ascorbic acid deficiency: A condition due to a dietary deficiency of ascorbic acid (vitamin C), characterized by malaise, lethargy, and weakness. As the disease progresses, joints, muscles, and subcutaneous tissues may become the sites of hemorrhage. Ascorbic acid deficiency frequently develops into scurvy in young children fed unsupplemented cow's milk exclusively during their first year. It develops also commonly in chronic alcoholism. (Cecil Textbook of Medicine, 19th ed, p1177)
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
184 |
4. Check minimum number of eventsNone |
184 |
5. Include endpointsNone |
184 |
6. Filter based on genotype QC (FinnGen only) |
164 |
Control definitions (FinnGen only)
- Control exclude
- E4_NUTRIDEF
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E50-E64
- Name in latin
- Deficientia vitamini A
Similar endpoints
↥List of similar endpoints to
Vitamin A deficiency
based on the number of shared cases.
Similar with more cases:
- Vitamin deficiency, wide
- Vitamin deficiency
- Other nutritional deficiencies
- Endocrine, nutritional and metabolic diseases
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1746 | 1131 | 591 |
| Only index persons | 1302 | 892 | 410 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.03 | 0.02 |
| Only index persons | 0.03 | 0.03 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 65.53 | 63.81 | 68.82 |
| Only index persons | 58.80 | 56.29 | 64.25 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 164 | 108 | 56 |
| Unadjusted period prevalence (%) | 0.03 | 0.04 | 0.03 |
| Median age at first event (years) | 52.26 | 43.60 | 68.97 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 170
- Matched controls
- 1700
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E50.9
ICD-10 Finland
Vitamin A deficiency, unspecified
+∞
98.9
85
*
E50.0
ICD-10 Finland
Vitamin A deficiency with conjunctival xerosis
+∞
36.8
34
*
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
8.6
30.2
45
68
H03BB01
ATC
carbimazole; oral
11.5
28.9
33
35
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
15.6
18.3
30
23
D64.9
ICD-10 Finland
Anaemia, unspecified
5.2
17.7
43
103
H03AA01
ATC
levothyroxine sodium; systemic
3.9
15.7
66
239
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
13.7
14.6
25
21
E50.7
ICD-10 Finland
Other ocular manifestations of vitamin A deficiency
+∞
13.7
13
*
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
11.4
13.0
24
24
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
3.9
11.9
41
127
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
5.6
11.4
23
46
E66.8
ICD-10 Finland
Other obesity
46.6
11.1
13
*
A10AB05
ATC
insulin aspart; parenteral
4.6
11.0
29
73
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.0
10.6
69
315
H06.2*E05.9
ICD-10 Finland
Dysthyroid exophthalmos
116.9
10.5
11
*
I50.9
ICD-10 Finland
Heart failure, unspecified
3.1
8.9
46
182
E66.00
ICD-10 Finland
Metabolic syndrome
12.6
8.2
14
12
E66.01
ICD-10 Finland
Obesity due to excess calories
7.2
8.2
19
29
UJF32
NOMESCO Finland
Coloscopy
2.6
7.6
57
274
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.8
7.4
45
194
A10AC01
ATC
insulin (human); parenteral
3.5
7.4
27
86
26000
ICD-8 Finland
Vitamin A deficiency, Night blindness
+∞
7.3
7
*
E89.00
ICD-10 Finland
Postirradiation hypothyroidism
31.5
7.2
9
*
104
Kela drug reimbursment
Thyroid insufficiency
3.6
6.9
24
74
SPAT1262
SPAT
Handing over of treatment supplies
2.9
6.8
36
143
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.3
6.5
74
425
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
6.4
6.5
16
27
RD210, ,
NOMESCO Finland
18.9
6.3
9
5
E66.9
ICD-10 Finland
Obesity, unspecified
18.9
6.3
9
5
A10AE04
ATC
insulin glargine; parenteral
3.3
6.3
26
89
E50.1
ICD-10 Finland
Vitamin A deficiency with Bitot spot and conjunctival xerosis
+∞
6.3
6
*
R50.9
ICD-10 Finland
Fever, unspecified
2.7
6.2
37
157
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
71
363
2.64
8.48
4.0
2.0
3.33
2.82
mg/l
1.01
66
319
46
232
2.35
5.32
2.4
1.8
—
—
—
0
0
90
598
2.07
5.16
4.8
4.5
34.35
35.77
g/l
1.65
85
567
17
53
3.45
4.76
1.6
2.0
—
—
—
0
0
15
43
3.73
4.73
2.1
2.1
15.20
5.01
iu/l
—
7
20
50
276
2.15
4.60
2.0
1.7
408.27
462.62
pmol/l
0.95
41
226
15
45
3.56
4.44
1.5
1.0
—
—
—
0
0
44
234
2.19
4.42
2.0
1.7
1034.74
1169.77
nmol/l
0.42
36
178
32
153
2.34
4.12
2.0
3.8
268.69
237.66
u/l
0.35
32
145
78
533
1.86
3.78
10.4
4.0
51.74
141.17
ng/l
0.38
56
367
15
51
3.13
3.68
1.8
1.8
—
—
—
0
0
23
102
2.45
3.48
2.2
1.5
—
—
—
0
0
91
672
1.76
3.27
10.3
6.4
1.22
1.21
mmol/l
0.39
74
572
102
780
1.77
3.23
10.8
9.9
4.76
4.08
e9/l
1.34
94
682
11
32
3.60
2.96
1.4
1.4
—
—
—
0
0
83
618
1.67
2.74
8.6
5.4
1.23
1.22
mmol/l
0.55
72
574
6
10
6.17
2.72
1.7
1.4
—
—
—
0
0
94
727
1.66
2.65
8.2
6.1
10.02
10.74
umol/l
0.38
88
699
21
104
2.16
2.49
1.9
3.4
66.15
77.44
ng/l
0.45
13
94
84
644
1.60
2.37
4.4
2.6
—
—
estimate
—
0
0
110
906
1.61
2.25
4.4
3.2
72.00
48.13
u/l
0.96
104
856
12
48
2.61
2.24
2.9
2.7
—
—
—
0
0
80
613
1.58
2.22
2.6
2.1
114.87
94.59
pmol/l
2.48
55
323
40
259
1.71
2.16
1.8
1.6
—
—
—
0
0
11
43
2.66
2.12
1.2
1.4
—
—
—
0
0
20
104
2.05
2.11
20.0
2.4
4.68
8.32
ug/l
0.51
14
91
12
51
2.46
2.00
1.7
1.4
—
9.26
—
0
13
6
16
3.85
1.95
1.2
1.2
—
—
—
0
0
9
34
2.74
1.89
2.0
2.6
3.67
3.74
g/l
—
9
34
58
426
1.55
1.88
2.1
1.7
16.29
21.92
nmol/l
2.55
52
356
66
506
1.50
1.73
3.2
3.1
2.29
2.36
mmol/l
3.65
59
456
7
25
2.87
1.67
2.7
1.5
—
—
—
0
0
120
1046
1.50
1.60
9.1
4.4
15.52
14.70
pmol/l
2.60
111
943
44
314
1.54
1.60
2.0
1.8
1.02
1.48
mg/l
0.76
36
255
46
332
1.53
1.59
4.0
2.2
—
—
—
0
0
118
1028
1.48
1.56
6.5
4.4
15.15
11.72
mm/h
1.61
111
944
26
164
1.69
1.55
2.8
1.7
—
—
—
0
0
6
22
2.79
1.44
1.3
1.2
—
—
—
0
0
17
279
0.57
1.42
1.3
1.5
—
—
—
0
0
45
331
1.49
1.42
2.0
2.9
361.08
329.95
umol/l
0.88
39
286
9
41
2.26
1.39
1.1
1.2
—
—
—
0
0
14
76
1.92
1.34
18.5
6.8
25.69
24.64
mmol/l
0.30
14
76
10
48
2.15
1.30
1.3
1.4
—
—
—
0
0
14
77
1.89
1.30
1.9
1.7
—
—
—
0
0
53
414
1.41
1.21
4.4
3.4
0.00
0.00
estimate
-0.00
14
118
6
26
2.35
1.19
1.7
1.3
8.22
5.97
pmol/l
—
6
26
74
617
1.35
1.12
3.7
2.5
74.34
77.62
nmol/l
0.55
68
554
26
179
1.53
1.11
1.7
2.3
—
—
—
0
0
12
67
1.85
1.07
1.8
1.3
—
—
—
0
0
23
156
1.55
1.05
3.1
1.8
—
—
—
0
0
52
419
1.35
0.97
5.9
3.9
9.31
9.80
mg/mmol
0.05
34
270
10
55
1.87
0.94
1.5
1.5
—
—
—
0
0
6
29
2.11
0.90
1.7
1.3
—
—
—
0
0
6
30
2.04
0.88
1.0
1.3
—
—
—
0
0
23
164
1.47
0.85
6.4
5.0
34.06
32.82
%
0.16
18
102
47
381
1.32
0.84
1.5
1.2
0.48
1.48
u/ml
—
10
111
34
262
1.37
0.83
8.0
3.4
27.44
231.10
ng/l
1.14
26
200
10
62
1.65
0.66
9.0
3.5
49.35
46.90
%
—
10
62
5
29
1.75
0.64
1.0
1.2
—
—
—
0
0
47
550
0.80
0.62
2.4
2.0
1.30
1.32
mmol/l
0.05
40
464
140
1331
1.29
0.59
31.9
15.1
25.38
23.70
mg/l
0.16
122
1093
6
37
1.64
0.56
2.8
2.4
243.67
192.65
%
—
6
37
65
575
1.21
0.55
6.7
3.9
0.00
0.01
estimate
0.50
15
135
132
1251
1.25
0.54
10.4
5.3
1.79
1.89
mu/l
0.46
124
1135
6
39
1.56
0.53
1.0
1.3
—
—
—
0
0
6
40
1.52
0.52
1.8
2.6
—
—
—
0
0
21
164
1.32
0.49
1.8
2.1
—
—
—
0
0
7
46
1.54
0.49
1.0
1.2
—
—
—
0
0
7
47
1.51
0.48
1.0
1.2
—
—
—
0
0
130
1241
1.20
0.42
8.2
5.9
43.13
39.13
mmol/mol
2.55
119
1161
0
15
0.00
0.41
0.0
1.7
—
821.93
—
0
15
5
36
1.40
0.38
1.0
1.5
—
—
—
0
0
6
42
1.44
0.36
1.2
1.7
—
—
—
0
0
15
188
0.78
0.35
3.9
3.1
0.81
0.94
ug/l
—
10
130
14
111
1.28
0.31
21.2
5.6
1.48
1.34
mmol/l
0.17
14
111
124
1281
0.88
0.26
5.9
5.0
6.18
5.84
mmol/l
1.16
112
1164
119
1230
0.89
0.24
5.0
4.1
1.42
1.22
mmol/l
1.15
109
1118
14
115
1.24
0.24
3.6
2.5
0.49
0.17
e6/l
0.46
14
110
29
257
1.15
0.24
1.3
1.3
1.29
10.63
u/ml
—
8
103
128
1317
0.89
0.23
6.2
5.6
2.44
2.67
mmol/l
2.11
117
1214
5
39
1.29
0.23
1.0
1.2
1.30
1.64
g/l
—
5
39
125
1286
0.89
0.22
5.8
4.9
1.42
1.52
mmol/l
1.46
112
1185
5
42
1.20
0.21
1.0
1.3
0.71
0.86
g/l
—
5
42
5
42
1.20
0.21
2.6
2.0
103.80
94.76
%
—
5
42
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.7
—
9.16
—
0
11
0
12
0.00
0.21
0.0
1.6
—
6.83
—
0
12
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
6
48
1.26
0.20
1.2
1.4
—
—
—
0
0
19
217
0.86
0.20
2.9
3.1
4.60
2.69
e6/l
—
8
113
6
51
1.18
0.19
1.2
1.6
—
—
—
0
0
16
137
1.19
0.19
5.7
3.6
—
—
—
0
0
8
69
1.17
0.16
6.8
2.2
1.04
1.22
%
—
8
69
36
333
1.10
0.16
8.3
4.0
1.01
1.02
kg/l
0.31
24
216
9
79
1.15
0.15
1.0
1.4
—
—
—
0
0
88
849
1.08
0.15
3.6
3.3
—
—
—
0
0
46
433
1.09
0.14
7.0
4.0
0.00
0.00
estimate
-0.00
18
146
30
278
1.10
0.13
1.4
1.3
15.72
28.97
iu/ml
—
6
90
12
104
1.17
0.12
1.3
1.2
146.20
108.99
u/ml
—
5
48
79
763
1.07
0.12
6.5
4.0
0.00
0.00
estimate
-0.00
17
150
127
1291
0.94
0.10
5.8
5.0
4.34
4.63
mmol/l
2.20
115
1200
78
758
1.05
0.09
6.6
4.0
67.00
10.09
estimate
0.39
20
161
22
235
0.93
0.08
3.4
3.0
0.90
0.99
e6/l
0.11
12
129
13
118
1.11
0.07
1.4
1.4
—
—
—
0
0
77
752
1.04
0.07
6.6
4.0
0.00
0.00
estimate
-0.00
19
160
8
93
0.85
0.07
2.8
2.0
—
—
—
0
0
12
110
1.10
0.05
2.3
2.2
—
—
—
0
0
14
149
0.93
0.03
9.5
7.2
—
—
—
0
0
39
400
0.97
0.03
5.7
3.2
0.11
0.33
e6/l
1.81
30
285
24
246
0.97
0.00
5.1
4.5
23.18
21.44
%
0.30
12
135
140
1403
0.99
0.00
16.7
11.6
24.19
24.43
u/l
0.09
134
1362
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
3.7
—
4.60
—
0
6
0
6
0.00
0.00
0.0
1.8
—
47.50
—
0
6
0
6
0.00
0.00
0.0
1.0
—
9.24
—
0
6
0
8
0.00
0.00
0.0
1.8
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
3.7
—
11.57
—
0
6
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
86.36
—
0
5
0
9
0.00
-0.00
0.0
4.3
—
283.89
—
0
9
0
7
0.00
-0.00
0.0
1.0
—
1876.29
—
0
7
7
70
1.00
-0.00
6.7
2.8
22.13
24.41
mmol/l
—
7
70
8
88
0.90
-0.00
37.4
4.9
23.81
24.64
mmol/l
—
8
88
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
90.60
—
0
5
5
50
1.00
-0.00
1.0
1.2
—
11.60
—
0
9
0
7
0.00
-0.00
0.0
1.4
—
10.71
—
0
7
7
79
0.88
-0.00
1.1
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_VIT_A_DEF and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_VIT_A_DEF | 2.193 [1.78, 2.7] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.182 |
During the follow-up period (1.1.1998 — 31.12.2019), 420 out of 942 females with E4_VIT_A_DEF died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_VIT_A_DEF | 2.936 [2.06, 4.18] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 282 out of 450 males with E4_VIT_A_DEF died.
Mortality risk
Mortality risk for people of age
years, who have E4_VIT_A_DEF.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.208% | 0.662% |
| 5 | 1.253% | 3.621% |
| 10 | 2.98% | 7.887% |
| 15 | 5.729% | 14.718% |
| 20 | 10.213% | 23.711% |
Relationships between endpoints
↥Index endpoint: E4_VIT_A_DEF – Vitamin A deficiency
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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