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Drug-induced thyroiditis

DOID Endpoint Browser PheWeb

E4_THYROIDITDRUG

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E06.4#
  • Hospital discharge: ICD-9 — 2454
  • Cause of death: ICD-10 — E06.4#
  • Cause of death: ICD-9 — 2454

2 out of 7 registries used, show all original rules.

100

4. Check minimum number of events

None

100

5. Include endpoints

None

100

6. Filter based on genotype QC (FinnGen only)

89

Control definitions (FinnGen only)

Control exclude
E4_THYROID

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E06
Name in latin
Thyreoiditis ex medicamento

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 273 126 144
Only index persons 239 112 127
Unadjusted period prevalence (%)
Whole population 0.00 0.00 0.00
Only index persons 0.00 0.00 0.00
Median age at first event (years)
Whole population 56.73 52.31 60.48
Only index persons 55.96 50.66 60.63

-FinnGen-

Key figures

All Female Male
Number of individuals 89 43 46
Unadjusted period prevalence (%) 0.02 0.02 0.02
Median age at first event (years) 58.53 57.44 59.55

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
96
Matched controls
960
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
C01BD01
ATC
amiodarone; systemic
301.5
146.5
73
10
E06.4
ICD-10 Finland
Drug-induced thyroiditis
+∞
132.7
94
*
H03BB01
ATC
carbimazole; oral
1361.3
87.0
72
*
TFP20
NOMESCO Finland
Cardiodefibrillation
30.5
61.8
50
33
I48
ICD-10 Finland
Atrial fibrillation and flutter
25.8
58.3
72
100
207
Kela drug reimbursment
Chronic arrhythmias
21.0
53.4
63
80
I48.0
ICD-10 Finland
Paroxysmal atrial fibrillation
17.1
42.5
46
49
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
626.4
41.4
38
*
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
13.6
37.6
50
71
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
13.2
37.6
54
85
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
10.2
30.1
55
112
XF400
NOMESCO Finland
ECG with 12 standard connections
10.7
30.0
46
76
B01AA03
ATC
warfarin; systemic
10.3
29.8
49
88
C03DA01
ATC
spironolactone; oral
10.6
26.9
38
56
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
13.4
26.4
29
30
H03AA01
ATC
levothyroxine sodium; systemic
53.5
25.8
30
8
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
11.0
24.1
31
40
XF404
NOMESCO Finland
Ambulatory ECG
11.1
23.1
29
36
I48.1
ICD-10 Finland
Persistent atrial fibrillation
32.2
21.5
28
12
C07AB07
ATC
bisoprolol; oral
11.8
20.4
84
357
TFP46
NOMESCO Finland
Ablation treatment of atrial fibrillation
44.9
20.0
24
7
K78
ICPC
Atrial fibrillation/flutter
9.8
19.8
27
37
TFP34
NOMESCO Finland
Electrophysiological investigation
33.2
19.4
25
10
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
+∞
19.4
18
*
I50.9
ICD-10 Finland
Heart failure, unspecified
7.9
19.0
33
60
WX404
NOMESCO Finland
Intravenous generell anesthesy
6.4
17.9
43
108
E05.89
ICD-10 Finland
Other thyrotoxicosis
+∞
17.2
16
*
B01AF02
ATC
apixaban; oral
6.6
16.6
35
77
C01AA05
ATC
digoxin; systemic
16.4
15.5
25
20
C03CA01
ATC
furosemide; systemic
5.5
15.5
49
154
C07AA07
ATC
sotalol; systemic
24.0
15.0
21
11
201
Kela drug reimbursment
Chronic cardiac insufficiency
14.9
14.9
25
22
TFC25
NOMESCO Finland
Transseptal catheterisation of left atrium or ventricle
31.1
14.0
18
7
TFP35
NOMESCO Finland
Electroanatomical mapping
31.1
14.0
18
7
I42.0
ICD-10 Finland
Dilated cardiomyopathy
23.3
13.6
19
10
C09AA05
ATC
ramipril; oral
4.9
13.5
47
157
XF402
NOMESCO Finland
ECG with work load test
6.5
13.0
25
49
GD1AA
NOMESCO Finland
Thorax X-ray examination
5.4
12.5
73
356
104
Kela drug reimbursment
Thyroid insufficiency
+∞
11.7
11
*
Z45.0
ICD-10 Finland
Adjustment and management of cardiac devices
21.0
11.2
16
9
TPH04
NOMESCO Finland
Cathetrisation of vein
4.3
10.9
41
141
C01BC04
ATC
flecainide; systemic
12.8
10.9
19
18
Z2221
NOMESCO Finland
Medical doctor
4.2
10.6
43
156
ZXE00
NOMESCO Finland
One hour or less
4.1
10.6
52
216
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
4.5
10.5
34
104
R4110
NOMESCO Finland
Physiotherapy
4.1
10.5
46
176
I50.1
ICD-10 Finland
Left ventricular failure
12.7
10.3
18
17
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
4.7
10.2
30
85
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
5.3
10.1
24
57
K80
ICPC
Cardiac arrhythmia NOS
5.7
9.8
21
45
ZXD10
NOMESCO Finland
Scheduled procedure
3.8
9.7
52
226
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
10.0
9.6
19
23
Z95.0
ICD-10 Finland
Presence of electronic cardiac devices
13.4
9.5
16
14
Z3226
NOMESCO Finland
Physiotherapist
4.4
9.3
29
86
H02AB06
ATC
prednisolone; systemic
3.7
8.6
65
346
I50.0
ICD-10 Finland
Congestive heart failure
7.4
8.1
19
31
WX892
NOMESCO Finland
Monitored bed care
7.4
8.1
19
31
B01AF01
ATC
rivaroxaban; oral
4.3
7.9
24
69
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
49.1
7.9
9
*
I46.0
ICD-10 Finland
Cardiac arrest with successful resuscitation
86.5
7.5
8
*
K04
ICPC
Palpitations/awareness of heart
8.7
7.2
15
20
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
7.8
7.2
16
24
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
3.3
7.2
37
152
Z3231
NOMESCO Finland
Registered nurse
3.2
6.8
40
177
C01BD07
ATC
dronedarone; oral
74.6
6.5
7
*
342
Kela drug reimbursment
Dronedarone
74.6
6.5
7
*
250, ,
Kela drug reimbursment
12.2
6.5
11
10
I47.2
ICD-10 Finland
Ventricular tachycardia
12.2
6.5
11
10
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
3.0
6.4
42
196
AA1AD
NOMESCO Finland
CT of head and brain
3.0
6.4
41
189
A02BC02
ATC
pantoprazole; systemic
4.0
6.4
81
549
I42.9
ICD-10 Finland
Cardiomyopathy, unspecified
28.8
6.3
8
*
XF600
NOMESCO Finland
Bloodpressure measurement
6.4
6.3
16
29
AR6
HP
Catheter ablation of arrhythmia, target: atrial fibrillation
+∞
6.3
6
*
TPH07
NOMESCO Finland
Cathetrisation of artery
4.0
6.3
20
59
WX402
NOMESCO Finland
General anaesthesia
3.1
6.3
36
156
I47.1
ICD-10 Finland
Supraventricular tachycardia
11.1
6.2
11
11

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
42
39
18.37
42.18
1.2
1.2
41.59
44.97
u/ml
—
12
9
41
69
9.63
25.93
18.4
6.3
—
—
—
0
0
49
113
7.81
22.96
15.6
5.0
105.22
103.94
mmol/l
1.31
49
113
31
47
9.26
21.02
4.7
2.8
250.81
122.44
ng/l
1.58
31
41
29
45
8.80
19.16
5.6
2.8
24.08
24.27
mmol/l
0.15
29
45
29
51
7.71
17.05
14.2
6.7
25.22
24.09
mmol/l
0.94
29
51
33
67
6.98
16.94
9.7
8.1
8.80
8.60
mmol/l
0.07
33
61
29
52
7.56
16.73
19.5
7.1
1.29
1.34
%
0.11
29
52
29
52
7.56
16.73
20.8
7.0
0.60
0.67
%
0.45
29
52
63
241
5.70
15.77
6.3
4.1
7.40
7.39
ph
0.32
43
166
26
50
6.76
13.87
21.3
6.5
24.03
24.34
mmol/l
0.18
26
50
42
126
5.15
13.78
3.6
2.7
2.46
2.35
g/l
0.52
42
112
35
90
5.55
13.75
16.5
6.7
7.46
7.42
ph
1.56
11
53
42
135
4.75
12.48
4.1
2.8
13.54
12.88
umol/l
0.21
42
122
34
94
5.05
12.13
16.9
6.4
0.62
0.52
mmol/l
0.05
29
84
78
413
5.74
11.76
48.3
12.4
1.64
1.22
inr
4.77
72
331
25
54
5.91
11.74
5.1
2.3
0.96
1.22
%
0.76
25
54
24
52
5.82
11.20
5.2
2.3
0.48
0.66
%
1.74
24
52
20
21
11.71
10.91
4.9
2.0
61.41
61.78
%
0.02
20
21
20
22
11.16
10.66
4.9
2.5
60.15
60.97
%
0.05
20
22
30
87
4.56
9.90
6.1
3.8
7.38
7.40
ph
0.46
12
51
54
239
3.88
9.87
9.9
6.2
—
—
—
0
0
81
493
5.12
8.94
15.6
10.7
4.21
4.20
e9/l
0.00
67
434
32
109
3.90
8.39
1.7
1.5
—
—
—
0
0
81
518
4.61
7.74
14.0
4.4
6.58
6.57
mmol/l
0.03
81
489
55
282
3.23
7.37
9.2
5.9
—
—
—
0
0
34
133
3.41
7.11
2.7
3.0
1.44
1.91
e6/l
0.16
16
68
12
11
12.26
7.02
2.6
2.2
12.13
10.95
%
0.32
12
11
46
230
2.92
6.18
7.8
4.3
—
—
—
0
0
70
448
3.08
5.80
9.0
6.3
0.61
0.58
e9/l
0.37
60
390
70
449
3.06
5.75
9.0
6.3
0.04
0.04
e9/l
0.33
60
390
71
460
3.09
5.71
9.5
7.0
0.17
0.20
e9/l
1.03
61
412
70
453
3.01
5.59
9.1
6.4
1.78
1.85
e9/l
0.23
60
406
47
251
2.71
5.41
2.7
3.1
0.73
0.31
e6/l
0.37
33
182
20
67
3.51
5.19
4.1
4.1
96.45
78.34
ng/l
0.37
20
60
60
368
2.68
5.15
7.0
4.5
35.53
36.03
g/l
0.30
60
352
49
286
2.46
4.48
3.0
3.2
165.84
64.87
e6/l
0.55
37
216
59
375
2.49
4.47
5.7
2.9
174.49
129.89
ug/l
0.73
59
359
63
416
2.50
4.34
9.7
6.2
8.94
8.76
%
0.14
63
394
28
127
2.70
4.30
2.4
2.0
—
—
—
0
0
22
89
2.91
4.17
1.6
1.6
—
—
—
0
0
58
374
2.39
4.14
13.4
11.9
0.00
0.01
e9/l
0.50
45
301
62
412
2.43
4.13
9.9
6.3
0.59
0.67
%
0.64
62
386
10
18
6.07
4.10
1.3
1.4
—
—
—
0
0
62
413
2.42
4.09
10.0
6.2
2.26
2.84
%
1.85
62
388
7
7
10.66
4.08
1.7
1.4
27.27
19.14
ng/l
—
7
7
51
330
2.16
3.39
4.4
4.0
96.45
41.82
e6/l
0.44
38
227
9
19
5.11
3.33
2.2
4.2
7.40
7.41
ph
—
9
19
44
272
2.14
3.26
6.4
3.3
2.34
2.35
mmol/l
0.38
44
249
6
8
7.90
3.10
1.0
1.4
—
—
—
0
0
6
8
7.90
3.10
1.0
1.3
—
—
—
0
0
72
546
2.27
3.06
4.8
4.3
—
1046.63
—
0
8
52
349
2.07
3.04
8.0
3.5
24.04
37.32
ng/l
0.76
38
261
28
149
2.24
2.97
1.6
1.6
—
—
—
0
0
44
282
2.03
2.88
4.4
2.3
—
—
—
0
0
35
207
2.09
2.84
2.0
1.5
2.41
1.34
mg/l
0.56
29
162
5
6
8.70
2.78
1.4
1.7
—
—
—
0
0
17
74
2.58
2.77
3.6
2.1
68.20
72.93
e9/l
—
9
50
52
359
1.98
2.72
2.6
1.9
98.51
92.79
pmol/l
0.35
36
175
22
110
2.30
2.68
2.0
1.7
—
—
—
0
0
31
180
2.07
2.61
1.5
1.3
19.44
31.60
iu/ml
0.74
11
61
57
410
1.96
2.61
3.9
2.8
—
—
estimate
—
0
0
6
11
5.73
2.58
1.7
1.3
—
—
—
0
0
23
122
2.16
2.43
1.6
1.3
293.33
265.45
titre
—
6
33
8
22
3.87
2.42
1.0
1.3
—
—
—
0
0
5
8
6.52
2.40
1.4
1.0
—
—
—
0
0
5
8
6.52
2.40
2.2
1.0
—
—
—
0
0
6
13
4.84
2.31
1.0
1.2
—
—
—
0
0
22
117
2.14
2.30
1.7
1.5
—
—
—
0
0
10
39
2.74
2.01
4.0
3.0
36.90
36.91
°c
—
10
39
13
59
2.39
1.94
1.5
1.5
—
—
—
0
0
82
702
2.15
1.91
52.8
19.2
13.95
13.63
%
0.87
82
693
5
12
4.33
1.84
1.4
1.4
—
—
—
0
0
91
826
2.95
1.79
7.1
6.4
39.45
39.69
mmol/mol
0.11
91
782
44
327
1.64
1.55
2.2
2.0
—
—
—
0
0
7
27
2.71
1.54
1.4
1.6
1.27
1.17
g/l
—
7
27
7
27
2.71
1.54
1.4
1.6
0.25
0.24
g/l
—
7
27
6
21
2.98
1.53
8.7
3.1
10.78
11.95
mg/l
—
6
21
6
21
2.98
1.53
3.3
3.6
3.85
3.99
mmol/l
—
6
21
41
308
1.58
1.34
6.3
3.3
7.77
8.29
mmol/l
0.43
41
269
18
112
1.75
1.19
1.4
1.4
—
—
—
0
0
7
30
2.44
1.15
1.0
1.1
—
—
—
0
0
8
41
2.04
1.11
1.3
1.2
—
—
—
0
0
23
157
1.61
1.09
1.4
1.4
7.24
5.70
u/ml
—
5
63
39
306
1.46
0.99
4.9
3.5
—
—
—
0
0
0
31
0.00
0.98
0.0
5.8
—
—
—
0
0
9
51
1.84
0.98
1.8
1.9
—
—
—
0
0
6
27
2.30
0.95
1.5
2.3
—
—
—
0
0
17
112
1.63
0.93
1.8
1.2
—
—
—
0
0
17
114
1.60
0.87
1.4
1.2
—
—
—
0
0
6
31
2.00
0.86
1.0
1.3
—
—
—
0
0
6
31
2.00
0.86
2.3
3.3
1.82
1.44
mg/l
—
6
26
6
32
1.93
0.83
1.3
1.0
—
—
—
0
0
6
32
1.93
0.83
2.2
4.3
38.07
45.82
mg/l
—
6
25
6
32
1.93
0.83
2.2
4.3
24.58
24.68
mg/l
—
6
25
31
243
1.41
0.76
1.4
1.4
—
—
—
0
0
36
290
1.39
0.76
4.9
3.4
75.97
48.56
mg/l
0.44
30
200
5
27
1.90
0.69
16.2
1.4
—
—
—
0
0
5
28
1.83
0.67
16.2
1.5
—
—
—
0
0
5
28
1.83
0.67
8.6
3.6
658.00
157.56
mg/l
—
5
9
5
29
1.76
0.64
16.2
1.4
—
—
—
0
0
5
29
1.76
0.64
16.2
1.4
—
—
—
0
0
5
29
1.76
0.64
16.2
1.4
—
—
—
0
0
5
29
1.76
0.64
16.2
1.4
—
—
—
0
0
29
355
0.74
0.64
2.8
3.3
—
—
—
0
0
12
80
1.57
0.63
1.6
1.3
—
—
—
0
0
8
50
1.65
0.63
2.9
4.6
—
—
—
0
0
0
22
0.00
0.60
0.0
1.1
—
—
—
0
0
36
300
1.32
0.59
5.3
4.0
18.00
8.83
mg/mmol
0.64
28
197
6
35
1.76
0.59
7.0
3.3
—
—
—
0
0
6
37
1.66
0.56
1.3
1.6
—
—
—
0
0
45
391
1.28
0.54
5.1
3.4
6.05
6.13
ph
0.20
19
223
28
233
1.28
0.46
3.5
3.1
—
—
—
0
0
8
56
1.47
0.44
8.3
3.1
7.43
7.42
ph
—
8
51
8
57
1.44
0.43
1.8
1.2
—
—
—
0
0
5
32
1.59
0.43
20.2
7.6
—
—
—
0
0
17
212
0.76
0.41
4.5
5.1
—
—
—
0
0
0
18
0.00
0.40
0.0
3.1
—
62.58
—
0
18
12
95
1.30
0.28
1.2
1.5
—
—
—
0
0
51
474
1.16
0.26
4.2
3.8
0.00
0.00
estimate
—
5
92
5
41
1.23
0.22
2.0
2.3
—
—
—
0
0
5
41
1.23
0.22
2.6
1.8
—
—
—
0
0
0
11
0.00
0.21
0.0
2.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
3.0
—
4.65
—
0
11
0
11
0.00
0.21
0.0
2.5
—
552.60
—
0
5
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
2.0
—
—
—
0
0
0
12
0.00
0.21
0.0
2.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
26
236
1.14
0.17
2.9
3.0
0.74
0.72
ug/l
0.04
15
152
9
107
0.82
0.14
1.1
1.3
—
—
—
0
0
23
213
1.10
0.10
5.5
3.5
1.02
1.02
kg/l
0.92
13
136
50
482
1.08
0.09
4.3
3.9
0.00
0.00
estimate
—
5
94
6
55
1.10
0.09
1.0
1.1
—
—
—
0
0
5
64
0.77
0.08
8.2
4.1
—
—
—
0
0
25
265
0.92
0.08
3.7
3.5
0.00
0.00
estimate
—
5
85
8
75
1.07
0.07
1.3
1.2
—
—
—
0
0
18
167
1.10
0.07
1.5
1.7
508.00
79054533.48
pmol/l
0.50
18
148
9
87
1.04
0.07
1.3
1.3
—
—
—
0
0
19
191
0.99
0.00
2.6
1.4
3.18
2.49
g/l
—
10
119
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.2
—
85.20
—
0
5
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
236.50
—
0
8
0
6
0.00
-0.00
0.0
1.0
—
1905.00
—
0
6
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.8
—
53.50
—
0
6
0
7
0.00
-0.00
0.0
1.4
—
1.28
—
0
7
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.8
—
0.45
—
0
6
0
7
0.00
-0.00
0.0
1.0
—
6.51
—
0
7
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
54.17
—
0
6
6
67
0.89
-0.00
16.7
3.8
7.39
7.35
ph
—
6
48
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.8
—
—
—
0
0
7
72
0.97
-0.00
2.4
2.9
2.79
0.12
e6/l
—
7
67
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.0
—
41.01
—
0
7
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint E4_THYROIDITDRUG and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have E4_THYROIDITDRUG.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

↥

Index endpoint: E4_THYROIDITDRUG – Drug-induced thyroiditis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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