—
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
213 |
4. Check minimum number of eventsNone |
213 |
5. Include endpointsNone |
213 |
6. Filter based on genotype QC (FinnGen only) |
192 |
Control definitions (FinnGen only)
- Control exclude
- H8_INNER
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other specified/unspecified diseases of inner ear
based on the number of shared cases.
Similar with more cases:
- Diseases of inner ear
- Diseases of the ear and mastoid process
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1376 | 700 | 666 |
| Only index persons | 1255 | 656 | 599 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 68.30 | 67.86 | 68.62 |
| Only index persons | 67.10 | 67.22 | 66.97 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 192 | 97 | 95 |
| Unadjusted period prevalence (%) | 0.04 | 0.03 | 0.04 |
| Median age at first event (years) | 63.34 | 56.84 | 69.98 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 199
- Matched controls
- 1990
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H83.9
ICD-10 Finland
Disease of inner ear, unspecified
+∞
195.5
154
*
Z01.1
ICD-10 Finland
Examination of ears and hearing
15.7
88.6
113
154
Z46.1
ICD-10 Finland
Fitting and adjustment of hearing aid
12.4
57.4
69
82
R5599
NOMESCO Finland
Other rehabilitation service
21.7
53.9
43
25
Z97.4
ICD-10 Finland
Presence of external hearing-aid
12.9
52.5
59
63
H83.8
ICD-10 Finland
Other specified diseases of inner ear
605.6
49.6
47
*
Z3229
NOMESCO Finland
Other healthcare associate professional
10.0
45.2
62
86
DFF00
NOMESCO Finland
Pure tone audiometry
8.3
41.3
69
120
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
8.9
35.3
51
74
N07CA01
ATC
betahistine; oral
8.2
30.9
47
72
H90.4
ICD-10 Finland
Sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
12.5
29.4
31
29
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
5.7
26.7
64
154
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
4.0
18.3
70
237
DFF15
NOMESCO Finland
Speech audiometry
6.4
17.6
32
58
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
5.1
15.0
35
80
R42
ICD-10 Finland
Dizziness and giddiness
3.4
14.2
68
262
RD211, ,
NOMESCO Finland
6.4
14.1
25
44
R5130
NOMESCO Finland
Repair work or maintenance done on the aid
6.2
13.7
25
45
UDC00
NOMESCO Finland
Ear microscopy
4.8
13.0
32
76
R1260
NOMESCO Finland
Evaluation of communicative skills
13.6
13.0
22
18
H81.3
ICD-10 Finland
Other peripheral vertigo
34.6
12.8
16
5
R5120
NOMESCO Finland
Preparation of an aid
6.4
12.1
21
36
H81.1
ICD-10 Finland
Benign paroxysmal vertigo
5.4
11.8
25
52
DAX00
NOMESCO Finland
Adjustment or review of hearing aid
4.5
11.2
30
76
Z3231
NOMESCO Finland
Registered nurse
2.9
11.2
78
366
R5140
NOMESCO Finland
Monitoring the use of the aid
3.8
11.1
39
121
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
4.4
11.0
30
77
Z00.0
ICD-10 Finland
General medical examination
3.1
10.9
59
240
H93.1
ICD-10 Finland
Tinnitus
4.8
10.7
26
61
TDA90
NOMESCO Finland
Removal wax from ear
12.3
9.2
16
14
H13
ICPC
Plugged feeling ear
2.7
8.3
53
233
H02
ICPC
Hearing complaint
3.0
8.2
43
170
H81.0
ICD-10 Finland
Ménière disease
34.9
8.2
10
*
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
2.7
7.9
51
225
H91.9
ICD-10 Finland
Hearing loss, unspecified
3.9
7.8
24
67
Z46.8
ICD-10 Finland
Fitting and adjustment of other specified devices
7.3
7.5
17
25
DFX03
NOMESCO Finland
Review, maintenance and user education for hearing aid
20.9
7.2
10
5
DAX08
NOMESCO Finland
Fitting of hearing aid
3.4
6.9
26
84
Z71.8
ICD-10 Finland
Other specified counselling
2.2
6.8
80
460
WNF00
NOMESCO Finland
Infection source and contact determination
41.5
6.8
8
*
TQW80
NOMESCO Finland
Local dermatologic skincare
8.3
6.7
14
18
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
2.2
6.3
68
376
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
157
1238
2.27
5.35
22.4
21.0
13.75
13.74
%
0.04
152
1227
50
286
2.00
4.03
4.4
3.0
0.91
0.72
ug/l
0.75
26
186
165
1441
1.85
2.73
19.1
16.8
76.69
79.12
ml/min/173m2
0.68
152
1346
7
15
4.79
2.62
1.0
1.3
—
—
—
0
0
179
1625
2.01
2.33
26.4
25.3
4.40
4.44
e12/l
0.37
170
1592
6
14
4.38
2.16
1.2
1.1
—
—
—
0
0
89
697
1.50
2.08
2.8
2.6
84.41
75.34
nmol/l
1.83
75
621
175
1592
1.82
2.05
23.3
21.9
81.63
80.89
umol/l
0.12
169
1574
170
1535
1.74
2.03
20.3
20.3
3.96
3.99
mmol/l
0.77
164
1506
111
917
1.48
1.95
9.1
9.2
4.20
4.14
e9/l
0.09
93
801
8
181
0.42
1.93
8.9
7.7
—
—
—
0
0
100
813
1.46
1.89
5.8
7.5
1.22
1.21
mmol/l
0.64
91
698
8
28
2.93
1.88
1.3
1.4
—
—
—
0
0
8
28
2.93
1.88
1.3
1.4
—
—
—
0
0
161
1443
1.61
1.87
5.1
5.2
6.05
5.99
mmol/l
0.15
140
1313
167
1511
1.65
1.85
18.4
17.0
26.94
25.08
mg/l
0.26
147
1260
93
748
1.46
1.85
3.2
3.1
164.59
109.50
ug/l
0.54
83
695
110
921
1.43
1.73
3.8
3.2
—
—
—
0
0
7
159
0.42
1.63
1.7
2.1
—
—
—
0
0
15
78
2.00
1.59
2.3
9.4
1.77
1.50
%
0.23
15
73
134
1179
1.42
1.50
4.1
4.3
11.30
12.58
mm/h
0.57
127
1090
10
45
2.29
1.49
1.4
1.3
—
—
—
0
0
137
1215
1.41
1.42
8.4
8.1
73.01
78.26
u/l
0.82
130
1140
130
1145
1.39
1.39
4.9
4.3
14.43
14.81
pmol/l
1.04
119
1049
5
17
2.99
1.36
2.4
1.3
—
—
—
0
0
0
39
0.00
1.35
0.0
1.2
—
—
—
0
0
59
462
1.39
1.29
4.7
3.2
0.56
0.41
e6/l
0.21
40
338
6
25
2.44
1.25
2.3
3.2
32.17
19.36
u/ml
—
6
25
51
393
1.40
1.22
5.2
4.6
20.86
22.98
%
0.41
22
187
6
129
0.45
1.21
1.3
1.4
—
—
—
0
0
152
1389
1.40
1.20
6.3
5.3
2.09
1.88
mu/l
0.71
134
1263
43
326
1.41
1.12
2.3
2.6
2.42
2.45
mmol/l
0.95
30
297
84
713
1.31
1.06
2.3
2.2
98.67
94.45
pmol/l
0.37
40
364
26
181
1.50
1.05
1.4
3.7
5.83
5.71
kpa
0.24
26
172
23
156
1.54
1.04
1.3
2.9
4.09
4.40
kpa
0.38
23
149
33
242
1.44
1.03
3.7
6.3
104.85
104.41
mmol/l
0.19
33
242
26
182
1.49
1.02
3.2
4.3
2.16
46.20
ug/l
0.62
16
150
10
169
0.57
0.93
2.0
2.2
—
—
—
0
0
152
1411
1.33
0.92
4.3
4.3
1.34
1.25
mmol/l
0.95
134
1285
49
394
1.32
0.89
2.8
3.0
328.03
349.06
umol/l
0.80
39
345
160
1498
1.35
0.89
5.9
5.8
2.68
2.64
mmol/l
0.18
140
1380
157
1467
1.33
0.88
5.1
5.1
1.40
1.45
mmol/l
0.69
138
1348
67
565
1.28
0.86
4.1
3.0
2.36
2.35
mmol/l
0.30
55
510
99
876
1.26
0.85
6.1
6.4
10.97
11.83
umol/l
0.70
93
833
36
279
1.35
0.84
4.5
2.9
2.89
0.91
e6/l
0.36
14
149
8
46
1.77
0.83
1.5
1.6
—
—
—
0
0
35
271
1.35
0.82
1.7
2.7
2.33
2.27
g/l
0.27
30
251
10
59
1.73
0.77
1.4
3.1
—
—
—
0
0
29
220
1.37
0.77
2.4
1.8
—
—
—
0
0
40
320
1.31
0.76
5.1
3.6
220.07
415.63
ng/l
0.46
29
267
18
125
1.48
0.76
3.6
4.0
1.23
1.22
mmol/l
0.54
18
113
81
709
1.24
0.75
3.8
4.8
34.55
35.29
g/l
0.53
76
674
151
1415
1.28
0.74
6.6
6.9
39.59
39.99
mmol/mol
0.24
141
1317
5
25
2.02
0.73
2.6
4.4
—
—
—
0
0
59
506
1.24
0.65
2.2
1.7
20.89
20.92
nmol/l
0.00
49
420
0
20
0.00
0.60
0.0
1.7
—
—
—
0
0
0
20
0.00
0.60
0.0
2.8
—
2.08
—
0
20
0
21
0.00
0.60
0.0
1.7
—
—
—
0
0
0
21
0.00
0.60
0.0
1.7
—
—
—
0
0
0
21
0.00
0.60
0.0
1.7
—
—
—
0
0
23
176
1.35
0.59
1.4
3.7
2.39
1.70
mmol/l
0.27
17
149
0
23
0.00
0.58
0.0
1.1
—
—
—
0
0
32
260
1.27
0.55
4.8
3.1
2.11
1.76
e6/l
—
9
132
56
487
1.21
0.54
3.1
3.4
0.00
0.02
estimate
0.74
22
149
6
39
1.55
0.53
1.2
1.5
—
—
—
0
0
58
508
1.20
0.52
8.0
5.6
27.69
2.07
ug/l
0.68
46
449
52
454
1.20
0.48
2.3
2.1
2.44
2.85
mg/l
0.79
42
395
7
47
1.51
0.48
1.1
1.7
—
—
—
0
0
42
362
1.20
0.44
1.8
1.7
0.88
1.31
mg/l
1.22
28
277
34
287
1.22
0.44
2.4
1.9
—
—
—
0
0
5
31
1.63
0.43
1.0
1.1
1.06
1.11
u/ml
—
5
18
13
96
1.38
0.42
1.4
1.4
—
42.16
—
0
11
12
160
0.73
0.41
5.6
3.6
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
2.1
—
—
—
0
0
25
206
1.24
0.40
2.6
1.8
—
—
—
0
0
72
656
1.15
0.40
4.0
4.1
24.57
46.92
ng/l
1.60
53
472
0
19
0.00
0.39
0.0
1.7
—
—
—
0
0
0
19
0.00
0.39
0.0
1.7
—
—
—
0
0
6
42
1.44
0.36
1.0
1.1
—
—
—
0
0
43
380
1.17
0.35
2.1
2.4
—
—
—
0
0
6
47
1.29
0.32
1.7
1.4
—
—
—
0
0
78
725
1.12
0.31
2.5
2.8
—
—
estimate
—
0
0
44
489
0.87
0.31
4.8
3.8
0.00
0.02
estimate
0.74
28
164
8
63
1.28
0.28
1.1
2.2
—
—
—
0
0
5
71
0.70
0.26
1.0
1.3
—
—
—
0
0
17
142
1.22
0.25
2.5
2.0
66.39
65.99
g/l
0.11
17
127
9
76
1.19
0.25
1.0
1.0
—
—
—
0
0
10
78
1.30
0.24
1.3
2.1
—
—
—
0
0
40
362
1.13
0.24
1.3
1.3
0.65
1.80
u/ml
1.27
14
97
28
248
1.15
0.23
1.8
1.5
—
—
—
0
0
5
42
1.20
0.21
1.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
7.50
—
0
10
59
551
1.10
0.21
3.1
3.2
1302.11
1517.86
ng/l
0.22
47
467
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
6
48
1.26
0.20
1.2
1.5
—
—
—
0
0
92
960
0.92
0.19
4.3
5.3
6.98
6.64
mmol/l
0.66
92
905
55
515
1.09
0.19
4.2
4.2
17.93
9.45
mg/mmol
0.37
31
341
107
1031
1.08
0.19
3.1
3.3
38.18
46.66
u/l
1.28
101
974
8
72
1.12
0.16
1.9
2.0
0.11
0.35
g/l
—
8
62
18
159
1.15
0.15
2.8
2.6
33.00
30.16
u/l
0.13
13
129
9
78
1.16
0.15
1.8
1.8
2.49
3.18
g/l
—
9
70
88
849
1.07
0.14
4.1
3.9
0.00
0.01
estimate
0.50
29
188
30
279
1.09
0.12
1.3
1.3
0.72
13.93
u/ml
—
10
108
14
124
1.14
0.11
1.7
1.6
—
—
—
0
0
12
105
1.15
0.11
2.5
1.8
—
—
—
0
0
32
300
1.08
0.11
1.3
1.3
13.92
40.40
iu/ml
—
9
88
5
44
1.14
0.10
1.8
1.3
—
—
—
0
0
28
263
1.08
0.09
1.6
1.5
—
—
—
0
0
5
62
0.80
0.08
1.0
1.8
—
—
—
0
0
5
65
0.76
0.08
1.0
1.9
—
—
—
0
0
7
65
1.08
0.08
2.0
2.0
0.00
0.00
g/l
—
7
59
6
73
0.82
0.07
3.2
1.7
2.47
4.75
ug/l
—
6
64
6
75
0.79
0.07
1.2
2.3
40.67
42.68
u/l
—
6
62
13
143
0.90
0.07
3.5
2.1
2.78
5.20
ug/l
1.23
13
127
9
83
1.09
0.07
1.8
1.8
4.03
4.20
g/l
—
9
75
9
83
1.09
0.07
1.8
1.8
6.53
7.62
g/l
—
9
75
51
525
0.96
0.05
4.2
3.1
26.78
32.42
u/l
1.23
45
497
88
864
1.03
0.05
4.1
3.9
0.00
8.29
estimate
0.50
29
196
11
100
1.11
0.05
1.5
2.5
0.59
0.62
%
0.11
11
100
37
383
0.96
0.05
3.7
4.1
1.02
1.02
kg/l
0.03
26
249
10
91
1.10
0.04
1.2
1.3
—
—
—
0
0
11
102
1.08
0.03
1.5
2.5
0.71
1.19
%
2.79
11
102
59
600
0.98
0.02
2.2
2.0
1.31
1.33
mmol/l
0.07
44
507
67
660
1.02
0.02
3.8
3.8
0.00
0.04
estimate
0.96
22
158
88
871
1.02
0.02
4.2
4.0
0.00
0.00
estimate
-0.00
29
180
15
146
1.03
0.00
1.4
2.4
0.21
0.21
g/l
0.01
15
132
10
103
0.97
0.00
4.8
7.6
25.69
24.98
mmol/l
—
10
103
22
225
0.98
0.00
3.0
6.2
1.02
1.09
mmol/l
0.35
17
205
0
8
0.00
0.00
0.0
1.6
—
1162.75
—
0
8
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
96.25
—
0
8
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
1594.50
—
0
6
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
5.0
—
10.44
—
0
9
0
9
0.00
0.00
0.0
2.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
31.36
—
0
9
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.6
—
9.56
—
0
9
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
1.27
—
0
6
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
5.0
—
4.56
—
0
9
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
59
0.84
-0.00
1.8
1.9
16.37
2.40
mg/l
—
5
47
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
51
0.98
-0.00
1.4
2.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
1.16
—
0
5
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
9.99
—
0
7
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
21
210
1.00
-0.00
4.4
9.2
11.05
11.42
kpa
0.16
21
204
21
210
1.00
-0.00
4.4
9.2
5.20
5.13
kpa
0.15
21
202
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
7
74
0.94
-0.00
2.0
1.9
8.89
10.50
g/l
—
7
65
Mortality – FinRegistry
↥Association
Association between endpoint H8_INNERNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_INNERNAS | 0.994 [0.83, 1.19] | 0.949 |
| Birth year | 0.992 [0.98, 1.0] | 0.078 |
During the follow-up period (1.1.1998 — 31.12.2019), 195 out of 647 females with H8_INNERNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_INNERNAS | 0.865 [0.72, 1.03] | 0.111 |
| Birth year | 0.984 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 211 out of 621 males with H8_INNERNAS died.
Mortality risk
Mortality risk for people of age
years, who have H8_INNERNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.068% | 0.162% |
| 5 | 0.537% | 0.875% |
| 10 | 1.345% | 2.277% |
| 15 | 2.663% | 4.493% |
| 20 | 4.46% | 7.531% |
Relationships between endpoints
↥Index endpoint: H8_INNERNAS – Other specified/unspecified diseases of inner ear
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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