peripheral nervous system disease: A disease involving the peripheral nervous system.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
132 |
4. Check minimum number of eventsNone |
132 |
5. Include endpointsNone |
132 |
6. Filter based on genotype QC (FinnGen only) |
119 |
Control definitions (FinnGen only)
- Control exclude
- G6_NERPLEX
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- G54
- Name in latin
- Morbositates plexus lumbosacralis
Similar endpoints
↥List of similar endpoints to
Lumbosacral plexus disorders
based on the number of shared cases.
Similar with more cases:
- Nerve, nerve root and plexus disorders
- Neurological diseases
- Neurological diseases, wide definition
- Any operation in hilmo
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 903 | 486 | 412 |
| Only index persons | 807 | 435 | 372 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.02 | 0.02 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 56.12 | 55.89 | 56.21 |
| Only index persons | 54.07 | 54.21 | 53.92 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 119 | 71 | 48 |
| Unadjusted period prevalence (%) | 0.02 | 0.03 | 0.02 |
| Median age at first event (years) | 54.99 | 52.75 | 58.31 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 121
- Matched controls
- 1210
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G54.1
ICD-10 Finland
Lumbosacral plexus disorders
+∞
159.0
115
*
N03AX16
ATC
[U] pregabalin
11.7
43.0
73
139
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
8.3
27.1
47
86
M54.4
ICD-10 Finland
Lumbago with sciatica
7.5
26.2
53
114
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
9.7
24.7
34
47
M48.0
ICD-10 Finland
Spinal stenosis
8.2
24.1
40
69
N03AX12
ATC
[U] gabapentin; oral
6.9
23.4
50
112
N06AA09
ATC
amitriptyline; systemic
7.4
18.2
31
54
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
6.4
18.0
37
78
ACC51
NOMESCO Finland
Release of median nerve
+∞
17.1
16
*
N02AX02
ATC
tramadol; systemic, rectal
5.1
17.0
82
351
XA402
NOMESCO Finland
ENMG
39.4
16.3
20
6
G56.0
ICD-10 Finland
Carpal tunnel syndrome
16.2
15.6
25
19
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
6.6
14.2
26
48
M54.9
ICD-10 Finland
Dorsalgia, unspecified
5.6
13.8
31
70
M54.1
ICD-10 Finland
Radiculopathy
15.6
13.0
21
16
N06AX21
ATC
duloxetine; oral
5.3
12.9
31
74
N02AA05
ATC
oxycodone; systemic
4.3
12.5
43
137
G54.0
ICD-10 Finland
Brachial plexus disorders
72.1
11.9
13
*
ABC36
NOMESCO Finland
Decompression of lumbar nerve roots
11.2
10.8
20
21
ACC59
NOMESCO Finland
Decompression and freeing of adhesions of peripheral nerve: other or unspecified
120.0
10.6
11
*
N02BF02
ATC
pregabalin; oral
5.6
9.7
20
41
M54.5
ICD-10 Finland
Low back pain
3.3
9.5
60
278
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
9.6
9.5
19
23
SPAT1153
SPAT
Removal of sutures
3.3
9.1
54
240
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
5.2
9.0
20
44
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
3.9
8.9
32
103
M79.6
ICD-10 Finland
Pain in limb
3.2
8.9
72
383
L28
ICPC
Limited function/disability (L)
3.5
8.5
38
141
N06AX16
ATC
venlafaxine; oral
3.7
7.7
29
96
L03
ICPC
Low back symptom/complaint
3.0
7.6
48
217
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
4.6
7.4
19
47
WX308
NOMESCO Finland
Sacral anesthesy
42.5
6.8
8
*
Z01.8
ICD-10 Finland
Other specified special examinations
3.0
6.8
37
153
AA1AD
NOMESCO Finland
CT of head and brain
2.8
6.8
47
222
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
2.9
6.8
44
201
N03AE01
ATC
clonazepam; systemic
6.9
6.7
16
26
M50.1
ICD-10 Finland
Cervical disc disorder with radiculopathy
9.0
6.5
13
16
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.7
6.5
57
303
3531A
ICD-9 Finland
Nerve root and plexus disorders, Lumbosacral plexus lesions
+∞
6.3
6
*
A02BC02
ATC
pantoprazole; systemic
3.0
6.3
94
647
N03AX09
ATC
lamotrigine; oral
7.4
6.2
14
21
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.7
6.2
45
216
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
10.9
6.2
11
11
M01AH01
ATC
celecoxib; oral
3.1
6.2
31
122
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
6.0
6.1
16
30
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.6
6.1
66
385
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
3.1
6.0
30
117
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
84
518
3.03
7.45
6.2
6.3
1.22
1.21
mmol/l
0.15
72
444
31
114
3.31
6.94
4.7
7.8
1.24
1.00
mmol/l
0.12
24
92
77
470
2.76
6.67
3.3
2.6
—
—
estimate
—
0
0
89
602
2.81
6.02
9.6
9.9
4.04
4.00
e9/l
0.08
83
528
68
410
2.50
5.75
5.4
3.6
43.77
32.82
ng/l
0.24
53
280
74
478
2.41
5.19
6.6
5.6
1.22
1.22
mmol/l
0.26
68
440
45
238
2.42
4.91
3.1
2.2
—
—
—
0
0
56
331
2.29
4.70
3.4
2.5
47.57
67.95
u/l
0.92
56
311
35
169
2.51
4.62
1.9
2.2
12.19
14.22
umol/l
0.79
35
157
30
138
2.56
4.36
5.8
7.3
103.87
104.02
mmol/l
0.04
30
138
23
93
2.82
4.27
3.5
3.4
—
—
—
0
0
58
365
2.13
4.02
3.1
3.3
29.31
29.42
u/l
0.02
52
346
100
788
2.55
3.84
3.9
4.3
15.14
14.80
pmol/l
0.77
92
710
44
253
2.16
3.80
2.9
2.1
2.87
2.98
mg/l
0.14
38
221
35
186
2.24
3.65
1.7
1.3
1.95
6.77
u/ml
1.15
12
70
31
161
2.24
3.40
1.9
2.2
2.41
2.36
g/l
0.23
31
146
68
475
1.99
3.36
2.8
2.5
76.64
77.79
nmol/l
0.11
62
430
115
1017
3.64
3.33
26.5
14.8
21.93
23.88
mg/l
0.29
106
832
15
55
2.97
3.29
3.5
3.1
3.58
1.37
mmol/l
—
9
42
37
209
2.11
3.29
1.6
1.3
12.80
28.06
iu/ml
—
10
63
56
384
1.85
2.77
6.1
3.3
—
—
—
0
0
19
88
2.38
2.68
4.4
7.1
1.39
1.35
mmol/l
0.07
19
88
24
125
2.15
2.58
2.2
1.7
—
—
—
0
0
6
11
5.67
2.57
2.8
2.1
3.28
2.02
mmol/l
—
6
11
109
945
2.55
2.54
5.3
5.2
1.89
1.92
mu/l
0.11
101
862
29
169
1.94
2.31
2.6
1.8
—
—
—
0
0
7
18
4.06
2.29
1.1
1.2
—
—
—
0
0
62
458
1.73
2.27
2.5
2.1
93.96
95.74
pmol/l
0.14
42
242
47
326
1.72
2.12
2.9
3.1
1022.48
1259.90
ng/l
0.29
41
264
7
21
3.47
1.99
2.7
1.3
—
—
—
0
0
114
1048
2.52
1.84
28.6
17.4
3.99
3.96
mmol/l
0.45
114
1028
114
1047
2.53
1.84
28.6
17.3
139.27
139.86
mmol/l
1.70
114
1031
8
29
2.88
1.82
1.1
1.1
0.00
0.00
g/l
—
8
29
43
306
1.63
1.71
5.7
3.2
0.41
0.55
e6/l
0.27
36
226
21
122
1.87
1.68
2.0
1.7
—
—
—
0
0
57
437
1.58
1.65
4.9
3.7
0.00
0.03
estimate
0.50
15
98
72
584
1.58
1.63
5.3
3.8
0.00
0.00
estimate
-0.00
15
108
12
57
2.23
1.61
3.8
2.6
32.69
41.80
u/l
1.23
12
47
13
64
2.16
1.61
1.9
1.6
—
—
—
0
0
71
575
1.57
1.61
5.3
3.7
0.00
0.00
estimate
-0.00
17
118
71
580
1.54
1.51
5.3
3.7
0.00
0.00
estimate
-0.00
17
122
44
328
1.54
1.40
4.6
3.9
0.00
0.02
estimate
0.50
16
110
17
98
1.85
1.40
2.7
2.3
344.53
374.04
nmol/l
0.30
17
91
30
205
1.62
1.38
4.5
3.7
2449.60
327.33
ng/l
0.41
20
159
5
17
3.02
1.37
5.2
1.9
6.60
10.29
mmol/l
—
5
17
5
17
3.02
1.37
2.0
1.2
15549.60
7422.90
e6/l
—
5
10
27
181
1.63
1.34
7.0
2.9
0.83
1.07
e6/l
0.29
18
102
115
1083
2.25
1.25
32.4
19.5
76.18
76.34
umol/l
0.02
115
1074
5
19
2.70
1.23
1.8
1.8
—
—
—
0
0
17
104
1.74
1.17
3.0
2.5
27.42
33.46
u/l
0.77
12
85
34
250
1.50
1.13
4.8
3.9
1.02
1.02
kg/l
0.01
28
173
9
46
2.03
1.06
2.2
1.2
—
—
—
0
0
7
34
2.12
1.04
2.6
2.0
—
—
—
0
0
11
62
1.85
0.98
1.1
1.2
432.27
158.80
u/ml
0.39
11
57
24
169
1.52
0.97
1.8
1.6
1190.61
1172.65
nmol/l
0.03
18
131
6
27
2.28
0.95
1.2
1.3
—
—
—
0
0
115
1099
1.94
0.88
37.7
22.9
91.44
91.34
fl
0.09
115
1090
115
1099
1.94
0.88
38.0
23.1
129.73
135.13
g/l
3.39
115
1090
115
1099
1.94
0.88
37.8
23.0
4.34
4.48
e12/l
2.06
115
1077
115
1099
1.94
0.88
37.9
23.0
249.72
247.50
e9/l
0.15
115
1082
115
1099
1.94
0.88
38.1
23.4
39.34
40.39
%
1.82
115
1090
106
991
1.56
0.83
5.5
5.2
5.81
5.94
mmol/l
0.64
97
919
23
167
1.47
0.81
7.9
3.3
3.59
2.35
e6/l
0.21
14
89
104
972
1.50
0.77
7.1
6.2
39.95
39.19
mmol/mol
0.41
93
909
7
38
1.89
0.75
3.1
2.2
—
—
—
0
0
7
39
1.84
0.74
3.7
2.2
—
—
—
0
0
43
357
1.32
0.69
4.7
3.6
15.18
8.55
mg/mmol
0.38
26
216
38
316
1.30
0.60
4.2
3.2
0.00
0.00
estimate
-0.00
15
89
6
35
1.75
0.58
2.3
1.8
—
—
—
0
0
9
59
1.57
0.56
3.9
2.6
1.29
1.27
%
—
9
59
5
33
1.54
0.42
1.6
1.5
—
—
—
0
0
5
35
1.45
0.40
1.0
1.3
—
—
—
0
0
5
35
1.45
0.40
1.0
1.3
—
—
—
0
0
8
112
0.69
0.39
3.3
7.4
—
—
—
0
0
29
246
1.24
0.39
1.6
1.3
1.12
2.91
u/ml
0.91
12
64
5
36
1.41
0.38
1.2
2.1
—
—
—
0
0
29
247
1.23
0.37
5.3
4.7
20.79
21.49
%
0.09
14
131
6
42
1.45
0.36
1.2
1.9
—
—
—
0
0
101
969
1.26
0.36
4.9
4.2
1.34
1.28
mmol/l
0.36
94
890
6
46
1.32
0.33
1.2
1.9
—
—
—
0
0
41
455
0.85
0.32
2.0
2.0
1.27
1.35
mmol/l
0.32
32
374
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.9
—
—
—
0
0
0
11
0.00
0.21
0.0
1.7
—
—
—
0
0
0
11
0.00
0.21
0.0
1.9
—
—
—
0
0
0
11
0.00
0.21
0.0
1.9
—
—
—
0
0
0
11
0.00
0.21
0.0
1.7
—
—
—
0
0
0
11
0.00
0.21
0.0
1.7
—
—
—
0
0
0
11
0.00
0.21
0.0
1.9
—
—
—
0
0
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
0
12
0.00
0.21
0.0
1.8
—
—
—
0
0
0
12
0.00
0.21
0.0
1.8
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
1.33
—
0
7
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.6
—
39.85
—
0
14
15
173
0.85
0.18
1.6
1.5
—
—
—
0
0
15
171
0.86
0.16
1.3
1.5
—
—
—
0
0
12
106
1.15
0.10
1.2
1.6
1.49
1.51
%
0.01
12
90
20
185
1.10
0.09
3.9
3.2
0.69
0.75
ug/l
0.18
15
132
5
60
0.83
0.08
1.0
1.4
—
—
—
0
0
7
63
1.12
0.08
2.1
4.0
4.18
4.32
pmol/l
—
7
58
9
84
1.08
0.07
1.1
1.6
—
—
—
0
0
10
91
1.11
0.04
1.4
1.4
—
—
—
0
0
104
1030
1.07
0.04
6.2
5.9
2.67
2.73
mmol/l
0.30
95
957
102
1011
1.06
0.03
5.5
5.0
1.48
1.48
mmol/l
0.02
94
937
101
1012
0.99
0.00
5.7
5.2
4.60
4.67
mmol/l
0.25
93
942
60
605
0.98
0.00
3.1
2.9
—
—
—
0
0
9
95
0.94
0.00
1.1
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
5
52
0.96
-0.00
1.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
7
78
0.89
-0.00
1.9
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
11.00
—
0
5
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
5
0.00
-0.00
0.0
1.0
—
132.80
—
0
5
0
6
0.00
-0.00
0.0
2.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
0
5
0.00
-0.00
0.0
3.2
—
95.20
—
0
5
0
6
0.00
-0.00
0.0
2.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
5.3
—
214.00
—
0
6
0
8
0.00
-0.00
0.0
1.0
—
1642.63
—
0
8
0
5
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
92.58
—
0
5
0
7
0.00
-0.00
0.0
1.4
—
101.43
—
0
7
0
5
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.7
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint G6_LSPLEX and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_LSPLEX | 1.681 [1.22, 2.31] | 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.403 |
During the follow-up period (1.1.1998 — 31.12.2019), 79 out of 391 females with G6_LSPLEX died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_LSPLEX | 1.151 [0.85, 1.56] | 0.365 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 70 out of 342 males with G6_LSPLEX died.
Mortality risk
Mortality risk for people of age
years, who have G6_LSPLEX.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.211% | 0.198% |
| 5 | 1.097% | 1.208% |
| 10 | 2.546% | 2.93% |
| 15 | 4.988% | 5.664% |
| 20 | 8.872% | 9.948% |
Relationships between endpoints
↥Index endpoint: G6_LSPLEX – Lumbosacral plexus disorders
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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