conjunctival scars

H7_CONJUNCTSCAR

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H11.2
  • Hospital discharge: ICD-9 3726
  • Hospital discharge: ICD-8 37821
  • Cause of death: ICD-10 H11.2
  • Cause of death: ICD-9 3726
  • Cause of death: ICD-8 37821

2 out of 7 registries used, show all original rules.

76

4. Check minimum number of events

None

76

5. Include endpoints

None

76

6. Filter based on genotype QC (FinnGen only)

67

Control definitions (FinnGen only)

Control exclude
H7_CONJUNCTIVA

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H11
Name in latin
Cicatrix/cicatrices conjunctivae

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 517 276 238
Only index persons 461 254 207
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 51.16 50.27 52.30
Only index persons 50.33 48.96 52.02

-FinnGen-

Key figures

All Female Male
Number of individuals 67 45 22
Unadjusted period prevalence (%) 0.01 0.02 0.01
Median age at first event (years) 50.86 50.57 51.45

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
68
Matched controls
680
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H11.2
ICD-10 Finland
Conjunctival scars
+∞
81.5
61
*
H04.10
ICD-10 Finland
Dry eye syndrome
6.8
10.9
21
42
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
5.2
10.5
38
133
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
5.1
9.6
46
198
CFD10
NOMESCO Finland
Repair of conjunctiva
+∞
9.6
9
*
H02.0
ICD-10 Finland
Entropion and trichiasis of eyelid
19.2
7.0
10
6
CFC00
NOMESCO Finland
Excision of lesion of conjunctiva
44.6
6.9
8
*
CBG00
NOMESCO Finland
Epilation of cilia by electrolysis
76.8
6.5
7
*
S01XA18
ATC
ciclosporin; ophthalmic
+∞
6.3
6
*
CFA20
NOMESCO Finland
Biopsy of conjunctiva
+∞
6.3
6
*

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
22
68
4.30
6.72
2.1
1.7
—
—
—
0
0
44
261
2.94
4.35
10.6
9.5
1.26
1.14
inr
0.70
37
209
18
81
2.66
2.85
2.3
2.0
—
—
—
0
0
32
197
2.18
2.49
7.3
7.2
—
—
—
0
0
27
159
2.16
2.32
3.7
4.5
—
—
—
0
0
20
104
2.31
2.31
4.2
3.4
20.92
92.53
ng/l
0.52
12
76
9
33
2.98
2.02
5.2
10.3
0.90
0.64
%
—
9
33
31
202
1.98
1.98
2.9
2.4
—
—
—
0
0
9
35
2.81
1.88
5.2
10.0
1.34
1.49
%
—
9
35
9
35
2.81
1.88
5.2
10.0
93.22
92.67
%
—
9
35
6
17
3.76
1.88
1.3
1.6
—
—
—
0
0
33
225
1.91
1.81
2.3
2.0
—
—
—
0
0
40
295
1.86
1.68
7.1
7.7
57.70
56.95
%
0.17
40
286
13
65
2.24
1.61
1.3
1.4
—
—
—
0
0
13
65
2.24
1.61
5.4
7.2
7.41
7.43
ph
—
7
40
45
350
1.84
1.54
9.8
10.9
4.44
3.84
e9/l
0.99
40
306
7
28
2.67
1.49
2.1
2.2
—
—
—
0
0
16
91
1.99
1.44
1.4
1.7
872.58
1148.21
nmol/l
—
10
71
5
17
3.09
1.38
1.2
1.5
—
—
—
0
0
38
288
1.72
1.36
3.1
2.7
—
—
estimate
—
0
0
8
34
2.53
1.34
7.8
12.1
25.26
25.76
mmol/l
—
8
34
11
56
2.15
1.30
1.6
1.2
—
—
—
0
0
6
25
2.53
1.27
5.3
2.4
25.72
23.71
mmol/l
—
6
25
5
19
2.76
1.24
1.6
1.2
—
—
—
0
0
13
74
1.94
1.16
3.6
9.0
105.77
104.07
mmol/l
0.71
13
74
40
318
1.63
1.12
6.7
7.3
0.06
0.04
e9/l
2.22
34
275
40
319
1.62
1.09
6.1
7.3
0.61
0.55
e9/l
1.35
34
278
25
178
1.64
1.08
5.2
7.9
—
—
—
0
0
7
35
2.11
1.03
2.7
3.7
—
—
—
0
0
9
50
1.92
1.01
7.0
10.3
—
—
—
0
0
7
36
2.05
1.00
4.0
6.2
127.00
131.00
g/l
—
7
36
40
325
1.56
0.97
6.7
7.3
1.87
1.81
e9/l
0.21
34
288
40
325
1.56
0.97
6.9
7.6
0.22
0.18
e9/l
0.57
34
287
60
542
1.91
0.97
4.0
4.0
1.29
1.26
mmol/l
0.09
50
504
8
45
1.88
0.88
1.6
1.9
—
—
—
0
0
13
83
1.70
0.82
1.6
1.6
—
—
—
0
0
18
126
1.58
0.81
1.7
1.9
1.95
1.06
mg/l
0.33
13
104
21
155
1.51
0.75
1.3
1.7
21.54
22.62
nmol/l
0.12
16
135
5
25
2.08
0.74
2.4
3.8
—
—
—
0
0
5
29
1.78
0.65
1.4
1.2
—
—
—
0
0
11
73
1.60
0.60
1.2
1.5
—
—
—
0
0
0
23
0.00
0.59
0.0
1.3
—
—
—
0
0
26
211
1.38
0.55
4.2
3.4
17.39
43.51
ng/l
0.77
15
149
30
250
1.36
0.54
2.2
1.9
1.38
1.23
mmol/l
0.56
24
210
61
572
1.64
0.54
5.3
4.7
1.50
1.50
mmol/l
0.00
54
534
61
574
1.61
0.54
5.2
4.8
4.78
4.66
mmol/l
0.37
54
537
24
196
1.35
0.48
4.2
3.3
—
—
—
0
0
10
69
1.53
0.47
1.5
1.3
—
—
—
0
0
5
32
1.61
0.43
1.6
1.4
0.21
0.23
g/l
—
5
32
5
32
1.61
0.43
1.6
1.4
1.27
1.21
g/l
—
5
32
5
32
1.61
0.43
2.2
6.8
0.64
0.59
%
—
5
32
5
32
1.61
0.43
2.4
6.9
0.62
1.25
%
—
5
32
0
16
0.00
0.41
0.0
3.1
—
66.84
—
0
16
15
116
1.38
0.41
1.5
1.7
—
—
—
0
0
0
18
0.00
0.40
0.0
8.1
—
—
—
0
0
17
135
1.35
0.40
1.9
1.8
—
—
—
0
0
20
240
0.76
0.40
3.8
3.0
—
—
—
0
0
0
19
0.00
0.39
0.0
1.3
—
—
—
0
0
0
19
0.00
0.39
0.0
1.1
—
—
—
0
0
50
461
1.32
0.39
11.0
8.5
86.84
80.58
u/l
0.41
50
432
15
187
0.75
0.39
5.3
3.0
—
—
—
0
0
25
212
1.28
0.38
3.3
2.9
7.08
8.26
mmol/l
0.75
20
173
15
118
1.35
0.37
1.5
1.3
1.03
3.30
u/ml
—
6
49
12
91
1.39
0.37
2.5
3.8
0.79
0.81
mmol/l
0.26
12
83
6
44
1.40
0.35
1.0
1.3
—
—
—
0
0
61
583
1.45
0.33
5.7
5.4
2.78
2.71
mmol/l
0.24
54
547
17
139
1.30
0.33
2.1
1.4
2.59
2.25
g/l
—
9
80
7
52
1.39
0.32
3.6
7.2
—
0.24
—
0
17
33
294
1.24
0.32
6.7
8.0
1.18
1.22
mmol/l
2.06
28
250
59
564
1.35
0.30
5.2
4.5
6.03
5.75
mmol/l
0.40
52
526
11
86
1.33
0.28
3.7
2.8
589.82
124.61
ug/g
0.51
11
65
14
114
1.29
0.28
2.9
2.9
2.45
2.44
mmol/l
0.04
14
102
22
192
1.22
0.25
1.3
1.5
—
—
—
0
0
15
177
0.80
0.24
3.9
4.0
0.00
0.00
estimate
—
6
67
28
252
1.19
0.23
2.0
2.0
81.00
93.18
pmol/l
0.65
14
120
22
194
1.20
0.22
2.8
2.7
58.68
75.18
u/l
0.26
22
181
10
80
1.29
0.22
1.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
2.2
—
—
—
0
0
22
195
1.19
0.21
3.5
3.1
31.26
40.45
mg/l
0.28
13
121
6
48
1.27
0.21
1.5
1.6
—
—
—
0
0
8
70
1.16
0.17
1.4
1.3
—
—
—
0
0
21
232
0.86
0.16
3.0
4.0
24.88
69.99
e6/l
0.59
15
162
10
83
1.24
0.16
1.4
1.2
—
—
—
0
0
57
553
1.19
0.14
6.6
5.7
39.95
38.60
mmol/mol
0.38
50
520
13
114
1.17
0.13
3.7
2.8
580.00
517.55
mosm/kgh2o
0.35
13
103
29
272
1.12
0.11
11.4
12.3
0.00
0.00
e9/l
0.71
22
225
5
45
1.12
0.10
6.0
3.1
—
—
—
0
0
6
57
1.06
0.09
4.5
2.5
6.08
6.24
ph
—
6
39
21
196
1.10
0.08
4.1
3.7
3.70
6.86
mg/mmol
0.73
13
119
6
72
0.82
0.08
1.5
1.4
—
—
—
0
0
31
324
0.92
0.07
5.0
4.0
0.00
0.00
estimate
—
7
71
11
99
1.13
0.07
2.9
2.9
0.89
0.69
ug/l
—
5
57
16
149
1.10
0.06
4.9
6.3
—
—
—
0
0
31
322
0.93
0.06
4.9
3.9
0.00
0.00
estimate
—
7
73
19
201
0.92
0.05
5.2
3.4
2.37
2.36
mmol/l
0.05
19
182
31
320
0.94
0.04
4.9
3.9
0.00
0.00
estimate
—
7
72
25
244
1.04
0.00
4.7
3.7
0.00
0.02
estimate
—
6
63
13
132
0.98
0.00
2.2
2.6
10.33
5.61
e6/l
0.40
13
123
26
257
1.02
0.00
3.5
3.4
6.03
6.19
ph
0.30
18
146
51
512
0.98
0.00
25.2
18.2
13.66
13.55
%
0.22
51
512
0
9
0.00
-0.00
0.0
2.9
—
5.85
—
0
9
0
6
0.00
-0.00
0.0
2.5
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.8
—
0.43
—
0
8
8
79
1.01
-0.00
1.6
1.6
—
—
—
0
0
6
69
0.86
-0.00
1.2
1.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
3.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.2
—
32.78
—
0
9
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
3.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.4
—
0.50
—
0
9
0
5
0.00
-0.00
0.0
3.2
—
6.60
—
0
5
0
5
0.00
-0.00
0.0
9.0
—
0.61
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.6
—
28.60
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
70.60
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
4.0
—
1.20
—
0
5
0
5
0.00
-0.00
0.0
1.6
—
27.28
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint H7_CONJUNCTSCAR and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have H7_CONJUNCTSCAR.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: H7_CONJUNCTSCAR – conjunctival scars

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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