tarsal tunnel syndrome: Tarsal tunnel syndrome is a nerve disorder that is characterized by pain in the ankle, foot, and toes. This condition is caused by compression of the posterior tibial nerve, which runs through a canal near the heel into the sole of the foot. When tissues around this nerve become inflamed, they can press on the nerve and cause the pain associated with tarsal tunnel syndrome.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
416 |
4. Check minimum number of eventsNone |
416 |
5. Include endpointsNone |
416 |
6. Filter based on genotype QC (FinnGen only) |
373 |
Control definitions (FinnGen only)
- Control exclude
- G6_NERPLEX
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- G57
- Name in latin
- Syndroma canalis tarsi
Similar endpoints
↥List of similar endpoints to
Tarsal tunnel syndrome
based on the number of shared cases.
Similar with more cases:
- Nerve, nerve root and plexus disorders
- Neurological diseases
- Neurological diseases, wide definition
- Any prescribed medicine buy
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2313 | 1573 | 732 |
| Only index persons | 2188 | 1518 | 670 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.05 | 0.02 |
| Only index persons | 0.05 | 0.06 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 50.86 | 51.67 | 49.08 |
| Only index persons | 50.63 | 51.61 | 48.43 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 373 | 283 | 90 |
| Unadjusted period prevalence (%) | 0.09 | 0.10 | 0.04 |
| Median age at first event (years) | 51.83 | 51.50 | 52.87 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 385
- Matched controls
- 3850
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G57.5
ICD-10 Finland
Tarsal tunnel syndrome
+∞
307.7
340
*
ACC59
NOMESCO Finland
Decompression and freeing of adhesions of peripheral nerve: other or unspecified
461.0
132.3
125
*
G56.0
ICD-10 Finland
Carpal tunnel syndrome
17.0
97.1
88
66
3555A
ICD-9 Finland
Mononeuritis of lower limb, Tarsal tunnel syndrome
+∞
56.7
53
*
N03AX16
ATC
[U] pregabalin
4.7
48.2
164
521
2402
FHL
External neurolysis of the nerve and possible alteration of the pathway (nerve pressure)
186.5
48.1
49
*
ACC51
NOMESCO Finland
Release of median nerve
491.9
45.2
44
*
N03AX12
ATC
[U] gabapentin; oral
5.0
43.2
121
326
M72.2
ICD-10 Finland
Plantar fascial fibromatosis
4.9
31.2
79
192
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
6.0
30.4
59
113
N02AX02
ATC
tramadol; systemic, rectal
3.3
28.8
222
1131
ACC55
NOMESCO Finland
Release of tibial nerve
+∞
28.5
27
*
G57.6
ICD-10 Finland
Lesion of plantar nerve
23.9
26.2
37
17
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.7
24.4
92
298
M54.4
ICD-10 Finland
Lumbago with sciatica
3.4
24.1
112
415
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.9
23.7
220
1203
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
3.7
23.6
89
288
M79.6
ICD-10 Finland
Pain in limb
3.0
23.6
235
1334
N06AX21
ATC
duloxetine; oral
3.8
22.7
82
257
M21.4
ICD-10 Finland
Flat foot [pes planus] (acquired)
6.7
21.9
36
58
M77.4
ICD-10 Finland
Metatarsalgia
4.7
21.6
55
133
L16
ICPC
Ankle symptom/complaint
3.5
21.0
84
281
L17
ICPC
Foot/toe symptom/complaint
2.7
19.7
167
850
M19.0
ICD-10 Finland
Primary arthrosis of other joints
3.6
19.2
72
230
M25.5
ICD-10 Finland
Pain in joint
2.6
18.5
178
958
M01AC06
ATC
meloxicam; systemic, rectal
2.6
18.4
189
1049
L03
ICPC
Low back symptom/complaint
2.6
16.9
149
762
M01AH05
ATC
etoricoxib; oral
2.7
16.6
283
1954
M01AH02
ATC
rofecoxib; oral
3.2
16.3
77
283
N06AA09
ATC
amitriptyline; systemic
3.5
15.8
59
187
M01AH03
ATC
valdecoxib; oral
4.5
15.8
41
100
M17.1
ICD-10 Finland
Other primary gonarthrosis
2.6
15.4
119
567
A02BC03
ATC
lansoprazole; oral
2.4
14.6
144
765
M77.1
ICD-10 Finland
Lateral epicondylitis
3.7
14.1
48
143
NH1CG
NOMESCO Finland
Ankle and foot extensive MRI examination with high intensity magnet
18.4
14.0
21
12
M01AE03
ATC
ketoprofen; systemic, rectal
2.3
14.0
174
1019
M03BX02
ATC
tizanidine; oral
2.4
13.9
272
1922
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.3
13.8
170
990
M54.5
ICD-10 Finland
Low back pain
2.3
13.8
172
1007
M01AB05
ATC
diclofenac; systemic, rectal
2.5
13.7
287
2084
M48.0
ICD-10 Finland
Spinal stenosis
3.1
13.6
65
239
M02AA07
ATC
piroxicam; topical
2.3
13.6
172
1011
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
3.3
13.5
55
184
M01AX17
ATC
nimesulide; oral
2.4
13.3
121
617
NHL50
NOMESCO Finland
Tenolysis or tenosynovectomy of foot
29.5
13.1
17
6
A02BC02
ATC
pantoprazole; systemic
2.5
12.8
295
2197
Z01.8
ICD-10 Finland
Other specified special examinations
2.4
12.2
107
534
NGA30
NOMESCO Finland
Exploration of knee joint, arthroscopic
4.3
12.1
32
79
A01
ICPC
Pain general/multiple sites
2.9
12.1
63
243
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
3.9
12.1
37
102
H02AB06
ATC
prednisolone; systemic
2.1
12.0
206
1347
M70.6
ICD-10 Finland
Trochanteric bursitis
2.6
12.0
84
378
E66.8
ICD-10 Finland
Other obesity
4.0
11.7
35
95
XA402
NOMESCO Finland
ENMG
9.7
11.7
23
25
L08
ICPC
Shoulder symptom/complaint
2.3
11.5
110
568
NHM10
NOMESCO Finland
Fasciotomy of ankle or foot
20.8
11.2
16
8
M01AB55
ATC
diclofenac, combinations; oral
3.4
11.2
42
133
N02BF01
ATC
gabapentin; oral
3.0
11.0
54
201
M01AX05
ATC
glucosamine; oral
2.3
10.7
103
531
NH1BG
NOMESCO Finland
Ankle and foot MRI examination with high intensity magnet
8.9
10.7
22
26
M75.1
ICD-10 Finland
Rotator cuff syndrome
2.2
10.5
121
672
M79.0
ICD-10 Finland
Rheumatism, unspecified
4.5
10.5
26
61
NGF25
NOMESCO Finland
Operation for osteochondritis of knee, arthroscopic
3.5
10.4
37
113
M54.1
ICD-10 Finland
Radiculopathy
4.4
10.3
26
62
M01AH01
ATC
celecoxib; oral
2.3
10.0
89
443
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.8
10.0
52
200
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
2.8
9.8
53
208
N02AJ06
ATC
codeine and paracetamol; systemic
2.0
9.8
185
1225
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
2.8
9.7
53
209
ACC19
NOMESCO Finland
Transcision of peripheral nerve: other or unspecified
102.5
9.5
10
*
M01AE02
ATC
naproxen; oral, rectal
2.0
9.4
239
1743
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.5
9.4
67
302
N06AX16
ATC
venlafaxine; oral
2.4
9.4
71
329
H02BX01
ATC
methylprednisolone, combinations; systemic
3.6
9.3
31
91
M67.4
ICD-10 Finland
Ganglion
3.0
9.1
42
151
D07AC01
ATC
betamethasone; topical
2.0
9.0
156
996
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.3
8.7
74
360
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
2.4
8.7
64
292
R06.0
ICD-10 Finland
Dyspnoea
2.0
8.6
123
732
M79.7
ICD-10 Finland
Fibromyalgia
4.1
8.6
24
62
WX320
NOMESCO Finland
Spinalanesthesy
2.0
8.5
115
670
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.0
8.5
130
792
G57.8
ICD-10 Finland
Other mononeuropathies of lower limb
92.0
8.4
9
*
M19.1
ICD-10 Finland
Post-traumatic arthrosis of other joints
4.8
8.4
19
41
M02AA10
ATC
ketoprofen; topical
2.3
8.4
75
372
G57.4
ICD-10 Finland
Lesion of medial popliteal nerve
+∞
8.4
8
*
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.4
8.2
59
266
F32.11
ICD-10 Finland
Moderate depressive episode with somatic syndrome
4.9
8.2
18
38
M76.6
ICD-10 Finland
Achilles tendinitis
3.3
8.2
31
99
J01DA01
ATC
[U] cefalexin
1.9
8.1
254
1940
ZXA00
NOMESCO Finland
Right side
2.0
8.1
116
688
R52.2
ICD-10 Finland
Other chronic pain
4.0
8.1
23
60
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
3.1
8.0
34
116
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.5
8.0
52
224
M77.0
ICD-10 Finland
Medial epicondylitis
4.8
8.0
18
39
M22.4
ICD-10 Finland
Chondromalacia patellae
4.8
8.0
18
39
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.8
8.0
187
1303
M54.3
ICD-10 Finland
Sciatica
3.4
7.8
29
91
A02BA02
ATC
ranitidine; systemic
2.1
7.8
86
464
NJ2MA
NOMESCO Finland
Measurement of mechanical axis of lower leg with X-ray
2.9
7.8
38
141
A02BC05
ATC
esomeprazole; systemic
1.8
7.7
171
1168
NHU20
NOMESCO Finland
Removal of internal fixation device from ankle or foot
3.4
7.7
28
87
N03AX09
ATC
lamotrigine; oral
3.6
7.7
25
72
J01AA02
ATC
doxycycline; systemic
2.1
7.6
315
2613
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
2.0
7.6
103
599
N02BF02
ATC
pregabalin; oral
3.0
7.5
35
126
J01DB01
ATC
cefalexin; oral
2.2
7.5
327
2757
M47.9
ICD-10 Finland
Spondylosis, unspecified
6.7
7.5
18
28
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
2.4
7.5
57
264
N02AA05
ATC
oxycodone; systemic
2.1
7.4
77
405
L11
ICPC
Wrist symptom/complaint
2.7
7.4
42
169
A02BA03
ATC
famotidine; systemic
4.3
7.4
19
46
M65.9
ICD-10 Finland
Synovitis and tenosynovitis, unspecified
4.3
7.4
19
46
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
2.9
7.3
35
128
R09
ICPC
Sinus symptom/complaint
2.6
7.3
45
188
G51.0
ICD-10 Finland
Bell palsy
+∞
7.3
7
*
M75.4
ICD-10 Finland
Impingement syndrome of shoulder
3.0
7.3
33
117
M76.8
ICD-10 Finland
Other enthesopathies of lower limb, excluding foot
4.4
7.3
18
42
M01AC01
ATC
piroxicam; systemic, rectal
2.3
7.3
61
294
J01FA10
ATC
azithromycin; systemic
1.8
7.2
238
1819
L86
ICPC
Back syndrome with radiating pain
3.0
7.1
31
108
N02BE01
ATC
paracetamol; systemic, rectal
2.8
7.0
356
3136
A02BC01
ATC
omeprazole; systemic
1.9
7.0
110
669
NBG15
NOMESCO Finland
Acromioplastia, arthroscopic
3.1
7.0
30
103
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.9
7.0
116
719
M01AX01
ATC
nabumetone; oral
3.4
7.0
25
77
N06AB03
ATC
fluoxetine; oral
2.2
6.9
61
300
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.9
6.9
109
664
SPAT1216
SPAT
Assessment of functional ability
2.1
6.8
69
359
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.8
6.8
193
1403
H01
ICPC
Ear pain/earache
2.3
6.8
53
248
ABC36
NOMESCO Finland
Decompression of lumbar nerve roots
3.4
6.7
24
74
M03BA52
ATC
carisoprodol, combinations excl. psycholeptics; oral
3.5
6.7
23
69
EB1AA
NOMESCO Finland
Intraoral radiographic dental examination
1.7
6.6
218
1647
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
2.1
6.6
71
378
X59
ICD-10 Finland
Exposure to unspecified factor
2.0
6.6
78
430
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
2.6
6.6
38
154
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.8
6.6
120
764
R01BA52
ATC
pseudoephedrine, combinations; oral
1.8
6.5
132
866
ZXD20
NOMESCO Finland
Day surgery
2.2
6.5
60
300
M03BC51
ATC
orphenadrine, combinations; systemic
1.8
6.5
122
782
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
2.5
6.5
43
186
ZA7.0
ICD-10 Finland
Ankle and foot
7.6
6.5
14
19
TAB20
NOMESCO Finland
Epidural puncture
14.6
6.4
10
7
G50.1
ICD-10 Finland
Atypical facial pain
14.6
6.4
10
7
NGD05
NOMESCO Finland
Partial excision of meniscus of knee, arthroscopic
2.3
6.4
51
240
L28
ICPC
Limited function/disability (L)
1.9
6.4
86
496
L90
ICPC
Osteoarthrosis of knee
2.6
6.3
38
157
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.7
6.3
33
127
ZXA05
NOMESCO Finland
Left side
1.9
6.3
100
609
G57.9
ICD-10 Finland
Mononeuropathy of lower limb, unspecified
+∞
6.3
6
*
3540A
ICD-9 Finland
Mononeuritis of upper limb and mononeuritis multiplex, Carpal tunnel syndrome
+∞
6.3
6
*
A04
ICPC
Weakness/tiredness general
2.1
6.2
66
349
M79.2
ICD-10 Finland
Neuralgia and neuritis, unspecified
5.5
6.2
17
32
M54
ICD-10 Finland
Dorsalgia
2.2
6.2
53
257
M19.8
ICD-10 Finland
Other specified arthrosis
3.0
6.2
27
94
SPAT1153
SPAT
Removal of sutures
1.8
6.2
125
819
R06AX27
ATC
desloratadine; oral
1.8
6.1
119
770
R01AD12
ATC
fluticasone furoate; nasal
1.8
6.1
128
847
M17.9
ICD-10 Finland
Gonarthrosis, unspecified
2.1
6.1
66
352
M01AB08
ATC
etodolac; oral
2.6
6.1
35
142
R01AD58
ATC
fluticasone, combinations; nasal
1.8
6.0
103
640
N06CA01
ATC
amitriptyline and psycholeptics; systemic
2.3
6.0
49
233
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
109
612
2.09
9.00
1.4
1.3
12.21
14.97
u/ml
0.13
45
252
216
1571
1.85
8.03
2.4
2.0
97.30
98.56
pmol/l
0.15
125
772
211
1547
1.81
7.42
3.3
2.6
—
—
estimate
—
0
0
255
1999
1.82
6.97
4.6
4.5
6.97
6.55
mmol/l
1.22
244
1895
150
1035
1.74
6.18
1.8
1.7
20.83
20.80
nmol/l
0.01
137
875
105
654
1.83
6.12
5.1
3.8
176.66
270.78
ng/l
0.32
80
507
108
686
1.80
5.88
1.4
1.3
18.44
32.11
iu/ml
0.97
30
225
119
781
1.76
5.78
6.0
4.2
1.02
1.02
kg/l
0.55
92
512
211
1633
1.65
5.42
2.7
2.5
74.10
79.19
nmol/l
2.08
196
1466
94
596
1.76
5.07
3.2
2.7
0.59
0.94
e6/l
1.52
58
281
233
1880
1.61
4.81
5.1
3.9
0.00
8.71
estimate
0.80
35
402
62
351
1.91
4.80
2.6
2.3
29.45
34.70
u/l
0.56
51
288
220
1754
1.59
4.75
6.7
6.6
1.22
1.22
mmol/l
0.75
205
1511
231
1866
1.59
4.69
4.6
3.9
0.00
0.00
estimate
-0.00
33
395
363
3335
2.55
4.63
20.4
14.9
20.33
23.20
mg/l
1.12
324
2704
116
802
1.64
4.49
1.7
1.6
1.50
1.12
mg/l
0.31
93
633
145
1065
1.58
4.35
1.9
2.1
152.92
161.35
u/l
0.14
137
1008
123
869
1.61
4.34
2.9
2.1
2.95
2.92
mg/l
0.04
114
743
233
1909
1.56
4.27
5.1
3.9
0.00
0.80
estimate
0.52
31
387
228
1869
1.54
4.09
6.2
6.3
10.52
11.09
umol/l
0.42
222
1784
312
2752
1.71
4.09
5.3
4.6
14.66
14.82
pmol/l
0.64
304
2530
198
1586
1.51
3.88
5.8
5.7
1.22
1.22
mmol/l
0.41
191
1461
203
1636
1.51
3.85
3.8
2.9
117.26
106.67
ug/l
0.27
198
1520
197
1580
1.51
3.82
21.6
13.8
1.30
1.23
inr
0.98
169
1297
115
824
1.56
3.75
1.3
1.3
0.78
1.79
u/ml
1.09
38
235
62
385
1.73
3.55
2.2
2.6
6.59
7.45
umol/l
0.20
55
342
368
3455
2.47
3.50
23.2
17.5
3.98
3.95
mmol/l
1.26
363
3379
117
855
1.53
3.46
2.2
2.6
333.25
332.44
umol/l
0.03
106
754
82
553
1.61
3.43
3.3
2.8
4.40
2.77
e6/l
0.34
46
238
190
1541
1.46
3.32
4.8
4.5
36.40
35.91
g/l
0.74
184
1450
142
1093
1.47
3.23
3.1
2.3
51.59
70.23
u/l
2.19
135
1006
236
2008
1.45
3.13
9.0
9.7
4.04
4.05
e9/l
0.01
216
1737
135
1042
1.46
2.99
2.8
3.1
1448.28
1062.47
ng/l
0.37
121
895
70
470
1.60
2.97
5.8
6.2
103.83
103.95
mmol/l
0.08
70
470
163
1308
1.43
2.91
3.9
3.6
62.23
77.43
ng/l
0.11
106
931
313
2835
1.56
2.89
25.2
19.0
13.75
13.64
%
0.73
313
2803
55
355
1.64
2.73
5.8
7.5
0.63
1.05
mmol/l
0.43
45
302
36
208
1.81
2.65
7.3
9.2
94.30
93.70
%
0.36
36
208
61
410
1.58
2.58
1.9
1.8
—
—
—
0
0
5
8
6.31
2.38
1.6
1.3
—
—
—
0
0
20
98
2.10
2.36
1.4
1.2
—
—
—
0
0
22
112
2.02
2.35
1.8
1.7
—
—
—
0
0
26
142
1.89
2.29
2.9
4.0
1.47
1.43
%
0.12
26
135
144
1172
1.37
2.23
3.3
3.0
28.33
30.74
u/l
0.72
138
1106
351
3311
1.68
2.22
6.0
5.1
6.10
5.89
mmol/l
2.75
339
3059
10
35
2.91
2.22
1.6
1.5
—
—
—
0
0
23
122
1.94
2.21
1.3
1.1
—
—
—
0
0
23
122
1.94
2.21
1.2
1.1
—
—
—
0
0
61
426
1.51
2.18
1.9
1.8
—
—
—
0
0
108
845
1.39
2.12
2.7
2.1
—
—
—
0
0
10
38
2.67
2.02
1.2
1.0
—
—
—
0
0
18
91
2.03
1.98
1.2
1.2
—
—
—
0
0
6
16
3.79
1.94
1.2
1.4
—
—
—
0
0
139
1148
1.33
1.90
3.0
3.1
7.29
7.01
mmol/l
0.30
123
980
166
1410
1.31
1.85
4.3
3.8
0.00
0.03
estimate
1.41
22
325
9
36
2.54
1.75
1.1
1.1
—
—
—
0
0
340
3220
1.48
1.69
7.6
6.2
39.79
39.00
mmol/mol
1.08
333
3027
119
979
1.31
1.64
3.6
3.0
0.48
0.48
e6/l
0.00
92
690
74
567
1.38
1.64
2.3
1.9
—
—
—
0
0
354
3388
1.56
1.58
5.8
5.2
4.76
4.75
mmol/l
0.05
345
3167
12
57
2.14
1.56
1.4
1.1
1.60
10.06
u/ml
—
5
18
358
3436
1.60
1.56
6.7
5.9
2.78
2.77
mmol/l
0.10
348
3208
74
572
1.36
1.55
2.0
1.7
1110.60
1279.51
nmol/l
1.09
62
416
97
782
1.32
1.54
2.3
2.7
2.45
2.46
mmol/l
0.29
86
707
16
86
1.90
1.52
1.6
1.4
—
—
—
0
0
16
86
1.90
1.52
2.0
3.2
0.00
2.54
index
—
7
50
133
1121
1.28
1.52
3.7
3.8
9.01
7.19
mg/mmol
0.22
79
682
6
21
2.89
1.51
3.2
1.4
29.83
39.40
mg/l
—
6
15
9
38
2.40
1.46
1.1
1.1
—
—
—
0
0
7
28
2.53
1.46
1.0
1.0
—
—
—
0
0
227
2051
1.26
1.43
3.0
2.9
—
—
—
0
0
9
40
2.28
1.41
1.4
1.1
—
—
—
0
0
11
53
2.11
1.40
1.1
1.3
—
—
—
0
0
5
17
2.97
1.36
1.2
1.2
0.60
1.20
promille
—
5
11
26
170
1.57
1.30
1.4
1.3
—
—
—
0
0
345
3307
1.42
1.28
18.1
14.6
81.07
79.98
ml/min/173m2
0.50
321
3062
73
581
1.32
1.27
1.4
1.5
—
—
—
0
0
18
108
1.70
1.24
1.6
1.5
1.18
1.18
g/l
0.00
18
103
34
239
1.46
1.23
2.2
1.6
—
—
—
0
0
13
71
1.86
1.21
1.5
1.4
—
—
—
0
0
13
71
1.86
1.21
1.5
1.4
—
—
—
0
0
16
94
1.73
1.19
1.5
1.5
204.81
294.66
mu/l
2.43
16
88
31
216
1.47
1.18
1.9
1.6
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
15
88
1.73
1.13
3.7
2.7
0.44
0.37
iu/ml
—
10
51
22
144
1.56
1.11
1.7
1.8
1.84
5.39
iu/ml
—
5
37
5
22
2.29
1.03
1.4
1.0
—
—
—
0
0
52
407
1.32
1.03
3.8
4.2
12.93
26.44
ug/l
0.31
43
332
7
34
2.08
1.03
1.1
1.1
—
—
—
0
0
349
3374
1.37
1.00
5.5
5.1
1.45
1.53
mmol/l
3.33
339
3137
35
260
1.38
0.97
1.5
1.4
—
—
—
0
0
15
93
1.64
0.95
2.3
2.5
—
—
—
0
0
15
93
1.64
0.95
2.1
4.5
2.64
2.65
ratio
—
10
50
17
109
1.59
0.95
2.0
1.4
232.64
300.03
ug/g
0.61
11
57
8
44
1.84
0.86
1.1
1.7
—
—
—
0
0
0
25
0.00
0.79
0.0
1.9
—
0.31
—
0
13
6
34
1.78
0.76
1.0
1.1
1.49
1.42
g/l
—
6
29
11
67
1.66
0.76
1.1
1.6
—
—
—
0
0
165
1510
1.16
0.74
2.1
1.9
1.59
1.34
mmol/l
2.70
150
1271
15
100
1.52
0.74
1.7
1.6
—
—
—
0
0
9
57
1.59
0.71
1.2
1.3
—
—
—
0
0
14
93
1.52
0.70
1.9
2.4
10.59
11.94
mg/l
0.60
14
87
78
675
1.20
0.69
1.4
1.5
—
—
—
0
0
33
414
0.78
0.67
5.0
4.7
28.58
32.58
%
1.66
26
259
143
1304
1.15
0.66
2.8
3.4
2.36
2.36
mmol/l
0.36
135
1191
333
3237
1.21
0.62
4.7
4.3
1.45
1.27
mmol/l
4.55
323
2985
20
265
0.74
0.60
1.7
1.9
3.55
3.54
mmol/l
0.01
11
205
0
22
0.00
0.59
0.0
2.4
—
—
—
0
0
12
81
1.50
0.57
1.2
1.1
4.03
3.79
mmol/l
0.26
12
74
8
54
1.49
0.57
1.0
1.1
—
—
—
0
0
25
194
1.31
0.57
1.3
1.3
—
—
—
0
0
30
239
1.28
0.57
1.2
1.2
105.79
150.32
u/ml
—
10
114
45
377
1.22
0.56
10.7
6.2
—
—
—
0
0
8
55
1.46
0.56
1.1
1.6
—
—
—
0
0
10
65
1.55
0.56
1.4
1.4
—
—
—
0
0
243
2316
1.13
0.55
3.1
3.1
48.37
45.36
u/l
0.19
231
2184
12
84
1.44
0.50
2.2
1.2
—
—
—
0
0
21
267
0.77
0.49
2.6
1.8
—
—
—
0
0
35
291
1.22
0.48
1.7
2.8
69.76
62.97
ml/min/173m2
0.69
17
119
30
363
0.81
0.47
1.6
2.1
3.66
3.39
ratio
0.49
22
299
80
722
1.14
0.43
1.9
1.7
393.15
12228254.08
pmol/l
0.50
74
597
6
91
0.65
0.43
1.0
1.3
—
—
—
0
0
8
57
1.41
0.42
1.1
1.5
—
—
—
0
0
39
334
1.19
0.41
3.7
3.1
2.65
1.98
mmol/l
0.38
32
296
11
79
1.40
0.41
3.2
1.7
—
—
—
0
0
11
79
1.40
0.41
3.4
1.8
—
—
—
0
0
5
34
1.48
0.40
1.0
1.1
—
—
—
0
0
0
18
0.00
0.40
0.0
1.9
—
—
—
0
0
0
18
0.00
0.40
0.0
1.9
—
—
—
0
0
5
37
1.36
0.37
1.0
1.7
—
—
—
0
0
111
1032
1.11
0.37
3.8
3.3
0.00
0.08
estimate
0.52
23
308
6
46
1.31
0.33
5.0
2.0
—
—
—
0
0
11
84
1.32
0.30
1.5
1.2
—
—
—
0
0
25
289
0.86
0.27
2.4
1.9
—
—
—
0
0
19
159
1.21
0.27
3.8
3.2
58.49
1467.49
u/ml
0.94
13
137
110
1041
1.08
0.25
4.9
3.9
0.00
0.01
estimate
0.50
32
371
5
38
1.32
0.23
1.0
1.6
—
—
—
0
0
5
40
1.25
0.22
1.0
1.1
113.40
109.10
pmol/l
—
5
40
5
42
1.19
0.21
3.0
4.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
5
43
1.16
0.21
1.0
1.2
6.74
7.70
mmol/l
—
5
34
22
193
1.15
0.20
1.0
1.0
—
—
—
0
0
12
99
1.22
0.20
2.8
1.2
—
—
—
0
0
24
214
1.13
0.18
3.2
2.5
125.67
129.09
g/l
0.40
24
209
7
60
1.17
0.18
1.3
1.3
—
—
—
0
0
5
67
0.74
0.17
3.4
2.5
14.00
16.01
%
—
5
67
7
90
0.77
0.14
1.6
1.2
—
—
—
0
0
11
128
0.86
0.13
1.0
1.2
1.43
1.59
g/l
1.09
11
128
9
110
0.81
0.13
1.6
1.2
—
30.62
—
0
6
31
287
1.09
0.13
2.5
3.8
1.24
1.23
mmol/l
0.30
31
245
17
152
1.12
0.12
1.4
1.5
—
—
—
0
0
21
191
1.11
0.12
2.5
2.1
0.46
0.61
%
1.55
21
191
10
115
0.87
0.11
4.6
1.9
—
—
—
0
0
5
46
1.09
0.09
2.0
1.5
—
—
—
0
0
12
107
1.13
0.08
2.0
1.7
5.02
3.96
iu/l
—
5
41
12
133
0.90
0.08
1.0
1.2
1.05
0.92
g/l
0.70
12
133
9
84
1.07
0.07
1.4
1.8
—
—
—
0
0
13
118
1.11
0.07
1.7
1.8
—
—
—
0
0
30
286
1.05
0.06
5.5
6.1
9.28
9.19
mmol/l
0.03
30
271
61
593
1.03
0.06
5.3
5.0
1.55
2.50
ug/l
1.04
56
541
10
110
0.91
0.05
2.1
1.7
—
—
—
0
0
13
121
1.08
0.03
1.4
1.4
0.09
0.24
mg/l
—
5
53
49
479
1.03
0.03
4.6
4.4
23.27
21.87
%
0.27
20
231
13
123
1.06
0.01
1.5
1.4
—
—
—
0
0
35
344
1.02
0.00
3.8
3.3
—
—
—
0
0
36
365
0.98
0.00
2.9
2.9
0.69
0.76
ug/l
0.24
24
232
11
106
1.04
0.00
2.2
2.7
23.83
25.56
mmol/l
0.74
11
106
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.2
—
1.20
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.6
—
4.80
—
0
9
7
71
0.99
-0.00
1.1
1.4
—
—
—
0
0
(3002348) Coagulation factor XII activity actual/normal in Platelet poor plasma by Coagulation assay
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.6
—
7.36
—
0
8
0
6
0.00
-0.00
0.0
1.0
—
106.50
—
0
6
0
8
0.00
-0.00
0.0
2.6
—
—
—
0
0
14
140
1.00
-0.00
1.9
1.9
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.6
—
9.96
—
0
9
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint G6_TARSTUN and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_TARSTUN | 0.804 [0.66, 0.97] | 0.026 |
| Birth year | 0.994 [0.99, 1.0] | 0.166 |
During the follow-up period (1.1.1998 — 31.12.2019), 109 out of 1139 females with G6_TARSTUN died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_TARSTUN | 0.961 [0.76, 1.22] | 0.747 |
| Birth year | 0.989 [0.98, 1.0] | 0.019 |
During the follow-up period (1.1.1998 — 31.12.2019), 82 out of 501 males with G6_TARSTUN died.
Mortality risk
Mortality risk for people of age
years, who have G6_TARSTUN.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.078% | 0.209% |
| 5 | 0.458% | 1.193% |
| 10 | 1.154% | 2.996% |
| 15 | 2.191% | 5.581% |
| 20 | 4.018% | 9.683% |
Relationships between endpoints
↥Index endpoint: G6_TARSTUN – Tarsal tunnel syndrome
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data