No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
103 |
4. Check minimum number of eventsNone |
103 |
5. Include endpointsNone |
103 |
6. Filter based on genotype QC (FinnGen only) |
97 |
Control definitions (FinnGen only)
- Control exclude
- G6_HYDROCEPH
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- G91
- Name in latin
- Hydrocephalia posttraumatica non specificata
Similar endpoints
↥List of similar endpoints to
Post-traumatic hydrocephalus, unspecified
based on the number of shared cases.
Similar with more cases:
- Hydrocephalus
- Other neurological diseases
- Neurological diseases
- Neurological diseases, wide definition
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 825 | 244 | 570 |
| Only index persons | 682 | 217 | 465 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.02 |
| Only index persons | 0.01 | 0.01 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 60.74 | 61.47 | 60.20 |
| Only index persons | 60.24 | 61.26 | 59.77 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 97 | 29 | 68 |
| Unadjusted period prevalence (%) | 0.02 | 0.01 | 0.03 |
| Median age at first event (years) | 65.95 | 60.38 | 68.32 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 99
- Matched controls
- 990
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G91.3
ICD-10 Finland
Post-traumatic hydrocephalus, unspecified
+∞
142.7
99
*
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
+∞
70.4
59
*
G91.2
ICD-10 Finland
Normal-pressure hydrocephalus
+∞
33.2
30
*
G91.0
ICD-10 Finland
Communicating hydrocephalus
+∞
29.7
27
*
AAF20
NOMESCO Finland
Revision of shunt of ventricle of brain
347.7
27.1
26
*
S06.5
ICD-10 Finland
Traumatic subdural haemorrhage
27.7
25.4
35
19
AA1AD
NOMESCO Finland
CT of head and brain
8.5
24.7
68
204
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
28.4
24.2
33
17
T90.5
ICD-10 Finland
Sequelae of intracranial injury
86.9
24.2
26
*
AAF00
NOMESCO Finland
Ventriculostomy
+∞
21.6
20
*
AA7AA
NOMESCO Finland
Liquor cerebri shunt X-ray examinatin without contrast
+∞
20.5
19
*
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
6.6
19.4
65
222
G91.9
ICD-10 Finland
Hydrocephalus, unspecified
+∞
19.4
18
*
ZXD05
NOMESCO Finland
Urgent procedure
5.9
17.3
60
206
S06.3
ICD-10 Finland
Focal brain injury
72.4
16.4
18
*
S06.2
ICD-10 Finland
Diffuse brain injury
174.7
14.9
15
*
AAF15
NOMESCO Finland
Ventriculoatrial shunt
+∞
13.9
13
*
AAF25
NOMESCO Finland
Removal of shunt of ventricle of brain
+∞
13.9
13
*
AA1AA
NOMESCO Finland
Head X-ray examination
47.0
13.6
16
*
W19
ICD-10 Finland
Unspecified fall
6.1
12.5
26
55
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
6.6
11.4
21
39
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
5.9
11.1
23
48
ZXE10
NOMESCO Finland
More than one and less than three hours
4.0
10.7
54
228
AAD10
NOMESCO Finland
Evacuation of chronic subdural haematoma
26.8
10.6
14
6
N06AB04
ATC
citalopram; systemic
4.4
10.4
35
110
K90
ICPC
Stroke/cerebrovascular accident
17.1
10.4
16
11
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
6.2
10.3
20
39
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
4.3
10.3
35
111
L28
ICPC
Limited function/disability (L)
4.2
10.2
37
123
S06.6
ICD-10 Finland
Traumatic subarachnoid haemorrhage
29.5
10.1
13
5
T85.0
ICD-10 Finland
Mechanical complication of ventricular intracranial (communicating) shunt
+∞
9.5
9
*
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
4.4
9.0
28
82
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.7
8.9
40
153
G91.1
ICD-10 Finland
Obstructive hydrocephalus
+∞
8.4
8
*
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
7.8
8.4
19
29
S06.0
ICD-10 Finland
Concussion
4.7
8.2
22
57
N03AX14
ATC
levetiracetam; systemic
9.8
8.2
16
19
I69.1
ICD-10 Finland
Sequelae of intracerebral haemorrhage
16.8
7.9
12
8
WX730
NOMESCO Finland
Conventional respirator
+∞
7.4
7
*
N99
ICPC
Neurological disease other
32.6
7.3
9
*
X59
ICD-10 Finland
Exposure to unspecified factor
3.6
7.1
30
108
AAD05
NOMESCO Finland
Evacuation of acute subdural haematoma
43.1
6.9
8
*
SPAT1216
SPAT
Assessment of functional ability
3.6
6.7
27
94
N05BA01
ATC
diazepam; systemic, rectal
4.0
6.6
21
62
AAF99
NOMESCO Finland
Other shunt operation on ventricle of brain or intracerebral cyst
74.4
6.5
7
*
M03BX01
ATC
baclofen; systemic
74.4
6.5
7
*
N18
ICPC
Paralysis/weakness
12.2
6.5
11
10
N06AX16
ATC
venlafaxine; oral
4.1
6.4
20
58
N39.4
ICD-10 Finland
Other specified urinary incontinence
6.0
6.4
17
33
TAA40
NOMESCO Finland
Cathetrisation of cerebrospinal fluid through skin
+∞
6.3
6
*
WX408
NOMESCO Finland
General anesthesy, balanced
3.1
6.3
37
162
N06AX11
ATC
mirtazapine; oral
2.9
6.0
42
201
Z2445
NOMESCO Finland
Psychologist
8.9
6.0
12
15
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
24
7
44.51
20.00
1.8
1.4
—
—
—
0
0
24
22
14.00
13.98
2.1
1.3
162.44
295.50
e6/l
0.18
18
16
23
22
13.24
13.12
2.1
1.1
3.27
10.33
e6/l
0.46
15
15
10
23
4.71
3.41
2.1
1.3
—
—
—
0
0
7
11
6.75
3.24
4.1
4.0
347.14
324.64
umol/l
—
7
11
26
140
2.16
2.64
7.6
3.7
0.85
0.81
mmol/l
1.00
26
133
13
51
2.78
2.56
2.1
1.8
—
—
—
0
0
23
120
2.19
2.52
10.8
6.3
0.97
1.06
mmol/l
0.75
23
110
26
143
2.11
2.50
2.3
2.0
—
—
—
0
0
51
356
1.89
2.49
16.6
6.8
1.21
1.20
mmol/l
0.30
46
325
21
106
2.25
2.48
2.4
2.0
—
—
—
0
0
9
28
3.43
2.37
1.3
1.2
—
—
—
0
0
20
112
1.98
1.81
2.4
1.9
—
—
—
0
0
54
414
1.67
1.71
16.5
7.7
1.21
1.20
mmol/l
0.27
48
361
62
726
0.61
1.50
5.0
5.2
1.31
1.40
mmol/l
1.00
57
669
22
137
1.78
1.45
5.3
2.8
0.56
1.02
e6/l
0.69
15
79
0
37
0.00
1.37
0.0
1.7
—
3.48
—
0
29
15
242
0.55
1.29
2.7
3.3
0.61
0.74
ug/l
—
10
156
26
181
1.59
1.14
4.0
2.4
—
—
—
0
0
24
332
0.63
1.11
3.6
4.7
20.47
21.67
%
0.15
11
156
41
321
1.47
1.05
4.6
3.2
—
—
—
0
0
5
22
2.34
1.04
1.4
1.0
—
—
—
0
0
14
84
1.78
1.04
10.9
9.5
—
—
—
0
0
62
704
0.68
1.00
4.9
4.4
1.36
1.25
mmol/l
0.74
57
646
0
29
0.00
0.99
0.0
1.5
—
—
—
0
0
20
135
1.60
0.99
5.6
3.0
0.27
1.89
e6/l
1.64
15
76
14
87
1.71
0.93
4.4
3.9
—
—
—
0
0
15
97
1.64
0.87
5.6
4.1
5.83
5.71
kpa
0.19
15
91
65
725
0.70
0.87
5.1
5.5
5.76
6.05
mmol/l
1.63
59
668
0
24
0.00
0.80
0.0
1.7
—
0.01
—
0
5
0
26
0.00
0.79
0.0
1.2
—
—
—
0
0
0
26
0.00
0.79
0.0
1.2
—
—
—
0
0
16
110
1.54
0.74
32.6
7.6
14.71
11.72
kpa
1.19
16
105
16
110
1.54
0.74
32.7
7.6
4.78
5.18
kpa
0.60
16
104
23
294
0.72
0.66
2.2
2.0
1.53
1.25
mmol/l
0.59
17
239
23
178
1.38
0.60
5.4
3.6
1.02
1.02
kg/l
0.18
16
117
0
22
0.00
0.60
0.0
1.4
—
—
—
0
0
10
66
1.57
0.55
1.7
1.6
—
—
—
0
0
30
246
1.31
0.54
4.5
3.7
0.00
0.02
estimate
0.50
14
98
48
420
1.28
0.54
4.7
3.9
0.00
0.00
estimate
-0.00
14
111
41
352
1.28
0.53
3.8
4.2
54.21
62.88
ng/l
0.11
29
270
48
429
1.23
0.42
4.7
3.9
0.00
0.00
estimate
-0.00
13
99
0
15
0.00
0.41
0.0
1.4
—
196.66
—
0
7
41
361
1.23
0.41
2.3
2.2
96.00
93.10
pmol/l
0.20
25
187
0
18
0.00
0.40
0.0
1.3
—
—
—
0
0
42
469
0.82
0.39
17.3
9.2
4.66
4.27
e9/l
0.53
33
406
45
402
1.22
0.39
2.8
2.9
—
—
—
0
0
46
416
1.20
0.34
4.5
3.9
0.00
0.00
estimate
-0.00
15
107
55
584
0.87
0.24
3.5
4.5
12.88
12.57
mm/h
0.05
49
536
10
124
0.78
0.23
4.9
4.5
204.10
241.93
u/l
—
10
112
0
11
0.00
0.21
0.0
1.1
—
174.49
—
0
11
0
10
0.00
0.21
0.0
2.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
6
50
1.21
0.20
5.0
2.9
1.07
1.37
%
—
6
50
6
52
1.16
0.19
1.5
1.3
—
—
—
0
0
66
687
0.88
0.18
5.5
5.1
1.68
2.08
mu/l
2.72
58
619
35
323
1.13
0.18
4.0
3.9
0.00
0.03
estimate
0.49
11
88
23
255
0.87
0.18
2.9
3.7
0.00
0.00
estimate
-0.00
11
79
39
364
1.12
0.16
4.1
2.8
—
—
estimate
—
0
0
5
43
1.17
0.10
2.0
1.8
9.58
1.10
ug/l
—
5
36
61
628
0.93
0.09
36.0
21.9
13.98
13.81
%
0.41
61
623
29
273
1.09
0.09
4.0
4.2
17.72
11.24
mg/mmol
0.26
21
180
5
63
0.78
0.08
2.2
4.5
75.40
283.90
ng/l
—
5
55
9
100
0.89
0.06
1.6
1.5
—
—
—
0
0
31
298
1.06
0.05
2.4
3.4
1943.63
1730.78
ng/l
0.11
24
244
57
559
1.05
0.04
4.1
4.1
15.02
14.79
pmol/l
0.27
50
495
75
760
0.95
0.04
30.8
17.6
28.53
26.43
mg/l
0.18
63
640
25
260
0.95
0.04
5.0
3.2
25.92
29.49
u/l
1.08
25
245
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
2.3
—
1.29
—
0
7
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.9
—
61.17
—
0
7
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
4.0
—
158.81
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
7.8
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
33.84
—
0
5
0
5
0.00
-0.00
0.0
1.6
—
13.20
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
71.80
—
0
5
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint G6_HCPOSTRAU and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_HCPOSTRAU | 3.131 [2.25, 4.35] | < 0.001 |
| Birth year | 0.997 [0.99, 1.01] | 0.551 |
During the follow-up period (1.1.1998 — 31.12.2019), 72 out of 207 females with G6_HCPOSTRAU died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_HCPOSTRAU | 4.172 [3.17, 5.49] | < 0.001 |
| Birth year | 0.983 [0.97, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 235 out of 486 males with G6_HCPOSTRAU died.
Mortality risk
Mortality risk for people of age
years, who have G6_HCPOSTRAU.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.262% | 0.89% |
| 5 | 1.526% | 4.357% |
| 10 | 4.536% | 10.32% |
| 15 | 9.383% | 18.425% |
| 20 | 16.445% | 30.377% |
Relationships between endpoints
↥Index endpoint: G6_HCPOSTRAU – Post-traumatic hydrocephalus, unspecified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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