Drug-induced myopathy

G6_DRUGMYOP

muscular disease: Acquired, familial, and congenital disorders of skeletal muscle and smooth muscle.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — G72.0# Cause of death: ICD-10 — G72.0# 2 out of 7 registries used, show all original rules.	116
4. Check minimum number of events None	116
5. Include endpoints None	116
6. Filter based on genotype QC (FinnGen only)	103

Control definitions (FinnGen only)

Control exclude: G6_MYONEU

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: G72
Name in latin: Myopathia medicamento provocata

NAME	G6_DRUGMYOP
CONTROL_EXCLUDE	G6_MYONEU
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	G720
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	G720
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Drug-induced myopathy based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1105	444	652
Only index persons	966	397	569
Unadjusted period prevalence (%)
Whole population	0.02	0.01	0.02
Only index persons	0.02	0.01	0.02
Median age at first event (years)
Whole population	64.92	70.20	61.21
Only index persons	64.72	69.67	61.26

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	103	41	62
Unadjusted period prevalence (%)	0.02	0.01	0.03
Median age at first event (years)	62.63	59.54	64.68

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
106: Matched controls
1060

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

G72.0

ICD-10 Finland

Drug-induced myopathy

+∞

152.9

106

G72.8

ICD-10 Finland

Other specified myopathies

+∞

40.2

G72.9

ICD-10 Finland

Myopathy, unspecified

306.4

24.7

Z03.3

ICD-10 Finland

Observation for suspected nervous system disorder

6.3

10.6

N05BA01

ATC

diazepam; systemic, rectal

4.3

9.1

W01

ICD-10 Finland

Fall on same level from slipping, tripping and stumbling

3.4

9.0

246

N17.9

ICD-10 Finland

Acute renal failure, unspecified

8.4

7.5

GD1QA

NOMESCO Finland

Supine thorax X-ray examination

3.3

7.3

149

A06AD11

ATC

lactulose; oral

3.6

7.3

106

N03AG01

ATC

valproic acid; systemic, rectal

7.0

7.1

ZXD05

NOMESCO Finland

Urgent procedure

3.0

6.7

197

G72.1

ICD-10 Finland

Alcoholic myopathy

+∞

6.3

N05CF01

ATC

zopiclone; oral

2.8

6.2

257

AA1AD

NOMESCO Finland

CT of head and brain

2.8

6.2

234

X69

ICD-10 Finland

Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances

13.6

6.2

XF400

NOMESCO Finland

ECG with 12 standard connections

3.1

6.2

129

I20.99

ICD-10 Finland

Angina pectoris, unspecified

4.5

6.1

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3024561) Albumin [Mass/volume] in Serum or Plasma

395

3.01

6.91

5.3

4.4

34.74

35.49

g/l

0.41

378

(3012095) Magnesium [Moles/volume] in Serum or Plasma

169

3.07

6.73

3.3

3.7

0.79

0.82

mmol/l

0.62

160

(3020779) Urea [Moles/volume] in Serum or Plasma

3.36

5.70

9.5

7.3

12.47

9.72

mmol/l

0.71

(3032080) INR in Blood by Coagulation assay

472

2.76

5.56

21.0

16.8

1.27

1.29

inr

0.12

396

(3000991) Gas panel - Venous blood

3.35

5.51

8.0

9.6

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

380

2.52

5.12

2.7

2.1

87.42

93.20

pmol/l

0.50

193

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

3.90

4.81

1.5

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

403

2.39

4.55

2.7

—

estimate

—

(3023368) Bacteria identified in Blood by Culture

273

2.39

4.53

7.3

4.7

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

301

2.34

4.39

3.0

3.3

2.32

2.35

mmol/l

0.57

273

(3006315) Basophils [#/volume] in Blood

465

2.39

4.35

9.6

6.2

0.04

e9/l

0.10

408

(3007853) Bacteria identified in Skin by Aerobe culture

100

2.81

4.27

1.9

1.7

—

(3019198) Lymphocytes [#/volume] in Blood

471

2.33

4.13

9.7

6.3

2.10

1.80

e9/l

0.40

422

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

3.48

4.11

3.7

3.1

24.97

24.57

mmol/l

0.18

(3019309) Folate [Moles/volume] in Red Blood Cells

166

2.43

4.02

2.1

1.7

1335.69

1232.71

nmol/l

0.22

131

(3013115) Eosinophils [#/volume] in Blood

478

2.27

3.90

12.3

6.5

0.20

e9/l

0.06

422

(3013650) Neutrophils [#/volume] in Blood by Automated count

508

2.30

3.88

15.6

10.7

4.88

4.14

e9/l

1.51

443

(3012544) pH of Venous blood

2.76

3.87

6.4

3.8

7.38

7.39

0.26

(3001604) Monocytes [#/volume] in Blood

460

2.24

3.85

9.8

6.2

0.72

0.59

e9/l

1.03

403

(46235355) HIV 1 and 2 tests - Meaningful Use set

127

2.51

3.77

1.7

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

4.78

3.74

1.4

1.3

—

(42870588) Differential panel, method unspecified - Blood

318

2.16

3.69

9.5

5.6

—

(3044640) Blood type and Crossmatch panel - Blood

295

2.15

3.58

2.7

2.5

—

(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot

7.40

3.42

1.0

1.1

—

(3032700) Glomerular basement membrane Ab [Units/volume] in Serum

7.40

3.42

1.1

1.0

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

164

2.26

3.31

2.0

1.9

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

137

2.30

3.17

8.4

6.9

102.56

103.77

mmol/l

0.46

137

(3026008) Bacteria identified in Urine by Culture

266

2.04

3.05

4.3

3.2

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

303

1.99

2.96

3.3

3.4

2336.26

1811.62

ng/l

0.40

255

(3006140) Bilirubin.total [Moles/volume] in Serum or Plasma

489

2.01

2.94

8.0

7.0

13.50

12.22

umol/l

0.16

474

(3027945) Reticulocytes/Erythrocytes in Blood

113

2.32

2.89

2.2

1.79

1.78

0.01

102

(3015736) pH of Urine

369

1.94

2.84

5.0

3.8

6.46

6.18

0.90

215

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

464

1.96

2.82

10.7

7.2

1.19

1.21

mmol/l

0.85

411

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

223

2.01

2.78

2.2

2.5

—

(3021960) Folate [Moles/volume] in Serum or Plasma

266

1.96

2.74

2.0

1.7

18.06

20.48

nmol/l

0.53

212

(40758558) Short blood count panel - Blood

258

1.96

2.72

10.2

6.2

—

(3018418) pH of Serum or Plasma

285

1.93

2.68

5.7

3.7

7.40

7.39

0.18

204

(3019977) pH of Arterial blood

110

2.26

2.65

8.2

8.1

7.40

7.41

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

331

1.89

2.62

4.8

3.3

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

379

1.87

2.54

2.8

2.4

72.18

76.84

nmol/l

0.58

335

(3015399) Transferrin receptor.soluble [Mass/volume] in Serum or Plasma

239

1.92

2.50

2.8

2.0

3.38

2.88

mg/l

0.51

209

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

113

2.19

2.48

1.9

1.8

—

(3027544) Mycobacterium sp identified in Sputum by Organism specific culture

4.33

2.40

2.7

3.3

—

(3013327) Hepatitis A virus IgM Ab [Presence] in Serum

4.33

2.40

1.1

1.0

—

(1616796) Gas panel - Central venous blood

4.33

2.40

1.9

2.9

—

(3019150) Specific gravity of Urine by Refractometry

192

1.95

2.40

6.2

4.4

0.98

1.02

kg/l

0.50

132

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

387

1.81

2.31

5.9

4.3

55.39

52.92

ng/l

0.04

296

(3011960) Natriuretic peptide B [Mass/volume] in Serum or Plasma

2.44

2.30

2.8

3.0

203.13

162.75

ng/l

0.24

(3000764) Benzodiazepines [Presence] in Urine

4.09

2.29

8.7

1.7

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

5.76

2.24

1.2

1.1

—

(3027944) Amphetamines [Presence] in Urine

3.87

2.19

8.7

1.6

—

(3011288) Drugs identified in Urine by Screen method Nominal

4.47

2.18

9.5

1.9

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

119

2.07

2.18

1.9

1.7

—

(3016879) Cocaine [Presence] in Urine

3.67

2.09

8.4

1.6

—

(3028300) Cannabinoids [Presence] in Urine

3.67

2.09

8.6

1.6

—

(3027008) Opiates [Presence] in Urine

3.67

2.09

8.6

1.6

—

(3009261) Glucose [Presence] in Urine by Test strip

464

1.74

2.05

4.9

4.2

0.00

estimate

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

3.91

1.96

4.7

1.5

—

(3028707) Methadone [Presence] in Urine by Screen method

4.71

1.96

6.2

1.5

—

(3010421) pH of Blood

3.33

1.91

2.3

3.8

7.42

7.41

—

(3023183) Ammonium ion [Moles/volume] in Plasma

3.00

1.90

1.9

3.4

26.00

35.35

umol/l

—

(3035350) Ketones [Presence] in Urine by Test strip

461

1.69

1.89

4.9

4.2

0.00

estimate

—

107

(3016650) Hepatitis A virus Ab [Presence] in Serum

3.67

1.86

1.0

1.1

—

(40768797) Stomach Pathology biopsy report

121

1.92

1.74

1.3

—

(3023419) Bacteria identified in Sputum by Culture

3.69

1.63

1.4

2.0

—

(3009508) Creatinine [Moles/volume] in Urine

312

1.64

1.63

5.0

3.4

7.47

7.90

mmol/l

0.23

270

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

156

1.79

1.63

4.9

2.7

4.45

2.40

e6/l

0.32

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.96

1.58

1.9

1.5

—

(3021601) Nitrite [Presence] in Urine by Test strip

450

1.58

1.49

4.5

4.2

0.00

estimate

—

104

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

622

1.63

1.47

4.7

4.3

15.29

14.76

pmol/l

0.75

568

(3004588) Protein electrophoresis panel - Serum or Plasma

2.07

1.45

1.2

2.2

—

(3024891) Influenza virus A+B Ag [Presence] in Specimen

2.70

1.39

1.0

1.3

—

(3019832) Treponema pallidum Ab [Presence] in Serum

2.25

1.38

1.3

1.6

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.16

1.38

1.8

1.7

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

3.03

1.37

1.4

—

(3013290) Carbon dioxide [Partial pressure] in Blood

3.03

1.37

2.6

2.5

4.78

4.77

kpa

—

(3027315) Oxygen [Partial pressure] in Blood

3.03

1.37

2.6

2.5

8.28

7.58

kpa

—

(3042936) Bacteria identified in Isolate by Culture

139

1.74

1.37

3.0

2.0

—

(3013707) Erythrocyte sedimentation rate [Velocity] in Red Blood Cells by Westergren method

650

1.60

1.34

6.2

4.5

14.46

12.76

mm/h

0.46

601

(3000067) Parathyrin.intact [Mass/volume] in Serum or Plasma

2.05

1.34

3.7

3.0

188.42

71.86

ng/l

1.08

(3019060) Gas panel - Arterial blood

2.05

1.34

2.6

3.7

—

(3026493) Urate [Moles/volume] in Serum or Plasma

244

1.58

1.31

3.3

2.6

377.62

349.52

umol/l

0.82

207

(3022313) Gas panel - Capillary blood

2.14

1.30

2.7

2.8

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

2.86

1.30

1.4

1.7

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

2.86

1.30

1.4

1.7

—

(1761868) Lipid panel - Serum or Plasma

320

0.61

1.26

4.9

3.3

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

2.48

1.26

1.2

1.3

—

(3014051) Protein [Presence] in Urine by Test strip

238

1.56

1.24

3.9

3.3

—

0.20

—

(3044290) Cell count panel - Cerebral spinal fluid

2.71

1.23

1.2

1.4

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

2.38

1.20

1.0

1.3

—

(3001334) Neutrophil cytoplasmic Ab [Units/volume] in Serum

2.14

1.18

1.4

1.5

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

2.43

1.14

1.7

2.4

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

105

1.74

1.14

13.6

8.2

—

(46237023) Hepatitis B virus core and surface Ab and surface Ag panel - Serum

2.45

1.10

1.4

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

601

1.49

1.10

4.9

3.3

84.97

54.10

u/l

0.77

567

(3029937) Albumin [Presence] in Urine by Test strip

267

1.46

0.99

4.0

4.1

0.00

estimate

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

110

1.65

0.98

1.6

—

(3020682) Albumin/Creatinine [Ratio] in Urine

315

1.43

0.96

4.9

4.1

7.66

10.31

mg/mmol

0.19

202

(3029379) Protein.monoclonal band 4 [Mass/volume] in Serum or Plasma by Electrophoresis

2.29

0.95

1.3

1.7

0.00

g/l

—

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

171

1.52

0.94

5.0

2.6

0.89

0.79

e6/l

0.11

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.70

0.93

2.0

1.5

—

(3018095) Leukocytes [#/volume] in Urine

356

1.40

0.90

7.0

3.8

37.88

86.94

e6/l

0.65

255

(3021589) Normoblasts [#/volume] in Blood

385

1.40

0.89

15.5

12.9

0.00

e9/l

0.50

318

(3012516) Albumin [Mass/volume] in Urine

303

1.40

0.84

4.2

3.5

39.79

65.70

mg/l

0.72

201

(3009035) Cobalamin (Vitamin B12) [Moles/volume] in Serum or Plasma

194

1.45

0.82

1.7

1.8

570.95

470.68

pmol/l

0.46

167

(3011831) Apolipoprotein B/Apolipoprotein A-I [Percentile]

0.00

0.80

0.0

1.2

—

0.76

—

(3008364) Apolipoprotein A-I [Mass/volume] in Serum or Plasma

0.00

0.80

0.0

1.3

—

1.61

—

(3000475) Leukocytes [#/volume] in Synovial fluid

0.00

0.80

0.0

1.2

—

8550.93

—

(3010156) C reactive protein [Mass/volume] in Serum or Plasma by High sensitivity method

0.00

0.80

0.0

1.3

—

3.86

—

(3019225) pH of Specimen

1.62

0.80

5.1

4.4

7.39

7.33

—

(3014791) Apolipoprotein B [Mass/volume] in Serum or Plasma

0.00

0.79

0.0

1.3

—

0.89

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.73

0.77

4.6

2.8

1.19

1.20

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

1.73

0.77

4.6

2.8

0.71

0.67

—

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

846

1.53

0.76

33.0

17.6

25.77

24.75

mg/l

0.13

708

(3024928) Oxygen saturation in Venous blood

2.14

0.75

3.0

2.4

54.96

61.08

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

1.89

0.69

1.0

1.2

1.09

1.21

g/l

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

1.89

0.69

1.0

1.1

0.25

0.24

g/l

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

1.67

0.68

1.1

1.2

—

(3034770) Mitochondria Ab [Titer] in Serum

1.82

0.67

1.0

1.1

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

343

1.32

0.65

4.3

4.2

0.00

0.02

estimate

—

(3006999) Ribonucleoprotein extractable nuclear Ab [Units/volume] in Serum

1.76

0.64

1.4

—

2.11

—

(3016921) Smith extractable nuclear Ab [Units/volume] in Serum

1.76

0.64

1.2

1.4

—

3.53

—

(3044889) 12 lead EKG panel

600

1.32

0.64

5.1

4.3

—

(3050238) Crystals [Presence] in Synovial fluid by Light microscopy

0.00

0.59

0.0

1.2

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

1.76

0.59

1.0

1.2

—

(36660697) Celiac disease serology panel - Serum

1.59

0.58

1.4

1.2

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

1.61

0.55

1.8

1.7

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.49

0.55

10.4

8.7

27.19

24.92

mmol/l

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

233

0.73

0.55

2.4

3.2

0.92

ug/l

0.00

153

(3002256) Pathology report gross observation

118

1.42

0.54

1.5

1.3

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

764

1.32

0.53

6.5

5.2

1.88

1.97

mu/l

0.34

691

(3008230) Borrelia burgdorferi IgM Ab [Units/volume] in Serum

1.42

0.52

2.2

2.5

—

18.32

—

(3017181) Myelocytes/Leukocytes in Blood

1.45

0.51

3.4

4.9

1.14

0.60

—

(3020891) Body temperature

1.52

0.48

4.7

4.0

37.03

36.94

°c

—

(3030467) Casts [#/volume] in Urine by Automated count

278

1.27

0.48

5.6

3.0

0.34

0.50

e6/l

0.29

201

(3021879) Hepatitis B virus core Ab [Presence] in Serum

1.38

0.42

1.9

1.5

—

(42870365) C reactive protein [Mass/volume] in Blood by High sensitivity method

0.00

0.41

0.0

3.8

—

26.00

—

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

0.00

0.40

0.0

1.3

—

(3021788) Differential panel - Synovial fluid

0.00

0.39

0.0

1.2

—

(3044941) Cell count panel - Synovial fluid

0.00

0.39

0.0

1.1

—

(3009041) Cardiolipin IgG Ab [Units/volume] in Serum by Immunoassay

0.00

0.39

0.0

1.2

—

6.00

—

(40761511) CBC panel - Blood by Automated count

860

1.31

0.39

27.9

15.7

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

209

1.26

0.39

1.5

1.3

2.30

2.16

u/ml

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

1.49

0.37

1.8

2.0

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

0.68

0.34

2.2

1.4

—

(3003694) ABO and Rh group [Type] in Blood

215

1.21

0.30

1.3

1.4

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

816

1.21

0.28

6.3

5.4

6.22

6.01

mmol/l

0.64

744

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

0.69

0.27

1.0

1.7

—

(3021440) Promyelocytes/Leukocytes in Blood

1.29

0.25

3.8

5.1

0.20

0.11

—

(40768804) Tissue Pathology biopsy report

347

1.15

0.23

2.3

2.2

—

(3016251) Hemoglobin.gastrointestinal [Presence] in Stool

1.26

0.23

2.0

2.4

—

(3041096) Erythrocytes [Presence] in Urine by Automated

260

1.16

0.22

3.6

0.00

0.02

estimate

—

(3000850) Epithelial cells [#/volume] in Urine

231

1.17

0.22

4.1

2.6

5.26

5.10

e6/l

0.03

208

(3025941) Bacteria identified in Stool by Culture

1.23

0.22

1.2

—

(3002179) Metamyelocytes/Leukocytes in Blood

1.26

0.22

3.2

4.8

0.80

0.42

—

(40760848) Basement membrane zone BP180 Ab [Units/volume] in Serum by Immunoassay

0.00

0.21

0.0

1.3

—

(37020957) Sapovirus genogroups I+II+IV+V RNA [Presence] in Stool by NAA with probe detection

0.00

0.21

0.0

1.1

—

(42869457) Rotavirus RNA [Identifier] in Stool by NAA with probe detection

0.00

0.21

0.0

1.1

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

0.21

0.0

1.8

—

17.30

—

(37021247) Adenovirus 40+41 DNA [Presence] in Stool by NAA with probe detection

0.00

0.21

0.0

1.1

—

(3025130) Human papilloma virus identified in Specimen

0.00

0.21

0.0

2.2

—

(37020445) Astrovirus RNA [Presence] in Stool by NAA with probe detection

0.00

0.21

0.0

1.1

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

2.7

—

3.03

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.0

—

(3038026) Centromere Ab [Units/volume] in Serum

0.00

0.21

0.0

1.2

—

(3000494) Fungus identified in Specimen by Culture

118

1.21

0.20

1.2

1.5

—

(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum

0.00

0.20

0.0

1.1

—

7.04

—

(3018559) Microscopic observation [Identifier] in Buccal smear by Cyto stain

0.00

0.20

0.0

1.2

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.20

0.18

1.3

—

(40760892) CBC W Ordered Manual Differential panel - Blood

196

1.15

0.18

6.7

5.5

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

1.14

0.17

1.6

1.8

—

(4035726) Immunohistochemistry procedure

1.12

0.15

1.3

—

(3022145) Colonoscopy Study observation

103

1.19

0.14

1.3

1.4

—

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

353

0.91

0.14

1.9

2.0

1.74

1.42

mmol/l

0.64

288

(3007164) IgA [Mass/volume] in Serum or Plasma

181

1.13

0.13

1.5

1.4

2.65

2.45

g/l

0.18

109

(3013512) EKG study

348

1.10

0.13

6.0

3.8

—

(40764999) Glomerular filtration rate [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)/1.73 sq M

820

1.12

0.13

31.2

17.2

77.83

78.20

ml/min/173m2

0.05

760

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

381

0.92

0.12

4.6

5.7

1.85

2.53

ug/l

0.62

339

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

812

1.10

0.11

5.9

4.5

1.44

1.26

mmol/l

1.44

745

(3045424) Erythrocytes [Presence] in Urine

1.14

0.10

1.6

2.5

—

0.00

estimate

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

1.14

0.10

1.0

—

(3013139) Helicobacter pylori Ag [Presence] in Stool

1.14

0.10

1.4

1.2

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

1.04

0.08

2.0

1.7

—

(3048816) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Blood

1.10

0.08

3.0

4.9

1.21

mmol/l

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

122

0.89

0.07

1.4

1.5

—

(3000492) Spirometry study

1.02

0.07

1.8

1.4

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

100

1.11

0.05

5.2

3.9

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

457

1.05

0.05

3.6

2.8

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

300

0.95

0.03

3.5

4.8

24.24

21.87

0.32

159

(3017569) Oxygen content in Arterial blood

0.00

0.0

2.1

—

16.29

—

(21494434) Karyotype in Bone marrow

0.00

0.0

1.0

—

(3013201) Beta-2-Microglobulin [Mass/volume] in Serum or Plasma

0.00

0.0

1.5

—

4.38

—

(40760543) Extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.0

—

(46235128) Lupus anticoagulant aPTT and dRVVT screening panel W Reflex

0.00

0.0

1.1

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

0.0

2.1

—

9.14

—

(40759842) Ribonucleoprotein extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

0.0

1.1

—

(40766800) Mycobacterium tuberculosis stimulated gamma interferon release by CD4+ T-cells [Units/volume] corrected for background in Blood

0.00

0.0

1.6

—

(3037875) Bordetella parapertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.1

—

(3018333) Ribosomal P Ab [Presence] in Serum

0.00

0.0

1.1

—

(42529215) Follitropin [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

1.1

—

38.16

—

(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(4281824) Cell count and differential, peritoneal fluid

0.00

-0.00

0.0

1.0

—

(44806420) Estimation of glomerular filtration rate

0.00

-0.00

0.0

3.3

—

(3034426) Prothrombin time (PT)

0.00

-0.00

0.0

1.2

—

28.20

—

(42528593) TIF1-gamma Ab [Presence] in Serum by Line blot

0.00

-0.00

0.0

1.0

—

(40764127) Haemophilus influenzae DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.2

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

-0.00

0.0

1.0

—

(3002823) Mycoplasma pneumoniae IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.2

—

(3049207) Fetal Trisomy 21 risk [Likelihood] Based on maternal age

0.00

-0.00

0.0

1.8

—

(3048879) Bone marrow aspiration report

0.00

-0.00

0.0

3.8

—

(3012441) Differential panel - Pleural fluid

0.00

-0.00

0.0

1.2

—

(42529582) MDA5 Ab [Presence] in Serum by Line blot

0.00

-0.00

0.0

1.0

—

(3012158) Parainfluenza virus 2 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.5

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3000108) Respiratory syncytial virus B RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.8

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

-0.00

0.0

2.2

—

(44816844) Macroprolactin [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

275.40

—

(40761536) Microorganisms panel - Urine sediment

1.02

-0.00

3.3

4.0

—

(3013637) Mi-2 Ab [Presence] in Serum

0.00

-0.00

0.0

1.0

—

(3006262) Parainfluenza virus 3 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.5

—

(3025577) Chromium [Mass/volume] in Blood

0.00

-0.00

0.0

3.4

—

3.22

—

(42868421) Varicella zoster virus IgM Ab [Presence] in Cerebral spinal fluid by Immunoassay

0.00

-0.00

0.0

1.3

—

(3030136) 5-Hydroxyindoleacetate [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

4.2

—

53.80

—

(42529598) SUMO-activating enzyme subunit 1 Ab [Presence] in Serum by Line blot

0.00

-0.00

0.0

1.0

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

-0.00

0.0

1.4

—

(3025634) Parainfluenza virus 1 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.5

—

(4010399) Spirometry for bronchospasm with prolonged evaluation after bronchodilator

0.90

-0.00

1.7

1.3

—

(3028433) Virus identified in Specimen by Culture

0.00

-0.00

0.0

1.8

—

(3019897) Erythrocyte [DistWidth] in Red Blood Cells by Automated count

0.00

-0.00

0.0

1.8

—

12.80

—

(3035947) Staphylolysin Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.0

—

(3038297) Parainfluenza virus 4 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.5

—

(3044212) Herpes simplex virus 1+2 IgM Ab [Presence] in Cerebral spinal fluid

0.00

-0.00

0.0

1.5

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

-0.00

0.0

1.1

—

(3045142) Bone marrow Pathology biopsy report

0.00

-0.00

0.0

1.2

—

(3037677) Mycoplasma pneumoniae IgM Ab [Titer] in Cerebral spinal fluid

0.00

-0.00

0.0

1.2

—

(3019420) Tryptase [Mass/volume] in Serum or Plasma

0.00

-0.00

0.0

1.2

—

7.02

—

(21493195) Respiratory pathogens DNA and RNA tested for in Respiratory system specimen by NAA with probe detection

0.00

-0.00

0.0

2.5

—

(3005156) Respiratory syncytial virus A RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

2.8

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

-0.00

0.0

1.2

—

(40761849) Varicella zoster virus IgG Ab [Units/volume] in Cerebral spinal fluid by Immunoassay

0.00

-0.00

0.0

1.3

—

Mortality – FinRegistry

↥

Association

Association between endpoint G6_DRUGMYOP and mortality.

Females

Parameter	HR [95% CI]	p-value
G6_DRUGMYOP	2.524 [1.94, 3.28]	< 0.001
Birth year	0.998 [0.99, 1.01]	0.681

During the follow-up period (1.1.1998 — 31.12.2019), 206 out of 406 females with G6_DRUGMYOP died.

Males

Parameter	HR [95% CI]	p-value
G6_DRUGMYOP	3.526 [2.43, 5.11]	< 0.001
Birth year	0.984 [0.97, 0.99]	0.001

During the follow-up period (1.1.1998 — 31.12.2019), 311 out of 603 males with G6_DRUGMYOP died.

Mortality risk

Mortality risk for people of age

years, who have G6_DRUGMYOP.

N-year risk	Females	Males
1	0.338%	0.656%
5	1.617%	3.793%
10	4.124%	9.144%
15	7.844%	16.717%
20	13.534%	27.041%

Relationships between endpoints

↥

Index endpoint: G6_DRUGMYOP – Drug-induced myopathy

GWS hits: 1

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Drug-induced myopathy

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints