Retrobulbar neuritis in diseases classified elsewhere

H7_RETROBULBNEURINOTH

optic neuritis: Optic neuritis is inflammation of the optic nerve, the nerve that carries the visual signal from the eye to the brain.The conditionmay cause sudden, reduced vision in the affected eye(s). While the cause of optic neuritis is unknown, it has been associated with autoimmune diseases, infections, multiple sclerosis , drug toxicity and deficiency of vitamin B-12. Vision often returns to normal within 2-3 weeks without treatment. In some cases, corticosteroids are given to speed recovery. If known, the underlying cause should be treated.

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Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

2 out of 7 registries used, show all original rules.

149

4. Check minimum number of events

None

149

5. Include endpoints

None

149

6. Filter based on genotype QC (FinnGen only)

131

Control definitions (FinnGen only)

Control exclude
H7_OPTNERVE

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 604 436 164
Only index persons 579 422 157
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.00
Only index persons 0.01 0.02 0.01
Median age at first event (years)
Whole population 41.59 42.05 40.49
Only index persons 41.30 41.71 40.20

-FinnGen-

Key figures

All Female Male
Number of individuals 131 104 27
Unadjusted period prevalence (%) 0.03 0.04 0.01
Median age at first event (years) 40.13 39.68 41.88

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
140
Matched controls
1400
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G35
ICD-10 Finland
Multiple sclerosis
1617.7
153.6
123
6
H48.1*G35
ICD-10 Finland
Retrobulbar neuritis in multiple sclerosis
+∞
141.9
111
*
109
Kela drug reimbursment
Multiple sclerosis
995.8
132.0
110
5
303
Kela drug reimbursment
Dimethyl fumarate, interferon beta, glatiramer acetate and teriflunomid (Multiple sclerosis)
787.7
122.4
104
5
157
Kela drug reimbursment
Dimethyl fumarate, glatiramer acetate, interferon beta and teriflunomid (Multiple sclerosis)
542.2
105.7
93
5
H46
ICD-10 Finland
Optic neuritis
+∞
103.3
86
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
21.3
76.5
78
78
XCK00
NOMESCO Finland
Perimetry
32.5
72.5
52
25
L03AB07
ATC
interferon beta-1a; parenteral
565.0
69.0
63
*
N86
ICPC
Multiple sclerosis
503.3
64.0
59
*
L03AX13
ATC
glatiramer acetate; parenteral
361.0
50.6
48
*
TAB00
NOMESCO Finland
Lumbar puncture
16.4
49.8
50
46
164
Kela drug reimbursment
Fingolimod
647.2
48.4
45
*
353
Kela drug reimbursment
Cladribine and fingolimod
585.4
44.9
42
*
ZX120
NOMESCO Finland
Intravenous
12.4
41.4
50
60
L04AA27
ATC
[U] fingolimod
+∞
39.5
36
*
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
12.6
36.7
42
46
L03AB08
ATC
interferon beta-1b; parenteral
431.3
34.5
33
*
N04BB01
ATC
amantadine; oral
115.4
33.5
35
*
XKD00
NOMESCO Finland
Uroflowmetry
12.3
33.4
38
41
2AB04, ,
NOMESCO Finland
213.8
33.3
33
*
L04AX07
ATC
dimethyl fumarate; oral
142.6
32.2
33
*
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
38.0
31.0
39
14
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
12.5
30.7
34
35
XA800
NOMESCO Finland
Neuropsychological investigation
11.6
29.9
35
39
Z01.0
ICD-10 Finland
Examination of eyes and vision
7.0
27.7
59
132
G37.9
ICD-10 Finland
Demyelinating disease of central nervous system, unspecified
75.6
27.2
30
5
L04AA31
ATC
[U] teriflunomide
+∞
25.8
24
*
H02AB04
ATC
methylprednisolone; systemic
6.7
24.9
52
113
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
55.2
23.3
27
6
H48.1
ICD-10 Finland
Retrobulbar neuritis in diseases classified elsewhere
+∞
22.5
21
*
XKD06
NOMESCO Finland
Physiologic investigation of micturition
31.4
21.4
28
11
XCW99
NOMESCO Finland
Other investigative procedure of eye
7.5
21.3
36
62
M03BX01
ATC
baclofen; systemic
28.7
21.0
28
12
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
22.1
20.7
30
17
F02.89*G35
ICD-10 Finland
Dementia in multiple sclerosis
+∞
20.3
19
*
G04BD12
ATC
mirabegron; oral
7.4
19.2
32
54
XCD10
NOMESCO Finland
Electrophysiological examination of eye
26.2
19.0
26
12
Z3226
NOMESCO Finland
Physiotherapist
5.2
18.8
53
147
Z3231
NOMESCO Finland
Registered nurse
4.8
18.7
67
226
4AA23, ,
NOMESCO Finland
+∞
18.1
17
*
N07XX09
ATC
[U] dimethyl fumarate
72.6
17.2
19
*
G04BD04
ATC
oxybutynin; oral, transdermal
8.1
15.8
23
33
NA7CG
NOMESCO Finland
Spine and spinal cord extensive MRI examination with high intensity magnet
28.9
15.2
20
8
H48.1*A69.2
ICD-10 Finland
Retrobulbar neuritis in Lyme disease
+∞
14.8
14
*
Z3229
NOMESCO Finland
Other healthcare associate professional
6.6
14.4
26
47
G04BD09
ATC
trospium; oral
34.1
14.3
18
6
R4110
NOMESCO Finland
Physiotherapy
3.9
14.1
64
247
L04AE01
ATC
fingolimod; oral
+∞
13.8
13
*
XF400
NOMESCO Finland
ECG with 12 standard connections
5.0
13.3
34
85
Z2446
NOMESCO Finland
Social worker
6.5
12.9
23
41
Z2445
NOMESCO Finland
Psychologist
7.1
12.9
21
34
NA7DG
NOMESCO Finland
Spine and spinal cord very extensive MRI examination with high intensity magnet
22.7
12.8
18
9
N05CF01
ATC
zopiclone; oral
3.7
12.8
62
248
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
5.6
12.7
27
57
N31.9
ICD-10 Finland
Neuromuscular dysfunction of bladder, unspecified
51.4
12.1
14
*
N03AE01
ATC
clonazepam; systemic
9.4
11.7
24
30
H47.2
ICD-10 Finland
Optic atrophy
+∞
11.6
11
*
R35
ICD-10 Finland
Polyuria
6.2
11.3
21
39
UKC02
NOMESCO Finland
Cystoscopy
4.8
10.8
28
70
TPH04
NOMESCO Finland
Cathetrisation of vein
3.6
10.8
46
166
TKC20
NOMESCO Finland
Catheterisation of bladder
9.5
10.8
22
27
R1250
NOMESCO Finland
Evaluation of functional capability
15.9
10.8
17
12
Z2221
NOMESCO Finland
Medical doctor
3.3
10.8
64
285
ZXD10
NOMESCO Finland
Scheduled procedure
3.2
10.6
69
323
G36.0
ICD-10 Finland
Neuromyelitis optica [Devic]
+∞
10.5
10
*
L04AG12
ATC
ofatumumab; parenteral
+∞
10.5
10
*
N06BA07
ATC
modafinil; oral
35.5
10.5
13
*
NA1CG
NOMESCO Finland
Cervical spine extensive MRI examination with high intensity magnet
20.8
10.5
15
8
R4150
NOMESCO Finland
Neuropsychological rehabilitation
18.5
10.1
15
9
N39.4
ICD-10 Finland
Other specified urinary incontinence
5.1
10.0
23
52
R2110
NOMESCO Finland
Giving the first information
5.1
9.7
22
49
ZXA10
NOMESCO Finland
Bilateral
3.7
9.6
37
124
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
4.0
9.6
32
97
A28
ICPC
Limited function/disability NOS
4.3
9.6
28
77
J01EA01
ATC
trimethoprim; systemic
3.1
9.5
56
245
KCV12
NOMESCO Finland
Urinary bladder endoscopic botulin therapy
+∞
9.5
9
*
L04AX01
ATC
azathioprine; systemic
8.5
9.3
20
27
R4120
NOMESCO Finland
Occupational therapy
4.9
9.2
22
51
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
4.1
9.2
29
84
G04BD08
ATC
solifenacin; oral
8.1
9.1
20
28
R20.2
ICD-10 Finland
Paraesthesia of skin
4.2
9.1
27
75
L04AA40
ATC
cladribine; oral
95.6
8.5
9
*
A02BC02
ATC
pantoprazole; systemic
3.3
8.5
109
718
N99
ICPC
Neurological disease other
35.6
8.2
10
*
H53.1
ICD-10 Finland
Subjective visual disturbances
4.2
8.1
24
66
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
4.8
8.0
19
44
N03AX12
ATC
[U] gabapentin; oral
3.2
7.8
37
141
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
26.7
7.7
10
*
R5110, ,
SPAT
4.6
7.5
19
46
N03AX16
ATC
[U] pregabalin
3.0
7.5
43
182
N30.0
ICD-10 Finland
Acute cystitis
3.0
7.5
40
163
3400A
ICD-9 Finland
Multiple sclerosis[SCLEROSIS MULTIPLEX (DISSEMINATA)]
+∞
7.3
7
*
L04AK02
ATC
teriflunomide; oral
+∞
7.3
7
*
C10AC01
ATC
colestyramine; oral
9.6
7.2
14
16
N32.82
ICD-10 Finland
Instability of the detrusor vesicae muscle
31.8
7.2
9
*
TKC22
NOMESCO Finland
Catheterisation instruction
31.8
7.2
9
*
ZXE10
NOMESCO Finland
More than one and less than three hours
2.6
7.1
61
317
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
4.2
7.1
20
53
N29
ICPC
Neurological sympt/complt other
14.8
7.0
11
8
IAZ97
NOMESCO Finland
Psychiatric consultation in another specialty
10.1
7.0
13
14
NA7BG
NOMESCO Finland
Spine and spinal cord MRI examination with high intensity magnet
42.2
6.8
8
*
R42
ICD-10 Finland
Dizziness and giddiness
2.9
6.8
38
158
H02AB07
ATC
prednisone; oral
3.4
6.7
27
92
G97.0
ICD-10 Finland
Cerebrospinal fluid leak from spinal puncture
13.1
6.7
11
9
L28
ICPC
Limited function/disability (L)
3.1
6.6
31
116
NA2CG
NOMESCO Finland
Thoracal spine extensive MRI examination with high intensity magnet
15.2
6.5
10
7
ZXE00
NOMESCO Finland
One hour or less
2.5
6.5
70
402
G04BD07
ATC
tolterodine; oral
8.8
6.5
13
16
U07
ICPC
Urine symptom/complaint other
3.9
6.4
20
57
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
3.1
6.4
31
118
ZXE15
NOMESCO Finland
Procedure duration 120 to 149 minutes
10.0
6.4
12
13
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
6.3
6.4
16
28
SPAT1229
SPAT
Assessment of need for aid
6.9
6.4
15
24
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
4.2
6.3
18
48
L01BB04
ATC
cladribine; systemic
+∞
6.3
6
*
L04AA52
ATC
[U] ofatumumab; parenteral
+∞
6.3
6
*
N32.83
ICD-10 Finland
Nozzle synergy in the bladder neck
+∞
6.3
6
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.4
6.2
25
85
H53.9
ICD-10 Finland
Visual disturbance, unspecified
6.1
6.2
16
29
K59.00
ICD-10 Finland
Constipation caused by slow bowel passage (SCT)
13.3
6.2
10
8
N28
ICPC
Limited function/disability (N)
13.3
6.2
10
8
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
3.4
6.0
24
81
O99.3
ICD-10 Finland
Mental disorders and diseases of the nervous system complicating pregnancy, childbirth and the puerperium
6.9
6.0
14
22

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
52
22
37.01
76.14
1.2
1.3
—
—
—
0
0
70
157
7.92
33.60
7.8
2.5
5.31
4.00
e6/l
0.28
39
67
109
414
8.37
29.42
17.6
5.6
—
—
—
0
0
32
36
11.23
27.05
1.5
1.3
—
—
—
0
0
89
301
6.37
26.52
10.3
2.5
—
—
estimate
—
0
0
88
296
6.31
26.35
10.5
2.5
0.19
0.33
e6/l
0.58
73
200
28
27
12.71
26.21
1.1
1.6
—
—
—
0
0
129
647
13.65
24.04
21.2
6.2
0.51
0.54
e9/l
0.90
119
567
128
650
12.31
23.10
21.3
6.2
0.03
0.04
e9/l
3.75
118
568
122
594
9.20
22.93
20.5
6.3
9.10
8.27
%
2.87
122
561
129
668
12.85
22.56
21.2
6.2
1.46
2.00
e9/l
5.38
120
603
91
350
5.57
22.31
10.6
2.9
10.60
221.14
e6/l
0.56
75
257
121
594
8.64
22.23
20.6
6.2
3.00
2.82
%
0.40
121
559
102
435
5.95
21.94
12.7
3.6
17.70
94.27
e6/l
0.57
77
272
122
611
8.75
21.68
20.4
6.2
24.97
29.28
%
5.00
122
586
81
290
5.25
21.50
6.4
3.3
—
—
—
0
0
120
595
8.12
21.46
20.8
6.3
0.72
0.68
%
0.33
120
557
128
677
11.39
21.26
21.9
6.5
0.17
0.19
e9/l
0.78
118
604
28
37
9.21
20.76
1.1
1.3
7.50
20.36
e6/l
0.32
16
28
120
605
7.88
20.75
20.4
6.2
60.44
56.74
%
3.50
120
580
51
131
5.55
19.95
1.7
1.4
—
—
—
0
0
27
37
8.80
19.39
1.1
1.4
14.07
171.40
e6/l
0.51
15
30
128
727
9.87
18.17
23.5
10.1
3.48
3.97
e9/l
2.84
118
639
107
560
4.86
15.64
23.3
9.9
0.00
0.00
e9/l
0.68
90
452
104
534
4.68
15.57
6.3
3.1
6.56
6.19
ph
2.09
42
305
24
17
16.75
15.21
1.1
1.5
—
—
—
0
0
82
373
3.89
14.20
5.1
2.8
—
0.00
—
0
5
59
216
3.99
14.05
1.7
1.5
—
—
—
0
0
81
368
3.85
14.00
14.9
6.4
—
—
—
0
0
111
647
4.45
12.78
7.2
3.5
0.00
0.00
estimate
—
10
137
111
655
4.35
12.36
7.3
3.5
0.00
0.00
estimate
-0.00
11
137
27
60
5.34
12.02
1.6
1.2
—
—
—
0
0
19
14
15.48
11.86
1.1
1.2
—
—
—
0
0
110
657
4.15
11.75
7.2
3.6
0.00
0.00
estimate
—
10
130
30
89
4.02
9.25
3.5
1.8
—
—
—
0
0
14
10
15.38
8.90
1.1
1.0
1908.43
1737.80
miu/ml
—
14
10
68
350
2.83
8.39
1.8
1.8
—
—
—
0
0
121
855
4.06
8.30
11.6
4.2
—
—
—
0
0
12
11
11.80
6.94
2.5
1.7
53.36
44.25
%
0.97
12
11
71
415
2.44
6.29
1.9
2.1
—
—
—
0
0
55
305
2.32
5.29
5.9
3.9
7.40
7.40
ph
0.40
39
220
48
257
2.32
4.96
6.6
3.8
—
—
—
0
0
17
52
3.58
4.93
4.4
1.9
—
—
—
0
0
21
75
3.12
4.80
20.3
5.6
—
—
—
0
0
27
114
2.70
4.58
3.5
2.5
28.38
29.02
u/l
0.05
21
95
12
23
5.60
4.57
3.1
3.0
2.17
1.31
index
—
6
13
129
1089
3.35
3.97
36.0
15.4
13.44
13.39
%
0.15
129
1082
140
1307
+∞
3.62
25.3
10.6
25.54
25.62
u/l
0.02
140
1287
14
48
3.13
3.41
8.6
9.2
94.59
94.74
%
0.04
14
48
73
511
1.90
3.41
11.3
6.3
1.21
1.22
mmol/l
0.64
65
440
13
47
2.95
2.90
22.7
2.0
24.46
24.59
mmol/l
0.06
13
47
66
466
1.79
2.85
11.8
5.7
1.21
1.22
mmol/l
0.85
66
437
38
577
0.53
2.79
2.6
2.7
—
—
—
0
0
67
480
1.76
2.72
2.2
2.0
92.66
94.56
pmol/l
0.15
35
257
27
145
2.07
2.65
3.3
2.6
5.95
5.10
umol/l
0.23
22
126
8
197
0.37
2.42
1.0
1.3
—
—
—
0
0
49
330
1.75
2.41
2.4
1.4
2.00
2.21
g/l
0.52
36
210
13
54
2.55
2.27
4.2
1.6
21.85
19.87
s
0.54
13
45
31
194
1.77
1.93
3.2
2.6
57.33
366.12
ng/l
0.76
18
105
8
177
0.42
1.86
1.3
2.0
—
—
—
0
0
20
110
1.95
1.84
21.5
6.0
105.10
105.06
mmol/l
0.01
20
110
7
23
3.15
1.82
40.9
2.2
76.86
61.92
%
—
7
23
131
1212
2.26
1.79
23.9
12.6
139.60
139.77
mmol/l
0.30
131
1187
42
292
1.63
1.78
2.5
1.8
0.51
1.06
mg/l
1.47
32
219
6
18
3.43
1.76
2.0
2.2
—
—
—
0
0
46
329
1.59
1.73
10.8
4.9
—
—
—
0
0
7
25
2.89
1.67
1.1
1.2
—
—
—
0
0
12
56
2.25
1.66
1.3
1.2
—
—
—
0
0
8
32
2.59
1.62
1.0
1.4
—
—
—
0
0
15
78
2.03
1.61
20.1
3.0
0.99
1.77
mmol/l
0.37
15
68
14
248
0.52
1.55
1.2
1.6
—
—
—
0
0
5
15
3.42
1.53
5.4
2.2
—
—
—
0
0
7
27
2.67
1.53
1.6
1.7
—
—
—
0
0
7
27
2.67
1.53
3.6
3.6
61.04
59.31
%
—
7
27
6
21
2.94
1.52
1.0
1.4
—
—
—
0
0
6
22
2.80
1.45
1.3
1.0
—
—
—
0
0
6
22
2.80
1.45
47.3
2.2
78.50
60.51
%
—
6
22
16
89
1.90
1.44
7.7
6.9
4.94
5.08
kpa
0.19
16
84
16
89
1.90
1.44
7.7
6.8
12.76
13.34
kpa
0.18
16
84
9
41
2.28
1.40
1.2
1.1
—
—
—
0
0
53
409
1.48
1.37
16.3
9.0
1.27
1.11
inr
0.98
42
337
15
83
1.90
1.37
20.7
2.8
7.40
7.39
ph
—
5
46
12
61
2.06
1.37
1.0
1.3
—
—
—
0
0
5
17
3.01
1.37
1.0
1.4
—
—
—
0
0
10
48
2.17
1.31
1.5
1.5
—
—
—
0
0
19
293
0.59
1.30
1.2
1.3
1.36
7.53
u/ml
—
7
114
34
458
0.66
1.29
1.1
1.6
—
—
—
0
0
14
79
1.86
1.22
1.5
1.4
—
—
—
0
0
8
38
2.17
1.20
1.3
1.2
—
—
—
0
0
8
39
2.11
1.17
2.3
2.0
—
—
—
0
0
7
139
0.48
1.17
1.6
1.3
—
—
—
0
0
5
20
2.55
1.16
4.4
4.2
4.09
3.88
e9/l
—
5
20
108
1170
0.66
1.16
4.2
4.1
5.75
5.67
mmol/l
0.24
101
1101
45
350
1.42
1.09
6.8
3.0
8.22
8.05
mmol/l
0.08
40
304
12
68
1.84
1.04
1.3
1.8
—
—
—
0
0
9
49
1.89
1.01
32.0
2.3
1.19
1.25
%
—
9
49
9
49
1.89
1.01
32.0
2.2
0.57
0.60
%
—
9
49
0
29
0.00
0.99
0.0
1.0
—
—
—
0
0
140
1371
+∞
0.99
41.7
19.8
135.46
135.34
g/l
0.04
140
1362
0
28
0.00
0.99
0.0
1.1
—
—
—
0
0
140
1370
+∞
0.98
44.4
19.9
40.46
40.61
%
0.14
140
1361
140
1370
+∞
0.98
41.5
19.6
30.55
30.13
pg
2.57
140
1362
7
36
1.99
0.98
1.3
1.7
69.86
34.25
nmol/l
—
7
36
116
1232
0.66
0.98
4.1
4.4
4.81
4.77
mmol/l
0.18
111
1178
140
1369
+∞
0.97
41.4
19.6
91.69
90.33
fl
3.34
140
1361
140
1368
+∞
0.96
41.6
19.7
256.50
262.23
e9/l
0.50
140
1358
9
154
0.56
0.95
1.4
1.4
—
—
—
0
0
116
1229
0.67
0.91
4.0
4.3
1.48
1.50
mmol/l
0.13
110
1172
28
208
1.43
0.86
1.3
1.4
373.33
449.57
titre
—
6
46
125
1179
1.56
0.85
6.8
5.6
1.86
1.73
mu/l
0.48
120
1120
0
25
0.00
0.80
0.0
4.6
—
25.29
—
0
19
21
284
0.69
0.78
1.3
1.8
—
—
—
0
0
8
131
0.59
0.78
1.4
1.3
31.09
21.15
iu/l
—
8
106
13
194
0.64
0.78
1.6
1.6
332.85
456.50
pmol/l
2.62
13
173
9
58
1.59
0.71
2.0
1.8
—
—
—
0
0
18
128
1.47
0.70
1.6
1.2
86.84
143.35
u/ml
—
9
50
14
94
1.54
0.70
1.6
1.4
—
—
—
0
0
8
49
1.67
0.63
1.1
1.1
—
—
—
0
0
60
528
1.24
0.57
2.1
2.0
—
—
—
0
0
14
99
1.46
0.56
7.9
4.6
0.67
0.82
%
—
6
30
6
37
1.65
0.56
1.3
2.5
1.20
1.24
mg/l
—
6
31
13
91
1.47
0.55
8.5
4.7
0.20
0.88
%
—
5
26
134
1304
1.64
0.54
13.3
11.1
—
—
—
0
0
10
66
1.55
0.54
29.3
2.6
5.46
4.60
kpa
—
10
66
44
376
1.25
0.54
2.3
2.5
50.55
57.06
u/l
1.17
44
356
13
92
1.46
0.52
8.5
4.8
0.00
0.13
%
—
5
23
14
101
1.43
0.52
1.6
1.4
—
—
—
0
0
14
101
1.43
0.52
1.6
1.4
—
—
—
0
0
111
1163
0.78
0.51
3.3
3.6
1.14
1.24
mmol/l
1.26
104
1094
7
110
0.62
0.50
1.0
1.8
—
—
—
0
0
14
103
1.40
0.47
1.6
1.4
—
—
—
0
0
5
83
0.59
0.47
1.4
1.5
—
—
—
0
0
5
84
0.58
0.47
1.4
1.6
—
—
—
0
0
14
104
1.38
0.45
1.6
1.4
—
—
—
0
0
12
88
1.40
0.41
3.1
3.3
1.50
1.84
%
1.41
12
82
0
15
0.00
0.41
0.0
1.5
—
—
—
0
0
0
15
0.00
0.41
0.0
15.3
—
1006.80
—
0
15
0
16
0.00
0.41
0.0
1.5
—
—
—
0
0
14
106
1.36
0.41
1.8
2.0
5.81
6.20
ph
—
8
70
0
18
0.00
0.40
0.0
1.9
—
—
—
0
0
20
161
1.28
0.40
1.9
1.3
—
—
—
0
0
0
19
0.00
0.39
0.0
1.3
—
406.00
—
0
19
39
341
1.20
0.38
9.4
3.6
0.00
0.00
estimate
-0.00
11
131
34
294
1.21
0.37
8.2
3.2
75.20
81.07
mg/l
0.05
28
183
14
176
0.77
0.34
1.4
1.2
—
—
—
0
0
6
89
0.66
0.34
1.7
1.4
—
—
—
0
0
56
610
0.86
0.33
2.3
2.6
—
—
estimate
—
0
0
34
298
1.19
0.32
8.7
3.8
9.94
11.63
mg/mmol
0.12
28
179
11
140
0.77
0.30
1.1
1.2
—
—
—
0
0
28
319
0.85
0.29
1.3
1.3
9.60
27.81
iu/ml
—
7
92
17
141
1.23
0.27
3.5
1.5
—
—
—
0
0
121
1238
0.83
0.24
4.6
4.7
2.90
2.84
mmol/l
0.35
114
1183
52
482
1.13
0.23
8.3
3.4
0.00
0.00
estimate
—
10
117
5
41
1.23
0.22
2.2
5.7
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
2.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
11.4
—
0.67
—
0
11
0
10
0.00
0.21
0.0
1.9
—
19.12
—
0
10
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.8
—
36.39
—
0
10
0
10
0.00
0.21
0.0
1.6
—
8.90
—
0
10
0
13
0.00
0.21
0.0
1.6
—
—
—
0
0
0
13
0.00
0.21
0.0
1.6
—
—
—
0
0
0
13
0.00
0.21
0.0
1.6
—
—
—
0
0
0
13
0.00
0.21
0.0
1.6
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
5
69
0.71
0.17
1.0
1.1
1.76
1.59
g/l
—
5
69
7
86
0.80
0.15
2.7
2.6
30.57
28.75
u/ml
—
7
80
10
84
1.21
0.14
2.5
1.6
609.70
339.04
mu/l
—
10
74
9
105
0.85
0.13
1.0
1.1
—
—
—
0
0
31
288
1.10
0.13
8.5
3.3
1.02
1.02
kg/l
0.14
23
189
38
358
1.08
0.12
1.4
1.3
0.61
1.30
u/ml
—
9
104
39
369
1.08
0.11
5.6
3.0
0.00
0.00
estimate
—
10
111
17
155
1.11
0.09
1.6
2.2
—
—
—
0
0
15
165
0.90
0.09
1.7
1.2
—
—
—
0
0
11
97
1.15
0.09
1.0
1.2
—
—
—
0
0
15
137
1.11
0.08
2.3
2.0
394.80
385.52
nmol/l
0.05
15
127
6
71
0.84
0.08
1.0
1.2
0.90
0.85
g/l
—
6
71
7
82
0.85
0.07
1.4
1.2
—
—
—
0
0
54
529
1.03
0.03
1.8
1.8
1.36
1.38
mmol/l
0.06
48
472
15
158
0.94
0.02
1.6
1.9
3.42
3.48
mmol/l
—
10
113
38
373
1.03
0.01
3.2
2.9
16.00
18.81
ng/l
0.25
17
193
42
413
1.02
0.01
2.5
2.1
—
—
—
0
0
14
144
0.97
0.00
3.5
4.0
1.31
1.70
ug/l
0.67
14
134
10
102
0.98
0.00
9.5
3.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
102.63
—
0
8
0
5
0.00
-0.00
0.0
3.2
—
14.50
—
0
5
0
6
0.00
-0.00
0.0
1.2
—
74.87
—
0
6
0
6
0.00
-0.00
0.0
1.8
—
9.87
—
0
6
6
60
1.00
-0.00
7.7
3.2
7.39
7.42
ph
—
6
53
0
5
0.00
-0.00
0.0
1.2
—
0.02
—
0
5
0
6
0.00
-0.00
0.0
1.0
—
470.50
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
73.86
—
0
7
0
6
0.00
-0.00
0.0
1.2
—
26.00
—
0
6
0
9
0.00
-0.00
0.0
1.2
—
92.91
—
0
9
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
3.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
4.0
—
49.10
—
0
5
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
3.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint H7_RETROBULBNEURINOTH and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have H7_RETROBULBNEURINOTH.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: H7_RETROBULBNEURINOTH – Retrobulbar neuritis in diseases classified elsewhere

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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