eye disease: A non-neoplastic or neoplastic disorder that affects the eye. Representative examples include conjunctivitis, glaucoma, cataract, conjunctival squamous cell carcinoma, uveal melanoma, and retinoblastoma. [NCIt:C26767]
Other retinal disorders in diseases classified elsewhere
DOID EFO Endpoint Browser PheWeb
H7_RETINODISINOTH
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
93 |
4. Check minimum number of eventsNone |
93 |
5. Include endpointsNone |
93 |
6. Filter based on genotype QC (FinnGen only) |
80 |
Control definitions (FinnGen only)
- Control exclude
- H7_CHOROIDRETINA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other retinal disorders in diseases classified elsewhere
based on the number of shared cases.
Similar with more cases:
- Other retinal disorders
- Disorders of choroid and retina
- Diseases of the eye and adnexa
- Any operation in hilmo
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 574 | 264 | 305 |
| Only index persons | 475 | 225 | 250 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 73.40 | 75.61 | 71.43 |
| Only index persons | 71.89 | 74.19 | 69.82 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 80 | 25 | 55 |
| Unadjusted period prevalence (%) | 0.02 | 0.01 | 0.03 |
| Median age at first event (years) | 70.54 | 70.43 | 70.59 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 84
- Matched controls
- 840
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H36.8*I70.8
ICD-10 Finland
Atherosclerotic retinopathy
+∞
92.6
71
*
XCK10
NOMESCO Finland
Photography of fundus of eye
14.3
28.0
31
33
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
10.3
25.7
41
71
CKC12
NOMESCO Finland
Photocoagulation of retina
+∞
25.3
23
*
I65.2
ICD-10 Finland
Occlusion and stenosis of carotid artery
43.3
22.3
27
9
Z3229
NOMESCO Finland
Other healthcare associate professional
10.0
19.5
27
38
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
13.4
14.6
26
27
Z2221
NOMESCO Finland
Medical doctor
5.6
13.8
42
128
XCW99
NOMESCO Finland
Other investigative procedure of eye
12.4
13.1
24
26
Z3231
NOMESCO Finland
Registered nurse
5.0
12.2
44
152
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
6.7
12.1
23
45
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
5.3
11.8
33
92
I70.8
ICD-10 Finland
Atherosclerosis of other arteries
138.2
11.7
12
*
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
138.2
11.7
12
*
I25.1
ICD-10 Finland
Atherosclerotic heart disease
4.7
11.5
46
171
PAF14
NOMESCO Finland
Thrombendarterectomy of internal carotid artery
21.5
11.2
16
9
B01AC04
ATC
clopidogrel; oral
4.7
11.1
39
130
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
14.9
11.0
18
15
Z01.0
ICD-10 Finland
Examination of eyes and vision
5.2
10.6
28
74
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
4.2
9.1
34
116
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
16.5
9.1
14
10
XF400
NOMESCO Finland
ECG with 12 standard connections
4.4
9.0
30
94
I70.9
ICD-10 Finland
Generalized and unspecified atherosclerosis
13.7
9.0
15
13
A10AC01
ATC
insulin (human); parenteral
8.1
8.9
20
31
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
11.3
8.7
16
17
R4110
NOMESCO Finland
Physiotherapy
4.0
8.7
39
151
H36.8
ICD-10 Finland
Other retinal disorders in diseases classified elsewhere
+∞
8.5
8
*
PAN14
NOMESCO Finland
Plastic repair of arteries internal carotid artery
37.3
8.3
10
*
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
10.9
7.6
14
15
ZXA00
NOMESCO Finland
Right side
3.7
7.6
36
143
H34.8
ICD-10 Finland
Other retinal vascular occlusions
87.5
7.5
8
*
WX002
NOMESCO Finland
Sedation and analgesia
4.1
7.5
26
83
C10AA01
ATC
simvastatin; oral
3.7
7.5
56
297
H35.0
ICD-10 Finland
Background retinopathy and retinal vascular changes
+∞
7.4
7
*
H3601, E113,
ICD-10 Finland
+∞
7.4
7
*
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
33.2
7.3
9
*
ZXD10
NOMESCO Finland
Scheduled procedure
3.4
7.0
45
214
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
8.0
6.9
15
22
ZXA10
NOMESCO Finland
Bilateral
3.8
6.8
27
94
103
Kela drug reimbursment
Diabetes, insulin-treated
3.3
6.6
39
175
215
Kela drug reimbursment
Diabetes, non-insulin-treated
3.4
6.6
33
134
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
3.9
6.6
24
79
CK2L4
NOMESCO Finland
Wide-field/panoramic imaging of ocular fundus
75.3
6.5
7
*
H36.01
ICD-10 Finland
Diabetic maculopathy
+∞
6.3
6
*
H21.1
ICD-10 Finland
Other vascular disorders of iris and ciliary body
+∞
6.3
6
*
CKC20
NOMESCO Finland
Cryopexy of undetached retina
+∞
6.3
6
*
XCD20
NOMESCO Finland
Photoangiography of eye
+∞
6.3
6
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.2
6.3
52
282
A10AB05
ATC
insulin aspart; parenteral
6.0
6.3
17
34
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
3.4
6.3
30
118
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
6.1
6.1
16
31
ZXE00
NOMESCO Finland
One hour or less
3.1
6.1
43
213
NHQ40
NOMESCO Finland
Amputation of toe
16.6
6.0
9
6
A10AA02, ,
ATC
16.6
6.0
9
6
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
13
15
10.02
6.84
3.3
2.3
194.15
263.47
%
1.33
13
15
37
165
3.22
6.29
5.5
2.5
—
—
—
0
0
21
68
3.78
5.83
20.8
4.6
1.67
2.19
mmol/l
0.30
21
53
13
24
6.20
5.16
2.5
2.3
319.00
397.20
ug/l
0.14
13
24
23
87
3.26
5.00
20.8
7.5
1.23
1.06
mmol/l
1.01
23
79
11
19
6.48
4.62
3.7
2.1
86.73
88.16
%
0.05
11
19
16
51
3.64
4.48
20.2
8.1
24.92
24.84
mmol/l
0.04
16
51
24
100
2.96
4.39
19.0
7.2
104.04
105.06
mmol/l
0.44
24
100
48
286
2.58
4.35
2.9
2.0
94.50
92.99
pmol/l
0.07
22
154
53
333
2.60
4.27
20.8
7.2
1.19
1.21
mmol/l
1.19
48
288
25
118
2.59
3.56
5.7
3.1
0.38
0.68
e6/l
1.00
13
65
9
18
5.46
3.48
1.9
1.9
—
—
—
0
0
23
108
2.56
3.29
6.1
3.2
2.18
0.78
e6/l
0.32
11
58
14
50
3.16
3.27
19.8
10.0
0.62
0.66
%
0.19
14
50
14
50
3.16
3.27
19.8
9.5
1.94
1.38
%
0.33
14
50
45
291
2.18
3.05
7.2
2.8
—
—
estimate
—
0
0
20
91
2.57
3.03
15.0
7.4
5.30
5.06
kpa
0.53
20
85
20
91
2.57
3.03
15.2
7.4
11.22
10.99
kpa
0.09
20
86
41
256
2.18
3.03
3.2
2.4
74.97
75.77
nmol/l
0.06
36
227
7
14
5.35
2.79
1.3
1.7
—
—
—
0
0
7
14
5.35
2.79
1.3
1.7
—
—
—
0
0
10
36
3.01
2.22
1.5
1.3
—
—
—
0
0
5
10
5.24
2.10
1.0
1.4
—
—
—
0
0
49
360
1.87
2.04
15.8
9.6
4.48
4.35
e9/l
0.11
40
307
19
102
2.11
1.96
2.1
1.7
—
—
—
0
0
31
200
1.87
1.92
6.0
3.4
0.39
0.32
e6/l
0.11
24
147
11
47
2.54
1.86
2.2
1.7
—
—
—
0
0
34
228
1.83
1.85
5.8
3.8
44.42
11.74
mg/mmol
0.63
19
151
18
100
2.02
1.69
2.2
1.8
—
—
—
0
0
23
141
1.87
1.64
2.1
1.9
—
—
—
0
0
50
396
1.65
1.39
14.3
5.1
7.61
6.75
mmol/l
1.39
50
375
6
23
2.73
1.39
1.3
1.3
—
—
—
0
0
11
55
2.15
1.34
2.0
1.7
—
—
—
0
0
5
18
2.89
1.30
1.0
1.4
—
—
—
0
0
5
19
2.73
1.23
1.0
1.2
—
—
—
0
0
5
20
2.59
1.17
1.0
1.4
—
—
—
0
0
5
20
2.59
1.17
3.8
1.2
—
—
—
0
0
7
36
2.03
0.99
16.9
2.7
1.11
1.27
%
—
7
36
16
235
0.61
0.98
2.2
1.9
1.37
1.28
mmol/l
0.30
16
188
12
75
1.70
0.80
3.3
4.0
3.02
65.57
ug/l
0.62
12
66
28
219
1.42
0.72
3.9
3.1
2.36
2.35
mmol/l
0.06
28
197
51
451
1.33
0.58
3.5
3.9
14.60
15.02
pmol/l
0.44
43
407
17
127
1.42
0.55
1.8
1.6
675.30
1190.89
nmol/l
—
10
96
62
569
1.34
0.51
38.0
17.9
69.03
76.17
ml/min/173m2
1.36
62
535
51
459
1.28
0.47
4.8
4.3
22.00
13.87
mm/h
1.77
51
422
60
553
1.30
0.44
5.1
4.8
1.65
1.99
mu/l
2.16
54
495
5
31
1.65
0.44
1.6
2.2
—
—
—
0
0
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
24
206
1.23
0.31
5.1
2.9
38.79
33.66
u/l
0.21
24
197
9
76
1.21
0.25
10.3
10.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
47.34
—
0
10
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
6
50
1.22
0.20
35.2
4.1
1.18
1.22
mmol/l
—
6
43
58
553
1.16
0.20
5.5
4.6
1.41
1.29
mmol/l
0.85
52
505
31
337
0.87
0.19
3.0
2.9
—
—
—
0
0
9
77
1.19
0.16
7.1
3.7
—
—
—
0
0
13
149
0.85
0.15
2.5
5.0
1.02
1.02
kg/l
—
7
109
62
601
1.12
0.12
8.1
6.0
2.18
2.61
mmol/l
4.46
56
549
21
196
1.10
0.08
3.1
3.2
0.47
0.71
ug/l
1.14
14
129
35
335
1.08
0.08
4.5
4.2
0.00
0.00
estimate
—
5
74
7
80
0.86
0.07
2.0
1.4
—
—
—
0
0
33
343
0.94
0.06
4.5
5.4
29.37
2.26
ug/l
0.47
28
304
64
629
1.07
0.05
50.9
21.7
139.08
139.64
mmol/l
0.74
64
617
64
630
1.07
0.04
54.6
21.8
4.08
4.02
mmol/l
0.67
64
618
58
590
0.95
0.04
7.1
5.5
7.02
6.08
mmol/l
2.11
50
535
35
341
1.05
0.03
4.5
4.3
0.00
21.95
estimate
—
5
74
29
284
1.03
0.00
5.4
4.4
211.08
40.91
ng/l
0.66
24
211
58
581
0.99
0.00
6.3
5.2
1.20
1.40
mmol/l
3.34
52
533
58
583
0.98
0.00
6.3
5.3
3.86
4.46
mmol/l
5.92
53
537
26
265
0.97
0.00
4.3
4.5
17.70
21.95
%
—
8
131
64
645
0.97
0.00
47.7
23.5
121.56
85.45
umol/l
1.37
64
637
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
5
0.00
-0.00
0.0
4.6
—
1.40
—
0
5
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
6.3
—
819.56
—
0
9
Mortality – FinRegistry
↥Association
Association between endpoint H7_RETINODISINOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_RETINODISINOTH | 2.022 [1.43, 2.87] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.309 |
During the follow-up period (1.1.1998 — 31.12.2019), 112 out of 224 females with H7_RETINODISINOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_RETINODISINOTH | 3.116 [2.09, 4.64] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.013 |
During the follow-up period (1.1.1998 — 31.12.2019), 158 out of 276 males with H7_RETINODISINOTH died.
Mortality risk
Mortality risk for people of age
years, who have H7_RETINODISINOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.201% | 0.653% |
| 5 | 1.355% | 3.505% |
| 10 | 3.207% | 8.552% |
| 15 | 5.726% | 16.384% |
| 20 | 10.189% | 26.337% |
Relationships between endpoints
↥Index endpoint: H7_RETINODISINOTH – Other retinal disorders in diseases classified elsewhere
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data