mental retardation: ['Subnormal intellectual functioning which originates during the developmental period. This has multiple potential etiologies, including genetic defects and perinatal insults. Intelligence quotient (IQ) scores are commonly used to determine whether an individual is mentally retarded. IQ scores between 70 and 79 are in the borderline mentally retarded range. Scores below 67 are in the retarded range. (Joynt, Clinical Neurology, 1992, Ch55, p28)']
Kela-code for behavioural disturbances in mental retardation
DOID EFO Endpoint Browser PheWeb
F5_KELARET
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
416 |
4. Check minimum number of eventsNone |
416 |
5. Include endpointsNone |
416 |
6. Filter based on genotype QC (FinnGen only) |
283 |
Control definitions (FinnGen only)
- Control exclude
- F5_MENTRET
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
Kela-code for behavioural disturbances in mental retardation
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 12361 | 5572 | 6725 |
| Only index persons | 9845 | 4324 | 5521 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.17 | 0.16 | 0.19 |
| Only index persons | 0.19 | 0.16 | 0.21 |
| Median age at first event (years) | |||
| Whole population | 25.49 | 28.68 | 22.73 |
| Only index persons | 24.12 | 26.82 | 22.01 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 283 | 136 | 147 |
| Unadjusted period prevalence (%) | 0.06 | 0.05 | 0.07 |
| Median age at first event (years) | 24.43 | 26.09 | 22.89 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 307
- Matched controls
- 3070
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
113
Kela drug reimbursment
Anxiety disorders associated with mental retardation
+∞
307.7
307
*
N05AC02
ATC
thioridazine; oral
54.7
137.9
81
20
N05AX08
ATC
risperidone; systemic
16.3
130.6
145
160
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
16.4
114.8
117
111
N03AG01
ATC
valproic acid; systemic, rectal
15.1
94.7
97
91
N05AH03
ATC
olanzapine; systemic
13.4
87.7
97
102
F70.0
ICD-10 Finland
Mild mental retardation, With the statement of no, or minimal, impairment of behaviour
+∞
85.5
78
*
N05AA02
ATC
levomepromazine; systemic
18.1
84.8
75
54
N04AA02
ATC
biperiden; systemic
32.0
76.0
51
19
F20.9
ICD-10 Finland
Schizophrenia, unspecified
26.0
74.4
54
25
F70.1
ICD-10 Finland
Mild mental retardation, Significant impairment of behaviour requiring attention or treatment
+∞
69.5
64
*
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
12.3
66.4
74
77
N05AD01
ATC
haloperidol; systemic
15.2
51.4
48
37
N03AF01
ATC
carbamazepine; oral, rectal
10.1
48.0
60
72
N05AF03
ATC
chlorprothixene; systemic
16.0
47.7
43
31
F70.9
ICD-10 Finland
Mild mental retardation, Without mention of impairment of behaviour
494.2
44.4
43
*
N05AB03
ATC
perphenazine; systemic, rectal
11.4
43.0
48
49
P85
ICPC
Mental retardation
+∞
42.7
40
*
G40.9
ICD-10 Finland
Epilepsy, unspecified
11.5
39.9
44
44
A06AD11
ATC
lactulose; oral
5.1
36.7
101
270
N05BA01
ATC
diazepam; systemic, rectal
5.2
36.5
95
242
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
6.5
36.0
68
129
31199
ICD-8 Finland
Mild mental retardation, Other and unspecified
+∞
34.0
32
*
F20.00
ICD-10 Finland
Paranoid schizophrenia continuous
13.7
32.0
31
25
F71.1
ICD-10 Finland
Moderate mental retardation, significant impairment of behaviour requiring attention or treatment
+∞
30.7
29
*
N05AX12
ATC
aripiprazole; systemic
8.7
29.6
40
52
31099
ICD-8 Finland
Borderline mental retardation, Other and unspecified
+∞
28.6
27
*
N05BA06
ATC
lorazepam; systemic, sublingual
6.5
27.4
49
87
F29
ICD-10 Finland
Unspecified nonorganic psychosis
8.1
27.4
39
54
N05AH04
ATC
quetiapine; oral
4.0
27.3
103
342
P72
ICPC
Schizophrenia
10.9
25.1
28
28
P99
ICPC
Psychological disorders other
9.0
24.8
32
39
3170A
ICD-9 Finland
Mild mental retardation[LIEVÄ ÄLYLL.KEHITYSVAMMAISUUS,EI KÄYTÄYTYM.HÄIRIÖTÄ]
+∞
23.2
22
*
N03AX09
ATC
lamotrigine; oral
6.3
22.8
41
73
3170B
ICD-9 Finland
Mild mental retardation[LIEVÄ ÄLYLL.KEHITYSVAMMAISUUS,JOSSA KÄYTÄYTYM.HÄIRI]
+∞
22.1
21
*
OAB43, ,
SPAT
0.0
20.7
*
536
F79.0
ICD-10 Finland
Unspecified mental retardation, with the statement of no, or minimal, impairment of behaviour
+∞
20.0
19
*
N05CD07
ATC
temazepam; oral
4.2
20.0
61
171
N06AB04
ATC
citalopram; systemic
3.4
19.9
97
372
J18.9
ICD-10 Finland
Pneumonia, unspecified
3.1
19.4
124
557
F79.9
ICD-10 Finland
Unspecified mental retardation, without mention of impairment of behaviour
+∞
18.9
18
*
N05AD03
ATC
melperone; systemic
24.6
18.1
25
11
Z02.4
ICD-10 Finland
Examination for driving licence
0.1
17.9
6
573
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
4.2
17.7
52
141
N05AH02
ATC
clozapine; systemic
15.3
17.2
28
20
F71.0
ICD-10 Finland
Moderate mental retardation, with the statement of no, or minimal, impairment of behaviour
+∞
16.8
16
*
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
3.5
16.7
68
231
N05AF05
ATC
zuclopenthixol; systemic
26.2
16.2
22
9
N05AC01
ATC
periciazine; systemic
50.4
16.2
19
*
N05BE01
ATC
buspirone; oral
6.8
16.1
26
41
SPAT1229
SPAT
Assessment of need for aid
4.3
15.8
44
114
31109
ICD-8 Finland
Mild mental retardation, Following infections and intoxications, Unspecified
+∞
15.8
15
*
N05BA04
ATC
oxazepam; oral
2.7
14.7
109
517
N03AF02
ATC
oxcarbazepine; oral
6.2
14.7
26
45
F83
ICD-10 Finland
Mixed specific developmental disorders
38.1
14.6
18
5
183
Kela drug reimbursment
Lamotrigin and topiramate
18.1
14.5
22
13
F70
ICD-10 Finland
Mild mental retardation
+∞
13.6
13
*
34599
ICD-8 Finland
Epilepsy, Other and unspecified
27.2
13.5
18
7
G03DC03
ATC
lynestrenol; oral
13.0
13.3
23
19
30041
ICD-8 Finland
Neuroses, Depressiva
18.3
12.7
19
11
F79.1
ICD-10 Finland
Unspecified mental retardation, significant impairment of behaviour requiring attention or treatment
+∞
12.6
12
*
31009
ICD-8 Finland
Borderline mental retardation, Following infections and intoxications, Unspecified
135.3
12.5
13
*
K59.09
ICD-10 Finland
Constipation, unspecified
3.7
12.4
42
125
M01AH05
ATC
etoricoxib; oral
0.4
12.4
81
1480
K03.66
ICD-10 Finland
Tooth plaque
3.6
12.2
43
132
M01AB05
ATC
diclofenac; systemic, rectal
0.4
12.1
93
1595
30180
ICD-8 Finland
Personality disorders, Immatura
31.4
11.8
15
5
31299
ICD-8 Finland
Moderate mental retardation, Other and unspecified
+∞
11.5
11
*
31000
ICD-8 Finland
Borderline mental retardation, Following infections and intoxications, Post infectionem praenatalem
+∞
11.5
11
*
3199A
ICD-9 Finland
Unspecified mental retardation[MUU ÄLYLLINEN KEHITYSVAMMAISUUS,EI KÄYTTÄYTYMIHÄIRI]
+∞
11.5
11
*
EBA15
NOMESCO Finland
Extraction of multiple teeth
5.3
11.2
23
46
N05BA09
ATC
clobazam; oral
45.0
11.0
13
*
188
Kela drug reimbursment
Psychosis requiring demanding treatment
45.0
11.0
13
*
A98
ICPC
Health maint/preventive medicine
0.4
10.8
241
2791
N06AA12
ATC
doxepin; systemic
4.1
10.8
31
82
M03BX02
ATC
tizanidine; oral
0.4
10.8
81
1430
F71.9
ICD-10 Finland
Moderate mental retardation, without mention of impairment of behaviour
+∞
10.5
10
*
29599
ICD-8 Finland
Schizophrenia, Unspecified type
33.8
10.4
13
*
G40.2
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
17.4
10.0
15
9
OAA65, ,
SPAT
0.1
9.9
*
295
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
10.0
9.9
19
20
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
10.0
9.9
19
20
SPAT1301
SPAT
No procedures
2.2
9.8
117
669
A28
ICPC
Limited function/disability NOS
2.5
9.6
74
349
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
4.2
9.5
26
66
F20.5
ICD-10 Finland
Residual schizophrenia
31.1
9.5
12
*
F72.1
ICD-10 Finland
Severe mental retardation, significant impairment of behaviour requiring attention or treatment
+∞
9.4
9
*
F72.0
ICD-10 Finland
Severe mental retardation, with the statement of no, or minimal, impairment of behaviour
+∞
9.4
9
*
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
2.4
9.3
75
362
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
8.7
9.2
19
23
U04
ICPC
Incontinence urine
3.7
9.2
30
87
N05AA01
ATC
chlorpromazine; systemic, rectal
12.0
9.2
16
14
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.6
9.1
62
276
C03CA01
ATC
furosemide; systemic
2.2
9.0
113
653
R56.8
ICD-10 Finland
Other and unspecified convulsions
3.9
8.9
27
74
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.4
8.9
75
368
G21.1
ICD-10 Finland
Other drug-induced secondary parkinsonism
51.5
8.7
10
*
29999
ICD-8 Finland
Unspecified psychosis
20.7
8.5
12
6
R32
ICD-10 Finland
Unspecified urinary incontinence
5.1
8.5
18
37
F84.0
ICD-10 Finland
Childhood autism
92.5
8.5
9
*
F84.9
ICD-10 Finland
Pervasive developmental disorder, unspecified
92.5
8.5
9
*
OAA67, ,
SPAT
0.1
8.4
*
260
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
2.9
8.4
41
153
K59.0
ICD-10 Finland
Constipation
3.4
8.4
32
103
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
2.1
8.1
107
626
-1, ,
ICPC
4.3
8.1
21
51
G40.20
ICD-10 Finland
Complex partial seizures with only alteration of consciousness
10.4
8.1
15
15
P28
ICPC
Limited function/disability (P)
22.7
8.1
11
5
SPAT1254
SPAT
Administration of medicine
2.4
8.0
60
279
R01AD09
ATC
mometasone; nasal
0.4
7.9
50
990
N03AE01
ATC
clonazepam; systemic
3.5
7.9
28
86
J01FA10
ATC
azithromycin; systemic
0.5
7.7
84
1355
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
4.0
7.7
22
58
SCA02
NOMESCO Finland
Preventive oral health care
2.7
7.7
44
179
M01AE01
ATC
ibuprofen; systemic, rectal
0.5
7.7
203
2456
N39.4
ICD-10 Finland
Other specified urinary incontinence
3.0
7.6
35
126
N05BA05
ATC
potassium clorazepate; oral
11.3
7.4
13
12
N05AL01
ATC
sulpiride; systemic
9.7
7.4
14
15
3180A
ICD-9 Finland
Other specified mental retardation, Moderate mental retardation[KESKIVAIKEA ÄLYLL KEHITYSVAMMAISUUS,EI KÄYTÄYT.HÄIR]
+∞
7.3
7
*
31100
ICD-8 Finland
Mild mental retardation, Following infections and intoxications, Post infectionem praenatalem
+∞
7.3
7
*
C10AX09
ATC
ezetimibe; oral
0.2
7.0
9
365
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.3
7.0
59
287
3820A
ICD-9 Finland
Suppurative and unspecified otitis media, Acute suppurative otitis media
14.2
6.9
11
8
OAA80, ,
SPAT
0.0
6.9
*
167
F20.8
ICD-10 Finland
Other schizophrenia
41.0
6.8
8
*
Z02.7
ICD-10 Finland
Issue of medical certificate
2.9
6.8
33
123
N03AX11
ATC
topiramate; oral
5.7
6.7
18
33
N06AX03
ATC
mianserin; oral
3.6
6.7
22
64
3018X
ICD-9 Finland
Personality disorders, Other personality disorders[MUU TAI SEKAMUOTOINEN PERSOONALLISUUSHÄIRIÖ]
12.6
6.6
11
9
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
2.0
6.6
88
512
R11
ICD-10 Finland
Nausea and vomiting
2.6
6.6
41
174
2959A
ICD-9 Finland
Schizophrenic psychoses, Unspecified schizophrenia[ERILAISTUMATON SKITSOFRENIA,TARKEMMIN MÄÄRITTELEMÄT]
71.3
6.4
7
*
78159
ICD-8 Finland
Other symptoms referable to nervous system and special senses, Laesio loquendi alia sive NUD
71.3
6.4
7
*
SPAT1234
SPAT
Support of social functional capacity
3.1
6.4
27
92
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.9
6.4
108
679
R95
ICPC
Chron obstructive pulmonary disease
4.2
6.4
17
42
M75.1
ICD-10 Finland
Rotator cuff syndrome
0.3
6.4
20
556
F20.30
ICD-10 Finland
Undifferentiated schizophrenia continuous
8.4
6.4
13
16
N02AJ06
ATC
codeine and paracetamol; systemic
0.5
6.4
55
985
N05AN01
ATC
lithium; oral
5.2
6.3
18
36
Q90.9
ICD-10 Finland
Down syndrome, unspecified
+∞
6.3
6
*
A46
ICD-10 Finland
Erysipelas
2.2
6.2
57
288
R62.0
ICD-10 Finland
Delayed milestone
12.9
6.1
10
8
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
202
2596
0.35
15.75
5.9
5.9
2.40
2.67
mmol/l
5.30
190
2413
197
2543
0.37
14.53
4.9
5.0
1.28
1.44
mmol/l
7.69
185
2354
200
2556
0.38
13.98
5.1
5.1
4.25
4.57
mmol/l
5.15
189
2384
246
2841
0.33
12.52
37.4
24.7
4.41
4.52
e12/l
2.84
240
2788
246
2841
0.33
12.52
37.6
24.9
131.76
136.19
g/l
4.69
240
2820
246
2841
0.33
12.52
37.8
25.4
39.31
40.54
%
2.60
240
2818
246
2840
0.33
12.42
37.3
24.7
90.65
90.91
fl
0.35
240
2820
246
2839
0.33
12.32
38.0
24.8
239.86
246.42
e9/l
0.83
240
2798
189
2431
0.42
11.55
4.3
4.3
1.51
1.27
mmol/l
2.56
178
2244
18
13
14.62
11.11
4.2
3.5
32.73
32.80
umol/l
—
12
8
235
2752
0.38
10.83
13.4
12.3
24.25
26.93
u/l
1.00
228
2679
200
2485
0.44
9.99
20.9
15.9
90.19
81.22
ml/min/173m2
5.84
183
2283
245
2757
0.45
6.75
28.6
21.6
71.04
78.20
umol/l
2.11
240
2731
104
643
1.93
6.54
7.3
4.3
1.02
1.02
kg/l
0.17
76
431
209
2457
0.53
5.85
9.1
6.6
41.46
39.43
mmol/mol
1.86
201
2310
214
2486
0.54
5.43
6.6
5.2
6.27
5.99
mmol/l
2.13
203
2289
125
875
1.72
4.97
3.1
2.7
68.22
66.62
u/l
0.03
117
813
41
204
2.17
4.59
2.1
3.6
82.69
193.40
ng/l
2.60
35
187
234
2616
0.56
4.30
25.3
16.6
31.32
24.47
mg/l
2.01
210
2156
29
582
0.45
4.29
2.2
3.1
0.60
0.74
ug/l
0.36
19
371
144
1804
0.62
4.10
4.0
3.5
64.56
50.55
u/l
0.29
133
1708
59
354
1.83
3.89
2.4
2.0
—
—
—
0
0
6
5
12.20
3.78
3.0
2.0
26.05
15.96
umol/l
—
6
5
38
662
0.51
3.69
2.5
2.4
—
—
—
0
0
75
491
1.70
3.65
2.4
2.0
—
—
—
0
0
0
87
0.00
3.36
0.0
1.8
—
3.60
—
0
60
244
2664
0.59
3.23
27.8
20.1
4.01
3.98
mmol/l
1.14
236
2612
59
374
1.71
3.21
2.5
1.9
—
—
—
0
0
27
503
0.49
3.18
1.4
1.3
41.93
36.26
iu/ml
0.11
11
150
244
2662
0.59
3.17
27.7
20.0
139.08
139.66
mmol/l
2.00
237
2615
54
337
1.73
3.11
5.8
10.5
4.00
0.92
mmol/l
4.58
47
288
0
78
0.00
3.00
0.0
1.2
—
—
—
0
0
81
1098
0.64
2.90
1.8
2.0
1.42
1.36
mmol/l
0.27
76
916
67
455
1.60
2.79
1.5
1.7
1134.85
1215.10
nmol/l
0.33
56
356
93
1209
0.67
2.65
2.7
2.9
101.98
127.86
ug/l
0.82
85
1123
6
11
5.54
2.55
9.2
4.4
5.89
4.63
kpa
—
6
11
6
11
5.54
2.55
9.2
4.4
10.02
10.70
kpa
—
6
11
49
720
0.62
2.45
2.2
3.0
328.17
354.35
umol/l
1.04
42
633
75
540
1.51
2.41
4.5
4.1
243.02
464.18
ng/l
0.48
60
432
134
1083
1.42
2.36
6.3
4.1
0.00
0.01
estimate
0.80
19
255
28
156
1.87
2.35
1.7
1.4
—
—
—
0
0
73
973
0.67
2.28
4.4
5.3
1.83
2.28
ug/l
0.28
65
877
102
1274
0.70
2.23
2.9
2.8
—
—
estimate
—
0
0
12
48
2.56
2.21
2.3
1.6
—
—
—
0
0
29
461
0.59
1.98
1.5
1.3
11.88
10.51
u/ml
—
10
183
18
325
0.53
1.92
5.0
4.8
27.00
31.46
%
2.57
11
208
16
297
0.51
1.87
2.2
2.3
—
—
—
0
0
222
2402
0.73
1.68
6.9
5.2
2.03
1.93
mu/l
0.61
210
2196
60
789
0.70
1.67
4.1
4.3
18.99
21.59
%
0.81
19
365
42
293
1.50
1.57
7.7
8.0
—
—
—
0
0
16
279
0.55
1.54
1.6
2.1
—
—
—
0
0
12
58
2.11
1.51
1.2
1.7
—
—
—
0
0
30
199
1.56
1.41
1.8
1.8
—
—
—
0
0
0
38
0.00
1.35
0.0
1.2
—
—
—
0
0
181
1987
0.78
1.29
4.4
4.5
13.34
11.47
mm/h
1.20
170
1840
11
55
2.04
1.29
1.2
1.7
—
—
—
0
0
69
550
1.33
1.23
1.8
1.8
427.66
24947149.80
pmol/l
0.50
61
469
13
71
1.87
1.21
1.2
1.7
—
—
—
0
0
0
35
0.00
1.16
0.0
1.2
—
—
—
0
0
94
790
1.27
1.13
5.3
3.6
0.00
0.00
estimate
-0.00
20
243
10
180
0.54
1.11
1.4
1.2
224.16
179.58
u/ml
—
10
166
34
456
0.71
1.06
7.3
3.2
4.89
2.02
e6/l
1.21
21
226
161
1449
1.23
1.04
6.3
4.1
0.00
5.21
estimate
0.50
28
312
162
1459
1.23
1.04
6.3
4.2
0.00
0.00
estimate
-0.00
27
287
14
83
1.72
1.03
1.2
1.6
—
—
—
0
0
14
224
0.61
1.02
1.5
2.5
63.04
66.47
g/l
0.71
14
210
20
292
0.66
0.98
5.1
3.4
—
—
—
0
0
0
29
0.00
0.98
0.0
1.2
—
—
—
0
0
0
29
0.00
0.98
0.0
1.1
—
94.40
—
0
5
38
494
0.74
0.98
6.7
3.1
0.92
0.95
e6/l
0.03
25
262
0
30
0.00
0.98
0.0
1.2
—
—
—
0
0
0
31
0.00
0.97
0.0
1.2
—
—
—
0
0
0
31
0.00
0.97
0.0
1.2
—
—
—
0
0
189
1743
1.22
0.92
8.6
4.8
263.17
2549.77
e6/l
—
6
31
6
28
2.16
0.92
1.3
1.2
—
—
—
0
0
158
1434
1.21
0.90
6.3
4.1
0.00
0.00
estimate
-0.00
25
305
108
946
1.22
0.88
4.4
3.4
26.86
32.75
u/l
1.14
103
895
94
812
1.23
0.88
6.1
4.2
0.00
0.00
estimate
-0.00
23
283
14
88
1.62
0.86
1.1
1.7
—
—
—
0
0
24
173
1.42
0.81
4.2
4.2
3.03
1.83
mmol/l
0.57
17
131
38
480
0.76
0.81
1.6
1.6
—
—
—
0
0
8
47
1.72
0.81
1.1
1.8
—
—
—
0
0
0
25
0.00
0.79
0.0
1.2
—
172.87
—
0
25
151
1642
0.84
0.78
3.2
3.0
—
—
—
0
0
7
39
1.81
0.73
1.1
1.4
—
—
—
0
0
27
205
1.35
0.70
4.4
4.0
5.34
5.16
kpa
0.47
27
198
5
95
0.52
0.67
1.8
2.0
2.68
0.80
g/l
—
5
89
8
127
0.62
0.65
1.0
1.3
—
—
—
0
0
6
102
0.58
0.63
1.7
2.0
9.72
10.40
g/l
—
6
95
14
97
1.46
0.60
2.1
1.8
—
—
—
0
0
13
89
1.48
0.59
1.0
1.4
—
—
—
0
0
70
794
0.85
0.57
5.4
3.4
0.32
0.49
e6/l
0.51
57
580
5
87
0.57
0.57
1.2
1.4
—
261.45
—
0
43
5
88
0.56
0.57
1.0
1.5
—
—
—
0
0
155
1656
0.87
0.56
6.2
5.8
7.10
6.66
mmol/l
1.13
148
1573
16
213
0.74
0.52
2.4
2.8
83.29
64.53
ml/min/173m2
—
7
88
14
101
1.40
0.50
1.9
1.9
—
—
—
0
0
102
930
1.14
0.50
2.4
3.4
2.37
2.36
mmol/l
0.23
90
843
11
76
1.46
0.48
1.0
1.1
—
3.31
—
0
8
13
94
1.40
0.46
2.1
1.7
—
—
—
0
0
5
82
0.60
0.46
1.2
1.5
—
—
—
0
0
10
69
1.46
0.45
1.4
1.3
242.00
301.05
ug/g
—
5
42
0
15
0.00
0.41
0.0
1.3
—
1.00
—
0
10
0
18
0.00
0.40
0.0
1.4
—
9.67
—
0
18
0
18
0.00
0.40
0.0
1.2
—
157.81
—
0
18
5
35
1.44
0.39
1.4
1.2
—
—
—
0
0
0
19
0.00
0.39
0.0
1.1
—
1.02
—
0
13
0
19
0.00
0.39
0.0
1.1
—
—
—
0
0
67
605
1.14
0.38
1.7
1.7
1.36
1.42
mg/l
0.06
53
468
9
69
1.31
0.37
1.0
1.2
—
—
—
0
0
155
1472
1.11
0.37
5.4
6.9
12.21
11.77
umol/l
0.04
150
1401
113
1206
0.90
0.36
2.3
2.5
78.83
76.28
nmol/l
0.43
106
1077
6
88
0.68
0.33
1.5
2.2
190.50
203.18
%
—
6
88
165
1579
1.10
0.32
14.0
9.8
4.43
4.06
e9/l
1.25
154
1376
43
483
0.87
0.32
2.0
2.5
9.80
13.06
umol/l
2.87
38
448
7
54
1.30
0.30
1.4
1.4
—
—
—
0
0
148
1414
1.09
0.29
6.5
8.1
1.21
1.21
mmol/l
0.23
137
1230
8
110
0.72
0.29
1.6
1.9
4.16
4.28
g/l
—
8
104
8
110
0.72
0.29
1.6
1.9
7.24
7.26
g/l
—
8
104
8
110
0.72
0.29
1.6
1.9
2.98
3.68
g/l
—
8
104
20
167
1.21
0.29
2.6
1.6
—
—
—
0
0
19
224
0.84
0.26
1.5
1.4
—
—
—
0
0
135
1292
1.08
0.25
16.7
14.6
1.25
1.25
inr
0.03
117
1083
17
201
0.84
0.24
5.3
12.1
26.22
24.89
mmol/l
0.50
17
201
6
83
0.72
0.24
1.0
1.1
—
—
—
0
0
6
85
0.70
0.24
1.0
1.1
—
—
—
0
0
5
38
1.32
0.23
1.2
2.2
9.00
10.08
mmol/l
—
5
38
12
146
0.81
0.22
2.2
2.3
—
—
—
0
0
14
167
0.83
0.22
1.4
3.9
0.76
0.61
%
0.65
14
167
5
42
1.19
0.21
1.0
1.6
—
—
—
0
0
5
42
1.19
0.21
1.0
1.5
—
—
—
0
0
105
1100
0.93
0.21
4.2
4.0
50.08
36.62
ng/l
0.24
71
812
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
7.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
8
103
0.77
0.21
1.6
2.0
2.39
3.03
g/l
—
8
97
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
1514.23
—
0
13
29
323
0.89
0.20
1.5
1.5
—
—
—
0
0
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
7.81
—
0
14
91
866
1.07
0.19
2.8
3.4
564.30
1329.65
ng/l
4.64
79
737
7
59
1.19
0.18
10.3
4.7
20.43
24.31
mg/l
—
7
44
131
1266
1.06
0.17
5.6
7.5
1.21
1.21
mmol/l
0.35
124
1174
6
77
0.77
0.16
2.2
1.9
—
—
—
0
0
10
83
1.21
0.15
1.3
1.4
—
—
—
0
0
12
102
1.18
0.15
3.7
3.1
—
—
—
0
0
38
408
0.92
0.14
4.6
8.7
102.66
104.01
mmol/l
1.16
38
408
16
141
1.14
0.14
1.1
1.0
—
—
—
0
0
210
2068
1.05
0.12
8.1
8.5
94.25
80.88
u/l
0.52
203
1958
96
935
1.04
0.09
4.3
4.0
4.98
8.26
mg/mmol
0.89
71
583
203
2005
1.04
0.08
5.3
4.2
14.73
14.86
pmol/l
0.27
190
1808
13
144
0.90
0.08
1.7
3.1
26.55
24.90
mmol/l
0.79
13
139
5
60
0.83
0.08
1.0
1.2
—
—
—
0
0
11
123
0.89
0.08
1.7
2.2
—
—
—
0
0
7
65
1.08
0.08
1.3
1.3
1.32
0.84
nmol/l
—
7
54
9
86
1.05
0.07
1.0
1.6
—
—
—
0
0
62
630
0.98
0.02
1.5
1.4
0.75
1.79
u/ml
1.69
16
173
71
701
1.02
0.02
2.3
2.2
2.89
2.89
mg/l
0.00
63
606
12
118
1.02
0.00
4.8
5.0
24.74
25.07
mmol/l
0.15
12
111
118
1176
1.01
0.00
2.2
2.1
95.43
96.92
pmol/l
0.13
71
594
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
5
52
0.96
0.00
1.6
2.9
9.22
8.29
pmol/l
—
5
52
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
9.7
—
10.48
—
0
6
0
6
0.00
-0.00
0.0
1.2
—
76.12
—
0
6
0
8
0.00
-0.00
0.0
8.3
—
6.31
—
0
8
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
63
0.95
-0.00
1.5
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
0.23
—
0
6
5
51
0.98
-0.00
1.0
1.7
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint F5_KELARET and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_KELARET | 7.437 [6.07, 9.11] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.092 |
During the follow-up period (1.1.1998 — 31.12.2019), 226 out of 1281 females with F5_KELARET died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| F5_KELARET | 4.05 [3.42, 4.8] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.01 |
During the follow-up period (1.1.1998 — 31.12.2019), 339 out of 2311 males with F5_KELARET died.
Mortality risk
Mortality risk for people of age
years, who have F5_KELARET.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.86% | 0.752% |
| 5 | 4.271% | 4.842% |
| 10 | 9.845% | 11.323% |
| 15 | 17.928% | 20.999% |
| 20 | 28.931% | 33.385% |
Relationships between endpoints
↥Index endpoint: F5_KELARET – Kela-code for behavioural disturbances in mental retardation
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data