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Deficiency of other B group vitamins

DOID EFO Endpoint Browser PheWeb

E4_VIT_B_DEF

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E53
  • Hospital discharge: ICD-9 — 266
  • Hospital discharge: ICD-8 — 264
  • Cause of death: ICD-10 — E53
  • Cause of death: ICD-9 — 266
  • Cause of death: ICD-8 — 264
  • KELA reimbursements: KELA codes — ANY
  • KELA reimbursements: ICD-10 — E53.8

3 out of 7 registries used, show all original rules.

944

4. Check minimum number of events

None

944

5. Include endpoints

None

944

6. Filter based on genotype QC (FinnGen only)

841

Control definitions (FinnGen only)

Control exclude
E4_NUTRIDEF

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E50-E64
Name in latin
Deficientia aliorum vitaminorum B

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 4877 2712 2110
Only index persons 3881 2214 1667
Unadjusted period prevalence (%)
Whole population 0.07 0.08 0.06
Only index persons 0.07 0.08 0.06
Median age at first event (years)
Whole population 73.31 74.06 72.33
Only index persons 72.05 72.65 71.25

-FinnGen-

Key figures

All Female Male
Number of individuals 841 479 362
Unadjusted period prevalence (%) 0.17 0.17 0.17
Median age at first event (years) 62.43 57.56 68.88

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
865
Matched controls
8650
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
B03BA03
ATC
hydroxocobalamin; parenteral
69.0
307.7
598
272
107
Kela drug reimbursment
Pernicious anaemia
137.0
307.7
447
67
B81
ICPC
Anaemia vit B12/folate deficiency
49.8
307.7
403
149
E53.8
ICD-10 Finland
Deficiency of other specified B group vitamins
805.6
307.7
438
11
K29.4
ICD-10 Finland
Chronic atrophic gastritis
26.8
240.1
173
80
D51.9
ICD-10 Finland
Vitamin B12deficiency anaemia, unspecified
29.6
147.6
100
38
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
5.3
132.7
491
1708
WVA30, ,
SPAT
8.2
119.5
179
266
D51.0
ICD-10 Finland
Vitamin B12deficiency anaemia due to intrinsic factor deficiency
42.6
110.8
67
17
E66.8
ICD-10 Finland
Other obesity
28.1
102.2
70
27
T91
ICPC
Vitamin/nutritional deficiency
20.4
78.7
61
32
E53.9
ICD-10 Finland
Vitamin B deficiency, unspecified
676.5
64.8
63
*
E66.9
ICD-10 Finland
Obesity, unspecified
23.7
61.9
45
20
A55
ICPC
General and Unspecified, Local injection/infiltration
17.8
53.4
44
26
E66.01
ICD-10 Finland
Obesity due to excess calories
7.0
52.8
84
130
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
4.3
51.6
151
404
JDF11
NOMESCO Finland
Laparoscopic gastric bypass
+∞
46.3
44
*
B03BA01
ATC
cyanocobalamin; nasal, systemic
471.5
45.7
45
*
SPAT1256
SPAT
Intramuscular and subcutaneous injection
2.4
35.8
419
2405
RD210, ,
NOMESCO Finland
14.4
34.9
32
23
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.4
34.0
390
2206
601
Kela drug reimbursment
Severe malabsorption of nutrients, mainly fats
11.4
31.3
33
30
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.9
31.2
173
685
D64.9
ICD-10 Finland
Anaemia, unspecified
3.0
30.9
162
622
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.3
30.2
369
2117
-50
ICPC
Medication/prescr/renewal
4.7
30.0
72
163
C10AC01
ATC
colestyramine; oral
6.2
29.8
52
88
K50.0
ICD-10 Finland
Crohn disease of small intestine
8.6
29.3
38
46
376
Kela drug reimbursment
Cyanocobalamin
155.2
28.8
30
*
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
5.3
28.6
59
117
WVA20, ,
SPAT
4.8
26.8
63
140
K50.8
ICD-10 Finland
Other Crohn disease
8.6
26.3
34
41
B03BA02
ATC
cyanocobalamin tannin complex; parenteral
22.7
25.8
37
17
UJF32
NOMESCO Finland
Coloscopy
2.3
25.5
279
1509
UJF30
NOMESCO Finland
Ileoscopy through colon
3.0
25.0
127
476
B80
ICPC
Iron deficiency anaemia
5.7
25.0
48
89
H03AA01
ATC
levothyroxine sodium; systemic
2.3
24.9
253
1324
JN3BD
NOMESCO Finland
Extensive abdominal CT
3.0
24.0
117
428
SPAT1254
SPAT
Administration of medicine
2.5
23.2
172
780
E66.00
ICD-10 Finland
Metabolic syndrome
6.3
23.0
39
64
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.0
22.1
458
3107
E55.9
ICD-10 Finland
Vitamin D deficiency, unspecified
32.1
21.6
28
9
Z01.8
ICD-10 Finland
Other specified special examinations
2.2
21.3
228
1208
ZX114, ,
SPAT
7.2
21.3
32
46
A07EA06
ATC
budesonide; oral, local oral
4.2
21.0
57
142
A02BC02
ATC
pantoprazole; systemic
2.1
20.7
618
4719
TPH04
NOMESCO Finland
Cathetrisation of vein
2.2
20.3
229
1237
R4190
NOMESCO Finland
Nutritional therapy
4.6
20.1
49
112
JN3AD
NOMESCO Finland
Abdominal CT examination
2.5
20.1
140
615
B82
ICPC
Anaemia other/unspecified
4.4
20.0
51
121
N03AX16
ATC
[U] pregabalin
2.1
19.7
230
1257
K50.9
ICD-10 Finland
Crohn disease, unspecified
7.0
19.6
30
44
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.5
19.6
146
661
L04AX01
ATC
azathioprine; systemic
4.1
19.6
56
145
D51.8
ICD-10 Finland
Other vitamin B12deficiency anaemias
47.2
19.3
23
5
D50.8
ICD-10 Finland
Other iron deficiency anaemias
6.9
19.2
30
45
JF1AB
NOMESCO Finland
Passage examination of small bowell with X-ray
8.3
18.8
25
31
2662A
ICD-9 Finland
Deficiency of B-complex components, Other B-complex deficiencies[HYPOVITAMINOSIS B12]
+∞
18.8
18
*
215
Kela drug reimbursment
Diabetes, non-insulin-treated
2.1
18.4
224
1239
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.3
18.1
167
828
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
3.7
17.9
58
164
D51
ICD-10 Finland
Vitamin B12deficiency anaemia
18.5
17.9
27
15
C03CA01
ATC
furosemide; systemic
1.9
17.6
345
2246
A50
ICPC
General and Unspecified, Medication/prescr/renewal
3.8
17.4
55
153
N02AX02
ATC
tramadol; systemic, rectal
1.9
17.3
397
2713
A10AE04
ATC
insulin glargine; parenteral
2.6
17.1
104
426
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.1
17.1
215
1201
UJF92
NOMESCO Finland
Capsular endoscopy
5.7
17.1
32
58
K29.7
ICD-10 Finland
Gastritis, unspecified
3.9
17.0
51
137
D13.1
ICD-10 Finland
Benign neoplasm: Stomach
5.2
16.6
34
67
A10AB05
ATC
insulin aspart; parenteral
2.9
16.4
83
309
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.1
16.2
173
906
JFB00
NOMESCO Finland
Partial resection of small intestine
5.7
15.6
29
52
QBJ30
NOMESCO Finland
Correction of abdominal apron
86.7
15.6
17
*
208
Kela drug reimbursment
Ulcerative colitis and Crohn's disease
3.6
15.6
53
155
N06AX16
ATC
venlafaxine; oral
2.3
15.3
130
621
R42
ICD-10 Finland
Dizziness and giddiness
1.9
14.9
232
1388
103
Kela drug reimbursment
Diabetes, insulin-treated
1.9
14.9
252
1549
R11
ICD-10 Finland
Nausea and vomiting
2.5
14.8
99
424
N06AX11
ATC
mirtazapine; oral
1.8
14.8
311
2044
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
3.5
14.4
50
148
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.0
14.1
173
951
R53
ICD-10 Finland
Malaise and fatigue
1.9
14.0
247
1532
WZC00
NOMESCO Finland
Treatment plan or consultation
1.8
13.8
310
2068
A01
ICPC
Pain general/multiple sites
2.3
13.7
107
491
326
Kela drug reimbursment
Adalimumab, golimumab, infliximab and ustekinumab (intestinal diseases)
12.3
13.6
24
20
H02AB06
ATC
prednisolone; systemic
1.7
13.6
420
3062
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
4.1
13.5
37
93
N06AB04
ATC
citalopram; systemic
1.9
13.1
195
1142
SPAT1262
SPAT
Handing over of treatment supplies
2.0
13.1
156
846
J01MA12
ATC
levofloxacin; systemic
1.9
13.1
181
1035
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.7
13.1
310
2094
L28
ICPC
Limited function/disability (L)
1.9
12.9
196
1156
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.0
12.7
167
939
K29.3
ICD-10 Finland
Chronic superficial gastritis
3.5
12.6
44
131
F02.89*E53.8
ICD-10 Finland
Dementia due to vitamin B12 deficiency
+∞
12.5
12
*
E66.2
ICD-10 Finland
Extreme obesity with alveolar hypoventilation
131.8
12.5
13
*
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.9
12.4
168
953
AA1AD
NOMESCO Finland
CT of head and brain
1.7
12.3
277
1839
A07AA02
ATC
nystatin; oral
2.7
12.2
66
254
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
3.5
12.1
42
125
JKA21
NOMESCO Finland
Laparoscopic cholecystectomy
2.2
12.0
105
505
J01MA02
ATC
ciprofloxacin; systemic
1.7
12.0
351
2498
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.8
11.9
228
1441
T82
ICPC
Obesity
4.0
11.8
33
84
P01AB01
ATC
metronidazole; oral, rectal
1.7
11.8
342
2425
E03.89
ICD-10 Finland
Other specified hypothyroidism
3.4
11.8
43
132
K08.3
ICD-10 Finland
Retained dental root
2.5
11.7
77
327
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.2
11.7
106
518
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
2.1
11.6
126
659
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
1.8
11.6
220
1385
K56.6
ICD-10 Finland
Other and unspecified intestinal obstruction
3.5
11.5
40
119
JDF01
NOMESCO Finland
Laparoscopic gastroplasty
+∞
11.5
11
*
G32.0*E53.8
ICD-10 Finland
Subacute combined degeneration of the spinal cord in case of vitamin B12 deficiency
+∞
11.5
11
*
A04
ICPC
Weakness/tiredness general
1.9
11.4
154
872
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.8
11.3
191
1160
A10BA02
ATC
metformin; oral
1.7
11.3
249
1635
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
3.9
11.3
33
87
K80.2
ICD-10 Finland
Calculus of gallbladder without cholecystitis
2.1
11.3
115
588
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.5
11.2
75
321
104
Kela drug reimbursment
Thyroid insufficiency
2.4
11.1
78
341
A06AD11
ATC
lactulose; oral
1.9
11.1
164
956
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.3
11.0
91
428
T90
ICPC
Diabetes non-insulin dependent
1.8
10.9
202
1260
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
2.8
10.9
54
199
K56.5
ICD-10 Finland
Intestinal adhesions [bands] with obstruction
4.4
10.8
27
63
R07.4
ICD-10 Finland
Chest pain, unspecified
1.7
10.7
248
1647
WX110
NOMESCO Finland
Infiltration anesthesia
1.6
10.7
560
4565
K29.5
ICD-10 Finland
Chronic gastritis, unspecified
3.5
10.7
36
105
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
2.5
10.6
67
279
E0000UV, ,
ATC
1.6
10.5
345
2506
E66.0
ICD-10 Finland
Obesity due to excess calories
111.3
10.4
11
*
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.6
10.4
361
2658
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
2.3
10.3
82
379
JF1CG
NOMESCO Finland
Extensive MRI of small bowel
10.8
10.3
19
18
E61.1
ICD-10 Finland
Iron deficiency
4.8
10.3
23
49
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.0
10.3
118
630
WX002
NOMESCO Finland
Sedation and analgesia
1.8
10.2
172
1041
Z3226
NOMESCO Finland
Physiotherapist
1.8
10.2
165
988
JDW98
NOMESCO Finland
Other transluminal endoscopic operation on stomach or duodenum
5.4
10.1
20
38
N17.9
ICD-10 Finland
Acute renal failure, unspecified
2.9
10.1
48
173
K10.3
ICD-10 Finland
Alveolitis of jaws
3.0
10.0
43
146
SPAT1216
SPAT
Assessment of functional ability
1.9
10.0
150
877
SPAT1172
SPAT
Guidance concerning hydration
3.8
9.9
30
81
N06AA09
ATC
amitriptyline; systemic
2.2
9.9
92
453
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
2.3
9.8
72
322
R06AE07
ATC
cetirizine; oral
1.6
9.8
340
2494
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
4.2
9.8
26
64
K43.9
ICD-10 Finland
Other and unspecified ventral hernia without obstruction or gangrene
3.0
9.7
44
154
L17
ICPC
Foot/toe symptom/complaint
1.7
9.7
253
1727
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
3.0
9.6
42
144
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.9
9.6
124
690
E86
ICD-10 Finland
Volume depletion
3.4
9.5
34
103
E000001, ,
ATC
1.8
9.5
165
1008
Z2445
NOMESCO Finland
Psychologist
3.3
9.4
35
109
E61.2
ICD-10 Finland
Magnesium deficiency
+∞
9.4
9
*
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
2.0
9.4
109
584
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
2.3
9.3
74
342
M79.6
ICD-10 Finland
Pain in limb
1.6
9.3
363
2726
J01FF01
ATC
clindamycin; systemic
1.7
9.1
222
1486
N05AH04
ATC
quetiapine; oral
1.8
9.0
149
894
JN4AD
NOMESCO Finland
Body CT examination
2.0
9.0
104
555
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
2.0
9.0
103
549
D07AA02
ATC
hydrocortisone; topical
1.9
9.0
120
674
J45.9
ICD-10 Finland
Asthma, unspecified
1.8
9.0
164
1015
UJD02
NOMESCO Finland
Gastroscopy
2.6
9.0
53
214
SFC01
NOMESCO Finland
Additional procedure necessary for restorative treatment
1.7
8.9
207
1367
D07AB08
ATC
desonide; topical
2.0
8.9
98
514
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.6
8.9
314
2297
XW000
NOMESCO Finland
Bone marrow biopsy
2.8
8.9
44
162
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
2.2
8.9
77
369
R06.0
ICD-10 Finland
Dyspnoea
1.6
8.9
243
1674
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
2.6
8.9
51
203
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
4.7
8.9
20
43
T36
ICD-10 Finland
Poisoning by systemic antibiotics
3.0
8.8
39
135
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
2.0
8.8
99
525
N06AB03
ATC
fluoxetine; oral
2.0
8.7
105
569
S29
ICPC
Skin symptom/complaint other
1.7
8.7
168
1056
SPAT1222
SPAT
Counselling/guidance promoting independent living
1.8
8.7
143
858
ZY010
NOMESCO Finland
Hospital outpatient
2.7
8.6
47
182
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.8
8.6
149
906
K50.1
ICD-10 Finland
Crohn disease of large intestine
7.0
8.6
20
29
ZXD05
NOMESCO Finland
Urgent procedure
1.6
8.6
261
1843
A10BH05
ATC
linagliptin; oral
2.5
8.6
54
225
N30.0
ICD-10 Finland
Acute cystitis
1.8
8.5
153
941
SPAT1229
SPAT
Assessment of need for aid
2.2
8.5
75
362
TAB00
NOMESCO Finland
Lumbar puncture
2.6
8.5
47
184
B01AB05
ATC
enoxaparin; parenteral
1.6
8.5
264
1874
A28
ICPC
Limited function/disability NOS
1.7
8.4
183
1186
D11
ICPC
Diarrhoea
2.0
8.4
95
504
EB1AA
NOMESCO Finland
Intraoral radiographic dental examination
1.5
8.4
408
3195
XF402
NOMESCO Finland
ECG with work load test
2.0
8.4
93
490
R25.1
ICD-10 Finland
Tremor, unspecified
3.1
8.4
34
112
M25.5
ICD-10 Finland
Pain in joint
1.6
8.4
262
1861
E66.1
ICD-10 Finland
Drug-induced obesity
+∞
8.3
8
*
E53.1
ICD-10 Finland
Pyridoxine deficiency
+∞
8.3
8
*
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.9
8.3
108
600
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.5
8.3
346
2618
SFA30
NOMESCO Finland
Three-surface restoration
1.5
8.3
324
2417
N06AX21
ATC
duloxetine; oral
2.0
8.3
98
528
SGA02
NOMESCO Finland
Opening and preparing the root canals
1.9
8.3
101
550
EBA00
NOMESCO Finland
Extraction of tooth
1.6
8.2
272
1954
-55
ICPC
Local injection/infiltration
7.6
8.2
18
24
J01DB01
ATC
cefalexin; oral
1.6
8.2
669
5854
A10BG03
ATC
pioglitazone; oral
3.6
8.2
26
73
WX408
NOMESCO Finland
General anesthesy, balanced
1.6
8.1
210
1422
JF1BD
NOMESCO Finland
Very extensive small bowel CT
10.2
8.0
15
15
SPAT1295
SPAT
Other function in accordance with physical therapy nomenclature
2.5
8.0
50
207
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.6
8.0
219
1504
D07BA04
ATC
hydrocortisone and antiseptics; topical
2.1
8.0
80
406
A05AA02
ATC
ursodeoxycholic acid; oral
4.3
8.0
20
47
R60.0
ICD-10 Finland
Localized oedema
1.8
7.9
114
657
L20.9
ICD-10 Finland
Atopic dermatitis, unspecified
2.9
7.8
35
122
N02BE01
ATC
paracetamol; systemic, rectal
1.8
7.8
745
6730
K85.9
ICD-10 Finland
Acute pancreatitis, unspecified
3.7
7.8
24
66
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.8
7.8
132
798
R20.2
ICD-10 Finland
Paraesthesia of skin
2.2
7.7
64
301
EBA15
NOMESCO Finland
Extraction of multiple teeth
2.9
7.7
35
123
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
2.9
7.7
35
123
Z53.2
ICD-10 Finland
Procedure not carried out because of patient's decision for other and unspecified reasons
4.4
7.7
19
44
E66
ICD-10 Finland
Obesity
2.9
7.7
36
129
N03AX09
ATC
lamotrigine; oral
2.7
7.6
40
152
A07EC02
ATC
mesalazine; oral, rectal
2.5
7.6
49
206
SPAT1263
SPAT
Sampling
1.5
7.6
323
2445
C07AB07
ATC
bisoprolol; oral
1.5
7.6
425
3403
NA2BG
NOMESCO Finland
Thoracal spine MRI examination with high intensity magnet
3.4
7.6
27
82
R50.9
ICD-10 Finland
Fever, unspecified
1.8
7.6
132
804
F45.4
ICD-10 Finland
Persistent somatoform pain disorder
3.9
7.6
22
58
D09
ICPC
Nausea
2.7
7.5
41
159
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
2.8
7.5
37
136
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.1
7.5
75
380
A10BH01
ATC
sitagliptin; oral
2.0
7.5
81
423
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.6
7.5
232
1638
M54.5
ICD-10 Finland
Low back pain
1.5
7.5
282
2080
SFA40
NOMESCO Finland
Restoration involving the entire crown of the tooth
1.6
7.4
173
1139
XG410
NOMESCO Finland
Flow-volume spirometry
2.7
7.4
38
143
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.6
7.4
242
1728
R51.80
ICD-10 Finland
Headache
1.8
7.4
124
747
SPAT1240
SPAT
Therapeutic discussion
2.1
7.4
72
362
D06
ICPC
Abdominal pain localized other
2.1
7.4
73
369
SGB10
NOMESCO Finland
Root filling of tooth with one root canal
1.9
7.3
95
528
R60.9
ICD-10 Finland
Oedema, unspecified
2.3
7.3
55
249
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
2.1
7.3
67
329
A10BB12
ATC
glimepiride; oral
2.1
7.3
69
343
Z01.1
ICD-10 Finland
Examination of ears and hearing
1.8
7.3
125
758
R4110
NOMESCO Finland
Physiotherapy
1.6
7.3
229
1621
K90.0
ICD-10 Finland
Coeliac disease
3.1
7.3
30
100
ZX120
NOMESCO Finland
Intravenous
2.0
7.2
85
457
212
Kela drug reimbursment
Gout
3.7
7.2
22
60
R19.8
ICD-10 Finland
Other specified symptoms and signs involving the digestive system and abdomen
4.5
7.2
17
38
J46
ICD-10 Finland
Status asthmaticus
3.2
7.2
28
90
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.1
7.2
69
345
X59
ICD-10 Finland
Exposure to unspecified factor
1.7
7.1
151
969
K59.1
ICD-10 Finland
Functional diarrhoea
2.3
7.1
54
245
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
2.5
7.1
42
170
K04.5
ICD-10 Finland
Chronic apical periodontitis
1.6
7.1
208
1447
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
2.4
7.1
50
220
XF400
NOMESCO Finland
ECG with 12 standard connections
1.7
7.1
141
891
SAA03
NOMESCO Finland
Extended examination of mouth
1.5
7.0
283
2109
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.6
7.0
160
1046
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
2.7
7.0
38
147
F32.11
ICD-10 Finland
Moderate depressive episode with somatic syndrome
3.3
7.0
26
81
A06AC01
ATC
ispaghula (psylla seeds); oral
1.5
7.0
231
1650
K02.1
ICD-10 Finland
Caries of dentine
1.5
7.0
427
3457
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.5
7.0
238
1713
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.6
7.0
185
1257
SPAT1125
SPAT
Stoma care and guidance
3.8
6.9
21
57
JFB33
NOMESCO Finland
Other resection comprising small intestine and colon
13.9
6.9
11
8
JAH01
NOMESCO Finland
Laparoscopy
2.5
6.9
44
185
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
2.5
6.9
43
179
P03
ICPC
Feeling depressed
2.1
6.9
67
337
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.5
6.8
251
1833
A10AE05
ATC
insulin detemir; parenteral
2.4
6.8
46
198
M04AA01
ATC
allopurinol; systemic
1.7
6.8
118
717
H04.10
ICD-10 Finland
Dry eye syndrome
1.8
6.8
103
602
J01EA01
ATC
trimethoprim; systemic
1.5
6.8
228
1635
Z98.0
ICD-10 Finland
Intestinal bypass and anastomosis status
16.8
6.8
10
6
JDA05
NOMESCO Finland
Endoscopic polypectomy in stomach or pylorus
16.8
6.8
10
6
Z3231
NOMESCO Finland
Registered nurse
1.5
6.7
223
1592
JL5BG
NOMESCO Finland
MRI examinaiton of bile and pancreas ducts with high intesity magnet
3.3
6.7
25
78
R03AC02
ATC
salbutamol; inhalant
1.5
6.7
431
3512
SPAT1234
SPAT
Support of social functional capacity
2.2
6.7
53
245
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
1.8
6.7
106
627
A02BC05
ATC
esomeprazole; systemic
1.5
6.7
321
2476
SPAT1255
SPAT
Intravenous administration of medicine
2.2
6.7
58
279
N03AX12
ATC
[U] gabapentin; oral
1.7
6.6
132
833
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
2.5
6.6
40
164
B50
ICPC
Blood and Immunity, Medication/prescr/renewal
12.4
6.6
11
9
WX302
NOMESCO Finland
Thoracal epidural anesthesy
2.4
6.6
44
189
E83.51
ICD-10 Finland
Hypocalcemia
8.8
6.6
13
15
N02AA05
ATC
oxycodone; systemic
1.6
6.6
167
1122
C03DA01
ATC
spironolactone; oral
1.8
6.5
110
662
B81
ICD-10 Finland
Other intestinal helminthiases, not elsewhere classified
70.4
6.4
7
*
SPAT1211
SPAT
Application of soft bandage
2.0
6.4
72
381
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
1.8
6.4
90
513
DNB20
NOMESCO Finland
Endoscopic ethmoidectomy
3.1
6.4
25
81
D50
ICD-10 Finland
Iron deficiency anaemia
3.1
6.4
25
81
H02AB07
ATC
prednisone; oral
1.7
6.3
119
739
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
1.8
6.3
88
500
M35.7
ICD-10 Finland
Hypermobility syndrome
5.6
6.3
17
31
F03
ICD-10 Finland
Unspecified dementia
2.1
6.3
55
265
Z71.8
ICD-10 Finland
Other specified counselling
1.5
6.3
256
1905
D10
ICPC
Vomiting
2.4
6.3
43
187
SPA00
NOMESCO Finland
Changing form of teeth in prepation for prosthodontic work
2.5
6.3
38
156
E53
ICD-10 Finland
Deficiency of other B group vitamins
+∞
6.3
6
*
E53.0
ICD-10 Finland
Riboflavin deficiency
+∞
6.3
6
*
WZC30
NOMESCO Finland
Teaching
1.7
6.2
129
822
K91.2
ICD-10 Finland
Postsurgical malabsorption, not elsewhere classified
26.9
6.2
8
*
Q79.6
ICD-10 Finland
Ehlers-Danlos syndrome
26.9
6.2
8
*
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
1.9
6.2
78
429
A10AC01
ATC
insulin (human); parenteral
2.0
6.2
69
364
WX402
NOMESCO Finland
General anaesthesia
1.6
6.2
157
1053
J45
ICD-10 Finland
Asthma
1.9
6.2
82
459
R07.0
ICD-10 Finland
Pain in throat
2.2
6.2
52
247
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.6
6.1
179
1240
JF1AD
NOMESCO Finland
Small bowel CT
7.7
6.1
13
17
D53.1
ICD-10 Finland
Other megaloblastic anaemias, not elsewhere classified
12.6
6.1
10
8
G43.0
ICD-10 Finland
Migraine without aura [common migraine]
2.3
6.1
44
196
N03AE01
ATC
clonazepam; systemic
2.2
6.1
48
222
310
Kela drug reimbursment
Orlistat, sibutramine and other major and expensive medicines used to treat obesity
10.1
6.0
11
11
S97
ICPC
Chronic ulcer skin
2.0
6.0
60
304
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
2.2
6.0
48
223
R10.0
ICD-10 Finland
Acute abdomen
2.8
6.0
29
106
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
2.8
6.0
29
106

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
603
3265
3.80
73.39
3.6
2.1
81.44
94.76
pmol/l
7.71
402
1689
336
1357
3.41
63.58
2.2
1.7
1131.92
1148.41
nmol/l
0.11
268
1018
427
2009
3.22
62.28
3.3
2.2
2.98
2.91
mg/l
0.24
375
1730
310
1228
3.38
59.99
3.4
2.5
11.96
12.73
umol/l
1.05
302
1142
294
1146
3.37
58.15
3.3
2.4
2.36
2.27
g/l
1.68
283
1060
273
1054
3.32
54.36
3.3
2.5
21.00
22.41
%
0.87
263
982
430
2220
2.86
50.15
2.5
1.7
17.75
20.55
nmol/l
3.80
376
1871
245
954
3.19
47.30
1.5
1.2
—
—
—
0
0
325
1541
2.78
43.25
2.4
1.7
32331292.79
19953312.38
pmol/l
0.15
266
1273
271
1186
2.87
41.82
4.3
3.2
0.80
0.82
mmol/l
2.83
257
1115
233
939
3.03
41.80
5.5
5.1
1.04
1.03
mmol/l
0.32
223
854
526
3239
2.59
40.00
7.1
4.7
34.38
35.40
g/l
3.97
498
3016
566
3699
2.53
36.49
9.8
6.9
1.20
1.21
mmol/l
2.29
504
3170
527
3348
2.47
35.93
5.5
3.0
116.95
125.85
ug/l
0.48
496
3089
503
3206
2.36
32.91
4.1
2.4
73.87
79.10
nmol/l
3.52
453
2862
211
912
2.74
32.36
3.2
2.4
1.76
1.78
%
0.15
183
814
403
2365
2.32
31.64
7.9
5.9
—
—
—
0
0
391
2273
2.31
31.31
3.5
2.5
53.23
100.03
u/l
0.74
368
2122
508
3329
2.27
30.06
8.6
6.1
8.76
8.94
%
0.72
481
3095
545
3688
2.29
29.67
8.5
5.9
1.79
1.90
e9/l
0.95
491
3256
507
3332
2.26
29.62
9.5
6.1
1.21
1.21
mmol/l
1.19
480
3058
506
3323
2.26
29.61
8.6
6.1
0.65
0.67
%
0.35
477
3080
31
28
11.45
29.47
2.1
1.1
119.79
132.26
nmol/l
0.63
31
28
506
3328
2.25
29.43
8.5
6.0
2.88
2.81
%
0.25
478
3088
505
3333
2.24
28.93
8.4
6.0
58.71
57.96
%
0.72
484
3159
536
3629
2.25
28.76
8.5
5.9
0.04
0.04
e9/l
0.19
467
3112
509
3390
2.22
28.24
8.6
6.1
26.24
27.03
%
0.83
487
3190
546
3749
2.24
27.95
8.6
6.1
0.19
0.19
e9/l
0.08
485
3275
553
3821
2.24
27.81
8.5
6.4
11.24
11.83
umol/l
0.68
529
3652
531
3615
2.21
27.64
8.5
5.9
0.59
0.59
e9/l
0.12
461
3098
159
654
2.75
26.42
3.0
2.2
0.19
0.21
g/l
2.82
151
602
164
692
2.69
25.89
3.4
2.4
68.07
67.74
e9/l
0.04
130
530
185
856
2.48
24.00
3.9
2.3
163.29
120.05
ug/g
1.24
153
679
504
3485
2.07
23.61
17.1
16.7
1.26
1.30
inr
0.84
437
2935
561
4060
2.09
22.90
12.1
9.3
4.48
4.14
e9/l
1.97
498
3539
155
678
2.57
22.55
2.2
2.1
394.50
391.11
nmol/l
0.06
141
633
279
1580
2.13
22.16
1.4
1.3
2.04
1.70
u/ml
0.12
77
423
574
4219
2.07
22.06
7.4
4.8
6.94
6.68
mmol/l
1.42
560
4021
29
36
8.30
21.86
1.9
1.3
13.59
28.57
umol/l
1.55
29
31
146
641
2.54
20.99
6.2
6.4
9.41
10.29
mmol/l
0.75
137
611
243
1361
2.09
19.48
1.9
1.5
2.73
2.45
g/l
1.02
129
821
169
832
2.28
18.68
3.3
2.5
7.69
8.14
umol/l
0.13
153
734
181
919
2.23
18.56
1.5
1.3
544.39
503.12
titre
0.10
41
218
670
5401
2.07
17.58
13.0
8.0
87.35
78.97
u/l
2.73
646
5107
606
4723
1.95
17.46
6.6
4.9
6.14
3008.31
e6/l
—
7
85
351
2311
1.87
17.17
3.9
3.1
44.22
33.96
u/l
0.50
330
2188
348
2289
1.87
17.05
2.4
2.2
193.11
234.10
u/l
0.22
337
2173
329
2130
1.88
16.91
5.1
4.2
—
—
—
0
0
119
523
2.48
16.91
2.9
3.0
10.65
10.71
g/l
0.05
107
480
91
351
2.78
16.82
1.7
1.7
1.37
1.50
g/l
0.68
74
318
156
781
2.22
16.41
1.6
1.3
—
—
—
0
0
139
672
2.27
15.88
5.3
4.1
7.36
7.35
ph
0.28
111
482
117
537
2.36
15.05
3.2
2.4
—
—
—
0
0
98
415
2.54
15.02
3.8
3.3
24.06
24.05
mmol/l
0.01
98
410
603
4817
1.83
14.58
6.3
4.7
—
2.81
—
0
10
132
648
2.22
14.47
3.2
2.9
66.55
66.43
g/l
0.07
118
599
63
216
3.07
14.38
1.4
1.5
287.45
279.23
ug/g
0.10
33
129
95
407
2.50
14.19
2.3
1.7
1.20
1.49
g/l
0.53
86
372
339
2308
1.77
14.17
3.3
2.4
—
—
—
0
0
121
578
2.27
14.16
3.8
3.6
84.80
88.78
ng/l
0.22
96
507
332
2262
1.76
13.74
5.9
3.9
7.40
7.40
ph
0.03
260
1641
153
819
2.05
13.37
1.9
1.7
—
—
—
0
0
50
156
3.34
13.33
1.2
1.2
114.00
92.38
titre
—
5
21
369
2615
1.72
13.11
3.5
3.5
2.32
2.35
mmol/l
5.98
330
2364
68
258
2.78
12.94
4.3
3.8
53.22
72.09
mg/l
0.37
56
221
143
757
2.07
12.85
4.3
3.4
7.37
7.38
ph
1.12
80
456
340
2375
1.71
12.60
4.2
3.3
—
—
—
0
0
394
2864
1.69
12.58
5.0
4.0
51.73
85.30
ng/l
0.47
302
2103
101
470
2.30
12.53
5.1
3.8
7.41
7.42
ph
0.73
84
391
67
258
2.73
12.40
4.4
3.8
45.37
59.20
mg/l
0.40
55
222
344
2419
1.70
12.39
4.4
3.5
79.97
108.86
e6/l
0.27
273
1875
32
77
4.28
12.33
1.6
1.6
19.84
41.38
ng/l
0.78
32
77
138
735
2.04
12.16
4.3
3.3
1.54
1.72
mmol/l
0.19
120
620
128
669
2.07
11.86
1.5
1.5
—
—
—
0
0
61
229
2.79
11.85
4.4
3.6
1.71
2.83
ratio
1.06
34
134
154
866
1.95
11.61
3.0
3.2
4.79
4.75
e9/l
0.02
130
740
84
374
2.38
11.51
2.8
2.4
—
—
—
0
0
264
1758
1.72
11.43
5.4
3.9
87.70
88.18
%
0.10
257
1720
206
1286
1.79
11.14
1.5
1.3
24.59
32.81
iu/ml
0.85
64
413
122
649
2.02
10.74
3.8
2.4
40.73
34.16
u/l
0.44
105
541
40
126
3.28
10.53
1.4
1.2
—
—
—
0
0
255
1719
1.69
10.39
3.2
2.4
—
—
—
0
0
85
398
2.26
10.37
4.1
3.5
4.12
4.51
pmol/l
3.16
75
351
61
249
2.56
10.07
2.0
1.5
0.22
0.33
mg/l
1.10
31
111
367
2729
1.60
10.02
5.3
4.0
121.54
130.35
e6/l
0.06
278
1961
262
1795
1.66
9.96
2.9
2.7
347.98
342.37
umol/l
0.31
227
1569
90
439
2.17
9.94
1.2
1.3
—
—
—
0
0
115
616
2.00
9.90
9.9
7.9
—
—
—
0
0
222
1458
1.70
9.90
3.9
3.0
537.65
529.20
mosm/kgh2o
0.22
189
1279
33
96
3.53
9.82
2.8
1.7
31.85
32.50
pg
0.38
33
96
54
211
2.66
9.73
1.3
1.2
1.14
2.53
u/ml
—
7
22
59
241
2.55
9.73
5.3
4.4
24.39
25.00
mmol/l
0.72
52
228
293
2077
1.62
9.67
4.1
3.3
0.48
0.42
e6/l
0.17
226
1546
58
241
2.51
9.24
1.4
1.2
—
—
—
0
0
72
330
2.29
9.24
4.9
4.0
—
—
—
0
0
53
212
2.60
9.13
1.3
1.2
1.54
10.32
u/ml
1.06
12
37
628
5359
1.63
9.10
6.4
4.3
15.23
14.81
pmol/l
3.58
565
4887
168
1043
1.76
9.09
2.5
2.0
—
—
—
0
0
464
3713
1.54
8.76
5.3
4.0
0.00
0.00
estimate
0.50
118
783
143
856
1.80
8.74
1.6
1.6
—
—
—
0
0
314
2308
1.57
8.70
4.3
4.0
11.81
9.02
mg/mmol
0.38
202
1427
164
1024
1.74
8.67
1.8
1.7
—
—
—
0
0
468
3757
1.54
8.67
5.3
4.0
0.00
4.34
estimate
0.80
121
807
229
1564
1.63
8.63
2.0
1.7
1.26
1.32
mg/l
0.10
178
1227
319
2361
1.56
8.53
3.7
3.3
1735.00
1605.48
ng/l
0.21
279
2047
34
111
3.15
8.48
2.4
1.8
0.97
0.86
%
0.55
28
78
50
206
2.51
8.13
3.1
2.5
1.57
1.66
mg/l
0.32
45
182
536
4471
1.52
8.01
5.1
3.2
61.96
47.49
u/l
1.20
515
4205
315
2352
1.53
7.97
3.5
3.2
7.32
7.22
mmol/l
0.14
265
1970
466
3785
1.50
7.84
5.3
4.0
0.00
0.40
estimate
0.52
111
769
35
124
2.90
7.61
3.1
2.4
8.54
7.75
pmol/l
0.19
35
124
29
92
3.23
7.59
1.1
1.3
—
—
—
0
0
289
2138
1.53
7.55
8.1
6.1
—
—
—
0
0
60
278
2.24
7.53
1.8
2.2
233.00
412.81
ug/l
0.50
60
266
97
538
1.90
7.52
1.3
1.2
—
—
—
0
0
412
3288
1.48
7.41
3.5
2.7
—
—
estimate
—
0
0
239
1703
1.56
7.38
3.5
2.8
5.05
5.65
e6/l
0.40
213
1563
83
440
1.98
7.34
1.3
1.4
—
—
—
0
0
706
6316
1.64
7.28
7.9
5.4
1.95
1.94
mu/l
0.04
640
5796
131
805
1.74
7.27
3.7
4.2
12.04
24.73
ug/l
0.61
113
668
300
2254
1.51
7.22
3.7
3.3
61.31
48.36
mg/l
0.34
203
1430
170
1124
1.64
7.17
2.4
2.0
30.06
29.35
s
0.90
161
1091
62
298
2.16
7.12
1.9
1.9
17.12
6.89
iu/ml
0.57
18
70
177
1184
1.62
7.12
3.6
3.1
3.01
2.43
e6/l
0.29
87
602
35
129
2.79
7.10
5.7
3.1
2.99
2.54
mmol/l
0.39
23
88
58
272
2.21
7.08
3.6
2.0
10.31
10.49
g/l
0.11
49
242
391
3113
1.47
6.98
18.5
11.1
0.00
0.00
e9/l
0.53
315
2543
53
241
2.28
6.96
3.4
3.3
259.50
247.35
mg/l
0.06
30
91
177
1192
1.61
6.91
1.5
1.3
10.17
12.43
u/ml
0.15
57
451
264
1950
1.51
6.82
4.2
3.3
—
0.00
estimate
—
0
14
324
2496
1.48
6.80
5.1
3.6
—
0.83
—
0
6
104
615
1.79
6.57
6.2
4.6
0.04
0.17
%
0.91
23
169
36
141
2.62
6.52
2.3
2.4
167.26
110.00
ug/min
0.30
24
86
38
153
2.55
6.51
2.2
3.4
139.76
374.28
u/ml
0.60
32
143
372
2965
1.45
6.45
4.2
3.6
6.18
6.24
ph
0.53
223
1678
40
168
2.45
6.29
1.3
1.2
20.38
53.22
u/ml
—
6
20
133
853
1.66
6.28
9.7
7.7
7.41
7.42
ph
0.15
80
506
35
138
2.60
6.27
1.3
1.5
—
—
—
0
0
739
6754
1.65
6.23
29.2
16.6
25.86
25.72
mg/l
0.03
671
5582
183
1271
1.56
6.21
3.3
3.0
0.93
1.08
e6/l
0.37
97
693
132
852
1.65
6.07
9.7
7.6
0.51
1.03
mmol/l
0.60
114
695
36
147
2.51
6.01
6.4
3.1
—
—
—
0
0
100
602
1.75
5.95
5.9
4.3
0.18
0.13
%
0.26
22
179
36
149
2.48
5.85
1.3
1.3
69.13
61.31
mmol/l
0.53
30
124
41
181
2.33
5.80
1.1
1.1
13.27
5.84
eliau/ml
—
7
20
113
709
1.68
5.79
10.3
8.5
117.38
119.98
g/l
0.66
113
697
103
634
1.71
5.66
5.8
4.2
1.68
0.87
%
1.09
25
211
752
6943
1.64
5.61
33.0
19.7
139.29
139.65
mmol/l
2.78
740
6804
27
99
2.78
5.57
1.8
1.8
0.79
0.86
g/l
0.08
22
78
258
1963
1.45
5.56
3.7
3.1
0.29
0.05
—
7
60
212
1554
1.48
5.53
6.7
4.6
—
—
—
0
0
752
6952
1.63
5.47
33.2
19.9
3.97
3.98
mmol/l
0.33
737
6796
26
95
2.79
5.40
1.1
1.1
—
—
—
0
0
16
43
3.77
5.38
1.0
1.2
—
—
—
0
0
98
606
1.70
5.30
5.5
4.2
1.00
0.52
%
1.19
26
196
202
1479
1.48
5.27
4.3
4.0
116.94
339.76
ng/l
2.26
162
1186
23
81
2.89
5.12
2.0
1.9
90.70
89.85
%
0.37
23
81
130
877
1.57
4.97
1.8
1.4
—
—
—
0
0
23
83
2.82
4.91
1.1
1.1
111.80
60.70
iu/ml
—
5
10
41
196
2.15
4.84
1.6
2.6
56.14
59.45
%
0.41
41
191
63
353
1.85
4.78
1.4
1.2
—
—
—
0
0
63
356
1.83
4.66
2.4
2.2
0.00
0.01
estimate
0.50
18
106
60
337
1.84
4.53
2.1
2.0
—
—
—
0
0
47
244
1.98
4.48
2.1
1.8
19.83
20.89
s
1.19
41
221
106
700
1.59
4.44
2.4
2.1
0.05
0.02
estimate
0.22
19
135
13
28
4.70
4.38
1.0
1.0
—
—
—
0
0
71
425
1.73
4.34
1.3
1.3
—
40.94
—
0
33
18
61
2.99
4.30
1.8
1.2
0.45
0.39
g/l
0.30
13
45
690
6358
1.42
4.14
8.4
6.3
40.51
39.25
mmol/mol
2.28
628
5925
34
162
2.14
4.08
1.5
1.7
—
—
—
0
0
22
87
2.57
3.99
1.2
1.2
954.25
339.07
pmol/l
0.46
16
77
25
107
2.38
3.86
3.0
3.3
4.61
4.43
e9/l
0.15
25
107
22
89
2.51
3.82
1.0
1.1
6.70
1.71
eliau/ml
—
6
37
338
2831
1.32
3.73
5.6
4.0
0.11
0.05
estimate
0.72
93
652
39
204
1.95
3.68
2.4
3.4
0.53
2.24
index
2.75
21
109
203
1579
1.37
3.67
3.3
3.0
2.44
2.46
mmol/l
0.85
173
1412
58
348
1.71
3.55
4.9
5.8
1.59
1.54
%
0.14
58
331
44
244
1.85
3.51
1.8
1.6
10.13
9.29
u/ml
—
7
48
258
2099
1.33
3.45
5.8
4.0
0.00
0.01
estimate
0.99
103
727
736
6921
1.43
3.41
25.4
14.8
—
—
—
0
0
23
101
2.31
3.38
1.3
1.4
114.90
161.15
au/ml
—
8
30
13
39
3.37
3.23
1.2
1.4
4.03
6.85
u/l
1.39
13
32
22
97
2.30
3.22
1.2
1.2
—
0.12
nmol/l
—
0
5
22
97
2.30
3.22
1.2
1.2
0.55
19.26
nmol/l
0.50
22
91
10
24
4.20
3.20
1.0
1.0
—
—
—
0
0
756
7161
1.44
3.19
36.6
21.8
82.70
78.50
umol/l
2.02
746
7069
24
112
2.18
3.09
1.2
1.4
—
—
—
0
0
23
106
2.20
3.05
1.1
1.1
27.14
12.52
au/ml
—
5
28
34
182
1.90
3.04
2.5
1.9
3.52
4.22
iu/l
0.33
13
71
334
2856
1.28
2.99
2.5
2.2
—
—
—
0
0
17
69
2.49
2.97
1.1
1.0
0.03
0.77
u/ml
—
7
20
85
588
1.49
2.93
5.5
3.6
1.22
1.23
mmol/l
0.40
78
507
29
149
1.98
2.93
3.7
3.1
59.83
58.89
%
0.12
29
149
18
76
2.40
2.91
1.1
1.1
0.66
4.68
u/ml
—
7
27
10
27
3.73
2.88
1.0
1.1
1361.70
1547.56
miu/ml
—
10
27
8
18
4.48
2.80
1.0
1.2
—
—
—
0
0
10
28
3.60
2.79
1.0
1.1
166.10
152.41
iu/ml
—
10
28
22
104
2.14
2.76
1.1
1.0
1.12
3.89
u/ml
—
10
49
90
639
1.46
2.73
3.4
2.5
0.27
0.57
e6/l
1.05
85
614
49
304
1.65
2.71
3.4
3.2
2240.56
1410.54
u/ml
0.15
43
260
12
40
3.03
2.70
2.3
1.7
—
—
—
0
0
8
19
4.24
2.68
1.9
2.0
0.59
0.62
mmol/l
—
8
19
693
6519
1.32
2.67
6.0
5.1
6.04
5.92
mmol/l
1.13
627
5934
16
67
2.41
2.64
1.1
1.2
—
—
—
0
0
18
80
2.28
2.62
1.1
1.1
—
—
—
0
0
206
1683
1.29
2.60
4.8
4.1
1.02
1.91
kg/l
0.50
153
1130
35
200
1.78
2.59
1.8
2.2
13.51
12.40
mg/l
0.33
35
185
23
114
2.05
2.58
1.1
1.1
0.99
2.28
u/ml
0.55
14
59
743
7070
1.36
2.57
18.8
11.9
24.49
24.87
u/l
0.23
726
6860
18
81
2.25
2.55
1.1
1.0
0.35
2.92
u/ml
—
7
34
5
7
7.18
2.55
1.2
1.6
51.60
72.00
ug/l
—
5
7
52
333
1.60
2.55
2.0
1.8
4.53
2.22
ug/l
0.50
46
298
13
50
2.62
2.54
1.6
3.0
16.58
15.71
%
0.46
13
50
14
56
2.52
2.54
2.4
2.8
—
—
—
0
0
26
137
1.93
2.48
2.0
1.3
—
—
—
0
0
24
123
1.98
2.47
2.1
1.7
—
—
—
0
0
20
96
2.11
2.44
1.2
1.0
0.08
0.98
u/ml
—
9
38
49
313
1.60
2.44
4.8
6.2
0.91
0.88
%
0.19
49
295
18
83
2.19
2.42
2.3
1.3
—
—
—
0
0
32
536
0.58
2.40
1.4
1.4
—
—
—
0
0
24
125
1.95
2.37
3.2
1.6
—
—
—
0
0
16
72
2.25
2.28
2.3
2.6
—
—
—
0
0
13
53
2.47
2.28
1.2
1.2
—
—
—
0
0
6
13
4.64
2.27
1.0
1.0
—
—
—
0
0
21
106
2.01
2.27
3.1
2.8
—
—
—
0
0
7
18
3.91
2.25
1.0
1.1
—
—
—
0
0
57
386
1.51
2.22
15.5
10.1
15.39
15.68
%
0.34
57
372
82
597
1.41
2.21
2.5
3.2
263.84
248.33
ng/l
0.08
73
549
10
35
2.88
2.21
3.3
4.7
68.40
101.25
umol/l
—
5
24
6
14
4.31
2.15
1.3
1.9
—
—
—
0
0
213
2506
0.80
2.11
3.1
3.2
—
—
—
0
0
239
2036
1.24
2.09
5.3
3.5
0.04
0.07
estimate
0.17
90
615
14
62
2.28
2.08
1.3
1.2
—
—
—
0
0
17
82
2.09
2.08
1.6
1.2
—
—
—
0
0
21
110
1.93
2.07
1.4
1.2
268.36
257.19
u/ml
0.08
14
58
66
468
1.44
2.06
1.2
1.2
218.55
136.08
u/ml
1.27
28
200
13
56
2.34
2.05
1.2
1.2
—
—
—
0
0
6
15
4.02
2.04
1.0
1.1
—
—
—
0
0
17
83
2.07
2.02
1.2
1.2
0.15
0.19
nmol/l
1.09
12
60
17
83
2.07
2.02
1.2
1.2
—
—
nmol/l
—
0
0
26
148
1.78
2.00
1.3
1.2
11.30
10.73
u/l
0.08
21
116
759
7300
1.32
1.98
43.7
25.1
256.67
248.18
e9/l
2.35
743
7150
759
7301
1.32
1.97
43.5
25.0
91.64
91.47
fl
0.39
748
7212
18
91
2.00
1.96
1.2
1.0
0.10
1.35
u/ml
—
9
43
759
7303
1.32
1.95
44.7
25.5
38.50
39.78
%
7.86
748
7209
759
7303
1.32
1.95
43.4
25.0
30.26
30.38
pg
0.87
748
7213
759
7303
1.32
1.95
43.6
25.1
4.28
4.42
e12/l
10.22
742
7132
759
7304
1.32
1.94
43.7
25.2
7.02
6.81
e9/l
1.67
742
7131
9
33
2.74
1.93
1.3
1.7
—
—
—
0
0
759
7307
1.32
1.91
44.1
25.3
128.30
133.14
g/l
15.33
749
7215
29
174
1.69
1.88
1.3
1.3
—
—
—
0
0
7
22
3.20
1.88
2.0
2.1
34.14
29.82
%
—
7
22
65
470
1.41
1.85
8.6
7.4
23.56
24.35
mmol/l
0.87
65
454
32
199
1.63
1.82
1.2
1.2
—
—
—
0
0
5
12
4.18
1.82
1.2
1.1
—
—
—
0
0
5
12
4.18
1.82
1.0
1.3
—
—
—
0
0
15
75
2.02
1.70
1.2
1.1
—
—
—
0
0
74
556
1.36
1.70
7.2
3.8
—
—
—
0
0
17
91
1.89
1.61
1.8
1.5
—
—
—
0
0
17
91
1.89
1.61
1.8
1.5
—
—
—
0
0
17
91
1.89
1.61
1.8
1.5
—
—
—
0
0
17
91
1.89
1.61
1.8
1.5
—
—
—
0
0
6
21
2.87
1.50
1.8
2.2
5.67
4.43
%
—
6
21
6
21
2.87
1.50
2.3
1.5
83.50
103.62
nmol/24h
—
6
21
12
58
2.08
1.49
1.2
1.1
131.33
105.48
pmol/l
0.65
12
58
11
52
2.13
1.45
1.6
2.8
9.34
8.04
mmol/l
0.48
11
52
657
6278
1.19
1.44
4.6
4.3
1.36
1.23
mmol/l
3.84
600
5734
699
6721
1.21
1.41
6.1
5.8
2.46
2.67
mmol/l
8.01
647
6198
19
111
1.73
1.40
2.5
1.6
—
—
—
0
0
42
298
1.43
1.38
1.5
1.3
25.50
27.77
iu/l
0.17
36
256
18
104
1.75
1.37
1.2
1.1
—
—
—
0
0
687
6604
1.20
1.34
5.5
5.1
4.36
4.61
mmol/l
8.50
641
6125
683
6566
1.19
1.31
5.4
5.0
1.43
1.50
mmol/l
3.55
631
6043
74
581
1.30
1.31
3.6
2.7
6.02
6.07
ph
0.26
52
411
11
55
2.01
1.27
1.0
1.7
282.40
312.09
mu/l
—
5
44
35
244
1.45
1.27
1.1
1.1
—
—
—
0
0
6
25
2.41
1.24
1.0
1.2
—
—
—
0
0
15
85
1.78
1.23
1.3
1.2
—
—
—
0
0
12
63
1.92
1.23
2.0
2.7
364.75
925.71
mg
1.57
12
63
12
63
1.92
1.23
1.3
1.7
—
—
—
0
0
306
2782
1.15
1.23
2.1
1.9
1.46
1.31
mmol/l
1.38
265
2326
26
172
1.53
1.21
1.1
1.1
—
—
—
0
0
13
71
1.84
1.20
1.1
1.1
—
—
—
0
0
78
625
1.27
1.19
1.3
1.4
—
—
—
0
0
15
86
1.76
1.19
1.3
1.3
13234.63
45174.27
e6/l
—
8
48
25
165
1.53
1.18
2.4
2.0
1074.81
4157.43
u/l
—
9
61
8
38
2.12
1.18
1.1
2.6
1506.87
817.66
u/ml
—
8
38
78
628
1.27
1.16
2.9
2.5
4.00
7.26
ug/l
2.71
64
547
5
20
2.51
1.15
4.0
1.5
—
—
—
0
0
12
65
1.86
1.14
1.5
1.6
10.26
10.80
%
0.19
12
65
12
65
1.86
1.14
2.7
2.0
—
—
—
0
0
7
30
2.34
1.12
1.4
1.8
2.26
7.91
nmol/l
—
7
24
7
30
2.34
1.12
1.0
1.1
—
—
—
0
0
10
51
1.97
1.11
2.1
2.1
42.67
39.27
%
—
10
51
27
185
1.47
1.09
2.0
1.3
—
—
—
0
0
7
32
2.20
1.08
1.1
1.1
—
—
—
0
0
7
32
2.20
1.08
1.1
1.1
—
—
—
0
0
7
32
2.20
1.08
1.1
1.1
—
—
—
0
0
25
169
1.49
1.08
2.1
1.3
—
—
—
0
0
15
89
1.70
1.08
1.6
1.3
—
—
—
0
0
27
186
1.47
1.07
2.5
1.3
—
—
—
0
0
27
186
1.47
1.07
2.0
1.3
—
—
—
0
0
13
74
1.77
1.07
1.2
1.1
—
—
—
0
0
44
333
1.34
1.04
1.3
1.2
—
—
—
0
0
9
46
1.97
1.03
1.7
1.8
16.29
13.39
umol/l
—
9
40
23
155
1.50
1.02
1.3
1.5
10.40
14.14
e6/l
0.15
15
119
14
83
1.70
1.02
1.1
1.3
—
—
—
0
0
16
99
1.63
1.00
1.3
1.3
1302.70
1299.64
e6/l
—
10
66
23
157
1.48
0.97
1.3
1.5
2511.06
123.38
e6/l
0.48
16
125
13
77
1.70
0.95
3.2
2.6
—
—
—
0
0
26
184
1.43
0.92
3.7
3.5
0.87
0.87
nmol/l
0.00
17
150
26
185
1.42
0.90
2.2
1.3
—
—
—
0
0
41
316
1.31
0.88
2.0
3.0
—
—
—
0
0
24
169
1.43
0.88
1.2
1.2
—
—
—
0
0
8
43
1.87
0.87
1.4
1.1
—
—
—
0
0
18
121
1.50
0.83
1.2
1.5
36.23
31.35
g/l
1.17
18
108
15
97
1.56
0.81
1.2
1.4
—
—
—
0
0
15
99
1.52
0.76
1.2
1.1
—
—
—
0
0
107
934
1.17
0.76
1.3
1.3
—
—
—
0
0
37
466
0.78
0.72
1.4
1.8
3.18
3.55
mmol/l
1.15
22
338
5
27
1.86
0.68
1.0
1.9
41.82
40.43
g/l
—
5
27
5
92
0.54
0.67
1.8
1.6
—
—
—
0
0
13
191
0.68
0.67
1.4
1.3
—
—
—
0
0
7
44
1.60
0.65
1.1
1.3
—
—
—
0
0
5
30
1.67
0.61
1.2
1.2
510.60
629.72
u/l
—
5
25
19
139
1.38
0.60
1.8
1.9
53.58
42.13
nmol/l
0.59
19
133
0
23
0.00
0.58
0.0
1.2
—
138.28
—
0
18
5
90
0.55
0.56
1.8
1.4
—
—
—
0
0
76
668
1.15
0.53
1.6
1.5
—
—
—
0
0
9
64
1.41
0.51
2.2
2.5
—
57.88
—
0
6
11
75
1.47
0.51
1.2
1.0
—
—
—
0
0
13
92
1.42
0.50
1.5
1.2
3.75
5.39
u/ml
—
8
41
6
41
1.47
0.50
2.2
2.0
121.67
94.05
ng/l
—
6
41
6
41
1.47
0.50
5.5
2.6
—
—
—
0
0
198
1851
1.09
0.48
1.6
1.4
—
—
—
0
0
7
46
1.53
0.48
1.1
1.2
—
—
—
0
0
11
76
1.45
0.48
1.3
1.2
—
—
—
0
0
15
199
0.75
0.47
1.1
1.2
1.53
1.59
g/l
0.35
15
199
8
56
1.43
0.42
1.6
1.1
—
—
—
0
0
16
122
1.32
0.42
1.0
1.2
—
—
—
0
0
10
70
1.43
0.42
1.2
1.8
—
—
—
0
0
8
59
1.36
0.41
1.1
1.2
—
—
—
0
0
5
35
1.43
0.39
2.4
1.8
41.48
54.99
ug/l
—
5
35
55
487
1.14
0.38
1.6
1.6
—
—
—
0
0
10
72
1.39
0.37
1.0
1.1
—
—
—
0
0
23
189
1.22
0.36
5.9
5.2
—
—
—
0
0
118
1268
0.92
0.35
3.1
3.3
0.85
0.81
ug/l
0.11
85
866
546
5577
0.94
0.35
35.0
21.7
329.17
331.53
g/l
6.55
541
5535
16
128
1.25
0.32
2.0
1.4
—
—
—
0
0
13
101
1.29
0.32
1.2
1.6
—
—
—
0
0
17
208
0.81
0.31
1.4
1.2
0.83
0.90
g/l
0.79
17
208
8
66
1.21
0.26
1.1
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
2.0
—
2.23
—
0
11
0
11
0.00
0.21
0.0
1.1
—
280.57
—
0
6
221
2139
1.04
0.21
5.9
5.8
2.22
2.89
ug/l
1.23
191
1898
0
14
0.00
0.20
0.0
1.0
—
0.43
—
0
9
12
99
1.22
0.19
2.3
2.9
—
—
—
0
0
11
90
1.23
0.19
1.1
1.4
7.36
6.55
mmol/l
0.51
11
85
62
582
1.07
0.17
1.6
1.4
—
—
—
0
0
21
186
1.13
0.17
2.0
1.6
14739.92
12252.47
e6/l
0.08
13
128
67
708
0.94
0.15
1.6
1.6
—
—
—
0
0
29
317
0.91
0.15
1.7
1.8
—
—
—
0
0
12
103
1.17
0.13
1.3
1.8
—
—
—
0
0
5
46
1.09
0.09
1.8
1.4
87.60
79.78
umol/l
—
5
46
8
76
1.05
0.07
3.1
2.4
—
—
—
0
0
9
87
1.03
0.07
1.1
1.1
—
—
—
0
0
9
88
1.02
0.07
1.1
1.1
—
—
—
0
0
14
152
0.92
0.06
8.7
9.2
11.79
11.35
mmol/l
0.30
14
141
14
152
0.92
0.06
8.7
9.2
104.93
105.28
mmol/l
0.09
14
141
31
298
1.04
0.04
1.1
1.1
—
—
—
0
0
45
451
1.00
0.00
2.6
2.3
11.88
12.87
nmol/l
0.27
38
401
22
221
1.00
0.00
9.7
10.9
—
—
—
0
0
0
5
0.00
-0.00
0.0
5.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
5.6
—
0.08
—
0
5
7
76
0.92
-0.00
5.4
3.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
9.54
—
0
5
0
5
0.00
-0.00
0.0
6.8
—
0.21
—
0
5
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
0.03
—
0
5
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint E4_VIT_B_DEF and mortality.

Females

Parameter HR [95% CI] p-value
E4_VIT_B_DEF 1.558 [1.34, 1.81] < 0.001
Birth year 0.995 [0.99, 1.0] 0.248

During the follow-up period (1.1.1998 — 31.12.2019), 919 out of 2076 females with E4_VIT_B_DEF died.

Males

Parameter HR [95% CI] p-value
E4_VIT_B_DEF 1.736 [1.45, 2.08] < 0.001
Birth year 0.983 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 800 out of 1606 males with E4_VIT_B_DEF died.

Mortality risk

Mortality risk for people of age

years, who have E4_VIT_B_DEF.

N-year risk Females Males
1 0.131% 0.299%
5 0.919% 1.861%
10 2.566% 4.57%
15 4.72% 8.204%
20 8.144% 13.297%

Relationships between endpoints

↥

Index endpoint: E4_VIT_B_DEF – Deficiency of other B group vitamins

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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