eye disease: A non-neoplastic or neoplastic disorder that affects the eye. Representative examples include conjunctivitis, glaucoma, cataract, conjunctival squamous cell carcinoma, uveal melanoma, and retinoblastoma. [NCIt:C26767]
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
158 |
4. Check minimum number of eventsNone |
158 |
5. Include endpointsNone |
158 |
6. Filter based on genotype QC (FinnGen only) |
131 |
Control definitions (FinnGen only)
- Control exclude
- H8_OTHEREAR
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H95
- Name in latin
- Aliae morbositates post operationem auris mediae
Similar endpoints
↥List of similar endpoints to
Other disorders following mastoidectomy
based on the number of shared cases.
Similar with more cases:
- Postprocedural disorders of ear and mastoid process, not elsewhere classified
- Other disorders of ear
- Diseases of the ear and mastoid process
- Any operation in hilmo
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1322 | 658 | 658 |
| Only index persons | 1256 | 626 | 630 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 65.04 | 68.12 | 61.92 |
| Only index persons | 64.61 | 67.69 | 61.56 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 131 | 62 | 69 |
| Unadjusted period prevalence (%) | 0.03 | 0.02 | 0.03 |
| Median age at first event (years) | 62.40 | 61.37 | 63.33 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 141
- Matched controls
- 1410
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H95.1
ICD-10 Finland
Other disorders following mastoidectomy
+∞
203.7
141
*
UDC00
NOMESCO Finland
Ear microscopy
144.2
186.8
106
29
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
78.9
97.0
54
11
DFF00
NOMESCO Finland
Pure tone audiometry
38.7
89.5
62
28
H71
ICD-10 Finland
Cholesteatoma of middle ear
1600.6
87.4
76
*
H90.6
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, bilateral
+∞
42.9
39
*
Z01.1
ICD-10 Finland
Examination of ears and hearing
11.8
38.9
48
59
DAX08
NOMESCO Finland
Fitting of hearing aid
63.3
30.0
34
7
38700
ICD-8 Finland
Other disease of ear and mastoid process, Cholesteatoma of ear
+∞
28.1
26
*
DAX00
NOMESCO Finland
Adjustment or review of hearing aid
115.5
26.7
28
*
H95.8
ICD-10 Finland
Other postprocedural disorders of ear and mastoid process
+∞
25.8
24
*
H66.3
ICD-10 Finland
Other chronic suppurative otitis media
+∞
25.8
24
*
WX704
NOMESCO Finland
Intubation
8.9
22.7
32
45
Z46.1
ICD-10 Finland
Fitting and adjustment of hearing aid
22.6
22.2
32
18
H95.0
ICD-10 Finland
Recurrent cholesteatoma of postmastoidectomy cavity
+∞
21.4
20
*
DFF15
NOMESCO Finland
Speech audiometry
32.9
21.0
27
10
WX725
NOMESCO Finland
Noninvasive ventilation
9.7
20.3
26
32
H66.9
ICD-10 Finland
Otitis media, unspecified
9.9
19.9
25
30
H72.0
ICD-10 Finland
Central perforation of tympanic membrane
54.5
19.9
23
5
H66.0
ICD-10 Finland
Acute suppurative otitis media
8.1
18.1
27
40
38210
ICD-8 Finland
Chronic otitis media with mastoiditis
+∞
18.1
17
*
3853A
ICD-9 Finland
Other disorders of middle ear and mastoid, Cholesteatoma of middle ear and mastoid
+∞
18.1
17
*
H90.7
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
+∞
18.1
17
*
Z97.4
ICD-10 Finland
Presence of external hearing-aid
33.9
18.1
23
8
S02CA02
ATC
flumetasone and antiinfectives; otic
7.9
17.7
27
41
H90.1
ICD-10 Finland
Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side
+∞
17.0
16
*
DFF30
NOMESCO Finland
Loudness discomfort Level (LDL)
191.7
16.9
17
*
Z01.8
ICD-10 Finland
Other specified special examinations
4.7
16.9
55
170
38110
ICD-8 Finland
Otitis media without mention of mastoiditis, Chronic
54.4
16.5
19
*
DEB25
NOMESCO Finland
Attico-antro-mastoidectomy and tympanoplasty
+∞
15.9
15
*
H66.4
ICD-10 Finland
Suppurative otitis media, unspecified
63.9
15.1
17
*
H65.3
ICD-10 Finland
Chronic mucoid otitis media
22.1
14.8
21
11
TDA90
NOMESCO Finland
Removal wax from ear
47.9
14.5
17
*
H90.4
ICD-10 Finland
Sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
83.1
13.9
15
*
H60.9
ICD-10 Finland
Otitis externa, unspecified
11.1
13.7
26
28
WX720
NOMESCO Finland
Own respiration
11.9
13.7
25
25
DBD20
NOMESCO Finland
Plastic repair of external auditory canal
77.0
12.8
14
*
H74.1
ICD-10 Finland
Adhesive middle ear disease
+∞
12.7
12
*
DCD00
NOMESCO Finland
Myringoplasty
+∞
12.7
12
*
S03CA01
ATC
dexamethasone and antiinfectives; ophthalmic, otic
15.5
11.9
19
14
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
4.7
11.8
31
79
H70.1
ICD-10 Finland
Chronic mastoiditis
+∞
11.6
11
*
Z97.8
ICD-10 Finland
Presence of other specified devices
130.2
11.6
12
*
Z98.8
ICD-10 Finland
Other specified postsurgical states
22.3
11.4
16
8
H93.1
ICD-10 Finland
Tinnitus
27.7
11.4
15
6
DEA10
NOMESCO Finland
Attico-antrotomy
+∞
10.5
10
*
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
4.5
9.8
27
71
-31
ICPC
Medical examin/health eval partial
5.1
9.7
22
49
H65.4
ICD-10 Finland
Other chronic nonsuppurative otitis media
32.5
9.6
12
*
4151
FHL
Reoperation for chronic otitis media
+∞
9.5
9
*
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
5.2
9.4
21
46
H90.0
ICD-10 Finland
Conductive hearing loss, bilateral
39.4
9.2
11
*
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
11.9
9.1
16
15
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
3.4
8.7
38
138
H90.8
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, unspecified
95.5
8.5
9
*
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
2.9
8.3
54
247
H65.2
ICD-10 Finland
Chronic serous otitis media
19.7
7.7
11
6
TDW99
NOMESCO Finland
Other minor procedure in surgery of ear, nose and larynx
11.0
7.7
14
14
R5130
NOMESCO Finland
Repair work or maintenance done on the aid
26.7
7.7
10
*
J01DA09
ATC
[U] cefadroxil
2.8
7.6
50
228
4147
FHL
Radical surgery, cavity filling and middle ear and / or eardrum plastic
+∞
7.3
7
*
H74.2
ICD-10 Finland
Discontinuity and dislocation of ear ossicles
+∞
7.3
7
*
DC1AD
NOMESCO Finland
Temporalbone CT
31.8
7.2
9
*
DCA10
NOMESCO Finland
Paracentesis of tympanic membrane
23.8
6.8
9
*
K01
ICPC
Heart pain
73.0
6.5
7
*
H72.1
ICD-10 Finland
Attic perforation of tympanic membrane
73.0
6.5
7
*
3821A
ICD-9 Finland
Suppurative and unspecified otitis media, Chronic tubotympanic suppurative otitis media
73.0
6.5
7
*
XQ855, ,
SPAT
28.1
6.3
8
*
ICB01, ,
SPAT
+∞
6.3
6
*
H95.9
ICD-10 Finland
Postprocedural disorder of ear and mastoid process, unspecified
+∞
6.3
6
*
TPH07
NOMESCO Finland
Cathetrisation of artery
3.2
6.2
28
102
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
41
171
2.97
7.32
3.0
1.8
—
—
—
0
0
38
170
2.69
5.84
2.8
1.8
—
—
—
0
0
45
228
2.43
5.30
3.0
1.9
—
—
—
0
0
24
492
0.38
4.58
4.0
3.5
—
—
—
0
0
64
441
1.83
3.04
4.0
4.1
3.34
15.09
mg/mmol
2.91
31
292
93
722
1.85
2.95
3.0
3.2
46.22
49.96
u/l
0.17
83
678
28
148
2.11
2.87
5.4
5.0
29.59
33.69
%
1.64
17
84
45
284
1.86
2.79
4.8
4.5
1.02
1.02
kg/l
0.75
39
205
11
36
3.23
2.63
1.3
1.3
—
—
—
0
0
62
442
1.72
2.51
2.5
2.0
1.47
1.32
mmol/l
0.84
54
365
8
23
3.62
2.31
5.1
2.3
11.25
9.47
mmol/l
—
8
23
30
182
1.82
2.07
6.3
7.0
3.97
0.80
mmol/l
3.29
21
149
77
604
1.61
2.03
6.0
6.3
1.21
1.21
mmol/l
0.00
72
563
74
577
1.59
1.98
2.3
2.3
90.92
92.70
pmol/l
0.13
41
298
120
1061
1.88
1.92
5.2
5.3
2.20
1.99
mu/l
0.78
109
951
5
135
0.35
1.88
1.8
2.4
36.80
30.32
u/l
—
5
113
14
261
0.49
1.82
2.6
3.2
0.59
0.72
ug/l
—
9
174
8
30
2.76
1.75
2.4
2.4
—
—
—
0
0
5
14
3.66
1.63
1.0
1.1
—
—
—
0
0
11
50
2.30
1.61
4.1
2.3
—
—
—
0
0
5
15
3.41
1.53
1.2
1.0
—
—
—
0
0
98
1098
0.65
1.50
13.4
18.9
73.21
75.68
ml/min/173m2
0.53
87
1022
18
291
0.56
1.47
1.8
2.4
—
—
—
0
0
20
120
1.78
1.43
3.0
3.8
81.35
92.16
ng/l
0.33
20
106
121
1100
1.71
1.39
6.2
5.4
5.86
6.09
mmol/l
1.64
111
989
74
609
1.45
1.37
3.3
2.7
—
—
—
0
0
8
158
0.48
1.35
2.1
4.4
5.63
5.74
kpa
—
8
152
100
876
1.49
1.31
3.8
4.2
14.95
14.96
pmol/l
0.02
90
777
18
108
1.76
1.30
2.1
1.6
—
—
—
0
0
67
547
1.43
1.27
2.3
2.5
80.87
77.13
nmol/l
0.58
61
474
79
674
1.39
1.12
5.2
6.5
10.08
12.21
umol/l
2.07
74
647
8
149
0.51
1.11
2.1
3.7
—
—
—
0
0
13
213
0.57
1.11
4.8
7.2
104.77
104.31
mmol/l
0.17
13
213
78
667
1.38
1.08
9.9
6.9
1.22
1.21
mmol/l
0.81
73
577
7
34
2.11
1.04
1.3
1.6
—
0.09
—
0
8
0
28
0.00
0.99
0.0
1.4
—
—
—
0
0
0
28
0.00
0.99
0.0
1.4
—
—
—
0
0
0
32
0.00
0.96
0.0
3.1
—
108.82
—
0
20
11
181
0.57
0.96
6.5
4.4
343.91
248.06
u/l
0.61
11
170
98
881
1.37
0.92
5.6
4.4
13.73
14.28
mm/h
0.13
91
813
84
744
1.32
0.84
6.1
5.2
6.95
6.73
mmol/l
0.45
79
714
0
24
0.00
0.80
0.0
4.5
—
—
—
0
0
0
27
0.00
0.78
0.0
1.2
—
—
—
0
0
120
1126
1.44
0.78
6.6
6.2
2.51
2.56
mmol/l
0.25
109
1019
116
1083
1.40
0.77
7.2
7.1
39.08
40.27
mmol/mol
1.01
106
1008
117
1098
1.39
0.71
5.6
5.3
4.41
4.48
mmol/l
0.29
106
1002
125
1189
1.45
0.67
12.8
12.6
24.64
24.34
u/l
0.08
117
1151
5
28
1.81
0.67
1.4
1.1
—
—
—
0
0
34
274
1.32
0.65
1.4
1.8
372.10
411.06
pmol/l
0.67
29
232
18
132
1.42
0.61
1.1
1.4
—
—
—
0
0
63
555
1.24
0.59
2.7
2.7
—
—
estimate
—
0
0
119
1131
1.33
0.56
22.6
18.5
21.99
26.82
mg/l
1.40
100
973
46
395
1.24
0.54
1.7
1.8
18.66
20.76
nmol/l
0.40
41
328
30
248
1.27
0.48
1.4
1.8
806.26
1169.29
nmol/l
2.72
23
196
5
32
1.58
0.42
2.0
1.2
—
—
—
0
0
5
33
1.53
0.42
2.0
1.2
—
—
—
0
0
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
5.3
—
27.29
—
0
7
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
17
0.00
0.41
0.0
1.4
—
—
—
0
0
0
17
0.00
0.41
0.0
1.2
—
—
—
0
0
0
18
0.00
0.40
0.0
1.7
—
—
—
0
0
114
1091
1.23
0.40
5.5
5.2
1.38
1.47
mmol/l
1.63
103
986
33
283
1.22
0.39
1.7
1.8
1.69
1.69
mg/l
0.00
25
227
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
6
47
1.29
0.32
2.2
2.6
0.23
0.33
iu/ml
—
6
22
49
449
1.14
0.27
4.3
6.1
11.92
2.29
ug/l
0.50
40
392
17
201
0.82
0.26
1.8
1.3
10.63
44.47
iu/ml
—
8
66
58
539
1.13
0.25
3.1
4.6
26.35
49.63
ng/l
1.53
37
425
97
934
1.12
0.22
8.0
8.3
72.79
82.41
u/l
2.54
91
879
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.9
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
2.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
2.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.8
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
210.55
—
0
12
0
13
0.00
0.21
0.0
1.3
—
6.29
—
0
7
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.9
—
1454.21
—
0
14
6
52
1.16
0.19
1.7
1.1
—
—
—
0
0
7
89
0.78
0.15
1.0
1.8
—
—
—
0
0
49
464
1.09
0.14
3.5
3.5
1980.71
1745.22
ng/l
0.11
42
402
12
137
0.86
0.12
8.0
9.3
—
—
—
0
0
18
198
0.90
0.11
5.2
4.6
1.15
1.05
mmol/l
1.70
18
181
5
47
1.07
0.09
1.6
2.1
—
—
—
0
0
7
82
0.85
0.07
1.0
1.7
—
—
—
0
0
10
89
1.13
0.07
2.3
1.8
—
—
—
0
0
36
351
1.03
0.02
4.8
5.1
24.22
21.52
%
0.33
15
181
15
143
1.05
0.01
1.3
1.5
—
—
—
0
0
26
253
1.03
0.01
1.4
1.3
6.68
1.84
u/ml
—
5
67
59
584
1.02
0.00
7.1
4.6
34.56
34.72
g/l
0.08
51
556
105
1049
1.00
0.00
4.0
4.5
1.27
1.24
mmol/l
0.21
95
939
11
107
1.03
0.00
1.5
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
22.68
—
0
8
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
3.0
—
236.71
—
0
7
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
10.71
—
0
8
0
9
0.00
-0.00
0.0
4.3
—
0.44
—
0
9
0
6
0.00
-0.00
0.0
2.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
59
0.84
-0.00
1.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
99.13
—
0
8
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H8_POSTMASTNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_POSTMASTNAS | 1.322 [1.09, 1.61] | 0.006 |
| Birth year | 0.994 [0.99, 1.0] | 0.194 |
During the follow-up period (1.1.1998 — 31.12.2019), 152 out of 602 females with H8_POSTMASTNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_POSTMASTNAS | 1.037 [0.84, 1.29] | 0.741 |
| Birth year | 0.987 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 142 out of 605 males with H8_POSTMASTNAS died.
Mortality risk
Mortality risk for people of age
years, who have H8_POSTMASTNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.151% | 0.198% |
| 5 | 0.789% | 1.264% |
| 10 | 1.944% | 2.977% |
| 15 | 3.714% | 5.379% |
| 20 | 6.312% | 9.286% |
Relationships between endpoints
↥Index endpoint: H8_POSTMASTNAS – Other disorders following mastoidectomy
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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