eye disease: A non-neoplastic or neoplastic disorder that affects the eye. Representative examples include conjunctivitis, glaucoma, cataract, conjunctival squamous cell carcinoma, uveal melanoma, and retinoblastoma. [NCIt:C26767]
Other/unspecified postprocedural disorders of ear and mastoid process
DOID EFO Endpoint Browser PheWeb
H8_POSTOPNAS
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
112 |
4. Check minimum number of eventsNone |
112 |
5. Include endpointsNone |
112 |
6. Filter based on genotype QC (FinnGen only) |
96 |
Control definitions (FinnGen only)
- Control exclude
- H8_OTHEREAR
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other/unspecified postprocedural disorders of ear and mastoid process
based on the number of shared cases.
Similar with more cases:
- Postprocedural disorders of ear and mastoid process, not elsewhere classified
- Other disorders of ear
- Diseases of the ear and mastoid process
- Any operation in hilmo
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 977 | 479 | 495 |
| Only index persons | 935 | 464 | 471 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 64.74 | 67.98 | 61.54 |
| Only index persons | 64.84 | 67.85 | 61.88 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 96 | 45 | 51 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | 66.64 | 63.92 | 69.04 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 105
- Matched controls
- 1050
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
UDC00
NOMESCO Finland
Ear microscopy
80.3
114.4
73
29
H95.8
ICD-10 Finland
Other postprocedural disorders of ear and mastoid process
+∞
107.6
84
*
DFF00
NOMESCO Finland
Pure tone audiometry
26.3
50.6
40
24
H71
ICD-10 Finland
Cholesteatoma of middle ear
154.6
45.1
45
5
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
79.1
36.7
40
8
H95.1
ICD-10 Finland
Other disorders following mastoidectomy
+∞
33.1
30
*
Z01.1
ICD-10 Finland
Examination of ears and hearing
13.0
30.4
35
39
H95.9
ICD-10 Finland
Postprocedural disorder of ear and mastoid process, unspecified
+∞
27.3
25
*
H90.6
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, bilateral
+∞
27.3
25
*
WX704
NOMESCO Finland
Intubation
11.6
25.0
30
35
H72.0
ICD-10 Finland
Central perforation of tympanic membrane
102.3
22.8
24
*
H95.0
ICD-10 Finland
Recurrent cholesteatoma of postmastoidectomy cavity
+∞
19.4
18
*
DAX00
NOMESCO Finland
Adjustment or review of hearing aid
114.8
18.2
19
*
H66.3
ICD-10 Finland
Other chronic suppurative otitis media
200.6
17.0
17
*
WX720
NOMESCO Finland
Own respiration
15.5
16.8
28
24
H66.4
ICD-10 Finland
Suppurative otitis media, unspecified
57.3
16.7
19
*
H66.9
ICD-10 Finland
Otitis media, unspecified
14.8
16.5
28
25
DBD20
NOMESCO Finland
Plastic repair of external auditory canal
100.5
16.1
17
*
DFF15
NOMESCO Finland
Speech audiometry
35.7
14.4
18
6
DAX08
NOMESCO Finland
Fitting of hearing aid
40.0
14.0
17
5
TDA90
NOMESCO Finland
Removal wax from ear
159.8
13.8
14
*
DFF30
NOMESCO Finland
Loudness discomfort Level (LDL)
+∞
12.8
12
*
H90.7
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
+∞
12.8
12
*
38700
ICD-8 Finland
Other disease of ear and mastoid process, Cholesteatoma of ear
146.8
12.7
13
*
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
6.0
12.4
26
55
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
5.5
12.1
28
65
H66.0
ICD-10 Finland
Acute suppurative otitis media
10.0
11.9
24
30
3853A
ICD-9 Finland
Other disorders of middle ear and mastoid, Cholesteatoma of middle ear and mastoid
73.4
11.9
13
*
Z97.8
ICD-10 Finland
Presence of other specified devices
73.4
11.9
13
*
Z01.8
ICD-10 Finland
Other specified special examinations
4.4
11.7
40
128
DCD00
NOMESCO Finland
Myringoplasty
134.1
11.7
12
*
38210
ICD-8 Finland
Chronic otitis media with mastoiditis
134.1
11.7
12
*
DEB25
NOMESCO Finland
Attico-antro-mastoidectomy and tympanoplasty
134.1
11.7
12
*
38110
ICD-8 Finland
Otitis media without mention of mastoiditis, Chronic
67.0
10.9
12
*
DEA10
NOMESCO Finland
Attico-antrotomy
+∞
10.6
10
*
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
44.6
10.2
12
*
WX725
NOMESCO Finland
Noninvasive ventilation
8.7
10.2
22
31
H65.3
ICD-10 Finland
Chronic mucoid otitis media
29.3
10.1
13
5
H60.9
ICD-10 Finland
Otitis externa, unspecified
8.8
9.8
21
29
H90.1
ICD-10 Finland
Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side
109.5
9.6
10
*
H73.1
ICD-10 Finland
Chronic myringitis
+∞
9.5
9
*
S03CA01
ATC
dexamethasone and antiinfectives; ophthalmic, otic
17.7
9.3
14
9
N03AX12
ATC
[U] gabapentin; oral
4.0
9.0
32
103
SPAT1301
SPAT
No procedures
3.5
9.0
49
210
TPH04
NOMESCO Finland
Cathetrisation of vein
3.6
9.0
41
157
WX702
NOMESCO Finland
Supraglottic ventilation device
7.7
8.7
20
31
H90.4
ICD-10 Finland
Sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
97.6
8.5
9
*
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
7.0
8.2
20
34
4147
FHL
Radical surgery, cavity filling and middle ear and / or eardrum plastic
48.8
7.8
9
*
H65.4
ICD-10 Finland
Other chronic nonsuppurative otitis media
48.8
7.8
9
*
DCD10
NOMESCO Finland
Tympanoplasty
85.9
7.5
8
*
H74.2
ICD-10 Finland
Discontinuity and dislocation of ear ossicles
85.9
7.5
8
*
3821A
ICD-9 Finland
Suppurative and unspecified otitis media, Chronic tubotympanic suppurative otitis media
85.9
7.5
8
*
H65.2
ICD-10 Finland
Chronic serous otitis media
21.9
7.3
10
5
H72.2
ICD-10 Finland
Other marginal perforations of tympanic membrane
32.5
7.3
9
*
S02CA02
ATC
flumetasone and antiinfectives; otic
6.6
7.2
18
32
SPAT1097
SPAT
Recording of ECG
3.6
7.1
28
96
I20.01
ICD-10 Finland
Unstable angina
15.2
7.1
11
8
J01DA09
ATC
[U] cefadroxil
3.1
6.6
38
164
XQ855, ,
SPAT
74.2
6.5
7
*
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
4.3
6.4
18
48
DEB20
NOMESCO Finland
Attico-antro-mastoidectomy and tympanotomy
+∞
6.3
6
*
TDW99
NOMESCO Finland
Other minor procedure in surgery of ear, nose and larynx
11.0
6.2
11
11
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
3.8
6.1
21
65
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
3.2
6.0
30
118
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
54
205
4.36
12.71
5.2
4.5
1.02
1.02
kg/l
0.13
40
148
46
202
3.27
7.98
5.6
3.7
28.07
267.82
ng/l
2.18
41
173
35
134
3.42
7.52
2.1
1.9
—
—
—
0
0
35
137
3.33
7.23
2.2
1.8
—
—
—
0
0
64
847
0.37
5.36
16.4
18.5
72.33
76.00
ml/min/173m2
0.61
57
789
31
138
2.77
4.93
8.5
8.3
2.48
0.48
mmol/l
2.51
26
116
11
18
6.69
4.74
2.5
1.4
—
—
—
0
0
7
5
14.85
4.64
1.3
1.2
—
—
—
0
0
36
184
2.46
4.27
2.3
2.0
—
—
—
0
0
0
92
0.00
3.71
0.0
3.7
—
1.22
—
0
83
7
15
4.92
2.64
1.0
1.2
—
—
—
0
0
11
38
3.11
2.50
3.1
2.1
—
—
—
0
0
8
24
3.52
2.23
1.0
1.3
—
—
—
0
0
11
227
0.42
1.99
4.3
2.4
—
—
—
0
0
51
378
1.68
1.83
5.1
4.1
—
0.00
estimate
—
0
96
19
105
1.99
1.77
1.1
1.4
—
—
—
0
0
5
13
3.98
1.73
1.0
1.2
—
—
—
0
0
5
13
3.98
1.73
4.2
2.5
13.60
9.46
mmol/l
—
5
13
7
28
2.60
1.48
1.0
1.3
—
—
—
0
0
64
524
1.57
1.40
7.5
7.0
9.58
12.03
umol/l
1.93
64
505
0
33
0.00
1.18
0.0
5.1
—
25.04
—
0
33
0
30
0.00
0.99
0.0
1.4
—
—
—
0
0
43
342
1.44
0.99
2.7
4.1
16.33
11.72
mg/mmol
0.15
26
222
14
86
1.72
0.96
4.0
3.7
79.45
86.69
ng/l
0.17
14
75
6
27
2.29
0.95
1.0
1.3
—
—
—
0
0
29
374
0.69
0.90
4.0
3.5
—
—
—
0
0
13
82
1.67
0.82
2.7
1.5
—
—
—
0
0
0
27
0.00
0.78
0.0
1.6
—
—
—
0
0
0
27
0.00
0.78
0.0
1.6
—
—
—
0
0
5
24
2.14
0.75
1.4
1.3
764.20
376.68
e6/l
—
5
19
5
24
2.14
0.75
1.4
1.1
0.80
4.26
e6/l
—
5
19
59
512
1.35
0.75
5.1
4.2
—
14.50
estimate
—
0
112
25
193
1.39
0.66
2.0
3.2
0.84
0.81
mmol/l
0.85
25
182
8
49
1.68
0.64
2.0
2.7
4.25
4.34
pmol/l
—
8
41
30
365
0.75
0.61
4.4
3.5
2432.23
1409.22
ng/l
0.45
30
319
54
473
1.29
0.60
3.2
2.7
—
—
—
0
0
6
40
1.53
0.52
1.5
1.2
—
—
—
0
0
50
441
1.26
0.50
2.3
2.3
98.75
94.52
pmol/l
0.35
25
236
5
32
1.59
0.43
1.0
1.9
—
—
—
0
0
0
15
0.00
0.41
0.0
3.9
—
24.25
—
0
8
0
16
0.00
0.41
0.0
1.4
—
—
—
0
0
47
421
1.21
0.39
4.0
2.7
—
—
estimate
—
0
0
32
278
1.22
0.35
2.5
3.6
—
0.00
estimate
—
0
89
16
128
1.29
0.34
4.4
4.6
247.62
236.10
u/l
0.12
16
122
47
426
1.19
0.33
2.9
2.5
81.11
76.91
nmol/l
0.56
47
374
21
176
1.24
0.32
4.1
2.4
2.19
2.25
g/l
0.20
21
161
55
508
1.17
0.30
5.2
4.1
—
0.00
estimate
—
0
109
24
277
0.83
0.30
3.1
2.3
2.55
2.78
mg/l
0.18
24
245
93
902
1.27
0.26
32.3
21.8
3.94
3.99
mmol/l
1.12
93
875
75
715
1.17
0.26
9.7
8.6
85.25
82.35
u/l
0.22
75
681
39
426
0.87
0.25
4.1
3.1
140.44
134.45
ug/l
0.05
39
393
10
124
0.79
0.23
4.3
3.7
5.53
5.78
kpa
—
10
118
11
89
1.26
0.22
1.9
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
6
50
1.21
0.20
1.0
1.0
—
—
—
0
0
93
907
1.22
0.20
14.7
12.9
25.66
24.62
u/l
0.32
93
878
88
855
1.18
0.19
6.0
5.4
5.99
6.08
mmol/l
0.24
88
771
7
62
1.14
0.17
5.7
2.6
1.43
1.01
%
—
7
62
28
255
1.13
0.17
2.6
2.7
358.29
355.94
umol/l
0.04
28
214
22
197
1.15
0.17
1.8
1.7
1079.23
1150.51
nmol/l
0.24
22
161
8
99
0.79
0.14
34.5
8.9
—
—
—
0
0
92
902
1.16
0.13
32.4
21.6
139.91
139.64
mmol/l
0.38
92
877
16
143
1.14
0.12
7.5
4.5
1.06
1.07
mmol/l
0.06
16
132
89
873
1.13
0.11
25.8
18.2
21.45
25.64
mg/l
0.78
78
722
15
164
0.90
0.08
9.1
8.2
103.93
104.38
mmol/l
0.12
15
164
23
215
1.09
0.08
1.8
1.8
1.65
1.61
mg/l
0.01
17
174
94
927
1.13
0.08
37.3
27.3
91.14
91.49
fl
0.29
94
915
94
927
1.13
0.08
38.0
28.0
39.54
39.81
%
0.25
94
915
93
917
1.12
0.08
32.9
24.2
87.92
80.91
umol/l
0.47
93
902
94
928
1.12
0.07
37.7
27.5
131.73
133.09
g/l
0.38
94
915
32
312
1.04
0.02
1.6
1.8
20.37
20.89
nmol/l
0.06
32
261
39
398
0.97
0.02
4.0
4.1
29.82
43.20
ng/l
0.77
29
307
16
164
0.97
0.00
2.0
1.3
19.50
39.69
iu/ml
—
10
59
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
32.31
—
0
5
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
1.18
—
0
6
0
9
0.00
-0.00
0.0
2.2
—
—
—
0
0
30
300
1.00
-0.00
6.1
5.2
24.24
21.78
%
0.32
15
151
0
7
0.00
-0.00
0.0
1.7
—
46.97
—
0
7
0
6
0.00
-0.00
0.0
1.5
—
0.88
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
0
7
0.00
-0.00
0.0
3.3
—
129.43
—
0
7
0
7
0.00
-0.00
0.0
1.6
—
60.37
—
0
7
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
1.06
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.2
—
—
—
0
0
7
71
0.98
-0.00
1.7
2.1
9.43
12.80
nmol/l
—
7
62
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H8_POSTOPNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_POSTOPNAS | 1.092 [0.84, 1.41] | 0.506 |
| Birth year | 0.991 [0.98, 1.0] | 0.038 |
During the follow-up period (1.1.1998 — 31.12.2019), 86 out of 440 females with H8_POSTOPNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_POSTOPNAS | 1.324 [0.98, 1.79] | 0.067 |
| Birth year | 0.984 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 96 out of 441 males with H8_POSTOPNAS died.
Mortality risk
Mortality risk for people of age
years, who have H8_POSTOPNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.087% | 0.227% |
| 5 | 0.539% | 1.316% |
| 10 | 1.37% | 3.49% |
| 15 | 2.665% | 6.444% |
| 20 | 4.665% | 10.797% |
Relationships between endpoints
↥Index endpoint: H8_POSTOPNAS – Other/unspecified postprocedural disorders of ear and mastoid process
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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