No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
187 |
4. Check minimum number of eventsNone |
187 |
5. Include endpointsNone |
187 |
6. Filter based on genotype QC (FinnGen only) |
166 |
Control definitions (FinnGen only)
- Control exclude
- H7_VISUALDISTBLIND
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H54
- Name in latin
- Amblyopia non specificata unius oculi
Similar endpoints
↥List of similar endpoints to
Moderate visual impairment, monocular
based on the number of shared cases.
Similar with more cases:
- Visual impairment including blindness (binocular or monocular)
- Visual disturbances and blindness
- Diseases of the eye and adnexa
- Any prescribed medicine buy
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 987 | 543 | 435 |
| Only index persons | 925 | 517 | 408 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.02 | 0.01 |
| Only index persons | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 56.95 | 56.64 | 57.61 |
| Only index persons | 57.76 | 57.48 | 58.11 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 166 | 95 | 71 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | 62.14 | 58.52 | 66.98 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 178
- Matched controls
- 1780
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H54.6
ICD-10 Finland
Moderate visual impairment, monocular
+∞
257.5
178
*
H53.1
ICD-10 Finland
Subjective visual disturbances
32.0
58.5
40
16
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
6.4
23.9
47
94
XCW99
NOMESCO Finland
Other investigative procedure of eye
6.2
21.2
42
84
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.5
19.7
66
206
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
7.2
17.3
28
45
XCK00
NOMESCO Finland
Perimetry
6.9
15.6
26
43
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
54.2
13.1
15
*
WX140
NOMESCO Finland
Parabulbar anesthesy
5.8
12.6
25
49
AA1AD
NOMESCO Finland
CT of head and brain
3.0
11.0
71
323
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
10.2
10.9
21
23
Z96.1
ICD-10 Finland
Presence of intraocular lens
3.6
10.8
42
140
H53.4
ICD-10 Finland
Visual field defects
116.6
10.5
11
*
H34.1
ICD-10 Finland
Central retinal artery occlusion
105.4
9.5
10
*
XCH00
NOMESCO Finland
Eye pressure measurement
4.8
7.6
18
41
S01ED51
ATC
timolol, combinations; ophthalmic
4.0
7.6
23
64
F05
ICPC
Visual disturbance other
8.1
7.1
15
20
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
2.4
6.9
71
390
H26.4
ICD-10 Finland
After-cataract
3.3
6.9
28
95
R42
ICD-10 Finland
Dizziness and giddiness
2.5
6.8
52
250
H46
ICD-10 Finland
Optic neuritis
23.6
6.7
9
*
R51.80
ICD-10 Finland
Headache
2.7
6.5
41
179
H40.0
ICD-10 Finland
Glaucoma suspect
3.5
6.1
22
69
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
2.2
6.0
72
418
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
57
244
2.97
9.67
1.9
2.1
30.28
29.10
s
0.90
57
239
110
769
2.13
5.54
10.0
7.2
1.22
1.21
mmol/l
0.29
100
679
56
313
2.15
4.99
6.4
3.3
2368.14
394.00
ng/l
0.39
44
244
98
674
2.01
4.95
4.7
5.1
35.56
35.88
g/l
0.22
91
644
101
703
2.01
4.93
2.5
2.6
78.84
76.62
nmol/l
0.29
89
640
144
1148
2.33
4.81
5.4
4.3
13.40
12.07
mm/h
0.45
131
1073
146
1187
2.28
4.39
9.9
8.1
84.90
78.50
u/l
0.82
137
1113
143
1172
2.12
3.91
4.7
4.3
14.53
14.71
pmol/l
0.44
129
1074
15
49
3.25
3.91
1.5
1.2
—
—
—
0
0
45
256
2.01
3.73
1.6
1.7
1038.12
1192.29
nmol/l
0.65
34
194
40
220
2.06
3.62
10.5
6.8
104.80
104.43
mmol/l
0.19
40
220
9
17
5.51
3.56
1.3
1.1
—
—
—
0
0
9
17
5.51
3.56
1.3
1.1
—
—
—
0
0
17
67
2.70
3.23
3.0
4.3
1.54
1.63
%
0.20
17
62
20
86
2.49
3.21
1.8
1.5
—
—
—
0
0
70
481
1.75
3.16
3.3
3.3
1086.92
1244.52
ng/l
0.13
57
418
55
354
1.80
3.09
1.8
1.7
1.09
1.28
mg/l
0.28
40
278
115
912
1.74
3.06
9.6
10.3
4.15
4.11
e9/l
0.08
100
802
30
160
2.05
2.93
2.7
2.0
345.72
381.34
nmol/l
0.51
25
149
161
1427
2.34
2.92
6.4
5.2
1.82
1.88
mu/l
0.34
155
1319
81
593
1.67
2.83
4.7
3.9
30.62
45.58
ng/l
0.61
56
419
7
15
4.81
2.62
1.4
1.1
—
—
—
0
0
8
20
4.14
2.60
8.3
3.0
—
—
—
0
0
46
295
1.75
2.58
1.7
1.8
409.07
459.75
pmol/l
0.80
40
251
159
1421
2.11
2.51
7.7
6.2
39.08
39.03
mmol/mol
0.02
151
1352
6
12
5.13
2.42
1.7
1.2
1.95
1.70
mmol/l
—
6
12
167
1527
2.52
2.40
24.4
15.0
20.85
23.47
mg/l
0.42
144
1260
5
8
6.39
2.38
1.0
1.0
—
—
—
0
0
114
939
1.60
2.29
7.9
4.6
6.64
6.58
mmol/l
0.13
107
876
7
18
4.00
2.27
1.0
1.6
—
—
—
0
0
57
400
1.63
2.26
1.3
1.3
2.42
2.35
u/ml
0.01
20
102
87
678
1.55
2.20
2.3
2.0
86.42
96.17
pmol/l
2.03
52
366
9
30
3.10
2.18
1.4
1.3
—
—
—
0
0
9
30
3.10
2.18
1.4
1.3
—
—
—
0
0
12
49
2.55
2.15
1.7
2.8
196.42
184.76
%
0.15
12
49
56
400
1.58
2.05
2.4
2.2
3.29
2.84
mg/l
0.41
47
354
16
77
2.18
2.04
3.1
3.3
1.02
1.02
ratio
0.91
16
71
20
106
2.00
2.00
2.2
1.5
—
—
—
0
0
88
700
1.51
1.96
9.5
6.6
1.22
1.21
mmol/l
0.60
81
653
41
274
1.64
1.95
3.2
3.3
2.07
1.95
e6/l
0.04
24
138
5
12
4.25
1.83
2.2
1.3
109.20
114.33
pmol/l
—
5
12
93
757
1.48
1.80
2.7
3.0
137.21
116.52
ug/l
0.43
86
712
38
255
1.62
1.78
2.3
1.8
—
—
—
0
0
6
18
3.41
1.76
1.0
1.1
—
—
—
0
0
62
474
1.47
1.61
3.8
3.5
0.36
0.34
e6/l
0.03
49
343
90
741
1.43
1.58
3.1
2.7
—
—
estimate
—
0
0
8
33
2.49
1.55
2.5
6.2
—
136.80
—
0
5
15
79
1.98
1.54
1.5
1.3
—
—
—
0
0
111
952
1.44
1.54
2.9
3.2
—
—
—
0
0
17
94
1.89
1.53
3.2
4.1
3.00
1.55
mmol/l
—
9
76
120
1045
1.46
1.53
4.2
3.4
55.42
44.33
u/l
0.90
110
989
6
21
2.92
1.52
2.5
2.9
1.19
1.19
mmol/l
—
6
21
6
21
2.92
1.52
2.5
2.9
104.67
105.67
mmol/l
—
6
21
10
45
2.29
1.49
1.1
1.2
—
15.11
—
0
7
27
174
1.65
1.48
2.6
4.6
17.04
8.06
ug/l
0.26
20
145
7
29
2.47
1.40
1.0
3.3
6.23
12.18
pmol/l
—
7
29
50
377
1.45
1.38
2.5
2.3
—
—
—
0
0
158
1469
1.67
1.35
23.4
14.9
83.10
81.45
ml/min/173m2
0.49
152
1347
6
24
2.55
1.31
1.3
1.3
—
—
—
0
0
27
182
1.57
1.25
15.6
7.4
-0.18
1.05
mmol/l
0.73
21
157
10
49
2.10
1.24
2.1
1.7
—
—
—
0
0
40
295
1.46
1.23
3.4
3.2
0.58
0.79
e6/l
0.49
23
157
22
142
1.63
1.21
1.6
1.4
—
—
—
0
0
27
184
1.55
1.20
2.5
1.7
—
—
—
0
0
28
193
1.53
1.18
2.4
1.6
—
—
—
0
0
7
31
2.31
1.11
1.1
1.5
—
—
—
0
0
5
22
2.31
1.04
1.0
1.5
—
—
—
0
0
161
1523
1.60
1.03
6.1
5.8
2.62
2.71
mmol/l
0.56
151
1432
159
1501
1.56
1.01
5.5
5.0
1.38
1.47
mmol/l
1.68
150
1401
10
54
1.90
0.98
1.9
1.8
—
—
—
0
0
9
51
1.80
0.96
2.0
1.9
—
—
—
0
0
7
37
1.93
0.95
1.3
1.4
—
—
—
0
0
5
102
0.48
0.92
1.0
1.1
—
—
—
0
0
10
58
1.77
0.81
1.7
3.3
—
—
—
0
0
97
868
1.26
0.78
4.6
3.8
0.00
0.00
estimate
-0.00
25
177
57
479
1.28
0.77
4.2
3.2
0.00
0.17
estimate
0.50
20
150
167
1609
1.61
0.76
16.2
11.8
24.84
26.28
u/l
0.64
161
1560
62
527
1.27
0.76
3.4
3.5
2.34
2.35
mmol/l
0.11
53
480
158
1507
1.43
0.75
5.6
5.1
4.46
4.62
mmol/l
0.93
150
1415
151
1431
1.36
0.74
4.7
4.2
1.31
1.27
mmol/l
0.26
141
1325
5
27
1.88
0.69
1.0
1.1
—
—
—
0
0
7
44
1.61
0.66
1.3
1.2
—
—
—
0
0
7
44
1.61
0.66
1.1
1.1
—
—
—
0
0
137
1290
1.27
0.64
31.4
20.1
331.23
332.11
g/l
0.56
137
1285
49
416
1.25
0.60
2.9
3.0
355.21
347.58
umol/l
0.21
42
367
94
855
1.21
0.59
4.7
3.8
0.00
0.00
estimate
-0.00
24
176
8
54
1.50
0.58
1.3
1.6
—
—
—
0
0
59
514
1.22
0.57
4.2
3.8
4.35
9.97
mg/mmol
1.80
39
319
20
151
1.37
0.57
3.8
3.3
—
—
—
0
0
6
37
1.64
0.56
1.3
1.4
—
—
—
0
0
37
309
1.25
0.53
3.9
3.1
0.60
0.76
ug/l
1.22
26
210
13
92
1.45
0.52
2.3
3.4
0.68
0.63
%
0.40
13
92
21
163
1.33
0.51
8.2
7.3
—
—
—
0
0
16
119
1.38
0.50
20.9
8.1
23.39
25.09
mmol/l
0.65
16
119
36
302
1.24
0.49
2.5
3.0
2.46
2.44
mmol/l
0.28
31
266
7
47
1.51
0.48
1.4
1.5
—
—
—
0
0
34
285
1.24
0.47
1.4
1.3
4.26
13.46
u/ml
1.01
12
120
38
323
1.22
0.47
1.5
1.6
—
—
—
0
0
13
95
1.40
0.45
4.8
3.7
4.38
4.44
pmol/l
0.09
13
86
95
880
1.17
0.45
4.7
3.8
0.00
1.78
estimate
0.50
23
169
13
96
1.38
0.43
2.3
3.4
1.35
1.29
%
0.06
13
96
0
16
0.00
0.41
0.0
1.6
—
—
—
0
0
57
511
1.17
0.40
6.4
5.5
2.94
2.66
ug/l
0.10
52
458
71
650
1.15
0.38
4.8
3.6
0.00
0.01
estimate
0.50
19
150
6
41
1.48
0.36
2.5
1.4
—
—
—
0
0
50
447
1.16
0.36
1.6
1.7
17.21
20.33
nmol/l
1.48
44
384
6
42
1.44
0.36
1.0
1.3
—
20.50
—
0
7
18
145
1.27
0.35
1.9
2.4
0.16
0.15
e6/l
0.05
18
137
6
44
1.38
0.35
1.0
1.2
—
5.86
—
0
5
150
1455
1.20
0.33
6.2
5.0
6.05
5.93
mmol/l
0.58
142
1355
7
53
1.33
0.31
1.1
1.3
—
10.47
—
0
10
44
398
1.14
0.27
5.4
4.9
20.96
21.75
%
0.14
22
195
9
74
1.23
0.25
2.1
1.8
—
—
—
0
0
9
75
1.21
0.25
1.2
1.3
—
—
—
0
0
8
105
0.75
0.21
4.8
4.2
24.75
24.34
mmol/l
—
8
105
0
11
0.00
0.21
0.0
1.3
—
10.72
—
0
5
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.8
—
—
—
0
0
0
12
0.00
0.21
0.0
4.5
—
197.25
—
0
12
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
6
49
1.23
0.20
1.2
1.3
—
—
—
0
0
11
90
1.24
0.19
2.2
1.9
—
—
—
0
0
6
51
1.18
0.19
2.0
1.5
—
—
—
0
0
6
53
1.14
0.19
2.0
1.5
—
—
—
0
0
65
685
0.92
0.18
2.1
2.0
1.47
1.34
mmol/l
0.65
57
581
34
312
1.11
0.17
1.4
1.4
18.40
33.31
iu/ml
—
8
101
18
158
1.15
0.17
1.9
1.7
—
—
—
0
0
20
178
1.14
0.16
2.3
1.9
—
—
—
0
0
11
128
0.85
0.14
2.5
2.5
55.00
66.91
ml/min/173m2
—
5
54
5
48
1.04
0.09
1.2
1.4
—
—
—
0
0
6
55
1.09
0.09
1.2
1.1
0.73
0.87
g/l
—
6
55
5
61
0.81
0.08
1.6
2.1
0.52
1.16
g/l
—
5
55
46
478
0.95
0.08
4.7
3.8
0.00
0.00
estimate
-0.00
24
164
19
202
0.93
0.05
5.6
4.9
32.07
31.65
%
0.07
14
134
39
380
1.03
0.03
5.7
3.7
1.02
1.02
kg/l
1.04
30
249
12
128
0.93
0.02
1.8
3.1
69.31
67.40
g/l
0.45
12
119
24
235
1.02
0.00
1.3
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
8.13
—
0
6
5
57
0.87
-0.00
1.2
5.0
17.88
28.29
mg/l
—
5
48
5
59
0.84
-0.00
1.4
1.7
10.58
10.23
g/l
—
5
54
5
57
0.87
-0.00
1.2
5.0
21.50
148.38
mg/l
—
5
48
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
22.68
—
0
5
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
5
54
0.92
-0.00
1.2
1.0
1.63
1.58
g/l
—
5
54
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
54
0.92
-0.00
1.2
4.0
1.27
1.98
ratio
—
5
28
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
3.8
—
43.47
—
0
8
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_MODVISIMPMONOC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_MODVISIMPMONOC | 1.208 [0.75, 1.94] | 0.434 |
| Birth year | 0.997 [0.99, 1.01] | 0.49 |
During the follow-up period (1.1.1998 — 31.12.2019), 59 out of 447 females with H7_MODVISIMPMONOC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_MODVISIMPMONOC | 1.728 [1.06, 2.82] | 0.029 |
| Birth year | 0.99 [0.98, 1.0] | 0.028 |
During the follow-up period (1.1.1998 — 31.12.2019), 70 out of 356 males with H7_MODVISIMPMONOC died.
Mortality risk
Mortality risk for people of age
years, who have H7_MODVISIMPMONOC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.114% | 0.353% |
| 5 | 0.775% | 2.414% |
| 10 | 1.96% | 5.792% |
| 15 | 3.568% | 10.211% |
| 20 | 6.214% | 16.751% |
Relationships between endpoints
↥Index endpoint: H7_MODVISIMPMONOC – Moderate visual impairment, monocular
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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