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Chronic constrictive pericarditis

Endpoint Browser PheWeb

I9_CHRONIC_CONSTRICTIVE_PERICARDITIS

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — I31.1
  • Cause of death: ICD-10 — I31.1

2 out of 7 registries used, show all original rules.

111

4. Check minimum number of events

None

111

5. Include endpoints

None

111

6. Filter based on genotype QC (FinnGen only)

95

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 95 26 69
Unadjusted period prevalence (%) 0.03 0.01 0.03
Median age at first event (years) 64.56 67.65 63.40

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
97
Matched controls
970
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
I31.1
ICD-10 Finland
Chronic constrictive pericarditis
+∞
139.8
97
*
I35.1
ICD-10 Finland
Aortic (valve) insufficiency
19.1
41.2
39
33
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
171.6
34.2
34
*
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
14.6
32.4
35
36
B01AA03
ATC
warfarin; systemic
10.5
30.8
63
146
I50.9
ICD-10 Finland
Heart failure, unspecified
10.0
30.0
59
130
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
7.9
23.5
50
115
C03CA01
ATC
furosemide; systemic
9.7
23.0
77
276
I50.0
ICD-10 Finland
Congestive heart failure
8.9
22.1
35
58
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
6.1
18.0
52
154
C03DA01
ATC
spironolactone; oral
6.5
17.1
38
88
I48
ICD-10 Finland
Atrial fibrillation and flutter
5.8
16.8
56
186
I31.9
ICD-10 Finland
Disease of pericardium, unspecified
58.3
16.7
19
*
ZXE20
NOMESCO Finland
More than three and less than five hours
6.2
16.6
39
95
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
5.7
16.4
58
202
C01AA05
ATC
digoxin; systemic
7.2
15.3
27
49
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
14.9
14.9
25
22
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
8.3
14.7
22
33
I31.3
ICD-10 Finland
Pericardial effusion (noninflammatory)
+∞
13.9
13
*
FEF10
NOMESCO Finland
Subtotal pericardiectomy
+∞
13.9
13
*
TFP20
NOMESCO Finland
Cardiodefibrillation
6.4
13.9
28
58
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
4.8
13.6
53
193
I34.1
ICD-10 Finland
Mitral (valve) prolapse
15.4
13.4
22
18
WX872
NOMESCO Finland
Intensive care
13.9
12.8
22
20
I34.09
ICD-10 Finland
Mitral (valve) insufficiency
12.2
12.6
23
24
Z95.2
ICD-10 Finland
Presence of prosthetic heart valve
31.5
12.5
16
6
201
Kela drug reimbursment
Chronic cardiac insufficiency
5.9
11.4
24
51
C07AB07
ATC
bisoprolol; oral
5.8
11.4
80
436
AN1
HP
Coronary angiography
4.9
11.1
31
85
I35.0
ICD-10 Finland
Aortic (valve) stenosis
5.8
10.9
23
49
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
21.8
10.6
15
8
WX408
NOMESCO Finland
General anesthesy, balanced
4.1
10.5
44
163
GD1AA
NOMESCO Finland
Thorax X-ray examination
4.5
9.7
74
407
FMD00
NOMESCO Finland
Replacement of aortic valve using mechanical prosthesis
110.3
9.6
10
*
I50.1
ICD-10 Finland
Left ventricular failure
8.7
9.3
20
28
ZXD05
NOMESCO Finland
Urgent procedure
3.7
9.2
47
197
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.4
9.1
28
82
R06.0
ICD-10 Finland
Dyspnoea
3.6
8.8
50
222
207
Kela drug reimbursment
Chronic arrhythmias
3.9
8.7
34
118
XF400
NOMESCO Finland
ECG with 12 standard connections
3.8
8.1
32
111
WX892
NOMESCO Finland
Monitored bed care
5.3
8.0
18
40
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
5.0
7.9
19
45
K78
ICPC
Atrial fibrillation/flutter
4.8
7.8
20
50
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
8.0
7.7
17
25
C07AB02
ATC
metoprolol; systemic
3.4
7.7
38
153
AJ1
HP
Reconstruction of the aortic base, eg composite graft, incl. valve saving operation
+∞
7.4
7
*
I34.00
ICD-10 Finland
Mitral (valve) incompetence NOS or of specified cause, except rheumatic
13.5
7.3
12
10
XF404
NOMESCO Finland
Ambulatory ECG
4.7
7.3
19
48
Z95.0
ICD-10 Finland
Presence of electronic cardiac devices
6.7
7.2
18
32
R18
ICD-10 Finland
Ascites
18.3
6.9
10
6
K83
ICPC
Heart valve disease NOS
43.2
6.9
8
*
C01BD01
ATC
amiodarone; systemic
11.2
6.7
12
12
AP3
HP
Catheterization of the right and left side of the heart
74.5
6.5
7
*
I50
ICD-10 Finland
Heart failure
8.0
6.5
14
20
TFB00
NOMESCO Finland
Cathetrisation of pulmonal artery
19.6
6.4
9
5
I71.9
ICD-10 Finland
Aortic aneurysm of unspecified site, without mention of rupture
19.6
6.4
9
5
I97.0
ICD-10 Finland
Postcardiotomy syndrome
+∞
6.3
6
*
B03XA02
ATC
darbepoetin alfa; parenteral
16.3
6.0
9
6

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
12
23
5.80
4.63
1.2
1.4
—
—
—
0
0
69
472
2.60
4.41
51.5
15.3
1.87
1.27
inr
8.24
62
389
33
169
2.44
3.91
3.7
3.9
0.82
0.82
mmol/l
0.09
33
160
7
11
6.76
3.24
3.3
3.9
—
—
—
0
0
5
5
10.44
3.01
1.0
1.0
—
—
—
0
0
44
281
2.04
2.91
4.9
4.7
7.40
7.40
ph
0.24
37
199
38
231
2.06
2.86
3.0
2.2
3.54
3.03
mg/l
0.55
32
205
28
155
2.13
2.67
3.8
2.2
32.46
29.03
s
2.20
28
150
66
789
0.49
2.56
7.0
7.4
40.17
40.59
mmol/mol
0.16
60
735
6
12
5.25
2.44
1.7
2.0
—
—
—
0
0
71
824
0.48
2.37
6.0
6.3
2.16
2.56
mmol/l
4.40
64
750
6
13
4.84
2.31
2.2
3.2
34.33
32.92
pg
—
6
13
7
18
4.10
2.30
3.3
2.9
—
—
—
0
0
29
172
1.98
2.27
6.0
3.9
974.34
320.63
ng/l
0.47
29
148
45
311
1.83
2.21
5.9
5.0
—
—
—
0
0
18
93
2.15
2.01
1.9
1.7
—
—
—
0
0
5
11
4.73
1.96
1.6
1.5
—
—
—
0
0
5
11
4.73
1.96
1.0
1.0
—
—
—
0
0
18
305
0.50
1.93
1.9
3.2
0.82
0.79
ug/l
0.07
12
205
70
805
0.53
1.92
5.6
5.5
3.87
4.44
mmol/l
5.27
62
731
19
103
2.05
1.88
1.9
1.6
—
—
—
0
0
18
96
2.07
1.86
3.1
4.0
63.39
69.97
e9/l
0.57
13
70
70
803
0.54
1.84
5.6
5.5
1.26
1.39
mmol/l
1.99
62
727
7
23
3.20
1.83
1.1
1.2
—
—
—
0
0
54
412
1.70
1.77
6.1
4.5
47.43
44.96
ng/l
0.05
44
319
12
55
2.35
1.76
7.4
3.5
24.16
24.11
mmol/l
0.02
12
55
57
443
1.70
1.73
12.7
8.7
1.18
1.20
mmol/l
1.97
50
386
68
782
0.56
1.69
4.8
4.7
1.27
1.30
mmol/l
0.15
62
706
16
85
2.06
1.67
7.8
10.3
—
—
—
0
0
5
14
3.70
1.63
1.0
1.1
—
—
—
0
0
27
176
1.74
1.54
2.4
1.6
1308.47
1235.91
nmol/l
0.12
19
132
70
793
0.58
1.51
5.9
5.7
6.04
6.10
mmol/l
0.16
63
718
24
155
1.73
1.40
3.3
1.9
—
—
—
0
0
11
54
2.17
1.39
1.2
1.3
—
—
—
0
0
18
107
1.84
1.38
2.4
1.8
—
—
—
0
0
40
299
1.57
1.33
6.2
7.0
—
—
—
0
0
12
63
2.03
1.29
3.7
4.0
—
—
—
0
0
14
79
1.90
1.25
1.3
3.0
—
—
—
0
0
38
289
1.52
1.14
3.5
2.9
—
—
—
0
0
18
116
1.68
1.06
4.5
8.9
7.44
7.42
ph
0.68
12
68
5
22
2.34
1.04
1.0
1.3
—
—
—
0
0
0
30
0.00
0.99
0.0
1.2
—
—
—
0
0
27
197
1.51
0.96
1.7
1.8
1.22
1.72
mg/l
0.72
22
163
82
874
0.60
0.91
48.1
29.3
92.71
91.52
fl
1.16
77
864
82
874
0.60
0.91
48.2
29.4
212.45
237.85
e9/l
3.47
76
855
82
874
0.60
0.91
48.5
29.5
6.71
6.92
e9/l
0.40
77
854
82
874
0.60
0.91
48.1
29.2
30.40
30.49
pg
0.16
77
864
82
874
0.60
0.91
48.6
29.9
39.03
40.61
%
1.93
76
863
82
874
0.60
0.91
48.1
29.3
4.27
4.52
e12/l
2.65
76
853
82
874
0.60
0.91
48.8
29.5
127.62
136.29
g/l
4.05
77
865
14
89
1.67
0.87
3.6
5.3
0.13
0.92
%
—
8
37
17
115
1.58
0.84
2.1
1.7
—
—
—
0
0
13
82
1.68
0.83
3.3
5.1
0.14
0.35
%
—
7
33
13
84
1.63
0.76
3.6
5.3
0.00
0.19
%
—
7
32
5
25
2.05
0.74
1.2
1.2
—
—
—
0
0
5
27
1.90
0.69
1.2
1.5
—
—
—
0
0
26
324
0.73
0.64
2.6
3.6
—
—
—
0
0
23
177
1.39
0.62
1.2
1.3
2.01
1.09
u/ml
—
7
55
0
22
0.00
0.60
0.0
1.4
—
—
—
0
0
0
22
0.00
0.60
0.0
1.4
—
—
—
0
0
0
22
0.00
0.60
0.0
1.4
—
—
—
0
0
0
22
0.00
0.60
0.0
1.4
—
—
—
0
0
12
82
1.53
0.57
6.7
3.1
7.42
7.43
ph
0.26
12
67
32
381
0.76
0.57
3.2
3.9
6.10
6.19
ph
0.18
15
212
9
59
1.58
0.57
7.4
3.3
—
—
—
0
0
15
200
0.70
0.55
4.1
4.8
1.02
1.02
kg/l
—
9
131
46
400
1.29
0.55
1.9
2.2
85.28
94.21
pmol/l
0.76
21
212
9
63
1.47
0.54
1.1
1.6
—
—
—
0
0
10
67
1.55
0.52
1.8
1.4
—
—
—
0
0
18
230
0.73
0.51
2.1
3.1
—
0.29
—
0
7
20
158
1.33
0.46
2.1
3.1
6.60
1.68
e6/l
—
10
80
42
473
0.80
0.45
3.8
4.3
0.00
0.00
estimate
—
8
105
69
735
0.79
0.43
5.3
4.8
2.50
2.05
mu/l
0.78
62
652
37
322
1.24
0.42
5.8
4.2
—
—
—
0
0
0
15
0.00
0.41
0.0
2.9
—
4.10
—
0
15
0
15
0.00
0.41
0.0
2.9
—
1.19
—
0
15
0
15
0.00
0.41
0.0
2.9
—
106.00
—
0
15
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
30
348
0.80
0.41
4.2
4.5
0.00
0.03
estimate
—
8
94
0
17
0.00
0.41
0.0
1.4
—
—
—
0
0
46
411
1.23
0.40
15.8
14.0
0.00
0.01
e9/l
0.28
35
328
0
18
0.00
0.40
0.0
2.1
—
10.22
—
0
18
42
468
0.82
0.39
3.8
4.3
0.00
14.12
estimate
—
9
115
5
36
1.41
0.39
1.2
1.2
—
—
—
0
0
6
43
1.42
0.36
3.8
3.0
—
—
—
0
0
10
74
1.39
0.34
5.8
3.6
—
—
—
0
0
42
462
0.84
0.32
3.7
4.2
0.00
0.00
estimate
—
9
112
43
389
1.19
0.32
5.0
3.2
—
—
estimate
—
0
0
22
257
0.81
0.31
4.3
3.8
0.00
0.00
estimate
—
8
92
7
55
1.29
0.30
4.7
3.9
36.94
36.97
°c
—
7
55
33
293
1.19
0.29
3.5
3.0
0.66
0.44
e6/l
0.28
27
212
5
37
1.37
0.24
1.4
1.6
—
—
—
0
0
11
88
1.28
0.24
3.7
5.8
0.00
0.09
%
—
5
32
7
91
0.75
0.23
1.6
1.3
—
—
—
0
0
30
332
0.86
0.23
2.3
2.2
—
—
—
0
0
20
173
1.20
0.23
1.6
1.6
4.16
3.02
g/l
0.76
14
109
13
107
1.25
0.23
1.5
1.5
—
—
—
0
0
15
126
1.23
0.22
1.3
1.3
1.73
8.10
u/ml
—
7
45
51
478
1.14
0.22
5.6
7.4
0.20
0.19
e9/l
0.12
42
418
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
2.2
—
—
—
0
0
0
11
0.00
0.21
0.0
2.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
0.08
—
0
5
0
10
0.00
0.21
0.0
8.3
—
16.84
—
0
10
0
12
0.00
0.21
0.0
4.6
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
50
472
1.12
0.18
5.5
7.1
1.47
1.73
e9/l
1.38
42
417
71
685
1.14
0.17
10.6
9.3
99.59
83.02
u/l
0.90
63
646
8
70
1.16
0.17
7.8
4.3
—
—
—
0
0
22
198
1.14
0.16
4.2
5.9
—
—
—
0
0
30
324
0.89
0.15
2.1
2.0
1.44
1.37
mmol/l
0.15
25
263
49
465
1.11
0.15
5.4
6.9
0.71
0.62
e9/l
1.48
41
399
54
516
1.10
0.14
7.8
11.8
4.38
4.32
e9/l
0.06
46
450
49
467
1.10
0.13
5.4
6.9
0.04
0.04
e9/l
0.04
41
400
81
827
0.88
0.12
31.6
17.7
—
—
—
0
0
80
817
0.88
0.12
32.3
19.7
28.07
26.02
mg/l
0.24
70
701
29
271
1.10
0.11
8.2
7.1
—
—
—
0
0
17
154
1.13
0.11
6.5
8.1
104.12
103.99
mmol/l
0.05
17
154
24
258
0.91
0.11
2.6
3.4
—
—
—
0
0
82
835
0.88
0.10
43.6
23.7
4.05
4.02
mmol/l
0.60
75
819
5
46
1.09
0.10
1.0
1.1
—
—
—
0
0
13
117
1.13
0.08
1.5
1.3
—
—
—
0
0
6
58
1.04
0.08
3.3
2.7
0.58
0.62
%
—
6
58
14
127
1.12
0.08
1.3
1.3
—
—
—
0
0
82
833
0.90
0.08
43.3
23.5
138.81
139.66
mmol/l
2.16
75
818
20
214
0.92
0.07
1.4
1.4
—
—
—
0
0
10
89
1.14
0.07
5.0
9.1
0.95
1.37
mmol/l
—
10
89
8
92
0.86
0.07
1.3
1.4
—
—
—
0
0
30
312
0.94
0.05
4.7
4.2
18.22
9.71
mg/mmol
0.27
22
206
12
111
1.09
0.04
1.4
1.4
—
—
—
0
0
60
591
1.04
0.02
4.0
3.8
15.06
15.01
pmol/l
0.05
55
530
34
348
0.96
0.02
3.7
3.3
10.43
250.19
e6/l
0.70
28
266
37
377
0.97
0.01
4.0
3.8
18.10
102.06
e6/l
1.31
29
274
27
276
0.97
0.00
4.3
4.4
0.00
0.02
estimate
—
8
102
30
299
1.00
0.00
3.6
3.5
95.54
62.01
mg/l
0.23
21
204
30
303
0.99
0.00
3.7
3.5
7.80
8.07
mmol/l
0.13
24
256
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
2.03
—
0
5
0
9
0.00
-0.00
0.0
1.4
—
5.26
—
0
9
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
5
53
0.94
-0.00
1.2
1.8
44.80
42.02
nmol/l
—
5
53
6
65
0.92
-0.00
1.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
74.70
—
0
5
0
9
0.00
-0.00
0.0
2.7
—
35.01
—
0
9
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
24.2
—
1735.50
—
0
6
6
59
1.02
-0.00
3.3
2.7
1.05
1.11
%
—
6
59
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.3
—
3.73
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.3
—
2.32
—
0
6
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
8
88
0.90
-0.00
1.6
2.1
427.88
133.41
ug/g
—
8
71
0
5
0.00
-0.00
0.0
1.4
—
215.20
—
0
5
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
11.0
—
0.72
—
0
5
0
5
0.00
-0.00
0.0
2.2
—
26.28
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
137.80
—
0
5
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
17.7
—
860.17
—
0
6
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0

Mortality – FinRegistry

↥

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

↥

Index endpoint: I9_CHRONIC_CONSTRICTIVE_PERICARDITIS – Chronic constrictive pericarditis

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).