Juvenile Open Angle Glaucoma

H7_GLAUCOMA_JOAG

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Pre-conditions: 4<=EVENT_AGE<=40

Registry filters:

0 out of 7 registries used, show all original rules.

0

4. Check minimum number of events

None

0

5. Include endpoints

233

6. Filter based on genotype QC (FinnGen only)

212

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF6

Case counts by codes

FinnGen case counts by registry codes:

No data for upset plot.

No data for upset table.

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1785 745 1023
Only index persons 1675 714 961
Unadjusted period prevalence (%)
Whole population 0.03 0.02 0.03
Only index persons 0.03 0.03 0.04
Median age at first event (years)
Whole population 34.05 34.02 34.02
Only index persons 33.98 34.03 33.95

-FinnGen-

Key figures

All Female Male
Number of individuals 212 113 99
Unadjusted period prevalence (%) 0.04 0.04 0.05
Median age at first event (years) 34.96 34.61 35.37

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
216
Matched controls
2160
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
207.8
308.2
161
30
114
Kela drug reimbursment
Glaucoma
266.9
307.7
188
53
S01ED51
ATC
timolol, combinations; ophthalmic
63.9
209.0
136
56
S01EE01
ATC
latanoprost; ophthalmic
71.4
204.5
124
40
S01ED01
ATC
timolol; ophthalmic
94.6
189.9
104
21
S01EA05
ATC
brimonidine; ophthalmic
91.5
143.1
77
13
XCK00
NOMESCO Finland
Perimetry
30.6
125.7
96
55
S01EC04
ATC
brinzolamide; ophthalmic
53.1
122.7
74
21
H40.0
ICD-10 Finland
Glaucoma suspect
27.3
111.9
88
53
S01EC01
ATC
acetazolamide; systemic
57.7
111.1
65
16
S01EE05
ATC
tafluprost; ophthalmic
42.0
85.8
54
17
S01EE03
ATC
bimatoprost; ophthalmic
61.4
84.2
48
10
XCW99
NOMESCO Finland
Other investigative procedure of eye
12.9
72.3
89
111
CHD05
NOMESCO Finland
Selective lasertrabeculoplasty
23.8
65.0
50
27
S01EX03, ,
ATC
281.3
62.7
61
*
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
22.0
59.3
47
27
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
11.2
58.4
76
100
XCH00
NOMESCO Finland
Eye pressure measurement
15.6
54.2
52
43
XCK10
NOMESCO Finland
Photography of fundus of eye
10.3
53.7
74
104
37510
ICD-8 Finland
Glaucoma, Chronicum simplex
+∞
51.1
47
*
S01EC03
ATC
dorzolamide; ophthalmic
132.7
49.2
51
5
Z01.0
ICD-10 Finland
Examination of eyes and vision
7.0
43.2
95
219
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
88.8
39.6
43
6
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
10.8
39.1
47
54
3651A
ICD-9 Finland
Glaucoma, Open-angle glaucoma[GLAUCOMA SIMPLEX (AVOKULMA)]
+∞
38.7
36
*
Z96.1
ICD-10 Finland
Presence of intraocular lens
7.9
35.7
58
96
H40.9
ICD-10 Finland
Glaucoma, unspecified
111.1
35.0
37
*
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
11.0
31.9
37
40
H40.11
ICD-10 Finland
Low pressure glaucoma
53.3
27.3
32
7
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
4.6
27.2
107
382
CJB10
NOMESCO Finland
Laser discission of secondary cataract
8.5
26.8
38
53
CS1H4
NOMESCO Finland
Retinal nerve fibre layer imaging
28.5
26.7
36
15
S01EE04
ATC
travoprost; ophthalmic
46.5
26.7
32
8
WX140
NOMESCO Finland
Parabulbar anesthesy
9.1
23.6
31
39
CHD50
NOMESCO Finland
Shunt operation on anterior chamber
256.0
23.1
23
*
H26.4
ICD-10 Finland
After-cataract
6.8
22.4
39
68
S01ED02
ATC
betaxolol; ophthalmic
56.2
21.6
25
5
CHD99
NOMESCO Finland
Other filtering operation
+∞
21.2
20
*
CHD00
NOMESCO Finland
Laser trabeculoplasty
85.5
21.1
23
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
3.7
20.0
120
548
H40.19
ICD-10 Finland
Other primary glaucoma with open ventricular angle
115.7
19.9
21
*
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
6.5
19.2
34
60
Z3229
NOMESCO Finland
Other healthcare associate professional
5.7
19.1
40
83
CHD15
NOMESCO Finland
Trabeculectomy and iridectomy
77.0
19.1
21
*
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
3.9
18.7
72
243
H20.1
ICD-10 Finland
Chronic iridocyclitis
36.5
18.4
23
7
S01EA02
ATC
dipivefrine; ophthalmic
73.0
18.0
20
*
H04AA01
ATC
glucagon; nasal, parenteral
8.6
17.8
24
31
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
25.5
16.8
23
10
CHF05
NOMESCO Finland
Transscleral laser coagulation of ciliary body
183.6
16.7
17
*
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
7.0
16.7
27
43
S01EA03
ATC
apraclonidine; ophthalmic
33.0
16.4
21
7
H40.10
ICD-10 Finland
Capsular glaucoma with pseudoexfoliation on the anterior lens capsule
27.0
16.4
22
9
S01EB01
ATC
pilocarpine; ophthalmic
91.9
15.8
17
*
H3603, E103,
ICD-10 Finland
31.3
15.5
20
7
XCH05
NOMESCO Finland
Eye pressure longterm registration
48.8
15.3
18
*
3708
FHL
Trabeculectomy or equivalent
+∞
14.7
14
*
WX100
NOMESCO Finland
Conjunctival surface anesthesia
4.8
14.6
37
90
A10AB05
ATC
insulin aspart; parenteral
4.5
14.4
39
100
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
7.3
14.3
22
33
CS434
NOMESCO Finland
Visual field testing with Humphrey automated perimetry
17.3
14.3
22
14
A10AA02, ,
ATC
6.2
14.2
26
47
S01EC54
ATC
brinzolamide, combinations; ophthalmic
32.5
14.1
18
6
A10AB01
ATC
insulin (human); parenteral
5.7
14.1
28
55
ZXA10
NOMESCO Finland
Bilateral
3.5
13.9
59
209
CHD65
NOMESCO Finland
Nonpenetrating glaucoma surgery
80.4
13.8
15
*
A10AA01, ,
ATC
6.2
13.7
25
45
CS3P4
NOMESCO Finland
Optic nerve head stereophotography
19.9
13.7
20
11
S01BA04
ATC
prednisolone; ophthalmic
19.9
13.7
20
11
H40.4
ICD-10 Finland
Glaucoma secondary to eye inflammation
149.0
13.6
14
*
S01BC03
ATC
diclofenac; ophthalmic
16.5
13.4
21
14
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
6.5
12.9
22
37
3651E
ICD-9 Finland
Glaucoma, Open-angle glaucoma[GLAUCOMA INFANTILE SEU JUVENILE]
+∞
12.6
12
*
H16.0
ICD-10 Finland
Corneal ulcer
5.0
12.6
29
65
S01BA07
ATC
fluorometholone; ophthalmic
15.6
12.5
20
14
S01BA01
ATC
dexamethasone; ophthalmic
6.3
12.5
22
38
A10AC01
ATC
insulin (human); parenteral
4.1
12.2
38
108
CS494
NOMESCO Finland
Other visual field testing
12.8
12.1
21
18
A10AE05
ATC
insulin detemir; parenteral
5.2
11.5
25
53
H40.12
ICD-10 Finland
Pigmentary glaucoma
45.8
11.0
13
*
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
22.9
10.8
15
7
37597
ICD-8 Finland
Glaucoma, Suspicio glaucomatis
115.4
10.5
11
*
Q15.0
ICD-10 Finland
Congenital glaucoma
+∞
10.5
10
*
S01CA02
ATC
prednisolone and antiinfectives; ophthalmic
20.0
10.4
15
8
H40
ICD-10 Finland
Glaucoma
24.8
10.4
14
6
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
21.3
9.9
14
7
CHC05
NOMESCO Finland
Iridotomy
27.5
9.9
13
5
H40.22
ICD-10 Finland
Chronic glaucoma with closed ventricular angle
57.7
9.7
11
*
CHD35
NOMESCO Finland
Laser goniopuncture
57.7
9.7
11
*
XCW10
NOMESCO Finland
Assessment of vision
18.6
9.5
14
8
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
13.2
9.5
16
13
S01FA01
ATC
atropine; ophthalmic
31.6
9.5
12
*
CK2P4
NOMESCO Finland
Optic nerve head light layer imaging (OCT)
+∞
9.4
9
*
103
Kela drug reimbursment
Diabetes, insulin-treated
2.6
9.2
66
308
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
8.0
9.2
20
27
A10AE04
ATC
insulin glargine; parenteral
3.4
9.1
36
120
A10AB04
ATC
insulin lispro; parenteral
4.8
9.1
21
47
215
Kela drug reimbursment
Diabetes, non-insulin-treated
2.6
9.0
64
297
Z94.7
ICD-10 Finland
Corneal transplant status
52.2
8.7
10
*
H54.4
ICD-10 Finland
Blindness, monocular
52.2
8.7
10
*
H40.8
ICD-10 Finland
Other glaucoma
21.1
8.6
12
6
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
15.3
8.3
13
9
ZXA05
NOMESCO Finland
Left side
2.6
8.2
58
267
CKC15
NOMESCO Finland
Panretinal photocoagulation
18.0
8.2
12
7
CFW99
NOMESCO Finland
Other operation on conjunctiva
34.8
8.1
10
*
T89
ICPC
Diabetes insulin dependent
3.9
8.1
25
70
H26.2
ICD-10 Finland
Complicated cataract
10.0
7.9
15
16
H43.1
ICD-10 Finland
Vitreous haemorrhage
10.6
7.7
14
14
H04.10
ICD-10 Finland
Dry eye syndrome
2.9
7.5
38
146
H3600, E103,
ICD-10 Finland
12.6
7.2
12
10
H25.1
ICD-10 Finland
Senile nuclear cataract
2.7
7.1
44
188
WX002
NOMESCO Finland
Sedation and analgesia
2.6
7.1
48
215
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
3.8
6.9
22
63
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
17.4
6.8
10
6
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
17.4
6.8
10
6
H27.0
ICD-10 Finland
Aphakia
41.4
6.8
8
*
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
41.4
6.8
8
*
TCG40
NOMESCO Finland
Measurement of higher-grade errors of refraction
41.4
6.8
8
*
H40.1
ICD-10 Finland
Primary open-angle glaucoma
41.4
6.8
8
*
C10AA05
ATC
atorvastatin; oral
2.2
6.7
83
482
CKD40
NOMESCO Finland
Endophotocoagulation of retina
12.8
6.7
11
9
A10AD01
ATC
insulin (human); parenteral
7.2
6.6
15
22
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.8
6.6
37
150
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
7.8
6.5
14
19
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
3.1
6.5
28
98
CJ2M4
NOMESCO Finland
Scans and measurement printouts for intraocular lens power calculation
71.9
6.5
7
*
WX142
NOMESCO Finland
Sub-tenon anesthesy
71.9
6.5
7
*
E10.1
ICD-10 Finland
Type 1 diabetes mellitus, With ketoacidosis
9.7
6.4
12
13
CG2T4
NOMESCO Finland
Topography assessment of cornea
18.7
6.3
9
5
S01EE51
ATC
latanoprost and netarsudil; ophthalmic
18.7
6.3
9
5
3711
FHL
Cyclodiateria or cryocoagulation
+∞
6.3
6
*
TCA20
NOMESCO Finland
Peribulbar therapeutic injection into orbit
+∞
6.3
6
*
37520
ICD-8 Finland
Glaucoma, Secondary
+∞
6.3
6
*
H18.2
ICD-10 Finland
Other corneal oedema
+∞
6.3
6
*
L04AX01
ATC
azathioprine; systemic
4.4
6.2
16
39

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
93
523
2.37
8.56
6.1
3.6
66.89
62.59
mg/l
0.05
64
345
94
535
2.34
8.37
7.1
4.1
12.29
10.29
mg/mmol
0.12
67
349
98
593
2.19
7.30
5.7
3.4
7.79
8.50
mmol/l
0.56
87
518
53
269
2.29
5.89
5.0
2.2
2.11
2.35
g/l
2.51
48
245
45
214
2.39
5.80
2.6
1.7
—
—
—
0
0
43
214
2.26
4.96
1.7
1.5
—
—
—
0
0
104
727
1.83
4.54
10.2
7.3
1.22
1.21
mmol/l
0.35
99
683
132
994
1.84
4.51
5.7
3.6
0.00
0.00
estimate
-0.00
34
216
131
987
1.83
4.43
5.7
3.5
0.00
0.00
estimate
-0.00
36
211
133
1008
1.83
4.40
5.8
3.6
0.09
0.00
estimate
0.49
33
202
24
96
2.69
4.39
4.6
9.1
23.09
24.92
mmol/l
1.31
24
96
84
559
1.82
4.24
6.1
3.0
106.46
143.54
e6/l
0.10
69
421
80
530
1.81
4.07
2.0
2.1
124.48
183.79
u/l
1.14
75
508
7
7
10.28
4.04
2.6
1.9
—
—
—
0
0
70
448
1.83
3.97
5.8
4.6
—
—
—
0
0
111
821
1.72
3.78
15.4
8.1
1.21
1.21
mmol/l
0.33
98
724
75
500
1.77
3.67
8.2
4.0
7.39
7.40
ph
1.36
58
359
92
650
1.72
3.67
6.5
3.6
22.35
85.60
e6/l
0.75
70
445
7
9
7.99
3.58
65.6
32.6
8.81
6.38
ug/l
—
7
9
109
811
1.69
3.57
4.3
3.1
5.99
6.20
ph
1.39
65
485
11
26
4.40
3.56
1.2
1.4
—
—
—
0
0
71
470
1.76
3.54
5.8
2.7
0.14
0.28
e6/l
1.11
54
340
8
13
6.34
3.53
2.3
5.5
2216.00
961.92
mg
—
8
13
78
533
1.73
3.47
5.8
3.8
0.00
0.00
estimate
0.50
34
201
25
115
2.33
3.44
3.1
2.9
68.11
68.03
g/l
0.01
25
108
101
742
1.68
3.43
8.0
10.3
1.14
1.15
inr
0.10
85
624
30
151
2.15
3.35
7.3
3.3
—
—
—
0
0
12
33
3.79
3.35
1.0
1.1
—
—
—
0
0
125
982
1.65
3.19
10.0
6.6
0.58
0.54
e9/l
1.13
109
879
104
781
1.64
3.17
5.4
3.4
0.00
0.00
estimate
-0.00
31
185
125
985
1.64
3.13
9.9
6.6
0.04
0.04
e9/l
0.54
109
879
29
148
2.11
3.13
10.3
3.4
7.35
7.39
ph
1.71
17
95
124
985
1.61
2.93
5.1
6.2
9.28
11.07
umol/l
2.06
119
941
128
1026
1.61
2.90
10.2
6.9
0.20
0.18
e9/l
0.47
112
929
32
176
1.96
2.83
6.8
12.0
7.44
7.42
ph
0.56
15
103
42
255
1.80
2.76
3.9
2.6
3.58
2.70
e6/l
0.16
24
118
58
389
1.67
2.68
5.8
2.6
4.87
4.78
e6/l
0.02
53
349
25
128
2.08
2.68
3.9
2.8
78.00
71.07
e9/l
0.55
20
93
31
172
1.94
2.68
3.2
2.9
1.84
1.74
%
0.25
31
155
10
30
3.44
2.64
5.2
2.5
—
—
—
0
0
125
1010
1.56
2.63
10.0
6.7
1.74
1.84
e9/l
0.73
111
924
8
20
4.11
2.59
1.6
1.3
31.25
33.10
pg
—
8
20
12
44
2.83
2.59
1.5
1.5
209.86
268.51
ug/g
—
7
22
12
44
2.83
2.59
4.1
2.8
7.41
7.42
ph
0.80
12
44
20
95
2.22
2.58
2.1
2.7
—
—
—
0
0
6
11
5.57
2.56
1.0
1.0
1025.83
1275.18
miu/ml
—
6
11
45
289
1.70
2.43
4.0
3.0
410.83
191.76
ng/l
0.24
36
193
9
28
3.31
2.33
4.1
2.2
9.10
9.25
kpa
—
9
28
9
28
3.31
2.33
4.1
2.2
4.87
5.11
kpa
—
9
28
83
625
1.53
2.33
11.0
6.0
—
—
—
0
0
64
456
1.57
2.29
3.6
2.5
—
—
—
0
0
132
1099
1.52
2.29
12.9
10.4
4.26
4.01
e9/l
0.66
112
977
28
159
1.87
2.27
5.5
5.3
0.00
0.26
%
—
10
46
26
144
1.92
2.27
3.3
2.0
5.87
6.12
ph
0.98
15
81
80
601
1.53
2.26
5.2
2.9
0.00
0.01
estimate
0.80
32
177
17
80
2.22
2.25
7.4
2.9
23.71
24.23
mmol/l
0.37
17
80
112
904
1.50
2.24
10.6
6.5
0.76
0.70
%
0.68
104
856
15
67
2.33
2.23
1.5
1.6
0.20
0.22
g/l
0.56
15
67
75
557
1.53
2.23
3.7
2.6
—
0.25
—
0
8
28
160
1.86
2.23
5.2
5.1
0.32
0.71
%
0.79
11
48
112
905
1.49
2.22
10.5
6.6
8.65
8.53
%
0.20
105
869
161
1404
1.58
2.22
10.7
8.1
77.90
77.39
u/l
0.06
155
1336
29
168
1.84
2.21
5.4
5.1
0.64
0.91
%
0.43
11
56
112
907
1.49
2.19
10.4
6.4
2.89
2.82
%
0.11
105
867
7
19
3.77
2.17
1.7
1.3
0.99
0.90
%
—
7
10
10
36
2.86
2.17
5.5
2.4
8.51
8.55
kpa
—
10
36
28
162
1.84
2.15
5.4
6.0
0.00
0.05
%
—
9
43
24
134
1.89
2.05
12.8
9.9
—
—
—
0
0
104
846
1.44
1.90
17.5
11.0
0.00
0.00
e9/l
0.51
86
701
112
928
1.43
1.83
10.6
6.5
27.31
28.39
%
0.45
106
900
7
24
2.98
1.73
1.4
1.2
—
—
—
0
0
13
62
2.17
1.69
7.5
2.7
1.67
1.39
mg/l
0.58
13
57
5
14
3.63
1.62
1.2
1.1
—
—
—
0
0
58
437
1.45
1.55
2.0
1.7
0.72
0.94
mg/l
0.61
48
340
97
801
1.38
1.54
2.2
1.9
1.34
1.38
mmol/l
0.17
80
689
66
510
1.42
1.54
1.3
1.3
1.92
1.43
u/ml
0.15
22
158
10
46
2.23
1.42
2.3
1.3
135.80
147.74
au/ml
—
5
10
18
293
0.58
1.41
1.5
1.4
—
—
—
0
0
9
41
2.25
1.38
3.2
16.4
1.05
1.12
mmol/l
—
9
36
61
474
1.40
1.37
1.7
1.6
21.79
20.79
nmol/l
0.18
53
409
6
24
2.54
1.31
3.2
2.2
—
—
—
0
0
14
78
1.85
1.24
5.6
2.7
0.64
0.63
%
0.08
14
78
14
78
1.85
1.24
1.0
1.2
—
—
—
0
0
10
49
2.09
1.24
2.8
1.3
—
—
—
0
0
12
64
1.93
1.20
3.5
1.7
—
—
—
0
0
14
79
1.83
1.20
6.5
2.7
1.18
1.46
%
0.43
14
79
176
1636
1.41
1.15
25.9
16.7
13.69
13.40
%
1.97
176
1623
63
506
1.35
1.14
6.5
5.0
—
—
—
0
0
68
553
1.34
1.14
3.1
3.2
—
—
—
0
0
31
220
1.48
1.13
1.4
1.2
—
—
—
0
0
7
31
2.30
1.11
6.4
3.2
4.45
4.66
e9/l
—
7
31
11
59
1.91
1.09
2.1
1.2
—
—
—
0
0
80
671
1.31
1.07
3.5
3.3
48.45
28.20
ng/l
0.53
54
407
54
429
1.34
1.05
5.2
3.5
1.02
1.02
kg/l
0.68
36
288
11
60
1.88
1.05
1.0
1.3
—
—
—
0
0
75
628
1.30
1.01
2.3
2.3
—
—
—
0
0
11
61
1.85
1.00
5.0
8.7
—
—
—
0
0
5
23
2.20
0.98
1.4
1.5
—
—
—
0
0
11
62
1.82
0.96
8.0
12.5
0.65
0.82
%
0.76
11
56
33
247
1.40
0.92
1.5
1.6
1428.70
1219.27
nmol/l
0.57
27
189
15
95
1.62
0.90
1.7
2.0
5.20
5.37
iu/ml
—
5
27
6
29
2.10
0.90
1.2
1.2
—
—
—
0
0
18
121
1.53
0.86
2.1
2.6
160.93
3065.58
u/l
—
9
52
6
31
1.96
0.85
9.7
3.1
8.75
8.89
pmol/l
—
6
31
31
234
1.38
0.83
1.8
2.5
8.54
5.78
umol/l
0.28
23
206
8
46
1.77
0.83
1.3
1.2
—
—
—
0
0
34
261
1.36
0.83
3.8
2.3
—
—
—
0
0
30
226
1.38
0.82
8.5
8.2
102.67
104.17
mmol/l
0.92
30
226
54
446
1.28
0.80
2.7
2.1
3.14
2.87
mg/l
0.39
54
393
19
132
1.48
0.79
1.6
1.4
—
—
—
0
0
182
1730
1.33
0.78
5.7
5.2
1.84
1.78
mu/l
0.34
173
1621
0
27
0.00
0.78
0.0
3.6
—
42.57
—
0
27
0
27
0.00
0.78
0.0
1.3
—
0.16
—
0
20
12
75
1.64
0.76
1.5
1.3
—
—
—
0
0
22
159
1.43
0.76
4.2
2.2
0.00
0.07
estimate
—
6
41
12
76
1.61
0.73
4.1
3.4
—
—
—
0
0
16
109
1.51
0.73
6.8
11.7
1.23
1.54
%
0.71
16
109
11
68
1.65
0.73
1.2
1.4
—
—
—
0
0
5
25
2.02
0.73
1.0
1.8
—
—
—
0
0
7
42
1.69
0.69
7.9
2.8
61.57
58.80
%
—
7
42
5
91
0.54
0.68
1.2
1.6
—
—
—
0
0
5
28
1.80
0.66
8.6
2.1
10.60
10.46
mmol/l
—
5
28
11
71
1.58
0.63
7.5
11.5
1.49
1.50
%
0.01
11
65
83
738
1.20
0.62
2.0
2.0
89.13
96.10
pmol/l
0.87
47
393
153
1439
1.22
0.62
4.6
4.4
14.50
14.58
pmol/l
0.14
142
1340
5
30
1.68
0.62
12.4
5.3
288.00
340.12
umol/l
—
5
25
5
30
1.68
0.62
1.8
1.3
—
—
—
0
0
183
1755
1.28
0.61
9.8
5.6
43.14
38.49
mmol/mol
4.96
176
1677
0
21
0.00
0.60
0.0
2.0
—
—
—
0
0
5
88
0.56
0.57
1.2
1.5
—
—
—
0
0
185
1784
1.26
0.53
5.3
4.4
6.52
5.84
mmol/l
3.48
174
1675
20
257
0.76
0.53
1.4
1.8
—
—
—
0
0
17
127
1.37
0.51
1.3
1.2
—
—
—
0
0
28
342
0.79
0.51
1.8
2.0
—
—
—
0
0
7
47
1.51
0.48
1.1
1.6
—
—
—
0
0
54
473
1.19
0.47
3.7
2.6
351.41
337.60
umol/l
0.44
46
427
36
303
1.23
0.47
1.6
1.4
502.86
483.58
titre
—
7
67
20
157
1.30
0.45
9.0
4.5
7.35
7.30
ph
0.15
15
119
17
131
1.32
0.43
1.0
1.1
—
—
—
0
0
6
94
0.63
0.43
1.5
1.1
—
0.65
—
0
11
8
56
1.44
0.43
1.1
1.3
—
—
—
0
0
14
105
1.36
0.42
7.2
12.0
0.82
0.63
%
0.89
14
105
0
15
0.00
0.41
0.0
3.6
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
20
243
0.80
0.36
1.6
1.5
—
—
—
0
0
59
535
1.14
0.34
8.8
6.2
—
—
—
0
0
45
400
1.16
0.34
1.4
1.3
24.57
27.81
iu/ml
—
7
114
7
97
0.71
0.31
1.4
1.1
1.56
1.53
g/l
—
7
97
7
100
0.69
0.31
1.4
1.1
0.85
0.89
g/l
—
7
100
7
55
1.28
0.30
5.1
2.5
—
—
—
0
0
52
571
0.88
0.30
2.1
2.1
—
—
—
0
0
192
1880
1.19
0.30
22.6
13.9
22.04
22.42
mg/l
0.06
170
1527
12
94
1.29
0.28
4.5
9.3
—
—
—
0
0
14
113
1.26
0.27
1.1
1.1
—
—
—
0
0
5
71
0.70
0.26
1.2
1.1
—
—
—
0
0
14
114
1.24
0.26
1.1
1.1
—
—
—
0
0
78
735
1.10
0.23
2.4
1.9
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.9
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
8.0
—
10.20
—
0
10
0
10
0.00
0.21
0.0
2.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
0.00
—
0
10
0
10
0.00
0.21
0.0
4.0
—
39.50
—
0
10
11
134
0.81
0.21
3.9
1.9
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
328.00
—
0
7
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
6
76
0.78
0.16
2.2
2.2
—
—
—
0
0
7
88
0.79
0.15
7.3
2.9
—
—
—
0
0
21
189
1.12
0.14
1.3
1.2
—
—
—
0
0
21
232
0.89
0.14
1.3
1.3
—
—
—
0
0
34
365
0.92
0.13
3.1
2.8
0.59
0.80
ug/l
1.50
19
189
11
94
1.18
0.13
1.4
1.8
—
—
—
0
0
12
137
0.87
0.12
3.9
1.6
—
—
—
0
0
39
367
1.08
0.12
1.3
1.3
1.48
6.04
u/ml
2.01
17
150
26
241
1.09
0.11
1.2
1.2
—
—
—
0
0
45
473
0.94
0.11
1.9
1.8
—
—
—
0
0
12
135
0.88
0.10
3.9
1.9
—
—
—
0
0
5
46
1.09
0.09
4.0
4.6
3.80
3.87
mmol/l
—
5
46
12
133
0.90
0.08
3.8
1.9
—
—
—
0
0
15
137
1.10
0.07
1.8
1.7
1.40
1.59
g/l
0.22
15
128
8
75
1.07
0.07
1.5
1.2
—
99.09
—
0
11
14
153
0.91
0.07
1.9
4.7
2.04
34.72
ug/l
—
8
127
8
92
0.86
0.07
6.4
2.6
22.25
40.08
u/ml
—
8
87
57
587
0.96
0.06
4.3
4.4
1.55
2.04
ug/l
0.64
51
529
60
616
0.96
0.06
1.7
1.6
—
—
—
0
0
90
917
0.97
0.06
2.8
2.8
—
—
estimate
—
0
0
190
1887
1.06
0.05
5.9
4.6
1.42
1.44
mmol/l
0.20
176
1784
22
208
1.06
0.05
1.6
1.5
—
—
—
0
0
13
122
1.07
0.02
1.2
1.2
—
—
—
0
0
34
333
1.02
0.01
2.1
1.6
—
—
—
0
0
89
897
0.99
0.01
3.1
2.9
—
—
—
0
0
11
104
1.06
0.01
3.8
1.9
—
—
—
0
0
190
1894
1.03
0.00
6.0
4.7
4.65
4.70
mmol/l
0.26
177
1797
145
1456
0.99
0.00
4.0
3.3
50.39
46.00
u/l
0.34
137
1396
11
114
0.96
0.00
2.4
1.5
0.13
0.30
mg/l
—
6
44
12
124
0.97
0.00
3.8
1.9
—
—
—
0
0
197
1974
0.98
0.00
18.7
12.4
—
—
—
0
0
22
216
1.02
0.00
1.3
1.9
3.77
3.51
mmol/l
0.41
12
158
12
123
0.97
0.00
1.7
1.7
—
—
—
0
0
32
317
1.01
0.00
1.4
1.6
—
—
—
0
0
181
1805
1.02
0.00
5.0
3.9
1.33
1.28
mmol/l
0.32
168
1696
47
465
1.01
0.00
1.6
1.4
3.07
2.42
g/l
0.75
34
310
191
1912
0.99
0.00
6.7
5.1
2.79
2.81
mmol/l
0.07
179
1815
5
53
0.94
0.00
1.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
95.96
—
0
8
5
53
0.94
0.00
1.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
0.38
—
0
5
0
7
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.0
—
—
—
0
0
5
55
0.91
-0.00
1.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.3
—
18.33
—
0
6
0
5
0.00
-0.00
0.0
3.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
1.18
—
0
5
0
7
0.00
-0.00
0.0
1.4
—
59.00
—
0
7
5
54
0.92
-0.00
1.6
2.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
57.02
—
0
6
0
9
0.00
-0.00
0.0
2.1
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint H7_GLAUCOMA_JOAG and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have H7_GLAUCOMA_JOAG.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: H7_GLAUCOMA_JOAG – Juvenile Open Angle Glaucoma

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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