Tympanosclerosis

H8_TYMPSCLE

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H74.0 Hospital discharge: ICD-9 — 3850 Cause of death: ICD-10 — H74.0 Cause of death: ICD-9 — 3850 2 out of 7 registries used, show all original rules.	79
4. Check minimum number of events None	79
5. Include endpoints None	79
6. Filter based on genotype QC (FinnGen only)	70

Control definitions (FinnGen only)

Control exclude: H8_MIDDLEMASTOID

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: H74
Name in latin: Tympanosclerosis

NAME	H8_TYMPSCLE
CONTROL_EXCLUDE	H8_MIDDLEMASTOID
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H740
HD_ICD_9	3850
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H740
COD_ICD_9	3850
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Tympanosclerosis based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	655	366	286
Only index persons	602	343	259
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	39.64	44.87	32.79
Only index persons	38.70	43.91	31.80

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	70	45	25
Unadjusted period prevalence (%)	0.01	0.02	0.01
Median age at first event (years)	45.54	45.56	45.50

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
74: Matched controls
740

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

H74.0

ICD-10 Finland

Tympanosclerosis

+∞

78.8

DFF00

NOMESCO Finland

Pure tone audiometry

9.4

17.0

Z01.1

ICD-10 Finland

Examination of ears and hearing

8.2

16.2

H72.0

ICD-10 Finland

Central perforation of tympanic membrane

+∞

16.2

H71

ICD-10 Finland

Cholesteatoma of middle ear

+∞

15.1

DCD00

NOMESCO Finland

Myringoplasty

+∞

15.1

3850A

ICD-9 Finland

Other disorders of middle ear and mastoid, Tympanosclerosis

+∞

14.0

UDC00

NOMESCO Finland

Ear microscopy

9.7

9.8

DCD10

NOMESCO Finland

Tympanoplasty

+∞

9.6

H65.3

ICD-10 Finland

Chronic mucoid otitis media

+∞

8.5

DCA20

NOMESCO Finland

Insertion of ventilating tube through tympanic membrane

+∞

8.5

H90.1

ICD-10 Finland

Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side

38.0

8.3

H66.9

ICD-10 Finland

Otitis media, unspecified

11.0

7.1

H66.0

ICD-10 Finland

Acute suppurative otitis media

8.4

6.6

H90.7

ICD-10 Finland

Mixed conductive and sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side

29.5

6.4

3812A

ICD-9 Finland

Nonsuppurative otitis media and Eustachian tube disorders, Chronic mucoid otitis media

+∞

6.3

4122

FHL

Tympanostomy (tympanic tube)

+∞

6.3

H72.2

ICD-10 Finland

Other marginal perforations of tympanic membrane

+∞

6.3

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

4.85

2.88

5.9

2.1

—

(3023419) Bacteria identified in Sputum by Culture

6.60

2.41

10.4

3.4

—

(3044290) Cell count panel - Cerebral spinal fluid

4.38

1.85

1.8

1.2

—

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

109

2.00

1.67

1.3

1.18

6.14

u/ml

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

188

1.79

1.52

2.9

3.1

1334.95

1337.73

ng/l

0.00

161

(3000494) Fungus identified in Specimen by Culture

1.95

1.20

1.2

1.4

—

(4024509) Urine culture

2.24

1.09

2.1

1.8

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.98

0.97

1.4

1.2

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.88

0.96

1.3

1.4

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.01

0.92

1.0

1.5

—

(3003694) ABO and Rh group [Type] in Blood

182

0.59

0.85

1.1

1.4

—

(3034770) Mitochondria Ab [Titer] in Serum

0.00

0.79

0.0

1.0

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

2.07

0.74

2.0

2.1

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

2.07

0.74

1.2

2.6

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

1.99

0.72

2.0

2.2

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

418

1.42

0.69

3.2

3.3

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

290

0.70

0.67

2.8

2.7

—

estimate

—

(3027008) Opiates [Presence] in Urine

1.83

0.60

1.3

2.4

—

(3027944) Amphetamines [Presence] in Urine

1.78

0.59

1.3

2.3

—

(3028300) Cannabinoids [Presence] in Urine

1.78

0.59

1.3

2.4

—

(3000764) Benzodiazepines [Presence] in Urine

1.78

0.59

1.3

2.3

—

(3008037) Lactate [Moles/volume] in Venous blood

0.00

0.59

0.0

3.1

—

1.50

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

285

1.36

0.58

2.1

2.2

98.79

92.22

pmol/l

0.46

151

(3014007) Fractional oxyhemoglobin in Arterial blood

1.58

0.54

13.2

10.7

91.52

93.96

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

632

1.63

0.53

6.4

5.7

2.79

2.71

mmol/l

0.35

585

(3022145) Colonoscopy Study observation

1.54

0.50

1.2

1.3

—

(3013512) EKG study

233

1.32

0.49

3.6

3.8

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

0.57

0.49

2.2

1.6

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

614

1.48

0.48

5.3

5.0

1.49

1.45

mmol/l

0.28

568

(3016879) Cocaine [Presence] in Urine

1.60

0.43

1.4

2.4

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

0.41

0.0

1.5

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.41

0.0

1.7

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

0.41

0.0

1.5

—

(40760892) CBC W Ordered Manual Differential panel - Blood

157

0.72

0.41

6.9

6.1

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

583

1.39

0.41

4.6

4.3

1.33

1.26

mmol/l

0.37

543

(3007778) Kappa light chains/Lambda light chains [Mass Ratio] in Serum

0.00

0.41

0.0

6.2

—

3.76

—

(46235831) Pregnancy associated plasma protein A [Multiple of the median] adjusted in Serum or Plasma

0.00

0.41

0.0

1.4

—

1.25

—

(3008714) Choriogonadotropin [Multiple of the median] adjusted in Serum or Plasma

0.00

0.41

0.0

1.4

—

1.24

—

(40763531) Fetal Nuchal fold [Multiple of the median] Thickness adjusted for maternal weight

0.00

0.41

0.0

1.4

—

1.07

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

0.00

0.40

0.0

2.3

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.40

0.0

2.2

—

(3020891) Body temperature

1.46

0.40

1.4

4.7

36.74

37.03

°c

—

(40768793) Breast Pathology biopsy report

0.00

0.39

0.0

1.2

—

(3016650) Hepatitis A virus Ab [Presence] in Serum

0.00

0.39

0.0

1.1

—

(3038515) Glucose [Moles/volume] in Venous blood

0.00

0.39

0.0

3.5

—

7.46

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

616

1.45

0.39

6.2

5.0

6.05

5.90

mmol/l

0.24

572

(3019060) Gas panel - Arterial blood

1.42

0.39

1.8

4.8

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

0.62

0.38

2.6

1.7

—

(4035726) Immunohistochemistry procedure

1.40

0.35

1.2

—

(3021589) Normoblasts [#/volume] in Blood

288

0.80

0.34

11.1

10.8

0.00

e9/l

-0.00

234

(3012516) Albumin [Mass/volume] in Urine

196

1.25

0.32

4.2

3.5

62.58

56.57

mg/l

0.06

134

(3048689) Calprotectin [Mass/mass] in Stool

1.35

0.32

1.5

2.2

179.57

160.60

ug/g

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

264

1.23

0.32

1.8

2.0

1.45

1.39

mmol/l

0.21

221

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

580

1.29

0.30

6.4

5.8

1.81

1.87

mu/l

0.16

532

(3006315) Basophils [#/volume] in Blood

325

1.21

0.29

6.4

5.9

0.04

e9/l

0.02

282

(3001604) Monocytes [#/volume] in Blood

325

1.21

0.29

6.4

5.9

0.55

0.54

e9/l

0.15

285

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

230

0.82

0.25

2.3

3.4

—

(40768797) Stomach Pathology biopsy report

0.73

0.25

1.7

1.2

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

0.75

0.24

1.1

1.5

—

(3022948) Iron [Moles/volume] in Serum or Plasma

110

0.79

0.22

4.4

2.8

10.74

14.19

umol/l

—

101

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

114

0.76

0.22

1.4

1.7

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.6

—

(3013290) Carbon dioxide [Partial pressure] in Blood

0.00

0.21

0.0

4.0

—

4.95

—

(3027315) Oxygen [Partial pressure] in Blood

0.00

0.21

0.0

4.0

—

8.78

—

(4195642) Thrombophilia screening test

0.00

0.21

0.0

1.5

—

(1616796) Gas panel - Central venous blood

0.00

0.21

0.0

2.5

—

(4268621) Lupus anticoagulant assay

0.00

0.21

0.0

2.2

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

0.00

0.21

0.0

1.4

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

0.00

0.21

0.0

1.3

—

(3012220) Varicella zoster virus IgM Ab [Presence] in Serum by Immunoassay

0.00

0.21

0.0

1.0

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

0.00

0.21

0.0

1.3

—

(3020682) Albumin/Creatinine [Ratio] in Urine

204

1.18

0.21

4.8

4.1

17.49

9.87

mg/mmol

0.28

130

(3025130) Human papilloma virus identified in Specimen

0.00

0.21

0.0

2.1

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.21

0.0

2.8

—

20.15

—

(40761536) Microorganisms panel - Urine sediment

1.24

0.20

4.7

4.2

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.20

0.0

1.9

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.20

0.0

3.2

—

3.99

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

0.00

0.20

0.0

1.9

—

6.18

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.20

0.0

3.2

—

1.19

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

0.00

0.20

0.0

1.1

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.20

0.0

3.2

—

105.86

—

(3037756) Immunofixation for Serum or Plasma

0.00

0.20

0.0

1.3

—

(3009041) Cardiolipin IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.20

0.0

1.4

—

5.75

—

(3015736) pH of Urine

284

1.16

0.19

3.2

3.6

6.28

6.19

0.18

162

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

629

0.83

0.17

15.4

15.1

18.54

21.93

mg/l

0.40

505

(40758558) Short blood count panel - Blood

189

1.16

0.16

3.1

7.1

—

(3003338) MCHC [Entitic Mass/volume] in Red Blood Cells

529

1.15

0.15

20.6

19.5

330.93

332.46

g/l

0.76

529

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

0.78

0.15

2.1

2.3

—

(40768804) Tissue Pathology biopsy report

240

1.13

0.14

2.5

2.0

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

123

1.17

0.13

1.9

1.6

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

147

0.86

0.13

1.5

1.9

—

(3023368) Bacteria identified in Blood by Culture

166

0.88

0.11

4.3

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

114

0.86

0.10

2.2

1.9

—

(4010399) Spirometry for bronchospasm with prolonged evaluation after bronchodilator

1.09

0.10

1.6

1.2

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.04

0.09

2.6

1.9

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

154

0.89

0.09

2.6

2.3

—

(3000492) Spirometry study

1.10

0.08

1.3

—

(3005719) IgG [Mass/volume] in Serum or Plasma

1.05

0.08

1.3

10.68

10.06

g/l

—

(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma

1.05

0.08

3.1

4.1

4.77

11.86

umol/l

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.03

0.08

6.9

7.6

—

(3019832) Treponema pallidum Ab [Presence] in Serum

0.79

0.08

1.5

1.8

—

(3002256) Pathology report gross observation

1.06

0.07

1.3

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

254

0.92

0.07

5.1

4.1

68.00

24.39

ng/l

0.45

188

(3044640) Blood type and Crossmatch panel - Blood

203

0.91

0.07

2.2

2.3

—

(3042936) Bacteria identified in Isolate by Culture

1.14

0.07

2.2

1.7

—

(3004789) Transferrin [Mass/volume] in Serum or Plasma

103

0.86

0.07

4.6

2.8

2.63

2.35

g/l

—

(40761511) CBC panel - Blood by Automated count

650

0.89

0.06

12.1

13.4

—

(3041096) Erythrocytes [Presence] in Urine by Automated

199

1.08

0.05

3.0

3.9

0.00

estimate

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

120

0.90

0.05

1.5

1.6

309.50

463.76

pmol/l

—

100

(3013650) Neutrophils [#/volume] in Blood by Automated count

369

1.06

0.04

8.0

9.8

4.25

4.11

e9/l

0.19

328

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

1.11

0.04

1.7

1.6

1.36

1.45

—

(3009261) Glucose [Presence] in Urine by Test strip

350

0.95

0.04

4.4

4.0

0.00

estimate

—

(1761868) Lipid panel - Serum or Plasma

241

1.06

0.03

2.7

3.3

—

(3035350) Ketones [Presence] in Urine by Test strip

348

0.96

0.02

4.1

3.9

0.00

estimate

—

(3018418) pH of Serum or Plasma

183

1.05

0.01

3.3

4.9

7.38

7.39

0.90

135

(3029937) Albumin [Presence] in Urine by Test strip

196

0.96

0.00

4.4

3.9

0.00

estimate

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

123

0.97

0.00

1.3

1.5

—

(3026008) Bacteria identified in Urine by Culture

201

0.99

0.00

3.6

3.2

—

(3018095) Leukocytes [#/volume] in Urine

242

0.99

0.00

2.6

3.8

81.18

44.71

e6/l

0.27

161

(3021601) Nitrite [Presence] in Urine by Test strip

344

0.98

0.00

4.0

3.9

0.00

estimate

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

0.91

0.00

10.5

7.5

104.75

103.99

mmol/l

—

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

0.94

0.00

1.6

3.0

23.40

29.95

u/l

—

(3019420) Tryptase [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

8.38

—

(3040363) Hepatitis A virus IgG Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.1

—

(3005757) Coagulation factor V activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

-0.00

0.0

3.7

—

91.50

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

-0.00

0.0

3.8

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

-0.00

0.0

3.3

—

90.93

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

-0.00

0.0

1.1

—

(40771527) Human papilloma virus E6+E7 mRNA [Presence] in Cervix by NAA with probe detection

0.00

-0.00

0.0

1.8

—

(3026725) Estradiol (E2) [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.4

—

0.30

—

(3043453) Neutrophil cytoplasmic Ab.perinuclear [Titer] in Serum

0.00

-0.00

0.0

1.0

—

(3015024) Glucose [Moles/volume] in Serum or Plasma --1 hour post dose glucose

0.00

-0.00

0.0

1.6

—

7.49

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.6

—

(40768441) Liver Pathology biopsy report

0.00

-0.00

0.0

1.7

—

(3045066) Thymidine kinase [Enzymatic activity/volume] in Serum

0.00

-0.00

0.0

1.2

—

39.27

—

(42529582) MDA5 Ab [Presence] in Serum by Line blot

0.00

-0.00

0.0

1.0

—

(42528593) TIF1-gamma Ab [Presence] in Serum by Line blot

0.00

-0.00

0.0

1.0

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

-0.00

0.0

1.0

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

0.00

-0.00

0.0

1.3

—

31.00

—

(3024172) Erythropoietin (EPO) [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

1.1

—

13.88

—

(3018301) Testosterone Free [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.3

—

214.67

—

(3013637) Mi-2 Ab [Presence] in Serum

0.00

-0.00

0.0

1.0

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

-0.00

0.0

1.0

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

-0.00

0.0

2.4

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

0.00

-0.00

0.0

2.4

—

(3026389) Candida sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3024666) Lithium [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

7.8

—

0.54

—

(42529598) SUMO-activating enzyme subunit 1 Ab [Presence] in Serum by Line blot

0.00

-0.00

0.0

1.0

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.01

-0.00

1.4

1.6

—

(3020717) Zinc [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

25.40

—

(3011648) Oxygen content in Venous blood

0.00

-0.00

0.0

2.1

—

10.77

—

(3023601) Vancomycin resistant enterococcus [Presence] in Specimen by Organism specific culture

0.00

-0.00

0.0

3.0

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.00

-0.00

2.7

2.5

—

(3029023) Hepatitis E virus IgG Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.0

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

1.5

—

303.10

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

-0.00

0.0

1.0

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.3

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.2

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.3

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

-0.00

0.0

5.4

—

216.14

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

-0.00

0.0

1.7

—

(4281824) Cell count and differential, peritoneal fluid

0.00

-0.00

0.0

1.0

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

270

1.00

-0.00

3.9

4.0

0.00

estimate

—

(3046896) Herpes virus 6 DNA [Presence] in Cerebral spinal fluid by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

-0.00

0.0

4.0

—

1.14

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

0.94

-0.00

2.4

1.8

467.71

392.56

nmol/l

—

(21494434) Karyotype in Bone marrow

0.00

-0.00

0.0

1.0

—

(21494890) Protein electrophoresis panel - 24 hour Urine

0.00

-0.00

0.0

6.4

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.3

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.3

—

(3027529) Toxoplasma gondii IgM Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.2

—

(3026515) Parvovirus B19 IgM Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.2

—

(3000208) Alpha tocopherol [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

33.80

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.3

—

(3002222) Hepatitis E virus IgM Ab [Presence] in Serum

0.00

-0.00

0.0

1.0

—

(3009466) Valproate [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

5.3

—

337.38

—

(40759850) Jo-1 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.3

—

(3006922) Hepatitis E virus Ab [Presence] in Serum

0.00

-0.00

0.0

1.0

—

(40757494) Bilirubin.total [Moles/volume] in Blood

0.00

-0.00

0.0

1.6

—

(3006571) Granulocytes/Leukocytes in Synovial fluid

0.00

-0.00

0.0

1.4

—

31.40

—

(3003245) Complement C1 esterase inhibitor [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

0.30

—

(3032700) Glomerular basement membrane Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.2

—

(3044927) Protein electrophoresis panel - Urine

0.00

-0.00

0.0

1.0

—

(37208534) Antinuclear antibody arbitrary concentration in serum

0.00

-0.00

0.0

1.0

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

-0.00

0.0

1.8

—

(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.8

—

(3018333) Ribosomal P Ab [Presence] in Serum

0.00

-0.00

0.0

1.3

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

-0.00

0.0

1.8

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.1

—

Mortality – FinRegistry

↥

Association

Association between endpoint H8_TYMPSCLE and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have H8_TYMPSCLE.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: H8_TYMPSCLE – Tympanosclerosis

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Tympanosclerosis

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints