Cardiomyopathy, Hypertrophic obstructive

I9_CARDMYOHYP

hypertrophic cardiomyopathy: A condition in which the myocardium is hypertrophied without an obvious cause. The hypertrophy is generally asymmetric and may be associated with obstruction of the ventricular outflow tract.

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Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 I42.1
  • Hospital discharge: ICD-9 4251A
  • Hospital discharge: ICD-8 42500
  • Cause of death: ICD-10 I42.1
  • Cause of death: ICD-9 4251A
  • Cause of death: ICD-8 42500

2 out of 7 registries used, show all original rules.

782

4. Check minimum number of events

None

782

5. Include endpoints

None

782

6. Filter based on genotype QC (FinnGen only)

691

Control definitions (FinnGen only)

Control exclude
I9_OTHHEART

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF5
Parent code in ICD-10
I42
Name in latin
Cardiomyopathia hypertrophica obstructiva

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 5095 2157 2870
Only index persons 3542 1521 2021
Unadjusted period prevalence (%)
Whole population 0.07 0.06 0.08
Only index persons 0.07 0.06 0.08
Median age at first event (years)
Whole population 59.89 63.64 56.99
Only index persons 58.98 62.46 56.35

-FinnGen-

Key figures

All Female Male
Number of individuals 691 294 397
Unadjusted period prevalence (%) 0.15 0.10 0.18
Median age at first event (years) 59.23 59.91 58.72

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
726
Matched controls
7260
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
I48
ICD-10 Finland
Atrial fibrillation and flutter
272.4
307.7
352
25
I50.9
ICD-10 Finland
Heart failure, unspecified
112.5
307.7
283
41
207
Kela drug reimbursment
Chronic arrhythmias
1861.6
307.7
317
*
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
21.1
307.7
421
446
201
Kela drug reimbursment
Chronic cardiac insufficiency
107.6
307.7
244
34
XF404
NOMESCO Finland
Ambulatory ECG
44.3
307.7
246
83
I42.2
ICD-10 Finland
Other hypertrophic cardiomyopathy
+∞
307.7
347
*
I42.1
ICD-10 Finland
Obstructive hypertrophic cardiomyopathy
+∞
307.7
668
*
I42.0
ICD-10 Finland
Dilated cardiomyopathy
+∞
287.1
256
*
B01AA03
ATC
warfarin; systemic
15.4
280.1
309
333
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
630.4
270.9
252
6
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
12.7
267.0
372
553
C03DA01
ATC
spironolactone; oral
14.8
254.5
278
292
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
1106.8
248.4
229
*
C01AA05
ATC
digoxin; systemic
54.7
238.6
138
31
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
+∞
234.5
212
*
Z95.0
ICD-10 Finland
Presence of electronic cardiac devices
944.9
220.1
205
*
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
9.8
215.1
383
742
C03CA01
ATC
furosemide; systemic
9.3
206.8
435
1005
C07AB07
ATC
bisoprolol; oral
11.7
195.5
589
1951
I42.9
ICD-10 Finland
Cardiomyopathy, unspecified
+∞
187.9
172
*
TFP20
NOMESCO Finland
Cardiodefibrillation
569.0
183.9
175
*
I50.0
ICD-10 Finland
Congestive heart failure
547.6
178.2
170
*
B01AF02
ATC
apixaban; oral
15.2
175.4
170
143
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
17.4
171.5
152
109
Z45.0
ICD-10 Finland
Adjustment and management of cardiac devices
1029.1
171.2
161
*
I50.1
ICD-10 Finland
Left ventricular failure
1668.8
144.9
136
*
C01BD01
ATC
amiodarone; systemic
542.0
139.2
134
*
XF402
NOMESCO Finland
ECG with work load test
8.6
131.3
200
308
K78
ICPC
Atrial fibrillation/flutter
30.8
129.9
87
32
I47.2
ICD-10 Finland
Ventricular tachycardia
728.6
127.5
122
*
I48.0
ICD-10 Finland
Paroxysmal atrial fibrillation
151.5
110.7
115
9
I47.1
ICD-10 Finland
Supraventricular tachycardia
66.5
110.5
61
10
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
6.1
107.4
241
545
C07AA07
ATC
sotalol; systemic
22.9
107.2
80
39
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
9.7
106.4
137
170
XF640, ,
NOMESCO Finland
30.9
105.1
70
25
AN1
HP
Coronary angiography
7.2
102.7
181
322
I35.0
ICD-10 Finland
Aortic (valve) stenosis
52.4
100.4
58
12
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
151.4
100.0
104
8
FPE20
NOMESCO Finland
Implantation of transvenous cardiac pacemaker with atrial and ventricular electrodes
+∞
99.3
93
*
I11.9
ICD-10 Finland
Hypertensive heart disease without (congestive) heart failure
13.9
97.8
95
78
I35.1
ICD-10 Finland
Aortic (valve) insufficiency
53.0
93.7
54
11
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
509.3
92.5
90
*
I44.2
ICD-10 Finland
Atrioventricular block, complete
+∞
91.6
86
*
I50
ICD-10 Finland
Heart failure
43.0
86.1
52
13
FM1DG
NOMESCO Finland
Very extensive MRI examination of heart with high intesity magnet
227.5
80.0
81
*
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
13.1
79.4
79
67
I48.2
ICD-10 Finland
Chronic atrial fibrillation
820.6
76.8
74
*
TFB00
NOMESCO Finland
Cathetrisation of pulmonal artery
27.9
75.8
52
20
I34.09
ICD-10 Finland
Mitral (valve) insufficiency
401.3
74.1
73
*
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
9.8
71.8
88
101
GD1AA
NOMESCO Finland
Thorax X-ray examination
4.0
70.8
473
2315
I25.1
ICD-10 Finland
Atherosclerotic heart disease
4.2
68.9
258
851
4251A
ICD-9 Finland
Cardiomyopathy, Hypertrophic obstructive cardiomyopathy
+∞
68.9
65
*
FPG32
NOMESCO Finland
Implantation of cardioverter-defibrillator with atrial and ventricular electrodes
+∞
66.7
63
*
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
6.4
63.8
117
212
250, ,
Kela drug reimbursment
142.5
62.0
65
5
I49.5
ICD-10 Finland
Sick sinus syndrome
142.5
62.0
65
5
FJA10
NOMESCO Finland
Transvenous biopsy of right ventricle
+∞
61.3
58
*
FPG30
NOMESCO Finland
Implantation of cardioverter-defibrillator with ventricular electrode
+∞
61.3
58
*
C09AA05
ATC
ramipril; oral
3.7
61.2
287
1091
WX892
NOMESCO Finland
Monitored bed care
6.1
58.7
113
214
XFE00
NOMESCO Finland
Epicardial ultrasonography
16.9
57.7
49
31
XF400
NOMESCO Finland
ECG with 12 standard connections
4.2
57.5
193
580
GD1LA
NOMESCO Finland
GD
209.7
56.9
58
*
I49.3
ICD-10 Finland
Ventricular premature depolarization
12.3
54.8
56
49
289
Kela drug reimbursment
Combination product containing sacubitril and valsartan
+∞
53.8
51
*
I48.1
ICD-10 Finland
Persistent atrial fibrillation
151.4
53.6
56
*
C07AB02
ATC
metoprolol; systemic
3.8
53.3
215
731
127
Kela drug reimbursment
Transplant complication
15.6
53.2
47
32
K84
ICPC
Heart disease other
12.1
52.3
54
48
TFP34
NOMESCO Finland
Electrophysiological investigation
545.2
52.1
51
*
C08DA01
ATC
verapamil; systemic
9.6
50.9
62
70
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
6.4
50.5
89
154
WX872
NOMESCO Finland
Intensive care
7.7
50.0
74
106
L04AA06
ATC
mycophenolic acid; systemic
13.1
50.0
49
40
81
HP
Angiography of the heart and coronary arteries
6.2
50.0
92
166
C09DX04
ATC
valsartan and sacubitril; oral
+∞
49.5
47
*
Z2221
NOMESCO Finland
Medical doctor
3.3
49.4
280
1172
I34.00
ICD-10 Finland
Mitral (valve) incompetence NOS or of specified cause, except rheumatic
510.6
49.0
48
*
A12BA01
ATC
potassium chloride; oral
7.8
48.2
70
98
381
Kela drug reimbursment
Combination product containing sacubitril and valsartan
+∞
47.4
45
*
FPE30
NOMESCO Finland
Replacement of transvenous cardiac pacemaker pulse generator
+∞
46.3
44
*
M04AA01
ATC
allopurinol; systemic
3.9
45.6
158
480
I49.0
ICD-10 Finland
Ventricular fibrillation and flutter
+∞
45.3
43
*
Z94.1
ICD-10 Finland
Heart transplant status
116.9
41.2
44
*
R06.0
ICD-10 Finland
Dyspnoea
3.0
40.7
251
1083
TK800
NOMESCO Finland
Hemodialysis
11.1
40.6
44
42
TFP30
NOMESCO Finland
Cathetric examination for cardiac arrythmia
419.8
40.5
40
*
L04AD02
ATC
tacrolimus; systemic
15.3
39.3
35
24
PH1AC
NOMESCO Finland
Flebography of over extremity with X-ray
111.3
39.2
42
*
I63.4
ICD-10 Finland
Cerebral infarction due to embolism of cerebral arteries
12.0
39.0
40
35
C01BA03
ATC
disopyramide; systemic
397.4
38.4
38
*
I42.8
ICD-10 Finland
Other cardiomyopathies
+∞
36.8
35
*
AP1
HP
Catheterization of the left side of the heart
14.2
36.7
34
25
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
4.5
35.9
94
230
R55
ICD-10 Finland
Syncope and collapse
3.7
35.7
129
399
R00.1
ICD-10 Finland
Bradycardia, unspecified
10.8
35.4
39
38
FPG96
NOMESCO Finland
Other implantation of permanent cardioverter-defibrillator
+∞
34.7
33
*
FN2EG
NOMESCO Finland
Catheter-based alcohol septal ablation
+∞
34.7
33
*
4273A
ICD-9 Finland
Cardiac dysrhythmias, Atrial fibrillation and flutter
+∞
34.7
33
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
5.0
34.5
79
173
FP4B5
NOMESCO Finland
ECG, prolonged recording (24 h)
43.4
33.4
41
10
XF655
NOMESCO Finland
Measurement of heart muscle perfusion with exercise
8.3
32.7
44
56
Z3231
NOMESCO Finland
Registered nurse
2.7
32.3
256
1236
TFP00
NOMESCO Finland
Temporary use of transvenous or epicardial pacemaker
91.9
32.0
35
*
FQA10
NOMESCO Finland
Orthotopic transplantation of heart with bicaval anastomosis
+∞
31.5
30
*
FPE00
NOMESCO Finland
Implantation of transvenous cardiac pacemaker with ventricular electrode
+∞
31.5
30
*
I44.1
ICD-10 Finland
Atrioventricular block, second degree
167.1
30.9
32
*
G04BE03
ATC
sildenafil; oral
8.9
30.8
39
46
FPH10
NOMESCO Finland
Open removal of transvenous cardiac pacemaker or cardioverter-defibrillator
+∞
30.4
29
*
71
HP
Electrophysiological Special Examination
+∞
30.4
29
*
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
2.7
30.0
224
1044
AS8
HP
Physiological arrhythmia pacemaker insertionDDD (R) S
+∞
29.4
28
*
I46.0
ICD-10 Finland
Cardiac arrest with successful resuscitation
+∞
29.4
28
*
42500
ICD-8 Finland
Cardiomyopathy, Stenosis subaortae hypertrophicans
+∞
29.4
28
*
A10BK01
ATC
dapagliflozin; oral
4.1
29.2
87
234
ZXE00
NOMESCO Finland
One hour or less
2.4
28.7
325
1831
I42
ICD-10 Finland
Cardiomyopathy
+∞
28.3
27
*
I35.2
ICD-10 Finland
Aortic (valve) stenosis with insufficiency
292.2
27.9
28
*
R07.4
ICD-10 Finland
Chest pain, unspecified
2.5
27.9
246
1236
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
6.1
27.4
49
85
AQ1
HP
Conventional electrophysiological examination
+∞
27.3
26
*
AS4
HP
Physiological pacemaker insertion DDD (R)
+∞
27.3
26
*
TFP35
NOMESCO Finland
Electroanatomical mapping
281.0
26.9
27
*
I11.0
ICD-10 Finland
Hypertensive heart disease with (congestive) heart failure
100.6
26.8
29
*
R4110
NOMESCO Finland
Physiotherapy
2.4
26.6
254
1318
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.7
26.5
169
722
ZXD10
NOMESCO Finland
Scheduled procedure
2.3
26.5
319
1831
N17.9
ICD-10 Finland
Acute renal failure, unspecified
5.6
26.4
52
99
K77
ICPC
Heart failure
38.3
26.4
33
9
FPG40
NOMESCO Finland
Replacement of pulse generator in transvenous cardioverter-defibrillator
+∞
26.2
25
*
I34.1
ICD-10 Finland
Mitral (valve) prolapse
62.5
26.2
30
5
C07AG02
ATC
carvedilol; oral
4.3
25.5
69
172
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.8
25.4
150
615
TPH07
NOMESCO Finland
Cathetrisation of artery
3.2
25.2
114
403
FPJ22
NOMESCO Finland
Revision of cardioverter-defibrillator with atrial and ventricular electrodes
+∞
25.1
24
*
M10.9
ICD-10 Finland
Gout, unspecified
3.8
24.8
82
237
C01BC04
ATC
flecainide; systemic
134.6
24.8
26
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.4
24.3
233
1204
I44.7
ICD-10 Finland
Left bundle-branch block, unspecified
58.1
24.2
28
5
TFP46
NOMESCO Finland
Ablation treatment of atrial fibrillation
+∞
24.1
23
*
206
Kela drug reimbursment
Chronic coronary artery disease and dyslipidaemia associated with chronic coronary artery disease
2.6
23.9
161
705
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.2
23.8
107
376
WX740
NOMESCO Finland
Nitrogen oxide therapy
247.8
23.8
24
*
C01DA14
ATC
isosorbide mononitrate; oral
2.8
23.5
138
563
ZXD05
NOMESCO Finland
Urgent procedure
2.3
23.3
234
1230
B01AE07
ATC
dabigatran etexilate; oral
7.4
23.1
34
48
TFC25
NOMESCO Finland
Transseptal catheterisation of left atrium or ventricle
+∞
23.0
22
*
FM1CG
NOMESCO Finland
Extensive examination of hear with high intensity magnet
86.3
22.8
25
*
Z95.2
ICD-10 Finland
Presence of prosthetic heart valve
237.2
22.7
23
*
FLE10
NOMESCO Finland
Myotomy or myectomy of left ventricle for outlet obstruction
+∞
22.0
21
*
TFJ02
NOMESCO Finland
Muscle biopsy of heart
+∞
22.0
21
*
I45.9
ICD-10 Finland
Conduction disorder, unspecified
82.7
21.8
24
*
ZXE40
NOMESCO Finland
More than seven and less than nine hours
7.4
21.8
32
45
I36.1
ICD-10 Finland
Nonrheumatic tricuspid (valve) insufficiency
226.5
21.7
22
*
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.2
21.5
94
324
ZXE10
NOMESCO Finland
More than one and less than three hours
2.1
21.0
296
1770
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
3.2
21.0
88
296
AP4
HP
Myocardial biopsy
+∞
20.9
20
*
TPH04
NOMESCO Finland
Cathetrisation of vein
2.4
20.7
188
939
D64.9
ICD-10 Finland
Anaemia, unspecified
2.9
20.5
106
402
I20.00
ICD-10 Finland
Unstable angina
5.8
20.3
38
69
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
7.3
19.6
29
41
ZXE20
NOMESCO Finland
More than three and less than five hours
2.6
19.6
125
529
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
4.2
19.0
53
135
TFC10
NOMESCO Finland
Catheterisation of left atrium or ventricle
8.3
18.9
25
31
FPE40
NOMESCO Finland
Replacement of transvenous cardiac pacemaker electrode
+∞
18.8
18
*
42509
ICD-8 Finland
Cardiomyopathy, Unspecified
+∞
18.8
18
*
ZXE30
NOMESCO Finland
More than five and less than seven hours
4.1
18.4
52
134
TK810
NOMESCO Finland
Hemofiltration
25.8
18.3
25
10
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
2.3
18.2
160
783
WX408
NOMESCO Finland
General anesthesy, balanced
2.2
18.1
210
1153
K80
ICPC
Cardiac arrhythmia NOS
3.6
17.9
61
179
PH1AE
NOMESCO Finland
Ultrasound examination of upper extremity veins
7.8
17.9
25
33
Z2446
NOMESCO Finland
Social worker
3.4
17.8
68
215
TFP32
NOMESCO Finland
Cathetric treatmen of cardiac arrythmia
+∞
17.8
17
*
TFP47
NOMESCO Finland
Ablation or modification of the AV-node
+∞
17.8
17
*
C03EB01
ATC
furosemide and potassium-sparing agents; systemic
4.7
17.7
42
94
AP2
HP
Catheterization of the right side of the heart
97.5
17.6
19
*
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
6.7
17.6
28
43
Z31.5
ICD-10 Finland
Genetic counselling
4.0
17.5
51
134
Z3226
NOMESCO Finland
Physiotherapist
2.3
17.2
157
780
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.1
17.0
233
1356
C08CA02
ATC
felodipine; oral
2.9
16.8
88
335
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
4.9
16.8
37
78
3A064, ,
NOMESCO Finland
+∞
16.7
16
*
FPE96
NOMESCO Finland
Other implantation or replacement of transvenous cardiac pacemaker
+∞
16.7
16
*
7AX01, ,
NOMESCO Finland
173.8
16.6
17
*
C08DB01
ATC
diltiazem; oral
3.8
16.2
50
137
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
3.5
16.1
58
177
AP3
HP
Catheterization of the right and left side of the heart
+∞
15.7
15
*
AS7
HP
Arrhythmia pacemaker insertion VVI (R) S
+∞
15.7
15
*
FPJ24
NOMESCO Finland
Revision of biventricular cardioverter-defibrillator with atrial and ventricular electrodes
+∞
15.7
15
*
ATX
HP
Other pacemaker replacement or related action, such as cord removal or replacement
+∞
15.7
15
*
1CX08, ,
NOMESCO Finland
87.0
15.6
17
*
I25.5
ICD-10 Finland
Ischaemic cardiomyopathy
22.6
15.6
22
10
TKC20
NOMESCO Finland
Catheterisation of bladder
3.1
15.4
67
230
C10AA01
ATC
simvastatin; oral
1.9
15.2
340
2317
C09AA04
ATC
perindopril; oral
3.8
15.2
48
134
I20.99
ICD-10 Finland
Angina pectoris, unspecified
3.3
15.1
58
184
R02
ICPC
Shortness of breath/dyspnoea
2.5
15.1
107
474
I47.9
ICD-10 Finland
Paroxysmal tachycardia, unspecified
32.5
14.9
19
6
FM1LE
NOMESCO Finland
Combined ultrasound and EKG examination of heart with tolerance test
21.6
14.7
21
10
C03AA03
ATC
hydrochlorothiazide; oral
2.8
14.7
77
293
72
HP
Catheter ablation of arrhythmia
+∞
14.6
14
*
74
HP
Initial installation of the atrial pacemaker
+∞
14.6
14
*
FM1DM
NOMESCO Finland
Heart very extensive MRI examination with 3 Tesla magnet
+∞
14.6
14
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.4
14.6
113
521
C01BA01
ATC
quinidine; oral
153.0
14.5
15
*
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.0
14.5
67
238
XF600
NOMESCO Finland
Bloodpressure measurement
3.3
14.0
55
177
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.1
14.0
149
783
ZX120
NOMESCO Finland
Intravenous
2.6
14.0
84
343
M10
ICD-10 Finland
Gout
3.6
13.8
46
133
H02AB06
ATC
prednisolone; systemic
1.8
13.8
338
2349
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
3.7
13.7
45
129
FPH96
NOMESCO Finland
Other removal of cardiac pacemaker or cardioverter-defibrillator
76.6
13.6
15
*
A46
ICD-10 Finland
Erysipelas
2.3
13.6
118
570
I31.9
ICD-10 Finland
Disease of pericardium, unspecified
+∞
13.6
13
*
R03BB04
ATC
tiotropium bromide; inhalant
2.6
13.5
86
361
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
3.0
13.5
61
214
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
6.5
13.3
22
35
ZX108
NOMESCO Finland
Inhalation
14.1
13.3
22
16
XF622
NOMESCO Finland
Measurement of minute volume of heart
40.9
13.2
16
*
L04AD01
ATC
ciclosporin; systemic
6.1
13.1
23
39
N18.8
ICD-10 Finland
Other chronic renal failure
5.2
13.0
27
54
205
Kela drug reimbursment
Chronic hypertension
1.9
12.8
210
1281
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.5
12.8
90
396
C07AB03
ATC
atenolol; systemic
3.2
12.7
52
172
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.1
12.6
143
767
I20.09
ICD-10 Finland
Unstable angina
3.2
12.6
50
162
XF614
NOMESCO Finland
Measurement of pulmonary artery pressure
+∞
12.5
12
*
ARB
HP
Catheter ablation of arrhythmia: Cutiing or modification of the AV node
+∞
12.5
12
*
4254A
ICD-9 Finland
Cardiomyopathy, Other primary cardiomyopathies
+∞
12.5
12
*
FXL00
NOMESCO Finland
Insertion and use of extra-, para- or intracorporeal VAD
+∞
12.5
12
*
I41.8*D86.8
ICD-10 Finland
Sarcoid myocarditis
+∞
12.5
12
*
FPG42
NOMESCO Finland
Replacement of electrode(s) in transvenous cardioverter-defibrillator
+∞
12.5
12
*
4259X
ICD-9 Finland
Cardiomyopathy, Secondary cardiomyopathy, unspecified
+∞
12.5
12
*
FPJ04
NOMESCO Finland
Revision of pacemaker generator with atrial and ventricular electrodes
+∞
12.5
12
*
K83
ICPC
Heart valve disease NOS
132.2
12.5
13
*
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
3.8
12.4
38
104
A10BK03
ATC
empagliflozin; oral
2.4
12.3
89
397
I71.2
ICD-10 Finland
Thoracic aortic aneurysm, without mention of rupture
5.8
12.0
22
39
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
2.8
11.9
62
235
A11CC03
ATC
alfacalcidol; systemic
5.5
11.9
23
43
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
3.0
11.9
54
190
E87.5
ICD-10 Finland
Hyperkalaemia
6.0
11.9
21
36
Z50.0
ICD-10 Finland
Cardiac rehabilitation
12.8
11.7
20
16
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
3.3
11.6
45
144
FPJ00
NOMESCO Finland
Revision of pacemaker pulse generator or electrode
+∞
11.5
11
*
I33.0
ICD-10 Finland
Acute and subacute infective endocarditis
+∞
11.5
11
*
742, ,
NOMESCO Finland
+∞
11.5
11
*
XFP02, ,
NOMESCO Finland
+∞
11.5
11
*
73
HP
Initial pacemaker installation
+∞
11.5
11
*
I48.4
ICD-10 Finland
Atypical atrial flutter
+∞
11.5
11
*
AK1
HP
HTX (heart transplant)
+∞
11.5
11
*
FM1AD
NOMESCO Finland
CT of heart
121.9
11.5
12
*
N19
ICD-10 Finland
Unspecified kidney failure
4.0
11.4
32
82
AA1AD
NOMESCO Finland
CT of head and brain
1.8
11.2
215
1369
3AC01, ,
NOMESCO Finland
13.0
11.2
19
15
B01AF01
ATC
rivaroxaban; oral
2.3
11.2
90
420
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
3.2
11.2
44
142
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
2.3
11.1
90
421
I49.8
ICD-10 Finland
Other specified cardiac arrhythmias
5.1
11.1
23
46
H03BB01
ATC
carbimazole; oral
3.7
11.0
35
98
I34.0
ICD-10 Finland
Mitral (valve) insufficiency
44.0
10.9
13
*
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
2.5
10.9
72
307
R50.9
ICD-10 Finland
Fever, unspecified
2.1
10.9
115
598
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
5.2
10.8
22
43
G47.3
ICD-10 Finland
Sleep apnoea
1.9
10.8
171
1024
ZXE50
NOMESCO Finland
More than nine and less than 12 hours
10.8
10.8
20
19
R04.0
ICD-10 Finland
Epistaxis
2.6
10.8
63
253
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.4
10.6
75
331
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
10.2
10.6
20
20
E05.89
ICD-10 Finland
Other thyrotoxicosis
111.6
10.4
11
*
FPG04
NOMESCO Finland
Insertion of internal defibrillator, atrial and chamber electrode
+∞
10.4
10
*
FPE37
NOMESCO Finland
Implantation of biventricular cardioverter-defibrillator with atrial and ventricular electrodes
+∞
10.4
10
*
I42.5
ICD-10 Finland
Other restrictive cardiomyopathy
+∞
10.4
10
*
R01.1
ICD-10 Finland
Cardiac murmur, unspecified
4.8
10.3
23
49
C02DE01, ,
ATC
13.4
10.2
17
13
R53
ICD-10 Finland
Malaise and fatigue
1.8
10.2
167
1010
ZXM00
NOMESCO Finland
Intraoperative use of ultrasonographic imaging
10.2
10.1
19
19
B01AB05
ATC
enoxaparin; parenteral
1.7
10.0
220
1452
I49.4
ICD-10 Finland
Other and unspecified premature depolarization
7.8
10.0
22
29
I25.2
ICD-10 Finland
Old myocardial infarction
2.8
9.9
51
192
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
3.3
9.9
38
121
J01DB01
ATC
cefalexin; oral
1.8
9.8
565
4793
J01FF01
ATC
clindamycin; systemic
1.8
9.8
186
1174
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
3.1
9.8
42
143
E11.00
ICD-10 Finland
Non-insulin dependent diabetes diabetic hypoglycaemic coma
3.7
9.7
31
87
N18.0
ICD-10 Finland
End-stage renal disease
13.6
9.7
16
12
I20.90
ICD-10 Finland
Angina pectoris, unspecified
3.4
9.7
34
102
TFC99
NOMESCO Finland
Catheterisation of heart with other procedure
55.8
9.7
11
*
I25.0
ICD-10 Finland
Atherosclerotic cardiovascular disease, so described
2.9
9.6
45
161
J01CA04
ATC
amoxicillin; systemic
1.8
9.5
549
4635
FEB10
NOMESCO Finland
Decompression and drainage of pericardium
101.3
9.4
10
*
FM1CD
NOMESCO Finland
Very extensive CT of heart
101.3
9.4
10
*
N02AX02
ATC
tramadol; systemic, rectal
1.6
9.4
303
2204
FKD10
NOMESCO Finland
Replacement of mitral valve using biological prosthesis
+∞
9.4
9
*
XF406
NOMESCO Finland
High resolution ECG
+∞
9.4
9
*
FMD10
NOMESCO Finland
Replacement of aortic valve using biological prosthesis
+∞
9.4
9
*
Z95.8
ICD-10 Finland
Presence of other cardiac and vascular implants and grafts
+∞
9.4
9
*
TK830
NOMESCO Finland
Ultrafiltration
+∞
9.4
9
*
APS
HP
Ventricular septal alcohol ablation (septic vascular embolization)
+∞
9.4
9
*
42798
ICD-8 Finland
Symptomatic heart disease, Alia arrhytmia definita
+∞
9.4
9
*
63
HP
Cardiac muscle biopsy
+∞
9.4
9
*
ASB
HP
Insertion of a biventricular physiological pacemaker DDD (R)
+∞
9.4
9
*
42508
ICD-8 Finland
Cardiomyopathy, Alia definita
+∞
9.4
9
*
I34.9
ICD-10 Finland
Nonrheumatic mitral valve disorder, unspecified
+∞
9.4
9
*
FPH00
NOMESCO Finland
Transvenous extraction of transvenous cardiac pacemaker or cardioverter-defibrillator
+∞
9.4
9
*
I48.3
ICD-10 Finland
Typical atrial flutter
+∞
9.4
9
*
Z82.7
ICD-10 Finland
Family history of congenital malformations, deformations and chromosomal abnormalities
22.0
9.4
13
6
WX002
NOMESCO Finland
Sedation and analgesia
1.9
9.3
141
829
FN1CC
NOMESCO Finland
Very extensive angiography of heart and/or coronary arteries
7.4
9.3
21
29
KA1AE
NOMESCO Finland
Kidney ultrasound examination
3.7
9.1
28
77
Z49.1
ICD-10 Finland
Extracorporeal dialysis
10.2
9.1
17
17
J01MA12
ATC
levofloxacin; systemic
1.9
9.0
136
798
C03EA01
ATC
hydrochlorothiazide and potassium-sparing agents; oral
2.0
9.0
109
594
XF409
NOMESCO Finland
Other special ECG
37.2
9.0
11
*
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.5
9.0
60
257
R11
ICD-10 Finland
Nausea and vomiting
2.4
9.0
65
289
A10BH05
ATC
linagliptin; oral
3.0
9.0
40
139
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.6
8.9
290
2106
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
2.8
8.9
44
162
FL1AC
NOMESCO Finland
Left cardioangiography
8.1
8.9
19
24
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
1.7
8.9
180
1155
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
3.5
8.9
30
88
E78.5
ICD-10 Finland
Hyperlipidaemia, unspecified
2.1
8.8
82
406
FPW96
NOMESCO Finland
Other operation for arhythmia or disturbance of impulse propagation
50.6
8.7
10
*
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
2.2
8.6
78
382
B01AF03
ATC
edoxaban; oral
11.8
8.6
15
13
PD5BD
NOMESCO Finland
Extensive CT of aorta
10.2
8.6
16
16
I45.6
ICD-10 Finland
Pre-excitation syndrome
91.1
8.4
9
*
WX722
NOMESCO Finland
PEEP
2.9
8.4
39
139
I44.0
ICD-10 Finland
Atrioventricular block, first degree
12.9
8.4
14
11
C10AA05
ATC
atorvastatin; oral
1.6
8.4
310
2314
GA1AE
NOMESCO Finland
Ultrasound examination of thorax
4.1
8.4
23
58
I34.2
ICD-10 Finland
Nonrheumatic mitral (valve) stenosis
+∞
8.3
8
*
FPH20
NOMESCO Finland
Removal of epicardial pacemaker or cardioverter-defibrillator
+∞
8.3
8
*
42792
ICD-8 Finland
Symptomatic heart disease, Fibrillatio auricularis
+∞
8.3
8
*
FPJ21
NOMESCO Finland
Revision of cardioverter-defibrillator with ventricular electrode
+∞
8.3
8
*
FMD00
NOMESCO Finland
Replacement of aortic valve using mechanical prosthesis
+∞
8.3
8
*
FQA00
NOMESCO Finland
Orthotopic transplantation of heart
+∞
8.3
8
*
I46.9
ICD-10 Finland
Cardiac arrest, unspecified
+∞
8.3
8
*
FM1JR
NOMESCO Finland
Heart, extensive metabolic PET with CT
+∞
8.3
8
*
R2110
NOMESCO Finland
Giving the first information
2.8
8.3
42
157
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
14.7
8.2
13
9
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
2.8
8.1
39
142
FN1CD
NOMESCO Finland
Very extensive CT of coronary arteries
22.3
8.0
11
5
5AB14, ,
NOMESCO Finland
22.3
8.0
11
5
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
2.9
8.0
38
137
WX730
NOMESCO Finland
Conventional respirator
7.4
8.0
18
25
C09AA02
ATC
enalapril; systemic
1.8
8.0
140
859
I21.40
ICD-10 Finland
Acute subendocardial infarction no detected stenosis of the coronary artery
3.8
8.0
24
65
K04
ICPC
Palpitations/awareness of heart
3.2
7.9
31
100
M01AE01
ATC
ibuprofen; systemic, rectal
0.6
7.9
497
5652
GD1BA
NOMESCO Finland
Extensive X-ray examination of thorax
11.0
7.8
14
13
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
2.9
7.8
37
134
KA1MN
NOMESCO Finland
Glomerular filtration rate (GFR) Isotope mesurement
15.2
7.7
12
8
C01BB02
ATC
mexiletine; systemic
45.5
7.7
9
*
C10AA03
ATC
pravastatin; oral
2.3
7.7
60
276
FN1CB
NOMESCO Finland
Coronary flow reserve measurement with pressure wire
3.8
7.7
23
62
A02BC02
ATC
pantoprazole; systemic
1.6
7.7
462
3825
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.6
7.7
336
2592
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
2.1
7.6
79
407
Y0399
ICD-8 Finland
Investigation of circulatory system
8.2
7.6
16
20
FPK00
NOMESCO Finland
Implantation of electrocardiograph with loop recorder
18.6
7.6
11
6
ZXD00
NOMESCO Finland
Emergency procedure
3.6
7.6
25
72
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
3.5
7.6
26
77
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.8
7.5
112
653
UJF92
NOMESCO Finland
Capsular endoscopy
4.3
7.5
19
45
M01AH05
ATC
etoricoxib; oral
0.6
7.5
267
3453
Z01.8
ICD-10 Finland
Other specified special examinations
1.7
7.4
147
934
I21.49
ICD-10 Finland
Acute subendocardial infarction unspecified coronary artery status
2.6
7.4
43
173
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
3.0
7.3
31
105
FKD00
NOMESCO Finland
Replacement of mitral valve using mechanical prosthesis
+∞
7.3
7
*
FXD00
NOMESCO Finland
Use of ECHLA without concurrent surgical procedure
+∞
7.3
7
*
FXF00
NOMESCO Finland
Decannulation after ECHLA or ECLA
+∞
7.3
7
*
AS2
HP
Ventricular pacemaker insertion VVI (R)
+∞
7.3
7
*
I42.4
ICD-10 Finland
Endocardial fibroelastosis
+∞
7.3
7
*
FKC96
NOMESCO Finland
Other repair of mitral valve for insufficiency
+∞
7.3
7
*
4271A
ICD-9 Finland
Cardiac dysrhythmias, Paroxysmal ventricular tachycardia
+∞
7.3
7
*
WX902
NOMESCO Finland
External defibrillation of heart
+∞
7.3
7
*
FXM00
NOMESCO Finland
Removal of extra-, para- or intracorporeal VAD
+∞
7.3
7
*
FJA00
NOMESCO Finland
Biopsy of right ventricle
+∞
7.3
7
*
FME20
NOMESCO Finland
Transvenous aortic valve replacement via femoral artery
+∞
7.3
7
*
I20.81
ICD-10 Finland
Other angina pectoris stenosed coronary artery
2.3
7.2
52
232
FP3A5
NOMESCO Finland
ECG with work load test
30.3
7.2
9
*
FWD00
NOMESCO Finland
Reoperation for superficial haemorrhage in surgery of heart and major thoracic vessels
12.2
7.1
12
10
103
Kela drug reimbursment
Diabetes, insulin-treated
1.6
7.1
194
1339
R60.0
ICD-10 Finland
Localized oedema
1.9
7.0
89
492
J44.1
ICD-10 Finland
Chronic obstructive pulmonary disease with acute exacerbation, unspecified
3.5
7.0
24
71
N05BA01
ATC
diazepam; systemic, rectal
1.9
7.0
91
508
UJF32
NOMESCO Finland
Coloscopy
1.6
6.9
183
1250
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
2.4
6.9
48
211
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
3.7
6.8
21
58
62
HP
Catheterization and pressure measurement of the right side of the heart
40.4
6.8
8
*
J81
ICD-10 Finland
Pulmonary oedema
40.4
6.8
8
*
WX882
NOMESCO Finland
High dependency care
3.3
6.8
25
78
L04AX01
ATC
azathioprine; systemic
2.9
6.7
30
105
WX402
NOMESCO Finland
General anaesthesia
1.7
6.7
149
974
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
3.1
6.7
27
89
D86.0
ICD-10 Finland
Sarcoidosis of lung
6.5
6.7
16
25
PD4DE
NOMESCO Finland
Lower extremity artery ultrasound examination with Doppler method
4.1
6.7
18
45
R1410
NOMESCO Finland
Drawing up a rehabilitation plan
10.1
6.5
12
12
D86.8
ICD-10 Finland
Sarcoidosis of other and combined sites
10.1
6.5
12
12
PG5DE
NOMESCO Finland
Ultrasound examination of injection gate to artery or vein with Doppler method
70.5
6.4
7
*
ZST00
NOMESCO Finland
Procedure related to previous procedure classified in chapter T
70.5
6.4
7
*
2BD01, ,
NOMESCO Finland
70.5
6.4
7
*
I47.0
ICD-10 Finland
Re-entry ventricular arrhythmia
70.5
6.4
7
*
I27.2
ICD-10 Finland
Other secondary pulmonary hypertension
70.5
6.4
7
*
N17.8
ICD-10 Finland
Other acute renal failure
7.5
6.4
14
19
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.5
6.4
229
1674
A10AC01
ATC
insulin (human); parenteral
2.2
6.3
52
245
61
HP
Catheterization and pressure measurement of the left side of the heart
5.6
6.3
17
31
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
11.1
6.3
11
10
FPE24
NOMESCO Finland
Implantation of biventricular cardiac pacemaker, ventricular electrodes, CRT-P (VVIR)
+∞
6.3
6
*
TFC20
NOMESCO Finland
Catheterisation of both sides of heart
+∞
6.3
6
*
FXG00
NOMESCO Finland
Insertion and use of IABP
+∞
6.3
6
*
XF645
NOMESCO Finland
Heart ultrasound examination with load test
+∞
6.3
6
*
4289X
ICD-9 Finland
Heart failure, unspecified
+∞
6.3
6
*
FPE10
NOMESCO Finland
Implantation of transvenous cardiac pacemaker with atrial electrode
+∞
6.3
6
*
AQ2
HP
Electrophysiological electroanatomical examination
+∞
6.3
6
*
342
Kela drug reimbursment
Dronedarone
+∞
6.3
6
*
FPB22
NOMESCO Finland
Transvenous radiofrequency ablation of aberrant pathway or focus of heart
+∞
6.3
6
*
AT7
HP
Replacing the pacemaker VVI (R) S
+∞
6.3
6
*
I51.7
ICD-10 Finland
Cardiomegaly
+∞
6.3
6
*
TFP44
NOMESCO Finland
Ablation treatment of typical atrial flutter
+∞
6.3
6
*
TFP40
NOMESCO Finland
Ablation treatment for a-v node re-entry activation
+∞
6.3
6
*
42700
ICD-8 Finland
Symptomatic heart disease, Congestive heart failure
+∞
6.3
6
*
TFP52
NOMESCO Finland
Ablation treatment of ventricular tachycardia due to structural heart defect
+∞
6.3
6
*
I10
ICD-10 Finland
Essential (primary) hypertension
1.5
6.2
430
3590
T92
ICPC
Gout
3.6
6.2
20
57
C09AA01
ATC
captopril; oral
5.4
6.2
17
32
ZXE02
NOMESCO Finland
Procedure duration 10 to 19 minutes
2.6
6.0
35
141
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.6
6.0
187
1323

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
536
1380
12.02
237.16
10.7
1.8
2351.08
505.97
ng/l
16.78
519
1127
254
741
4.73
81.57
4.6
2.2
21.11
23.79
%
2.64
246
690
275
863
4.52
80.15
4.5
2.2
12.49
13.68
umol/l
1.96
262
798
260
809
4.45
76.13
4.5
2.2
2.33
2.31
g/l
0.19
248
745
170
387
5.43
73.00
5.5
1.9
29.97
5.87
ug/l
5.21
159
334
480
2555
3.59
59.19
43.2
6.0
1.61
1.09
inr
43.26
414
2049
258
1020
3.37
50.16
8.8
2.8
651.52
436.64
ng/l
0.42
253
787
237
945
3.24
44.70
10.9
3.4
0.81
0.82
mmol/l
0.11
230
885
392
2100
2.88
42.94
8.9
2.8
83.52
78.78
ng/l
0.05
332
1536
209
818
3.18
40.15
5.6
1.9
32.00
28.68
s
8.92
203
802
105
268
4.41
38.04
4.9
3.6
4.00
4.62
pmol/l
7.76
100
242
140
480
3.37
32.94
20.2
7.4
—
—
—
0
0
287
1457
2.60
32.74
3.7
2.1
3.25
2.83
mg/l
1.53
256
1228
181
746
2.90
30.86
11.8
5.0
1.10
1.00
mmol/l
3.62
167
694
81
198
4.48
30.83
5.0
1.8
22.61
20.61
s
1.09
76
181
137
482
3.27
30.78
2.3
3.1
64.64
67.40
g/l
4.00
130
444
90
243
4.09
30.05
1.9
1.8
1.62
1.48
g/l
0.63
79
211
158
618
2.99
29.52
16.2
7.0
-0.22
0.71
mmol/l
1.66
138
507
145
541
3.10
29.43
6.6
2.9
7.37
7.38
ph
0.94
85
303
143
530
3.11
29.35
6.6
2.9
1.17
1.96
mmol/l
1.93
129
450
159
628
2.96
29.16
16.5
6.9
11.78
12.80
kpa
1.74
154
605
159
628
2.96
29.16
16.6
6.9
4.90
5.12
kpa
1.59
153
604
157
623
2.94
28.50
16.4
7.0
7.42
7.41
ph
0.58
76
329
36
45
8.37
27.08
1.6
1.3
12423.00
133578.67
e6/l
1.11
21
24
292
1629
2.33
25.73
6.7
3.8
—
—
—
0
0
36
48
7.84
25.67
1.6
1.3
673.80
22235.43
e6/l
0.53
25
30
176
785
2.64
25.27
16.6
6.2
103.92
104.06
mmol/l
0.13
176
785
392
2490
2.25
25.05
4.9
2.7
151.42
148.46
ug/l
0.08
371
2285
35
47
7.77
24.80
1.5
1.3
—
—
—
0
0
305
1779
2.23
23.69
4.3
2.1
236.81
208.08
u/l
0.22
294
1680
132
529
2.83
23.20
18.6
7.7
119.19
122.31
g/l
0.80
132
514
149
648
2.63
22.28
2.9
2.5
1.85
1.77
%
0.32
139
574
31
15
21.52
21.41
4.3
3.1
—
—
—
0
0
32
48
6.93
20.55
1.5
1.6
—
—
—
0
0
40
76
5.51
20.35
1.5
1.1
2.44
2.67
u/ml
0.13
27
33
28
37
7.83
20.07
1.3
1.3
—
—
—
0
0
50
117
4.52
20.00
4.1
1.8
10.89
11.33
mg/l
0.12
43
110
396
2673
2.06
19.94
19.4
10.1
0.00
0.00
e9/l
0.43
330
2167
33
54
6.35
19.53
2.7
2.1
—
—
—
0
0
441
3140
2.03
18.64
12.0
7.2
14.49
11.32
umol/l
6.95
428
2984
403
2794
1.99
18.20
15.4
5.5
1.20
1.21
mmol/l
5.30
386
2550
481
3555
2.05
18.03
12.3
4.2
6.86
6.71
mmol/l
0.72
461
3364
298
1867
2.01
17.93
7.7
3.8
7.39
7.40
ph
0.74
227
1319
435
3127
1.98
17.35
15.0
6.2
1.20
1.22
mmol/l
6.20
380
2664
35
69
5.28
17.09
1.4
1.2
—
—
—
0
0
305
1967
1.95
16.54
11.4
6.0
—
—
—
0
0
414
2961
1.93
16.37
11.8
6.1
0.62
0.59
e9/l
1.85
362
2478
44
109
4.23
16.36
1.8
1.4
—
—
—
0
0
136
648
2.35
16.36
2.3
1.6
—
—
—
0
0
127
589
2.40
16.23
2.3
2.4
0.19
0.21
g/l
2.85
117
560
425
3076
1.92
16.10
12.3
6.3
0.19
0.20
e9/l
0.48
379
2627
414
2971
1.92
16.10
11.8
6.1
0.04
0.04
e9/l
0.38
361
2489
249
1516
1.98
15.84
3.7
2.6
394.84
343.12
umol/l
9.68
225
1316
204
1176
2.02
15.03
6.5
1.6
1.52
1.46
mg/l
0.07
156
936
415
3025
1.87
14.91
11.9
6.2
1.71
1.95
e9/l
3.91
367
2609
140
702
2.23
14.83
2.5
3.0
8.92
8.49
umol/l
0.13
128
636
155
812
2.16
14.71
2.9
2.0
—
—
—
0
0
382
2727
1.85
14.53
6.2
4.8
34.90
35.78
g/l
2.27
365
2547
293
1931
1.87
14.36
3.5
3.5
51.20
32.30
u/l
0.93
276
1819
40
102
4.09
14.32
1.8
1.2
360.84
243.20
u/ml
1.36
31
60
29
57
5.26
14.21
2.1
2.6
20.54
32.84
iu/ml
—
5
8
446
3374
1.83
13.71
13.8
10.2
4.36
4.07
e9/l
2.08
392
2890
39
101
4.02
13.68
1.8
1.4
148.44
159.48
au/ml
—
9
26
27
52
5.35
13.52
1.0
1.2
—
—
—
0
0
379
2738
1.80
13.50
12.2
6.2
2.70
2.94
%
1.47
360
2533
250
1591
1.87
13.50
7.0
3.8
71.73
92.97
%
21.24
244
1562
379
2739
1.80
13.47
12.4
6.3
9.08
8.98
%
0.29
360
2536
379
2746
1.80
13.29
12.2
6.3
0.66
0.69
%
0.48
360
2531
38
99
4.00
13.22
7.8
3.4
—
—
—
0
0
92
404
2.46
13.14
2.0
2.6
—
—
—
0
0
77
313
2.63
12.91
25.2
9.4
15.36
16.00
%
1.24
77
296
57
197
3.05
12.90
3.0
3.8
42.33
108.38
mg/l
0.59
51
172
57
197
3.05
12.90
3.0
3.8
55.30
40.86
mg/l
0.47
51
171
105
497
2.30
12.67
2.5
2.5
74.63
67.35
e9/l
0.81
72
360
382
2804
1.76
12.55
12.3
6.2
23.75
27.82
%
11.38
363
2633
58
209
2.93
12.20
1.6
2.8
9.75
10.92
g/l
1.21
52
186
267
1779
1.79
12.15
3.9
3.1
0.42
0.44
e6/l
0.07
209
1313
24
46
5.36
12.08
2.5
1.6
9.98
10.92
%
0.48
24
46
22
21
10.77
11.82
1.1
1.1
7.40
7.36
ph
0.20
13
15
26
55
4.87
11.73
1.1
1.3
—
—
—
0
0
372
2748
1.73
11.62
12.2
6.2
61.29
56.96
%
10.48
360
2606
295
2045
1.75
11.57
4.2
3.2
84.79
99.79
e6/l
0.15
238
1576
51
180
2.97
11.14
2.8
3.7
17.79
4.08
ratio
0.38
27
110
228
1490
1.77
10.85
3.5
2.3
—
—
—
0
0
285
1984
1.72
10.84
3.4
2.4
—
—
—
0
0
216
1400
1.77
10.52
3.2
2.5
4.53
4.51
e6/l
0.01
201
1272
32
88
3.76
10.35
10.0
3.7
2.94
1.91
mmol/l
0.94
22
59
44
151
3.04
10.09
1.5
1.4
1.19
1.17
g/l
0.12
39
145
81
378
2.29
10.05
1.6
1.5
—
—
—
0
0
315
2289
1.66
9.97
5.0
3.8
42.81
102.30
e6/l
1.64
241
1625
31
86
3.72
9.91
2.3
2.4
—
—
—
0
0
23
51
4.62
9.83
10.0
3.4
11.88
11.50
index
0.10
17
30
261
1812
1.69
9.80
10.4
6.4
—
—
—
0
0
39
128
3.16
9.65
2.5
3.9
—
—
—
0
0
107
573
2.02
9.34
2.2
1.5
—
—
—
0
0
42
147
2.97
9.32
7.6
3.2
2.30
2.18
index
0.05
27
78
16
14
11.66
9.10
1.1
1.0
—
—
—
0
0
16
14
11.66
9.10
1.1
1.2
—
—
—
0
0
546
4645
1.71
8.72
14.3
8.3
82.58
80.42
u/l
0.26
528
4355
41
148
2.88
8.63
1.5
1.4
0.23
0.23
g/l
0.08
36
142
35
117
3.09
8.42
4.3
2.2
123.76
131.09
g/l
0.91
29
92
187
1230
1.70
8.38
2.9
2.7
521.69
566.48
mosm/kgh2o
2.28
167
1069
44
169
2.71
8.26
1.7
1.2
—
—
—
0
0
362
2814
1.57
8.15
3.6
2.7
—
—
estimate
—
0
0
39
143
2.83
7.99
5.6
3.6
4.05
3.89
mmol/l
1.17
39
143
171
1119
1.69
7.74
3.5
2.9
1.02
1.03
e6/l
0.01
86
610
256
1863
1.58
7.52
3.5
2.6
57.14
61.67
u/l
0.53
242
1712
470
3923
1.56
7.39
6.0
4.5
37.83
1994.52
e6/l
1.59
12
56
129
791
1.77
7.35
2.2
1.7
—
—
—
0
0
48
206
2.42
7.21
1.3
1.2
—
—
—
0
0
71
360
2.08
7.16
2.0
1.8
1.34
1.58
g/l
0.35
64
334
118
712
1.78
7.09
1.3
1.3
344.00
525.30
titre
1.09
20
151
158
1038
1.67
6.98
3.5
3.0
2.60
1.97
e6/l
0.42
71
527
34
125
2.80
6.95
1.3
1.1
—
—
—
0
0
72
372
2.04
6.91
5.5
3.2
7.41
7.42
ph
0.64
63
310
283
2147
1.52
6.73
4.4
3.7
2.35
2.36
mmol/l
0.42
256
1932
90
509
1.88
6.65
2.6
2.3
435.70
373.72
nmol/l
0.93
84
482
12
12
10.14
6.55
1.8
1.2
34.58
28.17
s
1.36
12
12
17
30
5.78
6.48
12.2
3.6
1.18
0.93
index
0.59
17
30
113
693
1.75
6.40
2.2
1.5
—
—
—
0
0
243
1802
1.52
6.35
2.0
1.6
20.02
20.45
nmol/l
0.16
217
1495
80
444
1.90
6.26
2.3
2.8
10.50
11.04
g/l
0.56
73
410
6
0
+∞
6.26
2.2
0.0
—
—
—
0
0
548
4813
1.57
6.20
41.8
17.8
14.15
13.60
%
12.80
541
4740
12
15
8.11
5.85
1.1
1.0
179.67
136.55
iu/ml
0.39
12
15
93
564
1.74
5.46
1.8
1.6
—
—
—
0
0
26
97
2.74
5.22
1.3
1.8
0.59
0.80
g/l
0.44
19
79
24
86
2.85
5.19
3.6
3.1
3.68
4.12
e9/l
0.55
24
86
16
46
3.53
4.91
1.3
1.1
—
—
—
0
0
15
42
3.63
4.78
1.3
1.1
—
—
—
0
0
11
17
6.55
4.78
1.7
3.1
0.63
0.59
mmol/l
0.61
11
17
92
583
1.66
4.61
3.0
2.4
297.93
36.99
u/l
0.51
80
486
76
458
1.74
4.57
4.1
3.5
—
—
—
0
0
9
11
8.27
4.57
1.0
1.0
—
—
—
0
0
20
70
2.91
4.52
1.5
1.5
—
—
—
0
0
20
70
2.91
4.52
1.5
1.5
—
—
—
0
0
20
70
2.91
4.52
1.5
1.5
—
—
—
0
0
20
70
2.91
4.52
1.5
1.5
—
—
—
0
0
168
1239
1.46
4.28
8.7
4.8
—
—
—
0
0
29
127
2.34
4.25
1.6
1.7
2.53
4.27
iu/l
—
10
51
266
2147
1.38
4.04
3.5
3.4
77.78
37.03
mg/l
1.47
194
1349
275
2237
1.37
3.96
3.4
3.3
7.35
7.91
mmol/l
1.43
223
1881
620
5757
1.53
3.94
34.9
13.9
27.07
27.13
mg/l
0.01
543
4637
154
1137
1.45
3.88
1.6
1.5
2.67
2.63
g/l
0.08
97
646
26
114
2.33
3.82
4.7
2.8
58.07
58.07
%
0.00
26
114
11
24
4.64
3.75
8.4
1.9
705.27
1845.58
u/ml
0.60
11
24
489
4368
1.37
3.74
5.4
3.9
15.40
14.87
pmol/l
4.42
466
3918
80
517
1.62
3.72
5.7
5.2
0.32
0.07
%
0.42
25
134
25
109
2.34
3.72
1.2
1.5
16.92
30.50
u/l
0.58
19
91
27
122
2.26
3.71
2.0
1.7
—
—
—
0
0
12
30
4.05
3.60
1.1
1.3
—
—
—
0
0
117
831
1.49
3.58
1.2
1.2
—
—
—
0
0
267
2191
1.35
3.55
4.3
4.0
14.24
5.57
mg/mmol
1.63
184
1348
74
476
1.62
3.52
6.0
3.9
1.21
1.23
mmol/l
1.44
63
404
78
509
1.60
3.50
5.2
4.7
0.24
0.61
%
2.21
27
157
56
340
1.70
3.33
1.4
1.6
—
—
—
0
0
368
3192
1.31
3.23
4.7
3.7
0.05
0.01
estimate
0.43
86
626
363
3143
1.31
3.22
4.7
3.7
0.00
0.00
estimate
-0.00
95
662
22
99
2.26
3.09
4.3
3.0
11.10
7.74
pmol/l
0.83
22
99
5
5
10.06
2.98
1.8
5.6
4.10
5.26
kpa
—
5
5
364
3181
1.29
2.91
4.8
3.8
0.00
7.73
estimate
1.08
95
679
21
419
0.49
2.80
1.2
1.4
—
—
—
0
0
78
538
1.50
2.77
5.7
4.7
0.48
0.98
%
1.68
27
170
97
700
1.45
2.75
1.8
1.5
—
—
—
0
0
75
514
1.51
2.74
5.7
4.9
0.04
0.11
%
0.71
24
149
17
72
2.39
2.74
1.2
1.3
0.70
25.98
nmol/l
0.49
17
67
214
1758
1.31
2.70
3.5
3.1
—
—
—
0
0
12
43
2.82
2.65
1.0
1.0
—
—
—
0
0
83
591
1.46
2.53
2.8
1.3
—
—
—
0
0
291
2507
1.27
2.50
4.4
3.3
6.30
6.24
ph
0.39
158
1393
15
63
2.41
2.47
1.1
1.1
—
—
—
0
0
213
1767
1.29
2.47
5.1
3.8
0.00
0.01
estimate
0.69
85
611
24
125
1.95
2.38
1.2
1.1
—
—
—
0
0
325
2849
1.25
2.37
2.3
2.1
93.16
94.46
pmol/l
0.20
168
1478
39
240
1.66
2.27
1.5
1.6
0.40
0.36
mg/l
0.09
16
117
15
66
2.30
2.25
1.2
1.2
—
—
—
0
0
12
48
2.53
2.19
1.2
1.2
—
—
—
0
0
8
24
3.36
2.18
1.1
1.0
—
—
—
0
0
17
81
2.13
2.14
2.3
2.2
—
—
—
0
0
12
49
2.47
2.11
1.0
1.0
—
—
—
0
0
24
131
1.86
2.10
1.3
1.3
247.00
250.75
miu/ml
—
6
56
6
15
4.02
2.04
3.0
1.7
—
—
—
0
0
36
225
1.63
2.00
1.7
1.7
16.86
7.61
iu/ml
—
7
57
7
21
3.36
1.97
6.1
4.8
8.16
6.86
mmol/l
—
7
21
129
1033
1.30
1.94
1.9
1.7
1382.13
1123.69
nmol/l
2.16
101
765
13
58
2.26
1.91
2.1
2.4
2.42
0.69
g/24h
—
8
33
276
2422
1.23
1.89
2.1
2.2
—
—
—
0
0
156
1286
1.27
1.87
2.9
3.1
2.46
2.45
mmol/l
0.31
138
1163
199
1689
1.25
1.86
1.4
1.4
—
—
—
0
0
302
2688
1.21
1.77
3.3
2.3
76.40
78.71
nmol/l
0.76
273
2369
12
54
2.24
1.74
1.5
1.3
—
—
—
0
0
12
55
2.20
1.68
1.5
1.3
6.30
6.93
g/l
—
7
41
564
5351
1.24
1.66
6.5
4.9
2.11
1.94
mu/l
2.30
538
4817
7
25
2.82
1.65
3.1
2.6
1537.14
1604.50
ml
—
7
20
32
206
1.58
1.62
2.4
4.0
249.90
188.39
mg/l
0.38
21
93
5
14
3.59
1.62
4.8
2.6
—
—
—
0
0
191
1638
1.23
1.61
3.2
3.0
0.00
0.06
—
6
47
6
20
3.02
1.58
7.2
5.0
17.13
16.54
%
—
6
20
24
381
0.62
1.54
1.7
1.7
3.09
3.47
mmol/l
0.92
18
280
5
15
3.35
1.52
1.0
1.8
—
—
—
0
0
41
284
1.47
1.51
5.8
3.2
—
—
—
0
0
11
52
2.13
1.45
1.1
2.3
—
—
—
0
0
14
73
1.94
1.44
1.4
1.5
28.29
29.15
ng/l
0.04
14
73
6
22
2.74
1.43
1.0
1.1
—
—
—
0
0
632
6103
1.27
1.40
48.3
16.2
139.20
139.72
mmol/l
4.25
620
5954
10
46
2.19
1.40
1.4
2.1
970.60
694.33
mg
—
10
46
13
67
1.96
1.39
1.2
1.3
—
—
nmol/l
—
0
0
575
5500
1.22
1.37
5.7
4.3
1.34
1.30
mmol/l
0.75
540
4976
9
41
2.21
1.37
2.0
2.0
43.28
37.80
%
—
9
41
8
164
0.48
1.37
1.1
1.2
1.01
0.90
g/l
—
8
164
10
47
2.14
1.34
1.1
1.5
—
—
—
0
0
9
42
2.16
1.34
1.6
1.4
82.78
83.05
umol/l
—
9
42
632
6114
1.26
1.30
48.9
16.3
4.04
3.98
mmol/l
7.62
619
5953
141
1646
0.82
1.30
3.3
3.3
0.57
0.75
ug/l
3.15
93
1115
34
235
1.47
1.29
1.4
1.3
—
—
—
0
0
620
5986
1.24
1.29
28.2
12.6
—
—
—
0
0
9
44
2.06
1.27
1.6
2.5
—
—
—
0
0
8
35
2.30
1.27
1.1
1.8
—
—
—
0
0
12
63
1.92
1.23
1.2
1.2
—
—
—
0
0
11
56
1.98
1.22
1.0
1.2
—
—
—
0
0
262
2368
1.17
1.20
4.8
3.7
0.02
0.02
estimate
0.09
88
538
0
33
0.00
1.16
0.0
1.2
—
—
—
0
0
232
2570
0.86
1.16
2.0
1.9
1.47
1.35
mmol/l
0.91
172
2132
8
39
2.06
1.15
1.1
1.1
111.00
115.15
pmol/l
—
8
39
8
153
0.52
1.15
1.1
1.2
1.41
1.51
g/l
—
8
153
10
51
1.97
1.11
3.8
2.5
44.60
34.75
mg/l
—
10
32
16
96
1.68
1.11
1.0
1.1
—
—
—
0
0
56
711
0.77
1.09
2.3
2.3
89.68
119.45
ug/g
0.92
42
555
21
139
1.53
1.01
2.0
2.3
16.64
73.16
ug/min
2.19
11
83
149
1306
1.18
0.99
1.3
1.2
0.93
1.21
u/ml
0.53
38
329
194
2151
0.87
0.96
3.6
3.2
—
—
—
0
0
13
77
1.70
0.95
1.6
2.4
185.13
3990.48
u/l
—
6
27
100
849
1.21
0.95
1.3
1.3
—
—
—
0
0
245
2671
0.88
0.95
5.5
5.7
2.35
2.60
ug/l
0.28
213
2421
16
101
1.60
0.94
1.0
1.1
—
—
—
0
0
578
5593
1.16
0.90
7.6
6.5
40.96
39.42
mmol/mol
3.68
540
5170
33
433
0.75
0.85
1.2
1.5
—
—
—
0
0
64
526
1.24
0.85
3.1
2.4
0.47
0.32
e6/l
0.36
64
501
83
702
1.21
0.84
1.4
1.4
—
—
—
0
0
36
276
1.32
0.82
1.4
1.2
—
—
—
0
0
40
316
1.28
0.75
1.2
1.1
168.11
115.96
u/ml
0.21
14
114
153
1375
1.14
0.75
5.6
3.9
1.02
1.02
kg/l
0.94
109
899
22
300
0.73
0.74
1.8
1.8
—
—
—
0
0
9
56
1.61
0.72
1.0
1.1
—
—
—
0
0
5
27
1.86
0.68
1.0
1.1
—
—
—
0
0
5
27
1.86
0.68
1.0
1.1
—
—
—
0
0
5
27
1.86
0.68
1.0
1.1
—
—
—
0
0
22
164
1.35
0.63
1.0
1.1
—
—
—
0
0
11
71
1.56
0.62
3.6
3.8
—
—
—
0
0
14
199
0.70
0.62
1.1
1.2
—
—
—
0
0
21
156
1.36
0.61
1.5
1.7
9750.79
14353.97
e6/l
0.33
14
103
110
983
1.14
0.60
1.4
1.3
38.32
37.68
iu/ml
0.02
39
298
0
22
0.00
0.59
0.0
3.3
—
34.00
—
0
16
105
937
1.14
0.59
1.2
1.3
5.01
12.58
u/ml
1.48
42
348
10
65
1.55
0.55
1.2
1.2
—
—
—
0
0
181
1676
1.11
0.55
4.2
3.2
0.00
0.00
estimate
0.80
82
537
589
5763
1.12
0.54
6.3
5.1
1.32
1.45
mmol/l
13.57
553
5274
23
293
0.78
0.53
2.7
2.3
0.00
0.01
estimate
—
10
93
63
723
0.86
0.52
3.0
4.9
6.00
24.42
ug/l
1.11
56
599
6
40
1.50
0.51
1.2
1.0
—
—
—
0
0
592
5804
1.11
0.48
6.4
5.2
4.18
4.62
mmol/l
20.70
557
5348
13
177
0.73
0.47
1.2
1.4
275.88
275.80
ug/g
—
8
99
587
5757
1.10
0.46
6.2
5.2
6.20
5.97
mmol/l
3.16
542
5195
12
163
0.73
0.44
1.0
1.1
—
—
—
0
0
20
157
1.28
0.43
1.3
1.1
—
—
—
0
0
55
624
0.87
0.41
6.7
3.9
7.36
7.36
ph
0.02
44
421
8
58
1.38
0.41
2.0
3.2
2.13
2.70
nmol/l
—
8
58
65
578
1.14
0.41
2.1
2.2
0.00
0.03
estimate
0.50
12
120
5
33
1.52
0.41
1.0
1.3
172.40
143.54
nmol/l
—
5
33
0
16
0.00
0.41
0.0
8.1
—
9.01
—
0
16
141
1313
1.09
0.40
1.9
1.7
111111557.70
13573828.72
pmol/l
0.65
117
1083
5
35
1.43
0.39
1.6
1.1
—
—
—
0
0
10
137
0.73
0.39
1.2
1.3
—
—
—
0
0
0
19
0.00
0.39
0.0
1.1
—
—
—
0
0
71
639
1.12
0.38
2.4
2.3
11.40
13.81
nmol/l
1.70
62
578
32
271
1.19
0.38
2.6
3.0
—
—
—
0
0
12
158
0.76
0.37
3.3
4.7
—
—
—
0
0
5
37
1.35
0.37
1.2
1.1
6.98
6.35
ug/l
—
5
31
10
72
1.39
0.37
1.0
1.3
—
—
—
0
0
35
303
1.16
0.33
2.4
3.6
1.02
1.02
ratio
0.64
30
280
10
74
1.36
0.32
1.4
1.7
—
—
—
0
0
66
599
1.11
0.32
1.4
1.6
—
—
—
0
0
634
6407
0.92
0.30
52.3
22.0
133.47
136.33
g/l
4.11
625
6299
31
356
0.87
0.30
1.1
1.4
—
62.95
—
0
35
7
56
1.25
0.29
1.0
1.1
—
—
—
0
0
391
3813
1.06
0.29
3.9
3.2
71.83
53.26
u/l
2.56
369
3539
634
6404
0.92
0.28
52.0
21.9
7.15
6.70
e9/l
2.21
621
6204
634
6404
0.92
0.28
51.8
21.8
4.46
4.51
e12/l
1.36
622
6202
634
6404
0.92
0.28
51.7
21.8
91.74
91.27
fl
1.63
624
6299
634
6404
0.92
0.28
51.6
21.8
30.37
30.44
pg
0.38
624
6298
634
6404
0.92
0.28
54.9
22.2
40.12
40.50
%
0.90
624
6292
22
257
0.85
0.26
1.5
3.8
28.77
112.73
u/ml
1.11
22
252
634
6401
0.92
0.26
51.8
21.9
232.50
247.75
e9/l
5.92
622
6224
35
310
1.14
0.26
2.3
2.3
—
—
—
0
0
5
72
0.69
0.26
1.2
1.2
—
—
—
0
0
9
76
1.19
0.24
1.3
1.1
—
—
—
0
0
25
217
1.16
0.24
1.4
1.8
41.52
38.97
nmol/l
0.24
25
208
10
126
0.79
0.24
1.1
1.2
—
—
—
0
0
627
6212
1.07
0.22
19.8
11.8
29.99
26.18
u/l
0.82
604
5991
7
91
0.77
0.22
3.0
5.9
292.43
376.21
umol/l
—
7
84
0
11
0.00
0.21
0.0
1.5
—
1.29
—
0
5
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
0.02
—
0
10
0
12
0.00
0.21
0.0
1.3
—
71.42
—
0
12
5
43
1.16
0.21
1.2
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
37.80
—
0
5
0
13
0.00
0.21
0.0
2.0
—
16.90
—
0
13
10
80
1.25
0.20
1.0
1.1
—
—
—
0
0
9
115
0.78
0.20
1.2
1.4
—
—
—
0
0
10
81
1.24
0.19
1.0
1.1
—
—
—
0
0
596
5908
1.05
0.17
7.2
5.9
2.40
2.71
mmol/l
15.91
560
5417
22
247
0.89
0.17
1.0
1.1
—
—
—
0
0
21
187
1.13
0.16
1.4
1.8
—
—
—
0
0
30
274
1.10
0.15
2.1
3.8
27.37
4807.65
u/ml
0.74
25
239
11
93
1.19
0.14
1.2
1.8
—
—
—
0
0
633
6293
1.05
0.13
47.4
18.6
95.01
78.06
umol/l
13.11
621
6197
489
4854
1.02
0.09
49.0
18.6
330.43
332.89
g/l
7.49
484
4824
72
745
0.96
0.09
3.6
3.5
4.54
5.13
e9/l
0.32
66
637
5
61
0.82
0.08
1.4
1.5
—
—
—
0
0
14
153
0.91
0.07
1.6
1.3
—
—
—
0
0
14
153
0.91
0.07
1.6
1.3
—
—
—
0
0
14
153
0.91
0.07
1.6
1.3
—
—
—
0
0
13
142
0.91
0.06
1.4
1.3
—
—
—
0
0
23
220
1.05
0.03
7.5
5.0
0.75
0.91
%
1.65
23
205
14
149
0.94
0.03
1.6
1.3
—
—
—
0
0
47
461
1.02
0.02
1.1
1.2
—
—
—
0
0
41
415
0.99
0.00
1.4
1.2
—
—
—
0
0
11
108
1.02
0.00
7.1
7.1
12.64
10.89
mmol/l
1.50
11
94
11
108
1.02
0.00
7.1
7.1
102.27
105.87
mmol/l
0.91
11
94
10
99
1.01
0.00
1.4
1.4
—
—
—
0
0
46
458
1.00
0.00
2.3
2.7
5.84
6.04
ph
1.04
35
311
20
201
0.99
0.00
9.6
9.2
—
—
—
0
0
7
77
0.91
0.00
3.7
2.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
58
0.86
-0.00
1.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
59
0.85
-0.00
1.4
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
0.38
—
0
6
0
5
0.00
-0.00
0.0
8.2
—
0.20
—
0
5
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
6.79
—
0
6
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.2
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint I9_CARDMYOHYP and mortality.

Females

Parameter HR [95% CI] p-value
I9_CARDMYOHYP 2.125 [1.83, 2.47] < 0.001
Birth year 0.993 [0.98, 1.0] 0.105

During the follow-up period (1.1.1998 — 31.12.2019), 446 out of 1326 females with I9_CARDMYOHYP died.

Males

Parameter HR [95% CI] p-value
I9_CARDMYOHYP 2.113 [1.81, 2.47] < 0.001
Birth year 0.988 [0.98, 1.0] 0.012

During the follow-up period (1.1.1998 — 31.12.2019), 581 out of 1732 males with I9_CARDMYOHYP died.

Mortality risk

Mortality risk for people of age

years, who have I9_CARDMYOHYP.

N-year risk Females Males
1 0.224% 0.382%
5 1.246% 2.525%
10 3.069% 6.487%
15 5.663% 11.863%
20 9.796% 20.165%

Relationships between endpoints

Index endpoint: I9_CARDMYOHYP – Cardiomyopathy, Hypertrophic obstructive

GWS hits: 18

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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