Lesion of medial popliteal nerve

G6_FEMMEPOP

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — G57.4 Hospital discharge: ICD-9 — 3554 Cause of death: ICD-10 — G57.4 Cause of death: ICD-9 — 3554 2 out of 7 registries used, show all original rules.	163
4. Check minimum number of events None	163
5. Include endpoints None	163
6. Filter based on genotype QC (FinnGen only)	147

Control definitions (FinnGen only)

Control exclude: G6_NERPLEX

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: G57
Name in latin: Morbositas nervi tibialis

NAME	G6_FEMMEPOP
CONTROL_EXCLUDE	G6_NERPLEX
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	G574
HD_ICD_9	3554
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	G574
COD_ICD_9	3554
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Lesion of medial popliteal nerve based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	945	503	441
Only index persons	875	470	405
Unadjusted period prevalence (%)
Whole population	0.01	0.01	0.01
Only index persons	0.02	0.02	0.02
Median age at first event (years)
Whole population	50.49	52.31	48.40
Only index persons	49.98	51.67	48.03

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	147	96	51
Unadjusted period prevalence (%)	0.03	0.03	0.02
Median age at first event (years)	54.04	53.93	54.26

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
153: Matched controls
1530

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

G57.4

ICD-10 Finland

Lesion of medial popliteal nerve

+∞

193.7

142

G57.3

ICD-10 Finland

Lesion of lateral popliteal nerve

+∞

39.3

ACC59

NOMESCO Finland

Decompression and freeing of adhesions of peripheral nerve: other or unspecified

192.7

30.9

N03AX16

ATC

[U] pregabalin

5.2

21.4

182

N03AX12

ATC

[U] gabapentin; oral

5.6

20.3

119

M79.6

ICD-10 Finland

Pain in limb

4.6

18.5

104

481

N02BF01

ATC

gabapentin; oral

5.6

15.9

G56.0

ICD-10 Finland

Carpal tunnel syndrome

14.0

15.8

N06AX21

ATC

duloxetine; oral

5.1

14.9

N02AX02

ATC

tramadol; systemic, rectal

3.7

14.2

436

M19.0

ICD-10 Finland

Primary arthrosis of other joints

5.0

13.8

ACC51

NOMESCO Finland

Release of median nerve

153.0

13.7

M77.4

ICD-10 Finland

Metatarsalgia

5.5

12.7

Z03.9

ICD-10 Finland

Observation for suspected disease or condition, unspecified

3.8

11.4

148

L17

ICPC

Foot/toe symptom/complaint

3.2

11.2

326

3554A

ICD-9 Finland

Mononeuritis of lower limb, Lesion of medial popliteal nerve

+∞

10.5

M25.5

ICD-10 Finland

Pain in joint

3.0

10.1

379

N02AE01

ATC

buprenorphine; parenteral, sublingual, transdermal

4.0

9.8

G57.8

ICD-10 Finland

Other mononeuropathies of lower limb

58.8

9.8

XA402

NOMESCO Finland

ENMG

19.1

9.6

R5110, ,

SPAT

4.5

9.6

N02AA59

ATC

codeine, combinations excl. psycholeptics; systemic

2.9

9.4

498

R52.2

ICD-10 Finland

Other chronic pain

8.9

9.2

G57.6

ICD-10 Finland

Lesion of plantar nerve

20.1

9.1

N06AA09

ATC

amitriptyline; systemic

4.1

9.0

NH3AA

NOMESCO Finland

Foot and toes X-ray examination

4.5

9.0

SPAT1230

SPAT

Aid fitting and borrowing and monitoring of use

3.6

8.8

113

G57.5

ICD-10 Finland

Tarsal tunnel syndrome

+∞

8.4

ZXD10

NOMESCO Finland

Scheduled procedure

2.6

7.9

394

N05CD07

ATC

temazepam; oral

3.7

7.8

NA3BG

NOMESCO Finland

Lumbar spine MRI examination with high intensity magnet

3.8

7.5

NH1BG

NOMESCO Finland

Ankle and foot MRI examination with high intensity magnet

16.8

7.3

J01MA14

ATC

moxifloxacin; systemic

3.7

7.3

L28

ICPC

Limited function/disability (L)

3.0

7.3

158

N02AJ06

ATC

codeine and paracetamol; systemic

2.5

7.2

491

T93.2

ICD-10 Finland

Sequelae of other fractures of lower limb

21.2

7.2

WX700

NOMESCO Finland

Respiratory and circulatory monitoring

3.1

7.1

123

NG1AA

NOMESCO Finland

Knee X-ray examination without contrast

3.3

6.9

SPAT1229

SPAT

Assessment of need for aid

4.4

6.8

B01AB05

ATC

enoxaparin; parenteral

2.5

6.7

321

ZXA05

NOMESCO Finland

Left side

2.6

6.5

229

ACC54

NOMESCO Finland

Release of peroneal nerve

+∞

6.3

ACC55

NOMESCO Finland

Release of tibial nerve

+∞

6.3

ACB19

NOMESCO Finland

Excision of lesion of peripheral nerve other or unspecified

+∞

6.3

M01AH05

ATC

etoricoxib; oral

2.5

6.3

111

780

NH1AA

NOMESCO Finland

Ankle X-ray examination without contrast

4.0

6.3

ZXA00

NOMESCO Finland

Right side

2.5

6.2

233

WX320

NOMESCO Finland

Spinalanesthesy

2.6

6.2

226

NHU20

NOMESCO Finland

Removal of internal fixation device from ankle or foot

6.5

6.2

Z3231

NOMESCO Finland

Registered nurse

2.4

6.1

280

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3018418) pH of Serum or Plasma

422

2.40

6.51

3.2

3.8

7.40

7.39

0.89

289

(3002582) Erythrocytes [#/volume] in Urine

436

2.29

5.89

3.5

2.9

12.44

51.19

e6/l

1.75

325

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

655

2.25

5.47

6.8

6.7

1.22

mmol/l

0.18

559

(3018095) Leukocytes [#/volume] in Urine

510

2.19

5.37

4.5

3.6

115.20

100.25

e6/l

0.06

349

(40768797) Stomach Pathology biopsy report

181

2.38

4.60

1.2

1.3

—

(3007853) Bacteria identified in Skin by Aerobe culture

140

2.52

4.57

1.7

1.5

—

(3004588) Protein electrophoresis panel - Serum or Plasma

2.96

4.47

2.1

—

(3001604) Monocytes [#/volume] in Blood

677

2.06

4.46

5.2

6.4

0.56

e9/l

0.04

586

(3006315) Basophils [#/volume] in Blood

678

2.06

4.43

5.3

6.5

0.04

e9/l

0.03

585

(3019198) Lymphocytes [#/volume] in Blood

690

2.05

4.36

5.2

6.5

1.84

2.01

e9/l

0.50

610

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

320

2.06

4.16

2.4

2.1

2.65

2.93

mg/l

0.42

275

(3037522) Nuclear Ab [Titer] in Serum

183

2.26

4.07

1.3

1.4

571.43

524.65

titre

—

(3016888) Borrelia burgdorferi IgG Ab [Units/volume] in Serum

2.77

4.00

1.3

1.2

—

45.04

—

(3024561) Albumin [Mass/volume] in Serum or Plasma

571

1.94

3.93

4.1

4.3

36.28

36.06

g/l

0.14

541

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

254

2.09

3.91

4.6

3.7

143.49

390.82

ng/l

0.64

195

(3042936) Bacteria identified in Isolate by Culture

186

2.22

3.91

2.5

2.0

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

463

1.94

3.90

3.7

3.0

—

(3013115) Eosinophils [#/volume] in Blood

706

1.97

3.90

5.3

6.9

0.19

e9/l

0.05

616

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

582

1.93

3.88

2.2

1.9

91.62

100.34

pmol/l

0.85

273

(42870588) Differential panel, method unspecified - Blood

433

1.92

3.73

4.3

6.1

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

220

2.11

3.70

3.6

2.5

1.08

0.85

e6/l

0.23

109

(3013650) Neutrophils [#/volume] in Blood by Automated count

101

764

1.95

3.68

6.0

10.5

4.14

3.98

e9/l

0.29

659

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

593

1.82

3.31

3.2

2.5

—

estimate

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

603

1.82

3.29

2.6

2.4

80.83

78.38

nmol/l

0.27

539

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

126

2.28

3.26

2.8

2.4

35.90

28.07

u/l

0.72

101

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

230

2.00

3.26

1.4

1.3

1.09

12.38

u/ml

2.42

(3001334) Neutrophil cytoplasmic Ab [Units/volume] in Serum

3.14

3.22

1.5

1.4

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

4.71

3.16

1.4

1.1

—

(3013826) Glucose [Moles/volume] in Serum or Plasma

750

1.80

3.03

7.3

4.6

6.95

6.56

mmol/l

0.82

706

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

146

1329

3.15

2.94

22.9

14.0

23.00

23.99

mg/l

0.12

131

1055

(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis

3.75

2.84

2.3

1.2

0.00

g/l

—

(3030467) Casts [#/volume] in Urine by Automated count

366

1.78

2.83

3.9

2.7

0.25

0.33

e6/l

0.30

255

(3023368) Bacteria identified in Blood by Culture

341

1.80

2.80

4.5

4.3

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

2.32

2.64

1.6

1.5

—

(21494890) Protein electrophoresis panel - 24 hour Urine

7.33

2.57

1.4

1.0

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

195

1.88

2.45

4.0

2.8

3.41

3.01

e6/l

—

(3021960) Folate [Moles/volume] in Serum or Plasma

362

1.71

2.44

1.6

19.92

21.96

nmol/l

0.45

299

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

322

1.71

2.34

1.2

1.3

0.89

1.73

u/ml

0.72

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

159

1.93

2.34

2.5

1.8

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

3.23

2.26

1.6

1.1

—

(3044640) Blood type and Crossmatch panel - Blood

405

1.65

2.23

3.2

2.2

—

(3042111) Morphology [Interpretation] in Bone marrow Narrative

3.81

2.18

1.4

2.5

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

311

1.69

2.17

4.0

2.0

—

(3021589) Normoblasts [#/volume] in Blood

603

1.60

2.15

9.1

11.4

0.01

0.00

e9/l

0.46

485

(3017143) Hepatitis C virus Ab [Presence] in Serum

134

1.94

2.10

1.8

1.7

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

165

1.85

2.09

2.6

1.8

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

121

1047

1.74

2.07

4.6

4.3

14.37

14.71

pmol/l

0.91

116

944

(40764999) Glomerular filtration rate [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)/1.73 sq M

143

1307

2.44

2.06

19.7

13.8

81.75

81.71

ml/min/173m2

0.01

135

1195

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

4.12

2.06

2.2

1.0

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

4.12

2.06

2.2

1.0

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

215

1.75

2.02

2.9

1.9

—

(3019977) pH of Arterial blood

144

1.88

2.00

11.9

7.6

7.41

7.43

0.52

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

317

1.65

2.00

1.9

1.6

0.61

1.30

mg/l

2.36

264

(3044927) Protein electrophoresis panel - Urine

4.66

1.95

1.0

1.1

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

2.15

1.93

12.2

8.4

24.81

25.10

mmol/l

0.11

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.07

1.88

1.6

1.7

—

(3026008) Bacteria identified in Urine by Culture

402

1.57

1.87

3.8

2.8

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

262

1.66

1.86

1.5

1.3

14.58

25.27

iu/ml

—

(40758558) Short blood count panel - Blood

403

1.57

1.85

4.1

6.1

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

4.27

1.84

1.2

1.3

—

(3000494) Fungus identified in Specimen by Culture

165

1.77

1.80

1.6

1.5

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

138

1258

1.99

1.77

5.8

5.3

1.86

1.94

mu/l

0.35

133

1152

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

100

844

1.53

1.71

3.1

3.0

—

(3002385) Erythrocyte [DistWidth] in Red Blood Cells

127

1135

1.70

1.67

22.8

18.3

13.70

13.61

0.34

127

1123

(3003191) Choriogonadotropin [Presence] in Serum or Plasma

2.88

1.67

4.0

1.8

—

(3009508) Creatinine [Moles/volume] in Urine

457

1.51

1.67

3.8

3.1

7.53

7.80

mmol/l

0.20

380

(3027946) Carbon dioxide [Partial pressure] in Arterial blood

145

1.78

1.66

12.3

7.4

5.19

5.03

kpa

0.33

140

(3027801) Oxygen [Partial pressure] in Arterial blood

145

1.78

1.66

12.3

7.4

13.31

12.04

kpa

0.48

140

(21494434) Karyotype in Bone marrow

3.65

1.63

1.2

1.1

—

(40769539) Bacteria identified based on 16S rRNA gene [Identifier] in Specimen by Sequencing

2.58

1.62

2.0

1.5

—

(3024928) Oxygen saturation in Venous blood

2.58

1.62

2.5

2.7

70.27

61.98

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.02

1.60

1.8

1.7

—

(3007164) IgA [Mass/volume] in Serum or Plasma

289

1.57

1.60

1.3

1.4

2.67

2.28

g/l

0.52

171

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

2.50

1.56

1.4

—

(3032080) INR in Blood by Coagulation assay

605

1.47

1.55

14.9

10.3

1.13

1.20

inr

0.69

487

(44816559) Phosphatidylethanol [Mass/volume] in Blood

2.16

1.54

2.7

1.6

0.46

0.31

mg/l

—

(3026389) Candida sp identified in Specimen by Organism specific culture

3.41

1.53

1.6

1.5

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

2.57

1.47

1.6

1.1

—

(3010566) Parathyrin.intact [Moles/volume] in Serum or Plasma

2.57

1.47

2.3

2.9

8.36

7.68

pmol/l

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

167

1.67

1.46

2.0

1.5

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

209

1.61

1.45

2.3

1.8

—

(36660697) Celiac disease serology panel - Serum

104

1.83

1.44

1.4

1.2

—

(3020682) Albumin/Creatinine [Ratio] in Urine

450

1.47

1.44

4.5

3.9

2.04

6.77

mg/mmol

2.08

270

(3019309) Folate [Moles/volume] in Red Blood Cells

193

1.62

1.43

1.5

1.6

969.10

1222.81

nmol/l

1.20

144

(3003694) ABO and Rh group [Type] in Blood

342

1.49

1.40

1.3

1.4

—

(3028271) Lactate [Moles/volume] in Capillary blood

3.00

1.37

1.4

2.2

2.80

1.44

mmol/l

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

230

1.55

1.35

1.5

—

(3015736) pH of Urine

589

1.42

1.32

3.9

3.0

5.97

6.21

1.05

333

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

140

1305

1.86

1.32

5.5

5.0

6.13

5.88

mmol/l

1.07

135

1201

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

2.43

1.31

1.5

—

(3012516) Albumin [Mass/volume] in Urine

439

1.43

1.29

4.4

3.2

24.56

46.22

mg/l

0.92

273

(3023410) Appearance of Cerebral spinal fluid

2.84

1.29

1.2

1.1

—

(3021601) Nitrite [Presence] in Urine by Test strip

728

1.41

1.29

4.4

3.4

0.00

estimate

—

154

(3014576) Chloride [Moles/volume] in Serum or Plasma

182

1.59

1.27

11.1

6.5

103.22

104.19

mmol/l

0.43

182

(3016879) Cocaine [Presence] in Urine

2.22

1.23

1.5

1.4

—

(3023511) Choriogonadotropin [Units/volume] in Urine

2.68

1.22

1.2

1.4

—

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

137

1275

1.71

1.22

4.4

4.3

1.50

1.27

mmol/l

2.91

132

1176

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

2.16

1.20

2.0

1.9

—

(3009261) Glucose [Presence] in Urine by Test strip

744

1.39

1.20

4.5

3.5

0.00

0.02

estimate

—

144

(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction

143

1.63

1.20

3.9

6.2

228.91

248.44

u/l

0.29

135

(3023602) Cholesterol in HDL [Moles/volume] in Serum or Plasma

142

1337

1.86

1.17

5.1

1.48

1.50

mmol/l

0.17

137

1236

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

2.11

1.17

2.1

2.2

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

484

1.39

1.16

4.0

3.7

1065.37

31.12

ng/l

0.50

336

(3013290) Carbon dioxide [Partial pressure] in Blood

2.55

1.16

3.6

3.4

5.04

5.14

kpa

—

(3027315) Oxygen [Partial pressure] in Blood

2.55

1.16

3.6

3.4

8.90

7.91

kpa

—

(3035350) Ketones [Presence] in Urine by Test strip

737

1.38

1.15

4.4

3.4

0.00

estimate

-0.00

156

(3022621) pH of Urine by Test strip

112

1.69

1.15

2.9

2.1

6.08

6.19

0.14

(3027008) Opiates [Presence] in Urine

2.05

1.14

1.5

1.4

—

(3028300) Cannabinoids [Presence] in Urine

2.05

1.14

1.5

1.4

—

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

2.32

1.12

1.6

1.7

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

2.32

1.12

1.6

1.4

—

(3031478) Chlamydophila pneumoniae DNA [Presence] in Specimen by NAA with probe detection

2.32

1.12

1.6

1.7

—

(3028707) Methadone [Presence] in Urine by Screen method

2.43

1.10

1.6

1.3

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

1.97

1.04

1.1

1.5

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

1.95

1.04

2.0

1.8

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

1.99

0.98

1.6

—

(40768804) Tissue Pathology biopsy report

574

1.33

0.96

2.5

2.1

—

(3001308) Cholesterol in LDL [Moles/volume] in Serum or Plasma

143

1361

1.78

0.95

6.4

5.9

2.74

2.77

mmol/l

0.16

137

1258

(3000764) Benzodiazepines [Presence] in Urine

1.95

0.90

1.5

1.4

—

(3027944) Amphetamines [Presence] in Urine

1.95

0.90

1.5

1.4

—

(3019150) Specific gravity of Urine by Refractometry

314

1.37

0.89

4.0

3.4

1.02

kg/l

0.69

212

(3044290) Cell count panel - Cerebral spinal fluid

2.04

0.88

1.0

1.1

—

(3011288) Drugs identified in Urine by Screen method Nominal

2.04

0.88

1.7

1.5

—

(3010421) pH of Blood

1.97

0.85

4.5

3.7

7.41

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

1.70

0.84

2.5

3.4

24.72

24.65

mmol/l

0.04

(3022145) Colonoscopy Study observation

158

1.46

0.80

1.3

—

(3012544) pH of Venous blood

133

1.49

0.78

2.2

3.7

7.39

7.40

0.05

(3037756) Immunofixation for Serum or Plasma

1.80

0.77

2.0

1.6

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

1.74

0.77

1.0

1.2

0.93

0.94

g/l

—

(40761536) Microorganisms panel - Urine sediment

108

0.54

0.75

6.8

3.1

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

2.12

0.75

1.8

1.9

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

1.67

0.74

1.1

1.2

—

(3042194) Human metapneumovirus RNA [Presence] in Specimen by NAA with probe detection

1.83

0.73

1.4

1.7

—

(3028026) IgM [Mass/volume] in Serum or Plasma

1.56

0.72

1.3

1.6

0.98

1.51

g/l

0.87

(3007930) Methemoglobin/Hemoglobin.total in Blood

1.59

0.71

5.7

4.2

0.93

0.88

—

(3040853) Adenovirus DNA [Identifier] in Specimen by NAA with probe detection

1.74

0.71

2.4

2.0

—

(3019832) Treponema pallidum Ab [Presence] in Serum

1.54

0.69

2.5

1.7

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

1.70

0.69

1.3

—

(3019230) Fractional oxyhemoglobin in Venous blood

1.88

0.69

1.8

2.0

70.40

63.39

—

(1761868) Lipid panel - Serum or Plasma

585

0.78

0.69

3.5

3.2

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

1.66

0.68

1.6

1.8

—

(3032836) C peptide [Moles/volume] in Serum or Plasma --fasting

1.81

0.67

1.2

2.1

0.97

0.82

nmol/l

—

(3051387) C reactive protein [Mass/volume] in Capillary blood

1.81

0.67

2.4

4.4

17.00

32.14

mg/l

—

(40760892) CBC W Ordered Manual Differential panel - Blood

330

1.29

0.64

5.2

5.9

—

(21494755) Public health laboratory ask at order entry panel

151

0.64

0.63

1.8

1.4

—

(3012336) Haptoglobin [Mass/volume] in Serum or Plasma

1.63

0.63

1.3

2.1

1.71

1.47

g/l

—

(3025130) Human papilloma virus identified in Specimen

1.69

0.62

2.2

1.7

—

(3000991) Gas panel - Venous blood

114

1.45

0.62

15.0

7.8

—

(3026989) Triiodothyronine (T3) Free [Moles/volume] in Serum or Plasma

1.57

0.61

2.8

3.5

4.60

4.45

pmol/l

0.12

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

1.57

0.60

1.1

1.2

1.51

1.53

g/l

—

(40768795) Lymph node Pathology biopsy report

0.00

0.60

0.0

1.0

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

1.74

0.58

1.3

1.5

—

(3049717) Cytology report of Urine Cyto stain

1.69

0.57

2.0

3.0

—

(3023081) Carboxyhemoglobin/Hemoglobin.total in Blood

1.58

0.57

5.3

3.9

1.54

1.58

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.53

0.55

1.2

1.3

—

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

253

1.28

0.54

1.5

1.8

524.88

461.56

pmol/l

0.44

219

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

1.52

0.52

1.8

1.3

—

(3002256) Pathology report gross observation

190

1.31

0.52

1.7

1.3

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

1.55

0.49

3.1

2.5

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

554

1.20

0.48

4.3

3.3

0.22

0.02

estimate

—

128

(4035726) Immunohistochemistry procedure

129

0.68

0.45

1.2

1.5

—

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

1.63

0.43

1.8

1.4

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

149

0.72

0.42

6.8

6.5

—

(4281824) Cell count and differential, peritoneal fluid

0.00

0.41

0.0

1.0

—

(40768800) Prostate Pathology biopsy report

0.00

0.41

0.0

1.3

—

(3028369) Herpes simplex virus 1+2 DNA [Presence] in Specimen by NAA with probe detection

0.00

0.41

0.0

1.2

—

(1617658) Protocol used for examination of sentinel lymph nodes

0.00

0.41

0.0

1.2

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

1.49

0.40

1.0

1.3

—

(3001019) Free T4 and TSH panel - Serum or Plasma

1.33

0.40

2.3

1.5

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

282

1.22

0.40

3.8

4.2

22.79

22.16

—

125

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

0.39

0.0

1.1

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

134

1.30

0.39

2.6

3.1

—

(3019060) Gas panel - Arterial blood

1.32

0.38

6.9

4.6

—

(1002224) Polysomnography panel

1.36

0.37

1.3

1.1

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

125

0.70

0.36

1.6

1.5

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

1.41

0.35

1.2

1.1

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

1.41

0.35

1.2

1.1

—

(42529406) Shigella sp [Presence] in Stool by Culture

1.38

0.35

1.2

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

1.38

0.35

1.0

1.3

—

(3003327) Ova and parasites identified in Stool by Light microscopy

1.38

0.35

1.2

1.6

—

(3017732) Neutrophils [#/volume] in Blood

174

1.24

0.33

2.8

2.7

4.20

5.79

e9/l

0.57

151

(3022313) Gas panel - Capillary blood

1.36

0.31

3.7

3.6

—

(3000492) Spirometry study

139

1.25

0.30

1.4

1.3

—

(4024509) Urine culture

1.29

0.30

1.3

1.7

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.22

0.27

2.3

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

1.21

0.25

2.9

2.4

0.60

0.61

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.20

0.25

2.2

2.4

1.07

1.15

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.30

0.25

1.2

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

1.33

0.23

1.0

2.2

—

(3023421) Hepatitis B virus surface Ab [Units/volume] in Serum

1.26

0.22

1.8

1.2

—

171.13

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

1.26

0.22

1.2

1.5

—

(3049539) Genetic diseases [Identifier] in Blood or Tissue by FISH Nominal

0.00

0.21

0.0

1.0

—

(36305771) Cryptosporidium sp DNA [Presence] in Stool by NAA with probe detection

0.00

0.21

0.0

1.1

—

(37020937) Giardia lamblia DNA [Presence] in Stool by NAA with probe detection

0.00

0.21

0.0

1.1

—

(3052649) Adenosine deaminase [Enzymatic activity/volume] in Serum or Plasma

0.00

0.21

0.0

1.8

—

11.00

—

(40768441) Liver Pathology biopsy report

0.00

0.21

0.0

1.2

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

0.21

0.0

1.2

—

(43055361) Metamyelocytes/Leukocytes [Pure number fraction] in Blood by Manual count

0.00

0.21

0.0

4.1

—

1.25

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

3.7

—

2.77

—

(3004915) Chlamydophila pneumoniae IgA Ab [Units/volume] in Serum

0.00

0.21

0.0

1.2

—

3.62

—

(3019897) Erythrocyte [DistWidth] in Red Blood Cells by Automated count

0.00

0.21

0.0

1.8

—

13.15

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

0.21

0.0

4.5

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.20

0.0

1.9

—

(3014037) CD3+CD4+ (T4 helper) cells/cells in Blood

0.00

0.20

0.0

3.5

—

44.67

—

(3008898) HLA-B27 [Presence]

1.22

0.18

1.1

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.12

0.16

1.0

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

1.16

0.15

1.2

1.3

—

(3029937) Albumin [Presence] in Urine by Test strip

416

0.92

0.14

4.9

3.4

0.00

estimate

-0.00

145

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

117

0.84

0.13

4.5

3.9

1.24

1.23

mmol/l

—

102

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

606

1.07

0.11

1.9

2.0

1.45

1.37

mmol/l

0.33

500

(3030366) Cystatin C [Mass/volume] in Serum or Plasma

1.04

0.09

2.4

1.8

1.05

1.41

mg/l

—

(3004248) Sex hormone binding globulin [Moles/volume] in Serum or Plasma

1.12

0.09

1.7

2.0

42.33

36.98

nmol/l

—

(40768443) Skin Pathology biopsy report

1.07

0.09

1.2

1.1

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

214

0.92

0.07

2.1

2.9

0.59

0.71

ug/l

0.38

132

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

119

1.10

0.06

3.4

2.0

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

133

1.06

0.01

3.4

2.1

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

243

1.03

0.01

1.9

1.6

—

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

119

1.01

0.00

1.2

2.3

0.20

0.22

g/l

0.48

112

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

137

1.02

0.00

1.7

1.4

—

(3041096) Erythrocytes [Presence] in Urine by Automated

417

1.01

0.00

4.0

3.0

0.00

estimate

—

124

(4010399) Spirometry for bronchospasm with prolonged evaluation after bronchodilator

118

1.02

0.00

2.0

1.5

—

(3022575) Varicella zoster virus IgG Ab [Units/volume] in Serum

0.00

0.0

1.0

—

1189.56

—

(3020013) Alkaline phosphatase.intestinal [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

1.5

—

8.63

—

(3002148) Methylenedioxymethamphetamine [Presence] in Urine by Screen method

0.00

0.0

1.4

—

(3036428) Adenosine deaminase [Enzymatic activity/volume] in Pleural fluid

0.00

0.0

1.3

—

8.11

—

(3035062) Alkaline phosphatase.liver 1 [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

1.2

—

84.22

—

(3028433) Virus identified in Specimen by Culture

0.00

0.0

1.3

—

(3036185) Alkaline phosphatase.liver 2 [Enzymatic activity/volume] in Serum or Plasma

0.00

0.0

1.2

—

26.78

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

-0.00

0.0

3.0

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.4

—

(3037677) Mycoplasma pneumoniae IgM Ab [Titer] in Cerebral spinal fluid

0.00

-0.00

0.0

1.2

—

(3013727) Leukocytes other/Leukocytes in Blood

0.00

-0.00

0.0

4.3

—

45.14

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.4

—

(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

3.0

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

1.0

—

138.82

—

(3013637) Mi-2 Ab [Presence] in Serum

0.00

-0.00

0.0

1.0

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.4

—

(3028334) Neisseria gonorrhoeae [Presence] in Specimen by Organism specific culture

0.00

-0.00

0.0

1.6

—

(3012565) Volume of 24 hour Urine

0.00

-0.00

0.0

2.2

—

1757.50

—

(42529582) MDA5 Ab [Presence] in Serum by Line blot

0.00

-0.00

0.0

1.0

—

(3007821) Glucose [Moles/volume] in Serum or Plasma --baseline

0.00

-0.00

0.0

1.2

—

9.93

—

(42529598) SUMO-activating enzyme subunit 1 Ab [Presence] in Serum by Line blot

0.00

-0.00

0.0

1.0

—

(3044212) Herpes simplex virus 1+2 IgM Ab [Presence] in Cerebral spinal fluid

0.00

-0.00

0.0

1.2

—

(3004446) Plasmodium sp identified in Blood by Light microscopy

0.00

-0.00

0.0

3.0

—

(40761849) Varicella zoster virus IgG Ab [Units/volume] in Cerebral spinal fluid by Immunoassay

0.00

-0.00

0.0

1.2

—

(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

6.6

—

365.00

—

(42528593) TIF1-gamma Ab [Presence] in Serum by Line blot

0.00

-0.00

0.0

1.0

—

(3036669) Protein S actual/normal in Platelet poor plasma by Coagulation assay

0.00

-0.00

0.0

1.2

—

120.80

—

(42868421) Varicella zoster virus IgM Ab [Presence] in Cerebral spinal fluid by Immunoassay

0.00

-0.00

0.0

1.2

—

(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

3.0

—

(3029023) Hepatitis E virus IgG Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.2

—

(3014271) Vancomycin [Susceptibility]

0.00

-0.00

0.0

2.0

—

(3002222) Hepatitis E virus IgM Ab [Presence] in Serum

0.00

-0.00

0.0

1.2

—

(3025941) Bacteria identified in Stool by Culture

0.96

-0.00

1.3

1.2

—

(3002823) Mycoplasma pneumoniae IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.2

—

(40760109) Toxoplasma gondii IgG Ab avidity [Ratio] in Serum by Immunoassay

0.00

-0.00

0.0

1.0

—

(3035947) Staphylolysin Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.4

—

(3040370) OLANZapine [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

1.4

—

83.60

—

Mortality – FinRegistry

↥

Association

Association between endpoint G6_FEMMEPOP and mortality.

Females

Parameter	HR [95% CI]	p-value
G6_FEMMEPOP	1.318 [0.96, 1.81]	0.09
Birth year	0.994 [0.99, 1.0]	0.183

During the follow-up period (1.1.1998 — 31.12.2019), 52 out of 398 females with G6_FEMMEPOP died.

Males

Parameter	HR [95% CI]	p-value
G6_FEMMEPOP	1.459 [1.03, 2.06]	0.033
Birth year	0.989 [0.98, 1.0]	0.025

During the follow-up period (1.1.1998 — 31.12.2019), 65 out of 344 males with G6_FEMMEPOP died.

Mortality risk

Mortality risk for people of age

years, who have G6_FEMMEPOP.

N-year risk	Females	Males
1	0.125%	0.326%
5	0.826%	1.77%
10	1.935%	4.382%
15	3.731%	8.464%
20	6.789%	14.152%

Relationships between endpoints

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Index endpoint: G6_FEMMEPOP – Lesion of medial popliteal nerve

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Lesion of medial popliteal nerve

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints