auditory system disease: Pathological processes of the ear, the hearing, and the equilibrium system of the body.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
406 |
4. Check minimum number of eventsNone |
406 |
5. Include endpointsNone |
406 |
6. Filter based on genotype QC (FinnGen only) |
370 |
Control definitions (FinnGen only)
- Control exclude
- H8_EXTERNAL
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H61
- Name in latin
- Stenosis meatus acustici externi acquisita
Similar endpoints
↥List of similar endpoints to
Acquired stenosis of external ear canal
based on the number of shared cases.
Similar with more cases:
- Diseases of external ear
- Diseases of the ear and mastoid process
- Any operation in hilmo
- Any prescribed medicine buy
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1833 | 644 | 1188 |
| Only index persons | 1756 | 613 | 1143 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.02 | 0.03 |
| Only index persons | 0.04 | 0.02 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 57.68 | 56.60 | 58.25 |
| Only index persons | 57.63 | 56.73 | 58.11 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 370 | 111 | 259 |
| Unadjusted period prevalence (%) | 0.09 | 0.04 | 0.12 |
| Median age at first event (years) | 61.21 | 55.64 | 63.59 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 379
- Matched controls
- 3790
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H61.3
ICD-10 Finland
Acquired stenosis of external ear canal
4503599627370496.0
307.7
371
*
DBD20
NOMESCO Finland
Plastic repair of external auditory canal
1367.6
178.4
160
*
H61.8
ICD-10 Finland
Other specified disorders of external ear
241.9
93.0
92
5
UDC00
NOMESCO Finland
Ear microscopy
10.8
89.9
116
149
H60.9
ICD-10 Finland
Otitis externa, unspecified
10.9
78.3
96
114
H60.8
ICD-10 Finland
Other otitis externa
21.9
75.0
58
31
DFF00
NOMESCO Finland
Pure tone audiometry
7.9
72.2
124
220
Z01.1
ICD-10 Finland
Examination of ears and hearing
6.0
56.6
131
306
H60.3
ICD-10 Finland
Other infective otitis externa
19.3
53.1
43
25
H61.2
ICD-10 Finland
Impacted cerumen
7.7
44.1
68
104
DBB00
NOMESCO Finland
Excision of lesion of external auditory canal
+∞
39.3
37
*
H90.6
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, bilateral
15.3
38.7
35
25
H60
ICD-10 Finland
Otitis externa
7.7
37.1
56
83
DC1AD
NOMESCO Finland
Temporalbone CT
32.7
25.5
33
11
H71
ICD-10 Finland
Cholesteatoma of middle ear
34.8
25.1
32
10
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
3.4
24.7
120
459
S03CA04
ATC
hydrocortisone and antiinfectives; ophthalmic, otic
9.2
24.0
30
35
R5120
NOMESCO Finland
Preparation of an aid
6.6
17.5
29
47
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
3.2
16.6
79
292
TDW99
NOMESCO Finland
Other minor procedure in surgery of ear, nose and larynx
5.7
15.2
29
54
ZXE00
NOMESCO Finland
One hour or less
2.4
14.7
172
987
H72.0
ICD-10 Finland
Central perforation of tympanic membrane
12.0
14.5
26
23
H81
ICPC
Excessive ear wax
2.6
14.0
97
437
H90.1
ICD-10 Finland
Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side
12.7
13.8
24
20
H65.3
ICD-10 Finland
Chronic mucoid otitis media
11.1
12.9
24
23
ZXE10
NOMESCO Finland
More than one and less than three hours
2.2
12.3
158
927
WX402
NOMESCO Finland
General anaesthesia
2.4
11.9
109
554
H66.9
ICD-10 Finland
Otitis media, unspecified
4.2
11.8
33
85
DBD30
NOMESCO Finland
Correction of atresia of external auditory canal
+∞
11.5
11
*
Z3229
NOMESCO Finland
Other healthcare associate professional
3.2
11.2
47
160
H29
ICPC
Ear symptom/complaint other
2.7
11.0
65
268
TDA90
NOMESCO Finland
Removal wax from ear
12.4
11.0
19
16
R5130
NOMESCO Finland
Repair work or maintenance done on the aid
4.6
10.7
26
60
ZXD10
NOMESCO Finland
Scheduled procedure
2.0
10.0
155
961
H04
ICPC
Ear discharge
4.6
9.7
23
52
H13
ICPC
Plugged feeling ear
2.2
9.5
97
511
H66.3
ICD-10 Finland
Other chronic suppurative otitis media
30.9
9.5
12
*
H90.0
ICD-10 Finland
Conductive hearing loss, bilateral
12.8
9.4
16
13
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.3
9.4
88
447
Z97.4
ICD-10 Finland
Presence of external hearing-aid
3.5
9.3
33
101
H01
ICPC
Ear pain/earache
2.8
9.3
51
202
H92.0
ICD-10 Finland
Otalgia
3.7
9.1
30
87
DCD10
NOMESCO Finland
Tympanoplasty
37.7
9.1
11
*
DAX00
NOMESCO Finland
Adjustment or review of hearing aid
3.3
8.9
34
109
J01DB01
ATC
cefalexin; oral
2.5
8.8
325
2693
38700
ICD-8 Finland
Other disease of ear and mastoid process, Cholesteatoma of ear
51.2
8.7
10
*
WX408
NOMESCO Finland
General anesthesy, balanced
2.0
8.6
114
661
S02CA02
ATC
flumetasone and antiinfectives; otic
3.4
8.4
31
97
3805A
ICD-9 Finland
Disorders of external ear, Acquired stenosis of external ear canal
+∞
8.4
8
*
DBW99
NOMESCO Finland
Other operation on external auditory canal
+∞
8.4
8
*
Z46.1
ICD-10 Finland
Fitting and adjustment of hearing aid
3.0
8.2
38
137
H66.0
ICD-10 Finland
Acute suppurative otitis media
3.0
8.1
37
132
S03CA01
ATC
dexamethasone and antiinfectives; ophthalmic, otic
6.8
8.0
19
29
H65.0
ICD-10 Finland
Acute serous otitis media
8.7
7.9
16
19
H60.5
ICD-10 Finland
Acute otitis externa, noninfective
15.4
7.8
12
8
H60.4
ICD-10 Finland
Cholesteatoma of external ear
45.9
7.7
9
*
J01FA10
ATC
azithromycin; systemic
1.8
7.7
206
1490
ZXA00
NOMESCO Finland
Right side
2.0
7.6
113
677
J01DA08
ATC
[U] cefaclor
2.9
7.5
37
138
4111
FHL
Ear canal extension
81.6
7.4
8
*
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
8.6
7.4
15
18
H70
ICPC
Otitis externa
7.1
7.4
17
25
WX006
NOMESCO Finland
Intravenous sedation or analgesia without general anesthesia
2.9
7.3
36
134
DBD10
NOMESCO Finland
Reconstruction of external auditory canal
+∞
7.3
7
*
H66.4
ICD-10 Finland
Suppurative otitis media, unspecified
12.3
7.1
12
10
DFF15
NOMESCO Finland
Speech audiometry
3.1
7.0
29
98
H65.2
ICD-10 Finland
Chronic serous otitis media
7.8
7.0
15
20
ZXA10
NOMESCO Finland
Bilateral
2.1
6.9
78
423
R01AD08
ATC
fluticasone; nasal
1.9
6.7
107
653
D07AB02
ATC
hydrocortisone butyrate; topical
1.9
6.6
115
722
WX002
NOMESCO Finland
Sedation and analgesia
2.0
6.6
83
469
ZXD20
NOMESCO Finland
Day surgery
2.3
6.5
53
253
Q16.1
ICD-10 Finland
Congenital absence, atresia and stricture of auditory canal (external)
71.0
6.4
7
*
ZXA05
NOMESCO Finland
Left side
1.9
6.4
99
598
H95.1
ICD-10 Finland
Other disorders following mastoidectomy
+∞
6.3
6
*
M01AH05
ATC
etoricoxib; oral
1.8
6.3
247
1954
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
3.7
6.1
19
53
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
26
92
2.96
5.80
1.6
1.6
—
—
—
0
0
63
374
1.82
4.21
3.3
3.7
—
—
—
0
0
358
3320
2.41
3.96
5.9
6.1
2.66
2.64
mmol/l
0.13
335
3093
346
3180
2.01
3.70
20.2
16.7
79.68
80.10
ml/min/173m2
0.16
329
2974
74
478
1.68
3.68
2.7
2.4
14.77
13.67
nmol/l
0.44
63
436
235
1982
1.49
3.43
8.1
10.4
4.13
4.17
e9/l
0.09
201
1744
225
1884
1.48
3.38
2.5
2.8
—
—
—
0
0
370
3541
2.89
3.32
27.9
26.1
4.55
4.54
e12/l
0.02
362
3470
370
3539
2.92
3.31
27.9
26.1
241.54
240.95
e9/l
0.06
364
3482
277
2434
1.51
3.16
3.5
3.9
14.53
14.89
pmol/l
1.70
255
2211
53
814
0.59
3.11
3.2
4.0
1.02
1.02
kg/l
1.49
26
554
350
3264
1.94
3.05
5.1
5.3
1.40
1.39
mmol/l
0.10
326
3031
346
3217
1.87
3.01
5.5
5.3
5.97
6.05
mmol/l
0.59
317
2961
365
3460
2.49
2.99
13.5
12.9
26.24
27.93
u/l
1.56
355
3379
306
2762
1.56
2.94
22.4
21.2
13.72
13.69
%
0.11
301
2740
350
3277
1.89
2.81
5.4
5.4
4.56
4.50
mmol/l
0.52
328
3063
325
2988
1.62
2.73
5.0
4.9
1.98
1.96
mu/l
0.10
297
2749
181
1496
1.40
2.69
3.2
3.0
135.31
152.48
ug/l
0.57
165
1397
293
2639
1.49
2.66
8.6
9.0
79.28
80.72
u/l
0.24
271
2517
176
1451
1.40
2.64
2.0
2.1
1.50
1.38
mmol/l
0.72
139
1222
80
570
1.51
2.61
1.3
1.3
17.53
31.34
iu/ml
1.68
22
179
279
2497
1.44
2.55
4.1
4.4
11.35
11.69
mm/h
0.15
260
2343
346
3244
1.76
2.54
18.5
17.3
27.07
25.69
mg/l
0.31
292
2707
172
1433
1.37
2.34
2.5
2.5
73.38
75.40
nmol/l
0.42
152
1294
334
3125
1.58
2.20
4.4
4.5
1.39
1.32
mmol/l
0.81
311
2878
19
94
2.08
2.20
2.9
3.4
3.22
2.18
index
—
7
60
237
2089
1.36
2.18
4.7
5.5
6.64
6.77
mmol/l
0.53
226
1994
338
3185
1.57
1.99
6.6
6.8
39.23
39.82
mmol/mol
0.73
312
3007
12
51
2.40
1.97
1.2
1.5
—
—
—
0
0
8
27
3.00
1.94
1.1
1.1
—
—
—
0
0
355
3388
1.76
1.94
22.4
20.7
3.99
4.00
mmol/l
0.23
349
3332
87
667
1.40
1.92
3.1
3.2
2.46
2.45
mmol/l
0.29
81
602
49
340
1.51
1.82
6.1
8.0
1.34
1.32
mmol/l
0.03
49
334
47
326
1.50
1.76
3.0
2.7
33.68
177.92
u/l
0.49
41
279
108
875
1.33
1.67
2.3
2.3
2.50
2.90
mg/l
1.26
91
757
7
25
2.83
1.65
1.1
1.2
—
—
—
0
0
119
982
1.31
1.61
2.5
3.0
352.05
360.13
umol/l
0.44
103
873
19
107
1.82
1.57
1.5
1.6
—
—
—
0
0
135
1137
1.29
1.56
4.2
3.7
2.36
2.34
mmol/l
0.72
126
1037
7
28
2.53
1.46
1.7
2.0
13.19
13.24
%
—
7
28
5
16
3.15
1.44
1.4
1.8
—
—
—
0
0
5
16
3.15
1.44
1.4
1.8
—
—
—
0
0
5
16
3.15
1.44
1.4
1.8
—
—
—
0
0
5
16
3.15
1.44
5.0
6.0
—
—
—
0
0
5
16
3.15
1.44
1.4
1.8
—
—
—
0
0
184
1625
1.26
1.42
2.9
2.9
—
—
estimate
—
0
0
26
166
1.61
1.41
1.1
1.2
59.60
169.99
u/ml
—
5
60
14
76
1.87
1.31
1.4
1.3
—
—
—
0
0
134
1150
1.26
1.30
3.3
3.2
0.72
0.75
ug/l
0.13
83
738
251
2314
1.25
1.26
3.3
3.7
41.81
54.32
u/l
3.21
226
2198
66
519
1.33
1.25
1.4
1.3
19.05
12.41
u/ml
0.25
20
202
18
108
1.70
1.24
1.1
1.2
0.98
0.90
g/l
0.51
18
108
193
1732
1.23
1.23
7.1
7.9
1.21
1.21
mmol/l
0.49
159
1496
208
1882
1.23
1.23
6.1
5.5
1.89
2.17
ug/l
0.63
189
1706
133
1147
1.25
1.23
3.3
3.3
1265.04
1350.89
ng/l
0.10
115
991
88
723
1.28
1.22
1.2
1.3
4.72
1.31
u/ml
0.47
17
202
39
283
1.42
1.20
4.2
4.3
1.22
1.22
mmol/l
0.38
32
248
82
670
1.29
1.18
4.0
4.2
291.52
470.81
ng/l
0.45
71
560
175
1561
1.22
1.17
5.7
7.0
1.21
1.21
mmol/l
0.22
165
1440
63
498
1.32
1.16
6.9
6.7
0.98
1.04
mmol/l
0.86
56
463
100
845
1.25
1.10
2.5
2.5
—
—
—
0
0
11
59
1.89
1.08
3.8
2.2
32.73
33.81
pg
0.56
11
59
118
1020
1.23
1.05
3.3
3.2
0.18
0.47
e6/l
2.03
78
762
9
46
1.98
1.04
3.4
3.6
—
—
—
0
0
207
1897
1.20
1.00
6.6
7.6
12.13
12.25
umol/l
0.04
196
1819
172
1552
1.20
0.97
2.1
2.1
90.89
94.89
pmol/l
0.54
85
861
7
36
1.96
0.97
2.1
1.1
—
—
—
0
0
16
101
1.61
0.95
1.1
1.1
1.61
1.50
g/l
1.61
16
101
71
587
1.26
0.94
2.9
3.2
1.02
1.54
e6/l
0.43
28
315
18
119
1.54
0.90
2.1
1.8
—
—
—
0
0
142
1270
1.19
0.87
4.2
4.1
7.28
8.73
mg/mmol
0.21
87
835
168
1535
1.17
0.78
4.7
4.5
22.88
21.22
%
0.60
78
734
0
27
0.00
0.77
0.0
1.9
—
2.00
—
0
12
5
24
2.10
0.75
1.6
1.7
85.00
84.96
umol/l
—
5
24
123
1100
1.17
0.74
2.6
2.2
207.71
275.33
u/l
0.41
118
1045
29
376
0.75
0.74
5.5
8.3
—
—
—
0
0
74
633
1.21
0.73
2.9
3.0
0.58
0.96
e6/l
0.91
32
356
10
61
1.66
0.69
1.1
1.3
—
—
—
0
0
10
61
1.66
0.69
1.1
1.3
—
—
—
0
0
142
1292
1.16
0.68
3.3
3.4
9.03
8.34
mmol/l
0.89
111
1099
27
207
1.33
0.66
1.8
1.6
—
—
—
0
0
12
176
0.67
0.63
1.8
2.0
1.15
3.40
ug/l
0.70
12
155
11
71
1.57
0.62
2.6
3.3
6.83
8.54
pmol/l
0.38
11
71
8
49
1.65
0.62
1.1
1.4
—
—
—
0
0
33
264
1.27
0.60
1.3
1.4
—
—
—
0
0
283
2719
1.16
0.60
21.5
22.1
333.57
333.54
g/l
0.02
283
2709
0
21
0.00
0.60
0.0
2.9
—
1.48
—
0
21
63
543
1.19
0.59
3.1
2.6
22.56
23.30
%
0.22
58
509
133
1217
1.14
0.58
2.9
3.9
29.54
34.05
u/l
1.37
124
1153
0
23
0.00
0.58
0.0
1.4
—
—
—
0
0
71
624
1.17
0.54
3.1
2.7
12.77
13.09
umol/l
0.18
66
586
16
117
1.38
0.53
1.6
1.3
—
—
—
0
0
86
771
1.15
0.51
1.4
1.8
1.02
1.43
mg/l
1.28
67
615
131
1415
0.89
0.50
3.8
3.6
0.03
0.01
estimate
0.26
40
337
30
245
1.24
0.48
2.1
1.7
—
—
—
0
0
11
153
0.71
0.46
1.1
1.2
—
—
—
0
0
69
614
1.15
0.45
1.9
1.9
—
—
—
0
0
154
1442
1.11
0.45
3.6
4.1
21.60
38.65
ng/l
3.71
108
1101
64
719
0.87
0.45
1.7
1.9
419.28
43802086.35
pmol/l
0.97
53
605
29
239
1.23
0.44
4.2
4.6
108.51
92.33
ng/l
0.29
21
217
14
185
0.75
0.44
6.2
3.4
23.96
25.03
mmol/l
0.61
14
176
111
1023
1.12
0.43
1.7
1.8
20.53
20.05
nmol/l
0.14
94
874
28
231
1.23
0.42
3.1
3.1
2.34
1.78
mmol/l
0.32
21
177
0
16
0.00
0.41
0.0
1.3
—
0.60
—
0
10
0
17
0.00
0.40
0.0
1.0
—
—
—
0
0
0
17
0.00
0.40
0.0
1.1
—
—
—
0
0
33
279
1.20
0.40
1.5
1.4
—
—
—
0
0
0
18
0.00
0.40
0.0
1.0
—
—
—
0
0
36
418
0.85
0.39
5.1
5.0
32.14
31.37
%
0.16
29
280
11
80
1.39
0.39
1.5
1.5
—
—
—
0
0
19
152
1.26
0.37
2.3
2.0
379.18
614.71
ug/l
0.33
19
144
15
116
1.31
0.37
2.3
1.7
—
—
—
0
0
5
37
1.36
0.37
1.0
1.2
—
—
—
0
0
17
210
0.80
0.34
3.1
3.9
45.74
46.81
%
0.07
17
204
13
100
1.31
0.34
1.2
1.3
—
—
—
0
0
182
1741
1.09
0.33
14.8
15.3
1.27
1.26
inr
0.08
151
1460
48
428
1.14
0.32
2.5
3.3
14.13
9.23
umol/l
0.39
39
386
7
97
0.72
0.31
2.3
1.4
—
—
—
0
0
10
75
1.34
0.30
1.1
1.2
—
1.03
—
0
7
28
322
0.86
0.28
2.2
2.6
0.08
0.24
e6/l
2.21
28
309
11
85
1.30
0.28
1.2
1.3
—
2.71
—
0
14
56
612
0.90
0.27
2.1
2.2
30.88
29.47
s
1.02
56
599
40
445
0.89
0.26
1.9
1.8
1.45
1.60
%
0.96
35
381
25
216
1.17
0.26
2.4
2.6
22.86
14.75
au/ml
—
5
16
162
1555
1.07
0.26
6.0
5.7
35.19
35.45
g/l
0.23
149
1467
13
105
1.25
0.25
1.5
1.6
—
—
—
0
0
6
84
0.71
0.24
1.5
1.5
—
—
—
0
0
36
400
0.89
0.24
5.6
5.0
3.13
40.83
ug/l
1.16
31
334
17
143
1.20
0.23
1.6
1.8
3.08
3.03
g/l
0.06
17
132
28
316
0.88
0.23
2.0
2.7
66.21
66.45
g/l
0.07
28
297
5
38
1.32
0.23
1.4
1.6
—
—
—
0
0
5
38
1.32
0.23
1.4
1.6
—
—
—
0
0
5
38
1.32
0.23
1.4
1.6
—
—
—
0
0
5
38
1.32
0.23
1.0
1.1
—
—
—
0
0
10
79
1.27
0.22
1.4
1.5
30.20
119.63
e6/l
—
5
63
189
1831
1.06
0.22
3.6
3.7
0.00
4.09
estimate
0.50
48
397
187
1813
1.06
0.21
3.7
3.7
0.00
0.00
estimate
-0.00
48
391
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
97
1019
0.94
0.20
4.2
3.8
0.00
0.02
estimate
0.96
47
353
0
14
0.00
0.20
0.0
1.2
—
40.66
—
0
14
22
193
1.15
0.20
1.4
1.4
78.13
57.84
au/ml
—
6
17
6
51
1.18
0.19
1.0
1.2
—
—
—
0
0
17
147
1.16
0.18
1.0
1.0
—
—
—
0
0
17
147
1.16
0.18
4.0
2.5
24.02
24.76
mmol/l
0.43
17
147
59
554
1.08
0.17
1.9
1.7
1184.26
1191.35
nmol/l
0.02
45
422
52
487
1.08
0.16
1.5
1.5
—
—
—
0
0
62
585
1.07
0.16
3.4
2.6
2.36
2.25
g/l
0.71
56
541
8
71
1.13
0.16
1.8
1.8
—
—
—
0
0
36
333
1.09
0.15
2.3
3.2
4.25
4.47
kpa
0.30
36
322
38
354
1.08
0.14
2.7
2.5
0.22
0.21
g/l
0.40
38
326
8
98
0.81
0.14
1.4
1.5
—
—
—
0
0
17
151
1.13
0.13
1.6
1.8
4.02
4.23
g/l
0.62
17
140
17
151
1.13
0.13
1.6
1.8
7.31
7.30
g/l
0.00
17
140
17
151
1.13
0.13
2.8
3.0
—
—
—
0
0
5
46
1.09
0.09
1.8
1.8
—
—
—
0
0
49
468
1.05
0.09
1.8
1.8
—
—
—
0
0
5
47
1.06
0.09
1.0
1.4
—
—
—
0
0
24
223
1.08
0.09
1.6
1.8
—
—
—
0
0
27
287
0.94
0.08
2.2
2.6
59.87
65.33
ml/min/173m2
0.41
15
130
10
88
1.14
0.08
1.0
1.2
—
—
—
0
0
41
392
1.05
0.08
3.6
3.9
5.96
5.82
kpa
0.54
41
379
8
78
1.03
0.07
1.3
1.2
—
—
—
0
0
9
88
1.02
0.07
1.3
1.5
—
—
—
0
0
9
103
0.87
0.06
1.1
1.3
—
—
—
0
0
16
172
0.93
0.06
1.4
1.6
0.20
0.35
mg/l
1.17
11
82
102
1039
0.97
0.05
3.6
3.1
0.00
0.08
estimate
0.52
39
316
11
120
0.91
0.05
5.5
3.0
1.08
2.80
ratio
—
6
62
10
109
0.92
0.04
1.6
1.7
—
—
—
0
0
45
440
1.03
0.02
1.9
1.9
—
—
—
0
0
186
1850
1.01
0.02
3.7
3.7
0.00
0.83
estimate
0.51
45
365
24
247
0.97
0.01
1.6
2.0
—
—
—
0
0
34
347
0.98
0.01
1.7
2.1
3.83
3.63
ratio
0.42
26
283
117
1163
1.01
0.01
2.9
2.9
53.21
66.28
u/l
1.46
101
1090
10
102
0.98
0.00
1.4
1.6
—
—
—
0
0
20
199
1.01
0.00
1.3
1.4
—
—
—
0
0
11
107
1.03
0.00
1.1
1.5
—
—
—
0
0
11
107
1.03
0.00
3.1
2.0
—
—
—
0
0
11
105
1.05
0.00
1.3
1.2
—
—
—
0
0
24
245
0.98
0.00
1.5
1.8
3.61
3.50
mmol/l
0.14
18
185
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
0.34
—
0
8
9
94
0.96
-0.00
1.2
1.3
—
—
—
0
0
9
95
0.95
-0.00
2.9
1.9
—
—
—
0
0
0
8
0.00
-0.00
0.0
8.5
—
11.01
—
0
8
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
9
92
0.98
-0.00
1.1
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
6.28
—
0
5
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
5
53
0.94
-0.00
1.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
6.4
—
5.38
—
0
5
7
76
0.92
-0.00
1.3
1.4
—
—
—
0
0
7
78
0.90
-0.00
1.4
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
3.6
—
40.57
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.9
—
1.27
—
0
8
9
91
0.99
-0.00
1.1
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.6
—
57.14
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H8_STENOEXTCAN and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_STENOEXTCAN | 1.036 [0.77, 1.39] | 0.814 |
| Birth year | 0.994 [0.99, 1.0] | 0.2 |
During the follow-up period (1.1.1998 — 31.12.2019), 58 out of 489 females with H8_STENOEXTCAN died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_STENOEXTCAN | 1.014 [0.79, 1.31] | 0.914 |
| Birth year | 0.982 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 96 out of 868 males with H8_STENOEXTCAN died.
Mortality risk
Mortality risk for people of age
years, who have H8_STENOEXTCAN.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.09% | 0.156% |
| 5 | 0.533% | 1.027% |
| 10 | 1.478% | 2.479% |
| 15 | 2.824% | 4.708% |
| 20 | 4.799% | 7.887% |
Relationships between endpoints
↥Index endpoint: H8_STENOEXTCAN – Acquired stenosis of external ear canal
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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