Labyrinthine fistula

H8_LABYRFISTU

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H83.1 Cause of death: ICD-10 — H83.1 2 out of 7 registries used, show all original rules.	116
4. Check minimum number of events None	116
5. Include endpoints None	116
6. Filter based on genotype QC (FinnGen only)	105

Control definitions (FinnGen only)

Control exclude: H8_INNER

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: H83
Name in latin: Fistula labyrinthi

NAME	H8_LABYRFISTU
CONTROL_EXCLUDE	H8_INNER
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H831
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H831
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Labyrinthine fistula based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	700	312	387
Only index persons	674	299	375
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	52.09	53.73	50.77
Only index persons	51.93	53.52	50.66

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	105	45	60
Unadjusted period prevalence (%)	0.02	0.02	0.03
Median age at first event (years)	52.63	48.46	55.76

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
109: Matched controls
1090

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

H83.1

ICD-10 Finland

Labyrinthine fistula

+∞

157.2

109

N07CA01

ATC

betahistine; oral

12.0

26.4

DFD20

NOMESCO Finland

Closure of rupture of round window

+∞

23.8

R42

ICD-10 Finland

Dizziness and giddiness

6.9

22.7

141

DFF00

NOMESCO Finland

Pure tone audiometry

8.0

22.2

H81.3

ICD-10 Finland

Other peripheral vertigo

60.8

21.2

UDC00

NOMESCO Finland

Ear microscopy

7.7

18.1

H90.3

ICD-10 Finland

Sensorineural hearing loss, bilateral

5.4

16.3

130

H91.2

ICD-10 Finland

Sudden idiopathic hearing loss

34.5

15.8

H90.4

ICD-10 Finland

Sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side

12.9

15.1

H81.0

ICD-10 Finland

Ménière disease

172.1

14.9

H81.1

ICD-10 Finland

Benign paroxysmal vertigo

7.6

13.9

Z01.1

ICD-10 Finland

Examination of ears and hearing

5.4

13.5

H71

ICD-10 Finland

Cholesteatoma of middle ear

37.0

13.0

DFF59

NOMESCO Finland

Other assessment of balance

79.4

12.9

DFD30

NOMESCO Finland

Closure of perilymphatic fistula

+∞

12.7

H80.0

ICD-10 Finland

Otosclerosis involving oval window, nonobliterative

+∞

11.7

DC1AD

NOMESCO Finland

Temporalbone CT

39.7

11.6

H90.7

ICD-10 Finland

Mixed conductive and sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side

36.5

10.6

DDA00

NOMESCO Finland

Stapedotomy

+∞

10.6

H90.1

ICD-10 Finland

Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side

60.5

9.8

H80.9

ICD-10 Finland

Otosclerosis, unspecified

+∞

9.5

ZXC10

NOMESCO Finland

Use of laser

14.4

8.6

H90.6

ICD-10 Finland

Mixed conductive and sensorineural hearing loss, bilateral

24.2

8.2

DCA30

NOMESCO Finland

Exploration of middle ear

48.6

7.8

H93.1

ICD-10 Finland

Tinnitus

5.1

7.8

AA1AD

NOMESCO Finland

CT of head and brain

3.0

7.3

224

DE2CG

NOMESCO Finland

Acoustic channel extensive MRI examination with high intensity magnet

21.8

7.3

H80.8

ICD-10 Finland

Other otosclerosis

+∞

6.3

DAX00

NOMESCO Finland

Adjustment or review of hearing aid

4.5

6.1

DAX08

NOMESCO Finland

Fitting of hearing aid

4.1

6.1

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

116

3.49

7.45

5.1

31.74

32.95

0.22

(3019225) pH of Specimen

3.57

6.66

4.0

4.6

7.38

7.35

0.39

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

420

2.18

3.85

4.5

4.2

28.92

34.41

ng/l

0.28

305

(3032080) INR in Blood by Coagulation assay

472

1.86

2.55

10.6

14.0

1.21

1.26

inr

0.36

389

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

333

1.79

2.26

3.1

3.8

2127.37

1333.56

ng/l

0.41

292

(3044927) Protein electrophoresis panel - Urine

5.76

2.23

1.0

1.1

—

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

446

1.77

2.22

4.2

6.9

1.22

1.21

mmol/l

0.16

411

(3017732) Neutrophils [#/volume] in Blood

135

2.00

2.13

2.2

3.0

3.99

6.30

e9/l

0.70

119

(4034850) Laboratory test

2.97

2.05

2.9

14.2

—

(42870588) Differential panel, method unspecified - Blood

341

1.73

2.04

3.9

6.3

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

605

1.77

1.99

3.7

5.0

6.42

6.68

mmol/l

0.67

571

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

103

939

2.76

1.96

17.1

17.0

20.66

23.59

mg/l

0.43

784

(3004616) Nuclear Ab [Presence] in Serum

3.67

1.86

1.3

1.1

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

2.63

1.78

1.3

1.9

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

108

1.92

1.63

4.4

9.1

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

3.69

1.63

1.6

1.1

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

463

1.60

2.4

2.9

—

estimate

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

493

1.60

1.58

5.8

7.7

1.22

1.21

mmol/l

0.42

432

(3029338) Protein.monoclonal band 3 [Mass/volume] in Serum or Plasma by Electrophoresis

0.00

1.56

0.0

3.0

—

0.00

—

(3044290) Cell count panel - Cerebral spinal fluid

3.44

1.54

1.2

1.1

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

2.35

1.51

1.3

1.2

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

228

1.64

1.49

2.2

2.5

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

2.42

1.47

1.4

2.2

—

(1761868) Lipid panel - Serum or Plasma

407

0.61

1.46

3.2

3.3

—

(3049717) Cytology report of Urine Cyto stain

2.36

1.44

2.7

2.9

—

(3022313) Gas panel - Capillary blood

2.19

1.32

3.0

4.3

—

(3021960) Folate [Moles/volume] in Serum or Plasma

307

1.54

1.30

1.7

12.76

22.06

nmol/l

6.49

257

(3007853) Bacteria identified in Skin by Aerobe culture

118

1.74

1.25

1.7

1.6

—

(4024509) Urine culture

2.25

1.24

2.3

1.6

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

675

1.55

1.22

3.0

3.4

39.09

50.80

u/l

1.20

640

(3026008) Bacteria identified in Urine by Culture

278

1.50

1.14

3.8

3.0

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

2.44

1.10

1.4

1.6

—

(3013707) Erythrocyte sedimentation rate [Velocity] in Red Blood Cells by Westergren method

725

1.53

1.09

4.8

4.5

9.92

11.67

mm/h

0.55

675

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.83

0.97

1.2

—

(3018677) aPTT in Platelet poor plasma by Coagulation assay

162

1.53

0.94

1.7

2.3

27.58

29.28

1.11

156

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.67

0.93

1.8

1.5

—

(3000764) Benzodiazepines [Presence] in Urine

2.13

0.91

1.0

1.5

—

(3027944) Amphetamines [Presence] in Urine

2.13

0.91

1.0

1.4

—

(3027008) Opiates [Presence] in Urine

2.06

0.88

1.0

1.5

—

(3028300) Cannabinoids [Presence] in Urine

2.06

0.88

1.0

1.5

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

202

1.45

0.83

1.8

1.9

401.86

462.31

pmol/l

0.61

169

(3022096) Basophils/Leukocytes in Blood

486

1.36

0.82

4.7

6.8

0.84

0.67

1.58

456

(3001122) Ferritin [Mass/volume] in Serum or Plasma

450

1.35

0.77

3.5

3.1

191.60

131.78

ug/l

0.38

422

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

178

1.45

0.77

1.4

1.2

23.41

4.84

u/ml

0.43

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

270

0.68

0.77

3.1

3.2

0.70

0.75

ug/l

0.21

181

(3011397) Hemoglobin [Presence] in Urine by Test strip

233

0.68

0.71

4.9

4.1

—

0.40

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

915

1.55

0.67

6.4

6.6

38.34

39.50

mmol/mol

0.67

867

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

938

1.60

0.67

6.0

5.3

1.44

mmol/l

0.04

877

(3006504) Eosinophils/Leukocytes in Blood

490

1.29

0.63

4.5

6.7

2.65

2.86

0.33

462

(3016879) Cocaine [Presence] in Urine

1.70

0.62

1.0

1.5

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

114

0.59

0.62

3.4

2.0

445.57

366.86

nmol/l

—

103

(44790048) Parainfluenza type 2 nucleic acid detection

0.00

0.61

0.0

1.4

—

(44790047) Parainfluenza type 1 nucleic acid detection

0.00

0.61

0.0

1.4

—

(44790049) Parainfluenza type 3 nucleic acid detection

0.00

0.61

0.0

1.4

—

(3035933) Granulocytes/Leukocytes in Blood

0.00

0.61

0.0

2.7

—

59.87

—

(44806118) Parainfluenza type 4 nucleic acid detection

0.00

0.61

0.0

1.4

—

(3010130) Cytomegalovirus IgG Ab [Units/volume] in Serum or Plasma

0.00

0.61

0.0

1.2

—

120.33

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

0.00

0.60

0.0

1.2

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

942

1.56

0.60

6.0

5.4

4.53

4.56

mmol/l

0.08

884

(3019069) Monocytes/Leukocytes in Blood

492

1.28

0.60

4.7

6.8

8.55

8.73

0.20

465

(40758558) Short blood count panel - Blood

310

0.75

0.57

6.5

6.3

—

(3018010) Neutrophils/Leukocytes in Blood

494

1.27

0.57

4.5

6.6

59.24

57.72

0.41

472

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

1.57

0.56

2.7

3.1

4.04

4.43

pmol/l

—

(3013115) Eosinophils [#/volume] in Blood

555

1.27

0.56

4.3

7.1

0.18

0.19

e9/l

0.28

486

(3031040) Bacteria [#/volume] in Urine by Automated count

636

1.28

0.56

5.3

4.5

—

3971.50

—

(3019309) Folate [Moles/volume] in Red Blood Cells

180

1.35

0.56

2.0

1.7

1230.13

1283.58

nmol/l

0.10

138

(3019060) Gas panel - Arterial blood

1.47

0.54

2.0

4.4

—

(40768443) Skin Pathology biopsy report

1.59

0.50

1.7

1.3

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

441

1.25

0.49

4.2

5.2

36.89

35.37

g/l

1.53

422

(3028026) IgM [Mass/volume] in Serum or Plasma

0.58

0.48

1.2

1.9

0.46

1.23

g/l

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

127

0.68

0.46

1.4

1.9

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

130

0.66

0.46

1.4

1.8

—

(3014111) Lactate [Moles/volume] in Serum or Plasma

0.61

0.44

1.0

7.6

1.42

1.57

mmol/l

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.41

0.0

2.5

—

3.39

—

(3015916) Alpha-1-Fetoprotein [Units/volume] in Serum or Plasma

0.00

0.41

0.0

2.8

—

6.75

—

(3009041) Cardiolipin IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.41

0.0

1.4

—

4.63

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

0.40

0.0

1.6

—

15.85

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

589

1.21

0.39

3.0

—

(3002030) Lymphocytes/Leukocytes in Blood

500

1.20

0.38

4.5

6.8

27.13

27.51

0.11

475

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

723

1.22

0.38

4.6

4.1

14.61

14.87

pmol/l

0.36

661

(3001604) Monocytes [#/volume] in Blood

541

1.20

0.37

4.3

6.8

0.56

0.58

e9/l

0.25

464

(3009508) Creatinine [Moles/volume] in Urine

344

1.21

0.37

2.7

3.4

8.75

7.94

mmol/l

0.49

297

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

442

1.20

0.37

1.9

2.1

90.16

96.04

pmol/l

0.42

235

(3018418) pH of Serum or Plasma

304

0.81

0.37

3.0

4.8

7.39

7.40

0.04

212

(3006315) Basophils [#/volume] in Blood

542

1.19

0.36

4.3

6.8

0.05

0.04

e9/l

1.08

463

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

447

0.83

0.36

2.9

2.6

76.81

77.52

nmol/l

0.06

402

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

958

1.36

0.34

6.6

6.1

2.57

2.66

mmol/l

0.45

901

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.35

0.34

1.3

2.0

—

(3001334) Neutrophil cytoplasmic Ab [Units/volume] in Serum

1.35

0.34

1.7

1.4

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

327

1.20

0.34

4.8

3.5

2.36

2.35

mmol/l

0.18

294

(3005719) IgG [Mass/volume] in Serum or Plasma

0.69

0.32

1.7

2.5

9.49

10.34

g/l

—

(3041096) Erythrocytes [Presence] in Urine by Automated

300

0.82

0.32

4.3

3.4

0.00

estimate

—

104

(3023420) DNA double strand Ab [Units/volume] in Serum

1.34

0.31

1.1

1.8

—

3.51

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

351

0.84

0.31

5.2

5.0

18.93

22.01

0.86

173

(3044640) Blood type and Crossmatch panel - Blood

311

1.18

0.30

1.9

2.5

—

(3015736) pH of Urine

419

1.17

0.30

4.3

3.7

6.04

6.19

0.48

223

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

429

1.17

0.29

1.8

2.0

1.36

1.34

mmol/l

0.07

355

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.31

0.29

1.5

1.7

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

150

1.24

0.28

1.5

1.6

—

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

236

1.19

0.28

1.6

1.7

0.59

1.24

mg/l

1.84

188

(3012516) Albumin [Mass/volume] in Urine

323

1.17

0.28

2.8

3.5

16.21

70.93

mg/l

2.72

217

(3037522) Nuclear Ab [Titer] in Serum

151

1.23

0.27

1.4

192.00

456.59

titre

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

910

1.24

0.26

5.1

4.4

1.24

1.28

mmol/l

0.22

846

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.22

0.26

1.4

1.5

—

(40761536) Microorganisms panel - Urine sediment

0.69

0.25

3.7

3.6

—

(3023368) Bacteria identified in Blood by Culture

292

0.86

0.23

3.2

4.4

—

(3027801) Oxygen [Partial pressure] in Arterial blood

124

0.79

0.23

2.1

8.0

10.48

10.94

kpa

—

119

(3014051) Protein [Presence] in Urine by Test strip

281

0.86

0.23

4.6

3.1

—

0.22

—

(4035726) Immunohistochemistry procedure

1.26

0.22

1.6

1.3

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.20

0.22

1.0

1.3

—

(3000330) Specific gravity of Urine by Test strip

1.20

0.22

11.0

4.5

1.02

ratio

—

(3027529) Toxoplasma gondii IgM Ab [Units/volume] in Serum

0.00

0.21

0.0

1.3

—

(4281824) Cell count and differential, peritoneal fluid

0.00

0.21

0.0

1.1

—

(3045142) Bone marrow Pathology biopsy report

0.00

0.21

0.0

1.5

—

(4062490) Immunoglobulin typing, IgG

0.00

0.21

0.0

1.3

—

(3018301) Testosterone Free [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.4

—

195.48

—

(3021125) Hepatitis C virus RNA [Presence] in Serum or Plasma by NAA with probe detection

0.00

0.21

0.0

1.6

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

0.21

0.0

1.1

—

(3045788) Cell count panel - Pleural fluid

0.00

0.21

0.0

1.1

—

(3012413) Glucose [Moles/volume] in Serum or Plasma --2 hours post meal

0.00

0.21

0.0

1.3

—

10.12

—

(36660697) Celiac disease serology panel - Serum

1.28

0.21

1.4

1.2

—

(3051014) Leukocytes [#/area] in Urine sediment by Automated count

0.00

0.21

0.0

2.4

—

4.20

—

(4268621) Lupus anticoagulant assay

0.00

0.21

0.0

2.3

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

925

1.21

0.21

5.6

5.1

5.92

5.99

mmol/l

0.30

863

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

873

1.18

0.21

6.0

5.0

1.69

1.96

mu/l

2.10

806

(4146454) Self-monitoring of blood glucose

0.00

0.21

0.0

2.8

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

0.00

0.21

0.0

4.3

—

(3032155) Metanephrine Free [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.2

—

0.19

—

(40768795) Lymph node Pathology biopsy report

0.00

0.21

0.0

1.1

—

(21494434) Karyotype in Bone marrow

0.00

0.21

0.0

1.2

—

(3044355) Beta 2 glycoprotein 1 IgG Ab [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.20

0.0

1.4

—

1.17

—

(3035715) Granulocytes [#/volume] in Blood

0.00

0.20

0.0

2.2

—

4.65

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.20

0.0

1.2

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

0.20

0.0

1.2

—

(3002256) Pathology report gross observation

122

0.80

0.20

1.6

1.2

—

(3022145) Colonoscopy Study observation

132

0.81

0.19

1.1

1.4

—

(40764999) Glomerular filtration rate [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)/1.73 sq M

927

1.19

0.19

16.2

16.9

78.55

80.57

ml/min/173m2

0.47

861

(3042936) Bacteria identified in Isolate by Culture

163

0.84

0.19

1.5

1.8

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

0.75

0.17

3.6

1.5

—

(3020682) Albumin/Creatinine [Ratio] in Urine

334

1.12

0.16

3.3

4.3

1.71

11.09

mg/mmol

3.95

223

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

443

1.11

0.16

6.1

5.7

1.94

2.77

ug/l

0.54

397

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

375

1.11

0.15

3.6

3.4

—

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

102

1002

1.28

0.15

12.5

12.6

24.34

26.13

u/l

0.82

982

(40760892) CBC W Ordered Manual Differential panel - Blood

242

0.89

0.15

3.7

6.0

—

(21494755) Public health laboratory ask at order entry panel

1.21

0.14

1.3

—

(40768804) Tissue Pathology biopsy report

386

1.10

0.14

2.8

2.1

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

403

0.91

0.13

4.6

4.1

0.00

0.04

estimate

—

113

(3019150) Specific gravity of Urine by Refractometry

221

1.11

0.12

3.8

4.7

1.02

kg/l

0.04

138

(3017446) Testosterone [Moles/volume] in Serum or Plasma

115

0.86

0.11

1.9

2.8

14.24

13.82

nmol/l

—

110

(46235355) HIV 1 and 2 tests - Meaningful Use set

187

0.89

0.11

1.6

1.9

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

174

1.11

0.10

1.4

1.6

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.16

0.10

1.4

2.7

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.14

0.09

1.3

2.1

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

1.08

0.08

1.1

3.0

0.73

0.64

—

(3035995) Alkaline phosphatase [Enzymatic activity/volume] in Serum or Plasma

774

1.08

0.08

7.2

8.8

72.93

78.24

u/l

1.17

737

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.06

0.08

1.1

3.0

1.33

1.37

—

(3035350) Ketones [Presence] in Urine by Test strip

526

0.94

0.07

4.9

4.2

0.00

12.79

estimate

—

127

(4010399) Spirometry for bronchospasm with prolonged evaluation after bronchodilator

0.82

0.07

1.3

1.4

—

(3000492) Spirometry study

100

0.89

0.06

1.7

1.4

—

(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma

103

0.86

0.06

1.4

3.3

4.67

8.62

umol/l

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

596

1.05

0.06

7.6

11.4

4.02

4.13

e9/l

0.13

524

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

110

0.90

0.05

3.5

4.0

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

150

0.92

0.04

3.4

7.4

105.57

103.88

mmol/l

0.93

150

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

170

1.07

0.04

1.6

2.0

—

(3000494) Fungus identified in Specimen by Culture

119

0.92

0.04

1.5

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

539

1.04

0.04

6.1

7.2

11.29

11.82

umol/l

0.24

514

(3029937) Albumin [Presence] in Urine by Test strip

310

0.96

0.03

4.2

0.00

0.02

estimate

—

111

(3012544) pH of Venous blood

108

0.92

0.03

2.8

4.3

7.40

7.39

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

107

0.93

0.02

1.6

2.0

—

(3009261) Glucose [Presence] in Urine by Test strip

538

0.97

0.02

4.7

4.2

0.00

estimate

—

116

(3017143) Hepatitis C virus Ab [Presence] in Serum

127

0.94

0.02

1.4

1.6

—

(3007164) IgA [Mass/volume] in Serum or Plasma

224

1.03

0.00

1.3

1.5

2.52

2.49

g/l

0.03

138

(3003694) ABO and Rh group [Type] in Blood

274

1.03

0.00

1.4

—

(3021601) Nitrite [Presence] in Urine by Test strip

526

0.98

0.00

4.8

4.1

0.00

estimate

—

123

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.03

0.00

1.2

1.5

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.03

0.00

1.6

1.8

—

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

259

1.01

0.00

2.0

2.1

2.49

2.71

mg/l

0.30

230

(3026493) Urate [Moles/volume] in Serum or Plasma

275

1.02

0.00

2.5

3.1

325.00

358.17

umol/l

0.83

242

(40768797) Stomach Pathology biopsy report

125

0.96

0.00

1.2

1.3

—

(40761511) CBC panel - Blood by Automated count

969

1.01

0.00

18.0

15.0

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

109

1.01

0.00

1.7

1.4

—

(40765096) Chromosome analysis panel by Banding

0.00

-0.00

0.0

1.2

—

(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

2.4

—

252.63

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

-0.00

0.0

11.0

—

6.00

—

(37208534) Antinuclear antibody arbitrary concentration in serum

0.00

-0.00

0.0

1.0

—

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

0.92

-0.00

1.4

2.6

0.24

0.22

g/l

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

-0.00

0.0

6.7

—

155.10

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

0.98

-0.00

1.2

1.1

—

(37020957) Sapovirus genogroups I+II+IV+V RNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.8

—

(42869547) Procollagen type III.N-terminal propeptide [Mass/volume] in Serum

0.00

-0.00

0.0

1.4

—

11.12

—

(42869457) Rotavirus RNA [Identifier] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.8

—

(3019897) Erythrocyte [DistWidth] in Red Blood Cells by Automated count

0.00

-0.00

0.0

1.8

—

13.20

—

(3017569) Oxygen content in Arterial blood

0.00

-0.00

0.0

11.0

—

16.24

—

(40758897) Direct antiglobulin test.IgG specific reagent [Presence] on Red Blood Cells

0.00

-0.00

0.0

3.2

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

-0.00

0.0

4.2

—

9.82

—

(3006922) Hepatitis E virus Ab [Presence] in Serum

0.00

-0.00

0.0

1.0

—

(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay

0.00

-0.00

0.0

3.2

—

100.40

—

(3002079) Sodium [Moles/time] in 24 hour Urine

0.00

-0.00

0.0

1.2

—

158.11

—

(3027953) Aldolase [Enzymatic activity/volume] in Serum or Plasma

0.00

-0.00

0.0

1.7

—

10.43

—

(3047189) Immunofixation for 24 hour Urine

0.00

-0.00

0.0

2.0

—

(3019832) Treponema pallidum Ab [Presence] in Serum

0.98

-0.00

1.7

1.6

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

-0.00

0.0

1.0

—

(3033799) Differential panel - Peritoneal fluid

0.00

-0.00

0.0

1.0

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

-0.00

0.0

1.1

—

(3026470) Cobalt [Mass/volume] in Blood

0.00

-0.00

0.0

2.8

—

4.67

—

(21491868) Cryoglobulin [Mass/volume] in Serum

0.00

-0.00

0.0

1.0

—

(3016724) Homocysteine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.7

—

13.16

—

(3008536) Aspergillus sp Ab [Presence] in Serum

0.00

-0.00

0.0

1.2

—

(21493690) Lymphocyte T-cell and B-cell and Natural killer subsets panel - Blood

0.00

-0.00

0.0

2.9

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

-0.00

0.0

1.6

—

(3029715) Chromosome analysis.interphase [Interpretation] in Bone marrow by FISH Narrative

0.00

-0.00

0.0

1.0

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

-0.00

0.0

4.2

—

4.62

—

(40758895) Direct antiglobulin test.complement C3d specific reagent [Presence] on Red Blood Cells

0.00

-0.00

0.0

3.2

—

(3025577) Chromium [Mass/volume] in Blood

0.00

-0.00

0.0

2.8

—

2.44

—

(3014271) Vancomycin [Susceptibility]

0.00

-0.00

0.0

1.8

—

(3009595) Pneumocystis jirovecii DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.8

—

(3035320) C reactive protein [Mass/volume] in Body fluid

0.00

-0.00

0.0

1.4

—

54.56

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.00

-0.00

0.0

1.0

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

-0.00

0.0

1.0

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

-0.00

0.0

3.6

—

1.00

—

(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.8

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

-0.00

0.0

1.1

—

(40768441) Liver Pathology biopsy report

0.00

-0.00

0.0

1.3

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

-0.00

0.0

1.4

—

(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.8

—

(3005757) Coagulation factor V activity actual/normal in Platelet poor plasma by Coagulation assay

0.00

-0.00

0.0

1.4

—

97.14

—

Mortality – FinRegistry

↥

Association

Association between endpoint H8_LABYRFISTU and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have H8_LABYRFISTU.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: H8_LABYRFISTU – Labyrinthine fistula

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Labyrinthine fistula

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints