labyrinthitis: Inflammation of the inner ear. The cause is often not clear. It may be due to a virus, but it can also arise from bacterial infection, head injury, extreme stress, an allergy, or as a reaction to medication. [ https://en.wikipedia.org/wiki/Labyrinthitis NCIT:C128369 ]
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
143 |
4. Check minimum number of eventsNone |
143 |
5. Include endpointsNone |
143 |
6. Filter based on genotype QC (FinnGen only) |
121 |
Control definitions (FinnGen only)
- Control exclude
- H8_INNER
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H83
- Name in latin
- Labyrinthitis
Similar endpoints
↥List of similar endpoints to
Labyrinthitis
based on the number of shared cases.
Similar with more cases:
- Diseases of inner ear
- Diseases of the ear and mastoid process
- Any prescribed medicine buy
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1255 | 675 | 574 |
| Only index persons | 913 | 513 | 400 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 36.37 | 39.34 | 32.62 |
| Only index persons | 37.48 | 39.64 | 34.71 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 121 | 84 | 37 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.02 |
| Median age at first event (years) | 43.35 | 39.61 | 51.85 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 129
- Matched controls
- 1290
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H83.0
ICD-10 Finland
Labyrinthitis
+∞
106.5
87
*
38403
ICD-8 Finland
Other inflammatory diseases of ear, Labyrinthitis
+∞
42.0
38
*
R42
ICD-10 Finland
Dizziness and giddiness
5.4
19.3
54
151
H81.3
ICD-10 Finland
Other peripheral vertigo
38.9
11.5
14
*
H81.1
ICD-10 Finland
Benign paroxysmal vertigo
5.4
10.2
22
47
H66.0
ICD-10 Finland
Acute suppurative otitis media
4.3
8.8
26
72
H90.4
ICD-10 Finland
Sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
9.6
8.6
17
20
H81.2
ICD-10 Finland
Vestibular neuronitis
84.8
7.5
8
*
H65.0
ICD-10 Finland
Acute serous otitis media
24.0
6.8
9
*
DFF00
NOMESCO Finland
Pure tone audiometry
3.7
6.7
24
76
Z01.1
ICD-10 Finland
Examination of ears and hearing
3.2
6.4
29
107
N07CA01
ATC
betahistine; oral
4.2
6.0
17
45
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
56
348
2.08
3.91
4.5
2.8
31.20
28.53
u/l
0.53
56
328
87
640
2.10
3.79
10.2
9.0
4.10
3.96
e9/l
0.21
74
552
18
70
2.83
3.56
1.8
1.5
—
—
—
0
0
49
311
1.93
3.09
3.4
3.1
0.53
0.29
e6/l
0.40
37
233
23
109
2.35
3.07
7.9
3.1
2.22
1.71
mmol/l
0.46
18
91
5
6
8.60
2.77
1.4
1.0
—
—
—
0
0
28
154
2.05
2.60
2.4
3.1
3.19
3.77
e6/l
0.14
15
79
6
11
5.66
2.57
1.5
1.0
—
—
—
0
0
76
581
1.75
2.46
3.8
4.0
0.00
0.00
estimate
-0.00
20
119
6
12
5.18
2.43
1.5
1.1
—
—
—
0
0
6
12
5.18
2.43
1.5
1.1
—
—
—
0
0
31
183
1.91
2.36
6.1
3.3
111.31
258.55
ng/l
0.55
26
137
75
577
1.72
2.32
3.8
4.0
0.00
0.00
estimate
-0.00
19
118
76
589
1.71
2.27
3.8
4.0
0.00
0.00
estimate
-0.00
20
114
8
25
3.34
2.13
1.8
1.2
—
—
—
0
0
28
166
1.88
2.10
3.5
2.0
—
—
—
0
0
22
120
2.00
2.09
3.4
1.8
—
—
—
0
0
8
26
3.21
2.05
1.6
1.2
320.13
449.54
mg/l
—
8
26
112
984
2.05
2.05
4.8
4.9
5.72
5.86
mmol/l
0.62
102
891
86
700
1.69
2.04
4.5
3.1
44.78
43.61
u/l
0.05
78
663
21
114
2.01
2.02
3.9
1.9
—
—
—
0
0
6
16
3.88
1.96
2.2
1.8
—
—
—
0
0
12
52
2.44
1.94
2.2
1.8
—
—
—
0
0
7
22
3.30
1.91
1.1
1.0
—
—
—
0
0
7
22
3.30
1.91
1.7
1.1
3.34
3.79
mmol/l
—
7
22
5
12
4.29
1.84
2.6
2.3
—
—
—
0
0
5
12
4.29
1.84
2.6
1.4
—
—
—
0
0
5
12
4.29
1.84
2.6
2.3
—
—
—
0
0
39
267
1.66
1.78
3.4
2.3
—
—
—
0
0
39
267
1.66
1.78
2.8
4.0
1.02
1.02
kg/l
0.09
26
182
19
107
1.91
1.65
2.4
2.4
465.37
384.91
nmol/l
0.46
19
101
5
14
3.67
1.63
1.2
2.1
—
—
—
0
0
7
27
2.68
1.54
2.6
1.8
—
—
—
0
0
7
27
2.68
1.54
2.4
1.6
—
—
—
0
0
27
174
1.70
1.53
2.7
3.0
2.36
0.93
e6/l
1.19
15
98
6
21
2.94
1.52
2.7
1.1
—
—
—
0
0
7
28
2.58
1.47
3.4
1.8
—
—
—
0
0
7
28
2.58
1.47
5.0
1.1
0.00
0.00
g/l
—
7
28
19
112
1.82
1.45
3.5
2.1
34.16
28.62
u/l
0.32
19
89
94
817
1.55
1.40
6.0
3.9
13.90
11.32
mm/h
0.83
89
736
15
83
1.91
1.38
5.4
3.3
84.57
77.14
ng/l
0.13
15
71
8
34
2.44
1.32
1.9
3.0
—
—
—
0
0
8
35
2.37
1.29
1.5
1.1
—
5.57
—
0
6
13
71
1.92
1.24
3.1
3.8
4.50
4.50
pmol/l
0.01
13
62
5
19
2.69
1.22
1.8
2.0
—
—
—
0
0
106
958
1.60
1.21
6.2
6.2
39.37
39.06
mmol/mol
0.13
98
887
112
1026
1.70
1.21
6.3
5.5
2.98
2.68
mmol/l
3.24
101
947
57
458
1.44
1.20
3.7
3.7
0.00
0.01
estimate
0.50
16
100
5
20
2.56
1.16
2.0
1.4
3.92
6.79
u/ml
—
5
20
5
20
2.56
1.16
2.0
1.9
—
—
—
0
0
19
121
1.67
1.13
3.8
6.0
0.76
0.95
mmol/l
0.15
14
101
13
74
1.84
1.11
1.5
1.2
12.00
158.43
u/ml
—
5
29
7
35
2.06
1.01
2.4
1.4
0.23
0.23
g/l
—
7
35
7
36
2.00
0.98
2.4
1.4
1.16
1.19
g/l
—
7
36
0
32
0.00
0.96
0.0
1.7
—
—
—
0
0
28
204
1.48
0.96
1.7
1.3
41.29
38.56
iu/ml
—
8
51
107
985
1.51
0.95
7.1
5.6
1.81
1.85
mu/l
0.15
102
908
61
512
1.36
0.94
2.9
2.4
79.68
77.04
nmol/l
0.24
52
457
6
28
2.20
0.93
4.3
2.1
220.33
164.89
%
—
6
28
11
64
1.79
0.89
7.6
2.8
24.75
23.93
mmol/l
0.78
11
64
6
31
1.98
0.85
1.5
1.6
—
—
—
0
0
11
65
1.76
0.85
6.2
2.4
0.59
0.66
%
0.36
11
65
78
689
1.33
0.82
4.1
3.4
—
—
—
0
0
11
66
1.73
0.81
6.2
2.5
0.87
1.42
%
1.58
11
66
48
396
1.34
0.81
6.5
3.8
26.07
36.91
ng/l
0.53
31
285
111
1039
1.49
0.79
29.1
14.8
24.64
23.05
mg/l
0.21
99
841
31
239
1.39
0.79
2.1
1.6
—
—
—
0
0
0
26
0.00
0.79
0.0
1.5
—
46.99
—
0
26
106
985
1.43
0.78
23.4
14.9
80.75
82.38
ml/min/173m2
0.27
94
912
108
1009
1.43
0.75
5.3
4.8
1.46
1.51
mmol/l
0.63
102
928
7
39
1.84
0.74
1.4
1.2
—
—
—
0
0
7
40
1.79
0.72
1.4
1.2
—
—
—
0
0
108
1012
1.41
0.70
5.7
4.9
4.87
4.63
mmol/l
1.77
103
939
41
337
1.32
0.70
3.6
3.1
0.00
0.00
estimate
-0.00
16
96
7
43
1.66
0.68
1.6
1.7
—
—
—
0
0
41
339
1.31
0.67
3.9
3.9
0.00
0.00
estimate
-0.00
19
104
5
28
1.82
0.67
1.0
1.1
—
20.26
—
0
5
60
522
1.28
0.67
3.6
2.8
—
—
estimate
—
0
0
24
185
1.37
0.62
1.6
1.3
7.58
7.53
u/ml
—
8
73
11
72
1.58
0.61
1.9
1.3
—
—
—
0
0
6
38
1.61
0.55
2.7
1.3
—
—
—
0
0
6
40
1.52
0.52
2.0
2.0
—
—
—
0
0
6
40
1.52
0.52
1.7
1.3
—
—
—
0
0
102
964
1.28
0.49
4.8
4.0
1.32
1.23
mmol/l
0.61
96
878
36
306
1.24
0.47
1.4
1.3
0.65
1.51
u/ml
—
8
86
49
431
1.22
0.47
2.0
2.0
1.32
1.36
mmol/l
0.12
43
355
17
217
0.75
0.46
1.5
1.5
—
—
—
0
0
10
70
1.46
0.43
1.1
1.0
—
—
—
0
0
5
32
1.58
0.42
45.8
1.6
104.20
96.03
%
—
5
32
39
342
1.20
0.38
3.4
3.9
13.48
7.13
mg/mmol
0.39
25
211
6
42
1.45
0.36
2.3
2.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
2.0
—
0.17
—
0
6
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
42
390
1.11
0.18
3.2
3.0
2.34
2.36
mmol/l
0.36
37
354
17
149
1.16
0.16
2.9
2.0
—
—
—
0
0
7
88
0.78
0.15
2.4
2.0
—
—
—
0
0
9
105
0.85
0.13
2.2
2.2
—
—
—
0
0
12
104
1.17
0.13
2.2
3.4
—
—
—
0
0
50
476
1.08
0.13
2.5
2.0
101.07
97.34
pmol/l
0.16
27
238
18
165
1.11
0.09
3.3
2.3
—
—
—
0
0
18
166
1.10
0.08
3.9
4.2
19.46
24.69
%
—
9
77
8
75
1.07
0.07
1.5
1.4
—
—
—
0
0
12
125
0.96
0.00
7.7
6.9
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
3.4
—
—
—
0
0
0
9
0.00
0.00
0.0
3.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.6
—
14.50
—
0
9
5
59
0.84
-0.00
3.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.7
—
13.95
—
0
6
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.0
—
4.62
—
0
6
0
7
0.00
-0.00
0.0
1.4
—
55.93
—
0
7
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
0.32
—
0
6
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.7
—
20.18
—
0
6
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
0.26
—
0
5
0
6
0.00
-0.00
0.0
3.0
—
9.75
—
0
6
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H8_LABYRINTHITIS and mortality.
Females
No dataMales
No dataMortality risk
Mortality risk for people of age
years, who have H8_LABYRINTHITIS.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | No data |
| 5 | No data | No data |
| 10 | No data | No data |
| 15 | No data | No data |
| 20 | No data | No data |
Relationships between endpoints
↥Index endpoint: H8_LABYRINTHITIS – Labyrinthitis
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data