Pupillary membranes and other adhesions and disruptions of iris and ciliary body

H7_ADHESIOIRIS

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — H21.4, H21.5 Hospital discharge: ICD-9 — 3647 Hospital discharge: ICD-8 — 37831 Cause of death: ICD-10 — H21.4, H21.5 Cause of death: ICD-9 — 3647 Cause of death: ICD-8 — 37831 2 out of 7 registries used, show all original rules.	88
4. Check minimum number of events None	88
5. Include endpoints None	88
6. Filter based on genotype QC (FinnGen only)	80

Control definitions (FinnGen only)

Control exclude: H7_SCLERACORNEA

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2

NAME	H7_ADHESIOIRIS
CONTROL_EXCLUDE	H7_SCLERACORNEA
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	H21[4-5]
HD_ICD_9	3647
HD_ICD_8	37831
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	H21[4-5]
COD_ICD_9	3647
COD_ICD_8	37831
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Pupillary membranes and other adhesions and disruptions of iris and ciliary body based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	849	383	459
Only index persons	678	307	371
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.01	0.01	0.01
Median age at first event (years)
Whole population	58.21	67.48	50.24
Only index persons	57.65	67.48	49.52

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	80	38	42
Unadjusted period prevalence (%)	0.02	0.01	0.02
Median age at first event (years)	68.56	70.09	67.17

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
81: Matched controls
810

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

H21.5

ICD-10 Finland

Other adhesions and disruptions of iris and ciliary body

+∞

70.4

Z96.1

ICD-10 Finland

Presence of intraocular lens

8.8

21.5

H21.4

ICD-10 Finland

Pupillary membranes

+∞

17.3

H20.0

ICD-10 Finland

Acute and subacute iridocyclitis

+∞

16.2

S01ED51

ATC

timolol, combinations; ophthalmic

9.1

15.8

H40.5

ICD-10 Finland

Glaucoma secondary to other eye disorders

50.9

11.3

H20.1

ICD-10 Finland

Chronic iridocyclitis

+∞

10.6

CJE20

NOMESCO Finland

Phakoemulsification with implantation of artificial lens in posterior chamber

4.8

10.6

246

S01CA01

ATC

dexamethasone and antiinfectives; ophthalmic

4.1

9.1

219

Z01.0

ICD-10 Finland

Examination of eyes and vision

4.3

7.7

114

Kela drug reimbursment

Glaucoma

4.9

7.7

H26.4

ICD-10 Finland

After-cataract

4.4

7.0

H40.20

ICD-10 Finland

Acute glaucoma with closed ventricular angle

75.6

6.5

S01ED01

ATC

timolol; ophthalmic

8.9

6.4

CHE30

NOMESCO Finland

Suture of iris

+∞

6.3

H25.1

ICD-10 Finland

Senile nuclear cataract

3.2

6.1

214

S05.1

ICD-10 Finland

Contusion of eyeball and orbital tissues

16.6

6.1

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3037522) Nuclear Ab [Titer] in Serum

3.02

3.68

1.7

1.4

440.00

594.29

titre

—

(3021347) Calcium.ionized [Moles/volume] in Serum or Plasma

286

2.29

3.29

6.1

6.6

1.23

1.20

mmol/l

1.16

260

(3013139) Helicobacter pylori Ag [Presence] in Stool

3.84

3.27

1.0

1.2

—

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

318

2.14

2.80

7.3

8.2

1.22

1.20

mmol/l

1.13

273

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

6.57

2.40

3.8

4.4

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

3.48

2.39

1.1

1.3

—

(3013707) Erythrocyte sedimentation rate [Velocity] in Red Blood Cells by Westergren method

451

2.13

2.37

6.8

4.4

15.76

12.75

mm/h

0.61

416

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

4.15

2.31

1.1

—

(3007853) Bacteria identified in Skin by Aerobe culture

2.41

2.27

1.6

1.7

—

(3023368) Bacteria identified in Blood by Culture

208

1.99

2.26

3.7

4.3

—

(3003396) Base excess in Arterial blood by calculation

2.33

2.21

6.1

7.8

0.03

0.76

mmol/l

0.33

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

113

2.16

2.17

2.0

2.8

1.71

1.25

e6/l

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

106

2.18

2.15

2.1

3.0

0.68

3.08

e6/l

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

2.74

2.11

1.5

1.4

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

267

1.89

2.06

2.3

2.2

103.87

95.79

pmol/l

0.37

130

(3019977) pH of Arterial blood

2.24

2.03

6.1

7.6

7.39

7.42

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

2.67

2.03

1.2

2.1

—

(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma

2.39

2.02

3.4

2.0

6.67

7.07

umol/l

—

(3018418) pH of Serum or Plasma

201

1.88

1.90

2.5

4.4

7.40

7.39

0.07

149

(3004588) Protein electrophoresis panel - Serum or Plasma

2.55

1.87

1.8

2.9

—

(3032080) INR in Blood by Coagulation assay

330

1.82

1.85

19.2

13.2

1.37

1.27

inr

0.51

277

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

2.95

1.85

1.1

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

3.51

1.78

1.2

1.1

—

(42529406) Shigella sp [Presence] in Stool by Culture

3.51

1.78

1.2

1.1

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

3.51

1.78

1.2

1.1

—

(3015736) pH of Urine

268

1.79

1.76

3.2

3.6

6.40

6.14

0.84

144

(3026008) Bacteria identified in Urine by Culture

189

1.83

1.73

3.3

3.2

—

(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis

3.32

1.69

1.0

1.1

0.00

g/l

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

132

1.92

1.68

1.5

1.3

0.80

1.50

u/ml

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

2.39

1.65

1.2

2.3

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

2.19

1.59

1.9

1.6

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

151

1.84

1.59

2.4

2.2

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

3.26

1.46

2.2

1.3

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

3.26

1.46

1.0

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

3.26

1.46

2.2

1.3

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.99

1.43

1.9

1.6

—

(36660697) Celiac disease serology panel - Serum

2.29

1.40

1.4

1.3

—

(3021601) Nitrite [Presence] in Urine by Test strip

339

1.65

1.39

4.6

4.0

0.00

estimate

-0.00

(3015377) Calcium [Moles/volume] in Serum or Plasma

218

1.68

1.39

4.7

3.6

2.39

2.35

mmol/l

0.80

198

(3008898) HLA-B27 [Presence]

3.06

1.38

1.4

1.1

—

(3035350) Ketones [Presence] in Urine by Test strip

340

1.64

1.36

4.5

4.0

0.00

estimate

-0.00

(36304419) Bacteria [Presence] in Urine

185

1.69

1.32

1.9

3.3

—

estimate

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

267

1.63

1.30

3.1

2.8

74.03

76.60

nmol/l

0.28

239

(3031040) Bacteria [#/volume] in Urine by Automated count

425

1.62

1.24

5.8

4.6

—

220.00

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

2.16

1.19

1.6

3.4

49.80

46.69

—

(3009261) Glucose [Presence] in Urine by Test strip

348

1.58

1.19

4.5

4.0

0.00

estimate

-0.00

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.81

1.17

1.6

1.7

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.11

1.16

1.3

1.6

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.80

1.10

1.7

1.9

—

(3002582) Erythrocytes [#/volume] in Urine

230

1.56

1.08

2.5

3.5

17.73

346.18

e6/l

0.61

175

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

221

1.57

1.08

3.0

3.5

881.21

1831.71

ng/l

1.63

189

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

108

1.73

1.07

1.6

1.2

9.50

36.95

iu/ml

—

(3006923) Alanine aminotransferase [Enzymatic activity/volume] in Serum or Plasma

642

1.86

1.01

14.5

11.4

25.12

26.61

u/l

0.34

628

(3019060) Gas panel - Arterial blood

1.90

1.00

2.4

4.0

—

(3041096) Erythrocytes [Presence] in Urine by Automated

197

1.56

1.00

4.1

3.6

0.00

estimate

—

(3030467) Casts [#/volume] in Urine by Automated count

198

1.55

0.98

2.3

3.3

0.09

0.37

e6/l

1.95

145

(3044640) Blood type and Crossmatch panel - Blood

199

1.54

0.96

2.5

2.2

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.71

0.96

1.7

1.9

—

(3025941) Bacteria identified in Stool by Culture

2.23

0.93

1.5

1.2

—

(3020682) Albumin/Creatinine [Ratio] in Urine

209

1.52

0.93

4.6

3.8

12.54

9.49

mg/mmol

0.15

142

(40761511) CBC panel - Blood by Automated count

635

1.75

0.92

18.3

15.1

—

(3019832) Treponema pallidum Ab [Presence] in Serum

2.00

0.92

1.4

1.7

—

(3018095) Leukocytes [#/volume] in Urine

257

1.48

0.90

2.9

4.2

174.94

117.26

e6/l

0.13

182

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.67

0.89

1.6

1.9

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

239

1.48

0.88

2.3

3.4

—

(42870588) Differential panel, method unspecified - Blood

221

1.49

0.87

7.9

5.7

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

445

1.47

0.86

6.2

4.3

14.67

15.08

pmol/l

0.65

399

(3042936) Bacteria identified in Isolate by Culture

1.65

0.86

2.4

2.1

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

281

1.43

0.80

3.8

4.4

24.10

28.47

ng/l

0.29

217

(3008037) Lactate [Moles/volume] in Venous blood

2.25

0.77

1.6

2.8

1.74

1.36

mmol/l

—

(3015235) Bicarbonate [Moles/volume] in Capillary blood

2.25

0.77

5.2

2.4

22.80

24.65

mmol/l

—

(3001334) Neutrophil cytoplasmic Ab [Units/volume] in Serum

2.25

0.77

1.0

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.71

0.77

1.9

1.5

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.71

0.76

1.2

1.3

—

(3012516) Albumin [Mass/volume] in Urine

208

1.45

0.76

3.7

3.3

46.69

60.37

mg/l

0.18

141

(3029937) Albumin [Presence] in Urine by Test strip

182

1.45

0.73

5.5

4.1

0.00

0.03

estimate

—

(3022145) Colonoscopy Study observation

1.69

0.73

1.3

1.2

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

1.69

0.69

1.6

1.8

—

(3004410) Hemoglobin A1c/Hemoglobin.total in Blood

572

1.46

0.66

7.2

6.6

40.36

40.23

mmol/mol

0.03

528

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

617

1.50

0.63

23.4

16.4

26.46

25.94

mg/l

0.05

512

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

262

1.37

0.63

4.8

3.9

0.00

0.07

estimate

0.78

(3007164) IgA [Mass/volume] in Serum or Plasma

115

1.49

0.62

1.9

1.4

2.31

2.40

g/l

—

(40768797) Stomach Pathology biopsy report

1.55

0.62

1.2

1.1

—

(3036481) Cortisol [Moles/volume] in Serum or Plasma

1.64

0.62

1.4

1.7

432.60

411.55

nmol/l

—

(3000494) Fungus identified in Specimen by Culture

1.51

0.55

1.7

1.5

—

(3021589) Normoblasts [#/volume] in Blood

305

1.32

0.55

11.1

13.3

0.00

e9/l

-0.00

244

(3023520) Reticulocytes [#/volume] in Blood

1.46

0.54

10.0

3.8

79.92

69.94

e9/l

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

128

1.42

0.53

1.6

1.9

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

260

1.31

0.50

2.0

1.9

1.37

1.47

mmol/l

0.31

217

(3006315) Basophils [#/volume] in Blood

338

1.30

0.50

7.9

6.2

0.04

e9/l

0.17

289

(3002256) Pathology report gross observation

1.50

0.48

1.3

—

(3005322) IgE [Units/volume] in Serum or Plasma

1.50

0.48

1.1

1.2

115.57

514.80

u/ml

—

(3013115) Eosinophils [#/volume] in Blood

350

1.28

0.47

7.4

6.6

0.24

0.19

e9/l

1.42

305

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.44

0.46

1.6

1.7

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

244

1.29

0.45

4.8

1.65

2.02

ug/l

0.35

222

(3019198) Lymphocytes [#/volume] in Blood

342

1.27

0.44

7.9

6.3

1.84

1.82

e9/l

0.04

303

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

546

1.30

0.42

7.4

5.3

2.12

1.97

mu/l

0.44

491

(3000492) Spirometry study

1.39

0.40

1.4

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

0.64

0.38

4.2

3.3

—

(3001604) Monocytes [#/volume] in Blood

338

1.23

0.36

7.7

6.2

0.61

0.59

e9/l

0.21

289

(40764999) Glomerular filtration rate [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)/1.73 sq M

594

1.27

0.33

21.9

16.7

74.45

76.83

ml/min/173m2

0.38

554

(1761868) Lipid panel - Serum or Plasma

236

0.80

0.32

3.4

3.0

—

(3013650) Neutrophils [#/volume] in Blood by Automated count

381

1.21

0.32

10.1

9.8

4.30

4.12

e9/l

0.16

332

(3017732) Neutrophils [#/volume] in Blood

1.36

0.32

4.0

2.9

4.13

7.24

e9/l

0.58

(3000991) Gas panel - Venous blood

1.30

0.31

11.0

9.2

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

286

1.20

0.28

3.3

2.7

—

estimate

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

0.65

0.27

4.4

8.5

—

(40758558) Short blood count panel - Blood

210

1.20

0.26

6.0

5.9

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

611

1.23

0.25

6.2

5.9

2.51

2.66

mmol/l

0.65

559

(3003694) ABO and Rh group [Type] in Blood

154

1.22

0.23

2.1

1.4

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

1.27

0.23

1.6

2.5

0.70

0.63

—

(44790048) Parainfluenza type 2 nucleic acid detection

0.00

0.21

0.0

1.5

—

(44790049) Parainfluenza type 3 nucleic acid detection

0.00

0.21

0.0

1.5

—

(44806118) Parainfluenza type 4 nucleic acid detection

0.00

0.21

0.0

1.5

—

(3026389) Candida sp identified in Specimen by Organism specific culture

0.00

0.21

0.0

1.2

—

(3012441) Differential panel - Pleural fluid

0.00

0.21

0.0

1.8

—

(44790047) Parainfluenza type 1 nucleic acid detection

0.00

0.21

0.0

1.5

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.21

0.0

1.4

—

(3010726) Horse dander IgE Ab [Units/volume] in Serum

0.00

0.21

0.0

1.0

—

0.52

—

(3052649) Adenosine deaminase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.21

0.0

1.9

—

11.80

—

(3020148) Glutamate decarboxylase 65 Ab [Units/volume] in Serum

0.00

0.21

0.0

1.0

—

(3036428) Adenosine deaminase [Enzymatic activity/volume] in Pleural fluid

0.00

0.21

0.0

1.4

—

11.60

—

(40768806) Pleura Pathology biopsy report

0.00

0.21

0.0

1.8

—

(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction

0.00

0.21

0.0

1.5

—

162.55

—

(3028707) Methadone [Presence] in Urine by Screen method

0.00

0.21

0.0

1.3

—

(3035715) Granulocytes [#/volume] in Blood

0.00

0.21

0.0

2.2

—

4.85

—

(3008401) Mugwort IgE Ab [Units/volume] in Serum

0.00

0.21

0.0

1.0

—

1.30

—

(3003888) Timothy IgE Ab [Units/volume] in Serum

0.00

0.20

0.0

1.0

—

2.89

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

575

1.17

0.19

4.2

1.33

1.28

mmol/l

0.25

516

(4035726) Immunohistochemistry procedure

1.18

0.18

1.0

1.3

—

(3013512) EKG study

234

0.86

0.18

4.4

4.1

—

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

597

1.16

0.17

5.4

5.1

1.40

1.43

mmol/l

0.25

542

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

191

1.13

0.13

3.2

4.5

13.97

22.18

—

(40768804) Tissue Pathology biopsy report

250

1.12

0.13

1.8

2.1

—

(3019900) Cholesterol [Moles/volume] in Serum or Plasma

601

1.13

0.13

5.4

5.1

4.40

4.53

mmol/l

0.42

548

(3014576) Chloride [Moles/volume] in Serum or Plasma

105

1.17

0.12

12.1

6.3

104.25

104.45

mmol/l

0.07

105

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

372

1.09

0.10

2.3

3.0

—

(40761536) Microorganisms panel - Urine sediment

1.12

0.09

5.7

4.3

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

586

1.09

0.08

6.0

5.1

6.10

6.01

mmol/l

0.18

530

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

152

1.07

0.02

2.2

2.8

0.36

0.80

ug/l

—

(40760892) CBC W Ordered Manual Differential panel - Blood

145

1.04

0.00

6.0

5.8

—

(3024522) Salmonella sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.6

—

(3042975) Streptococcus sp identified in Isolate by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

0.00

-0.00

0.0

1.3

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

4.9

—

3.11

—

(37208534) Antinuclear antibody arbitrary concentration in serum

0.00

-0.00

0.0

1.0

—

(3023511) Choriogonadotropin [Units/volume] in Urine

0.00

-0.00

0.0

1.6

—

(3020717) Zinc [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

2.0

—

12.44

—

(3044290) Cell count panel - Cerebral spinal fluid

0.00

-0.00

0.0

1.3

—

(3030692) Respiratory virus DNA+RNA [Identifier] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.3

—

(3028167) CD3+CD4+ (T4 helper) cells [#/volume] in Blood

0.00

-0.00

0.0

2.6

—

0.38

—

(3011648) Oxygen content in Venous blood

0.00

-0.00

0.0

2.9

—

11.66

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.00

-0.00

0.0

1.0

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.5

—

(3017569) Oxygen content in Arterial blood

0.00

-0.00

0.0

11.4

—

14.60

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

-0.00

0.0

1.1

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

27.8

—

1271.00

—

(3012568) Campylobacter sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.6

—

(3051014) Leukocytes [#/area] in Urine sediment by Automated count

0.00

-0.00

0.0

1.8

—

(3025468) Yersinia sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.6

—

(3022806) Fractional oxyhemoglobin in Capillary blood

0.00

-0.00

0.0

1.7

—

89.11

—

(3004451) EKG impression Narrative

0.00

-0.00

0.0

1.6

—

(3011544) Albumin [Mass/volume] in Pleural fluid

0.00

-0.00

0.0

1.0

—

18.60

—

(21494815) CD4 cells/Lymphocytes in Specimen

0.00

-0.00

0.0

2.6

—

46.06

—

(40764127) Haemophilus influenzae DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(3001788) Aldosterone [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

253.29

—

(3049714) Procollagen type I.N-terminal propeptide [Mass/volume] in Serum

0.00

-0.00

0.0

1.8

—

71.45

—

(3000093) Morphology [Interpretation] in Blood Narrative

0.00

-0.00

0.0

1.4

—

(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.0

—

(3045788) Cell count panel - Pleural fluid

0.00

-0.00

0.0

1.4

—

(42868716) Shigella species+EIEC invasion plasmid antigen H ipaH gene [Presence] in Stool by NAA with probe detection

0.00

-0.00

0.0

1.6

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

-0.00

0.0

1.2

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

-0.00

0.0

1.5

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

22.0

—

802.50

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

-0.00

0.0

1.0

—

Mortality – FinRegistry

↥

Association

Association between endpoint H7_ADHESIOIRIS and mortality.

Females

Parameter	HR [95% CI]	p-value
H7_ADHESIOIRIS	1.018 [0.78, 1.33]	0.893
Birth year	0.993 [0.98, 1.0]	0.116

During the follow-up period (1.1.1998 — 31.12.2019), 89 out of 298 females with H7_ADHESIOIRIS died.

Males

Parameter	HR [95% CI]	p-value
H7_ADHESIOIRIS	1.279 [0.92, 1.78]	0.144
Birth year	0.987 [0.98, 1.0]	0.014

During the follow-up period (1.1.1998 — 31.12.2019), 79 out of 348 males with H7_ADHESIOIRIS died.

Mortality risk

Mortality risk for people of age

years, who have H7_ADHESIOIRIS.

N-year risk	Females	Males
1	0.083%	0.236%
5	0.665%	1.563%
10	1.45%	3.976%
15	2.724%	7.568%
20	4.764%	12.717%

Relationships between endpoints

↥

Index endpoint: H7_ADHESIOIRIS – Pupillary membranes and other adhesions and disruptions of iris and ciliary body

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Pupillary membranes and other adhesions and disruptions of iris and ciliary body

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints