brain disease: A disease affecting the brain or part of the brain.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
229 |
4. Check minimum number of eventsNone |
229 |
5. Include endpointsNone |
229 |
6. Filter based on genotype QC (FinnGen only) |
213 |
Control definitions (FinnGen only)
- Control exclude
- G6_HYDROCEPH
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Hydrocephalus in other diseases
based on the number of shared cases.
Similar with more cases:
- Hydrocephalus
- Other neurological diseases
- Neurological diseases
- Neurological diseases, wide definition
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1769 | 924 | 839 |
| Only index persons | 1488 | 795 | 693 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.03 | 0.02 |
| Only index persons | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 56.83 | 58.92 | 54.41 |
| Only index persons | 57.38 | 58.88 | 55.66 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 213 | 137 | 76 |
| Unadjusted period prevalence (%) | 0.04 | 0.05 | 0.03 |
| Median age at first event (years) | 60.64 | 59.85 | 62.06 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 217
- Matched controls
- 2170
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
+∞
149.9
126
*
AAF00
NOMESCO Finland
Ventriculostomy
+∞
136.2
116
*
I60.9
ICD-10 Finland
Subarachnoid haemorrhage, unspecified
57.7
96.4
56
13
AA1AD
NOMESCO Finland
CT of head and brain
17.1
86.4
174
416
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
11.1
72.7
119
214
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
11.0
61.1
83
116
G94.2
ICD-10 Finland
Hydrocephalus in other diseases classified elsewhere
+∞
58.0
53
*
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
20.8
51.0
41
24
AAF20
NOMESCO Finland
Revision of shunt of ventricle of brain
+∞
49.9
46
*
N03AX14
ATC
levetiracetam; systemic
20.2
49.1
40
24
AA7AA
NOMESCO Finland
Liquor cerebri shunt X-ray examinatin without contrast
+∞
48.8
45
*
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
9.0
48.7
76
123
WX872
NOMESCO Finland
Intensive care
13.6
44.8
46
42
PA7AD
NOMESCO Finland
CT angiography of head and neck vasculature
15.1
44.0
42
34
I69.0
ICD-10 Finland
Sequelae of subarachnoid haemorrhage
99.2
43.9
47
6
AA5PD
NOMESCO Finland
CT examination of brain pefusion
162.5
39.2
40
*
PA2AD
NOMESCO Finland
CT angiography of brain
68.5
39.1
44
8
G91.9
ICD-10 Finland
Hydrocephalus, unspecified
+∞
35.4
33
*
AAF25
NOMESCO Finland
Removal of shunt of ventricle of brain
+∞
35.4
33
*
ZXD05
NOMESCO Finland
Urgent procedure
5.5
35.3
127
440
PA3AC
NOMESCO Finland
Carotis angiography with X-ray
107.4
33.9
36
*
PA2LT
NOMESCO Finland
Endovascular closure of extensive brain aneurysm
138.3
33.8
35
*
PA2BC
NOMESCO Finland
Cerebral extensive angiography with X-ray
52.5
33.1
39
9
I60.2
ICD-10 Finland
Subarachnoid haemorrhage from anterior communicating artery
103.8
32.8
35
*
G91.1
ICD-10 Finland
Obstructive hydrocephalus
+∞
32.1
30
*
WX730
NOMESCO Finland
Conventional respirator
69.1
31.2
35
6
WX404
NOMESCO Finland
Intravenous generell anesthesy
5.1
30.4
97
298
T85.0
ICD-10 Finland
Mechanical complication of ventricular intracranial (communicating) shunt
+∞
29.9
28
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
5.2
29.6
84
234
PA4AC
NOMESCO Finland
Vertebralis angiography with X-ray
+∞
28.8
27
*
G942, I602,
ICD-10 Finland
+∞
28.8
27
*
K90
ICPC
Stroke/cerebrovascular accident
27.5
25.8
35
15
TAA40
NOMESCO Finland
Cathetrisation of cerebrospinal fluid through skin
+∞
25.5
24
*
AAB10
NOMESCO Finland
Partial excision of intracranial lesion
34.5
23.5
30
10
G91.0
ICD-10 Finland
Communicating hydrocephalus
+∞
23.3
22
*
I61.5
ICD-10 Finland
Intracerebral haemorrhage, intraventricular
+∞
22.3
21
*
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
7.5
21.1
33
51
I60.1
ICD-10 Finland
Subarachnoid haemorrhage from middle cerebral artery
42.6
19.0
23
6
SPAT1215
SPAT
Assessment of need for medical rehabilitation
8.4
18.2
25
33
AAF50
NOMESCO Finland
Third ventriculostomy
+∞
18.0
17
*
G94.1
ICD-10 Finland
Hydrocephalus in neoplastic disease
+∞
16.9
16
*
I69.1
ICD-10 Finland
Sequelae of intracerebral haemorrhage
18.7
16.5
25
15
I61.0
ICD-10 Finland
Intracerebral haemorrhage in hemisphere, subcortical
20.6
16.4
24
13
G91.8
ICD-10 Finland
Other hydrocephalus
+∞
15.8
15
*
I60.0
ICD-10 Finland
Subarachnoid haemorrhage from carotid siphon and bifurcation
91.9
15.8
17
*
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
19.6
15.5
23
13
I67.1
ICD-10 Finland
Cerebral aneurysm, nonruptured
13.9
15.3
26
21
PA2KT
NOMESCO Finland
Endovascular closure of brain aneurysm
48.8
15.3
18
*
SPAT1229
SPAT
Assessment of need for aid
5.4
15.3
33
70
AA1AA
NOMESCO Finland
Head X-ray examination
27.3
15.0
20
8
PA2YT
NOMESCO Finland
Cerebral artery PTA with stent
86.1
14.8
16
*
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
11.7
14.7
27
26
XX3DW
NOMESCO Finland
Time consuming IT work
3.8
14.4
52
165
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
21.9
14.1
20
10
N18
ICPC
Paralysis/weakness
16.2
13.9
22
15
H02AB02
ATC
dexamethasone; systemic
3.7
13.7
53
176
G97.2
ICD-10 Finland
Intracranial hypotension following ventricular shunting
+∞
13.7
13
*
I60.7
ICD-10 Finland
Subarachnoid haemorrhage from intracranial artery, unspecified
+∞
13.7
13
*
R51.80
ICD-10 Finland
Headache
3.3
13.1
63
240
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
18.8
12.8
19
11
PA2MT
NOMESCO Finland
Endovascular closure of very extensive brain aneurysm
74.3
12.7
14
*
I60.6
ICD-10 Finland
Subarachnoid haemorrhage from other intracranial arteries
+∞
12.6
12
*
AAF99
NOMESCO Finland
Other shunt operation on ventricle of brain or intracerebral cyst
+∞
12.6
12
*
G942, I615,
ICD-10 Finland
+∞
12.6
12
*
WX882
NOMESCO Finland
High dependency care
9.8
12.1
24
27
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
12.1
11.8
21
19
AAC00
NOMESCO Finland
Ligature of intracranial aneurysm
20.3
11.8
17
9
WX408
NOMESCO Finland
General anesthesy, balanced
2.8
11.6
82
385
G91.2
ICD-10 Finland
Normal-pressure hydrocephalus
+∞
11.6
11
*
G942, I601,
ICD-10 Finland
+∞
11.6
11
*
Z51.5
ICD-10 Finland
Palliative care
3.9
11.1
36
105
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.6
10.7
27
65
NK6AI
NOMESCO Finland
Other cone beam scan
115.4
10.5
11
*
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
3.1
10.4
52
201
PA2BD
NOMESCO Finland
Extensive CT angiography of brain
12.1
10.3
18
16
I61.9
ICD-10 Finland
Intracerebral haemorrhage, unspecified
12.1
10.3
18
16
D43.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Brain, supratentorial
42.2
10.1
12
*
ZXC86
NOMESCO Finland
Use of endoscopic device
42.2
10.1
12
*
PA2AC
NOMESCO Finland
Cerebral angiography with X-ray
21.3
9.9
14
7
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
14.3
9.8
16
12
L28
ICPC
Limited function/disability (L)
2.8
9.6
60
261
G40.9
ICD-10 Finland
Epilepsy, unspecified
5.5
9.5
19
37
S06.5
ICD-10 Finland
Traumatic subdural haemorrhage
9.4
9.5
19
22
G941, D431,
ICD-10 Finland
+∞
9.4
9
*
G942, I690,
ICD-10 Finland
+∞
9.4
9
*
G942, I609,
ICD-10 Finland
+∞
9.4
9
*
Z98.2
ICD-10 Finland
Presence of cerebrospinal fluid drainage device
+∞
9.4
9
*
Y83.1
ICD-10 Finland
Surgical operation with implant of artificial internal device as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
12.2
9.2
16
14
JDB10
NOMESCO Finland
Percutaneous gastrostomy
14.9
8.8
14
10
XX1ZW
NOMESCO Finland
Very extensive written report from radiologist
28.8
8.6
11
*
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.4
8.5
83
444
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
5.0
8.5
19
41
D43.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Brain, infratentorial
93.5
8.5
9
*
I60.8
ICD-10 Finland
Other subarachnoid haemorrhage
93.5
8.5
9
*
AAB30
NOMESCO Finland
Evacuation of spontaneous intracranial haematoma
93.5
8.5
9
*
AA5BD
NOMESCO Finland
CT of cerebral ischaemia
10.1
8.4
16
17
AA1CD
NOMESCO Finland
Very extensive CT of head and brain
10.1
8.4
16
17
PA7BD
NOMESCO Finland
CT angiography of neck and brain
11.4
8.4
15
14
WX402
NOMESCO Finland
General anaesthesia
2.5
8.4
67
327
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
3.4
8.3
33
110
U04
ICPC
Incontinence urine
4.3
8.3
22
55
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
8.7
8.3
17
21
SPAT1216
SPAT
Assessment of functional ability
2.8
8.2
48
200
ZXE10
NOMESCO Finland
More than one and less than three hours
2.3
8.2
97
563
N29
ICPC
Neurological sympt/complt other
12.4
8.2
14
12
I60.3
ICD-10 Finland
Subarachnoid haemorrhage from posterior communicating artery
34.8
8.1
10
*
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
3.6
8.1
29
90
R56.8
ICD-10 Finland
Other and unspecified convulsions
4.3
8.1
22
56
D21
ICPC
Swallowing problem
10.0
7.9
15
16
Y83.9
ICD-10 Finland
Surgical procedure, unspecified as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
4.8
7.8
18
40
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.4
7.8
30
98
N03AF02
ATC
oxcarbazepine; oral
6.6
7.7
19
31
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
4.1
7.7
22
58
N28
ICPC
Limited function/disability (N)
12.5
7.7
13
11
ZXC95
NOMESCO Finland
Use of surgical navigator
12.5
7.7
13
11
G00.9
ICD-10 Finland
Bacterial meningitis, unspecified
82.8
7.5
8
*
SPAT1224
SPAT
Implementation of speech therapy rehabilitation plan
11.4
7.4
13
12
G942, I606,
ICD-10 Finland
+∞
7.3
7
*
G942, I600,
ICD-10 Finland
+∞
7.3
7
*
I61.8
ICD-10 Finland
Other intracerebral haemorrhage
+∞
7.3
7
*
I63.8
ICD-10 Finland
Other cerebral infarction
20.9
7.2
10
5
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
3.4
7.1
27
87
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.9
7.0
36
140
SPAT1231
SPAT
Assessment of adjustments needed in living environment
9.8
6.9
13
14
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
11.5
6.9
12
11
C71.90
ICD-10 Finland
Malignant tumor in unspecified localization in the brain without histology
41.4
6.8
8
*
Z3231
NOMESCO Finland
Registered nurse
0.2
6.7
12
442
ZXD00
NOMESCO Finland
Emergency procedure
6.6
6.6
16
26
AWB00
NOMESCO Finland
Reoperation for superficial infection in surgery of the nervous system
71.9
6.5
7
*
GBB00
NOMESCO Finland
Tracheostomy
14.9
6.5
10
7
D33.30
ICD-10 Finland
Acoustic neuroma
14.9
6.5
10
7
Z46.8
ICD-10 Finland
Fitting and adjustment of other specified devices
6.9
6.5
15
23
G941, C7931,
ICD-10 Finland
+∞
6.3
6
*
G941, D3330,
ICD-10 Finland
+∞
6.3
6
*
AAA10
NOMESCO Finland
Biopsy through craniotomy
+∞
6.3
6
*
AAA27
NOMESCO Finland
Insertion of intracerebral pressure monitoring device
+∞
6.3
6
*
AAF15
NOMESCO Finland
Ventriculoatrial shunt
+∞
6.3
6
*
G81.1
ICD-10 Finland
Spastic hemiplegia
+∞
6.3
6
*
I60.4
ICD-10 Finland
Subarachnoid haemorrhage from basilar artery
+∞
6.3
6
*
G942, I603,
ICD-10 Finland
+∞
6.3
6
*
G40.10
ICD-10 Finland
Simple partial seizures
27.5
6.3
8
*
XCK00
NOMESCO Finland
Perimetry
3.6
6.2
21
63
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
3.7
6.2
20
58
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.5
6.1
43
195
R41.0
ICD-10 Finland
Disorientation, unspecified
6.4
6.1
15
25
SPAT1304
SPAT
Counselling and guidance related to ageing
3.4
6.1
23
74
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
93
15
107.75
175.75
3.8
1.0
—
—
—
0
0
88
14
105.05
166.21
2.9
1.0
2.99
1.93
mmol/l
3.68
83
14
57
51
14.80
56.83
2.8
1.7
—
—
—
0
0
39
7
67.42
34.56
3.8
1.0
—
—
—
0
0
151
751
4.32
23.08
4.2
4.0
41.46
30.22
ng/l
0.37
125
534
37
66
6.55
20.71
1.6
2.2
—
—
—
0
0
65
194
4.36
20.16
4.1
3.7
—
—
—
0
0
33
65
5.81
16.59
1.6
1.8
—
—
—
0
0
41
113
4.24
13.80
6.1
4.4
2.42
1.66
mmol/l
0.64
32
81
102
586
2.40
9.04
5.7
3.3
5.95
0.00
estimate
0.49
42
177
98
570
2.31
8.26
5.9
4.1
0.00
0.00
estimate
-0.00
51
201
18
40
4.82
7.80
1.8
3.3
29.44
35.30
umol/l
0.69
18
33
20
49
4.39
7.72
2.5
2.0
140.43
129.06
g/l
1.59
14
35
132
896
2.21
7.35
4.3
2.9
—
—
estimate
—
0
0
11
7
16.45
7.31
2.2
1.0
—
—
—
0
0
42
177
2.70
7.00
13.5
7.8
6.57
9.52
mmol/l
3.08
42
169
163
1903
0.42
6.41
5.7
6.1
2.69
2.73
mmol/l
0.19
145
1766
6
0
+∞
6.28
5.7
0.0
0.07
—
ug/l
—
6
0
13
23
5.94
5.15
3.3
1.7
20.69
18.25
ug/l
0.10
13
23
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
9
9
10.37
5.07
1.3
1.0
—
—
—
0
0
160
1258
2.03
5.04
7.6
4.5
399.64
223.53
e6/l
0.28
11
19
155
1810
0.50
4.80
7.9
6.6
40.04
39.42
mmol/mol
0.36
137
1701
163
1872
0.48
4.80
5.3
5.2
1.41
1.49
mmol/l
1.56
146
1732
16
48
3.52
4.70
2.1
1.5
—
—
—
0
0
67
407
1.93
4.53
1.4
1.9
521.98
35135592.35
pmol/l
0.50
53
333
57
329
1.99
4.46
2.2
2.0
—
—
—
0
0
135
1025
1.84
4.45
12.1
8.1
1.22
1.21
mmol/l
0.24
101
881
165
1877
0.50
4.34
5.3
5.3
4.55
4.68
mmol/l
0.76
146
1743
55
861
0.52
4.32
2.3
2.0
1.51
1.37
mmol/l
0.66
37
718
109
793
1.75
4.00
6.4
3.8
0.09
0.00
estimate
0.68
46
176
9
15
6.21
3.85
1.2
1.1
—
—
—
0
0
71
461
1.80
3.82
4.5
2.5
—
—
—
0
0
15
356
0.38
3.47
3.3
2.9
1.11
0.94
e6/l
—
10
188
119
924
1.64
3.17
10.4
7.1
1.21
1.21
mmol/l
0.02
109
850
29
148
2.11
3.13
2.1
1.5
—
—
—
0
0
13
45
3.01
3.08
3.9
4.2
26.00
26.94
mg/l
—
8
31
87
633
1.62
2.96
3.3
2.5
47.05
69.30
u/l
1.55
80
588
133
1077
1.61
2.87
10.8
7.0
8.57
10.89
umol/l
4.11
126
1030
184
1987
0.51
2.85
16.8
12.7
27.94
25.97
u/l
0.85
176
1934
10
28
3.69
2.82
1.1
1.6
—
—
—
0
0
10
28
3.69
2.82
1.2
1.6
—
—
—
0
0
10
28
3.69
2.82
1.2
1.6
—
—
—
0
0
10
28
3.69
2.82
1.2
1.6
—
—
—
0
0
10
28
3.69
2.82
1.2
1.6
—
—
—
0
0
10
29
3.56
2.73
1.2
1.6
—
—
—
0
0
9
24
3.86
2.70
1.4
1.3
—
—
—
0
0
12
41
3.04
2.66
10.3
2.6
10.88
8.13
pmol/l
0.42
12
41
42
260
1.76
2.58
4.1
4.8
32.32
32.10
%
0.05
31
162
5
7
7.28
2.56
1.6
1.0
—
—
—
0
0
14
57
2.56
2.50
1.5
1.2
—
—
—
0
0
19
90
2.22
2.47
1.9
1.3
—
—
—
0
0
5
8
6.36
2.38
2.8
1.8
—
—
—
0
0
7
17
4.22
2.38
1.0
1.0
—
—
—
0
0
7
18
3.98
2.27
1.3
1.2
—
—
—
0
0
14
61
2.38
2.19
2.4
1.8
—
—
—
0
0
8
25
3.28
2.11
10.3
5.5
203.50
80.27
u/ml
—
8
25
5
10
5.09
2.08
1.2
5.5
191.40
201.50
u/l
—
5
10
5
10
5.09
2.08
1.2
1.6
—
—
—
0
0
5
10
5.09
2.08
1.2
1.6
—
—
—
0
0
170
1851
0.62
2.05
5.0
5.3
6.10
5.95
mmol/l
0.69
145
1698
8
26
3.15
2.03
2.9
1.5
—
—
—
0
0
7
21
3.41
1.98
1.0
1.0
—
—
—
0
0
7
21
3.41
1.98
1.0
1.0
—
—
—
0
0
162
1779
0.65
1.97
4.8
4.4
1.32
1.28
mmol/l
0.30
146
1631
16
297
0.50
1.93
3.1
3.0
0.81
0.76
ug/l
0.09
11
190
6
17
3.60
1.85
1.0
1.0
—
—
—
0
0
77
596
1.45
1.81
3.1
3.4
674.97
1069.35
ng/l
1.79
69
501
7
23
3.11
1.81
1.7
2.1
—
—
—
0
0
123
1045
1.41
1.70
6.4
4.0
0.00
7.48
estimate
0.50
61
217
122
1037
1.40
1.67
6.4
4.0
0.00
0.00
estimate
-0.00
56
209
5
14
3.63
1.62
6.4
2.6
—
—
—
0
0
38
531
0.66
1.57
3.3
3.1
335.45
339.04
umol/l
0.09
33
465
123
1055
1.38
1.55
6.4
4.0
0.00
0.00
estimate
-0.00
56
203
13
65
2.06
1.52
1.3
1.4
—
—
—
0
0
14
73
1.98
1.47
2.4
2.7
—
—
—
0
0
19
111
1.78
1.44
1.3
1.6
—
—
—
0
0
7
29
2.46
1.40
3.4
1.4
—
—
—
0
0
71
869
0.73
1.38
1.9
2.1
104.75
98.85
pmol/l
0.42
46
425
6
23
2.65
1.37
1.7
2.1
—
—
—
0
0
5
17
2.98
1.36
1.2
1.2
—
—
—
0
0
5
17
2.98
1.36
1.0
1.2
69.80
66.42
u/l
—
5
12
168
1803
0.70
1.35
6.2
5.5
1.73
1.94
mu/l
1.70
147
1651
0
41
0.00
1.32
0.0
1.1
—
15.11
—
0
7
44
325
1.44
1.30
2.0
1.7
1412.22
1242.72
nmol/l
0.53
36
240
26
379
0.64
1.30
1.3
1.3
1.39
12.66
u/ml
—
8
136
26
376
0.65
1.25
1.7
1.6
—
—
—
0
0
5
19
2.67
1.22
1.4
1.3
—
—
—
0
0
12
64
1.93
1.20
2.8
1.8
—
—
—
0
0
8
38
2.15
1.19
3.6
1.9
—
—
—
0
0
28
394
0.67
1.18
4.5
4.6
21.54
22.66
%
0.21
16
187
30
414
0.68
1.15
1.3
1.3
75.16
31.94
iu/ml
—
7
141
104
1182
0.77
1.12
2.9
3.1
—
—
—
0
0
8
146
0.53
1.08
9.5
3.8
23.95
24.22
mmol/l
—
8
146
101
879
1.28
1.01
7.7
5.0
33.49
35.92
g/l
3.24
91
839
15
92
1.68
1.00
13.1
10.0
1.66
1.55
%
0.28
15
86
10
171
0.56
0.96
1.2
1.4
—
—
—
0
0
6
27
2.26
0.94
1.3
1.4
—
—
—
0
0
29
385
0.72
0.90
4.1
3.7
1239.00
207.95
ng/l
0.40
17
300
40
504
0.75
0.89
1.4
1.3
0.71
1.92
u/ml
1.36
14
127
11
64
1.76
0.88
1.5
1.5
—
—
—
0
0
6
31
1.96
0.85
6.0
1.6
10.50
10.38
mmol/l
—
6
31
161
1502
1.28
0.83
12.0
8.6
84.92
81.37
u/l
0.31
153
1416
81
925
0.80
0.82
4.0
3.2
142.20
113.75
ug/l
0.54
71
868
0
25
0.00
0.79
0.0
1.1
—
7.39
—
0
18
139
1496
0.80
0.79
5.1
4.5
12.52
12.07
mm/h
0.14
129
1378
17
240
0.68
0.75
3.5
1.8
—
—
—
0
0
17
117
1.49
0.74
12.5
11.1
25.59
24.63
mmol/l
0.58
17
111
7
40
1.77
0.72
1.9
1.3
—
—
—
0
0
5
26
1.94
0.71
1.6
1.2
—
—
—
0
0
139
1287
1.22
0.70
5.2
3.4
60.63
46.29
u/l
0.69
130
1221
0
23
0.00
0.58
0.0
1.1
—
3.26
—
0
11
0
23
0.00
0.58
0.0
1.7
—
—
—
0
0
8
54
1.50
0.58
2.0
1.4
—
—
—
0
0
54
466
1.21
0.55
2.0
1.8
1.21
1.38
mg/l
0.14
45
381
6
38
1.60
0.55
2.3
1.8
—
—
—
0
0
40
473
0.81
0.54
6.2
3.9
1.02
1.02
kg/l
0.08
32
313
17
128
1.36
0.49
2.4
2.5
—
18.91
—
0
7
19
149
1.30
0.43
1.5
2.3
6.99
4.96
ug/l
0.19
14
129
8
56
1.44
0.43
1.9
2.0
—
—
—
0
0
0
17
0.00
0.41
0.0
1.0
—
40.34
—
0
12
0
17
0.00
0.41
0.0
1.0
—
575.92
—
0
12
5
35
1.44
0.39
3.8
1.5
—
—
—
0
0
0
19
0.00
0.39
0.0
1.3
—
—
—
0
0
14
179
0.77
0.37
3.2
2.0
—
—
—
0
0
148
1541
0.88
0.37
5.8
4.4
15.47
14.84
pmol/l
2.19
133
1410
16
127
1.28
0.34
5.2
3.3
35.31
45.03
u/ml
0.25
16
121
6
88
0.67
0.33
1.7
3.0
6.67
2310.69
u/ml
—
6
77
7
54
1.31
0.30
1.0
1.2
—
—
—
0
0
7
55
1.28
0.30
2.1
1.7
—
—
—
0
0
18
216
0.82
0.30
2.0
6.8
—
—
—
0
0
11
137
0.79
0.25
3.1
2.6
116.91
175.11
ng/l
0.62
11
126
22
254
0.85
0.25
3.0
1.8
—
—
—
0
0
26
293
0.87
0.22
10.5
7.0
104.73
104.08
mmol/l
0.32
26
293
73
688
1.09
0.21
4.4
3.1
31.10
30.54
u/l
0.07
68
648
0
10
0.00
0.21
0.0
1.7
—
—
—
0
0
17
145
1.19
0.21
1.4
1.2
73.67
164.44
u/ml
—
6
56
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
33.83
—
0
6
0
13
0.00
0.21
0.0
3.0
—
792.62
—
0
13
6
49
1.23
0.20
2.3
1.8
—
—
—
0
0
14
163
0.85
0.18
3.1
1.8
—
—
—
0
0
21
236
0.88
0.17
6.3
4.3
5.73
5.65
kpa
0.17
21
231
65
685
0.93
0.17
4.6
4.1
7.00
9.83
mg/mmol
0.24
41
416
18
203
0.88
0.16
6.8
3.4
4.26
4.51
kpa
0.44
18
198
24
219
1.11
0.13
16.3
10.5
15.50
12.37
kpa
1.08
24
212
24
219
1.11
0.13
16.3
10.5
5.04
5.16
kpa
0.39
24
212
95
922
1.05
0.11
2.9
2.6
80.88
77.55
nmol/l
0.44
86
831
62
595
1.06
0.11
1.6
1.7
20.76
21.56
nmol/l
0.14
52
487
5
46
1.09
0.09
2.6
1.6
—
—
—
0
0
21
227
0.92
0.09
5.1
4.4
85.76
8.62
ug/l
0.48
16
189
5
61
0.82
0.08
1.4
1.8
—
—
—
0
0
10
112
0.89
0.07
28.1
13.9
15.83
15.61
%
—
10
107
188
1894
0.94
0.06
31.4
16.2
19.85
22.74
mg/l
0.63
180
1538
30
314
0.95
0.06
1.8
1.4
—
—
—
0
0
73
716
1.03
0.04
3.9
3.4
2.35
2.36
mmol/l
0.21
68
653
10
108
0.92
0.03
1.1
1.0
—
—
—
0
0
52
514
1.02
0.00
2.5
2.2
4.11
2.98
mg/l
1.48
45
446
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.9
—
42.80
—
0
9
0
7
0.00
-0.00
0.0
1.0
—
10.54
—
0
7
5
54
0.92
-0.00
1.2
1.4
—
2.76
—
0
10
0
5
0.00
-0.00
0.0
1.0
—
0.03
—
0
5
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint G6_HCINOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_HCINOTH | 5.144 [3.85, 6.87] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.055 |
During the follow-up period (1.1.1998 — 31.12.2019), 238 out of 716 females with G6_HCINOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_HCINOTH | 5.443 [3.94, 7.52] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.055 |
During the follow-up period (1.1.1998 — 31.12.2019), 203 out of 639 males with G6_HCINOTH died.
Mortality risk
Mortality risk for people of age
years, who have G6_HCINOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.386% | 0.987% |
| 5 | 3.0% | 6.198% |
| 10 | 6.745% | 15.626% |
| 15 | 12.709% | 27.03% |
| 20 | 20.651% | 42.374% |
Relationships between endpoints
↥Index endpoint: G6_HCINOTH – Hydrocephalus in other diseases
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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