Other degenerative disorders of eyelid and periocular area

H7_EYELIDDEGEN

eyelid disease: A disease involving the eyelid.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H02.7 Hospital discharge: ICD-9 — 3745 Cause of death: ICD-10 — H02.7 Cause of death: ICD-9 — 3745 2 out of 7 registries used, show all original rules.	120
4. Check minimum number of events None	120
5. Include endpoints None	120
6. Filter based on genotype QC (FinnGen only)	109

Control definitions (FinnGen only)

Control exclude: H7_LIDLACRIMALORBIT

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: H02
Name in latin: Aliae morbositates degenerativae palpebrarum et areae periocularis

NAME	H7_EYELIDDEGEN
CONTROL_EXCLUDE	H7_LIDLACRIMALORBIT
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H027
HD_ICD_9	3745
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H027
COD_ICD_9	3745
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Other degenerative disorders of eyelid and periocular area based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	546	357	187
Only index persons	490	322	168
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	57.83	56.55	60.40
Only index persons	57.18	55.57	60.24

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	109	63	46
Unadjusted period prevalence (%)	0.02	0.02	0.02
Median age at first event (years)	59.98	56.40	64.88

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
112: Matched controls
1120

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

H02.7

ICD-10 Finland

Other degenerative disorders of eyelid and periocular area

+∞

118.9

H02.3

ICD-10 Finland

Blepharochalasis

126.7

49.0

CBJ50

NOMESCO Finland

Operation for ptosis of eyebrow

351.5

28.1

CBB21

NOMESCO Finland

Correction of lax skin and resection of herniated fat in upper eyelid

+∞

22.7

3745A

ICD-9 Finland

Other disorders of eyelids, Degenerative disorders of eyelid and periocular area

+∞

21.5

QAJ10

NOMESCO Finland

Browlift

+∞

19.3

WX704

NOMESCO Finland

Intubation

9.4

19.1

CBB11

NOMESCO Finland

Resection of lax skin in upper eyelid

+∞

18.2

H02.5

ICD-10 Finland

Other disorders affecting eyelid function

+∞

14.9

WX725

NOMESCO Finland

Noninvasive ventilation

13.2

14.7

CBB10

NOMESCO Finland

Excision of redundant skin of eyelid

+∞

13.8

WX700

NOMESCO Finland

Respiratory and circulatory monitoring

5.1

13.8

103

H02.4

ICD-10 Finland

Ptosis of eyelid

158.4

13.8

TPH04

NOMESCO Finland

Cathetrisation of vein

4.4

13.0

163

WX720

NOMESCO Finland

Own respiration

12.0

11.6

N02AX02

ATC

tramadol; systemic, rectal

3.6

10.2

334

3201

FHL

Removal of a small eyelid tumor in the operating room

97.1

8.5

WX702

NOMESCO Finland

Supraglottic ventilation device

8.0

8.2

Z01.8

ICD-10 Finland

Other specified special examinations

3.3

8.0

160

M51.3

ICD-10 Finland

Other specified intervertebral disc degeneration

4.8

7.6

CBB20

NOMESCO Finland

Correction of lax skin of eyelid and resection of herniated fat

+∞

6.3

WX400

NOMESCO Finland

Inhalation anesthesy

9.4

6.2

G55.2*M47.9

ICD-10 Finland

Nerve root and plexus compressions in spondylosis

13.6

6.2

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3019150) Specific gravity of Urine by Refractometry

247

2.75

6.26

5.6

3.9

1.02

kg/l

0.28

158

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

406

2.10

3.64

2.2

2.0

1.26

1.38

mmol/l

0.92

335

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

197

2.22

3.54

5.3

3.3

67.04

354.84

ng/l

1.11

151

(3031040) Bacteria [#/volume] in Urine by Automated count

660

2.31

3.47

6.0

4.5

—

267.46

—

(3019060) Gas panel - Arterial blood

2.71

2.94

4.4

3.7

—

(3026008) Bacteria identified in Urine by Culture

295

1.95

2.88

3.5

3.4

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

107

956

3.67

2.86

19.0

16.0

22.38

23.87

mg/l

0.20

788

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

442

1.83

2.54

2.2

2.0

88.43

96.80

pmol/l

0.88

229

(3021589) Normoblasts [#/volume] in Blood

466

0.51

2.50

8.0

12.0

0.00

0.01

e9/l

0.55

381

(3032080) INR in Blood by Coagulation assay

500

1.78

2.28

21.3

11.6

1.25

1.24

inr

0.04

402

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

3.04

2.27

1.8

2.4

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

3.17

2.20

1.8

2.3

—

(3042936) Bacteria identified in Isolate by Culture

151

1.94

2.11

1.7

1.9

—

(3012516) Albumin [Mass/volume] in Urine

334

1.70

1.96

3.7

3.2

93.99

62.98

mg/l

0.32

220

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

2.09

1.93

1.6

1.5

—

(3018418) pH of Serum or Plasma

339

1.67

1.83

5.5

4.2

7.40

0.17

243

(3019977) pH of Arterial blood

130

1.86

1.69

4.8

7.1

7.40

7.41

0.31

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

2.92

1.68

3.1

2.1

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

468

1.61

1.67

3.4

2.6

—

estimate

—

(3021960) Folate [Moles/volume] in Serum or Plasma

302

1.63

1.62

1.7

21.67

20.93

nmol/l

0.12

246

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

542

1.59

1.56

8.2

6.6

1.21

mmol/l

0.04

459

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

2.34

1.51

2.4

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

2.49

1.49

1.0

1.2

—

(3030981) Hyaline casts [#/volume] in Urine by Automated count

1.93

1.46

2.6

2.5

1.57

0.21

e6/l

0.49

(3020682) Albumin/Creatinine [Ratio] in Urine

346

1.56

1.45

4.1

3.8

21.99

10.20

mg/mmol

0.59

219

(3035350) Ketones [Presence] in Urine by Test strip

559

1.55

1.43

4.9

4.0

0.00

estimate

—

118

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

2.30

1.41

2.3

3.1

—

(3009261) Glucose [Presence] in Urine by Test strip

562

1.53

1.37

4.9

4.0

0.00

estimate

—

108

(3020630) Protein [Mass/volume] in Serum or Plasma

1.91

1.35

2.0

2.6

66.48

67.01

g/l

0.18

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

2.19

1.34

1.1

1.0

—

(4024509) Urine culture

2.19

1.32

2.2

1.6

—

(3049717) Cytology report of Urine Cyto stain

2.31

1.27

2.5

2.4

—

(40761511) CBC panel - Blood by Automated count

106

993

2.26

1.26

20.4

13.7

—

(3002256) Pathology report gross observation

130

0.43

1.25

1.0

1.3

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

119

1.72

1.21

1.9

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.88

1.16

1.4

2.2

—

(40760888) Immunoglobulin light chains.free panel - Serum

2.57

1.16

1.0

4.5

—

(3021601) Nitrite [Presence] in Urine by Test strip

556

1.46

1.12

5.0

3.9

0.00

estimate

—

118

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

261

1.50

1.11

5.7

4.4

21.25

22.20

0.16

129

(3013650) Neutrophils [#/volume] in Blood by Automated count

577

1.45

1.10

7.1

10.1

4.02

4.12

e9/l

0.14

501

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

420

1.44

1.10

4.9

3.9

0.00

estimate

—

100

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

183

1.55

1.06

1.5

1.3

1.60

10.72

u/ml

—

(3022145) Colonoscopy Study observation

119

0.48

1.01

1.2

1.4

—

(1761482) Bacteria [#/volume] in Urine by Culture

0.00

0.99

0.0

5.3

—

(46236952) Glomerular filtration rate [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)/1.73 sq M

1.72

0.96

3.2

2.8

53.00

64.93

ml/min/173m2

—

(3015736) pH of Urine

441

1.38

0.90

5.1

3.6

6.52

6.22

1.02

243

(40758558) Short blood count panel - Blood

309

1.40

0.88

4.6

6.7

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

209

1.45

0.87

1.5

1.3

81.09

38.61

iu/ml

0.25

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

247

1.41

0.83

1.8

1.6

0.66

1.61

mg/l

2.37

196

(36660697) Celiac disease serology panel - Serum

1.70

0.82

1.2

1.3

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

100

0.48

0.82

1.2

2.2

333.40

371.23

nmol/l

—

(40768793) Breast Pathology biopsy report

0.00

0.80

0.0

1.3

—

(40764999) Glomerular filtration rate [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)/1.73 sq M

943

0.69

0.79

14.9

15.9

75.89

79.08

ml/min/173m2

0.75

869

(3048929) Epstein Barr virus Ab [Presence] in Serum

2.23

0.77

1.0

1.2

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.66

0.74

1.4

1.3

—

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

1.60

0.72

4.8

2.6

3.30

5.86

ug/l

1.40

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

1.96

0.71

2.0

1.2

—

(3008898) HLA-B27 [Presence]

1.71

0.70

1.0

1.1

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

129

1.47

0.69

2.1

1.7

—

(40761535) Cells panel - Urine sediment

1.56

0.67

6.7

4.0

—

(3018095) Leukocytes [#/volume] in Urine

399

1.31

0.66

4.3

4.1

13.36

50.87

e6/l

1.58

280

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

131

1.45

0.64

1.3

1.5

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.61

0.62

1.8

1.7

—

(3003694) ABO and Rh group [Type] in Blood

281

0.73

0.61

1.2

1.4

—

(3000494) Fungus identified in Specimen by Culture

115

1.46

0.60

1.2

1.5

—

(40765161) Human bocavirus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.60

0.0

1.7

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

403

1.29

0.60

6.4

4.1

27.58

33.26

ng/l

0.28

299

(1761868) Lipid panel - Serum or Plasma

385

0.76

0.59

2.4

3.4

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

170

1.37

0.57

2.0

1.9

—

(3001604) Monocytes [#/volume] in Blood

504

1.27

0.56

5.5

6.0

0.55

0.58

e9/l

0.40

430

(40768804) Tissue Pathology biopsy report

392

0.78

0.55

2.0

2.1

—

(3006315) Basophils [#/volume] in Blood

506

1.26

0.54

5.5

6.0

0.04

e9/l

0.18

430

(3001334) Neutrophil cytoplasmic Ab [Units/volume] in Serum

1.57

0.54

1.2

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

568

1.25

0.51

3.3

2.8

—

(3033658) Prothrombin time (PT) actual/Normal

252

0.75

0.51

3.7

4.1

90.85

0.00

245

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

165

1.34

0.49

1.9

1.4

—

(3037522) Nuclear Ab [Titer] in Serum

147

1.35

0.49

1.6

1.4

112.00

451.11

titre

—

(3013115) Eosinophils [#/volume] in Blood

521

1.23

0.48

5.6

6.3

0.20

0.19

e9/l

0.27

450

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

238

0.76

0.46

2.8

2.3

—

(3019198) Lymphocytes [#/volume] in Blood

514

1.22

0.44

5.5

6.0

2.01

1.91

e9/l

0.29

450

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.42

0.44

1.9

1.7

—

(3020891) Body temperature

1.46

0.44

3.9

36.82

36.98

°c

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

1.54

0.42

1.0

1.2

0.95

0.90

g/l

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

0.41

0.0

1.1

—

(40768795) Lymph node Pathology biopsy report

0.00

0.41

0.0

1.1

—

(3007853) Bacteria identified in Skin by Aerobe culture

124

1.34

0.41

2.3

1.6

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

678

1.22

0.41

3.0

3.1

41.49

51.24

u/l

0.82

635

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.5

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.41

0.0

1.5

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

0.00

0.39

0.0

2.5

—

32.32

—

(3000012) Reticulocyte production index

0.00

0.39

0.0

2.6

—

1.00

—

(40760892) CBC W Ordered Manual Differential panel - Blood

220

1.24

0.36

4.2

6.1

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

119

1.30

0.34

19.8

7.8

—

(36304419) Bacteria [Presence] in Urine

291

1.19

0.31

3.6

3.0

—

estimate

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

188

1.21

0.28

3.9

3.1

1.18

1.11

e6/l

0.05

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.27

0.26

1.6

1.4

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.28

0.26

2.0

1.7

—

(3014007) Fractional oxyhemoglobin in Arterial blood

1.22

0.25

4.6

9.6

93.97

94.72

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

1.33

0.23

1.6

1.2

—

(3030467) Casts [#/volume] in Urine by Automated count

312

0.86

0.23

4.0

3.2

0.07

0.44

e6/l

2.50

229

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

231

1.16

0.22

1.3

0.44

1.67

u/ml

—

(3000991) Gas panel - Venous blood

102

0.77

0.22

11.1

8.0

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

104

0.75

0.22

10.1

3.7

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.21

0.0

3.6

—

1.09

—

(3016881) Enterovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.0

—

(3046294) Neutrophil cytoplasmic Ab.classic [Titer] in Serum

0.00

0.21

0.0

1.0

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.4

—

(3025023) Rhinovirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.0

—

(3016018) Differential panel - Cerebral spinal fluid

0.00

0.21

0.0

1.0

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.21

0.0

3.4

—

(21494815) CD4 cells/Lymphocytes in Specimen

0.00

0.21

0.0

2.0

—

33.49

—

(40768441) Liver Pathology biopsy report

0.00

0.21

0.0

1.0

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.21

0.0

1.6

—

(40768806) Pleura Pathology biopsy report

0.00

0.21

0.0

2.6

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.21

0.0

3.0

—

42.27

—

(40759843) Sjogrens syndrome-A extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.5

—

(40759850) Jo-1 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.5

—

(40759836) Histone Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.5

—

(40759844) Sjogrens syndrome-B extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.5

—

(3011648) Oxygen content in Venous blood

0.00

0.21

0.0

1.1

—

9.97

—

(40759849) Smith extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.5

—

(3018333) Ribosomal P Ab [Presence] in Serum

0.00

0.21

0.0

1.4

—

(3004809) Band form neutrophils/Leukocytes in Blood

0.00

0.21

0.0

3.8

—

1.67

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.21

0.0

1.4

—

(3035285) Chloride [Moles/volume] in Venous blood

0.00

0.21

0.0

3.2

—

106.15

—

(3020148) Glutamate decarboxylase 65 Ab [Units/volume] in Serum

0.00

0.21

0.0

1.3

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.0

—

(3023410) Appearance of Cerebral spinal fluid

0.00

0.21

0.0

1.2

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

0.21

0.0

1.0

—

(3041354) Potassium [Moles/volume] in Venous blood

0.00

0.21

0.0

3.2

—

4.03

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.0

—

(3033705) Calcium.ionized [Moles/volume] in Venous blood

0.00

0.21

0.0

3.2

—

1.18

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

2.0

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.24

0.20

1.5

—

(3042596) Human coronavirus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.20

0.0

1.4

—

(3045716) Anion gap in Serum or Plasma by calculation

0.00

0.20

0.0

1.6

—

10.79

—

(40759812) SCL-70 extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.20

0.0

1.4

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

131

0.82

0.18

5.1

1.6

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.15

0.17

2.1

1.5

—

(4010399) Spirometry for bronchospasm with prolonged evaluation after bronchodilator

1.22

0.16

1.9

1.3

—

(42870588) Differential panel, method unspecified - Blood

335

1.11

0.15

5.6

5.2

—

(3017732) Neutrophils [#/volume] in Blood

131

1.17

0.15

2.5

2.8

3.75

6.61

e9/l

0.82

109

(3002582) Erythrocytes [#/volume] in Urine

356

1.10

0.14

4.1

3.3

16.40

45.25

e6/l

1.47

268

(3013512) EKG study

364

0.91

0.14

3.3

3.6

—

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

0.80

0.14

2.3

2.9

992.00

27.78

u/l

—

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

577

1.09

0.12

4.4

6.6

9.03

11.60

umol/l

1.51

545

(3023368) Bacteria identified in Blood by Culture

291

1.09

0.11

4.9

4.3

—

(40768443) Skin Pathology biopsy report

1.14

0.10

1.2

1.3

—

(3045424) Erythrocytes [Presence] in Urine

1.07

0.09

2.0

2.3

—

0.00

estimate

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

1.08

0.08

7.7

2.5

0.59

0.63

—

(3029937) Albumin [Presence] in Urine by Test strip

316

0.93

0.08

7.2

4.1

0.00

estimate

—

108

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.05

0.08

7.7

2.5

0.74

1.23

—

(3019832) Treponema pallidum Ab [Presence] in Serum

0.85

0.08

1.7

1.6

—

(3028026) IgM [Mass/volume] in Serum or Plasma

1.10

0.08

1.6

1.5

0.92

1.36

g/l

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.05

0.07

1.6

1.4

—

(3012544) pH of Venous blood

109

1.11

0.06

7.9

3.3

7.38

—

(3044640) Blood type and Crossmatch panel - Blood

323

0.94

0.05

2.5

2.3

—

(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction

120

0.91

0.05

2.0

4.7

209.45

254.22

u/l

1.98

110

(46235355) HIV 1 and 2 tests - Meaningful Use set

162

1.06

0.02

3.8

1.7

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

166

0.96

0.00

4.0

3.2

1.85

1.99

e6/l

—

(3045414) Leukocytes [Presence] in Urine

1.02

0.00

2.2

—

0.00

estimate

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

113

0.97

0.00

5.1

1.5

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

163

0.98

0.00

6.3

6.7

104.50

104.15

mmol/l

0.19

163

(3007164) IgA [Mass/volume] in Serum or Plasma

213

0.98

0.00

1.5

1.4

1.97

2.84

g/l

1.52

135

(40768797) Stomach Pathology biopsy report

136

1.03

0.00

1.5

1.2

—

(3048689) Calprotectin [Mass/mass] in Stool

115

0.95

0.00

1.4

2.6

39.73

166.73

ug/g

2.12

(21494755) Public health laboratory ask at order entry panel

0.99

0.00

1.3

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.2

—

(3007821) Glucose [Moles/volume] in Serum or Plasma --baseline

0.00

0.0

1.2

—

6.60

—

(40759883) Oligoclonal Bands IgG [Presence] in Cerebral spinal fluid by Isoelectric focusing

0.00

0.0

1.0

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

0.0

1.0

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

0.0

1.2

—

(3045066) Thymidine kinase [Enzymatic activity/volume] in Serum

0.00

0.0

1.7

—

16.63

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

0.0

1.2

—

(21492888) Glucose tolerance 2 hours gestational panel - Serum or Plasma

0.00

0.0

2.3

—

(40771527) Human papilloma virus E6+E7 mRNA [Presence] in Cervix by NAA with probe detection

0.00

0.0

1.7

—

(3014271) Vancomycin [Susceptibility]

0.00

0.0

2.0

—

(3043410) Blood group antigens tested for on Red Blood Cells

0.00

0.0

1.5

—

(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.5

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

0.0

1.5

—

6.73

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.5

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

-0.00

0.0

2.6

—

10.44

—

(42529582) MDA5 Ab [Presence] in Serum by Line blot

0.00

-0.00

0.0

1.0

—

(42529598) SUMO-activating enzyme subunit 1 Ab [Presence] in Serum by Line blot

0.00

-0.00

0.0

1.0

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

-0.00

0.0

1.1

—

(3021197) Magnesium Ionized [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

0.59

—

(3044927) Protein electrophoresis panel - Urine

0.00

-0.00

0.0

1.1

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

-0.00

0.0

2.6

—

4.57

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

-0.00

0.0

1.7

—

(37208534) Antinuclear antibody arbitrary concentration in serum

0.00

-0.00

0.0

1.0

—

(3006442) Creatine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

2.1

—

77.57

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3012565) Volume of 24 hour Urine

0.00

-0.00

0.0

2.6

—

1942.86

—

(3013637) Mi-2 Ab [Presence] in Serum

0.00

-0.00

0.0

1.0

—

(3035320) C reactive protein [Mass/volume] in Body fluid

0.00

-0.00

0.0

2.4

—

30.00

—

(3036432) Mycobacterium tuberculosis genotype [Identifier] in Isolate

0.00

-0.00

0.0

12.6

—

(3000492) Spirometry study

0.92

-0.00

1.2

1.5

—

(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.7

—

(3035999) Lactate [Moles/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.2

—

1.65

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

-0.00

0.0

1.0

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

-0.00

0.0

1.7

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

-0.00

0.0

1.7

—

(3024666) Lithium [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

7.7

—

0.65

—

(3051651) Icteric interference index of Serum or Plasma

0.00

-0.00

0.0

2.0

—

1.00

—

(40765096) Chromosome analysis panel by Banding

0.00

-0.00

0.0

1.1

—

(40764127) Haemophilus influenzae DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.6

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

-0.00

0.0

1.3

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

-0.00

0.0

1.0

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

5.4

—

2300.20

—

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.4

—

49.21

—

(3034274) Bile acid [Moles/volume] in Serum --fasting

0.00

-0.00

0.0

3.0

—

7.99

—

(3016724) Homocysteine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.6

—

13.80

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

0.92

-0.00

1.8

1.2

—

(3025941) Bacteria identified in Stool by Culture

0.90

-0.00

2.2

1.3

—

(3016436) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma

0.00

-0.00

0.0

6.2

—

195.80

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

-0.00

0.0

1.1

—

(3024474) Albumin [Mass/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

253.29

—

(42528593) TIF1-gamma Ab [Presence] in Serum by Line blot

0.00

-0.00

0.0

1.0

—

(3035880) pH of Pleural fluid

0.00

-0.00

0.0

1.9

—

7.28

—

(4146454) Self-monitoring of blood glucose

0.00

-0.00

0.0

3.4

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

0.00

-0.00

0.0

1.5

—

(3017569) Oxygen content in Arterial blood

0.00

-0.00

0.0

1.6

—

16.64

—

(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

2.2

—

363.80

—

(40757349) CD3+CD4+ (T4 helper) cells/CD3+CD8+ (T8 suppressor cells) cells [# Ratio] in Blood

0.00

-0.00

0.0

1.4

—

1.19

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3049506) Microalbumin [Mass/time] in Urine collected for unspecified duration

0.00

-0.00

0.0

2.6

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

-0.00

0.0

1.8

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

0.00

-0.00

0.0

1.2

—

(3035637) Corticotropin [Mass/volume] in Plasma

0.00

-0.00

0.0

1.4

—

58.56

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

-0.00

0.0

1.0

—

(44806420) Estimation of glomerular filtration rate

0.00

-0.00

0.0

2.7

—

(3038026) Centromere Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

(3050129) First trimester maternal screen panel - Serum or Plasma

0.00

-0.00

0.0

1.4

—

Mortality – FinRegistry

↥

Association

Association between endpoint H7_EYELIDDEGEN and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have H7_EYELIDDEGEN.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: H7_EYELIDDEGEN – Other degenerative disorders of eyelid and periocular area

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Other degenerative disorders of eyelid and periocular area

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints