brain disease: A disease affecting the brain or part of the brain.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
412 |
4. Check minimum number of eventsNone |
412 |
5. Include endpointsNone |
412 |
6. Filter based on genotype QC (FinnGen only) |
365 |
Control definitions (FinnGen only)
- Control exclude
- G6_OTHNEU
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Disorders of brain, other and unspecified
based on the number of shared cases.
Similar with more cases:
- Other neurological diseases
- Neurological diseases
- Neurological diseases, wide definition
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4808 | 2024 | 2697 |
| Only index persons | 2930 | 1376 | 1554 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.07 | 0.06 | 0.08 |
| Only index persons | 0.06 | 0.05 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 48.81 | 47.92 | 49.20 |
| Only index persons | 41.61 | 43.17 | 40.23 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 365 | 160 | 205 |
| Unadjusted period prevalence (%) | 0.08 | 0.06 | 0.09 |
| Median age at first event (years) | 48.71 | 43.63 | 52.67 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 374
- Matched controls
- 3740
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G93.99
ICD-10 Finland
Disorder of brain, unspecified
+∞
79.0
73
*
G93.8
ICD-10 Finland
Other specified disorders of brain
+∞
77.9
72
*
34799
ICD-8 Finland
Other disease of brain, Other and unspecified
+∞
67.8
63
*
34798
ICD-8 Finland
Other disease of brain, Alii definiti
+∞
62.3
58
*
G93.90
ICD-10 Finland
Brain death
+∞
58.9
55
*
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
9.9
55.4
70
85
G40.9
ICD-10 Finland
Epilepsy, unspecified
10.2
36.4
43
47
N03AX14
ATC
levetiracetam; systemic
12.3
35.0
36
32
YKA02
NOMESCO Finland
Excision of kidneys from cadaver donor
+∞
30.6
29
*
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
11.2
27.5
30
29
YJA10
NOMESCO Finland
Excision of liver from cadaver donor
+∞
23.2
22
*
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
29.5
22.6
30
11
AA1AD
NOMESCO Finland
CT of head and brain
3.0
22.4
144
644
3489X
ICD-9 Finland
Other conditions of brain, Unspecified condition of brain
+∞
22.1
21
*
3488X
ICD-9 Finland
Other conditions of brain
+∞
20.0
19
*
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
7.4
18.1
27
39
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
4.1
17.9
54
148
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
4.1
17.5
52
141
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.9
16.6
95
390
G93.9
ICD-10 Finland
Disorder of brain, unspecified
+∞
15.7
15
*
N03AF02
ATC
oxcarbazepine; oral
7.1
15.5
24
36
TAB00
NOMESCO Finland
Lumbar puncture
4.9
14.0
32
70
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
3.4
14.0
54
175
XA800
NOMESCO Finland
Neuropsychological investigation
5.0
13.8
31
67
R56.8
ICD-10 Finland
Other and unspecified convulsions
4.6
13.7
34
80
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
13.5
13.6
23
18
N03AF01
ATC
carbamazepine; oral, rectal
4.1
13.2
38
100
YFA50
NOMESCO Finland
Excision of heart for preparation of homograft
+∞
12.6
12
*
I46.0
ICD-10 Finland
Cardiac arrest with successful resuscitation
13.1
11.8
20
16
R41.0
ICD-10 Finland
Disorientation, unspecified
5.5
11.7
23
44
G93.4
ICD-10 Finland
Encephalopathy, unspecified
123.7
11.5
12
*
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
10.1
11.4
22
23
R42
ICD-10 Finland
Dizziness and giddiness
2.3
11.2
102
517
G40.20
ICD-10 Finland
Complex partial seizures with only alteration of consciousness
18.5
10.8
16
9
G45.1
ICD-10 Finland
Carotid artery syndrome (hemispheric)
+∞
10.5
10
*
S06.5
ICD-10 Finland
Traumatic subdural haemorrhage
4.6
9.9
24
55
AA5BD
NOMESCO Finland
CT of cerebral ischaemia
10.4
9.6
18
18
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.6
9.6
33
99
N05BA01
ATC
diazepam; systemic, rectal
2.5
9.5
66
294
I61.0
ICD-10 Finland
Intracerebral haemorrhage in hemisphere, subcortical
8.4
9.5
20
25
B01AC30
ATC
platelet aggregation inhibitors excl. heparin - combinations
4.0
9.4
27
71
183
Kela drug reimbursment
Lamotrigin and topiramate
16.1
9.1
14
9
H53.2
ICD-10 Finland
Diplopia
4.9
8.9
20
43
WX730
NOMESCO Finland
Conventional respirator
16.8
8.6
13
8
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
4.1
8.6
24
62
N03AG01
ATC
valproic acid; systemic, rectal
3.3
8.4
32
102
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
3.0
8.4
38
135
G40.12
ICD-10 Finland
Simple partial seizures with secondary generalization
14.9
8.3
13
9
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
4.5
8.2
20
46
WX892
NOMESCO Finland
Monitored bed care
3.0
8.1
38
138
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.1
7.5
80
426
G45.0
ICD-10 Finland
Vertebro-basilar artery syndrome
81.6
7.4
8
*
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
+∞
7.3
7
*
A28
ICPC
Limited function/disability NOS
2.1
7.2
79
424
N06AB04
ATC
citalopram; systemic
2.0
7.0
84
467
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
3.2
6.9
28
93
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
2.4
6.8
47
208
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.8
6.8
34
128
78020
ICD-8 Finland
Certain symptoms referable to nervous system and special senses, Convulsions
17.1
6.8
10
6
A06AD11
ATC
lactulose; oral
2.1
6.6
68
356
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
6.4
6.5
16
26
N05AB03
ATC
perphenazine; systemic, rectal
3.9
6.4
19
51
N03AX18
ATC
lacosamide; systemic
14.6
6.4
10
7
N03AX09
ATC
lamotrigine; oral
3.5
6.4
22
66
K91
ICPC
Cerebrovascular disease
11.3
6.3
11
10
L04AD02
ATC
tacrolimus; systemic
11.3
6.3
11
10
XF400
NOMESCO Finland
ECG with 12 standard connections
2.1
6.3
68
362
G91.9
ICD-10 Finland
Hydrocephalus, unspecified
+∞
6.3
6
*
G93.1
ICD-10 Finland
Anoxic brain damage, not elsewhere classified
+∞
6.3
6
*
G93.0
ICD-10 Finland
Cerebral cysts
+∞
6.3
6
*
N05AH03
ATC
olanzapine; systemic
2.8
6.2
31
117
SPAT1215
SPAT
Assessment of need for medical rehabilitation
3.6
6.1
20
58
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
33
60
5.94
17.76
2.1
1.2
28.62
5.24
e6/l
1.03
26
46
33
62
5.74
17.16
2.1
1.3
831.56
298.50
e6/l
0.38
27
48
83
367
2.62
12.31
10.1
8.8
1.25
1.01
mmol/l
0.21
70
302
19
19
10.47
10.13
2.7
1.2
—
—
—
0
0
84
426
2.25
9.01
11.3
6.9
105.32
104.07
mmol/l
1.26
84
426
198
1452
1.77
6.83
21.5
14.2
1.31
1.27
inr
0.35
167
1189
14
19
7.61
6.47
1.2
1.0
—
—
—
0
0
190
1396
1.73
6.35
12.8
6.5
1.19
1.21
mmol/l
2.35
178
1286
16
28
5.92
6.21
1.1
1.0
—
—
—
0
0
204
1543
1.71
6.02
11.1
7.3
1.20
1.21
mmol/l
0.72
174
1340
16
32
5.18
5.63
1.0
1.0
—
—
—
0
0
13
20
6.69
5.60
1.6
1.2
0.55
0.50
ratio
—
8
10
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
11
13
8.68
5.59
1.2
1.2
—
—
—
0
0
229
1818
1.67
5.37
8.6
5.0
6.97
6.75
mmol/l
0.80
222
1718
16
34
4.87
5.36
1.0
1.0
—
—
—
0
0
5
0
+∞
5.22
3.8
0.0
—
—
—
0
0
141
1004
1.65
4.98
2.9
2.5
57.51
61.74
u/l
0.35
132
936
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
23
85
2.82
4.77
4.4
2.6
0.27
0.38
iu/ml
1.08
18
46
10
14
7.31
4.68
3.5
3.1
23.30
10.91
mu/l
—
10
14
178
1360
1.59
4.62
8.1
4.9
34.23
35.50
g/l
2.12
168
1283
9
11
8.35
4.58
1.1
1.1
—
—
—
0
0
84
532
1.75
4.53
2.0
1.7
1186.31
1148.43
nmol/l
0.12
70
408
35
166
2.22
4.35
1.8
1.4
—
—
—
0
0
106
734
1.62
4.05
3.5
2.4
—
—
—
0
0
7
8
8.89
3.79
1.7
1.1
—
—
—
0
0
88
599
1.61
3.57
4.2
3.7
964.66
433.71
ng/l
0.26
71
485
53
318
1.78
3.42
8.0
3.6
2.21
1.68
mmol/l
0.36
48
261
34
176
2.02
3.42
1.1
1.3
—
47.66
—
0
12
13
42
3.17
3.40
1.2
1.1
—
—
—
0
0
28
135
2.16
3.37
2.8
1.8
1.52
1.44
g/l
0.13
23
126
76
507
1.63
3.33
4.9
3.1
1.84
2.11
e6/l
0.17
44
254
36
195
1.94
3.20
2.0
2.5
—
13.43
—
0
14
119
889
1.50
3.15
4.5
3.2
0.30
0.42
e6/l
0.48
98
659
21
93
2.33
3.09
1.6
1.3
—
—
—
0
0
6
8
7.60
3.06
12.2
1.4
86.50
104.38
%
—
6
8
7
12
5.92
3.03
1.1
1.1
—
—
—
0
0
7
12
5.92
3.03
4.6
1.9
0.60
0.62
mmol/l
—
7
12
79
544
1.57
3.03
2.0
1.9
—
—
—
0
0
15
57
2.70
3.00
1.3
1.3
—
—
—
0
0
15
57
2.70
3.00
1.3
1.3
—
—
—
0
0
12
299
0.38
2.92
2.1
2.1
3.80
3.46
ratio
—
7
240
200
1669
1.43
2.90
9.5
7.0
11.57
11.60
umol/l
0.01
193
1588
133
1031
1.45
2.88
4.8
3.3
16.63
135.21
e6/l
1.19
110
796
109
814
1.48
2.86
2.7
2.1
3.28
3.05
mg/l
0.35
104
701
60
392
1.63
2.85
1.9
1.8
—
—
—
0
0
30
159
1.96
2.85
2.5
3.8
3.96
4.46
pmol/l
1.69
25
142
95
691
1.50
2.83
2.5
1.7
2.32
1.37
mg/l
0.70
80
546
19
85
2.30
2.75
1.9
1.8
—
—
—
0
0
55
356
1.64
2.71
6.2
4.6
290.44
241.40
u/l
0.40
50
340
257
2845
0.69
2.69
5.5
5.0
1.42
1.45
mmol/l
0.51
234
2648
8
19
4.28
2.69
2.4
2.4
—
—
—
0
0
9
24
3.82
2.69
1.6
1.4
—
—
—
0
0
5
7
7.22
2.55
1.0
1.1
—
—
—
0
0
14
57
2.51
2.48
2.4
1.5
76.30
166.96
au/ml
—
6
15
8
21
3.87
2.47
1.1
1.0
3433.62
263.54
ng/l
—
8
13
8
21
3.87
2.47
1.1
1.0
713.38
614.23
ng/l
—
8
13
61
416
1.56
2.43
1.9
1.7
—
—
—
0
0
6
12
5.06
2.41
1.2
1.2
—
—
—
0
0
10
34
2.99
2.30
1.8
1.9
—
—
—
0
0
149
1217
1.37
2.29
4.1
3.7
54.07
84.47
ng/l
0.27
118
870
12
47
2.60
2.29
1.3
1.3
2.00
1.39
u/ml
—
6
18
8
23
3.53
2.28
1.9
2.3
—
—
—
0
0
38
234
1.69
2.28
8.7
4.0
94.98
90.18
ng/l
0.11
33
204
132
1059
1.38
2.26
5.3
3.6
33.56
35.35
u/l
0.24
124
1006
32
188
1.77
2.25
10.1
3.9
23.38
24.02
mmol/l
0.43
32
188
267
2911
0.71
2.25
6.3
5.8
2.59
2.69
mmol/l
1.06
246
2716
203
1747
1.35
2.21
12.2
10.1
4.47
4.17
e9/l
0.83
186
1523
254
2787
0.72
2.17
23.7
15.8
83.84
80.03
ml/min/173m2
2.14
232
2579
100
1264
0.71
2.17
1.8
1.9
1.51
1.37
mmol/l
0.80
84
1062
7
19
3.73
2.16
1.3
1.7
—
—
—
0
0
7
19
3.73
2.16
1.9
1.8
—
—
—
0
0
7
19
3.73
2.16
1.9
1.8
—
—
—
0
0
44
287
1.60
2.12
1.7
2.5
30.61
34.14
u/l
0.44
38
235
47
312
1.58
2.11
3.4
3.5
—
—
—
0
0
168
1414
1.34
2.08
4.0
2.8
—
—
estimate
—
0
0
5
10
5.05
2.07
1.0
1.0
—
—
—
0
0
263
2862
0.73
2.05
5.5
5.1
4.44
4.60
mmol/l
1.81
241
2682
6
15
4.05
2.04
1.8
1.4
—
—
—
0
0
6
15
4.05
2.04
1.8
1.4
—
—
—
0
0
32
195
1.70
2.01
1.5
1.8
—
—
—
0
0
75
556
1.44
2.00
4.7
2.9
0.55
0.92
e6/l
1.64
44
301
10
39
2.61
1.95
1.8
1.8
—
—
—
0
0
298
3171
0.70
1.92
38.5
24.9
130.68
135.45
g/l
5.90
293
3140
298
3170
0.71
1.91
38.1
24.7
4.36
4.50
e12/l
3.99
287
3101
298
3170
0.71
1.91
38.9
25.2
39.04
40.32
%
3.65
292
3136
36
230
1.63
1.90
1.9
1.5
—
—
—
0
0
55
388
1.49
1.89
7.3
2.8
8.15
7.66
umol/l
0.08
48
347
298
3168
0.71
1.87
38.4
24.8
245.00
245.83
e9/l
0.06
289
3112
298
3168
0.71
1.87
38.0
24.7
91.09
91.19
fl
0.11
293
3138
250
2725
0.75
1.81
4.9
4.3
1.31
1.29
mmol/l
0.21
228
2523
19
103
1.89
1.75
1.6
1.5
—
—
—
0
0
9
36
2.54
1.75
1.1
1.1
—
—
—
0
0
8
30
2.70
1.73
2.1
1.6
—
—
—
0
0
8
30
2.70
1.73
2.1
1.6
—
—
—
0
0
8
30
2.70
1.73
2.1
1.6
—
—
—
0
0
14
68
2.10
1.72
1.7
1.7
—
—
—
0
0
5
13
3.88
1.72
1.4
1.4
—
—
—
0
0
5
13
3.88
1.72
1.4
1.4
—
—
—
0
0
255
2761
0.76
1.66
7.5
6.5
40.27
39.44
mmol/mol
0.65
236
2598
11
49
2.28
1.65
1.1
1.5
—
—
—
0
0
28
177
1.63
1.57
1.3
1.2
47.13
137.78
u/ml
—
6
73
92
1128
0.76
1.54
4.4
5.3
1.82
2.57
ug/l
1.15
82
1007
16
87
1.88
1.48
1.4
1.3
296.27
330.11
ug/g
0.41
11
49
20
117
1.75
1.48
2.1
2.2
—
—
—
0
0
19
110
1.77
1.46
1.9
2.0
—
—
—
0
0
5
16
3.15
1.44
1.2
2.2
833.80
843.19
u/ml
—
5
16
16
89
1.83
1.39
4.8
3.2
2.56
2.35
index
—
9
57
290
3066
0.76
1.38
17.6
12.3
25.85
26.60
u/l
0.31
280
2983
6
23
2.63
1.37
1.7
1.4
—
—
—
0
0
29
193
1.54
1.34
5.2
3.6
1.99
2.05
mmol/l
0.03
20
142
17
98
1.77
1.33
1.6
1.5
—
—
—
0
0
15
83
1.84
1.33
1.7
1.4
—
—
—
0
0
15
83
1.84
1.33
1.2
1.5
—
—
—
0
0
9
43
2.12
1.31
1.6
1.4
—
—
—
0
0
12
62
1.97
1.29
1.4
1.2
368.75
246.91
u/ml
0.71
12
34
14
77
1.85
1.27
1.1
1.2
—
31.48
—
0
9
16
92
1.77
1.27
1.3
2.5
1.27
2.44
ratio
0.75
11
47
8
36
2.25
1.25
1.0
1.1
—
—
—
0
0
103
864
1.27
1.21
5.0
3.9
0.00
0.01
estimate
0.74
32
298
16
94
1.73
1.19
1.6
1.3
—
—
—
0
0
16
257
0.61
1.16
3.8
1.7
—
—
—
0
0
12
65
1.87
1.14
1.4
1.2
—
—
—
0
0
18
280
0.62
1.14
3.6
1.9
—
—
—
0
0
7
30
2.36
1.13
1.0
1.1
—
—
—
0
0
8
40
2.02
1.12
1.1
1.3
0.79
0.53
nmol/l
—
8
35
43
322
1.38
1.12
9.7
6.6
—
—
—
0
0
7
31
2.28
1.11
1.0
1.2
—
—
—
0
0
7
31
2.28
1.11
1.0
1.2
—
—
—
0
0
36
262
1.41
1.11
1.4
2.4
64.08
66.95
g/l
1.03
29
239
14
82
1.73
1.06
1.1
1.1
—
—
—
0
0
7
33
2.14
1.06
1.0
1.5
—
—
—
0
0
7
33
2.14
1.06
1.0
1.2
—
—
—
0
0
5
22
2.29
1.03
1.0
1.4
—
—
—
0
0
7
34
2.08
1.03
1.7
1.9
505.00
1583.82
mg
—
7
34
14
83
1.71
1.03
1.1
1.1
—
—
—
0
0
10
53
1.91
1.02
1.1
1.5
—
—
—
0
0
105
900
1.23
1.01
2.0
1.7
18.31
20.15
nmol/l
0.71
91
759
14
84
1.69
0.99
1.1
1.2
—
—
—
0
0
7
37
1.91
0.94
2.3
1.5
—
—
—
0
0
54
667
0.78
0.94
3.0
3.2
0.98
0.79
ug/l
0.20
42
425
8
43
1.88
0.88
1.4
1.6
—
—
—
0
0
6
30
2.02
0.87
1.0
1.0
—
—
—
0
0
6
30
2.02
0.87
1.0
1.2
—
—
—
0
0
298
3100
0.81
0.86
30.9
21.1
76.51
80.16
umol/l
1.02
293
3059
76
892
0.81
0.85
4.4
4.6
22.33
22.09
%
0.04
32
434
73
614
1.23
0.84
1.9
1.8
450.55
22034315.73
pmol/l
0.50
62
531
72
607
1.23
0.81
3.4
2.8
2.44
2.45
mmol/l
0.38
64
546
5
97
0.51
0.79
1.2
1.2
1.34
1.54
g/l
—
5
97
28
209
1.37
0.78
4.1
2.9
122.93
128.08
g/l
0.56
28
203
25
183
1.39
0.78
3.8
2.7
1.04
1.33
%
1.24
25
183
6
34
1.78
0.76
1.2
1.1
—
—
—
0
0
19
133
1.45
0.75
1.3
1.4
—
—
—
0
0
5
26
1.94
0.71
8.6
2.5
14.16
6.65
umol/l
—
5
20
146
1331
1.16
0.69
3.5
2.5
70.45
77.67
nmol/l
3.16
134
1200
118
1060
1.17
0.67
3.8
3.5
2.34
2.35
mmol/l
0.25
107
960
24
180
1.36
0.67
4.0
2.6
0.63
0.62
%
0.07
24
180
148
1356
1.15
0.65
2.7
2.1
94.55
95.11
pmol/l
0.05
89
709
40
325
1.26
0.64
2.4
1.8
1.58
1.53
%
0.18
33
291
244
2323
1.14
0.59
11.4
8.6
76.82
79.39
u/l
0.54
233
2197
10
64
1.58
0.59
2.1
1.4
—
—
—
0
0
117
1062
1.15
0.58
4.3
3.4
6.73
7.73
mmol/l
1.61
99
898
6
35
1.73
0.58
1.7
1.2
—
—
—
0
0
6
36
1.68
0.57
2.5
1.5
—
—
—
0
0
6
37
1.63
0.56
2.5
1.5
—
—
—
0
0
30
242
1.26
0.53
2.9
2.8
72.85
62.97
ml/min/173m2
0.84
13
105
235
2453
0.89
0.51
30.3
20.3
13.93
13.68
%
1.58
230
2424
31
375
0.81
0.49
5.8
4.8
31.39
31.45
%
0.01
23
255
16
119
1.36
0.49
12.9
3.3
1.23
1.56
mg/l
1.36
16
106
11
76
1.46
0.48
1.2
1.3
—
—
—
0
0
165
1750
0.90
0.46
2.8
3.1
—
—
—
0
0
10
69
1.46
0.44
1.3
1.5
—
—
—
0
0
151
1417
1.11
0.43
3.9
3.0
121.95
142.41
ug/l
0.55
142
1333
111
1024
1.12
0.43
4.8
4.1
23.51
9.54
mg/mmol
0.75
74
656
0
15
0.00
0.41
0.0
1.2
—
11.73
—
0
15
8
59
1.36
0.41
1.4
1.6
—
—
—
0
0
260
2683
0.90
0.40
6.5
5.1
2.05
1.90
mu/l
0.86
241
2462
10
71
1.42
0.39
1.4
1.3
—
—
—
0
0
17
136
1.26
0.34
2.1
1.6
0.35
0.37
mg/l
—
6
59
6
45
1.34
0.34
2.0
2.8
105.67
105.38
mmol/l
—
6
45
6
45
1.34
0.34
2.0
2.8
1.21
1.19
mmol/l
—
6
45
209
2015
1.08
0.31
6.1
3.3
58.78
48.61
u/l
0.36
195
1914
26
301
0.85
0.29
2.0
2.2
14.00
13.44
nmol/l
0.07
18
284
45
497
0.89
0.26
1.7
1.5
—
—
—
0
0
10
77
1.31
0.26
1.7
1.2
—
—
—
0
0
5
71
0.70
0.26
1.6
1.4
—
—
—
0
0
16
132
1.22
0.26
2.7
2.1
—
—
—
0
0
104
982
1.08
0.25
2.7
3.3
1519.42
1544.72
ng/l
0.02
90
841
9
73
1.24
0.25
1.0
1.5
—
—
—
0
0
275
2807
0.92
0.25
5.0
5.1
6.06
5.99
mmol/l
0.26
254
2586
6
84
0.71
0.24
1.2
1.1
—
10.97
—
0
10
27
237
1.15
0.24
1.4
1.4
—
—
—
0
0
5
39
1.29
0.23
5.0
4.9
—
—
—
0
0
167
1612
1.07
0.22
5.3
3.8
0.00
4.93
estimate
0.50
39
330
0
11
0.00
0.21
0.0
1.2
—
104.00
—
0
11
0
10
0.00
0.21
0.0
1.2
—
290.20
—
0
5
0
12
0.00
0.21
0.0
1.7
—
40.63
—
0
12
5
43
1.16
0.21
1.6
1.2
—
—
—
0
0
165
1597
1.06
0.20
5.3
3.8
0.00
0.00
estimate
-0.00
36
326
295
2993
0.93
0.19
30.5
19.0
139.52
139.73
mmol/l
0.57
290
2937
6
52
1.16
0.19
1.5
1.4
—
—
—
0
0
6
52
1.16
0.19
1.2
3.4
5.38
8.58
pmol/l
—
6
52
84
884
0.94
0.18
3.7
3.3
0.00
0.01
estimate
0.80
27
254
76
721
1.07
0.17
6.5
3.8
1.02
1.02
kg/l
1.20
54
486
296
2998
0.94
0.16
29.4
19.1
3.94
3.99
mmol/l
1.84
291
2935
167
1628
1.05
0.14
5.3
3.8
0.00
0.01
estimate
0.50
36
302
7
88
0.79
0.14
1.3
1.5
—
—
—
0
0
43
402
1.08
0.14
1.6
1.5
—
—
—
0
0
8
97
0.82
0.14
1.5
1.4
—
—
—
0
0
290
2933
0.95
0.13
25.6
16.1
30.05
24.29
mg/l
1.61
254
2428
9
109
0.82
0.13
3.8
2.0
—
—
—
0
0
9
110
0.81
0.13
1.8
1.5
27.46
24.54
iu/l
—
9
86
10
85
1.18
0.12
1.9
1.4
—
—
—
0
0
47
496
0.94
0.12
1.3
1.3
3.43
13.51
u/ml
1.81
13
192
10
87
1.15
0.09
1.0
1.3
—
—
—
0
0
75
725
1.04
0.09
1.4
1.3
1.02
1.72
u/ml
0.87
21
197
6
57
1.05
0.08
3.7
1.3
140.27
20.71
u/l
—
6
51
52
539
0.96
0.07
1.2
1.3
27.11
32.50
iu/ml
0.27
18
170
224
2216
1.03
0.07
5.3
4.1
14.73
14.79
pmol/l
0.13
205
2033
76
780
0.97
0.07
3.9
2.8
310.88
353.62
umol/l
2.99
67
682
121
1231
0.97
0.06
5.4
3.7
0.00
0.04
estimate
1.23
28
274
13
121
1.08
0.04
2.2
2.7
—
—
—
0
0
219
2204
0.98
0.03
5.5
4.3
13.06
12.12
mm/h
0.37
205
2054
10
102
0.98
0.00
1.4
1.6
—
—
—
0
0
33
331
1.00
0.00
2.9
4.7
34.23
46.75
ug/l
0.12
26
275
16
157
1.02
0.00
1.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
4.8
—
161.00
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
8.0
—
6.02
—
0
5
6
66
0.91
-0.00
1.3
1.4
0.80
0.83
nmol/l
—
6
55
0
5
0.00
-0.00
0.0
9.2
—
9.48
—
0
5
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
6.9
—
5.86
—
0
8
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
9
99
0.91
-0.00
2.4
1.2
0.87
0.87
g/l
—
9
99
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint G6_DISBROTHUNS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_DISBROTHUNS | 3.99 [2.68, 5.94] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.697 |
During the follow-up period (1.1.1998 — 31.12.2019), 173 out of 487 females with G6_DISBROTHUNS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_DISBROTHUNS | 4.946 [3.66, 6.68] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.041 |
During the follow-up period (1.1.1998 — 31.12.2019), 227 out of 545 males with G6_DISBROTHUNS died.
Mortality risk
Mortality risk for people of age
years, who have G6_DISBROTHUNS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.44% | 0.838% |
| 5 | 2.171% | 5.642% |
| 10 | 6.164% | 14.249% |
| 15 | 11.626% | 26.237% |
| 20 | 20.3% | 41.219% |
Relationships between endpoints
↥Index endpoint: G6_DISBROTHUNS – Disorders of brain, other and unspecified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data