No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
593 |
4. Check minimum number of eventsNone |
593 |
5. Include endpointsNone |
593 |
6. Filter based on genotype QC (FinnGen only) |
522 |
Control definitions (FinnGen only)
- Control exclude
- G6_OTHNEU
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- G93
- Name in latin
- Laesio anoxica cerebri non alibi classificata
Similar endpoints
↥List of similar endpoints to
Anoxic brain damage
based on the number of shared cases.
Similar with more cases:
- Other neurological diseases
- Neurological diseases
- Neurological diseases, wide definition
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 7504 | 2213 | 5132 |
| Only index persons | 4082 | 1219 | 2863 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.12 | 0.06 | 0.14 |
| Only index persons | 0.09 | 0.04 | 0.11 |
| Median age at first event (years) | |||
| Whole population | 60.56 | 61.03 | 60.15 |
| Only index persons | 60.34 | 60.12 | 60.43 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 522 | 138 | 384 |
| Unadjusted period prevalence (%) | 0.14 | 0.05 | 0.18 |
| Median age at first event (years) | 63.23 | 59.39 | 64.61 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 535
- Matched controls
- 5350
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G93.1
ICD-10 Finland
Anoxic brain damage, not elsewhere classified
+∞
307.7
522
*
I46.0
ICD-10 Finland
Cardiac arrest with successful resuscitation
220.8
307.7
317
35
I49.0
ICD-10 Finland
Ventricular fibrillation and flutter
40.8
138.7
86
25
WX730
NOMESCO Finland
Conventional respirator
26.7
101.7
72
31
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
5.5
81.8
236
670
WX872
NOMESCO Finland
Intensive care
6.7
53.0
93
162
GBB00
NOMESCO Finland
Tracheostomy
17.5
43.0
36
22
XA800
NOMESCO Finland
Neuropsychological investigation
7.2
37.4
59
91
AA1AD
NOMESCO Finland
CT of head and brain
3.1
35.6
228
1025
I47.2
ICD-10 Finland
Ventricular tachycardia
8.0
33.2
47
64
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
8.9
32.5
42
51
WX930
NOMESCO Finland
Thepapeutic hypothermia
74.6
31.3
35
5
N03AG01
ATC
valproic acid; systemic, rectal
4.9
26.2
61
136
I25.2
ICD-10 Finland
Old myocardial infarction
3.7
25.5
93
290
A98
ICPC
Health maint/preventive medicine
0.4
24.8
339
4399
I25.1
ICD-10 Finland
Atherosclerotic heart disease
2.5
21.5
205
1074
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
4.5
21.2
54
129
FPG30
NOMESCO Finland
Implantation of cardioverter-defibrillator with ventricular electrode
19.8
20.2
30
16
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
3.4
19.9
78
254
WX900
NOMESCO Finland
Resuscitation
47.9
19.3
23
5
N03AX14
ATC
levetiracetam; systemic
6.1
19.1
34
59
I46.9
ICD-10 Finland
Cardiac arrest, unspecified
20.2
18.4
27
14
Z2445
NOMESCO Finland
Psychologist
5.1
18.1
39
81
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
2.3
17.5
182
976
T36
ICD-10 Finland
Poisoning by systemic antibiotics
4.9
16.6
38
83
AN1
HP
Coronary angiography
2.7
16.0
101
428
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
3.6
15.8
54
160
3481A
ICD-9 Finland
Other conditions of brain, Anoxic brain damage
+∞
15.7
15
*
Z02.4
ICD-10 Finland
Examination for driving licence
0.3
15.6
47
1313
C01BD01
ATC
amiodarone; systemic
4.9
15.1
34
73
201
Kela drug reimbursment
Chronic cardiac insufficiency
3.2
15.0
65
224
206
Kela drug reimbursment
Chronic coronary artery disease and dyslipidaemia associated with chronic coronary artery disease
2.2
14.9
163
883
X44
ICD-10 Finland
Accidental poisoning by and exposure to other and unspecified drugs, medicaments and biological substances
13.9
14.3
24
18
Z95.0
ICD-10 Finland
Presence of electronic cardiac devices
3.2
14.2
60
203
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.1
14.1
62
215
Z45.0
ICD-10 Finland
Adjustment and management of cardiac devices
3.7
14.1
47
137
ZXD00
NOMESCO Finland
Emergency procedure
4.9
13.5
30
64
I42.0
ICD-10 Finland
Dilated cardiomyopathy
4.2
13.0
35
87
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.0
12.9
59
209
W79
ICD-10 Finland
Inhalation and ingestion of food causing obstruction of respiratory tract
32.9
12.6
16
5
R4150
NOMESCO Finland
Neuropsychological rehabilitation
13.6
12.5
21
16
G40.9
ICD-10 Finland
Epilepsy, unspecified
4.3
12.2
32
78
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
4.8
12.0
27
58
TPH07
NOMESCO Finland
Cathetrisation of artery
2.5
11.9
84
373
I21.01
ICD-10 Finland
Acute transmural myocardial infarction of anterior wall
5.5
11.9
23
43
FPG32
NOMESCO Finland
Implantation of cardioverter-defibrillator with atrial and ventricular electrodes
11.5
11.6
21
19
T71
ICD-10 Finland
Asphyxiation
+∞
11.5
11
*
WX704
NOMESCO Finland
Intubation
2.9
11.5
56
206
WX882
NOMESCO Finland
High dependency care
4.3
11.2
29
70
UGC12
NOMESCO Finland
Flexible bronchoscopy
2.6
10.9
68
284
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
5.1
10.8
23
47
FPJ21
NOMESCO Finland
Revision of cardioverter-defibrillator with ventricular electrode
61.2
10.7
12
*
R56.8
ICD-10 Finland
Other and unspecified convulsions
3.3
10.7
41
131
ZXD05
NOMESCO Finland
Urgent procedure
1.9
10.5
175
1084
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
5.6
10.5
20
37
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
12.4
10.4
18
15
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.6
10.3
65
274
M01AH05
ATC
etoricoxib; oral
0.5
10.2
151
2298
B01AA03
ATC
warfarin; systemic
2.0
9.9
143
842
I21.00
ICD-10 Finland
Acute transmural myocardial infarction of anterior wall
5.0
9.9
21
43
N18
ICPC
Paralysis/weakness
5.0
9.9
21
43
OAA67, ,
SPAT
0.1
9.6
6
386
R1230
NOMESCO Finland
Neuropsychological evaluation of need and possibilities to rehabilitation
9.3
9.6
19
21
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.8
9.6
183
1178
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
3.1
9.5
40
135
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.6
9.5
59
246
N29
ICPC
Neurological sympt/complt other
5.3
9.4
19
37
N05AH03
ATC
olanzapine; systemic
3.1
9.4
40
136
G45.1
ICD-10 Finland
Carotid artery syndrome (hemispheric)
+∞
9.4
9
*
C03CA01
ATC
furosemide; systemic
1.8
9.4
208
1399
M01AE01
ATC
ibuprofen; systemic, rectal
0.6
9.2
325
3928
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
1.9
9.1
127
737
C09AA05
ATC
ramipril; oral
1.8
9.0
164
1037
FPG40
NOMESCO Finland
Replacement of pulse generator in transvenous cardioverter-defibrillator
19.0
9.0
13
7
AS7
HP
Arrhythmia pacemaker insertion VVI (R) S
19.0
9.0
13
7
G41.9
ICD-10 Finland
Status epilepticus, unspecified
16.6
8.6
13
8
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
2.2
8.6
81
407
G93.0
ICD-10 Finland
Cerebral cysts
+∞
8.4
8
*
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
2.9
8.3
39
141
N02BE01
ATC
paracetamol; systemic, rectal
0.6
8.2
341
4031
C07AB07
ATC
bisoprolol; oral
1.7
8.0
280
2112
I20.81
ICD-10 Finland
Other angina pectoris stenosed coronary artery
2.3
7.9
66
314
N05AA02
ATC
levomepromazine; systemic
3.3
7.9
30
95
PH1AC
NOMESCO Finland
Flebography of over extremity with X-ray
4.7
7.9
18
39
N17.9
ICD-10 Finland
Acute renal failure, unspecified
3.0
7.8
35
123
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
6.1
7.8
20
34
PA1AD
NOMESCO Finland
CT of aortic arch and branches
45.7
7.7
9
*
OAB43, ,
SPAT
0.3
7.7
27
733
205
Kela drug reimbursment
Chronic hypertension
1.7
7.7
164
1080
R40.2
ICD-10 Finland
Coma, unspecified
8.2
7.6
16
20
E11.00
ICD-10 Finland
Non-insulin dependent diabetes diabetic hypoglycaemic coma
3.2
7.4
29
94
I50.1
ICD-10 Finland
Left ventricular failure
2.5
7.3
45
187
GBB03
NOMESCO Finland
Percutaneous tracheostomy
+∞
7.3
7
*
N05BA09
ATC
clobazam; oral
16.0
7.3
11
7
ZXE50
NOMESCO Finland
More than nine and less than 12 hours
4.5
7.0
17
39
L89
ICD-10 Finland
Decubitus ulcer and pressure area
4.1
6.9
19
48
JDB10
NOMESCO Finland
Percutaneous gastrostomy
5.8
6.8
18
32
A10AA02, ,
ATC
3.2
6.8
26
83
FXF00
NOMESCO Finland
Decannulation after ECHLA or ECLA
40.6
6.8
8
*
WW200, ,
SPAT
0.5
6.7
51
1000
X70
ICD-10 Finland
Intentional self-harm by hanging, strangulation and suffocation
22.8
6.7
9
*
ZXE40
NOMESCO Finland
More than seven and less than nine hours
4.1
6.7
18
45
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.4
6.7
46
202
WX890
NOMESCO Finland
Intesive care monitoring
8.0
6.6
14
18
K90
ICPC
Stroke/cerebrovascular accident
3.3
6.6
24
74
XA400
NOMESCO Finland
EEG
12.4
6.6
11
9
I11.9
ICD-10 Finland
Hypertensive heart disease without (congestive) heart failure
2.7
6.6
36
141
N05AD01
ATC
haloperidol; systemic
3.2
6.5
25
80
I42.9
ICD-10 Finland
Cardiomyopathy, unspecified
5.4
6.5
18
34
N03AE01
ATC
clonazepam; systemic
2.7
6.5
35
136
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
1.7
6.5
132
853
Z43.0
ICD-10 Finland
Attention to tracheostomy
70.7
6.4
7
*
I50.0
ICD-10 Finland
Congestive heart failure
2.1
6.4
62
314
TFP30
NOMESCO Finland
Cathetric examination for cardiac arrythmia
11.2
6.3
11
10
E10.00
ICD-10 Finland
Insulin-dependent diabetes diabetic hypoglycemic coma
9.4
6.3
12
13
G91.1
ICD-10 Finland
Obstructive hydrocephalus
+∞
6.3
6
*
FN1YT
NOMESCO Finland
Percutaneous insertion of coronary artery stent
2.4
6.2
44
196
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.4
6.2
41
177
K03.82
ICD-10 Finland
Split tooth for reasons other than trauma
0.5
6.1
45
896
N06AB04
ATC
citalopram; systemic
1.8
6.1
100
606
2500A
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE,TYYPPI II]
3.4
6.1
21
63
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.0
6.0
67
357
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
350
4503
0.36
26.52
38.2
27.1
131.33
135.87
g/l
5.41
344
4450
350
4501
0.36
26.38
41.0
27.6
39.30
40.47
%
3.48
343
4447
350
4501
0.36
26.38
37.8
26.9
4.34
4.50
e12/l
5.77
340
4394
350
4500
0.36
26.31
38.1
27.0
233.21
238.70
e9/l
0.81
338
4411
350
4499
0.36
26.24
37.7
26.9
91.83
91.41
fl
0.86
344
4450
123
456
3.20
25.70
8.3
8.1
8.90
10.85
mmol/l
2.19
116
437
305
4124
0.39
23.74
6.1
5.9
2.40
2.61
mmol/l
3.52
283
3784
294
4021
0.40
22.92
5.3
5.1
1.36
1.38
mmol/l
0.42
277
3687
287
3950
0.41
22.23
7.2
6.8
40.69
40.03
mmol/mol
0.52
270
3679
348
4411
0.40
21.52
33.0
23.6
87.25
85.09
umol/l
0.36
341
4354
292
3975
0.42
21.48
22.6
17.6
80.95
78.25
ml/min/173m2
1.09
277
3699
302
4047
0.42
21.05
5.5
5.3
4.25
4.45
mmol/l
2.31
282
3741
342
4358
0.40
21.04
15.0
12.7
36.06
27.28
u/l
1.97
330
4232
299
3999
0.43
19.94
5.4
5.2
6.21
6.07
mmol/l
0.57
271
3629
290
3874
0.45
17.77
4.9
4.4
1.36
1.30
mmol/l
0.60
271
3524
127
599
2.47
16.14
15.4
8.9
0.39
1.04
mmol/l
0.76
101
488
128
607
2.46
16.07
16.1
8.8
13.31
11.69
kpa
1.52
121
582
128
607
2.46
16.07
16.1
8.8
5.23
5.16
kpa
0.26
122
579
44
112
4.19
15.89
1.8
3.9
37.59
35.56
umol/l
0.13
39
97
347
4288
0.46
15.58
36.1
21.8
4.01
4.01
mmol/l
0.01
339
4195
348
4281
0.46
14.92
36.6
21.5
138.80
139.69
mmol/l
4.76
342
4197
289
3758
0.50
13.77
5.8
4.8
3.46
2.02
mu/l
0.58
264
3403
62
1424
0.36
13.45
3.0
3.3
0.65
0.81
ug/l
1.12
47
940
148
802
2.17
13.31
5.3
3.5
0.86
0.82
mmol/l
1.36
139
756
124
651
2.18
11.94
6.8
6.5
1.09
1.04
mmol/l
1.08
116
604
155
2395
0.50
11.54
4.2
5.7
2.08
3.47
ug/l
1.85
131
2133
87
413
2.32
10.61
3.1
2.7
28.38
7.30
ug/l
2.62
81
366
348
4165
0.53
10.46
26.2
18.0
32.84
27.28
mg/l
2.12
314
3501
115
1914
0.49
10.32
4.4
4.6
21.54
21.59
%
0.01
53
951
237
3159
0.55
10.20
4.2
4.4
13.87
12.83
mm/h
0.37
223
2923
161
2384
0.54
9.79
2.9
2.9
—
—
—
0
0
20
40
5.16
9.64
1.4
1.5
1.59
1.06
promille
0.61
15
32
278
3427
0.61
7.36
30.3
22.4
14.18
13.75
%
4.30
278
3390
51
233
2.31
6.75
2.3
1.9
1.04
1.57
ug/l
0.53
45
205
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
40
167
2.51
6.45
3.4
2.6
0.35
0.34
iu/ml
0.11
26
95
11
10
11.20
6.32
4.4
8.9
5.79
4.64
kpa
—
11
10
20
57
3.61
6.21
10.2
1.9
11.10
10.37
mmol/l
0.59
20
57
113
1692
0.58
6.18
2.1
2.0
1.42
1.36
mmol/l
0.27
102
1408
278
2217
1.53
5.48
24.2
17.8
1.44
1.33
inr
1.91
238
1854
64
347
1.96
5.48
2.0
1.6
—
—
—
0
0
70
402
1.85
5.04
5.2
3.0
232.67
240.13
ng/l
0.06
65
365
172
2245
0.66
4.87
4.7
3.8
0.00
0.00
estimate
-0.00
38
484
181
1344
1.52
4.83
2.7
2.2
342.01
317.71
u/l
0.10
171
1272
176
2283
0.66
4.82
4.9
3.8
0.00
0.68
estimate
0.51
36
451
176
2276
0.66
4.71
4.8
3.8
0.00
3.34
estimate
0.50
39
487
8
8
10.13
4.53
4.8
10.1
12.41
10.63
%
—
8
8
253
3026
0.69
4.33
4.7
3.9
14.94
14.83
pmol/l
0.23
230
2725
156
2042
0.67
4.31
2.3
2.2
97.51
93.11
pmol/l
0.53
88
1133
287
3352
0.69
4.28
9.8
9.0
88.22
82.13
u/l
0.73
278
3178
98
1401
0.63
4.07
1.7
1.7
20.89
19.50
nmol/l
0.36
87
1192
9
17
5.36
3.52
3.2
4.3
87.78
109.29
%
—
9
17
89
1255
0.65
3.38
3.1
3.1
371.28
363.22
umol/l
0.33
78
1091
239
2823
0.72
3.38
4.6
3.5
79.13
56.05
u/l
1.96
215
2650
56
872
0.60
3.28
3.1
3.1
1.16
0.93
e6/l
0.16
32
493
41
688
0.56
3.19
1.3
1.3
26.76
35.66
iu/ml
0.39
12
213
101
1368
0.68
3.10
3.9
3.4
1.20
0.53
e6/l
0.61
82
1021
211
2520
0.73
3.08
10.4
10.2
4.57
4.20
e9/l
1.60
190
2199
31
559
0.53
3.08
4.5
4.8
34.43
31.09
%
0.81
23
370
160
1995
0.72
3.07
3.6
3.1
156.03
157.85
ug/l
0.03
143
1855
39
655
0.56
3.04
1.2
1.3
1.40
11.24
u/ml
3.46
12
254
59
889
0.62
3.00
1.4
1.3
1.31
1.56
u/ml
0.17
14
240
243
2829
0.74
2.93
5.4
4.6
1472.67
767.34
e6/l
—
6
53
149
1859
0.72
2.80
2.6
2.4
69.88
75.79
nmol/l
2.01
131
1664
54
816
0.62
2.77
3.2
3.2
1.00
1.33
e6/l
0.42
30
435
138
1730
0.73
2.64
4.9
3.8
0.00
0.03
estimate
1.32
33
411
39
625
0.59
2.55
1.6
1.4
—
—
—
0
0
125
1565
0.74
2.32
3.7
3.6
61.84
132.45
e6/l
0.80
101
1212
65
907
0.68
2.28
4.7
3.2
2.44
2.45
mmol/l
0.22
53
808
118
921
1.36
2.21
6.5
4.0
4311.50
425.94
ng/l
1.87
107
752
214
1821
1.29
2.18
4.7
4.1
127.97
45.82
ng/l
2.10
181
1380
8
193
0.41
2.09
2.3
1.8
42.63
40.32
nmol/l
—
8
184
71
515
1.44
2.04
7.8
3.9
1.38
1.84
mmol/l
0.59
55
433
13
266
0.48
1.94
2.2
2.5
—
16.64
—
0
20
72
532
1.41
1.88
7.8
3.9
5.86
5.83
kpa
0.06
65
514
100
1258
0.75
1.87
3.7
3.4
0.00
0.10
estimate
0.80
31
371
136
1636
0.77
1.82
3.6
3.5
7.60
8.14
mmol/l
0.60
114
1376
168
1423
1.26
1.71
3.5
2.8
72.68
63.69
u/l
0.30
157
1326
32
205
1.60
1.66
4.0
3.8
4.00
4.52
pmol/l
1.72
26
181
15
76
2.00
1.66
3.4
1.8
125.09
5312.59
u/l
—
7
23
18
100
1.83
1.55
2.1
3.5
0.97
0.82
nmol/l
0.54
13
84
136
1607
0.79
1.53
3.9
4.3
16.08
10.91
mg/mmol
0.44
101
1075
13
242
0.53
1.51
1.1
1.3
—
64.58
—
0
17
103
1249
0.78
1.44
4.4
3.8
0.00
0.01
estimate
0.78
34
430
179
1558
1.22
1.39
4.6
3.4
2640.20
1791.16
ng/l
0.95
167
1355
5
121
0.41
1.39
1.2
1.5
—
—
—
0
0
5
17
2.96
1.36
4.8
3.6
5.40
5.08
kpa
—
5
17
5
17
2.96
1.36
4.8
3.6
13.70
9.99
kpa
—
5
17
0
38
0.00
1.35
0.0
1.2
—
—
—
0
0
9
44
2.06
1.27
2.1
3.0
—
—
—
0
0
59
454
1.34
1.25
3.1
2.5
0.21
0.20
g/l
0.11
54
414
8
36
2.24
1.24
1.4
1.6
—
—
—
0
0
22
142
1.57
1.16
1.5
1.3
—
—
—
0
0
5
114
0.43
1.13
1.2
1.2
—
2.33
—
0
11
10
51
1.98
1.12
1.1
1.2
—
—
—
0
0
7
35
2.01
1.00
1.0
1.1
87.14
98.09
pmol/l
—
7
35
103
883
1.21
0.93
2.2
2.0
—
—
—
0
0
43
333
1.32
0.91
6.9
3.9
3.02
1.96
mmol/l
1.21
31
249
24
334
0.71
0.90
1.6
1.5
—
—
—
0
0
19
127
1.51
0.89
2.6
2.3
125.14
129.20
g/l
0.33
14
98
6
29
2.08
0.89
1.3
1.7
—
—
—
0
0
6
29
2.08
0.89
1.3
1.7
—
—
—
0
0
5
105
0.47
0.89
1.0
1.3
—
—
—
0
0
97
831
1.20
0.88
1.7
1.8
1193.62
1113.84
nmol/l
0.45
76
639
165
1481
1.16
0.88
3.7
3.6
140.82
35.44
u/l
0.96
156
1399
56
454
1.26
0.85
9.0
3.1
4.58
4.47
kpa
0.15
50
439
20
137
1.48
0.85
1.7
1.6
—
—
—
0
0
6
31
1.95
0.84
1.2
1.5
111.00
87.23
umol/l
—
6
31
15
97
1.56
0.82
1.8
1.6
—
—
—
0
0
59
486
1.24
0.79
2.2
1.8
1.77
1.54
%
1.00
51
418
0
26
0.00
0.78
0.0
3.7
—
141.85
—
0
26
14
91
1.55
0.76
2.2
1.4
135.17
160.61
au/ml
—
6
24
14
91
1.55
0.76
1.9
1.6
—
—
—
0
0
26
193
1.36
0.74
1.8
2.0
—
—
—
0
0
12
76
1.59
0.72
1.8
1.6
—
—
—
0
0
257
2407
1.13
0.72
7.5
7.3
12.89
12.38
umol/l
0.11
245
2297
138
1526
0.87
0.70
4.2
3.7
2.34
2.35
mmol/l
0.03
128
1380
73
624
1.20
0.70
2.3
1.9
—
—
—
0
0
5
28
1.79
0.66
2.0
1.6
—
—
—
0
0
43
350
1.25
0.66
4.9
4.2
1.20
1.22
mmol/l
1.18
36
303
88
1001
0.86
0.66
6.1
3.9
1.02
1.02
kg/l
0.20
62
672
5
29
1.73
0.64
1.8
1.4
277.40
277.50
mu/l
—
5
22
13
88
1.49
0.61
1.5
1.2
430.38
505.14
mg/l
0.44
13
83
0
20
0.00
0.60
0.0
1.0
—
—
—
0
0
0
20
0.00
0.60
0.0
1.2
—
12.15
—
0
20
0
21
0.00
0.60
0.0
1.3
—
38.90
—
0
21
33
264
1.27
0.59
1.8
1.4
—
—
—
0
0
0
22
0.00
0.59
0.0
1.1
—
155.15
—
0
22
0
23
0.00
0.58
0.0
1.0
—
—
—
0
0
19
142
1.35
0.55
1.7
1.7
—
—
—
0
0
76
668
1.16
0.55
2.2
1.8
—
—
—
0
0
8
126
0.63
0.55
1.4
1.7
—
—
—
0
0
282
2688
1.10
0.53
12.2
5.5
7.32
6.88
mmol/l
1.64
271
2566
14
191
0.73
0.51
1.1
1.0
—
—
—
0
0
11
75
1.48
0.51
1.4
1.2
1.73
19.12
e6/l
1.11
11
57
23
180
1.29
0.50
1.9
1.8
—
—
—
0
0
218
2057
1.10
0.49
16.3
7.2
1.17
1.20
mmol/l
7.05
204
1894
7
107
0.65
0.49
1.1
1.2
—
—
—
0
0
7
107
0.65
0.49
1.1
1.2
—
—
—
0
0
11
77
1.44
0.46
1.5
1.3
13.45
1568.44
e6/l
0.55
11
61
11
77
1.44
0.46
1.3
1.5
—
—
—
0
0
11
78
1.42
0.43
1.5
1.1
3.82
3.67
mmol/l
0.18
11
73
15
113
1.34
0.43
1.9
1.5
—
—
—
0
0
6
94
0.63
0.42
1.0
1.3
—
—
—
0
0
39
333
1.18
0.42
1.3
1.4
—
—
—
0
0
0
15
0.00
0.41
0.0
1.7
—
7.67
—
0
15
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
10
138
0.72
0.41
2.2
1.5
—
—
—
0
0
55
621
0.87
0.40
2.3
4.4
339.02
254.75
u/l
1.24
50
586
0
18
0.00
0.40
0.0
1.2
—
8.18
—
0
18
0
18
0.00
0.40
0.0
1.8
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
7
105
0.66
0.39
2.4
1.2
—
—
—
0
0
28
334
0.83
0.39
1.6
1.7
—
—
—
0
0
40
345
1.17
0.39
2.9
3.0
63.00
63.69
ml/min/173m2
0.05
23
157
5
37
1.35
0.37
3.8
2.7
0.60
0.86
index
—
5
37
13
168
0.77
0.36
1.2
1.3
—
—
—
0
0
55
491
1.13
0.35
6.0
3.7
—
—
—
0
0
6
43
1.40
0.35
1.8
1.1
—
—
—
0
0
6
44
1.37
0.34
1.5
1.6
—
—
—
0
0
212
2032
1.07
0.32
7.2
5.7
33.30
35.20
g/l
3.73
197
1911
24
202
1.20
0.31
2.5
2.9
—
—
—
0
0
7
54
1.30
0.30
1.0
2.1
—
—
—
0
0
15
120
1.26
0.30
1.5
1.4
—
—
—
0
0
10
75
1.34
0.30
1.0
1.1
—
—
—
0
0
11
85
1.30
0.28
2.1
3.2
—
841.71
—
0
7
16
194
0.82
0.28
1.5
1.6
0.28
0.33
mg/l
—
9
91
8
65
1.23
0.27
5.4
3.1
1.19
1.19
mmol/l
—
8
65
38
338
1.13
0.27
5.4
4.4
113.47
94.97
ng/l
0.35
33
299
5
74
0.67
0.26
1.6
1.5
—
—
—
0
0
12
96
1.26
0.24
1.2
1.8
—
—
—
0
0
14
169
0.82
0.24
4.1
4.2
34.30
49.88
mg/l
—
9
147
14
168
0.83
0.23
4.1
4.2
43.20
96.77
mg/l
—
8
143
101
957
1.07
0.21
1.6
1.8
433.54
22025733.32
pmol/l
0.74
85
790
16
135
1.19
0.21
1.7
1.7
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
0.30
—
0
11
0
10
0.00
0.21
0.0
1.1
—
1.51
—
0
5
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
8
102
0.78
0.21
1.5
1.3
—
—
—
0
0
8
102
0.78
0.21
1.5
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
5
43
1.16
0.21
1.0
1.8
—
—
—
0
0
5
43
1.16
0.21
1.0
1.8
—
—
—
0
0
5
43
1.16
0.21
1.0
1.8
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
50.82
—
0
13
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
6
51
1.18
0.19
1.0
2.2
—
—
—
0
0
13
154
0.84
0.19
2.8
4.0
1.17
2.86
ratio
—
5
86
5
68
0.73
0.17
1.2
1.6
—
—
—
0
0
82
862
0.94
0.17
3.5
2.7
11.37
12.79
umol/l
1.14
75
802
8
68
1.18
0.16
5.4
3.0
105.88
105.60
mmol/l
—
8
68
8
73
1.10
0.15
1.4
1.6
—
—
—
0
0
10
119
0.84
0.15
1.0
1.3
—
—
—
0
0
235
2299
1.04
0.15
14.7
7.8
1.18
1.21
mmol/l
5.96
201
1985
41
439
0.93
0.14
2.6
2.7
39.03
33.67
u/l
0.56
32
369
30
276
1.09
0.14
8.6
2.6
0.62
0.62
%
0.02
30
276
125
1289
0.96
0.13
2.7
2.2
3.14
2.92
mg/l
0.43
104
1115
6
57
1.05
0.08
1.8
1.5
—
—
—
0
0
108
1107
0.97
0.08
3.0
2.5
—
—
—
0
0
6
58
1.03
0.08
1.8
1.5
—
—
—
0
0
6
58
1.03
0.08
1.8
1.5
—
—
—
0
0
6
70
0.86
0.07
1.0
1.3
—
—
—
0
0
8
75
1.07
0.07
6.0
4.0
9.42
10.10
pmol/l
—
8
75
18
167
1.08
0.07
1.6
2.3
—
—
—
0
0
73
750
0.97
0.06
3.8
2.6
20.26
23.02
%
1.05
66
698
48
497
0.96
0.06
3.0
4.9
18.37
32.50
ug/l
0.35
38
417
11
120
0.91
0.05
1.5
1.4
297.17
287.33
ug/g
—
6
74
15
140
1.07
0.04
1.5
1.3
—
—
—
0
0
33
318
1.04
0.04
1.7
1.9
—
—
—
0
0
48
493
0.97
0.04
12.1
7.2
—
—
—
0
0
15
141
1.07
0.03
1.4
2.2
—
—
—
0
0
208
2064
1.01
0.03
3.2
3.0
—
—
estimate
—
0
0
10
108
0.92
0.03
1.5
1.4
—
—
—
0
0
81
803
1.01
0.01
3.5
2.6
2.29
2.23
g/l
0.38
71
745
57
567
1.01
0.00
3.1
3.3
7.92
8.20
umol/l
0.07
47
515
35
348
1.01
0.00
1.8
2.0
—
—
—
0
0
21
209
1.00
0.00
1.2
1.2
95.76
149.09
u/ml
—
8
68
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
3.0
—
4.92
—
0
5
0
8
0.00
0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
97
970
1.00
-0.00
2.0
1.7
2.19
1.59
mg/l
0.76
77
765
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
6
60
1.00
-0.00
1.8
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
5
53
0.94
-0.00
1.2
1.2
—
—
—
0
0
6
62
0.97
-0.00
1.8
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
62
0.97
-0.00
1.8
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint G6_ANOXBRAINDAM and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_ANOXBRAINDAM | 5.632 [4.28, 7.42] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.638 |
During the follow-up period (1.1.1998 — 31.12.2019), 257 out of 594 females with G6_ANOXBRAINDAM died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| G6_ANOXBRAINDAM | 4.447 [3.79, 5.22] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.062 |
During the follow-up period (1.1.1998 — 31.12.2019), 781 out of 1580 males with G6_ANOXBRAINDAM died.
Mortality risk
Mortality risk for people of age
years, who have G6_ANOXBRAINDAM.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.472% | 1.023% |
| 5 | 3.401% | 5.482% |
| 10 | 9.156% | 13.608% |
| 15 | 16.581% | 24.711% |
| 20 | 27.016% | 40.035% |
Relationships between endpoints
↥Index endpoint: G6_ANOXBRAINDAM – Anoxic brain damage
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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