corneal edema: Hazy, swollen cornea.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
329 |
4. Check minimum number of eventsNone |
329 |
5. Include endpointsNone |
329 |
6. Filter based on genotype QC (FinnGen only) |
303 |
Control definitions (FinnGen only)
- Control exclude
- H7_SCLERACORNEA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H18
- Name in latin
- Aliud oedema corneae
Similar endpoints
↥List of similar endpoints to
Other corneal oedema
based on the number of shared cases.
Similar with more cases:
- Other disorders of cornea
- Disorders of sclera, cornea, iris and ciliary body
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2050 | 1197 | 844 |
| Only index persons | 1836 | 1082 | 754 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.03 | 0.02 |
| Only index persons | 0.04 | 0.04 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 73.26 | 75.52 | 70.07 |
| Only index persons | 72.97 | 75.20 | 69.78 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 303 | 173 | 130 |
| Unadjusted period prevalence (%) | 0.06 | 0.06 | 0.06 |
| Median age at first event (years) | 72.50 | 73.04 | 71.77 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 315
- Matched controls
- 3150
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H18.2
ICD-10 Finland
Other corneal oedema
+∞
307.7
307
*
Z96.1
ICD-10 Finland
Presence of intraocular lens
13.0
120.9
205
394
H16.0
ICD-10 Finland
Corneal ulcer
33.8
100.6
67
25
Z94.7
ICD-10 Finland
Corneal transplant status
+∞
70.5
65
*
WX140
NOMESCO Finland
Parabulbar anesthesy
11.2
66.4
80
93
S01EA05
ATC
brimonidine; ophthalmic
17.6
60.2
52
35
S01ED51
ATC
timolol, combinations; ophthalmic
8.0
58.1
96
163
S01ED01
ATC
timolol; ophthalmic
13.7
56.7
57
50
S01EC01
ATC
acetazolamide; systemic
18.1
52.2
44
28
XCW99
NOMESCO Finland
Other investigative procedure of eye
6.5
50.1
105
225
H18.5
ICD-10 Finland
Hereditary corneal dystrophies
+∞
48.2
45
*
H18.1
ICD-10 Finland
Bullous keratopathy
+∞
48.2
45
*
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
5.7
47.8
223
938
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
+∞
44.9
42
*
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
5.7
43.7
236
1089
WX100
NOMESCO Finland
Conjunctival surface anesthesia
5.2
43.3
125
352
CGG31
NOMESCO Finland
Posterior corneal lamellar transplantation
+∞
42.7
40
*
CG2T4
NOMESCO Finland
Topography assessment of cornea
89.1
42.2
46
6
H16.9
ICD-10 Finland
Keratitis, unspecified
439.5
40.0
39
*
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
5.1
39.0
233
1126
CG2X4
NOMESCO Finland
Optical coherence tomography (OCT) of cornea
196.1
34.5
35
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.4
34.4
123
400
XCK10
NOMESCO Finland
Photography of fundus of eye
5.2
33.3
82
198
H25.1
ICD-10 Finland
Senile nuclear cataract
4.1
32.5
198
927
XCK00
NOMESCO Finland
Perimetry
6.0
30.1
60
119
TCG10
NOMESCO Finland
Removal of sutures from cornea
114.2
29.2
31
*
114
Kela drug reimbursment
Glaucoma
4.7
28.8
81
216
H40.10
ICD-10 Finland
Capsular glaucoma with pseudoexfoliation on the anterior lens capsule
8.4
28.2
39
52
S01EC04
ATC
brinzolamide; ophthalmic
6.8
27.7
47
79
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
4.6
27.3
79
215
H20.1
ICD-10 Finland
Chronic iridocyclitis
+∞
26.4
25
*
CHD50
NOMESCO Finland
Shunt operation on anterior chamber
+∞
25.3
24
*
CGG45
NOMESCO Finland
Full thickness transplantation of cornea using homograft
+∞
25.3
24
*
Z3229
NOMESCO Finland
Other healthcare associate professional
4.7
24.0
63
158
CG2S4
NOMESCO Finland
Photography of cornea
70.5
23.2
26
*
H26.4
ICD-10 Finland
After-cataract
3.9
22.7
81
255
H18.6
ICD-10 Finland
Keratoconus
+∞
22.1
21
*
CJB10
NOMESCO Finland
Laser discission of secondary cataract
4.1
21.8
71
209
S01EE05
ATC
tafluprost; ophthalmic
6.0
21.0
40
75
H18.8
ICD-10 Finland
Other specified disorders of cornea
224.2
20.8
21
*
CHB15
NOMESCO Finland
Puncture of anterior chamber of eye with replacement of aqueous
+∞
20.0
19
*
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
5.2
19.6
44
96
S01EA03
ATC
apraclonidine; ophthalmic
21.8
19.4
28
14
S01AD03
ATC
aciclovir; ophthalmic
7.8
19.4
28
39
H57.1
ICD-10 Finland
Ocular pain
7.6
19.0
28
40
WX002
NOMESCO Finland
Sedation and analgesia
3.1
18.9
106
440
S01EE01
ATC
latanoprost; ophthalmic
4.3
18.1
53
143
H18.4
ICD-10 Finland
Corneal degeneration
+∞
17.9
17
*
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
18.3
17.7
27
16
CHB10
NOMESCO Finland
Puncture of anterior chamber of eye with irrigation
30.9
17.7
23
8
XCH00
NOMESCO Finland
Eye pressure measurement
5.0
17.4
40
89
S01EE03
ATC
bimatoprost; ophthalmic
6.9
16.9
27
42
ZXA05
NOMESCO Finland
Left side
2.7
15.9
123
599
TCG00
NOMESCO Finland
Protection of cornea and sclera with soft lens
89.6
15.7
17
*
H40.0
ICD-10 Finland
Glaucoma suspect
3.6
13.9
52
166
H19.1*B00.5
ICD-10 Finland
Herpesviral keratoconjunctivitis
+∞
13.6
13
*
ZXA00
NOMESCO Finland
Right side
2.5
13.5
128
677
CHF05
NOMESCO Finland
Transscleral laser coagulation of ciliary body
29.8
13.1
17
6
WX142
NOMESCO Finland
Sub-tenon anesthesy
25.6
12.6
17
7
S01EC03
ATC
dorzolamide; ophthalmic
15.2
12.4
20
14
WX006
NOMESCO Finland
Intravenous sedation or analgesia without general anesthesia
3.8
12.4
41
120
H04.10
ICD-10 Finland
Dry eye syndrome
3.1
12.2
56
203
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
3.9
12.1
38
107
S01EE04
ATC
travoprost; ophthalmic
9.5
12.0
24
27
H26.2
ICD-10 Finland
Complicated cataract
17.3
11.8
18
11
CHD99
NOMESCO Finland
Other filtering operation
24.0
11.7
16
7
H16.2
ICD-10 Finland
Keratoconjunctivitis
+∞
11.5
11
*
CJF30
NOMESCO Finland
Reduction of dislocation of artificial lens
124.4
11.5
12
*
S01EX03, ,
ATC
9.5
11.5
23
26
H26.02
ICD-10 Finland
Presenil cataract
5.8
11.3
21
38
S01EC54
ATC
brinzolamide, combinations; ophthalmic
14.6
11.1
18
13
H35.36
ICD-10 Finland
Macular cyst
29.2
10.8
14
5
S01BC03
ATC
diclofenac; ophthalmic
10.6
10.7
20
20
CGG35
NOMESCO Finland
Transplantation of endothelium of cornea
+∞
10.5
10
*
S01EB01
ATC
pilocarpine; ophthalmic
19.6
10.4
15
8
ZXA10
NOMESCO Finland
Bilateral
2.4
10.2
91
459
T85.2
ICD-10 Finland
Mechanical complication of intraocular lens
41.5
10.0
12
*
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
3.6
9.9
34
102
Z3231
NOMESCO Finland
Registered nurse
2.2
9.8
111
618
S01BA04
ATC
prednisolone; ophthalmic
8.3
9.8
21
27
ZXD20
NOMESCO Finland
Day surgery
2.7
9.8
61
260
S01BA07
ATC
fluorometholone; ophthalmic
11.9
9.7
17
15
CHD65
NOMESCO Finland
Nonpenetrating glaucoma surgery
18.2
9.5
14
8
H17.8
ICD-10 Finland
Other corneal scars and opacities
+∞
9.4
9
*
CGG30
NOMESCO Finland
Anterior lamellar transplantation of cornea
+∞
9.4
9
*
CKD60
NOMESCO Finland
Anterior vitrectomy
12.0
9.2
16
14
H27.0
ICD-10 Finland
Aphakia
24.9
9.0
12
5
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
4.5
8.5
21
49
H17.9
ICD-10 Finland
Corneal scar and opacity, unspecified
+∞
8.4
8
*
3604
FHL
Penetration of the cornea
+∞
8.4
8
*
TCG30
NOMESCO Finland
Imaging of anterior and posterior part of cornea
+∞
8.4
8
*
3712A
ICD-9 Finland
Corneal opacity and other disorders of cornea, Corneal oedema
+∞
8.4
8
*
CGG99
NOMESCO Finland
Other reconstructive operations on cornea and sclera
+∞
8.4
8
*
S01CA02
ATC
prednisolone and antiinfectives; ophthalmic
17.8
8.1
12
7
S01ED02
ATC
betaxolol; ophthalmic
11.2
7.9
14
13
S01AX11
ATC
[U] ofloxacin
3.9
7.8
23
62
CFW99
NOMESCO Finland
Other operation on conjunctiva
18.9
7.7
11
6
XCH05
NOMESCO Finland
Eye pressure longterm registration
12.3
7.6
13
11
S01AA12
ATC
tobramycin; ophthalmic
81.9
7.4
8
*
CFD10
NOMESCO Finland
Repair of conjunctiva
81.9
7.4
8
*
CG2Z4
NOMESCO Finland
Specialised imaging of cornea
81.9
7.4
8
*
CJF20
NOMESCO Finland
Removal of artificial lens
81.9
7.4
8
*
H40.4
ICD-10 Finland
Glaucoma secondary to eye inflammation
81.9
7.4
8
*
CGD10
NOMESCO Finland
Laser keratoplasty for error of refraction
+∞
7.3
7
*
CGF10
NOMESCO Finland
Suture of laceration of cornea
+∞
7.3
7
*
CHW99
NOMESCO Finland
Other operation on anterior chamber, anterior chamber angle, iris or ciliary body
+∞
7.3
7
*
H18.9
ICD-10 Finland
Disorder of cornea, unspecified
+∞
7.3
7
*
S01XA03
ATC
sodium chloride, hypertonic; ophthalmic
+∞
7.3
7
*
T86.8
ICD-10 Finland
Failure and rejection of other transplanted organs and tissues
+∞
7.3
7
*
S01FA01
ATC
atropine; ophthalmic
20.6
7.2
10
5
S01BC05
ATC
ketorolac; ophthalmic
3.4
7.1
26
81
CHC05
NOMESCO Finland
Iridotomy
7.3
7.1
16
23
H33.0
ICD-10 Finland
Retinal detachment with retinal break
4.0
6.9
20
53
A04
ICPC
Weakness/tiredness general
2.2
6.7
64
327
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
3.1
6.7
28
95
S01BA01
ATC
dexamethasone; ophthalmic
4.2
6.7
18
45
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
5.9
6.5
17
30
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
7.7
6.5
14
19
H02.0
ICD-10 Finland
Entropion and trichiasis of eyelid
5.4
6.4
18
35
H27.1
ICD-10 Finland
Dislocation of lens
18.5
6.3
9
5
H16.1
ICD-10 Finland
Other superficial keratitis without conjunctivitis
+∞
6.3
6
*
H16.8
ICD-10 Finland
Other keratitis
+∞
6.3
6
*
3651A
ICD-9 Finland
Glaucoma, Open-angle glaucoma[GLAUCOMA SIMPLEX (AVOKULMA)]
27.3
6.3
8
*
CHD15
NOMESCO Finland
Trabeculectomy and iridectomy
12.9
6.1
10
8
S01XA18
ATC
ciclosporin; ophthalmic
12.9
6.1
10
8
CS434
NOMESCO Finland
Visual field testing with Humphrey automated perimetry
6.2
6.1
15
25
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
18
22
8.61
8.70
1.3
1.5
—
—
—
0
0
249
2013
2.13
6.99
4.4
4.4
14.92
15.03
pmol/l
0.27
227
1802
186
1366
1.88
6.88
2.5
2.2
93.87
96.28
pmol/l
0.26
94
691
185
1376
1.83
6.37
5.4
4.6
35.16
35.08
g/l
0.07
170
1289
121
791
1.86
6.34
2.6
2.2
3.04
3.09
mg/l
0.07
105
678
145
1009
1.81
6.16
4.1
3.3
6.48
7.09
mmol/l
1.16
125
844
186
1402
1.80
5.97
7.4
6.3
1.20
1.21
mmol/l
1.61
165
1286
300
2686
3.45
5.80
15.9
12.8
23.57
24.29
u/l
0.49
290
2602
216
1711
1.83
5.79
6.1
5.0
7.14
6.78
mmol/l
1.37
207
1637
277
2392
2.31
5.71
6.0
5.6
2.14
1.99
mu/l
1.32
255
2150
200
1553
1.79
5.68
8.6
7.1
1.21
1.21
mmol/l
0.61
171
1336
298
2667
3.17
5.59
29.5
22.3
139.37
139.55
mmol/l
0.49
293
2614
142
1009
1.74
5.43
4.8
4.1
11.27
9.68
mg/mmol
0.14
91
627
11
14
8.10
5.39
1.4
1.2
—
—
—
0
0
68
388
1.96
5.28
2.1
2.0
—
—
—
0
0
286
2526
2.44
5.19
5.8
5.4
4.44
4.52
mmol/l
0.69
263
2316
172
1303
1.70
5.11
2.9
2.5
78.79
79.06
nmol/l
0.04
156
1145
302
2746
3.42
5.03
36.8
27.7
245.41
244.11
e9/l
0.13
293
2693
302
2747
3.41
5.01
36.8
27.6
4.34
4.41
e12/l
1.61
293
2680
101
664
1.77
4.99
5.7
5.2
1.02
1.02
kg/l
0.19
74
451
288
2565
2.43
4.89
24.1
18.2
25.34
25.76
mg/l
0.08
249
2158
83
518
1.82
4.86
3.4
2.9
0.82
0.81
mmol/l
0.10
76
486
190
1492
1.69
4.82
5.2
4.6
0.00
10.52
estimate
0.80
35
333
89
573
1.77
4.68
1.9
1.7
1343.27
1225.31
nmol/l
0.49
62
437
249
2119
1.84
4.61
9.6
8.4
84.38
80.33
u/l
0.34
235
1995
240
2021
1.79
4.60
5.4
4.7
15.79
13.66
mm/h
1.18
223
1866
68
407
1.86
4.53
2.1
1.9
—
—
—
0
0
85
546
1.76
4.49
2.1
2.0
—
—
—
0
0
187
1480
1.65
4.45
5.0
4.5
0.00
0.00
estimate
-0.00
32
322
190
1511
1.65
4.42
5.4
4.6
0.00
0.97
estimate
0.51
32
312
287
2574
2.29
4.41
7.0
6.3
2.48
2.60
mmol/l
1.41
262
2348
282
2512
2.17
4.41
6.6
5.6
6.23
6.05
mmol/l
1.18
262
2274
128
934
1.62
4.14
2.6
2.1
151.99
209.99
u/l
0.98
122
885
129
947
1.61
4.05
1.9
1.8
22.85
21.14
nmol/l
0.47
112
786
20
76
2.74
3.98
2.0
1.5
—
—
—
0
0
280
2512
2.03
3.90
5.7
5.2
1.46
1.48
mmol/l
0.27
258
2288
276
2474
1.93
3.71
23.2
18.4
72.78
74.61
ml/min/173m2
0.70
259
2317
66
418
1.73
3.61
6.9
5.0
1.05
1.04
mmol/l
0.22
58
379
156
1222
1.55
3.58
3.8
3.1
142.08
132.91
ug/l
0.15
144
1119
90
621
1.63
3.56
5.9
4.1
342.84
221.35
ng/l
0.18
76
523
182
1482
1.54
3.46
20.5
15.1
1.36
1.29
inr
0.82
158
1237
55
335
1.78
3.43
9.1
8.7
—
—
—
0
0
269
2408
1.80
3.40
4.8
4.5
1.31
1.26
mmol/l
0.54
245
2166
62
392
1.72
3.40
5.4
6.8
0.73
1.18
mmol/l
0.50
47
330
188
1546
1.54
3.38
7.4
6.4
10.28
11.43
umol/l
1.21
179
1469
122
918
1.54
3.29
3.3
2.6
57.18
56.59
u/l
0.08
110
850
8
15
5.44
3.21
1.1
1.1
—
—
—
0
0
273
2470
1.79
3.12
8.6
7.1
42.02
40.07
mmol/mol
2.18
253
2289
73
493
1.63
3.11
3.1
2.5
2.36
2.29
g/l
0.57
68
453
52
322
1.74
3.07
2.3
2.7
5.76
7.58
umol/l
0.66
41
280
161
1300
1.49
3.03
3.2
2.7
—
—
estimate
—
0
0
76
522
1.60
3.02
3.4
2.5
11.93
12.20
umol/l
0.13
71
483
141
1112
1.49
2.97
1.9
1.9
1.33
1.29
mmol/l
0.38
121
920
191
1601
1.49
2.96
11.3
9.2
4.05
4.21
e9/l
0.50
164
1395
18
76
2.45
2.95
1.3
1.2
—
—
—
0
0
12
38
3.24
2.88
1.0
1.4
—
—
—
0
0
18
77
2.42
2.87
1.3
1.2
—
—
—
0
0
116
884
1.49
2.87
3.3
3.2
27.69
31.70
u/l
1.19
108
835
136
1071
1.47
2.86
3.5
3.3
2.35
2.36
mmol/l
0.21
129
958
136
1072
1.47
2.84
3.3
3.3
2241.02
1373.86
ng/l
1.04
119
925
90
653
1.53
2.80
1.9
1.8
86486899.99
453.72
pmol/l
0.49
74
527
40
236
1.80
2.78
3.1
3.2
62.74
57.18
ml/min/173m2
0.42
19
100
77
542
1.56
2.74
4.0
3.1
1.35
1.25
e6/l
0.10
48
292
113
874
1.46
2.54
4.2
3.4
0.53
0.59
e6/l
0.08
89
644
67
468
1.55
2.46
3.3
2.5
21.55
21.34
%
0.04
62
438
138
1122
1.41
2.32
5.2
4.7
0.00
0.06
estimate
1.87
25
268
127
1021
1.41
2.26
4.4
3.6
94.82
115.68
e6/l
0.10
104
784
28
159
1.84
2.22
1.4
1.4
—
—
—
0
0
10
36
2.83
2.15
1.6
3.4
—
1327.40
—
0
5
20
103
2.01
2.10
1.5
1.3
—
—
—
0
0
5
10
5.06
2.08
1.4
1.0
—
—
—
0
0
7
20
3.55
2.06
1.3
1.9
111.29
87.50
ng/l
—
7
20
188
1632
1.38
2.04
3.3
3.3
58.86
52.17
u/l
0.42
170
1512
37
236
1.64
1.98
1.8
1.5
—
—
—
0
0
7
22
3.23
1.89
1.3
1.3
98.43
102.82
pmol/l
—
7
22
145
1220
1.35
1.87
5.0
4.2
43.32
39.63
ng/l
0.10
112
951
40
269
1.56
1.74
2.7
2.6
29.06
32.61
u/l
0.52
35
225
105
855
1.34
1.64
5.8
4.6
0.00
0.01
estimate
0.50
32
291
13
63
2.11
1.62
1.5
1.6
—
—
—
0
0
40
274
1.53
1.62
5.3
3.0
66.19
66.69
g/l
0.14
33
255
46
325
1.49
1.61
3.4
3.3
1.84
2.09
mmol/l
0.22
40
278
66
503
1.39
1.55
4.3
3.3
1.86
3.22
e6/l
1.07
40
252
156
1352
1.30
1.55
2.5
2.7
—
—
—
0
0
88
710
1.33
1.45
2.4
2.2
—
—
—
0
0
16
88
1.86
1.44
1.6
1.5
48.33
10.79
u/ml
—
7
13
18
103
1.79
1.44
3.8
4.1
23.97
25.28
mmol/l
0.76
18
97
6
22
2.76
1.44
1.8
1.5
—
—
—
0
0
7
29
2.45
1.40
1.6
1.1
—
—
—
0
0
27
175
1.59
1.40
3.3
3.5
0.92
2.13
mmol/l
0.54
19
127
41
292
1.46
1.39
2.4
2.6
4.07
4.27
kpa
0.31
41
281
30
201
1.54
1.36
2.1
1.8
—
—
—
0
0
20
121
1.70
1.34
1.0
1.0
—
—
—
0
0
45
332
1.41
1.28
1.5
1.4
—
—
—
0
0
46
342
1.40
1.26
3.4
3.3
5.78
5.77
kpa
0.01
46
331
9
45
2.03
1.24
1.2
1.0
—
2.12
—
0
5
8
37
2.19
1.22
2.8
1.3
—
—
—
0
0
44
330
1.39
1.15
1.4
1.5
—
—
—
0
0
7
30
2.36
1.13
1.0
1.7
—
—
—
0
0
7
30
2.36
1.13
1.0
1.7
—
—
—
0
0
7
30
2.36
1.13
1.0
1.7
—
—
—
0
0
88
735
1.27
1.11
3.8
2.9
364.41
351.32
umol/l
0.42
75
634
14
81
1.76
1.11
2.8
2.9
0.00
1.72
index
—
6
46
8
41
1.98
1.09
1.3
1.6
—
—
—
0
0
25
170
1.51
1.08
2.3
2.6
—
17.92
—
0
9
73
597
1.29
1.08
1.3
1.3
3.82
1.51
u/ml
0.33
15
157
17
105
1.65
1.08
1.3
1.2
—
—
—
0
0
5
22
2.29
1.04
1.0
1.8
—
—
—
0
0
5
23
2.19
0.98
1.2
1.8
—
—
—
0
0
5
23
2.19
0.98
1.4
2.1
—
—
—
0
0
5
23
2.19
0.98
1.2
1.9
—
—
—
0
0
5
23
2.19
0.98
1.2
1.8
—
—
—
0
0
5
23
2.19
0.98
1.2
1.8
—
—
—
0
0
0
31
0.00
0.97
0.0
1.2
—
94.40
—
0
5
73
607
1.26
0.95
2.1
1.6
1.31
1.37
mg/l
0.09
57
493
30
219
1.41
0.93
7.8
8.2
1.09
1.39
%
1.27
30
219
13
78
1.70
0.93
1.1
1.6
—
—
—
0
0
6
28
2.16
0.92
1.0
1.7
—
—
—
0
0
6
28
2.16
0.92
1.0
1.7
—
—
—
0
0
31
229
1.39
0.91
1.7
1.8
1.53
1.54
%
0.03
26
194
6
29
2.09
0.90
1.0
1.7
—
—
—
0
0
16
103
1.58
0.89
5.7
4.0
2.15
3.69
ratio
—
10
57
35
265
1.36
0.89
3.8
3.6
103.82
84.72
ng/l
0.55
28
228
57
465
1.28
0.87
6.4
6.2
103.70
103.83
mmol/l
0.07
57
465
20
140
1.46
0.79
2.9
3.1
4.73
4.39
pmol/l
0.62
20
125
12
75
1.62
0.76
1.2
1.4
—
—
—
0
0
12
75
1.62
0.76
1.1
1.6
—
—
—
0
0
91
795
1.20
0.75
4.1
4.0
0.00
0.11
estimate
0.58
23
254
5
24
2.10
0.75
1.2
1.9
—
—
—
0
0
25
185
1.38
0.74
1.9
2.4
0.66
0.64
%
0.11
25
185
9
56
1.62
0.73
1.4
1.4
—
—
—
0
0
9
56
1.62
0.73
1.4
1.4
—
—
—
0
0
11
68
1.64
0.72
1.2
1.5
—
—
—
0
0
18
126
1.45
0.72
3.1
2.0
2.62
3.03
g/l
0.60
13
118
5
27
1.87
0.68
1.0
1.5
—
—
—
0
0
5
28
1.80
0.66
4.6
3.2
318.80
792.46
mg
—
5
28
44
361
1.25
0.66
3.4
4.2
3.47
37.79
ug/l
0.98
38
312
7
44
1.60
0.65
1.9
1.2
—
—
—
0
0
8
49
1.65
0.62
1.5
1.3
—
—
—
0
0
8
50
1.62
0.61
1.1
1.8
—
—
—
0
0
13
88
1.50
0.61
1.0
1.4
—
—
—
0
0
34
274
1.27
0.60
3.9
2.5
4.15
7.09
ug/l
1.32
27
245
5
89
0.55
0.56
1.0
1.2
—
29.86
—
0
5
8
55
1.47
0.56
6.8
3.0
13.29
9.19
pmol/l
—
8
55
6
38
1.59
0.54
1.8
2.4
108.00
106.00
mmol/l
—
6
38
6
38
1.59
0.54
1.8
2.4
1.20
1.19
mmol/l
—
6
38
9
61
1.49
0.54
1.4
2.6
—
—
—
0
0
9
62
1.46
0.53
1.3
1.1
—
—
—
0
0
6
39
1.55
0.53
1.3
3.4
—
29.39
—
0
18
6
39
1.55
0.53
1.0
1.5
—
—
—
0
0
11
77
1.44
0.46
1.3
1.7
6857.00
22381.41
e6/l
—
6
51
7
51
1.38
0.44
1.6
2.6
—
—
—
0
0
20
158
1.28
0.43
1.1
1.2
35.29
162.31
u/ml
—
7
53
8
57
1.41
0.42
1.0
1.6
—
—
—
0
0
8
58
1.39
0.42
1.0
1.6
—
—
—
0
0
0
15
0.00
0.41
0.0
1.4
—
—
—
0
0
0
17
0.00
0.41
0.0
1.6
—
—
—
0
0
0
17
0.00
0.41
0.0
1.6
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
12
88
1.38
0.40
4.8
2.0
0.26
0.41
iu/ml
—
7
52
5
35
1.44
0.39
1.0
1.2
—
—
—
0
0
5
36
1.40
0.38
1.0
1.3
—
—
—
0
0
6
41
1.47
0.36
1.3
1.3
—
—
—
0
0
6
41
1.47
0.36
1.2
1.9
—
—
—
0
0
91
843
1.11
0.34
6.0
5.8
1.73
2.64
ug/l
1.17
81
748
6
45
1.34
0.34
2.0
1.4
45.07
28.51
iu/l
—
6
39
13
101
1.30
0.32
3.8
4.0
3.92
3.90
mmol/l
0.09
13
101
7
53
1.33
0.31
1.1
1.1
1.86
15.30
e6/l
—
7
43
7
55
1.28
0.30
1.3
1.2
0.86
164.91
e6/l
—
7
45
9
116
0.77
0.28
2.0
1.8
—
—
—
0
0
10
128
0.77
0.27
2.1
1.9
—
—
—
0
0
14
113
1.25
0.27
2.9
3.1
—
—
—
0
0
8
66
1.22
0.27
1.0
1.6
—
—
—
0
0
9
77
1.17
0.24
1.6
1.7
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
27.76
—
0
10
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
29
259
1.13
0.21
7.2
4.2
1.21
1.23
mmol/l
0.88
24
224
6
52
1.16
0.19
1.5
1.5
173.17
238.21
pmol/l
—
6
47
10
82
1.23
0.17
1.4
1.5
—
—
—
0
0
5
70
0.71
0.17
1.2
1.3
—
—
—
0
0
71
676
1.06
0.15
4.9
4.8
20.22
21.78
%
0.44
32
341
9
83
1.09
0.15
2.4
1.3
—
—
—
0
0
35
328
1.08
0.11
3.6
3.6
—
—
—
0
0
37
349
1.07
0.10
5.2
5.1
30.12
32.05
%
0.39
16
219
5
61
0.82
0.08
1.2
1.2
0.82
0.87
g/l
—
5
61
5
60
0.83
0.08
1.2
1.2
1.39
1.55
g/l
—
5
60
48
498
0.96
0.07
3.5
3.2
0.75
0.87
ug/l
0.38
37
326
13
119
1.10
0.06
1.6
1.8
—
—
—
0
0
12
111
1.08
0.04
1.7
1.7
—
—
—
0
0
45
447
1.01
0.00
1.2
1.3
1.68
11.87
u/ml
2.13
17
156
50
503
0.99
0.00
1.3
1.3
25.23
39.94
iu/ml
0.96
11
163
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
1.19
—
0
5
24
240
1.00
-0.00
1.5
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
68.93
—
0
6
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
5
56
0.89
-0.00
1.4
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
11.29
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
0.42
—
0
6
0
7
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
63
0.95
-0.00
1.0
1.1
—
43.83
—
0
7
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
5
56
0.89
-0.00
1.4
1.3
—
180.00
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_CORNEALOEDEMA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CORNEALOEDEMA | 0.913 [0.77, 1.09] | 0.307 |
| Birth year | 0.991 [0.98, 1.0] | 0.037 |
During the follow-up period (1.1.1998 — 31.12.2019), 248 out of 903 females with H7_CORNEALOEDEMA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_CORNEALOEDEMA | 1.047 [0.8, 1.37] | 0.737 |
| Birth year | 0.987 [0.98, 1.0] | 0.007 |
During the follow-up period (1.1.1998 — 31.12.2019), 156 out of 602 males with H7_CORNEALOEDEMA died.
Mortality risk
Mortality risk for people of age
years, who have H7_CORNEALOEDEMA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.082% | 0.206% |
| 5 | 0.425% | 1.229% |
| 10 | 1.105% | 3.074% |
| 15 | 2.166% | 5.816% |
| 20 | 4.016% | 9.612% |
Relationships between endpoints
↥Index endpoint: H7_CORNEALOEDEMA – Other corneal oedema
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data