cholesteatoma of external ear: A cholesteatoma which involves invasion of the squamous tissue into a localized area of bony erosion of the ear canal. It may develop spontaneously or as a consequence of infection, trauma or surgery.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
314 |
4. Check minimum number of eventsNone |
314 |
5. Include endpointsNone |
314 |
6. Filter based on genotype QC (FinnGen only) |
277 |
Control definitions (FinnGen only)
- Control exclude
- H8_EXTERNAL
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H60
- Name in latin
- Cholesteatoma meatus acustici externi
Similar endpoints
↥List of similar endpoints to
Cholesteatoma of external ear
based on the number of shared cases.
Similar with more cases:
- Otitis externa
- Diseases of external ear
- Diseases of the ear and mastoid process
- Any operation in hilmo
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2037 | 1011 | 1016 |
| Only index persons | 1930 | 964 | 966 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.03 | 0.03 |
| Only index persons | 0.04 | 0.04 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 64.36 | 65.08 | 63.74 |
| Only index persons | 63.84 | 64.05 | 63.64 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 277 | 120 | 157 |
| Unadjusted period prevalence (%) | 0.06 | 0.04 | 0.07 |
| Median age at first event (years) | 66.82 | 65.26 | 68.01 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 291
- Matched controls
- 2910
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H60.4
ICD-10 Finland
Cholesteatoma of external ear
+∞
307.7
291
*
H71
ICD-10 Finland
Cholesteatoma of middle ear
100.7
143.1
75
10
UDC00
NOMESCO Finland
Ear microscopy
15.4
110.0
120
127
DC1AD
NOMESCO Finland
Temporalbone CT
70.6
103.2
57
10
H60.9
ICD-10 Finland
Otitis externa, unspecified
13.5
75.3
81
81
H60.8
ICD-10 Finland
Other otitis externa
21.8
55.5
43
23
H72.0
ICD-10 Finland
Central perforation of tympanic membrane
19.0
53.2
44
27
DFF00
NOMESCO Finland
Pure tone audiometry
7.0
49.7
97
195
H60.3
ICD-10 Finland
Other infective otitis externa
21.5
46.5
36
19
H66.0
ICD-10 Finland
Acute suppurative otitis media
8.9
42.4
59
81
H61.2
ICD-10 Finland
Impacted cerumen
8.8
41.4
58
80
DBD20
NOMESCO Finland
Plastic repair of external auditory canal
162.9
40.9
42
*
Z01.1
ICD-10 Finland
Examination of ears and hearing
5.1
35.3
99
269
H66.9
ICD-10 Finland
Otitis media, unspecified
8.4
31.9
45
62
H61.8
ICD-10 Finland
Other specified disorders of external ear
119.4
30.3
32
*
TDW99
NOMESCO Finland
Other minor procedure in surgery of ear, nose and larynx
10.3
28.8
34
37
TDA90
NOMESCO Finland
Removal wax from ear
34.0
28.0
36
12
DBB00
NOMESCO Finland
Excision of lesion of external auditory canal
+∞
22.2
21
*
H01
ICPC
Ear pain/earache
4.3
19.5
57
155
H65.3
ICD-10 Finland
Chronic mucoid otitis media
16.6
18.9
30
20
H04
ICPC
Ear discharge
7.0
18.3
29
45
H90.6
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, bilateral
18.1
18.3
28
17
H66.4
ICD-10 Finland
Suppurative otitis media, unspecified
35.5
18.3
23
7
R5120
NOMESCO Finland
Preparation of an aid
6.6
17.2
29
48
DCD00
NOMESCO Finland
Myringoplasty
23.6
17.2
24
11
DFF15
NOMESCO Finland
Speech audiometry
4.7
15.8
39
92
H13
ICPC
Plugged feeling ear
3.0
15.6
94
403
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
3.0
15.5
90
378
H60
ICD-10 Finland
Otitis externa
5.3
15.1
32
66
DEA10
NOMESCO Finland
Attico-antrotomy
+∞
14.7
14
*
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
12.9
14.4
25
21
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
2.8
13.8
87
380
H70
ICPC
Otitis externa
13.8
13.7
23
18
H92.0
ICD-10 Finland
Otalgia
4.9
13.4
31
69
H66.3
ICD-10 Finland
Other chronic suppurative otitis media
73.1
12.7
14
*
H65.2
ICD-10 Finland
Chronic serous otitis media
18.4
12.7
19
11
DBD10
NOMESCO Finland
Reconstruction of external auditory canal
+∞
12.6
12
*
UDH02
NOMESCO Finland
Rhinopharyngoscopy
4.1
12.4
37
101
H90.4
ICD-10 Finland
Sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
4.9
12.2
28
62
DAX00
NOMESCO Finland
Adjustment or review of hearing aid
3.9
11.6
37
106
H70.1
ICD-10 Finland
Chronic mastoiditis
124.7
11.5
12
*
DCD10
NOMESCO Finland
Tympanoplasty
62.3
10.7
12
*
DCA10
NOMESCO Finland
Paracentesis of tympanic membrane
12.7
10.5
18
15
ZXA05
NOMESCO Finland
Left side
2.4
10.4
96
496
S02CA02
ATC
flumetasone and antiinfectives; otic
4.1
10.3
30
80
H72.2
ICD-10 Finland
Other marginal perforations of tympanic membrane
20.9
9.9
14
7
H81
ICPC
Excessive ear wax
2.5
9.8
76
362
H90.1
ICD-10 Finland
Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side
18.3
9.5
14
8
DAX08
NOMESCO Finland
Fitting of hearing aid
3.4
9.4
36
116
DBB02
NOMESCO Finland
Excision of a neoplasm from external auditory canal
+∞
9.4
9
*
H29
ICPC
Ear symptom/complaint other
2.7
8.8
51
209
38700
ICD-8 Finland
Other disease of ear and mastoid process, Cholesteatoma of ear
51.6
8.7
10
*
S18
ICPC
Laceration/cut
2.1
8.5
161
1088
DEB25
NOMESCO Finland
Attico-antro-mastoidectomy and tympanoplasty
92.6
8.5
9
*
H74.1
ICD-10 Finland
Adhesive middle ear disease
92.6
8.5
9
*
DBW99
NOMESCO Finland
Other operation on external auditory canal
+∞
8.4
8
*
DFF30
NOMESCO Finland
Loudness discomfort Level (LDL)
4.4
8.3
21
50
Z97.4
ICD-10 Finland
Presence of external hearing-aid
3.3
8.3
32
104
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
2.6
8.1
54
237
SPAT1260
SPAT
Consultation of another employee
2.4
8.0
63
299
Z46.1
ICD-10 Finland
Fitting and adjustment of hearing aid
3.0
8.0
37
134
H61.9
ICD-10 Finland
Disorder of external ear, unspecified
46.2
7.8
9
*
S03CA04
ATC
hydrocortisone and antiinfectives; ophthalmic, otic
7.0
7.7
18
27
WX408
NOMESCO Finland
General anesthesy, balanced
2.1
7.6
90
506
R5130
NOMESCO Finland
Repair work or maintenance done on the aid
4.0
7.5
22
59
J01DB01
ATC
cefalexin; oral
2.5
7.4
246
2006
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.5
7.3
51
229
H60.5
ICD-10 Finland
Acute otitis externa, noninfective
16.3
7.3
11
7
WX704
NOMESCO Finland
Intubation
3.0
7.1
32
114
J01MA02
ATC
ciprofloxacin; systemic
1.9
7.0
128
836
H65.0
ICD-10 Finland
Acute serous otitis media
9.7
6.9
13
14
R03BB04
ATC
tiotropium bromide; inhalant
2.6
6.8
44
190
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.9
6.8
127
834
S03CA01
ATC
dexamethasone and antiinfectives; ophthalmic, otic
7.7
6.5
14
19
WX110
NOMESCO Finland
Infiltration anesthesia
2.0
6.5
207
1613
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
4.0
6.4
18
47
D23.2
ICD-10 Finland
Benign neoplasm: Skin of ear and external auricular canal
9.6
6.3
12
13
H65.9
ICD-10 Finland
Nonsuppurative otitis media, unspecified
18.5
6.3
9
5
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.9
6.3
160
1153
R02
ICPC
Shortness of breath/dyspnoea
2.3
6.1
49
234
H68.1
ICD-10 Finland
Obstruction of Eustachian tube
10.3
6.1
11
11
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
240
1946
2.33
7.14
10.6
9.0
81.63
81.06
u/l
0.06
227
1844
162
1183
1.83
5.99
3.3
2.9
—
—
estimate
—
0
0
64
349
2.07
5.71
5.5
8.2
1.92
0.78
mmol/l
1.36
55
292
189
1468
1.82
5.50
11.3
10.6
4.45
4.21
e9/l
0.72
171
1288
270
2394
2.77
5.16
29.4
18.1
29.25
25.11
mg/l
1.09
243
2010
93
599
1.81
5.01
2.0
1.8
1.10
1.49
mg/l
1.22
77
482
222
1842
1.87
4.87
6.3
4.6
14.94
12.81
mm/h
1.19
209
1716
171
1318
1.72
4.83
26.6
14.7
1.31
1.27
inr
0.35
151
1097
121
859
1.70
4.55
2.3
2.2
197.74
220.30
u/l
0.16
113
814
170
1328
1.67
4.39
3.1
2.7
—
—
—
0
0
193
1584
1.65
3.89
6.0
5.3
6.66
6.80
mmol/l
0.49
181
1503
170
1353
1.62
3.88
5.3
4.1
0.00
0.00
estimate
-0.00
33
294
75
485
1.74
3.87
2.4
2.0
—
—
—
0
0
171
1367
1.61
3.80
5.4
4.2
0.00
5.43
estimate
0.50
33
299
100
705
1.64
3.72
2.3
2.3
2.50
3.02
mg/l
1.62
86
618
170
1362
1.60
3.70
10.2
7.6
1.19
1.21
mmol/l
1.66
146
1171
43
238
1.95
3.64
2.3
2.6
6.97
7.48
ug/l
0.06
38
213
19
74
2.68
3.63
2.2
1.5
—
—
—
0
0
80
536
1.68
3.61
4.9
4.1
366.80
349.46
ng/l
0.02
63
457
145
1124
1.58
3.60
2.5
2.5
81.12
77.51
nmol/l
0.74
135
1007
176
1429
1.59
3.56
7.6
7.4
9.46
12.07
umol/l
5.97
171
1367
9
17
5.43
3.54
1.1
1.3
306.11
95.88
pmol/l
—
9
17
171
1382
1.58
3.51
5.3
4.2
0.00
1.10
estimate
0.50
29
272
135
1045
1.54
3.28
5.5
4.1
0.00
0.03
estimate
1.13
30
255
58
367
1.72
3.20
2.4
1.8
—
—
—
0
0
248
2219
1.80
3.17
5.8
5.2
2.24
1.99
mu/l
1.48
230
2034
5
5
10.14
2.99
1.0
1.2
81.20
105.40
%
—
5
5
67
450
1.64
2.95
1.9
2.2
29.16
29.44
s
0.23
62
438
47
290
1.74
2.83
9.2
8.5
—
—
—
0
0
53
339
1.69
2.81
2.4
1.9
—
—
—
0
0
144
1160
1.48
2.75
2.3
2.2
93.44
96.26
pmol/l
0.26
89
614
84
605
1.55
2.74
6.2
4.4
1.02
1.02
kg/l
0.13
57
414
152
1241
1.47
2.69
8.7
6.9
1.19
1.21
mmol/l
2.37
145
1137
272
2535
2.12
2.65
34.4
24.1
89.45
81.37
umol/l
0.75
272
2513
270
2510
2.05
2.64
16.4
13.2
23.71
26.23
u/l
1.98
264
2446
141
1138
1.46
2.63
3.4
3.1
124.65
145.49
ug/l
0.58
131
1058
37
218
1.80
2.60
1.6
1.5
—
—
—
0
0
11
36
3.13
2.59
11.8
3.6
9.43
6.55
mmol/l
—
6
29
86
631
1.52
2.56
2.5
2.5
—
—
—
0
0
138
1113
1.46
2.56
4.8
4.2
26.72
42.93
ng/l
1.93
110
852
6
11
5.54
2.55
1.3
1.7
87.83
81.55
umol/l
—
6
11
274
2577
2.08
2.32
40.8
27.3
91.76
91.57
fl
0.25
274
2554
274
2577
2.08
2.32
40.9
27.3
246.49
242.71
e9/l
0.44
274
2531
274
2578
2.08
2.30
41.5
27.9
39.56
40.20
%
1.36
274
2553
274
2578
2.08
2.30
40.9
27.3
4.37
4.46
e12/l
1.94
274
2525
114
901
1.44
2.30
4.3
3.5
2.33
2.35
mmol/l
0.77
104
815
274
2579
2.07
2.28
41.2
27.5
131.41
134.77
g/l
3.26
274
2554
28
158
1.85
2.27
1.9
1.3
—
—
—
0
0
261
2421
1.76
2.27
6.2
6.2
2.52
2.61
mmol/l
0.89
245
2245
208
1836
1.47
2.26
4.8
4.1
14.59
14.95
pmol/l
1.29
193
1666
251
2309
1.63
2.20
22.8
17.9
77.86
77.29
ml/min/173m2
0.16
240
2165
255
2356
1.67
2.18
5.4
5.4
5.99
6.05
mmol/l
0.27
234
2172
21
109
2.00
2.16
3.6
3.2
—
—
—
0
0
7
19
3.75
2.16
4.6
4.7
14.49
103.83
u/ml
—
7
19
6
14
4.35
2.16
1.0
2.2
—
—
—
0
0
18
89
2.09
2.11
1.1
1.6
—
—
—
0
0
5
10
5.07
2.08
1.0
1.0
1546.80
1258.80
miu/ml
—
5
10
14
63
2.28
2.04
1.1
1.5
—
—
—
0
0
117
950
1.39
1.96
3.3
3.5
1179.99
1520.06
ng/l
0.58
105
822
5
11
4.60
1.95
1.6
2.0
14.48
13.36
%
—
5
11
103
821
1.39
1.92
1.7
1.8
19.60
20.65
nmol/l
0.22
91
700
256
2384
1.61
1.91
5.7
5.5
4.43
4.50
mmol/l
0.60
240
2212
33
211
1.64
1.77
1.6
1.6
—
—
—
0
0
254
2372
1.56
1.75
5.5
5.3
1.44
1.44
mmol/l
0.06
236
2192
64
476
1.44
1.74
1.7
1.8
1240.27
1249.58
nmol/l
0.03
46
361
7
24
2.96
1.73
1.1
1.3
—
—
—
0
0
15
75
2.05
1.73
1.1
1.5
—
—
—
0
0
7
26
2.73
1.59
1.1
1.1
—
—
—
0
0
106
878
1.33
1.49
5.0
4.9
21.30
21.54
%
0.06
60
451
96
788
1.33
1.43
4.0
3.2
0.29
0.52
e6/l
0.86
75
571
28
183
1.59
1.41
3.5
3.5
1.51
1.82
mmol/l
0.24
22
136
246
2315
1.41
1.29
7.6
7.1
40.48
40.06
mmol/mol
0.27
231
2170
94
781
1.30
1.27
6.3
4.2
0.00
0.01
estimate
0.50
31
267
15
85
1.81
1.25
1.1
1.5
—
—
—
0
0
12
63
1.94
1.24
2.3
1.6
11905.29
11878.44
e6/l
—
7
50
8
38
2.14
1.19
1.0
1.2
—
—
—
0
0
5
20
2.53
1.15
5.8
2.2
—
—
—
0
0
7
30
2.37
1.13
6.6
2.5
—
—
—
0
0
8
41
1.98
1.09
1.0
1.7
—
—
—
0
0
7
32
2.22
1.09
1.0
1.8
—
—
—
0
0
7
32
2.22
1.09
1.0
1.8
—
—
—
0
0
7
32
2.22
1.09
1.0
1.8
—
—
—
0
0
177
1617
1.24
1.01
4.2
3.6
50.37
52.71
u/l
0.17
163
1522
22
150
1.50
0.96
1.7
1.2
817.03
320.26
u/ml
0.52
22
138
82
696
1.25
0.91
3.0
3.1
349.14
359.00
umol/l
0.34
70
614
88
756
1.24
0.88
5.0
3.6
0.00
0.11
estimate
0.55
31
237
68
570
1.25
0.84
1.3
1.3
1.75
1.54
u/ml
0.07
13
168
39
305
1.32
0.82
3.9
4.6
6.56
49.34
ug/l
0.99
34
266
11
66
1.69
0.80
2.0
1.3
—
—
—
0
0
11
67
1.67
0.76
1.2
1.5
—
—
—
0
0
36
282
1.32
0.76
3.9
3.6
—
—
—
0
0
75
645
1.22
0.74
3.7
3.3
0.67
0.76
ug/l
0.44
59
433
14
92
1.55
0.73
2.4
1.8
—
—
—
0
0
9
58
1.57
0.70
1.0
1.8
—
—
—
0
0
122
1103
1.18
0.70
6.0
5.8
1.90
2.74
ug/l
1.14
114
995
15
102
1.50
0.69
2.4
1.9
—
—
—
0
0
238
2283
1.23
0.68
4.8
4.6
1.28
1.28
mmol/l
0.06
218
2099
68
585
1.21
0.67
1.7
1.9
247273177.16
8213988.64
pmol/l
0.75
55
487
7
44
1.61
0.65
1.0
1.4
—
—
—
0
0
28
219
1.31
0.61
3.3
2.9
75.15
60.99
ml/min/173m2
0.98
13
99
38
310
1.26
0.61
6.1
3.7
6.09
5.69
kpa
2.62
38
302
0
20
0.00
0.60
0.0
1.4
—
—
—
0
0
14
97
1.47
0.60
1.5
1.3
—
—
—
0
0
9
60
1.52
0.55
5.1
2.7
8.44
7.59
pmol/l
—
9
60
6
39
1.55
0.53
1.0
1.4
—
—
—
0
0
9
133
0.67
0.53
3.8
3.7
74.22
2073.72
u/ml
—
9
109
33
271
1.25
0.51
4.8
3.0
4.28
4.41
kpa
0.15
33
262
57
497
1.18
0.50
3.4
2.7
11.62
12.49
umol/l
0.29
51
460
54
470
1.18
0.48
3.4
2.6
2.23
2.26
g/l
0.12
47
432
12
86
1.41
0.45
1.5
1.4
—
—
—
0
0
5
32
1.57
0.42
7.2
3.2
28.40
8.32
nmol/l
—
5
32
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
5
34
1.48
0.40
1.0
2.2
—
—
—
0
0
22
178
1.26
0.40
2.2
1.7
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
5
35
1.44
0.39
1.6
1.5
—
—
—
0
0
5
35
1.44
0.39
1.6
1.5
—
—
—
0
0
5
35
1.44
0.39
1.6
1.5
—
—
—
0
0
5
36
1.40
0.38
1.0
2.2
—
—
—
0
0
110
1026
1.12
0.37
2.1
2.0
1.73
1.32
mmol/l
0.64
94
851
5
78
0.63
0.36
1.4
1.5
—
—
—
0
0
10
73
1.38
0.35
3.8
3.6
0.40
1.94
index
—
5
47
10
74
1.36
0.32
1.7
1.3
—
—
—
0
0
21
174
1.22
0.32
5.8
4.1
44.85
47.62
%
0.23
21
169
49
439
1.14
0.32
3.6
2.6
20.21
21.81
%
0.37
43
409
45
402
1.14
0.31
1.3
1.3
1.23
11.87
u/ml
1.97
18
143
7
54
1.30
0.30
1.1
1.2
1.37
1.55
g/l
—
7
54
7
55
1.28
0.30
1.1
1.5
—
—
—
0
0
17
139
1.24
0.29
1.5
1.8
—
—
—
0
0
7
57
1.23
0.29
1.1
1.2
0.81
0.89
g/l
—
7
57
8
64
1.26
0.27
1.1
1.5
—
—
—
0
0
39
349
1.14
0.27
1.8
1.5
—
—
—
0
0
13
105
1.25
0.25
2.7
1.8
6.00
5.04
iu/ml
—
7
27
48
438
1.11
0.24
1.4
1.3
13.96
38.65
iu/ml
3.67
17
134
6
84
0.71
0.24
1.0
1.7
—
—
—
0
0
5
38
1.32
0.23
4.0
3.8
16.80
35.74
u/ml
—
5
38
18
153
1.19
0.23
1.6
1.9
—
—
—
0
0
5
39
1.29
0.23
1.0
1.3
—
—
—
0
0
36
325
1.12
0.22
5.3
5.3
32.86
31.47
%
0.29
22
221
41
449
0.90
0.22
3.9
3.1
1.18
2.17
e6/l
0.91
17
225
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
41.89
—
0
10
0
12
0.00
0.21
0.0
1.8
—
60.30
—
0
12
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
6
52
1.16
0.19
1.3
1.3
3.40
3.84
mmol/l
—
6
46
29
262
1.12
0.18
1.9
1.5
—
—
—
0
0
7
63
1.11
0.17
1.0
1.2
—
—
—
0
0
8
72
1.11
0.16
2.0
2.2
—
—
—
0
0
18
200
0.89
0.13
6.9
3.4
130.89
129.07
g/l
0.14
18
195
97
940
1.05
0.11
4.5
4.1
12.14
8.94
mg/mmol
0.29
67
600
5
46
1.09
0.09
1.0
3.8
—
4606.17
—
0
6
5
48
1.04
0.09
1.2
1.8
—
—
—
0
0
5
48
1.04
0.09
1.2
1.3
—
—
—
0
0
16
175
0.91
0.08
3.6
2.7
1.32
1.22
%
0.14
16
175
6
58
1.04
0.08
1.8
2.2
—
—
—
0
0
6
72
0.83
0.07
1.7
1.9
175.33
233.52
pmol/l
—
6
66
9
105
0.85
0.06
1.0
1.0
—
—
—
0
0
16
171
0.93
0.05
3.6
2.7
0.69
0.63
%
0.43
16
171
16
150
1.07
0.04
8.9
3.6
25.75
24.71
mmol/l
0.76
16
145
50
487
1.03
0.04
3.5
3.0
0.72
1.06
e6/l
0.58
25
257
11
103
1.07
0.02
3.3
3.6
44.25
115.99
mg/l
0.65
11
88
11
103
1.07
0.02
3.3
3.6
68.06
33.13
mg/l
0.37
11
89
12
118
1.02
0.00
1.2
1.3
—
—
—
0
0
15
147
1.02
0.00
4.7
4.2
1.01
1.02
ratio
1.84
15
142
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
9.7
—
5.80
—
0
6
0
6
0.00
0.00
0.0
1.2
—
17.40
—
0
6
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
7
76
0.92
0.00
1.6
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
9
0.00
0.00
0.0
2.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
10.11
—
0
9
0
9
0.00
0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
8.27
—
0
8
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
6
59
1.02
-0.00
1.2
1.1
—
2.39
—
0
10
7
71
0.99
-0.00
1.1
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
11.2
—
10.98
—
0
5
5
59
0.84
-0.00
1.2
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
5
59
0.84
-0.00
1.2
1.2
—
—
—
0
0
7
71
0.99
-0.00
1.1
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H8_EXT_CHOL and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_EXT_CHOL | 1.283 [1.02, 1.62] | 0.035 |
| Birth year | 0.998 [0.99, 1.01] | 0.613 |
During the follow-up period (1.1.1998 — 31.12.2019), 222 out of 870 females with H8_EXT_CHOL died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_EXT_CHOL | 1.268 [1.01, 1.6] | 0.043 |
| Birth year | 0.99 [0.98, 1.0] | 0.031 |
During the follow-up period (1.1.1998 — 31.12.2019), 225 out of 883 males with H8_EXT_CHOL died.
Mortality risk
Mortality risk for people of age
years, who have H8_EXT_CHOL.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.122% | 0.26% |
| 5 | 0.774% | 1.499% |
| 10 | 2.0% | 3.783% |
| 15 | 3.865% | 7.259% |
| 20 | 6.95% | 12.422% |
Relationships between endpoints
↥Index endpoint: H8_EXT_CHOL – Cholesteatoma of external ear
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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