paralytic strabismus: An ocular deviation caused by a palsy to one or more of the extraocular muscles or nerves supplying them. [database_cross_reference: ORCID:0000-0003-0986-4123][database_cross_reference: ORCID:0000-0003-0986-4123]
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
294 |
4. Check minimum number of eventsNone |
294 |
5. Include endpointsNone |
294 |
6. Filter based on genotype QC (FinnGen only) |
255 |
Control definitions (FinnGen only)
- Control exclude
- H7_OCUMUSCLE
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other or unspecified paralytic strabismus
based on the number of shared cases.
Similar with more cases:
- Paralytic strabismus
- Strabismus
- Disorders of ocular muscles, binocular movement, accommodation and refraction
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2784 | 1425 | 1332 |
| Only index persons | 1919 | 1005 | 914 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.04 | 0.04 |
| Only index persons | 0.04 | 0.04 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 47.92 | 50.73 | 44.72 |
| Only index persons | 40.99 | 43.75 | 37.95 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 255 | 133 | 122 |
| Unadjusted period prevalence (%) | 0.05 | 0.05 | 0.06 |
| Median age at first event (years) | 45.06 | 43.03 | 47.26 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 269
- Matched controls
- 2690
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
3785A
ICD-9 Finland
Strabismus and other disorders of binocular eye movements, Paralytic strabismus
+∞
101.7
91
*
37304
ICD-8 Finland
Strabismus, paralyticus. Paresis nervorum III, IV, VI
+∞
96.9
87
*
H49.9
ICD-10 Finland
Paralytic strabismus, unspecified
+∞
66.5
61
*
H53.2
ICD-10 Finland
Diplopia
21.1
54.5
43
24
H49.8
ICD-10 Finland
Other paralytic strabismus
+∞
40.7
38
*
H49.2
ICD-10 Finland
Sixth [abducent] nerve palsy
+∞
25.4
24
*
H49.0
ICD-10 Finland
Third [oculomotor] nerve palsy
+∞
25.4
24
*
3503
FHL
Single muscle retroposition
+∞
16.8
16
*
XCW99
NOMESCO Finland
Other investigative procedure of eye
4.3
16.6
48
129
H02.4
ICD-10 Finland
Ptosis of eyelid
6.6
12.7
21
34
37300
ICD-8 Finland
Strabismus, Concomitans convergens
+∞
12.6
12
*
H50.2
ICD-10 Finland
Vertical strabismus
136.1
12.5
13
*
CEC00
NOMESCO Finland
Recession of extraocular muscle
+∞
10.5
10
*
H49.1
ICD-10 Finland
Fourth [trochlear] nerve palsy
+∞
10.5
10
*
3505
FHL
Single muscle resection
+∞
9.4
9
*
CEC10
NOMESCO Finland
Recession and resection of extraocular muscle
+∞
9.4
9
*
3507
FHL
Retroposition and resection
+∞
8.4
8
*
CEC60
NOMESCO Finland
Transposition of extraocular muscle with adjustable suture
+∞
8.4
8
*
108
Kela drug reimbursment
Myasthenia gravis
82.3
7.5
8
*
CE2W4
NOMESCO Finland
Eye movement mapping
82.3
7.5
8
*
H49.4
ICD-10 Finland
Progressive external ophthalmoplegia
+∞
7.3
7
*
H50.0
ICD-10 Finland
Convergent concomitant strabismus
+∞
7.3
7
*
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
3.6
6.9
23
68
G70.0
ICD-10 Finland
Myasthenia gravis
41.1
6.8
8
*
XCK00
NOMESCO Finland
Perimetry
3.6
6.4
21
61
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.3
6.4
56
279
78110
ICD-8 Finland
Other symptoms referable to nervous system and special senses, Diplopia
+∞
6.3
6
*
CEW99
NOMESCO Finland
Other operation on extraocular muscle
+∞
6.3
6
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
24
53
4.87
10.47
2.1
1.3
4.53
17.48
e6/l
0.48
19
40
15
17
9.27
7.65
1.3
1.1
—
—
—
0
0
12
11
11.35
6.86
1.3
1.0
—
—
—
0
0
15
21
7.50
6.80
1.3
1.1
—
—
—
0
0
14
20
7.32
6.30
1.3
1.1
—
—
—
0
0
7
5
14.32
4.60
2.0
1.2
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
8
8
10.26
4.55
1.5
1.4
—
—
—
0
0
7
8
8.94
3.79
1.7
1.3
—
—
—
0
0
13
45
2.98
3.07
2.0
1.9
1.41
4.31
iu/l
—
5
16
6
9
6.79
2.88
2.8
1.3
—
—
—
0
0
0
68
0.00
2.64
0.0
1.6
—
—
—
0
0
5
7
7.25
2.56
1.2
1.0
—
—
—
0
0
5
7
7.25
2.56
1.2
1.0
—
—
—
0
0
135
1103
1.45
2.35
6.7
7.2
1.22
1.22
mmol/l
0.31
120
945
0
59
0.00
2.27
0.0
1.4
—
—
—
0
0
52
357
1.57
2.10
1.8
1.7
1174.05
1206.03
nmol/l
0.10
40
277
16
76
2.18
2.07
1.1
2.4
8.92
10.06
g/l
0.91
16
67
123
1008
1.41
2.02
6.4
6.2
1.21
1.22
mmol/l
0.50
113
926
46
316
1.55
1.85
5.5
7.4
103.11
103.75
mmol/l
0.38
46
316
181
1604
1.39
1.76
4.6
4.2
15.20
14.81
pmol/l
1.32
169
1463
14
68
2.12
1.73
1.0
2.6
0.00
0.07
g/l
0.49
14
63
148
1278
1.35
1.65
6.0
5.1
6.57
6.71
mmol/l
0.50
143
1214
5
14
3.62
1.62
1.0
1.1
—
—
—
0
0
24
148
1.68
1.50
9.0
10.7
94.18
93.29
%
0.38
24
148
16
87
1.89
1.49
1.1
2.6
7.27
7.18
g/l
0.08
16
79
16
87
1.89
1.49
1.1
2.6
3.44
3.79
g/l
0.39
16
79
16
87
1.89
1.49
1.1
2.6
4.14
4.26
g/l
0.32
16
79
69
541
1.37
1.41
2.0
2.2
—
—
—
0
0
119
1013
1.31
1.40
2.9
2.7
—
—
estimate
—
0
0
6
23
2.64
1.37
1.3
1.5
-0.52
1.36
mmol/l
—
6
23
17
98
1.78
1.34
5.1
5.1
1.62
1.45
%
0.26
17
86
5
18
2.81
1.29
1.0
1.0
—
—
—
0
0
20
123
1.68
1.28
2.5
2.9
25.74
24.07
mmol/l
1.97
20
123
14
77
1.86
1.28
1.0
3.0
0.00
0.70
g/l
1.20
14
67
6
25
2.43
1.25
1.2
1.4
—
—
—
0
0
38
274
1.45
1.24
5.1
4.7
0.99
1.04
mmol/l
0.91
38
249
11
57
1.97
1.18
1.9
1.4
—
—
—
0
0
88
733
1.30
1.18
2.6
3.4
1081.55
1338.89
ng/l
0.36
75
636
62
495
1.33
1.12
1.9
1.8
0.85
1.33
mg/l
1.31
47
389
7
31
2.29
1.11
2.4
2.8
101.43
106.29
mmol/l
—
7
31
7
31
2.29
1.11
2.4
2.8
1.19
1.19
mmol/l
—
7
31
14
82
1.75
1.07
1.0
2.7
2.81
2.90
g/l
0.15
14
74
25
173
1.49
1.02
7.3
6.0
7.57
9.60
mmol/l
0.79
25
164
8
44
1.84
0.86
1.1
1.3
—
—
—
0
0
8
44
1.84
0.86
1.1
1.3
—
—
—
0
0
178
1655
1.22
0.82
9.8
8.5
83.57
79.56
u/l
0.52
168
1558
0
25
0.00
0.79
0.0
1.9
—
—
—
0
0
0
25
0.00
0.79
0.0
1.9
—
—
—
0
0
0
25
0.00
0.79
0.0
1.9
—
—
—
0
0
134
1220
1.20
0.74
9.8
10.7
5.04
4.14
e9/l
0.88
110
1060
16
109
1.50
0.72
1.5
1.3
—
—
—
0
0
13
85
1.56
0.70
1.2
2.0
0.75
1.69
ug/l
0.68
13
74
9
59
1.54
0.69
1.7
1.3
—
—
—
0
0
28
215
1.34
0.68
9.2
9.0
118.21
120.81
g/l
0.21
28
207
50
416
1.25
0.68
3.6
4.0
178.41
303.48
ng/l
0.29
41
325
109
981
1.19
0.67
2.2
2.1
97.63
96.62
pmol/l
0.08
57
504
54
454
1.24
0.67
1.7
1.8
425.80
441.46
pmol/l
0.22
45
383
47
389
1.25
0.67
2.7
2.8
2.26
1.00
e6/l
1.86
26
202
5
28
1.80
0.66
1.0
1.4
—
—
—
0
0
109
983
1.18
0.65
2.5
2.4
76.61
76.15
nmol/l
0.06
96
883
5
29
1.74
0.64
1.0
1.7
14.35
20.42
ug/l
—
5
29
153
1423
1.17
0.63
4.6
3.4
69.04
49.54
u/l
0.58
142
1338
10
63
1.61
0.62
2.1
1.4
—
—
—
0
0
5
30
1.68
0.61
2.0
2.0
—
—
—
0
0
5
30
1.68
0.61
1.0
1.1
—
—
—
0
0
73
639
1.20
0.61
3.2
3.1
0.32
0.49
e6/l
0.52
59
460
18
131
1.40
0.61
2.4
2.5
0.59
0.62
%
0.15
18
131
85
755
1.18
0.60
3.3
3.4
2.36
2.36
mmol/l
0.01
77
674
32
257
1.28
0.58
8.4
8.2
11.82
11.95
kpa
0.06
32
245
32
257
1.28
0.58
8.4
8.3
4.89
5.09
kpa
0.66
32
244
50
425
1.22
0.57
3.7
2.8
2.44
2.46
mmol/l
0.47
44
380
43
361
1.23
0.55
2.8
3.0
2.68
1.79
e6/l
0.53
22
177
14
192
0.71
0.54
2.4
1.9
—
—
—
0
0
169
1595
1.16
0.54
4.4
4.3
13.21
11.74
mm/h
0.71
163
1481
6
97
0.61
0.53
1.0
1.4
—
—
—
0
0
10
144
0.68
0.50
1.8
1.9
3.96
3.60
mmol/l
—
10
106
22
172
1.30
0.50
1.2
1.5
—
—
—
0
0
79
875
0.86
0.49
1.9
1.9
1.29
1.35
mmol/l
0.34
67
720
15
111
1.37
0.48
7.4
10.4
14.25
15.73
%
1.02
15
102
200
1920
1.16
0.47
6.2
5.2
1.91
1.93
mu/l
0.08
190
1757
16
120
1.35
0.47
1.4
1.2
271.55
146.41
u/ml
—
6
49
35
293
1.22
0.47
1.4
1.9
—
—
—
0
0
73
654
1.16
0.47
1.7
1.7
20.43
21.27
nmol/l
0.20
63
536
6
94
0.63
0.43
4.0
3.3
19.17
2234.99
u/ml
—
6
80
0
16
0.00
0.41
0.0
1.5
—
—
—
0
0
0
16
0.00
0.41
0.0
1.5
—
—
—
0
0
0
17
0.00
0.41
0.0
1.8
—
557.06
—
0
17
23
280
0.80
0.41
1.8
1.4
—
—
—
0
0
9
66
1.38
0.39
1.2
1.4
—
8.09
—
0
15
65
586
1.14
0.39
2.4
2.8
321.53
345.58
umol/l
0.95
60
503
9
67
1.36
0.38
1.0
1.7
—
—
—
0
0
33
282
1.19
0.37
1.5
2.0
—
—
—
0
0
81
744
1.13
0.36
5.1
3.3
30.21
30.70
u/l
0.09
76
698
61
550
1.14
0.36
2.2
2.1
3.36
3.15
mg/l
0.17
55
470
9
71
1.28
0.36
3.8
1.7
—
—
—
0
0
95
882
1.12
0.36
4.5
4.0
33.23
34.22
ng/l
0.05
74
638
6
44
1.37
0.34
1.0
1.2
—
—
—
0
0
11
143
0.76
0.33
3.2
2.9
282.82
173.42
ng/l
0.22
11
130
21
174
1.22
0.32
3.5
3.0
71.18
62.57
ml/min/173m2
0.36
11
72
7
57
1.23
0.29
1.1
1.3
—
—
—
0
0
10
76
1.33
0.28
1.3
1.9
—
—
—
0
0
26
298
0.86
0.26
6.2
4.8
31.00
31.48
%
0.08
19
194
53
578
0.90
0.26
4.3
4.7
22.71
21.15
%
0.25
24
282
15
181
0.82
0.26
1.3
1.5
—
—
—
0
0
14
170
0.81
0.26
2.0
1.8
—
—
—
0
0
45
408
1.12
0.26
1.3
1.3
19.69
29.72
iu/ml
0.49
16
119
5
39
1.29
0.23
1.2
1.1
—
19.80
—
0
15
38
344
1.12
0.22
2.5
2.1
2.24
2.32
g/l
0.41
33
314
0
11
0.00
0.21
0.0
2.3
—
—
—
0
0
0
11
0.00
0.21
0.0
2.3
—
—
—
0
0
0
10
0.00
0.21
0.0
2.7
—
4.60
—
0
10
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
2.7
—
10.56
—
0
10
8
105
0.75
0.21
1.1
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
2.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
2.2
—
—
—
0
0
0
13
0.00
0.21
0.0
2.2
—
—
—
0
0
0
13
0.00
0.21
0.0
2.2
—
—
—
0
0
0
13
0.00
0.21
0.0
2.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
41
444
0.91
0.18
3.5
3.2
0.55
0.72
ug/l
1.55
26
282
18
205
0.87
0.18
4.1
2.6
29.06
35.59
u/l
0.52
18
169
25
224
1.13
0.18
2.4
3.5
—
—
—
0
0
7
61
1.15
0.17
1.3
1.2
—
—
—
0
0
43
399
1.09
0.17
1.5
2.0
—
—
—
0
0
5
69
0.72
0.17
1.0
1.4
—
—
—
0
0
70
736
0.93
0.16
5.0
5.4
2.34
2.45
ug/l
0.07
62
657
6
76
0.78
0.16
1.2
1.1
1.68
1.52
g/l
—
6
76
6
78
0.76
0.16
1.2
4.4
41.30
53.86
mg/l
—
6
66
6
78
0.76
0.16
1.2
4.4
27.30
28.77
mg/l
—
6
66
78
746
1.06
0.15
4.6
3.9
8.26
9.27
mg/mmol
0.08
50
465
7
87
0.80
0.15
1.3
2.1
—
—
—
0
0
10
84
1.20
0.14
3.6
1.8
—
—
—
0
0
67
640
1.06
0.13
4.7
4.0
0.25
0.01
estimate
0.46
24
220
112
1152
0.95
0.12
5.2
3.9
0.00
0.00
estimate
-0.00
27
243
5
45
1.11
0.10
1.8
1.3
316.00
280.68
u/ml
—
5
25
5
45
1.11
0.10
7.0
2.2
6.72
6.26
pmol/l
—
5
45
40
380
1.06
0.09
1.4
1.3
3.54
10.88
u/ml
1.13
17
132
203
2053
0.95
0.09
5.3
5.0
1.43
1.46
mmol/l
0.52
191
1887
5
48
1.04
0.09
1.8
1.3
—
—
—
0
0
199
1967
1.04
0.09
4.5
4.3
1.32
1.31
mmol/l
0.10
185
1801
6
55
1.09
0.09
1.3
1.2
—
—
—
0
0
6
57
1.05
0.08
1.3
1.1
—
2.67
—
0
10
6
57
1.05
0.08
1.0
1.3
—
1.00
—
0
6
5
61
0.82
0.08
1.0
1.4
—
—
—
0
0
201
2031
0.96
0.08
5.6
5.1
6.03
6.03
mmol/l
0.00
186
1855
8
74
1.08
0.07
1.0
1.2
—
—
—
0
0
124
1262
0.97
0.07
2.7
3.0
—
—
—
0
0
199
2007
0.97
0.06
18.0
15.9
80.74
80.20
ml/min/173m2
0.15
188
1862
197
1983
0.98
0.04
7.6
6.4
39.33
39.75
mmol/mol
0.33
186
1856
205
2062
0.98
0.03
5.3
5.1
4.49
4.61
mmol/l
1.09
193
1906
50
489
1.03
0.03
1.4
1.3
0.64
1.46
u/ml
1.02
18
130
87
882
0.98
0.03
5.0
3.9
0.00
0.02
estimate
0.78
22
211
206
2071
0.98
0.03
21.3
16.6
24.98
24.26
mg/l
0.12
179
1711
26
251
1.04
0.02
6.7
7.9
—
—
—
0
0
15
142
1.06
0.02
1.9
1.7
—
—
—
0
0
10
93
1.08
0.02
3.0
2.5
—
—
—
0
0
210
2094
1.01
0.00
6.3
5.8
2.63
2.69
mmol/l
0.48
199
1933
13
129
1.01
0.00
10.2
8.8
25.98
24.47
mmol/l
0.76
13
129
50
499
1.00
0.00
4.7
4.2
1.02
1.02
kg/l
0.13
31
329
64
641
1.00
0.00
4.7
3.4
0.05
0.00
estimate
0.48
19
192
224
2243
0.99
0.00
29.7
24.9
255.40
248.60
e9/l
0.89
217
2200
218
2183
0.99
0.00
14.5
12.4
28.68
26.43
u/l
0.92
212
2125
39
385
1.02
0.00
1.6
1.5
—
—
—
0
0
116
1163
1.00
0.00
5.1
4.0
0.00
6.63
estimate
0.50
28
245
224
2244
0.99
0.00
29.7
24.8
4.47
4.49
e12/l
0.19
216
2191
8
79
1.01
0.00
1.1
1.2
0.83
0.90
g/l
—
8
79
0
9
0.00
0.00
0.0
5.2
—
211.00
—
0
9
0
9
0.00
0.00
0.0
7.9
—
—
—
0
0
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
4.1
—
45.41
—
0
7
118
1180
1.00
-0.00
5.2
4.0
0.00
0.02
estimate
0.50
28
227
0
6
0.00
-0.00
0.0
3.8
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
5
57
0.87
-0.00
1.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
0.20
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_PARASTRANAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_PARASTRANAS | 1.516 [1.09, 2.11] | 0.013 |
| Birth year | 0.989 [0.98, 1.0] | 0.017 |
During the follow-up period (1.1.1998 — 31.12.2019), 71 out of 277 females with H7_PARASTRANAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_PARASTRANAS | 1.878 [1.32, 2.67] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 75 out of 298 males with H7_PARASTRANAS died.
Mortality risk
Mortality risk for people of age
years, who have H7_PARASTRANAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.103% | 0.306% |
| 5 | 0.822% | 1.925% |
| 10 | 1.879% | 5.128% |
| 15 | 3.335% | 9.938% |
| 20 | 6.096% | 16.04% |
Relationships between endpoints
↥Index endpoint: H7_PARASTRANAS – Other or unspecified paralytic strabismus
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data