epilepsy: A brain disorder characterized by episodes of abnormally increased neuronal discharge resulting in transient episodes of sensory or motor neurological dysfunction, or psychic dysfunction. These episodes may or may not be associated with loss of consciousness or convulsions.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
231 |
4. Check minimum number of eventsNone |
231 |
5. Include endpointsNone |
231 |
6. Filter based on genotype QC (FinnGen only) |
214 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 2
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- G405
- Name in latin
- Ictus epileptici ex usu alcohol
Similar endpoints
↥List of similar endpoints to
Epileptic seizures related to alcohol
based on the number of shared cases.
Similar with more cases:
- Epilepsy
- Alcohol use disorder, Swedish definition
- Alcohol related diseases, tilastokeskus definition
- Alcohol related diseases and deaths, all endpoints
- Episodal and paroxysmal disorders
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3694 | 714 | 2952 |
| Only index persons | 2804 | 567 | 2237 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.07 | 0.02 | 0.08 |
| Only index persons | 0.07 | 0.02 | 0.09 |
| Median age at first event (years) | |||
| Whole population | 51.19 | 51.05 | 51.18 |
| Only index persons | 51.40 | 51.11 | 51.48 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 214 | 44 | 170 |
| Unadjusted period prevalence (%) | 0.07 | 0.02 | 0.08 |
| Median age at first event (years) | 51.86 | 47.35 | 53.03 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 221
- Matched controls
- 2210
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G40.51
ICD-10 Finland
Epileptic seizures related to alcohol
+∞
320.1
221
*
R56.8
ICD-10 Finland
Other and unspecified convulsions
80.2
243.3
158
67
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
44.5
189.6
160
123
F10.31
ICD-10 Finland
Withdrawal symptoms caused by alcohol with seizures
100.6
140.1
74
11
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
28.3
109.2
83
46
G40.9
ICD-10 Finland
Epilepsy, unspecified
31.6
102.6
73
34
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
22.2
93.6
79
54
P15
ICPC
Chronic alcohol abuse
23.7
90.7
73
45
F10.25
ICD-10 Finland
Alcohol dependence continuous use
27.8
75.9
55
26
F10.20
ICD-10 Finland
Alcohol dependence currently independent
27.8
75.9
55
26
F10.40
ICD-10 Finland
Withdrawal symptoms and delirium caused by alcohol without seizures
42.4
75.5
47
14
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
34.1
66.3
44
16
F10.00
ICD-10 Finland
Alcohol-related acute intoxication uncomplicated
28.8
65.2
46
20
N03AX14
ATC
levetiracetam; systemic
23.6
65.0
50
27
F10.39
ICD-10 Finland
Withdrawal symptoms caused by alcohol UNS
33.1
64.3
43
16
F10.09
ICD-10 Finland
Alcohol intoxication UNS
20.2
63.6
53
34
F10.24
ICD-10 Finland
Alcohol depence active use
22.7
60.3
47
26
N07BB01
ATC
disulfiram; oral
12.4
57.7
67
75
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
23.0
52.2
40
21
F10.26
ICD-10 Finland
Alcohol dependence periodic alcoholism
23.0
52.2
40
21
N03AG01
ATC
valproic acid; systemic, rectal
11.9
51.5
60
67
N03AF01
ATC
carbamazepine; oral, rectal
13.1
49.5
53
52
AA1AD
NOMESCO Finland
CT of head and brain
6.3
41.8
133
427
T36
ICD-10 Finland
Poisoning by systemic antibiotics
10.8
39.0
47
54
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
5.8
38.0
124
400
S06.5
ICD-10 Finland
Traumatic subdural haemorrhage
16.7
37.3
33
23
N03AF02
ATC
oxcarbazepine; oral
12.9
36.6
38
35
S01.0
ICD-10 Finland
Open wound of scalp
7.5
36.3
63
112
N05BA02
ATC
chlordiazepoxide; systemic
13.2
34.4
35
31
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
12.5
34.0
36
34
W19
ICD-10 Finland
Unspecified fall
7.0
31.8
57
104
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
5.5
31.8
86
231
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
11.1
31.5
36
38
P16
ICPC
Acute alcohol abuse
13.2
29.8
30
26
N05BA01
ATC
diazepam; systemic, rectal
5.5
28.5
71
176
F10.9
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Unspecified mental and behavioural disorder
39.8
27.4
34
10
F10.2
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Dependence syndrome
23.6
25.3
36
18
F10.49
ICD-10 Finland
Withdrawal symptoms and delirium caused by alcohol without information about seizures
43.1
24.6
30
8
F10.41
ICD-10 Finland
Withdrawal symptoms and delirium caused by alcohol with seizures
76.4
24.4
27
*
G41.9
ICD-10 Finland
Status epilepticus, unspecified
73.2
23.4
26
*
F10.21
ICD-10 Finland
Alcohol dependence currently abstinent, but staying in restrictive environment
22.3
21.5
31
16
F32.9
ICD-10 Finland
Depressive episode, unspecified
5.0
21.2
54
134
F10.06
ICD-10 Finland
Alcohol-related acute intoxication with seizures
85.3
21.1
23
*
G31.2
ICD-10 Finland
Degeneration of nervous system due to alcohol
25.5
21.0
29
13
N06AB04
ATC
citalopram; systemic
4.1
19.9
71
228
S06.0
ICD-10 Finland
Concussion
4.7
19.2
52
135
G40
ICD-10 Finland
Epilepsy
33.4
18.8
24
8
N05AA02
ATC
levomepromazine; systemic
6.6
18.5
32
55
N06AX11
ATC
mirtazapine; oral
3.4
18.3
112
508
F10.30
ICD-10 Finland
Withdrawal symptoms caused by alcohol uncomplicated
17.9
17.5
27
17
X59
ICD-10 Finland
Exposure to unspecified factor
3.7
17.3
75
272
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.6
16.9
74
270
N05CF01
ATC
zopiclone; oral
3.3
16.5
100
445
K70.1
ICD-10 Finland
Alcoholic hepatitis
65.0
16.0
18
*
N05AH04
ATC
quetiapine; oral
3.5
15.4
68
248
A98
ICPC
Health maint/preventive medicine
0.3
15.4
164
2025
S42.2
ICD-10 Finland
Fracture of upper end of humerus
7.4
15.2
23
34
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
14.7
15.1
25
19
K70.3
ICD-10 Finland
Alcoholic cirrhosis of liver
20.2
15.0
22
12
N05CD07
ATC
temazepam; oral
4.1
14.7
46
132
E87.6
ICD-10 Finland
Hypokalaemia
6.6
14.2
24
40
3039X
ICD-9 Finland
Alcohol dependence syndrome, Other and unspecified alcohol dependence
14.9
14.1
23
17
N03AB02
ATC
phenytoin; systemic
16.4
13.4
21
14
F10.03
ICD-10 Finland
Alcohol-related acute intoxication with delirium
30.5
13.2
17
6
Z72.1
ICD-10 Finland
Alcohol use
13.5
12.4
21
17
WX892
NOMESCO Finland
Monitored bed care
4.4
12.4
34
88
N03AX18
ATC
lacosamide; systemic
22.9
12.2
17
8
N05AB01
ATC
dixyrazine; systemic
14.5
12.2
20
15
Y04.9
ICD-10 Finland
Assault by bodily force by unknown person
20.3
11.8
17
9
V03AA01, ,
ATC
9.7
11.6
23
26
NA1AD
NOMESCO Finland
Cervical spine CT examination
4.7
11.1
27
63
N88
ICPC
Epilepsy
45.8
11.0
13
*
W10
ICD-10 Finland
Fall on and from stairs and steps
5.0
11.0
25
55
S06.3
ICD-10 Finland
Focal brain injury
16.6
11.0
17
11
C07AA05
ATC
propranolol; systemic
2.9
10.7
62
260
F10.0
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Acute intoxication
12.9
10.6
18
15
K86.00
ICD-10 Finland
Acute pancreatitis caused by alcohol
11.4
10.5
19
18
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
3.0
10.3
55
220
N03AX09
ATC
lamotrigine; oral
5.3
10.0
21
43
R41.0
ICD-10 Finland
Disorientation, unspecified
8.0
10.0
22
30
C03CA01
ATC
furosemide; systemic
2.6
9.8
74
355
F05.9
ICD-10 Finland
Delirium, unspecified
12.2
9.7
17
15
G40.20
ICD-10 Finland
Complex partial seizures with only alteration of consciousness
18.6
9.5
14
8
WX730
NOMESCO Finland
Conventional respirator
13.2
9.5
16
13
S02.20
ICD-10 Finland
Fracture of nasal bones, closed
13.2
9.5
16
13
K92.0
ICD-10 Finland
Haematemesis
9.3
9.5
19
22
G40.89
ICD-10 Finland
Other epilepsy
31.6
9.5
12
*
K86.08
ICD-10 Finland
Alcohol-induced chronic pancreatitis
31.6
9.5
12
*
F10.4
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Withdrawal state with delirium
104.3
9.5
10
*
N05BA04
ATC
oxazepam; oral
2.6
9.3
69
326
R55
ICD-10 Finland
Syncope and collapse
3.3
9.3
38
129
T90.5
ICD-10 Finland
Sequelae of intracranial injury
12.2
9.2
16
14
G72.8
ICD-10 Finland
Other specified myopathies
10.7
9.2
17
17
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.6
9.1
73
358
G40.12
ICD-10 Finland
Simple partial seizures with secondary generalization
19.6
9.0
13
7
G40.19
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures
19.6
9.0
13
7
G40.6
ICD-10 Finland
Grand mal seizures, unspecified (with or without petit mal)
52.1
8.7
10
*
N07
ICPC
Convulsion/seizure
52.1
8.7
10
*
A06AD11
ATC
lactulose; oral
3.2
8.7
39
140
N06AA12
ATC
doxepin; systemic
4.4
8.5
22
54
G40.50
ICD-10 Finland
Epilepsia partialis continua [Kozhevnikof]
93.5
8.5
9
*
G41.0
ICD-10 Finland
Grand mal status epilepticus
93.5
8.5
9
*
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
3.7
8.4
28
83
183
Kela drug reimbursment
Lamotrigin and topiramate
15.2
8.3
13
9
R40.2
ICD-10 Finland
Coma, unspecified
18.0
8.2
12
7
S62.3
ICD-10 Finland
Fracture of other metacarpal bone
7.7
8.1
18
25
S00.0
ICD-10 Finland
Superficial injury of scalp
8.3
8.0
17
22
S82.6
ICD-10 Finland
Fracture of lateral malleolus
4.3
7.8
21
53
JN3AD
NOMESCO Finland
Abdominal CT examination
2.8
7.8
43
174
WX882
NOMESCO Finland
High dependency care
7.6
7.6
17
24
K70.9
ICD-10 Finland
Alcoholic liver disease, unspecified
26.0
7.6
10
*
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
3.5
7.5
27
84
G40.10
ICD-10 Finland
Simple partial seizures
82.8
7.5
8
*
F10.05
ICD-10 Finland
Alcohol-related acute intoxication with coma
82.8
7.5
8
*
F02.89*G40.9
ICD-10 Finland
Dementia in epilepsy
82.8
7.5
8
*
XA800
NOMESCO Finland
Neuropsychological investigation
4.4
7.4
19
46
TPH07
NOMESCO Finland
Cathetrisation of artery
2.8
7.4
41
166
N05AX08
ATC
risperidone; systemic
3.3
7.4
29
96
2918A
ICD-9 Finland
Alcoholic psychoses, Other specified alcoholic psychosis
+∞
7.3
7
*
SPAT1227
SPAT
Substance abuse rehabilitation
16.4
7.3
11
7
R11
ICD-10 Finland
Nausea and vomiting
3.4
7.3
27
86
K29.2
ICD-10 Finland
Alcoholic gastritis
31.1
7.2
9
*
S00.9
ICD-10 Finland
Superficial injury of head, part unspecified
12.6
7.2
12
10
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
10.5
7.1
13
13
D07BA04
ATC
hydrocortisone and antiseptics; topical
3.3
7.1
28
93
Z2446
NOMESCO Finland
Social worker
3.6
7.1
24
72
Z53.2
ICD-10 Finland
Procedure not carried out because of patient's decision for other and unspecified reasons
8.0
7.0
15
20
K70.0
ICD-10 Finland
Alcoholic fatty liver
14.4
7.0
11
8
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
3.0
7.0
34
128
T74.1
ICD-10 Finland
Physical abuse
9.8
6.9
13
14
SPAT1265
SPAT
Breathalyser
11.5
6.9
12
11
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
3.4
6.8
26
84
S02.30
ICD-10 Finland
Fracture of orbital floor, closed
17.4
6.8
10
6
WX872
NOMESCO Finland
Intensive care
3.4
6.8
25
79
G40.59
ICD-10 Finland
Other special epileptic syndromes
41.4
6.8
8
*
F10.3
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Withdrawal state
23.3
6.7
9
*
N05BA09
ATC
clobazam; oral
23.3
6.7
9
*
P18
ICPC
Medication abuse
23.3
6.7
9
*
N05AD03
ATC
melperone; systemic
12.8
6.7
11
9
SPAT1309
SPAT
Guidance related to psychoactive substances / risk behaviour
6.0
6.6
17
30
X58
ICD-10 Finland
Exposure to other specified factors
2.5
6.6
45
202
R53
ICD-10 Finland
Malaise and fatigue
2.3
6.5
62
324
N03AE01
ATC
clonazepam; systemic
3.7
6.5
21
61
G40.1
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures
71.8
6.5
7
*
F60.30
ICD-10 Finland
Emotionally unstable personality disorder, impulsive
9.7
6.4
12
13
I61.9
ICD-10 Finland
Intracerebral haemorrhage, unspecified
9.7
6.4
12
13
S06.2
ICD-10 Finland
Diffuse brain injury
18.7
6.3
9
5
G62.1
ICD-10 Finland
Alcoholic polyneuropathy
18.7
6.3
9
5
SPD00
NOMESCO Finland
Mucosa borne complete denture
18.7
6.3
9
5
Y91.2
ICD-10 Finland
Severe alcohol intoxication
+∞
6.3
6
*
G40.4
ICD-10 Finland
Other generalized epilepsy and epileptic syndromes
+∞
6.3
6
*
OAB43, ,
SPAT
0.3
6.2
13
439
A28
ICPC
Limited function/disability NOS
2.6
6.1
39
169
N06AB03
ATC
fluoxetine; oral
2.7
6.1
34
138
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
3.1
6.0
26
91
F17.29
ICD-10 Finland
Addiction caused by tobacco UNS
7.6
6.0
13
18
F29
ICD-10 Finland
Unspecified nonorganic psychosis
4.2
6.0
16
40
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
86
303
4.01
21.30
4.5
2.0
2.11
1.61
%
2.90
77
272
144
1941
0.26
19.03
5.0
5.3
1.40
1.36
mmol/l
0.44
135
1821
50
127
4.80
18.93
3.5
1.5
0.51
0.35
mg/l
0.98
39
62
134
1878
0.27
18.82
4.6
4.5
1.42
1.34
mmol/l
0.43
125
1755
147
1941
0.28
17.01
5.3
5.4
4.49
4.54
mmol/l
0.21
139
1832
151
1961
0.27
16.58
6.0
6.0
2.47
2.69
mmol/l
2.08
144
1848
67
262
3.23
13.35
8.5
9.4
0.87
0.87
mmol/l
0.00
55
219
117
650
2.70
11.91
5.3
2.9
60.62
64.22
u/l
0.18
112
611
149
1877
0.37
10.29
5.5
5.1
6.14
6.05
mmol/l
0.31
139
1749
64
284
2.76
9.86
1.7
1.6
1061.49
1231.71
nmol/l
0.86
55
222
69
342
2.48
8.34
2.1
2.1
29.43
29.50
s
0.04
64
335
11
7
16.44
7.30
3.4
2.6
47.18
61.14
umol/l
—
11
7
135
940
2.12
6.76
12.7
8.5
1.18
1.20
mmol/l
3.40
123
826
114
752
2.07
6.52
5.3
4.0
50.08
34.21
u/l
3.19
109
713
50
239
2.41
6.38
2.0
1.9
—
—
—
0
0
156
1859
0.45
6.24
6.6
6.5
39.05
39.70
mmol/mol
0.29
145
1776
51
250
2.35
6.14
2.0
1.8
—
—
—
0
0
38
732
0.42
5.75
2.6
3.1
0.59
0.73
ug/l
1.14
28
453
66
375
2.08
5.48
7.3
3.9
431.44
337.21
ng/l
0.09
56
297
59
325
2.11
5.30
2.2
2.0
—
—
—
0
0
161
1874
0.48
5.15
27.0
15.8
90.57
83.04
ml/min/173m2
3.59
150
1746
6
242
0.23
4.70
2.7
2.1
3.42
3.68
ratio
—
6
195
47
248
2.14
4.67
3.4
3.5
11.95
9.59
umol/l
0.30
40
224
32
146
2.39
4.48
1.8
1.7
—
—
—
0
0
65
969
0.53
4.32
4.2
4.3
22.15
21.80
%
0.07
34
441
35
170
2.26
4.25
6.5
3.0
4.54
4.65
kpa
0.13
35
165
26
115
2.43
3.89
5.1
3.2
23.52
24.24
mmol/l
0.48
26
115
116
864
1.72
3.84
7.4
5.9
33.26
35.74
g/l
3.80
111
822
67
439
1.76
3.43
4.6
3.5
1.02
1.02
kg/l
1.34
51
297
69
456
1.75
3.43
2.9
2.1
2.31
2.92
mg/l
2.04
60
409
25
116
2.30
3.37
4.4
2.5
2.20
1.23
%
1.58
25
116
144
1162
1.69
3.34
5.7
3.9
7856.40
43.68
e6/l
—
5
22
24
113
2.26
3.14
4.8
2.5
0.69
0.62
%
0.51
24
113
14
52
2.81
2.95
1.5
1.6
138.67
288.62
ug/g
—
6
33
56
364
1.72
2.91
2.1
1.8
117647457.51
50160189.66
pmol/l
0.23
51
313
149
1709
0.61
2.90
4.7
4.5
2.01
2.00
mu/l
0.02
139
1577
11
34
3.35
2.77
7.0
3.7
4.93
4.99
kpa
0.09
11
34
24
121
2.10
2.67
1.7
1.6
—
—
—
0
0
173
1899
0.59
2.51
32.8
16.4
29.34
24.96
mg/l
0.94
157
1568
24
127
2.00
2.37
3.0
2.8
1.29
1.75
mmol/l
0.15
15
96
0
50
0.00
1.91
0.0
1.1
—
6.27
—
0
6
119
1370
0.72
1.67
3.8
3.6
14.16
14.74
pmol/l
1.93
113
1257
8
32
2.55
1.61
1.0
1.5
—
—
—
0
0
69
863
0.71
1.57
2.0
2.0
1.36
1.43
mmol/l
0.31
59
735
108
912
1.36
1.46
3.2
2.9
—
—
estimate
—
0
0
18
106
1.76
1.34
2.0
1.4
—
—
—
0
0
118
1023
1.33
1.29
4.7
3.5
0.17
0.00
estimate
0.48
23
208
100
1157
0.75
1.29
3.1
2.8
—
—
—
0
0
30
205
1.54
1.28
6.4
3.4
—
—
—
0
0
6
25
2.44
1.25
5.3
3.8
1.17
1.19
mmol/l
—
6
25
6
25
2.44
1.25
5.3
3.8
101.00
104.60
mmol/l
—
6
25
68
546
1.35
1.24
4.9
3.1
0.35
0.47
e6/l
0.33
55
407
55
434
1.36
1.11
1.8
1.8
1.11
1.49
mg/l
0.53
43
345
5
21
2.41
1.09
2.2
2.6
—
—
—
0
0
13
74
1.80
1.09
2.5
2.0
23.98
24.71
mmol/l
0.25
13
74
7
32
2.23
1.09
5.7
2.1
13.29
10.53
mmol/l
—
7
32
9
49
1.87
1.00
1.1
1.4
—
—
—
0
0
0
29
0.00
0.98
0.0
1.1
—
12.81
—
0
14
0
29
0.00
0.98
0.0
1.1
—
1.03
—
0
9
0
31
0.00
0.97
0.0
1.2
—
0.98
—
0
7
0
32
0.00
0.96
0.0
1.0
—
22.67
—
0
6
9
51
1.80
0.96
1.4
3.1
—
—
—
0
0
6
27
2.26
0.94
2.2
1.3
—
—
—
0
0
8
42
1.94
0.89
1.1
1.2
—
—
—
0
0
13
81
1.64
0.83
3.4
3.4
23.75
25.04
mmol/l
0.77
13
76
115
1032
1.24
0.83
4.8
3.5
0.00
0.00
estimate
-0.00
22
183
66
557
1.26
0.82
5.2
3.5
0.00
0.03
estimate
0.78
22
192
8
47
1.73
0.81
1.5
1.2
—
—
—
0
0
113
1014
1.23
0.81
4.8
3.4
0.00
0.00
estimate
-0.00
23
208
0
25
0.00
0.79
0.0
1.0
—
—
—
0
0
0
26
0.00
0.79
0.0
1.5
—
—
—
0
0
0
26
0.00
0.79
0.0
1.5
—
—
—
0
0
0
27
0.00
0.78
0.0
1.5
—
—
—
0
0
0
27
0.00
0.78
0.0
1.3
—
—
—
0
0
0
27
0.00
0.78
0.0
1.5
—
—
—
0
0
0
27
0.00
0.78
0.0
1.3
—
—
—
0
0
0
27
0.00
0.78
0.0
1.3
—
161.16
—
0
27
0
27
0.00
0.78
0.0
1.5
—
—
—
0
0
0
27
0.00
0.78
0.0
1.5
—
—
—
0
0
6
34
1.79
0.77
7.2
3.3
15.12
11.80
pmol/l
—
6
34
61
713
0.80
0.75
4.2
4.1
20.24
10.33
mg/mmol
0.34
37
484
43
348
1.29
0.74
4.0
2.8
2.00
0.97
e6/l
0.89
23
193
10
60
1.70
0.73
1.5
1.3
—
—
—
0
0
9
56
1.63
0.73
1.8
1.5
—
—
—
0
0
24
317
0.73
0.73
1.3
1.3
22.33
38.97
iu/ml
—
9
99
154
1437
1.24
0.72
9.0
3.6
140.18
57.36
u/l
3.87
149
1372
9
57
1.60
0.72
1.8
3.0
—
—
—
0
0
9
58
1.57
0.70
1.2
1.7
—
—
—
0
0
5
27
1.87
0.69
4.2
4.8
2.08
4.00
nmol/l
—
5
27
7
44
1.61
0.65
1.0
1.4
—
—
—
0
0
89
793
1.20
0.65
6.7
3.8
32.84
35.86
ng/l
0.09
67
584
5
29
1.74
0.64
1.2
1.4
—
—
—
0
0
8
49
1.66
0.63
1.1
1.4
—
—
—
0
0
87
777
1.20
0.62
5.2
3.4
0.00
0.02
estimate
0.68
19
176
5
30
1.68
0.62
1.2
1.5
—
—
—
0
0
5
30
1.68
0.62
1.2
1.5
—
—
—
0
0
0
20
0.00
0.60
0.0
1.1
—
23.02
—
0
10
0
22
0.00
0.59
0.0
1.3
—
—
—
0
0
0
23
0.00
0.58
0.0
1.3
—
—
—
0
0
0
23
0.00
0.58
0.0
1.3
—
—
—
0
0
0
23
0.00
0.58
0.0
1.3
—
—
—
0
0
69
607
1.20
0.57
2.9
4.2
2.32
2.35
mmol/l
0.92
59
552
55
474
1.21
0.56
2.6
2.5
—
—
—
0
0
9
59
1.55
0.55
1.1
1.4
—
—
—
0
0
9
61
1.50
0.54
1.2
1.8
—
—
—
0
0
134
1420
0.86
0.50
3.7
4.2
18.34
10.80
mm/h
4.53
127
1337
7
48
1.47
0.47
1.3
1.2
—
—
—
0
0
7
48
1.47
0.47
1.3
1.2
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
89
821
1.14
0.40
4.2
2.8
213.97
167.97
ug/l
0.97
83
777
0
19
0.00
0.39
0.0
1.2
—
—
—
0
0
38
330
1.18
0.37
4.2
2.9
1.72
1.04
e6/l
0.50
19
176
90
839
1.12
0.33
2.7
2.0
87.18
95.80
pmol/l
1.02
60
460
6
47
1.28
0.32
2.2
1.6
—
—
—
0
0
25
293
0.83
0.32
1.8
1.5
—
—
—
0
0
7
55
1.28
0.30
1.4
1.5
—
—
—
0
0
38
338
1.15
0.29
2.2
3.3
2.44
2.44
mmol/l
0.04
33
298
9
117
0.76
0.28
1.0
1.6
—
—
—
0
0
5
39
1.29
0.23
1.2
1.8
—
—
—
0
0
5
42
1.19
0.21
1.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.9
—
—
—
0
0
0
12
0.00
0.21
0.0
1.9
—
—
—
0
0
0
12
0.00
0.21
0.0
2.3
—
842.67
—
0
12
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
1.00
—
0
6
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
3.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
61
572
1.09
0.20
4.8
2.9
0.00
0.01
estimate
0.50
17
164
5
67
0.74
0.17
1.4
1.9
—
—
—
0
0
8
68
1.18
0.17
1.6
1.3
—
—
—
0
0
7
88
0.79
0.15
1.0
1.0
—
—
—
0
0
7
90
0.77
0.14
3.4
3.2
—
—
—
0
0
14
160
0.87
0.14
1.6
1.4
—
—
—
0
0
38
405
0.93
0.13
1.3
1.3
0.74
0.97
u/ml
0.77
12
122
5
62
0.80
0.08
1.4
1.6
—
—
—
0
0
5
63
0.79
0.08
1.4
1.5
—
—
—
0
0
15
164
0.91
0.08
2.0
2.2
—
—
—
0
0
115
1129
1.04
0.07
8.7
11.9
4.23
4.14
e9/l
0.18
101
985
11
121
0.90
0.06
1.0
1.3
—
55.02
—
0
12
57
555
1.04
0.05
2.4
2.9
354.00
362.39
umol/l
0.21
50
492
16
151
1.06
0.03
2.2
2.6
58.86
68.51
ml/min/173m2
—
7
69
61
617
0.98
0.01
2.6
3.2
1748.21
1098.87
ng/l
0.63
52
522
15
149
1.01
0.00
1.9
2.1
—
—
—
0
0
25
249
1.00
0.00
3.4
5.6
208.76
254.38
u/l
2.00
25
240
13
133
0.98
0.00
1.9
2.5
—
16.56
—
0
13
22
215
1.03
0.00
15.8
7.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
9.7
—
6.35
—
0
6
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
0
6
0.00
0.00
0.0
1.0
—
155.33
—
0
6
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
9.8
—
11.07
—
0
6
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
8
79
1.01
-0.00
1.3
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
5.4
—
125.41
—
0
9
0
8
0.00
-0.00
0.0
1.0
—
1511.50
—
0
8
0
8
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
5
0.00
-0.00
0.0
1.0
—
87.60
—
0
5
0
9
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.6
—
111.66
—
0
5
0
5
0.00
-0.00
0.0
7.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
40.79
—
0
9
0
7
0.00
-0.00
0.0
1.0
—
35.30
—
0
7
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
6
66
0.91
-0.00
1.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
0.93
—
0
7
0
9
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.9
—
147.30
—
0
7
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.6
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint EPISEIZALCO and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| EPISEIZALCO | 9.296 [7.52, 11.49] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.38 |
During the follow-up period (1.1.1998 — 31.12.2019), 231 out of 611 females with EPISEIZALCO died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| EPISEIZALCO | 6.956 [6.12, 7.91] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 1235 out of 2499 males with EPISEIZALCO died.
Mortality risk
Mortality risk for people of age
years, who have EPISEIZALCO.| N-year risk | Females | Males |
|---|---|---|
| 1 | 1.35% | 1.289% |
| 5 | 5.042% | 6.949% |
| 10 | 12.988% | 16.759% |
| 15 | 22.412% | 29.851% |
| 20 | 38.968% | 47.135% |
Relationships between endpoints
↥Index endpoint: EPISEIZALCO – Epileptic seizures related to alcohol
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data