
603
6
12
5.08
2.41
1.2
1.2
—
—
—
0
0
265
2455
1.76
2.33
4.5
4.1
1.30
1.32
mmol/l
0.18
254
2291
23
120
1.99
2.33
1.3
2.3
11.93
6.03
iu/ml
—
6
23
275
2577
1.95
2.31
5.3
4.9
1.42
1.46
mmol/l
1.06
266
2424
267
2480
1.78
2.31
17.7
13.1
85.08
84.85
ml/min/173m2
0.07
252
2298
40
250
1.69
2.31
2.0
2.5
136.47
33.22
u/l
0.60
34
204
257
2369
1.64
2.22
5.7
5.1
1.73
1.84
mu/l
0.98
248
2215
172
1468
1.41
2.20
10.2
10.0
4.05
4.00
e9/l
0.09
152
1291
36
225
1.68
2.09
6.4
2.9
6.00
5.82
kpa
0.43
36
217
211
1877
1.43
2.07
3.7
3.3
44.01
48.19
u/l
0.23
202
1798
67
487
1.49
2.05
1.5
1.3
3.11
9.84
u/ml
1.33
19
203
55
385
1.53
2.01
2.3
1.8
—
—
—
0
0
220
1976
1.44
2.01
4.5
4.3
14.67
14.64
pmol/l
0.06
212
1839
277
2620
1.89
1.98
6.3
5.5
2.53
2.81
mmol/l
5.22
270
2467
274
2584
1.81
1.96
5.4
4.9
4.41
4.74
mmol/l
6.05
268
2444
8
27
3.02
1.95
1.1
1.1
—
—
—
0
0
216
1940
1.42
1.92
9.1
8.1
72.39
78.29
u/l
2.29
207
1850
29
175
1.73
1.91
2.5
2.5
64.27
67.99
g/l
2.41
29
165
47
322
1.55
1.90
8.7
5.1
1.01
1.02
mmol/l
0.06
42
300
145
1228
1.35
1.82
3.9
2.9
121.39
120.51
ug/l
0.01
140
1162
260
2430
1.58
1.79
6.1
5.9
37.96
38.82
mmol/mol
1.06
254
2322
6
18
3.38
1.75
1.3
1.4
—
—
—
0
0
127
1060
1.35
1.73
2.2
2.0
90.61
97.26
pmol/l
0.91
67
563
19
104
1.88
1.71
8.4
4.6
2.04
1.52
%
0.83
14
98
6
19
3.20
1.67
1.2
3.5
0.50
0.79
index
—
6
19
5
14
3.61
1.62
1.0
1.1
—
—
—
0
0
39
266
1.54
1.62
9.2
6.5
—
—
—
0
0
11
50
2.25
1.59
1.6
1.4
—
—
—
0
0
5
15
3.37
1.53
1.0
1.5
118.60
101.47
%
—
5
15
10
45
2.26
1.48
1.6
1.2
—
—
—
0
0
288
2798
2.08
1.40
31.2
21.0
4.54
4.55
e12/l
0.16
282
2753
11
54
2.08
1.34
1.8
2.0
—
—
—
0
0
85
691
1.32
1.34
3.5
3.2
1385.39
944.46
ng/l
0.46
75
569
6
24
2.53
1.31
1.2
3.5
14.67
11.53
index
—
6
19
6
24
2.53
1.31
8.0
5.9
15.52
11.05
mg/l
—
6
24
13
70
1.90
1.26
1.0
1.1
—
—
—
0
0
6
25
2.43
1.25
2.5
2.7
0.73
0.74
mmol/l
—
6
25
101
850
1.29
1.22
3.0
3.3
2.35
2.35
mmol/l
0.13
93
788
13
71
1.87
1.21
1.0
1.1
—
—
—
0
0
15
87
1.76
1.17
2.5
1.3
—
—
—
0
0
53
410
1.36
1.16
1.5
1.4
—
—
—
0
0
82
677
1.29
1.15
1.6
1.6
19.04
20.89
nmol/l
0.57
72
593
7
32
2.22
1.09
1.0
1.2
—
—
—
0
0
7
32
2.22
1.09
1.1
1.2
—
—
—
0
0
259
2471
1.39
1.06
5.2
4.7
5.81
5.87
mmol/l
0.52
246
2309
119
1037
1.25
1.06
4.2
3.3
0.05
0.02
estimate
0.23
21
246
66
536
1.30
1.04
1.4
1.6
—
—
—
0
0
12
68
1.80
1.02
1.2
1.2
—
—
—
0
0
11
61
1.83
1.00
1.6
1.4
—
—
—
0
0
130
1151
1.23
0.98
1.7
1.9
1.32
1.41
mmol/l
0.72
112
991
22
149
1.51
0.98
2.4
2.0
—
—
—
0
0
12
69
1.77
0.98
4.3
2.7
24.59
25.48
mmol/l
0.67
12
69
28
200
1.44
0.98
1.1
1.3
123.78
156.78
u/ml
—
9
89
11
62
1.80
0.95
1.6
1.5
—
—
—
0
0
6
30
2.02
0.87
1.2
1.2
—
—
—
0
0
6
30
2.02
0.87
1.0
1.4
—
—
—
0
0
6
31
1.95
0.85
1.2
1.2
—
—
—
0
0
6
31
1.95
0.85
1.2
1.2
—
—
—
0
0
6
31
1.95
0.85
1.0
1.2
—
—
—
0
0
94
816
1.22
0.84
2.6
2.5
104.11
62.67
u/l
0.42
87
761
6
32
1.89
0.82
1.2
1.1
—
—
—
0
0
24
174
1.41
0.79
2.5
2.0
—
—
—
0
0
6
33
1.83
0.79
1.5
1.5
—
—
—
0
0
13
82
1.61
0.79
1.8
1.6
—
—
—
0
0
39
307
1.31
0.79
1.7
2.5
6.91
7.45
umol/l
0.16
33
271
0
27
0.00
0.78
0.0
1.2
—
—
—
0
0
6
34
1.78
0.76
1.2
1.2
—
—
—
0
0
57
475
1.25
0.75
2.8
2.7
2.46
2.44
mmol/l
0.53
52
423
7
39
1.81
0.73
1.9
1.8
13.29
13.12
%
—
7
39
5
27
1.87
0.68
2.0
1.7
—
—
—
0
0
40
325
1.27
0.65
2.5
2.1
—
—
—
0
0
36
289
1.28
0.65
2.3
2.0
—
—
—
0
0
8
49
1.65
0.62
1.0
1.9
—
—
—
0
0
78
687
1.18
0.60
4.4
4.3
19.22
22.23
%
0.93
31
301
0
23
0.00
0.58
0.0
1.3
—
—
—
0
0
12
81
1.50
0.58
1.8
2.0
107.08
250.48
ug/l
1.55
12
75
123
1128
1.15
0.57
2.4
2.5
79.85
75.71
nmol/l
0.61
114
1040
6
38
1.59
0.54
3.7
4.4
—
1041.00
—
0
7
6
39
1.55
0.53
1.2
1.3
—
—
—
0
0
22
170
1.32
0.53
1.4
1.6
—
—
—
0
0
6
99
0.60
0.53
2.0
2.0
289.17
218.96
pmol/l
—
6
93
12
83
1.46
0.52
2.5
2.6
1.45
1.36
mg/l
0.13
12
74
11
76
1.46
0.48
1.7
1.8
—
—
—
0
0
22
276
0.78
0.48
1.4
1.8
2.82
3.52
mmol/l
1.57
13
202
31
373
0.81
0.48
1.7
2.0
3.35
3.53
ratio
0.25
20
298
8
117
0.68
0.47
4.6
1.7
—
—
—
0
0
7
49
1.44
0.46
2.0
3.4
13.29
33.79
u/ml
—
7
49
7
49
1.44
0.46
1.3
1.3
24.73
16.52
u/l
—
7
43
7
50
1.41
0.45
1.4
1.5
—
—
—
0
0
6
94
0.63
0.43
4.2
3.6
180.00
1829.49
u/ml
—
6
80
17
132
1.31
0.41
1.1
1.3
—
—
—
0
0
0
17
0.00
0.41
0.0
1.1
—
—
—
0
0
0
17
0.00
0.41
0.0
1.9
—
—
—
0
0
5
35
1.44
0.39
1.2
1.4
0.18
0.18
nmol/l
—
5
26
0
19
0.00
0.39
0.0
1.3
—
—
—
0
0
10
72
1.40
0.37
1.8
1.6
—
—
—
0
0
53
472
1.15
0.37
1.5
1.8
422.17
28606789.25
pmol/l
0.50
48
409
11
81
1.37
0.36
1.1
1.5
—
—
—
0
0
13
99
1.33
0.36
1.2
1.4
157.88
266.45
miu/ml
—
8
51
16
126
1.29
0.36
3.3
1.6
—
—
—
0
0
6
42
1.44
0.35
1.2
1.1
—
—
—
0
0
6
42
1.44
0.35
1.2
1.1
—
—
—
0
0
6
88
0.68
0.33
1.0
1.3
—
—
—
0
0
6
89
0.67
0.33
2.2
1.9
—
—
—
0
0
68
621
1.12
0.33
1.3
1.3
3.01
1.83
u/ml
0.18
15
184
6
47
1.28
0.32
1.5
1.9
—
—
—
0
0
12
93
1.30
0.30
1.2
1.3
—
1.68
—
0
5
27
232
1.18
0.30
2.8
3.2
—
—
—
0
0
15
180
0.82
0.25
1.6
4.1
1.23
1.23
mmol/l
0.06
15
157
85
799
1.09
0.24
3.8
4.2
5.96
9.70
mg/mmol
0.63
54
508
5
38
1.32
0.23
1.6
1.6
—
—
—
0
0
11
88
1.26
0.23
1.2
1.4
—
11.18
—
0
19
11
88
1.26
0.23
1.2
1.3
—
1.79
—
0
10
5
41
1.22
0.22
5.6
2.7
15.54
16.42
%
—
5
41
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
6.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
178
1731
1.07
0.20
4.1
3.2
—
—
—
0
0
39
357
1.11
0.19
1.5
1.7
1213.06
1135.18
nmol/l
0.22
34
278
23
205
1.13
0.17
1.6
1.5
—
—
—
0
0
10
119
0.83
0.15
1.0
1.1
1.66
1.56
g/l
—
10
119
6
80
0.74
0.15
6.3
3.1
—
—
—
0
0
40
373
1.08
0.14
1.2
2.0
1.54
1.40
%
0.31
35
335
89
862
1.05
0.11
5.0
4.9
11.83
2.13
ug/l
0.52
80
777
56
539
1.05
0.08
3.0
3.0
0.56
0.72
ug/l
1.04
31
324
8
74
1.08
0.07
1.1
1.4
—
1.15
—
0
8
10
89
1.13
0.07
1.4
1.2
—
—
—
0
0
75
732
1.03
0.06
5.3
3.5
0.00
0.02
estimate
0.96
21
273
12
110
1.09
0.05
3.2
1.3
—
—
—
0
0
14
150
0.93
0.04
2.7
2.5
24.61
51.01
u/ml
0.81
14
145
76
770
0.98
0.02
3.4
2.8
0.27
0.11
estimate
0.39
22
236
13
131
0.99
0.00
1.2
1.1
—
—
—
0
0
10
95
1.05
0.00
1.4
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.5
—
212.88
—
0
8
0
9
0.00
-0.00
0.0
1.9
—
42.52
—
0
9
0
9
0.00
-0.00
0.0
1.0
—
0.21
—
0
9
5
54
0.92
-0.00
3.0
3.0
9.86
8.98
pmol/l
—
5
54
12
120
1.00
-0.00
1.0
1.1
0.92
0.90
g/l
0.13
12
120
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
57
0.88
-0.00
1.6
1.3
—
—
—
0
0
5
53
0.94
-0.00
5.6
2.3
130.80
132.67
g/l
—
5
39
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint I9_DISCER and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_DISCER | 1.628 [1.22, 2.17] | < 0.001 |
| Birth year | 0.997 [0.99, 1.01] | 0.506 |
During the follow-up period (1.1.1998 — 31.12.2019), 89 out of 624 females with I9_DISCER died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| I9_DISCER | 1.389 [1.11, 1.74] | 0.004 |
| Birth year | 0.99 [0.98, 1.0] | 0.035 |
During the follow-up period (1.1.1998 — 31.12.2019), 128 out of 787 males with I9_DISCER died.
Mortality risk
Mortality risk for people of age
years, who have I9_DISCER.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.099% | 0.298% |
| 5 | 0.878% | 1.694% |
| 10 | 2.544% | 4.33% |
| 15 | 4.874% | 8.115% |
| 20 | 8.809% | 14.239% |
Relationships between endpoints
↥Index endpoint: I9_DISCER – Dissection of cerebral arteries, nonruptured
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data