eyelid disease: A disease involving the eyelid.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
359 |
4. Check minimum number of eventsNone |
359 |
5. Include endpointsNone |
359 |
6. Filter based on genotype QC (FinnGen only) |
315 |
Control definitions (FinnGen only)
- Control exclude
- H7_LIDLACRIMALORBIT
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H02
- Name in latin
- Xanthelasma palpebrae
Similar endpoints
↥List of similar endpoints to
Xanthelasma of eyelid
based on the number of shared cases.
Similar with more cases:
- Other disorders of eyelid
- Disorders of eyelid, lacrimal system and orbit
- Diseases of the eye and adnexa
- Any prescribed medicine buy
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2377 | 1690 | 683 |
| Only index persons | 2263 | 1624 | 639 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.05 | 0.02 |
| Only index persons | 0.05 | 0.06 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 53.93 | 54.29 | 52.96 |
| Only index persons | 53.67 | 54.08 | 52.62 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 315 | 214 | 101 |
| Unadjusted period prevalence (%) | 0.07 | 0.08 | 0.05 |
| Median age at first event (years) | 54.22 | 54.00 | 54.70 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 325
- Matched controls
- 3250
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H02.6
ICD-10 Finland
Xanthelasma of eyelid
+∞
307.7
325
*
CBB30
NOMESCO Finland
Excision of lesion of eyelid
36.5
156.4
105
42
H02.3
ICD-10 Finland
Blepharochalasis
48.5
77.5
46
11
CBB99
NOMESCO Finland
Other excision or destruction of lesion of eyelid
91.6
30.4
33
*
ZXC10
NOMESCO Finland
Use of laser
8.2
20.3
28
37
QAA40
NOMESCO Finland
Laser therapy or photocoagulation of skin of head or neck
70.7
17.9
20
*
CBB10
NOMESCO Finland
Excision of redundant skin of eyelid
+∞
17.9
17
*
CBB11
NOMESCO Finland
Resection of lax skin in upper eyelid
+∞
16.8
16
*
H02.4
ICD-10 Finland
Ptosis of eyelid
40.2
15.6
19
5
CBB20
NOMESCO Finland
Correction of lax skin of eyelid and resection of herniated fat
+∞
13.6
13
*
ZXA10
NOMESCO Finland
Bilateral
2.6
11.3
81
371
SPAT1153
SPAT
Removal of sutures
2.2
10.3
126
725
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
2.4
10.0
83
404
D23.1
ICD-10 Finland
Benign neoplasm: Skin of eyelid, including canthus
4.5
9.8
24
56
QAA25
NOMESCO Finland
Destruction of lesion of head or neck
7.7
9.4
21
29
TPH04
NOMESCO Finland
Cathetrisation of vein
2.3
9.3
91
475
H04.10
ICD-10 Finland
Dry eye syndrome
3.2
9.0
38
130
WX110
NOMESCO Finland
Infiltration anesthesia
2.2
8.8
244
1874
H02.1
ICD-10 Finland
Ectropion of eyelid
+∞
8.4
8
*
H02.0
ICD-10 Finland
Entropion and trichiasis of eyelid
+∞
8.4
8
*
J45.9
ICD-10 Finland
Asthma, unspecified
2.2
7.6
79
420
XQ848
NOMESCO Finland
Dermatological photography
4.5
7.3
18
42
C10AA01
ATC
simvastatin; oral
1.9
7.2
146
980
N07BA03
ATC
varenicline; oral
3.6
7.1
24
71
E78.00
ICD-10 Finland
Familial hypercholesterolaemia
3.9
7.0
21
57
C10AA07
ATC
rosuvastatin; oral
1.9
6.9
135
891
N02AX02
ATC
tramadol; systemic, rectal
1.9
6.9
156
1081
C10AA05
ATC
atorvastatin; oral
1.8
6.8
158
1100
QAA50
NOMESCO Finland
Cryotherapy of skin of head or neck
11.3
6.3
11
10
ZXC07
NOMESCO Finland
Carbon dioxide laser
+∞
6.3
6
*
R03AK06
ATC
salmeterol and fluticasone; inhalant
2.2
6.2
58
294
J01AA02
ATC
doxycycline; systemic
2.1
6.1
267
2237
C10AX09
ATC
ezetimibe; oral
2.0
6.0
71
393
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
142
1005
1.73
5.46
4.2
4.0
6.53
7.92
mg/mmol
0.19
89
623
141
1021
1.67
4.83
3.3
3.2
7.40
7.21
mmol/l
0.19
122
863
256
2193
1.79
4.41
5.2
4.5
14.62
12.63
mm/h
1.30
247
2055
176
1397
1.57
3.86
12.5
12.7
1.20
1.22
inr
0.13
146
1159
129
957
1.58
3.78
2.9
2.4
57.87
62.38
u/l
0.22
120
888
207
1721
1.56
3.57
5.1
4.6
6.87
6.63
mmol/l
1.00
194
1637
258
2285
1.63
3.14
9.0
8.2
84.56
79.57
u/l
0.45
251
2162
300
2778
2.04
3.03
20.9
15.7
20.73
23.16
mg/l
0.89
269
2300
132
1032
1.47
2.84
3.7
3.3
30.06
29.95
u/l
0.02
127
972
161
1321
1.43
2.63
5.9
4.4
35.69
35.68
g/l
0.01
155
1250
187
1584
1.43
2.52
4.5
3.9
0.00
0.03
estimate
1.06
39
313
185
1567
1.42
2.48
4.5
3.9
0.00
5.56
estimate
0.50
38
338
293
2724
1.77
2.46
8.2
6.6
40.67
39.40
mmol/mol
1.73
279
2561
182
1539
1.41
2.45
8.4
6.7
1.21
1.22
mmol/l
0.20
160
1332
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
6
12
5.07
2.41
1.0
1.1
134.17
106.92
%
—
6
12
196
1682
1.42
2.41
9.4
10.2
4.54
4.05
e9/l
2.31
182
1476
159
1321
1.40
2.33
2.5
2.1
99.85
98.37
pmol/l
0.14
92
669
182
1551
1.39
2.28
4.5
3.9
0.00
0.00
estimate
0.50
36
325
66
468
1.51
2.25
2.3
1.9
—
—
—
0
0
139
1137
1.39
2.20
4.0
3.9
38.03
83.99
ng/l
0.44
101
838
251
2271
1.46
2.17
5.5
4.5
14.88
14.86
pmol/l
0.04
239
2082
6
14
4.34
2.16
1.0
1.0
110.00
110.50
%
—
6
14
16
75
2.19
2.12
1.3
1.6
3.08
3.81
iu/l
—
6
26
215
1909
1.37
1.95
5.3
4.6
222.33
230.68
e6/l
—
6
34
9
34
2.69
1.88
2.3
1.5
—
—
—
0
0
115
934
1.36
1.84
2.8
3.3
1066.87
1388.94
ng/l
0.65
100
805
15
73
2.11
1.83
1.2
1.2
—
—
—
0
0
25
147
1.76
1.80
9.3
8.8
15.22
15.52
%
0.17
25
140
283
2652
1.52
1.76
6.9
5.5
1.87
1.93
mu/l
0.33
266
2445
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
5
13
3.89
1.72
1.2
1.0
193.60
141.69
%
—
5
13
159
1368
1.32
1.69
3.0
2.6
—
—
estimate
—
0
0
292
2762
1.56
1.65
6.6
5.4
6.19
5.97
mmol/l
1.96
275
2557
11
49
2.29
1.65
4.8
3.8
0.92
0.79
nmol/l
0.51
11
41
36
243
1.54
1.55
1.7
1.5
—
—
—
0
0
156
1350
1.30
1.55
2.8
2.5
76.93
77.87
nmol/l
0.17
147
1223
49
354
1.45
1.54
2.3
1.8
—
—
—
0
0
104
857
1.31
1.47
4.0
3.4
1.76
0.02
estimate
0.49
29
263
58
437
1.40
1.45
1.6
1.4
—
—
—
0
0
45
327
1.44
1.38
6.8
7.6
0.30
1.05
mmol/l
0.66
40
273
10
47
2.16
1.35
1.6
1.1
—
—
—
0
0
10
47
2.16
1.35
1.6
1.1
—
—
—
0
0
84
683
1.31
1.29
4.8
4.0
1.02
1.02
kg/l
0.26
58
462
45
332
1.41
1.28
2.4
1.9
—
—
—
0
0
178
1593
1.26
1.26
3.1
2.8
—
—
—
0
0
6
25
2.43
1.25
3.0
3.1
2.22
3.07
nmol/l
—
6
25
64
503
1.34
1.24
1.7
1.7
933.28
1269.97
nmol/l
2.21
50
383
24
156
1.58
1.24
1.2
1.3
—
40.87
—
0
10
8
39
2.08
1.16
1.9
2.0
12.75
10.31
mmol/l
—
8
39
298
2867
1.47
1.13
7.5
6.1
2.85
2.74
mmol/l
1.10
284
2660
8
40
2.02
1.13
2.8
2.5
1.21
1.18
mmol/l
—
8
40
8
40
2.02
1.13
2.8
2.5
106.13
105.97
mmol/l
—
8
40
88
734
1.27
1.11
2.6
2.1
2.84
3.04
mg/l
0.36
77
636
294
2823
1.43
1.11
6.5
5.4
4.77
4.72
mmol/l
0.30
280
2629
135
1184
1.24
1.10
4.6
3.8
0.10
0.02
estimate
0.35
31
276
11
59
1.89
1.08
1.2
1.2
17.45
9.73
u/l
0.69
11
46
68
552
1.29
1.06
4.5
3.9
53.52
416.53
ng/l
2.99
50
430
67
549
1.28
0.98
4.6
4.6
24.03
21.66
%
0.61
40
268
21
141
1.52
0.97
6.6
4.7
1.43
1.56
%
0.46
21
130
153
1379
1.21
0.92
7.3
5.8
1.21
1.22
mmol/l
0.45
142
1278
81
685
1.24
0.91
1.8
1.6
0.88
1.31
mg/l
1.54
68
549
91
780
1.23
0.90
2.6
2.7
312.20
339.58
umol/l
1.85
82
685
12
73
1.67
0.82
1.6
1.8
133.17
127.69
g/l
—
6
58
36
278
1.33
0.82
7.9
8.0
118.86
119.27
g/l
0.04
36
271
285
2749
1.30
0.80
19.5
15.3
78.84
79.00
ml/min/173m2
0.05
270
2579
0
25
0.00
0.79
0.0
1.0
—
—
—
0
0
72
612
1.23
0.77
1.4
1.3
26.92
31.42
iu/ml
0.20
20
202
11
67
1.66
0.76
1.3
1.8
—
—
—
0
0
9
54
1.69
0.75
1.6
7.3
—
147.50
—
0
8
118
1055
1.19
0.75
3.7
3.6
2.35
2.36
mmol/l
0.27
113
963
7
38
1.86
0.74
1.0
1.7
—
—
—
0
0
94
826
1.19
0.72
3.9
3.1
0.73
0.43
e6/l
0.51
75
586
140
1275
1.17
0.71
2.0
2.0
1.35
1.35
mmol/l
0.03
124
1068
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
12
77
1.58
0.69
2.3
2.4
0.21
0.39
iu/ml
—
6
46
10
61
1.66
0.69
1.6
1.6
—
—
—
0
0
5
27
1.86
0.68
1.6
2.1
13.22
13.31
%
—
5
27
7
43
1.64
0.67
1.0
1.2
8.54
7.30
mmol/l
—
7
36
13
86
1.53
0.67
1.0
1.4
292.43
292.72
ug/g
—
7
53
35
280
1.28
0.64
3.4
2.4
56.90
32.24
u/l
0.49
30
231
11
71
1.57
0.63
1.3
1.2
—
—
—
0
0
279
2704
1.22
0.60
5.5
4.5
1.33
1.30
mmol/l
0.30
258
2489
204
1930
1.15
0.59
3.7
3.2
67.01
50.13
u/l
0.44
192
1819
0
23
0.00
0.58
0.0
3.5
—
1.39
—
0
23
116
1056
1.15
0.57
4.1
3.2
—
—
—
0
0
13
90
1.46
0.56
3.3
3.3
2.44
1.75
ratio
—
6
57
12
82
1.48
0.55
3.2
3.0
1.70
1.48
mg/l
0.35
12
73
41
343
1.22
0.53
2.0
4.5
2.42
19.92
ug/l
0.82
32
287
6
97
0.61
0.53
1.0
1.4
—
—
—
0
0
22
171
1.31
0.51
1.9
1.7
—
—
—
0
0
74
658
1.16
0.50
1.9
1.7
381.43
20430563.04
pmol/l
0.79
65
558
288
2812
1.21
0.48
6.5
5.3
1.41
1.51
mmol/l
4.04
272
2608
14
102
1.39
0.48
2.0
2.0
—
—
—
0
0
7
48
1.47
0.47
1.3
1.2
—
—
—
0
0
69
616
1.15
0.45
3.3
2.9
2.47
2.46
mmol/l
0.33
61
561
53
464
1.17
0.44
3.4
2.9
2.92
3.18
e6/l
0.10
29
211
62
550
1.16
0.44
1.4
1.3
20.35
11.19
u/ml
0.29
26
221
6
93
0.64
0.43
1.3
1.2
—
—
—
0
0
13
96
1.37
0.42
1.7
2.6
14.75
12.31
mg/l
0.45
13
91
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
15
0.00
0.41
0.0
1.7
—
—
—
0
0
0
16
0.00
0.41
0.0
1.2
—
—
—
0
0
5
34
1.48
0.40
1.6
1.1
—
—
—
0
0
0
19
0.00
0.39
0.0
1.4
—
—
—
0
0
24
197
1.24
0.39
2.2
1.5
—
—
—
0
0
6
41
1.47
0.36
1.0
1.1
—
—
—
0
0
46
406
1.15
0.36
7.3
6.3
105.50
104.16
mmol/l
1.27
46
406
46
407
1.15
0.35
2.8
3.1
0.65
0.81
ug/l
0.85
34
266
6
45
1.34
0.34
2.0
1.6
—
—
—
0
0
56
505
1.13
0.33
3.3
2.8
0.94
1.06
e6/l
0.19
32
250
42
371
1.15
0.33
5.7
5.0
31.21
32.32
%
0.26
33
246
16
128
1.26
0.32
1.6
1.4
—
—
—
0
0
11
83
1.34
0.32
2.0
1.9
—
—
—
0
0
51
458
1.13
0.32
1.6
1.5
—
—
—
0
0
14
175
0.79
0.31
4.0
2.2
1.38
1.20
%
0.22
14
175
77
710
1.11
0.31
3.0
2.3
—
—
—
0
0
7
52
1.35
0.31
1.9
1.6
—
—
—
0
0
7
52
1.35
0.31
1.0
1.6
—
—
—
0
0
13
102
1.29
0.30
1.2
1.6
—
—
—
0
0
10
76
1.33
0.28
1.1
1.3
—
—
—
0
0
21
177
1.20
0.28
7.0
7.6
24.38
24.81
mmol/l
0.26
21
168
12
95
1.27
0.26
2.0
1.8
—
—
—
0
0
9
73
1.24
0.25
1.6
1.3
—
—
—
0
0
5
38
1.32
0.23
1.0
1.1
—
—
—
0
0
94
889
1.08
0.23
1.9
1.7
20.44
20.58
nmol/l
0.04
79
745
12
97
1.25
0.23
1.6
1.5
—
—
—
0
0
17
199
0.85
0.22
6.1
2.5
126.24
129.29
g/l
0.19
17
194
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
2.5
—
—
—
0
0
14
166
0.84
0.21
1.6
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
10
80
1.26
0.20
1.8
1.6
—
—
—
0
0
6
48
1.25
0.20
1.0
1.4
—
—
—
0
0
32
289
1.12
0.20
6.3
2.8
1.62
2.24
mmol/l
0.30
27
255
70
659
1.08
0.19
1.4
1.3
1.21
1.58
u/ml
0.25
18
189
8
68
1.18
0.16
1.0
1.1
—
8.57
—
0
10
8
70
1.15
0.16
1.3
1.1
—
—
—
0
0
11
130
0.84
0.16
2.6
2.0
3.86
1.29
ug/l
0.38
11
119
15
172
0.87
0.16
3.8
2.2
0.65
0.61
%
0.31
15
172
18
203
0.88
0.15
2.0
1.8
3.40
3.53
mmol/l
0.16
12
159
9
81
1.11
0.15
3.0
1.8
—
—
—
0
0
25
272
0.91
0.12
2.1
2.0
3.49
3.40
ratio
0.16
16
229
33
307
1.08
0.12
6.4
2.8
5.97
5.76
kpa
0.39
33
300
32
341
0.93
0.10
5.5
7.3
—
—
—
0
0
5
48
1.04
0.09
1.0
1.4
—
151.43
—
0
7
23
247
0.93
0.09
2.2
2.8
75.73
65.84
ml/min/173m2
0.52
11
105
93
905
1.04
0.09
5.4
3.9
0.00
0.00
estimate
0.50
34
310
21
195
1.08
0.08
1.1
1.2
173.83
178.22
u/ml
—
6
83
7
68
1.03
0.08
1.3
1.7
—
—
—
0
0
7
81
0.86
0.07
1.1
1.5
—
—
—
0
0
7
83
0.84
0.07
1.6
1.8
—
—
—
0
0
9
102
0.88
0.06
1.8
3.3
25.78
24.90
mmol/l
—
9
97
9
105
0.85
0.06
1.6
1.4
—
—
—
0
0
135
1369
0.98
0.05
3.7
2.9
106.45
121.21
ug/l
0.65
128
1277
14
151
0.92
0.05
5.3
2.9
25.56
25.31
mmol/l
0.13
14
146
32
307
1.05
0.05
2.6
3.3
—
—
—
0
0
11
101
1.09
0.04
2.3
2.0
82.75
298.06
ug/l
2.83
11
96
12
129
0.93
0.03
1.4
1.4
0.22
0.31
mg/l
—
5
56
12
126
0.95
0.00
1.0
1.0
—
—
—
0
0
15
156
0.96
0.00
1.4
1.4
—
—
—
0
0
11
108
1.02
0.00
1.5
2.6
26.87
24.83
mmol/l
0.97
11
108
10
99
1.01
0.00
2.6
2.7
—
—
—
0
0
18
179
1.01
0.00
1.6
1.7
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
7
70
1.00
-0.00
1.3
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
7
78
0.90
-0.00
2.0
1.8
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
5
52
0.96
-0.00
1.2
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
6.08
—
0
5
0
7
0.00
-0.00
0.0
1.4
—
1.17
—
0
7
7
76
0.92
-0.00
1.9
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
47.80
—
0
5
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_XANTHELASMA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_XANTHELASMA | 1.022 [0.88, 1.19] | 0.785 |
| Birth year | 0.991 [0.98, 1.0] | 0.051 |
During the follow-up period (1.1.1998 — 31.12.2019), 206 out of 1522 females with H7_XANTHELASMA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_XANTHELASMA | 1.057 [0.87, 1.28] | 0.572 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 120 out of 633 males with H7_XANTHELASMA died.
Mortality risk
Mortality risk for people of age
years, who have H7_XANTHELASMA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.096% | 0.197% |
| 5 | 0.591% | 1.24% |
| 10 | 1.353% | 3.169% |
| 15 | 2.571% | 6.058% |
| 20 | 4.416% | 9.757% |
Relationships between endpoints
↥Index endpoint: H7_XANTHELASMA – Xanthelasma of eyelid
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data