No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
123 |
4. Check minimum number of eventsNone |
123 |
5. Include endpointsNone |
123 |
6. Filter based on genotype QC (FinnGen only) |
111 |
Control definitions (FinnGen only)
- Control exclude
- K11_HERNIA
Extra metadata
- First used in FinnGen datafreeze
- DF3
Similar endpoints
↥List of similar endpoints to
Femoral hernia, bilateral
based on the number of shared cases.
Similar with more cases:
- Femoral hernia
- Inguinal or femoral hernia, bilateral
- Hernia
- Gastrointestinal diseases
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 879 | 487 | 390 |
| Only index persons | 757 | 427 | 330 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.02 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 64.25 | 66.06 | 61.96 |
| Only index persons | 62.17 | 63.86 | 59.99 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 111 | 69 | 42 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | 60.87 | 60.95 | 60.74 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 115
- Matched controls
- 1150
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K41.2
ICD-10 Finland
Bilateral femoral hernia, without obstruction or gangrene
+∞
67.5
58
*
K41.0
ICD-10 Finland
Bilateral femoral hernia, with obstruction, without gangrene
+∞
53.4
47
*
K40.9
ICD-10 Finland
Unilateral or unspecified inguinal hernia, without obstruction or gangrene
169.1
43.2
43
*
JAB30
NOMESCO Finland
Repair of inguinal hernia using prosthetic material
+∞
30.6
28
*
K40.2
ICD-10 Finland
Bilateral inguinal hernia, without obstruction or gangrene
284.3
23.5
23
*
JAB11
NOMESCO Finland
Laparoscopic repair of inguinal hernia
+∞
20.4
19
*
K41.9
ICD-10 Finland
Unilateral or unspecified femoral hernia, without obstruction or gangrene
+∞
14.9
14
*
K43.9
ICD-10 Finland
Other and unspecified ventral hernia without obstruction or gangrene
85.2
13.9
15
*
K41.3
ICD-10 Finland
Unilateral or unspecified femoral hernia, with obstruction, without gangrene
+∞
11.7
11
*
K41.1
ICD-10 Finland
Bilateral femoral hernia, with gangrene
+∞
11.7
11
*
JAC11
NOMESCO Finland
Laparoscopic repair of femoral hernia
+∞
11.7
11
*
JAB10
NOMESCO Finland
Repair of inguinal hernia
+∞
10.6
10
*
K40.3
ICD-10 Finland
Unilateral or unspecified inguinal hernia, with obstruction, without gangrene
+∞
10.6
10
*
JAC10
NOMESCO Finland
Repair of femoral hernia
+∞
9.5
9
*
JA1AE
NOMESCO Finland
Ultrasound examination of groin and abdominal wall
24.1
8.2
11
5
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
20.0
7.8
11
6
A06AD11
ATC
lactulose; oral
3.5
7.6
32
114
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
3.0
7.6
54
263
K42.9
ICD-10 Finland
Umbilical hernia without obstruction or gangrene
+∞
7.4
7
*
J01MA02
ATC
ciprofloxacin; systemic
2.7
6.4
59
323
JAC30
NOMESCO Finland
Repair of femoral hernia using prosthetic material
+∞
6.3
6
*
JAB12
NOMESCO Finland
Laparoscopic repair of inguinal hernia, TEP
+∞
6.3
6
*
D06
ICPC
Abdominal pain localized other
4.4
6.2
17
44
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
67
416
2.46
5.27
3.2
2.5
—
—
estimate
—
0
0
49
294
2.16
3.86
1.6
1.7
20.09
22.36
nmol/l
0.59
44
241
36
206
2.09
3.10
3.3
2.2
—
—
—
0
0
62
435
1.92
2.96
2.1
2.1
94.73
94.94
pmol/l
0.01
43
203
32
182
2.05
2.78
1.3
1.3
18.87
42.02
iu/ml
1.42
14
67
65
478
1.83
2.56
8.7
5.7
1.21
1.22
mmol/l
0.40
58
434
88
718
1.96
2.42
4.7
4.7
14.97
15.04
pmol/l
0.09
80
643
49
342
1.75
2.21
3.3
3.5
3765.79
1638.19
ng/l
0.71
41
291
29
172
1.92
2.21
3.8
3.0
1.00
1.13
e6/l
0.09
18
88
89
741
1.89
2.14
8.2
8.7
72.17
82.26
u/l
2.54
82
690
44
303
1.73
2.06
4.2
3.1
0.24
0.53
e6/l
0.98
33
223
7
25
2.91
1.68
1.1
1.3
—
—
—
0
0
58
450
1.58
1.62
2.4
2.3
81.00
78.36
nmol/l
0.38
52
393
33
223
1.67
1.61
1.8
3.3
2.47
2.47
mmol/l
0.03
27
194
10
45
2.34
1.51
1.0
1.0
—
—
—
0
0
9
39
2.42
1.47
1.3
1.1
—
—
—
0
0
70
576
1.55
1.46
9.3
10.4
4.15
4.14
e9/l
0.01
64
500
53
412
1.53
1.42
5.7
4.3
95.58
168.91
ng/l
0.22
40
308
6
23
2.69
1.38
1.8
1.5
—
—
—
0
0
32
223
1.60
1.37
2.2
1.8
0.72
1.20
mg/l
1.88
24
186
96
858
1.72
1.33
6.2
5.6
1.80
1.95
mu/l
0.73
87
777
28
190
1.63
1.33
3.4
3.7
104.66
114.20
ng/l
0.04
23
154
0
34
0.00
1.18
0.0
1.4
—
—
—
0
0
62
512
1.46
1.17
3.0
2.8
—
—
—
0
0
24
162
1.61
1.16
3.8
3.1
1.68
2.02
e6/l
0.11
12
78
65
543
1.45
1.15
8.9
6.0
1.21
1.22
mmol/l
0.17
54
458
100
917
1.69
1.08
26.1
17.0
26.95
23.76
mg/l
0.42
90
746
7
33
2.19
1.07
1.1
1.2
—
—
—
0
0
93
846
1.52
0.96
4.2
4.4
1.24
1.24
mmol/l
0.01
87
765
11
63
1.82
0.94
12.4
9.4
94.58
94.29
%
0.11
11
63
11
63
1.82
0.94
3.8
2.8
1.86
1.20
%
0.90
11
63
16
103
1.64
0.93
5.0
3.6
—
—
—
0
0
96
882
1.54
0.91
5.0
5.2
1.56
1.51
mmol/l
0.50
90
805
6
29
2.13
0.91
1.2
1.2
—
—
—
0
0
99
916
1.58
0.90
5.8
6.0
2.67
2.70
mmol/l
0.11
92
837
6
31
1.99
0.85
1.3
2.2
—
—
—
0
0
105
989
1.71
0.83
38.2
25.0
92.16
91.51
fl
0.72
105
979
105
989
1.71
0.83
38.8
25.5
38.90
39.80
%
0.72
105
979
11
66
1.74
0.82
12.4
9.0
0.65
0.63
%
0.05
11
66
11
66
1.74
0.82
12.4
8.6
1.70
1.28
%
0.98
11
66
24
176
1.46
0.81
1.9
1.9
—
—
—
0
0
105
990
1.70
0.81
38.9
25.2
130.77
132.92
g/l
0.75
105
980
6
34
1.81
0.77
1.2
1.2
—
—
—
0
0
30
232
1.40
0.77
7.6
4.2
1.02
1.02
kg/l
0.45
21
152
9
56
1.66
0.74
1.2
1.5
—
—
—
0
0
94
872
1.43
0.72
6.2
6.7
39.49
39.61
mmol/mol
0.04
86
805
10
61
1.70
0.71
3.9
2.9
0.44
0.61
%
—
10
61
5
27
1.89
0.69
1.4
1.4
—
—
—
0
0
10
62
1.67
0.67
2.3
1.6
—
—
—
0
0
96
897
1.43
0.67
23.2
17.2
74.29
77.11
ml/min/173m2
0.57
87
837
18
131
1.44
0.64
2.0
1.7
—
—
—
0
0
12
81
1.54
0.60
2.0
1.3
—
—
—
0
0
9
65
1.42
0.52
6.6
6.3
26.00
24.69
mmol/l
—
9
65
95
899
1.33
0.49
5.3
5.1
6.00
5.99
mmol/l
0.02
90
808
19
148
1.34
0.47
13.7
6.3
102.95
104.02
mmol/l
0.39
19
148
45
394
1.23
0.46
1.6
1.9
1.16
1.39
mmol/l
1.52
40
309
37
319
1.24
0.43
5.4
4.1
0.00
0.02
estimate
—
10
118
5
32
1.59
0.43
18.0
3.6
3.84
3.88
mmol/l
—
5
32
17
133
1.33
0.41
1.6
1.5
—
—
—
0
0
10
71
1.45
0.41
1.3
1.3
—
—
—
0
0
0
19
0.00
0.39
0.0
1.4
—
—
—
0
0
5
36
1.41
0.38
1.0
2.4
0.00
0.00
g/l
—
5
31
30
258
1.22
0.36
4.9
5.4
2.26
2.16
ug/l
0.07
25
225
27
314
0.82
0.36
3.5
3.5
0.00
0.00
estimate
—
10
101
59
542
1.18
0.35
5.9
4.1
0.00
12.21
estimate
0.50
13
133
38
336
1.20
0.34
2.0
2.2
123.66
210.21
u/l
0.75
38
317
7
53
1.34
0.31
2.4
1.4
—
—
—
0
0
58
541
1.15
0.26
5.8
4.1
0.00
0.00
estimate
-0.00
13
131
13
105
1.27
0.26
17.3
7.2
—
—
—
0
0
6
80
0.74
0.25
3.5
2.0
3.87
3.47
ratio
—
6
69
15
126
1.22
0.22
2.2
1.8
—
—
—
0
0
5
42
1.20
0.22
2.2
2.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
4.70
—
0
5
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
491.43
—
0
7
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
56.70
—
0
7
58
550
1.11
0.18
5.6
4.1
0.00
0.03
estimate
0.50
12
121
44
416
1.09
0.14
5.9
4.1
0.00
0.03
estimate
—
10
108
10
116
0.85
0.12
1.5
5.2
200.40
240.89
u/l
—
10
111
22
202
1.11
0.11
5.4
4.8
25.89
22.65
%
—
8
99
14
125
1.14
0.10
10.4
6.4
13.09
11.54
kpa
0.47
14
118
14
125
1.14
0.10
10.4
6.4
5.43
5.13
kpa
0.60
14
117
5
45
1.12
0.10
1.2
2.4
27.00
41.41
u/l
—
5
40
35
335
1.06
0.07
3.1
3.7
12.22
8.41
mg/mmol
0.24
23
189
14
148
0.94
0.02
1.9
1.5
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
42.25
—
0
8
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
88.87
—
0
8
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.2
—
83.00
—
0
5
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.4
—
70.40
—
0
5
6
68
0.88
0.00
1.8
2.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.6
—
10.95
—
0
8
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
49.62
—
0
5
0
9
0.00
0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
14.50
—
0
8
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
5
53
0.94
-0.00
2.6
1.9
3.46
3.70
mmol/l
—
5
42
6
60
1.00
-0.00
1.8
1.9
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint FEMHER_BILATERAL and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| FEMHER_BILATERAL | 1.462 [1.18, 1.81] | < 0.001 |
| Birth year | 1.0 [0.99, 1.01] | 0.999 |
During the follow-up period (1.1.1998 — 31.12.2019), 156 out of 427 females with FEMHER_BILATERAL died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| FEMHER_BILATERAL | 1.338 [1.05, 1.71] | 0.021 |
| Birth year | 0.989 [0.98, 1.0] | 0.022 |
During the follow-up period (1.1.1998 — 31.12.2019), 126 out of 348 males with FEMHER_BILATERAL died.
Mortality risk
Mortality risk for people of age
years, who have FEMHER_BILATERAL.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.167% | 0.245% |
| 5 | 0.996% | 1.493% |
| 10 | 2.343% | 3.873% |
| 15 | 4.664% | 7.459% |
| 20 | 7.967% | 12.692% |
Relationships between endpoints
↥Index endpoint: FEMHER_BILATERAL – Femoral hernia, bilateral
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data