Hyphaema and other vascular disorders of iris and ciliary body

H7_VASCCILIARY

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H21.0, H21.1
  • Hospital discharge: ICD-9 3644
  • Cause of death: ICD-10 H21.0, H21.1
  • Cause of death: ICD-9 3644

2 out of 7 registries used, show all original rules.

893

4. Check minimum number of events

None

893

5. Include endpoints

None

893

6. Filter based on genotype QC (FinnGen only)

803

Control definitions (FinnGen only)

Control exclude
H7_SCLERACORNEA

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 5991 2454 3510
Only index persons 5469 2239 3230
Unadjusted period prevalence (%)
Whole population 0.09 0.07 0.10
Only index persons 0.11 0.08 0.12
Median age at first event (years)
Whole population 60.60 71.92 52.62
Only index persons 59.68 71.26 51.65

-FinnGen-

Key figures

All Female Male
Number of individuals 803 347 456
Unadjusted period prevalence (%) 0.17 0.12 0.21
Median age at first event (years) 66.84 67.48 66.35

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
834
Matched controls
8340
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H21.0
ICD-10 Finland
Hyphaema
+∞
307.7
595
*
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
98.8
307.7
191
25
S01ED51
ATC
timolol, combinations; ophthalmic
23.9
307.7
433
361
H43.1
ICD-10 Finland
Vitreous haemorrhage
35.0
298.1
197
73
S01EA05
ATC
brimonidine; ophthalmic
33.4
297.5
200
78
S01EC01
ATC
acetazolamide; systemic
34.6
283.0
187
69
H21.1
ICD-10 Finland
Other vascular disorders of iris and ciliary body
+∞
282.9
255
*
WX140
NOMESCO Finland
Parabulbar anesthesy
15.2
216.9
213
184
CKC12
NOMESCO Finland
Photocoagulation of retina
15.2
186.8
179
147
S01EE01
ATC
latanoprost; ophthalmic
10.5
183.6
238
305
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
11.6
169.3
197
217
S01EA03
ATC
apraclonidine; ophthalmic
41.8
168.5
103
28
Z96.1
ICD-10 Finland
Presence of intraocular lens
7.2
168.2
353
772
S01ED01
ATC
timolol; ophthalmic
15.2
166.2
157
125
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
462.3
158.0
153
*
S01EC54
ATC
brinzolamide, combinations; ophthalmic
37.3
157.1
99
30
114
Kela drug reimbursment
Glaucoma
7.9
156.0
265
462
S05.1
ICD-10 Finland
Contusion of eyeball and orbital tissues
26.3
149.3
106
46
CHF05
NOMESCO Finland
Transscleral laser coagulation of ciliary body
68.0
145.6
80
13
CHB10
NOMESCO Finland
Puncture of anterior chamber of eye with irrigation
72.6
145.3
79
12
S01EC04
ATC
brinzolamide; ophthalmic
11.0
131.1
153
167
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
15.9
122.4
110
79
CKC20
NOMESCO Finland
Cryopexy of undetached retina
62.9
114.9
64
11
CKD40
NOMESCO Finland
Endophotocoagulation of retina
23.2
113.5
84
40
H3603, E113,
ICD-10 Finland
35.7
113.4
72
22
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
4.8
110.4
510
2051
XCW99
NOMESCO Finland
Other investigative procedure of eye
5.9
101.8
225
494
H20.1
ICD-10 Finland
Chronic iridocyclitis
+∞
97.9
92
*
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
5.9
97.3
209
446
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
7.4
91.3
146
231
XCK10
NOMESCO Finland
Photography of fundus of eye
5.7
91.3
202
441
H16.0
ICD-10 Finland
Corneal ulcer
14.0
91.0
87
69
CKC15
NOMESCO Finland
Panretinal photocoagulation
28.5
89.6
61
23
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
29.1
84.3
57
21
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.3
83.0
292
924
S01EC03
ATC
dorzolamide; ophthalmic
15.4
80.2
72
51
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
13.2
78.1
77
64
H40.10
ICD-10 Finland
Capsular glaucoma with pseudoexfoliation on the anterior lens capsule
9.1
75.9
98
120
CKD92
NOMESCO Finland
Combined vitrectomy and retinal procedure
18.8
72.0
58
33
XCK00
NOMESCO Finland
Perimetry
6.0
68.3
135
262
H34.8
ICD-10 Finland
Other retinal vascular occlusions
10.2
68.2
80
86
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
3.4
66.4
456
2182
H40.0
ICD-10 Finland
Glaucoma suspect
5.1
64.1
153
351
S01EE03
ATC
bimatoprost; ophthalmic
9.4
63.4
79
92
S05.9
ICD-10 Finland
Injury of eye and orbit, unspecified
20.1
56.6
44
23
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
3.1
56.6
472
2461
WX142
NOMESCO Finland
Sub-tenon anesthesy
22.6
55.4
41
19
CKD20
NOMESCO Finland
Removal of vitreous body substitute
25.5
55.2
39
16
H26.2
ICD-10 Finland
Complicated cataract
17.3
55.1
46
28
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
10.1
54.9
64
68
CJB10
NOMESCO Finland
Laser discission of secondary cataract
4.3
52.9
160
440
XCH00
NOMESCO Finland
Eye pressure measurement
5.8
52.0
102
195
CKC10
NOMESCO Finland
Local photocoagulation of retina
9.9
51.6
61
66
H40.9
ICD-10 Finland
Glaucoma, unspecified
9.3
50.6
63
73
CKD91
NOMESCO Finland
Extended vitrectomy through pars plana
11.3
50.2
54
51
A10AC01
ATC
insulin (human); parenteral
4.4
49.1
141
372
H3601, E103,
ICD-10 Finland
21.5
49.0
37
18
H3603, E103,
ICD-10 Finland
66.5
48.9
56
9
S01CA02
ATC
prednisolone and antiinfectives; ophthalmic
19.9
48.6
38
20
H33.0
ICD-10 Finland
Retinal detachment with retinal break
7.5
48.6
73
106
H26.4
ICD-10 Finland
After-cataract
3.8
48.5
174
539
A10AB01
ATC
insulin (human); parenteral
6.8
47.4
78
125
S01BA04
ATC
prednisolone; ophthalmic
10.4
46.7
53
54
A10AA02, ,
ATC
6.6
46.5
79
131
S01BC03
ATC
diclofenac; ophthalmic
10.2
46.1
53
55
A10AE04
ATC
insulin glargine; parenteral
3.8
45.7
160
486
S01EE05
ATC
tafluprost; ophthalmic
6.1
44.1
81
145
S01BA01
ATC
dexamethasone; ophthalmic
7.2
43.9
68
102
A10AB04
ATC
insulin lispro; parenteral
7.3
43.8
67
99
A10AA01, ,
ATC
8.0
43.8
61
81
CHD50
NOMESCO Finland
Shunt operation on anterior chamber
231.9
43.3
44
*
A10AB05
ATC
insulin aspart; parenteral
4.1
42.0
129
356
CHC05
NOMESCO Finland
Iridotomy
11.6
41.8
44
40
H3601, E113,
ICD-10 Finland
9.1
40.9
51
59
T85.2
ICD-10 Finland
Mechanical complication of intraocular lens
55.2
39.9
47
9
T89
ICPC
Diabetes insulin dependent
5.7
39.9
78
148
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
4.8
39.9
97
223
S01BA07
ATC
fluorometholone; ophthalmic
11.9
39.8
41
36
H25.1
ICD-10 Finland
Senile nuclear cataract
2.6
39.6
358
1852
CKD10
NOMESCO Finland
Insufflation of vitreous cavity
9.1
39.1
49
57
WX100
NOMESCO Finland
Conjunctival surface anesthesia
3.2
38.5
182
665
E11.3
ICD-10 Finland
Type 2 diabetes mellitus, with ophthalmic complications
6.1
38.4
70
124
H36.01
ICD-10 Finland
Diabetic maculopathy
9.9
38.3
45
48
H20.9
ICD-10 Finland
Iridocyclitis, unspecified
139.9
38.1
40
*
S01EE04
ATC
travoprost; ophthalmic
8.0
37.3
52
69
XCD10
NOMESCO Finland
Electrophysiological examination of eye
7.1
36.9
57
85
S01EX03, ,
ATC
7.4
36.4
54
77
S01BC05
ATC
ketorolac; ophthalmic
5.0
35.5
81
176
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
5.0
33.8
77
167
WX002
NOMESCO Finland
Sedation and analgesia
2.7
33.2
225
996
CHD05
NOMESCO Finland
Selective lasertrabeculoplasty
5.4
32.3
66
130
W22
ICD-10 Finland
Striking against or struck by other object(s)
4.0
32.1
97
263
CA1AE
NOMESCO Finland
Eye and orbita ultrasound examination
33.1
31.5
41
13
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
5.3
31.3
65
130
A10AE05
ATC
insulin detemir; parenteral
4.2
31.3
88
226
H04AA01
ATC
glucagon; nasal, parenteral
8.1
30.9
42
54
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
3.9
30.8
99
280
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
5.2
30.3
64
130
CKD15
NOMESCO Finland
Injection of vitreous substitute
36.1
29.9
38
11
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
6.7
29.7
48
75
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
7.7
29.5
42
57
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
5.7
28.7
55
102
NHQ40
NOMESCO Finland
Amputation of toe
7.6
28.6
41
56
XCD20
NOMESCO Finland
Photoangiography of eye
8.2
28.3
38
48
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
6.2
27.6
48
81
ZXA00
NOMESCO Finland
Right side
2.3
27.5
284
1511
CKD70
NOMESCO Finland
Excision of preretinal or epiretinal membrane
7.8
26.9
38
51
CKD94
NOMESCO Finland
Combined vitrectomy and procedure on lens through pars plana
7.5
26.9
39
54
H53.9
ICD-10 Finland
Visual disturbance, unspecified
4.6
25.9
64
148
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
22.7
25.8
37
17
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
10.3
25.7
29
29
H57.1
ICD-10 Finland
Ocular pain
5.3
25.3
52
103
H26.02
ICD-10 Finland
Presenil cataract
6.3
25.2
43
71
ZXA10
NOMESCO Finland
Bilateral
2.4
24.8
208
1004
CS494
NOMESCO Finland
Other visual field testing
5.8
24.2
45
81
CKD93
NOMESCO Finland
Extended combined procedure on vitreous body and retina
42.8
23.7
29
7
CHF15
NOMESCO Finland
Cryotherapy of ciliary body
123.4
22.7
24
*
W44
ICD-10 Finland
Foreign body entering into or through eye or natural orifice
8.2
22.3
30
38
H36.09*E11.3
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic retinopathy
17.7
21.9
34
20
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
2.7
21.5
128
521
CHD00
NOMESCO Finland
Laser trabeculoplasty
7.4
21.3
31
43
M08.4
ICD-10 Finland
Pauciarticular juvenile arthritis
51.4
21.2
25
5
H04.10
ICD-10 Finland
Dry eye syndrome
2.9
21.2
113
434
H27.1
ICD-10 Finland
Dislocation of lens
28.9
21.1
28
10
H40.4
ICD-10 Finland
Glaucoma secondary to eye inflammation
215.2
20.7
21
*
ZXA05
NOMESCO Finland
Left side
2.1
20.7
247
1369
CHD65
NOMESCO Finland
Nonpenetrating glaucoma surgery
17.5
20.6
32
19
A10AE06
ATC
insulin degludec; parenteral
4.4
20.5
53
127
Z49.1
ICD-10 Finland
Extracorporeal dialysis
8.2
20.1
27
34
H20.8
ICD-10 Finland
Other iridocyclitis
+∞
19.9
19
*
H16.9
ICD-10 Finland
Keratitis, unspecified
75.4
19.8
22
*
S01FA04
ATC
cyclopentolate; ophthalmic
18.3
19.7
30
17
H3600, E113,
ICD-10 Finland
7.9
19.6
27
35
TCA20
NOMESCO Finland
Peribulbar therapeutic injection into orbit
204.7
19.6
20
*
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
20.6
19.2
28
14
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
3.4
19.2
71
220
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
5.8
19.1
35
62
S01FA02
ATC
scopolamine; ophthalmic
28.6
18.8
25
9
Z3229
NOMESCO Finland
Other healthcare associate professional
2.8
18.5
98
374
E10
ICD-10 Finland
Type 1 diabetes mellitus
6.8
18.4
29
44
TK800
NOMESCO Finland
Hemodialysis
5.3
18.3
37
72
C03CA01
ATC
furosemide; systemic
1.9
17.9
330
2114
E10.1
ICD-10 Finland
Type 1 diabetes mellitus, With ketoacidosis
18.6
17.9
27
15
A10AD01
ATC
insulin (human); parenteral
5.4
17.6
35
67
H35.38
ICD-10 Finland
Preretinal fibrosis of the macula
3.9
17.5
53
143
H53.1
ICD-10 Finland
Subjective visual disturbances
3.0
17.4
83
299
ZXD05
NOMESCO Finland
Urgent procedure
2.0
17.2
277
1693
I65.2
ICD-10 Finland
Occlusion and stenosis of carotid artery
4.4
17.1
43
101
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
3.2
17.0
69
226
E10.8
ICD-10 Finland
Type 1 diabetes mellitus, With unspecified complications
7.1
16.6
25
36
CS1H4
NOMESCO Finland
Retinal nerve fibre layer imaging
4.9
16.5
37
79
M08.3
ICD-10 Finland
Juvenile polyarthritis (seronegative)
41.0
16.4
20
5
L01BA01
ATC
methotrexate; systemic
4.2
16.3
44
109
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
4.7
16.2
38
84
CHD15
NOMESCO Finland
Trabeculectomy and iridectomy
13.1
16.2
28
22
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
2.8
16.1
84
318
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
16.1
15.8
25
16
E11.5
ICD-10 Finland
Type 2 diabetes mellitus, with peripheral circulatory complications
4.8
15.8
36
78
H40.8
ICD-10 Finland
Other glaucoma
17.6
15.7
24
14
H3600, E103,
ICD-10 Finland
12.6
15.4
27
22
CHD99
NOMESCO Finland
Other filtering operation
23.9
15.2
21
9
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
2.7
15.0
83
324
N08.39*E11.2
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic nephropathy
5.6
14.9
28
51
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
5.2
14.7
30
59
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
4.7
14.6
34
75
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
5.9
14.5
26
45
WX006
NOMESCO Finland
Intravenous sedation or analgesia without general anesthesia
2.9
14.5
72
265
H36.00
ICD-10 Finland
Diabetic background retinopathy
6.1
14.4
25
42
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
4.0
14.4
41
106
H35.36
ICD-10 Finland
Macular cyst
17.3
14.4
22
13
E10.00
ICD-10 Finland
Insulin-dependent diabetes diabetic hypoglycemic coma
13.7
14.3
24
18
TCG10
NOMESCO Finland
Removal of sutures from cornea
22.7
14.3
20
9
103
Kela drug reimbursment
Diabetes, insulin-treated
1.8
14.1
264
1674
CKD60
NOMESCO Finland
Anterior vitrectomy
10.3
14.0
27
27
S01EE51
ATC
latanoprost and netarsudil; ophthalmic
20.5
13.8
20
10
I50.0
ICD-10 Finland
Congestive heart failure
2.4
13.7
98
433
N18.0
ICD-10 Finland
End-stage renal disease
6.6
13.7
22
34
CG2S4
NOMESCO Finland
Photography of cornea
76.4
13.6
15
*
215
Kela drug reimbursment
Diabetes, non-insulin-treated
1.9
13.5
232
1429
H34.1
ICD-10 Finland
Central retinal artery occlusion
14.1
13.3
22
16
I25.1
ICD-10 Finland
Atherosclerotic heart disease
1.8
13.2
236
1471
CJF45
NOMESCO Finland
Removal and implantation of artificial lens in anterior chamber with iridectomy or iridotomy
28.9
13.0
17
6
H25.8
ICD-10 Finland
Other senile cataract
2.2
13.0
119
585
L04AB04
ATC
adalimumab; parenteral
5.7
12.9
24
43
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.8
12.8
299
2013
H40.3
ICD-10 Finland
Glaucoma secondary to eye trauma
32.6
12.6
16
5
B03XA02
ATC
darbepoetin alfa; parenteral
4.3
12.6
33
80
E10.4
ICD-10 Finland
Type 1 diabetes mellitus, With neurological complications
17.6
12.6
19
11
ZX198
NOMESCO Finland
Other local administration
9.5
12.5
25
27
L04AA06
ATC
mycophenolic acid; systemic
5.1
12.5
26
52
Z3231
NOMESCO Finland
Registered nurse
1.8
12.4
241
1537
B01AC04
ATC
clopidogrel; oral
1.9
12.3
174
1002
V03AE01
ATC
polystyrene sulfonate; oral
5.0
12.2
26
53
S05.0
ICD-10 Finland
Injury of conjunctiva and corneal abrasion without mention of foreign body
4.6
12.2
29
65
N18.8
ICD-10 Finland
Other chronic renal failure
4.1
12.2
33
82
I50.9
ICD-10 Finland
Heart failure, unspecified
1.9
12.1
166
946
CKD95
NOMESCO Finland
Extended combined vitectomy and lens procedure through pars plana
27.1
12.1
16
6
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.3
12.0
100
472
CD2S4
NOMESCO Finland
Photography of eye
14.9
11.8
19
13
L04AA01
ATC
[U] ciclosporin
9.1
11.8
24
27
J01DB01
ATC
cefalexin; oral
1.9
11.7
669
5704
H26.3
ICD-10 Finland
Drug-induced cataract
12.8
11.7
20
16
H44.5
ICD-10 Finland
Degenerated conditions of globe
65.9
11.6
13
*
H54.4
ICD-10 Finland
Blindness, monocular
19.2
11.6
17
9
H43.8
ICD-10 Finland
Other disorders of vitreous body
2.3
11.5
89
407
H40.20
ICD-10 Finland
Acute glaucoma with closed ventricular angle
13.9
11.5
19
14
3644A
ICD-9 Finland
Disorders of iris and ciliary body, Vascular disorders of iris and ciliary body
+∞
11.5
11
*
Z94.7
ICD-10 Finland
Corneal transplant status
+∞
11.5
11
*
H19.1*B00.5
ICD-10 Finland
Herpesviral keratoconjunctivitis
+∞
11.5
11
*
H18.1
ICD-10 Finland
Bullous keratopathy
+∞
11.5
11
*
ZXE10
NOMESCO Finland
More than one and less than three hours
1.7
11.5
299
2063
J01FF01
ATC
clindamycin; systemic
1.8
11.3
229
1471
177
Kela drug reimbursment
Insulin glargine 300 U / ml
4.4
11.3
28
65
PAF14
NOMESCO Finland
Thrombendarterectomy of internal carotid artery
4.5
11.3
27
61
S01AD03
ATC
aciclovir; ophthalmic
4.0
11.1
31
79
S01FA01
ATC
atropine; ophthalmic
14.1
11.0
18
13
XCH05
NOMESCO Finland
Eye pressure longterm registration
8.4
10.9
23
28
SPAT1262
SPAT
Handing over of treatment supplies
1.9
10.8
157
909
127
Kela drug reimbursment
Transplant complication
5.2
10.8
22
43
H33.3
ICD-10 Finland
Retinal breaks without detachment
3.4
10.8
38
114
H3603, E107,
ICD-10 Finland
60.8
10.6
12
*
CHD35
NOMESCO Finland
Laser goniopuncture
14.4
10.5
17
12
F01
ICPC
Eye pain
4.0
10.5
30
78
A11CC03
ATC
alfacalcidol; systemic
3.7
10.4
33
92
A02BC02
ATC
pantoprazole; systemic
1.7
10.4
550
4497
H54.1
ICD-10 Finland
Severe visual impairment, binocular
111.4
10.4
11
*
H28.0*E10.3
ICD-10 Finland
Other specified diabetes mellitus - Diabetic cataract
111.4
10.4
11
*
H221, M084,
ICD-10 Finland
+∞
10.4
10
*
SPAT1009
SPAT
Measurement of intraocular pressure
5.2
10.4
21
41
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.0
10.3
130
717
A10BB01
ATC
glibenclamide; oral
2.8
10.3
51
188
M08.0
ICD-10 Finland
Juvenile rheumatoid arthritis
23.7
10.3
14
6
H40
ICD-10 Finland
Glaucoma
7.6
10.2
23
31
E10.6
ICD-10 Finland
Type 1 diabetes mellitus, With other specified complications
13.3
10.2
17
13
L28
ICPC
Limited function/disability (L)
1.8
10.1
182
1127
C08CA01
ATC
amlodipine; oral
1.6
10.0
334
2436
TPH04
NOMESCO Finland
Cathetrisation of vein
1.7
9.9
197
1253
C07AB07
ATC
bisoprolol; oral
1.6
9.9
426
3300
S00.1
ICD-10 Finland
Contusion of eyelid and periocular area
3.8
9.8
30
82
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.6
9.7
410
3155
CL2L4
NOMESCO Finland
Wide-field fundus photography for diabetic retinopathy screening
55.7
9.7
11
*
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
8.5
9.6
20
24
CA1AD
NOMESCO Finland
Orbita CT
101.1
9.4
10
*
H54.0
ICD-10 Finland
Blindness, binocular
101.1
9.4
10
*
CJF30
NOMESCO Finland
Reduction of dislocation of artificial lens
30.4
9.4
12
*
CKD99
NOMESCO Finland
Other intraoclular operations on vitreous body and retina
+∞
9.4
9
*
L04AX03
ATC
methotrexate; systemic
2.2
9.4
80
381
H26.1
ICD-10 Finland
Traumatic cataract
12.5
9.4
16
13
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.3
9.3
76
355
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
8.8
9.3
19
22
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
9.7
9.3
18
19
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
1.7
9.2
212
1400
N19
ICD-10 Finland
Unspecified kidney failure
2.8
9.2
47
176
PEF23
NOMESCO Finland
Thrombendarterectomy of femoral artery
4.4
9.2
23
54
L04AD01
ATC
ciclosporin; systemic
4.5
9.1
22
50
A12AA04
ATC
calcium carbonate; oral
4.7
9.1
21
46
Z49.0
ICD-10 Finland
Preparatory care for dialysis
8.4
9.1
19
23
H35.6
ICD-10 Finland
Retinal haemorrhage
8.4
9.1
19
23
PF1AT
NOMESCO Finland
Intravascular dilatation of arteries of knee, lower leg and ankle (PTA)
7.2
9.1
21
30
V03AE02
ATC
sevelamer; oral
15.8
9.1
14
9
H30.2
ICD-10 Finland
Posterior cyclitis
37.1
9.0
11
*
H18.8
ICD-10 Finland
Other specified disorders of cornea
37.1
9.0
11
*
SPAT1225
SPAT
Implementation of podiatry rehabilitation plan
3.6
9.0
29
82
CJ2M4
NOMESCO Finland
Scans and measurement printouts for intraocular lens power calculation
7.6
9.0
20
27
H33.4
ICD-10 Finland
Traction detachment of retina
18.8
8.9
13
7
I70.9
ICD-10 Finland
Generalized and unspecified atherosclerosis
3.7
8.9
28
78
M45
ICD-10 Finland
Ankylosing spondylitis
4.6
8.9
21
47
F29
ICPC
Eye symptom/complaint other
2.1
8.9
90
459
S97
ICPC
Chronic ulcer skin
2.3
8.9
70
323
S18
ICPC
Laceration/cut
1.6
8.8
384
2954
QDA10
NOMESCO Finland
Incision of skin of lower limb
10.8
8.8
16
15
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
7.3
8.8
20
28
CG2T4
NOMESCO Finland
Topography assessment of cornea
14.2
8.7
14
10
H44.0
ICD-10 Finland
Purulent endophthalmitis
50.5
8.7
10
*
H01
ICPC
Ear pain/earache
2.0
8.7
93
484
AA1AD
NOMESCO Finland
CT of head and brain
1.6
8.6
259
1826
ZXE00
NOMESCO Finland
One hour or less
1.6
8.6
298
2172
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
2.9
8.6
41
148
TCG00
NOMESCO Finland
Protection of cornea and sclera with soft lens
27.8
8.5
11
*
H35.31
ICD-10 Finland
Senile macular degeneration (atrophic)(exudative)
2.5
8.4
51
209
H3603, E117,
ICD-10 Finland
+∞
8.3
8
*
TCA15
NOMESCO Finland
Retrobulbar therapeutic injection into orbit
+∞
8.3
8
*
PE1AT
NOMESCO Finland
Femoral artery PTA
4.4
8.2
20
46
H3602, E103,
ICD-10 Finland
33.7
8.1
10
*
G63.2*E10.4
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic polyneuropathy
17.4
8.1
12
7
H34.2
ICD-10 Finland
Other retinal artery occlusions
9.0
8.1
16
18
L04AB06
ATC
golimumab; parenteral
10.2
8.0
15
15
CK2K4
NOMESCO Finland
Red-free imaging of ocular fundus
22.3
8.0
11
5
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
1.9
8.0
110
624
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
2.3
7.9
57
253
E11.6
ICD-10 Finland
Type 2 diabetes mellitus, with other specified complications
3.3
7.9
29
90
C10AA05
ATC
atorvastatin; oral
1.5
7.8
344
2631
H25.0
ICD-10 Finland
Senile incipient cataract
2.3
7.8
61
280
N02BE01
ATC
paracetamol; systemic, rectal
1.8
7.8
719
6480
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
2.5
7.8
47
192
W20
ICD-10 Finland
Struck by thrown, projected or falling object(s)
6.5
7.7
19
30
C09AA02
ATC
enalapril; systemic
1.7
7.7
170
1105
CKA10
NOMESCO Finland
Biopsy of vitreous body
45.4
7.7
9
*
A46
ICD-10 Finland
Erysipelas
1.8
7.7
134
817
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
2.4
7.6
52
225
M86.9
ICD-10 Finland
Osteomyelitis, unspecified
6.8
7.6
18
27
CKD50
NOMESCO Finland
Endodiathermy of retina
18.6
7.6
11
6
WW200
NOMESCO Finland
Immunization
3.4
7.6
27
82
S01EB01
ATC
pilocarpine; ophthalmic
7.2
7.5
17
24
L04AD02
ATC
tacrolimus; systemic
7.2
7.5
17
24
H17.9
ICD-10 Finland
Corneal scar and opacity, unspecified
80.8
7.4
8
*
RJ521, ,
NOMESCO Finland
80.8
7.4
8
*
CH2S4
NOMESCO Finland
Photography of iris
80.8
7.4
8
*
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
2.0
7.4
86
461
B01AC30
ATC
platelet aggregation inhibitors excl. heparin - combinations
2.1
7.4
66
321
H35.0
ICD-10 Finland
Background retinopathy and retinal vascular changes
8.5
7.3
15
18
CK9F4
NOMESCO Finland
Fluorescein angiography (FAG) of choroid and retina
11.0
7.3
13
12
Z49.2
ICD-10 Finland
Other dialysis
9.5
7.3
14
15
CGG60
NOMESCO Finland
Reinforcement of sclera using graft
+∞
7.3
7
*
H18.2
ICD-10 Finland
Other corneal oedema
+∞
7.3
7
*
3641A
ICD-9 Finland
Disorders of iris and ciliary body, Chronic iridocyclitis
+∞
7.3
7
*
H22.1
ICD-10 Finland
Iridocyclitis in other diseases classified elsewhere
+∞
7.3
7
*
H27.0
ICD-10 Finland
Aphakia
15.9
7.2
11
7
C10AA01
ATC
simvastatin; oral
1.5
7.2
356
2777
C02AC05
ATC
moxonidine; oral
2.4
7.2
49
212
N17.8
ICD-10 Finland
Other acute renal failure
4.5
7.2
17
38
TNX39
NOMESCO Finland
Other orthopedic bandage, unspecified region
4.5
7.2
17
38
L04AA17
ATC
[U] adalimumab
20.2
7.1
10
5
S05.8
ICD-10 Finland
Other injuries of eye and orbit
12.2
7.1
12
10
N08.39
ICD-10 Finland
Glomerular disorders in diabetes mellitus microalbuminuria
10.1
7.0
13
13
CS434
NOMESCO Finland
Visual field testing with Humphrey automated perimetry
3.5
7.0
24
71
R53
ICD-10 Finland
Malaise and fatigue
1.6
7.0
213
1497
H02AB06
ATC
prednisolone; systemic
1.5
7.0
369
2914
I21.41
ICD-10 Finland
Acute subendocardial infarction stenosed coronary artery
2.3
6.9
50
222
AN1
HP
Coronary angiography
1.8
6.9
105
613
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
2.2
6.9
57
268
A10AD05
ATC
insulin aspart; parenteral
3.2
6.9
26
82
R06.0
ICD-10 Finland
Dyspnoea
1.5
6.9
227
1624
C09AA05
ATC
ramipril; oral
1.5
6.8
222
1582
205
Kela drug reimbursment
Chronic hypertension
1.5
6.8
232
1670
196
Kela drug reimbursment
Paricalcitol and cinacalcet
11.0
6.8
12
11
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
1.9
6.8
85
467
Z94.0
ICD-10 Finland
Kidney transplant status
6.2
6.8
17
28
C01DA14
ATC
isosorbide mononitrate; oral
1.7
6.8
153
999
S01ED02
ATC
betaxolol; ophthalmic
5.7
6.8
18
32
I10
ICD-10 Finland
Essential (primary) hypertension
1.5
6.8
500
4202
2504B
ICD-9 Finland
Diabetes mellitus, Diabetes with renal manifestations[DIABETES MELLITUS CUM COMPLICATIONE OCULI ,TYYPPI I]
16.8
6.8
10
6
TQW11
NOMESCO Finland
Vacuum treatment of wound
3.3
6.7
25
78
TCF00
NOMESCO Finland
Subconjunctival therapeutic injection
22.7
6.7
9
*
CG2X4
NOMESCO Finland
Optical coherence tomography (OCT) of cornea
22.7
6.7
9
*
Z2221
NOMESCO Finland
Medical doctor
1.6
6.7
203
1425
L04AB05
ATC
certolizumab pegol; parenteral
12.4
6.6
11
9
X59
ICD-10 Finland
Exposure to unspecified factor
1.6
6.6
151
990
F28
ICPC
Limited function/disability (F)
8.8
6.6
13
15
B03XA03
ATC
methoxy polyethylene glycol-epoetin beta; parenteral
8.8
6.6
13
15
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.5
6.6
390
3137
H25.2
ICD-10 Finland
Senile cataract, morgagnian type
10.1
6.5
12
12
1LA05, ,
NOMESCO Finland
10.1
6.5
12
12
E0000UV, ,
ATC
1.5
6.5
312
2406
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.6
6.5
176
1201
R4160
NOMESCO Finland
Other therapy enhancing rehabilitation
3.7
6.5
20
55
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.5
6.5
211
1501
CS3P4
NOMESCO Finland
Optic nerve head stereophotography
5.8
6.5
17
30
Z01.8
ICD-10 Finland
Other specified special examinations
1.6
6.5
172
1169
CJF20
NOMESCO Finland
Removal of artificial lens
70.4
6.4
7
*
H17.8
ICD-10 Finland
Other corneal scars and opacities
70.4
6.4
7
*
7143D
ICD-9 Finland
Rheumatoid arthritis and other inflammatory polyarthropathies, Juvenile chronic polyarthritis[OLIGARTHRITIS JUVENILIS]
70.4
6.4
7
*
H18.5
ICD-10 Finland
Hereditary corneal dystrophies
70.4
6.4
7
*
H31.4
ICD-10 Finland
Choroidal detachment
70.4
6.4
7
*
R1220
NOMESCO Finland
Psychological examination of need and possibilities to rehabilitation
7.5
6.4
14
19
M72.0
ICD-10 Finland
Palmar fascial fibromatosis [Dupuytren]
2.5
6.4
38
155
QDG20
NOMESCO Finland
Operation for chronic ulcer or fistula of skin of lower limb
6.0
6.3
16
27
WX110
NOMESCO Finland
Infiltration anesthesia
1.5
6.3
536
4598
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.5
6.3
226
1641
A10BX01
ATC
guar gum; oral
2.5
6.3
39
162
H221, M083,
ICD-10 Finland
+∞
6.3
6
*
H22.1*M45
ICD-10 Finland
Iridocyclitis in ankylosing spondylitis
+∞
6.3
6
*
H36.8*I70.8
ICD-10 Finland
Atherosclerotic retinopathy
+∞
6.3
6
*
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.5
6.2
201
1426
X57
ICD-10 Finland
Unspecified privation
3.1
6.2
25
82
Z5132
NOMESCO Finland
Nursing associate professional
7.1
6.2
14
20
TNX33
NOMESCO Finland
Custom moulded cast, unspecified region
2.4
6.2
43
188
N17.9
ICD-10 Finland
Acute renal failure, unspecified
2.4
6.2
43
188
R60.0
ICD-10 Finland
Localized oedema
1.7
6.2
107
650
D23.9
ICD-10 Finland
Benign neoplasm: Skin, unspecified
3.3
6.2
22
67
B05DA
ATC
Isotonic solutions
7.7
6.1
13
17
J01MA12
ATC
levofloxacin; systemic
1.6
6.1
153
1023
3626
FHL
Extracapsular cataract surgery and implantation of an artificial lens
3.8
6.1
18
48
PA6AD
NOMESCO Finland
CT of neck arteries
2.6
6.1
35
140
CFW99
NOMESCO Finland
Other operation on conjunctiva
12.6
6.1
10
8
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
8.7
6.1
12
14

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
182
854
2.45
22.90
2.4
1.7
—
—
—
0
0
51
143
3.73
15.97
1.8
1.4
—
—
—
0
0
204
1169
1.99
14.94
5.0
2.5
20.32
22.61
%
1.88
188
1090
212
1249
1.94
14.24
4.9
2.5
2.12
2.28
g/l
4.16
194
1154
468
3538
1.74
13.41
21.7
16.8
1.32
1.31
inr
0.21
401
2989
219
1329
1.88
13.33
4.9
2.6
11.26
12.66
umol/l
2.39
205
1239
168
938
1.99
13.09
3.3
2.9
1.74
1.79
%
0.32
153
848
31
70
4.56
12.93
1.1
1.2
—
—
—
0
0
341
2381
1.73
12.86
8.2
6.3
—
—
—
0
0
87
375
2.47
12.83
1.8
2.1
1.86
1.50
g/l
2.57
76
336
319
2192
1.74
12.70
5.8
4.4
—
—
—
0
0
482
3720
1.70
12.39
13.8
7.3
1.20
1.21
mmol/l
0.84
420
3193
443
3354
1.68
12.14
12.1
6.6
1.20
1.21
mmol/l
0.76
411
3075
115
573
2.17
12.11
7.3
3.8
129.20
91.82
ng/l
2.35
99
500
43
130
3.43
12.06
1.8
1.4
171.11
168.71
au/ml
0.06
18
37
188
1119
1.88
12.02
3.0
2.1
—
—
—
0
0
476
3681
1.68
11.97
8.4
6.4
1.78
1.97
e9/l
1.75
424
3237
440
3336
1.68
11.91
8.7
6.5
0.64
0.66
%
0.40
421
3144
479
3721
1.67
11.74
8.5
6.6
0.20
0.19
e9/l
0.30
429
3257
440
3345
1.67
11.71
8.4
6.4
2.83
2.90
%
0.24
420
3156
468
3621
1.67
11.58
8.3
6.3
0.04
0.04
e9/l
0.41
417
3125
439
3346
1.66
11.48
8.8
6.6
9.10
9.00
%
0.30
420
3161
440
3358
1.66
11.43
8.4
6.3
58.33
57.74
%
0.45
424
3223
466
3612
1.66
11.37
8.3
6.3
0.62
0.60
e9/l
1.15
417
3109
174
1028
1.88
11.32
14.8
5.6
1.13
1.02
mmol/l
4.86
164
948
352
2542
1.67
11.31
5.3
3.5
6.80
7.70
mmol/l
3.33
302
2163
290
2003
1.69
10.97
3.1
2.3
2.94
3.00
mg/l
0.16
256
1702
427
3274
1.62
10.58
3.9
2.9
—
—
estimate
—
0
0
332
2394
1.64
10.53
5.6
3.5
99.01
54.26
mg/l
2.11
239
1596
338
2451
1.64
10.47
6.4
4.2
20.71
9.35
mg/mmol
2.46
234
1598
441
3414
1.62
10.46
8.7
6.5
25.69
26.93
%
1.55
425
3252
317
2280
1.63
10.04
2.6
2.2
228.12
240.16
u/l
0.09
303
2164
67
288
2.44
9.94
2.6
2.2
723.06
348.00
ug/l
0.65
67
275
527
4294
1.62
9.86
8.0
5.3
7.52
6.74
mmol/l
7.71
512
4093
745
6701
2.05
9.46
27.1
17.5
24.96
26.26
mg/l
0.59
644
5601
149
884
1.83
9.45
1.5
1.3
528.89
421.91
titre
0.45
36
188
204
1331
1.71
9.31
2.0
1.8
1174.96
1190.38
nmol/l
0.07
168
1009
309
2243
1.60
9.25
8.2
4.2
7.39
7.40
ph
1.76
232
1610
418
3256
1.57
9.22
2.6
2.2
89.82
95.47
pmol/l
1.76
239
1736
497
4029
1.58
9.19
10.3
9.8
4.32
4.22
e9/l
0.41
440
3529
41
143
2.96
9.13
1.3
1.2
265.93
249.65
u/ml
0.15
29
80
621
5323
1.65
8.96
10.5
8.5
82.73
80.06
u/l
0.72
602
5049
127
736
1.86
8.64
3.9
3.0
64.96
68.90
e9/l
0.64
104
568
551
4614
1.57
8.51
6.5
5.0
1129.69
3193.22
e6/l
0.93
13
74
323
2405
1.56
8.49
3.9
3.4
3160.86
1551.75
ng/l
2.57
287
2091
401
3134
1.54
8.45
3.1
2.5
75.49
77.14
nmol/l
0.51
360
2795
317
2354
1.56
8.41
3.8
2.6
—
—
—
0
0
121
697
1.86
8.39
13.2
8.3
—
—
—
0
0
468
3787
1.54
8.38
6.3
6.8
11.72
12.07
umol/l
0.20
450
3620
153
954
1.74
8.13
7.6
7.5
7.41
7.42
ph
0.73
84
562
112
642
1.86
7.87
2.1
3.2
66.22
66.51
g/l
0.15
105
590
96
525
1.94
7.78
2.1
2.8
—
—
—
0
0
150
942
1.72
7.75
7.7
7.6
0.12
1.07
mmol/l
1.93
131
771
26
76
3.50
7.72
1.2
1.2
—
—
—
0
0
261
1891
1.55
7.57
3.6
2.9
373.48
356.17
umol/l
1.53
224
1667
412
3289
1.50
7.56
8.0
5.2
34.54
35.31
g/l
2.14
390
3076
217
1510
1.59
7.49
1.4
1.3
1.66
1.67
u/ml
0.00
60
412
688
6146
1.68
7.46
5.8
5.1
2.03
1.96
mu/l
0.29
642
5627
407
3251
1.49
7.38
5.0
3.1
144.30
144.50
ug/l
0.01
382
2995
54
246
2.28
7.07
2.5
3.7
1.56
2.76
ratio
1.72
36
152
130
812
1.71
6.81
8.7
3.5
1.12
1.86
mmol/l
1.65
119
687
134
844
1.70
6.81
8.7
3.5
7.36
7.38
ph
2.68
87
512
57
270
2.19
6.80
2.0
2.7
10.68
10.51
g/l
0.10
52
240
297
2254
1.49
6.78
4.5
3.4
—
—
—
0
0
85
469
1.90
6.71
8.7
3.4
23.42
24.20
mmol/l
1.82
85
464
56
268
2.17
6.53
2.6
3.9
60.49
75.25
mg/l
0.27
47
232
298
2279
1.48
6.49
4.2
2.7
61.31
95.60
u/l
0.48
276
2138
56
269
2.16
6.47
2.6
3.9
42.52
58.56
mg/l
0.52
46
233
240
1763
1.51
6.35
4.2
2.6
—
—
—
0
0
61
310
2.04
6.10
1.4
1.5
—
15.11
—
0
9
445
3702
1.43
6.08
5.2
4.1
0.00
0.00
estimate
-0.00
88
810
373
3014
1.43
5.93
4.7
3.6
6.22
6.22
ph
0.02
202
1698
448
3742
1.43
5.92
5.2
4.1
0.17
4.23
estimate
0.75
90
828
450
3765
1.42
5.87
5.3
4.1
12.50
0.40
estimate
0.47
80
771
85
491
1.81
5.82
10.1
8.1
24.26
24.82
mmol/l
0.74
85
486
75
418
1.87
5.76
2.5
2.5
35.38
19.29
au/ml
—
6
32
123
791
1.65
5.75
2.4
1.6
—
—
—
0
0
761
7105
1.81
5.62
34.5
22.9
95.41
81.40
umol/l
6.65
755
7012
288
2238
1.44
5.59
2.0
1.8
19.11
19.94
nmol/l
0.40
244
1887
13
21
6.27
5.40
5.4
4.4
—
—
—
0
0
52
261
2.06
5.40
1.3
1.3
—
—
—
0
0
143
969
1.57
5.39
2.3
1.7
—
—
—
0
0
46
222
2.13
5.29
1.3
1.3
—
—
—
0
0
297
2340
1.42
5.28
2.9
3.3
34.94
33.59
u/l
0.16
278
2209
15
30
5.07
5.27
1.1
1.2
—
—
—
0
0
15
30
5.07
5.27
1.0
1.0
1137.87
1232.47
miu/ml
0.17
15
30
720
6647
1.61
5.26
6.9
5.8
2.45
2.62
mmol/l
5.56
680
6130
44
210
2.16
5.20
1.7
1.5
210.64
285.41
ug/g
1.88
28
130
184
1330
1.49
5.14
1.5
1.5
2.43
2.55
g/l
0.36
119
810
752
7028
1.71
5.12
16.1
12.3
25.57
26.32
u/l
0.66
740
6828
13
23
5.72
5.08
2.1
1.7
—
—
—
0
0
106
678
1.65
5.06
2.0
2.0
373.91
385.77
nmol/l
0.27
98
632
308
2459
1.40
5.02
4.9
3.6
66.25
104.58
e6/l
0.50
251
1895
55
291
1.95
4.95
5.1
4.2
24.43
24.95
mmol/l
0.67
50
269
23
83
2.82
4.91
4.6
2.6
1.75
1.49
g/24h
0.16
12
51
771
7269
1.80
4.90
40.1
26.2
91.13
91.18
fl
0.10
766
7178
771
7271
1.80
4.87
40.2
26.3
4.39
4.49
e12/l
4.64
756
7101
771
7271
1.80
4.87
41.2
26.8
39.30
40.34
%
4.84
765
7172
771
7271
1.80
4.87
40.1
26.2
30.21
30.36
pg
1.62
766
7180
771
7272
1.80
4.85
40.3
26.3
6.93
6.86
e9/l
0.39
757
7103
353
2896
1.38
4.84
5.1
4.1
53.32
60.35
ng/l
0.13
276
2173
771
7273
1.80
4.84
40.6
26.5
131.70
135.27
g/l
7.01
766
7181
314
2528
1.39
4.83
3.9
3.5
2.34
2.35
mmol/l
0.91
283
2291
84
512
1.71
4.81
4.2
4.8
—
—
—
0
0
574
5099
1.40
4.81
4.6
4.1
15.13
14.92
pmol/l
1.26
533
4631
221
1675
1.43
4.80
5.2
4.4
1.02
1.02
kg/l
0.49
154
1131
735
6850
1.61
4.80
35.0
21.2
4.03
3.99
mmol/l
2.39
727
6697
337
2751
1.38
4.74
5.8
4.2
90.34
121.79
e6/l
0.39
261
1976
734
6843
1.61
4.73
34.2
21.1
139.42
139.57
mmol/l
0.90
727
6703
770
7268
1.77
4.72
40.3
26.3
242.21
243.38
e9/l
0.19
756
7119
165
1186
1.49
4.71
2.4
1.9
—
—
—
0
0
200
1493
1.45
4.71
5.5
4.2
387.35
355.71
ng/l
0.07
176
1217
704
6505
1.53
4.69
5.9
5.0
1.39
1.42
mmol/l
1.32
661
5992
62
352
1.82
4.53
1.6
1.2
—
—
—
0
0
8
8
10.08
4.52
22.0
5.0
5.74
6.36
mmol/l
—
8
8
104
681
1.60
4.52
2.7
2.5
5.83
7.41
ug/l
0.81
87
609
706
6540
1.52
4.51
5.9
5.1
4.30
4.51
mmol/l
5.93
665
6071
685
6311
1.48
4.46
9.8
6.7
44.16
39.59
mmol/mol
14.12
644
5889
122
835
1.54
4.38
2.9
2.9
9.26
8.91
umol/l
0.06
104
747
223
1721
1.40
4.32
3.9
2.8
4.93
4.86
e6/l
0.04
211
1565
10
16
6.31
4.30
1.1
1.0
—
—
—
0
0
21
78
2.74
4.28
1.4
1.2
—
—
—
0
0
675
6216
1.45
4.26
5.0
4.3
1.32
1.29
mmol/l
0.36
629
5676
29
129
2.29
4.10
7.4
3.0
15.60
9.23
pmol/l
1.19
29
129
14
42
3.37
4.05
3.1
1.8
136.43
90.53
ng/l
0.43
14
42
201
1541
1.40
4.02
1.7
1.7
1.03
1.37
mg/l
1.81
156
1196
214
1660
1.39
3.99
5.4
4.0
0.00
0.14
—
5
22
85
548
1.61
3.95
1.8
1.8
—
—
—
0
0
261
2102
1.35
3.83
7.3
6.4
—
—
—
0
0
82
532
1.60
3.72
5.1
3.7
7.40
7.42
ph
1.47
73
447
729
6865
1.49
3.61
24.2
15.7
—
—
—
0
0
365
3106
1.31
3.61
15.3
12.0
0.00
0.00
e9/l
0.34
308
2560
25
111
2.29
3.58
8.0
5.5
12.56
11.56
mg/l
0.55
25
103
688
6414
1.42
3.56
6.0
5.3
6.50
6.00
mmol/l
6.83
631
5819
124
891
1.46
3.52
1.8
1.5
—
—
—
0
0
511
4563
1.31
3.49
3.6
3.3
52.71
51.45
u/l
0.11
487
4295
103
718
1.50
3.41
2.0
2.4
0.20
0.21
g/l
1.11
95
666
11
27
4.11
3.40
2.6
2.7
0.67
0.61
mmol/l
1.10
11
27
34
177
1.96
3.28
2.9
2.5
364.67
105.32
ug/min
0.90
19
107
61
380
1.65
3.28
5.1
3.8
—
—
—
0
0
75
494
1.57
3.22
1.3
1.2
—
—
—
0
0
154
1170
1.39
3.21
1.4
1.3
28.79
34.10
iu/ml
0.32
44
351
28
137
2.08
3.20
11.3
1.7
0.73
0.89
nmol/l
0.71
19
117
170
1314
1.37
3.19
4.0
3.2
1.12
1.04
e6/l
0.11
99
724
31
159
1.99
3.13
1.3
1.2
—
—
—
0
0
36
196
1.87
3.07
5.3
3.5
1.17
1.86
index
0.39
24
113
94
658
1.48
3.06
5.0
4.8
0.93
0.83
%
0.15
30
220
323
2756
1.28
2.98
2.1
1.9
1.41
1.35
mmol/l
0.48
279
2319
236
1933
1.31
2.98
3.8
3.1
0.00
0.05
—
10
55
95
671
1.47
2.96
10.6
4.4
7.34
7.36
ph
0.23
63
489
88
616
1.48
2.87
4.8
4.8
0.57
0.57
%
0.00
29
197
56
354
1.62
2.87
2.3
2.5
—
—
—
0
0
158
1230
1.35
2.82
4.1
3.3
1.75
2.02
e6/l
0.28
87
637
600
5547
1.29
2.78
33.2
21.6
13.96
13.72
%
3.68
594
5481
36
203
1.81
2.77
17.6
11.4
—
—
—
0
0
254
2121
1.28
2.74
4.7
3.4
0.27
0.49
e6/l
2.20
194
1579
95
682
1.44
2.73
4.6
2.5
29.17
34.83
u/l
1.30
82
575
88
623
1.46
2.72
4.7
4.9
0.16
0.11
%
0.29
25
186
10
29
3.48
2.69
3.1
1.9
112.40
150.90
e6/l
—
10
29
24
119
2.05
2.68
1.1
1.1
—
—
—
0
0
327
2836
1.25
2.54
5.3
4.0
1.28
0.03
estimate
0.49
79
677
24
122
2.00
2.52
3.0
3.0
4.80
4.51
e9/l
0.30
24
122
16
69
2.34
2.49
1.6
2.7
1381.50
1167.29
mg
0.12
16
69
250
2106
1.27
2.48
5.5
4.2
0.00
0.01
estimate
0.96
72
738
8
21
3.84
2.46
1.0
1.1
—
—
—
0
0
6
12
5.03
2.40
1.0
1.0
—
—
—
0
0
5
8
6.28
2.37
1.2
1.0
—
—
—
0
0
31
176
1.79
2.37
2.1
1.7
—
—
—
0
0
8
22
3.66
2.37
1.0
1.0
—
—
—
0
0
18
84
2.17
2.36
4.0
2.6
—
—
—
0
0
44
277
1.62
2.33
1.7
1.8
2.89
7.79
iu/ml
1.78
14
69
5
153
0.32
2.30
1.6
1.6
—
—
—
0
0
53
354
1.53
2.20
2.5
2.2
0.00
2.24
estimate
0.50
13
112
51
342
1.52
2.09
2.5
2.1
—
—
—
0
0
89
667
1.37
2.04
2.4
2.2
0.00
0.02
estimate
0.50
15
141
34
208
1.66
2.04
1.2
1.1
—
—
—
0
0
24
133
1.83
2.01
1.8
1.7
—
—
—
0
0
101
775
1.35
2.00
1.4
1.4
—
—
—
0
0
86
644
1.37
1.99
4.6
5.2
0.05
0.18
%
0.92
21
180
73
533
1.41
1.96
1.6
1.5
—
—
—
0
0
6
16
3.77
1.93
1.2
1.8
11.33
4.38
%
—
6
16
105
815
1.33
1.93
2.2
2.4
201.02
127.99
ug/g
0.58
88
651
33
205
1.63
1.88
1.3
1.2
80.00
100.48
titre
—
5
21
48
326
1.50
1.88
1.5
1.2
—
—
—
0
0
52
360
1.47
1.86
2.3
3.4
4.18
4.48
pmol/l
1.26
44
315
72
530
1.39
1.86
3.2
2.8
6.08
6.09
ph
0.00
53
373
21
115
1.85
1.84
2.1
1.7
1.45
1.65
mmol/l
0.89
21
110
6
17
3.55
1.84
1.2
1.7
27.83
29.41
%
—
6
17
183
1536
1.25
1.83
3.5
3.0
2.47
2.45
mmol/l
0.71
165
1384
15
73
2.07
1.81
2.9
2.6
—
—
—
0
0
27
161
1.70
1.80
2.6
2.0
4.35
39.22
iu/l
0.51
13
68
25
147
1.72
1.75
6.7
4.7
2.20
2.70
mmol/l
0.45
19
93
184
1555
1.24
1.73
1.9
1.8
421.36
22616670.48
pmol/l
1.20
155
1269
15
75
2.02
1.70
2.0
1.7
8.55
10.28
%
0.87
15
75
110
877
1.29
1.69
4.0
3.3
5.55
5.36
e9/l
0.06
90
761
48
335
1.46
1.67
2.7
2.9
—
—
—
0
0
28
175
1.62
1.59
2.8
2.2
124.74
127.22
g/l
0.19
19
137
37
249
1.51
1.55
1.4
1.2
0.82
1.91
u/ml
—
9
15
77
592
1.33
1.55
1.4
1.4
—
—
—
0
0
55
401
1.40
1.53
1.1
1.2
154.17
131.59
u/ml
0.13
20
161
114
927
1.27
1.51
1.3
1.2
—
—
—
0
0
310
2787
1.18
1.50
5.2
5.7
2.27
2.96
ug/l
0.94
270
2500
26
163
1.61
1.48
5.7
3.8
—
—
—
0
0
6
22
2.74
1.43
2.0
2.2
91.33
124.12
nmol/l
—
6
17
129
1072
1.24
1.43
1.3
1.3
3.69
10.38
u/ml
1.46
43
384
10
46
2.19
1.40
4.8
2.7
—
—
—
0
0
11
53
2.09
1.39
2.7
1.5
—
—
—
0
0
5
17
2.95
1.36
5.0
7.5
6.98
5.35
kpa
—
5
17
176
1520
1.20
1.34
4.1
3.0
510.79
542.56
mosm/kgh2o
1.44
159
1322
24
153
1.59
1.30
2.5
2.3
1773.47
6799.80
u/l
—
7
56
25
161
1.57
1.30
1.3
1.2
39.30
34.84
u/l
0.10
20
141
217
1916
1.18
1.28
1.4
1.4
—
—
—
0
0
10
48
2.10
1.28
1.2
1.1
—
—
—
0
0
11
55
2.01
1.27
1.7
1.2
97.27
101.25
pmol/l
0.10
11
55
9
45
2.01
1.23
3.4
2.1
0.64
0.57
e9/l
—
9
45
72
569
1.29
1.23
3.0
2.8
10.79
10.82
g/l
0.02
66
516
17
101
1.70
1.20
1.3
1.1
79.42
105.95
iu/ml
—
5
22
13
71
1.84
1.20
1.2
1.6
45.45
43.97
ng/l
0.02
13
71
75
599
1.28
1.18
8.8
3.7
1.21
1.22
mmol/l
1.32
67
513
24
158
1.53
1.15
3.5
2.8
62.54
59.24
%
0.70
24
158
20
126
1.60
1.15
3.5
2.4
0.94
0.88
%
0.21
15
95
20
126
1.60
1.15
1.1
1.1
—
—
—
0
0
32
225
1.44
1.13
1.7
1.6
18.97
7.67
u/ml
—
6
38
15
89
1.70
1.08
1.1
1.2
—
—
—
0
0
17
105
1.63
1.06
1.9
2.0
—
—
—
0
0
27
187
1.46
1.05
1.1
1.1
—
—
—
0
0
176
1555
1.17
1.03
6.7
4.9
—
—
—
0
0
5
22
2.28
1.03
3.2
2.1
—
—
—
0
0
10
53
1.90
1.01
1.2
1.2
—
—
—
0
0
10
53
1.90
1.01
1.3
2.0
44.81
38.21
%
—
10
53
12
68
1.78
1.01
4.2
3.6
12.17
12.46
index
—
6
48
226
2042
1.15
0.98
4.3
3.4
0.70
0.06
estimate
0.45
73
642
39
293
1.35
0.98
4.9
3.7
332.54
316.42
mg/l
0.07
24
124
9
50
1.81
0.97
1.4
1.3
—
—
—
0
0
42
320
1.33
0.96
1.4
1.6
0.17
0.34
mg/l
2.63
20
153
16
245
0.65
0.94
2.1
1.7
—
—
—
0
0
15
93
1.62
0.94
1.1
1.1
2.15
2.38
eliau/ml
—
6
39
6
28
2.15
0.91
1.7
1.7
38.22
40.39
g/l
—
6
28
14
86
1.64
0.91
1.3
1.2
—
—
—
0
0
283
2610
1.13
0.89
2.2
2.2
—
—
—
0
0
6
29
2.08
0.89
1.7
1.2
153.50
190.20
mmol/24h
—
6
29
17
112
1.53
0.85
3.5
2.6
32.29
32.71
pg
0.17
17
112
43
541
0.78
0.81
1.3
1.4
—
—
—
0
0
18
122
1.49
0.80
1.3
1.4
—
—
—
0
0
10
58
1.73
0.80
1.4
1.4
2.28
1.12
promille
—
10
47
22
156
1.42
0.79
2.8
4.0
18.34
31.66
mg/l
2.00
15
111
0
24
0.00
0.79
0.0
1.3
—
97.06
—
0
19
52
424
1.24
0.75
1.4
1.3
212.45
245.10
u/ml
0.09
46
393
5
24
2.09
0.74
1.2
1.4
26.40
27.08
s
—
5
24
229
2479
0.89
0.73
3.4
3.2
—
—
—
0
0
9
55
1.64
0.73
1.2
1.0
—
—
—
0
0
7
39
1.80
0.72
4.1
3.6
76.14
139.72
nmol/l
—
7
39
14
93
1.51
0.69
1.4
1.4
295.67
276.42
mosm/kgh2o
—
9
67
76
653
1.18
0.67
1.7
1.5
—
—
—
0
0
12
179
0.67
0.67
1.2
1.2
—
—
—
0
0
12
78
1.55
0.65
4.7
5.3
—
—
—
0
0
27
207
1.31
0.64
1.4
1.6
15765.95
16828.97
e6/l
0.06
21
143
11
72
1.53
0.59
1.1
1.1
—
—
—
0
0
23
177
1.31
0.55
1.4
1.4
161.00
253.70
miu/ml
—
10
94
6
38
1.58
0.54
1.0
1.1
145.83
138.80
nmol/l
—
6
38
6
38
1.58
0.54
1.0
1.1
7.32
6.37
ug/l
—
6
33
9
135
0.66
0.52
1.6
1.4
—
—
—
0
0
9
65
1.39
0.50
1.3
1.2
—
—
—
0
0
47
400
1.19
0.49
1.3
1.2
—
—
—
0
0
7
47
1.49
0.47
1.0
1.0
—
—
—
0
0
14
102
1.38
0.47
1.8
1.1
—
—
—
0
0
24
191
1.26
0.47
4.2
3.6
0.82
0.78
nmol/l
0.19
19
160
5
33
1.52
0.41
1.4
1.1
572.60
247.02
iu/ml
—
5
33
41
474
0.86
0.40
1.6
1.7
3.25
3.46
mmol/l
0.59
29
352
98
896
1.11
0.39
1.2
1.4
—
—
—
0
0
11
80
1.38
0.38
1.1
1.1
—
—
—
0
0
25
207
1.21
0.37
1.1
1.2
—
—
—
0
0
6
42
1.43
0.35
1.0
1.0
—
—
—
0
0
6
43
1.40
0.35
1.2
1.1
177.33
224.29
mg/l
—
6
35
6
45
1.34
0.34
1.3
1.1
23.63
43.81
mg/l
—
6
34
22
183
1.21
0.32
1.6
1.4
10.78
7.41
u/l
0.31
13
145
7
53
1.32
0.31
1.9
2.2
—
—
—
0
0
66
603
1.10
0.29
1.5
1.5
—
—
—
0
0
17
139
1.23
0.29
1.3
1.4
—
—
—
0
0
26
299
0.87
0.26
2.7
3.9
83.86
9664.47
u/ml
0.59
21
261
9
75
1.20
0.25
1.3
1.2
—
—
—
0
0
9
75
1.20
0.25
2.7
2.3
—
—
—
0
0
22
254
0.86
0.24
2.0
2.1
—
—
—
0
0
78
729
1.08
0.22
2.8
2.4
13.37
13.71
nmol/l
0.15
65
657
7
91
0.77
0.22
1.3
1.3
0.60
20.37
nmol/l
—
7
86
172
1653
1.05
0.21
3.2
3.2
0.72
0.79
ug/l
0.53
110
1057
0
11
0.00
0.21
0.0
2.7
—
7011.18
—
0
11
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
0
12
0.00
0.21
0.0
3.1
—
14.47
—
0
12
0
13
0.00
0.21
0.0
2.0
—
2.27
—
0
13
6
48
1.25
0.20
3.2
3.7
0.83
0.94
index
—
6
48
19
165
1.16
0.19
1.2
1.3
496.84
482.54
mg/l
0.09
19
156
13
109
1.20
0.18
1.2
1.5
—
—
—
0
0
13
109
1.20
0.18
1.2
1.5
—
—
—
0
0
13
109
1.20
0.18
1.2
1.5
—
—
—
0
0
13
109
1.20
0.18
1.2
1.5
—
—
—
0
0
20
175
1.15
0.18
2.7
2.8
—
—
—
0
0
5
68
0.73
0.17
1.6
1.4
—
—
—
0
0
63
667
0.94
0.15
1.5
1.6
—
—
—
0
0
7
88
0.79
0.14
1.3
1.2
—
—
—
0
0
11
93
1.19
0.14
1.3
1.3
—
—
—
0
0
19
211
0.90
0.13
1.4
1.1
1.54
1.50
g/l
0.37
19
211
35
376
0.93
0.13
5.5
3.7
1.02
1.02
ratio
0.42
30
352
9
109
0.82
0.13
1.9
1.1
—
—
—
0
0
9
110
0.82
0.13
1.9
1.1
—
—
—
0
0
10
85
1.18
0.12
2.3
1.3
—
—
—
0
0
74
769
0.96
0.10
3.4
4.5
4.38
26.81
ug/l
1.42
64
651
5
45
1.11
0.10
1.0
1.0
—
—
—
0
0
13
116
1.12
0.09
2.6
2.8
—
—
—
0
0
19
206
0.92
0.08
7.3
4.6
—
—
—
0
0
5
64
0.78
0.08
1.6
1.1
—
—
—
0
0
10
88
1.14
0.08
1.6
1.4
8.79
6.59
mmol/l
—
10
82
7
65
1.08
0.08
1.9
1.8
—
—
—
0
0
7
67
1.05
0.08
1.7
1.2
—
—
—
0
0
8
78
1.03
0.07
1.4
1.2
—
—
—
0
0
7
85
0.82
0.07
1.3
1.3
—
—
nmol/l
—
0
0
9
100
0.90
0.06
1.7
1.6
—
—
—
0
0
59
575
1.03
0.04
5.3
3.8
—
—
—
0
0
28
270
1.04
0.03
1.8
2.1
—
—
—
0
0
11
118
0.93
0.02
2.0
2.8
—
—
—
0
0
31
319
0.97
0.02
1.0
1.1
—
—
—
0
0
10
93
1.08
0.02
1.4
1.5
—
—
—
0
0
28
274
1.02
0.00
1.7
2.0
—
—
—
0
0
10
96
1.04
0.00
2.3
1.4
—
—
—
0
0
12
116
1.03
0.00
1.5
1.7
97.67
61.27
ug/l
0.90
12
106
28
275
1.02
0.00
1.8
2.0
—
—
—
0
0
28
276
1.01
0.00
1.8
1.9
—
—
—
0
0
12
118
1.02
0.00
2.3
2.9
—
—
—
0
0
17
171
0.99
0.00
1.2
1.1
—
—
—
0
0
21
211
1.00
0.00
2.0
2.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
60.44
—
0
9
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
6.59
—
0
9
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
8
79
1.01
-0.00
1.3
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
9
98
0.92
-0.00
3.9
3.8
288.78
21.52
u/ml
—
9
98
9
90
1.00
-0.00
2.3
2.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
0.52
—
0
5
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
39.14
—
0
7
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
9
96
0.94
-0.00
1.3
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint H7_VASCCILIARY and mortality.

Females

Parameter HR [95% CI] p-value
H7_VASCCILIARY 1.43 [1.22, 1.67] < 0.001
Birth year 0.998 [0.99, 1.01] 0.646

During the follow-up period (1.1.1998 — 31.12.2019), 674 out of 2047 females with H7_VASCCILIARY died.

Males

Parameter HR [95% CI] p-value
H7_VASCCILIARY 1.647 [1.36, 1.99] < 0.001
Birth year 0.986 [0.98, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 628 out of 2837 males with H7_VASCCILIARY died.

Mortality risk

Mortality risk for people of age

years, who have H7_VASCCILIARY.

N-year risk Females Males
1 0.142% 0.259%
5 0.861% 1.779%
10 2.386% 4.403%
15 4.604% 8.327%
20 8.298% 13.714%

Relationships between endpoints

Index endpoint: H7_VASCCILIARY – Hyphaema and other vascular disorders of iris and ciliary body

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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