cognitive disorder: Disturbances in mental processes related to learning, thinking, reasoning, and judgment.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
156 |
4. Check minimum number of eventsNone |
156 |
5. Include endpointsNone |
156 |
6. Filter based on genotype QC (FinnGen only) |
138 |
Control definitions (FinnGen only)
- Control exclude
- F5_ORGANIC
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- F04-F09
- Name in latin
- Perturbatio mentis organica sive symptomatica non specificata
Similar endpoints
↥List of similar endpoints to
Unspecified organic or symptomatic mental disorder
based on the number of shared cases.
Similar with more cases:
- Organic, including symptomatic, mental disorders
- Psychiatric diseases
- Any prescribed medicine buy
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2094 | 1063 | 995 |
| Only index persons | 1489 | 777 | 712 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.03 | 0.03 |
| Only index persons | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 68.08 | 72.57 | 63.10 |
| Only index persons | 64.41 | 69.43 | 58.93 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 138 | 61 | 77 |
| Unadjusted period prevalence (%) | 0.03 | 0.02 | 0.04 |
| Median age at first event (years) | 68.27 | 67.48 | 68.91 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 144
- Matched controls
- 1440
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
F09
ICD-10 Finland
Unspecified organic or symptomatic mental disorder
+∞
204.9
143
*
N05AX08
ATC
risperidone; systemic
25.2
78.8
67
48
N05AH03
ATC
olanzapine; systemic
32.7
67.0
47
21
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
22.0
60.2
51
35
N05AH04
ATC
quetiapine; oral
9.7
39.5
63
107
N03AG01
ATC
valproic acid; systemic, rectal
18.3
37.8
33
23
N06DX01
ATC
memantine; oral
164.7
26.6
27
*
307
Kela drug reimbursment
Tacrine, donepezil, rivastigmine, galantamine and other major and expensive drugs used to treat Alzheimer's disease
+∞
25.8
24
*
F29
ICD-10 Finland
Unspecified nonorganic psychosis
27.4
24.9
34
16
N05BA06
ATC
lorazepam; systemic, sublingual
10.3
24.1
30
36
F03
ICD-10 Finland
Unspecified dementia
54.9
23.3
27
6
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
8.3
21.4
32
48
N05BA04
ATC
oxazepam; oral
5.0
20.4
68
218
R41.0
ICD-10 Finland
Disorientation, unspecified
28.5
16.6
22
9
F05.9
ICD-10 Finland
Delirium, unspecified
68.0
16.2
18
*
N06AB04
ATC
citalopram; systemic
4.4
15.7
53
167
G30.9
ICD-10 Finland
Alzheimer disease, unspecified
63.7
15.1
17
*
N05AX12
ATC
aripiprazole; systemic
18.3
14.5
22
14
F32.9
ICD-10 Finland
Depressive episode, unspecified
5.3
13.7
32
74
G30.1
ICD-10 Finland
Alzheimer disease with late onset
25.5
13.3
18
8
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
6.3
11.0
20
36
N05AD01
ATC
haloperidol; systemic
12.7
10.9
19
17
N06DA02
ATC
donepezil; oral
35.4
10.5
13
*
N05AA02
ATC
levomepromazine; systemic
10.2
9.9
19
21
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.5
9.8
42
151
N06DA03
ATC
rivastigmine; oral, transdermal
59.1
9.8
11
*
F22.0
ICD-10 Finland
Delusional disorder
32.5
9.6
12
*
F00.20*G30.8
ICD-10 Finland
Dementia in Alzheimer's disease, atypical or mixed type without additional symptoms
106.8
9.5
10
*
F19.1
ICD-10 Finland
Mental and behavioural disorders due to multiple drug use and use of other psychoactive substances, harmful use
+∞
9.5
9
*
F05.8
ICD-10 Finland
Other delirium
39.4
9.2
11
*
IGY99
NOMESCO Finland
Other psychiatric treatment contact
26.0
9.1
12
5
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.9
9.0
67
331
R56.8
ICD-10 Finland
Other and unspecified convulsions
9.2
8.9
18
22
N03AX09
ATC
lamotrigine; oral
11.1
8.8
16
16
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
29.5
8.6
11
*
R44.3
ICD-10 Finland
Hallucinations, unspecified
95.4
8.5
9
*
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
4.5
8.2
22
56
AA1AD
NOMESCO Finland
CT of head and brain
2.8
8.0
55
257
F20.9
ICD-10 Finland
Schizophrenia, unspecified
11.8
8.0
14
13
N05BA01
ATC
diazepam; systemic, rectal
3.5
7.9
32
110
G30.8
ICD-10 Finland
Other Alzheimer disease
47.6
7.8
9
*
F31.7
ICD-10 Finland
Bipolar affective disorder, currently in remission
26.6
7.7
10
*
N06AB03
ATC
fluoxetine; oral
3.7
7.6
27
85
SPAT1254
SPAT
Administration of medicine
3.4
7.5
32
113
F31.0
ICD-10 Finland
Bipolar affective disorder, current episode hypomanic
84.2
7.5
8
*
T36
ICD-10 Finland
Poisoning by systemic antibiotics
10.2
7.5
14
15
N05AN01
ATC
lithium; oral
21.3
7.2
10
5
A28
ICPC
Limited function/disability NOS
2.9
7.2
41
172
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
6.5
7.2
18
31
N06AX11
ATC
mirtazapine; oral
2.6
7.1
58
294
F10.20
ICD-10 Finland
Alcohol dependence currently independent
14.7
7.0
11
8
N05AH02
ATC
clozapine; systemic
11.8
6.9
12
11
N03AE01
ATC
clonazepam; systemic
7.1
6.9
16
25
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
17.8
6.8
10
6
N05CF01
ATC
zopiclone; oral
2.5
6.8
64
345
N05CD07
ATC
temazepam; oral
3.1
6.8
34
132
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
4.6
6.8
17
41
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
4.1
6.7
20
55
N05AB03
ATC
perphenazine; systemic, rectal
9.4
6.7
13
15
IEY05
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, individual
9.4
6.7
13
15
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
15.2
6.5
10
7
2989X
ICD-9 Finland
Other nonorganic psychoses, Unspecified psychosis
72.9
6.5
7
*
F00.10*G30.1
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, senile onset without additional symptoms
72.9
6.5
7
*
N06DA04
ATC
galantamine; oral
72.9
6.5
7
*
A06AD11
ATC
lactulose; oral
2.8
6.3
39
170
F06.0
ICD-10 Finland
Organic hallucinosis
+∞
6.3
6
*
EBA15
NOMESCO Finland
Extraction of multiple teeth
9.2
6.2
12
14
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
6.6
6.2
15
25
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
4.2
6.2
17
44
ICB01
NOMESCO Finland
Psychiatric treatment plan, standard
10.7
6.1
11
11
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
66
337
2.77
8.16
2.8
2.0
391.88
215.55
u/l
0.40
60
323
42
168
3.12
8.12
1.8
1.8
1136.37
1169.89
nmol/l
0.08
29
133
83
533
2.32
5.69
11.9
7.3
1.23
1.21
mmol/l
1.24
77
460
26
111
2.64
4.30
4.1
3.9
—
—
—
0
0
7
8
9.12
3.81
26.0
21.0
1213.71
1319.38
nmol/l
—
7
8
58
372
1.94
3.53
3.2
3.3
2.35
2.35
mmol/l
0.01
53
337
13
40
3.47
3.24
1.5
1.2
—
—
—
0
0
30
157
2.15
3.15
2.8
1.7
—
—
—
0
0
65
449
1.82
3.04
3.2
2.2
91.60
96.38
pmol/l
0.32
31
232
0
74
0.00
2.87
0.0
2.0
—
3.32
—
0
54
5
6
8.57
2.77
2.4
1.2
—
—
—
0
0
12
43
2.95
2.72
1.1
1.0
—
—
—
0
0
30
168
1.99
2.62
3.3
3.4
3.48
3.65
e6/l
0.03
14
86
34
201
1.91
2.55
3.1
1.9
—
—
—
0
0
47
311
1.76
2.45
2.1
1.8
21.22
21.93
nmol/l
0.11
42
252
25
138
1.98
2.27
7.0
8.0
2.49
0.48
mmol/l
1.55
17
106
13
56
2.45
2.12
2.3
1.3
—
—
—
0
0
78
609
1.61
2.10
18.3
10.7
4.85
4.19
e9/l
1.17
64
521
26
151
1.88
2.04
3.0
1.8
—
—
—
0
0
8
27
3.08
1.97
1.1
1.4
—
—
—
0
0
8
27
3.08
1.97
1.1
1.4
—
—
—
0
0
30
187
1.76
1.89
3.3
3.2
0.74
0.85
e6/l
0.18
14
106
33
214
1.70
1.81
3.0
2.8
2.50
2.46
mmol/l
0.76
28
186
72
571
1.52
1.69
5.8
6.9
9.44
12.77
umol/l
1.89
67
547
13
64
2.13
1.60
2.7
1.5
—
—
—
0
0
38
274
1.53
1.35
2.9
2.1
2.73
3.20
mg/l
0.75
32
241
24
157
1.63
1.28
9.0
7.6
99.33
104.41
mmol/l
1.82
24
157
6
25
2.46
1.25
1.7
1.5
—
1.95
—
0
6
5
19
2.69
1.22
1.0
1.2
—
—
—
0
0
42
316
1.46
1.21
4.2
3.5
0.18
0.38
e6/l
1.07
29
235
0
34
0.00
1.17
0.0
2.0
—
3.90
—
0
34
45
349
1.42
1.10
4.6
4.5
8.33
10.26
mg/mmol
0.16
28
222
13
75
1.81
1.07
8.3
7.9
24.70
24.49
mmol/l
0.06
13
75
67
561
1.36
1.03
3.1
3.2
—
—
—
0
0
88
984
0.73
1.03
5.5
5.3
4.25
4.51
mmol/l
1.46
81
904
0
31
0.00
0.97
0.0
2.2
—
214.10
—
0
31
88
979
0.74
0.95
5.4
5.1
1.32
1.43
mmol/l
2.29
80
897
6
27
2.27
0.94
1.3
1.2
—
—
—
0
0
50
405
1.36
0.94
4.9
3.6
—
—
—
0
0
84
940
0.74
0.93
4.5
4.4
1.41
1.28
mmol/l
0.64
76
859
6
28
2.19
0.92
1.7
1.4
—
—
—
0
0
15
96
1.63
0.88
1.6
1.5
—
—
—
0
0
6
30
2.04
0.88
1.2
1.9
—
—
—
0
0
17
113
1.57
0.87
2.3
2.9
5.33
11.46
umol/l
1.19
12
101
6
31
1.98
0.85
1.8
1.3
—
—
—
0
0
6
34
1.80
0.77
1.2
1.2
—
—
—
0
0
6
34
1.80
0.77
1.2
1.2
—
—
—
0
0
92
1005
0.77
0.77
6.3
5.9
2.40
2.61
mmol/l
1.42
80
924
5
23
2.21
0.77
17.4
3.1
14.70
8.67
pmol/l
—
5
23
46
379
1.31
0.76
4.2
3.2
1855.42
1833.29
ng/l
0.01
37
307
5
24
2.12
0.75
1.2
1.3
—
—
—
0
0
5
26
1.96
0.71
1.2
1.2
—
—
—
0
0
12
77
1.61
0.71
13.0
10.1
93.80
95.09
%
0.66
12
77
65
565
1.27
0.71
4.7
4.2
0.00
13.10
estimate
0.50
14
124
5
27
1.88
0.69
7.2
3.1
119.80
129.85
g/l
—
5
20
65
568
1.26
0.67
4.7
4.2
0.00
0.00
estimate
-0.00
13
114
0
22
0.00
0.60
0.0
1.1
—
—
—
0
0
6
36
1.69
0.57
1.2
1.2
26.95
24.54
iu/l
—
6
30
26
323
0.76
0.57
3.4
4.9
21.00
22.48
%
—
6
172
81
736
1.23
0.56
5.5
4.4
14.86
15.04
pmol/l
0.27
76
676
32
262
1.28
0.55
1.9
2.6
—
—
—
0
0
49
423
1.24
0.54
5.9
4.3
34.54
39.01
ng/l
0.13
38
315
63
560
1.22
0.53
4.7
4.1
0.00
0.00
estimate
-0.00
13
118
12
84
1.47
0.51
1.7
1.7
—
—
—
0
0
8
118
0.66
0.48
1.8
1.4
—
—
—
0
0
5
31
1.63
0.43
1.6
1.9
—
—
—
0
0
15
114
1.35
0.43
8.8
7.5
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
17
0.00
0.41
0.0
1.5
—
—
—
0
0
5
34
1.49
0.41
1.4
1.2
—
—
—
0
0
0
18
0.00
0.40
0.0
3.3
—
—
—
0
0
5
35
1.44
0.39
6.8
2.6
26.20
24.98
mmol/l
—
5
35
36
311
1.21
0.39
4.0
3.7
0.00
0.02
estimate
—
10
93
29
246
1.22
0.38
4.9
4.6
1.02
1.02
kg/l
1.02
20
160
84
785
1.17
0.37
5.0
4.5
12.81
13.00
mm/h
0.03
74
718
104
1087
0.84
0.35
50.2
25.7
4.36
4.47
e12/l
1.22
97
1062
13
165
0.77
0.34
1.2
1.5
—
9.67
—
0
69
7
52
1.36
0.31
1.3
1.3
—
—
—
0
0
12
94
1.30
0.29
1.8
1.7
—
—
—
0
0
5
38
1.33
0.23
2.2
1.9
—
—
—
0
0
5
41
1.23
0.22
4.8
1.8
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
95
914
1.12
0.21
7.1
5.2
2.00
1.88
mu/l
0.45
88
820
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
197.90
—
0
12
0
12
0.00
0.21
0.0
5.6
—
113.25
—
0
12
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
43
463
0.90
0.19
4.4
2.9
121.89
118.83
ug/l
0.04
37
431
94
967
0.92
0.14
29.5
16.6
80.65
78.42
ml/min/173m2
0.34
83
896
16
180
0.88
0.14
1.1
1.4
11.12
39.27
iu/ml
—
6
60
12
105
1.16
0.11
2.7
2.9
0.03
0.55
e6/l
0.76
12
99
45
428
1.07
0.11
4.4
4.2
0.00
0.02
estimate
0.49
11
94
43
409
1.07
0.11
2.0
2.0
1.43
1.36
mmol/l
0.21
36
333
5
43
1.17
0.10
2.0
3.0
—
—
—
0
0
5
44
1.14
0.10
1.2
1.4
—
0.07
—
0
11
6
55
1.09
0.09
3.7
1.9
0.44
5.61
ug/l
—
6
50
99
972
1.06
0.08
6.5
5.3
6.42
5.97
mmol/l
1.33
91
880
7
66
1.06
0.08
6.4
3.2
2.07
1.46
mmol/l
—
7
53
30
288
1.05
0.05
2.3
3.2
323.26
344.06
umol/l
0.45
19
251
17
163
1.05
0.01
1.4
1.5
—
—
—
0
0
22
226
0.97
0.00
1.8
1.3
0.22
2.12
u/ml
—
5
56
100
1006
0.98
0.00
32.4
17.1
27.82
27.02
mg/l
0.10
92
844
95
952
0.99
0.00
9.5
6.6
42.90
39.89
mmol/mol
1.48
88
890
0
6
0.00
0.00
0.0
3.7
—
53.50
—
0
6
0
6
0.00
0.00
0.0
1.3
—
91.67
—
0
6
0
6
0.00
0.00
0.0
2.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
2.3
—
—
—
0
0
0
6
0.00
0.00
0.0
2.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
2.3
—
—
—
0
0
0
6
0.00
0.00
0.0
2.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
10.83
—
0
6
0
6
0.00
0.00
0.0
1.0
—
1835.50
—
0
6
7
78
0.89
-0.00
1.4
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
13.13
—
0
8
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
14.25
—
0
8
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
34
340
1.00
-0.00
4.5
4.1
0.00
0.00
estimate
—
9
110
0
5
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
1.64
—
0
5
0
7
0.00
-0.00
0.0
1.3
—
8.86
—
0
7
25
250
1.00
-0.00
2.2
1.8
1.43
1.87
mg/l
0.23
20
207
0
7
0.00
-0.00
0.0
2.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
7.06
—
0
7
48
480
1.00
-0.00
2.9
2.8
—
—
estimate
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint F5_UNSORG and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_UNSORG | 3.123 [2.53, 3.86] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.371 |
During the follow-up period (1.1.1998 — 31.12.2019), 515 out of 887 females with F5_UNSORG died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_UNSORG | 3.978 [2.97, 5.33] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.012 |
During the follow-up period (1.1.1998 — 31.12.2019), 482 out of 830 males with F5_UNSORG died.
Mortality risk
Mortality risk for people of age
years, who have F5_UNSORG.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.285% | 0.828% |
| 5 | 1.639% | 4.349% |
| 10 | 4.299% | 11.111% |
| 15 | 9.38% | 19.664% |
| 20 | 14.909% | 33.032% |
Relationships between endpoints
↥Index endpoint: F5_UNSORG – Unspecified organic or symptomatic mental disorder
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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